CN107718587A - A kind of multifunctional medical conduit and preparation method thereof, application - Google Patents
A kind of multifunctional medical conduit and preparation method thereof, application Download PDFInfo
- Publication number
- CN107718587A CN107718587A CN201710994590.8A CN201710994590A CN107718587A CN 107718587 A CN107718587 A CN 107718587A CN 201710994590 A CN201710994590 A CN 201710994590A CN 107718587 A CN107718587 A CN 107718587A
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- Prior art keywords
- layer
- pvc
- multifunctional medical
- emulsion layer
- conduit
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- MTZQAGJQAFMTAQ-UHFFFAOYSA-N ethyl benzoate Chemical compound CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- RBNPOMFGQQGHHO-UHFFFAOYSA-N glyceric acid Chemical compound OCC(O)C(O)=O RBNPOMFGQQGHHO-UHFFFAOYSA-N 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 235000010985 glycerol esters of wood rosin Nutrition 0.000 description 1
- 235000019443 glyceryl diacetate Nutrition 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000000944 linseed oil Substances 0.000 description 1
- 235000021388 linseed oil Nutrition 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- PRZYKDRCYOLTQA-UHFFFAOYSA-N methyl 2,5,11,14,18-pentachlorooctadecanoate Chemical compound COC(=O)C(Cl)CCC(Cl)CCCCCC(Cl)CCC(Cl)CCCCCl PRZYKDRCYOLTQA-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 description 1
- 229940073769 methyl oleate Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- RZRNAYUHWVFMIP-UHFFFAOYSA-N monoelaidin Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-UHFFFAOYSA-N 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000002969 morbid Effects 0.000 description 1
- WIBFFTLQMKKBLZ-SEYXRHQNSA-N n-butyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCCCC WIBFFTLQMKKBLZ-SEYXRHQNSA-N 0.000 description 1
- DKYVVNLWACXMDW-UHFFFAOYSA-N n-cyclohexyl-4-methylbenzenesulfonamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC1CCCCC1 DKYVVNLWACXMDW-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001596 poly (chlorostyrenes) Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000012959 renal replacement therapy Methods 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000003784 tall oil Substances 0.000 description 1
- 229920001897 terpolymer Polymers 0.000 description 1
- PZTAGFCBNDBBFZ-UHFFFAOYSA-N tert-butyl 2-(hydroxymethyl)piperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCCCC1CO PZTAGFCBNDBBFZ-UHFFFAOYSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N tetrahydrofuran Substances C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- UFDHBDMSHIXOKF-UHFFFAOYSA-N tetrahydrophthalic acid Natural products OC(=O)C1=C(C(O)=O)CCCC1 UFDHBDMSHIXOKF-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- YZWRNSARCRTXDS-UHFFFAOYSA-N tripropionin Chemical compound CCC(=O)OCC(OC(=O)CC)COC(=O)CC YZWRNSARCRTXDS-UHFFFAOYSA-N 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000010148 water-pollination Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C69/00—Combinations of shaping techniques not provided for in a single one of main groups B29C39/00 - B29C67/00, e.g. associations of moulding and joining techniques; Apparatus therefore
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
- B29C41/14—Dipping a core
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
- B29C48/09—Articles with cross-sections having partially or fully enclosed cavities, e.g. pipes or channels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C63/00—Lining or sheathing, i.e. applying preformed layers or sheathings of plastics; Apparatus therefor
- B29C63/18—Lining or sheathing, i.e. applying preformed layers or sheathings of plastics; Apparatus therefor using tubular layers or sheathings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B1/00—Layered products having a general shape other than plane
- B32B1/08—Tubular products
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B25/00—Layered products comprising a layer of natural or synthetic rubber
- B32B25/04—Layered products comprising a layer of natural or synthetic rubber comprising rubber as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B25/08—Layered products comprising a layer of natural or synthetic rubber comprising rubber as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/30—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers
- B32B27/304—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers comprising vinyl halide (co)polymers, e.g. PVC, PVDC, PVF, PVDF
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
- B32B7/04—Interconnection of layers
- B32B7/12—Interconnection of layers using interposed adhesives or interposed materials with bonding properties
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L27/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers
- C08L27/02—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers not modified by chemical after-treatment
- C08L27/04—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers not modified by chemical after-treatment containing chlorine atoms
- C08L27/06—Homopolymers or copolymers of vinyl chloride
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L7/00—Compositions of natural rubber
- C08L7/02—Latex
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2535/00—Medical equipment, e.g. bandage, prostheses, catheter
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/18—Applications used for pipes
Abstract
The present invention relates to medical instruments field, and in particular to multifunctional medical conduit and preparation method thereof, application.Multifunctional medical conduit, the multifunctional medical conduit comprise at least catheter main body；The catheter main body includes the emulsion layer of internal layer medical PVC layer and outer layer；The thickness of the medical PVC layer is 0.1~50mm；The thickness of the emulsion layer is 0.1~50mm.
Description
Technical field
The present invention relates to medical instruments field, and in particular to multifunctional medical conduit and preparation method thereof, application.
Background technology
Medical catheter is to connect the tube chamber product general name inside and outside human body, there is the different materials product such as metal, plastics, rubber.
Be widely used in clinic at present, such as discharge opeing, perfusion, dispensing, blood sampling, transmission blood, pass through sensing element detection biology
Body situation, auxiliary import other medical apparatus etc..The raw material of medical catheter are mainly polyvinyl chloride (PVC), polychlorostyrene second
Alkene paste resin (PVC) is because have the advantages of other materials institute is incomparable, as chemical stability is good, processing technology is simple, raw
The good characteristics such as thing compatibility and be widely used.In addition, the processing of PVC paste resin forming has compared with suspending resin adds
Construction equipment is inexpensive, mould simple cheap, can be made into F-SP, foaming easily, can carry out producing etc. on a small quantity multi items it is excellent
Point, therefore application at present is wider, but its anti-microbial property deficiency, easily trigger infection, add the pain and burden of patient.
Thus, it is also very desirable to by the improvement of structure and technique, to develop a while have a lubricity, hydrophilic
Property, the multifunctional medical conduit of biocidal property, scale-preventing performance.
The content of the invention
In order to solve the above-mentioned technical problem, the first aspect of the invention provides a kind of multifunctional medical conduit, described
Multifunctional medical conduit comprises at least catheter main body；
The catheter main body includes the emulsion layer of internal layer medical PVC layer and outer layer；
The thickness of the medical PVC layer is 0.1~50mm；
The thickness of the emulsion layer is 0.1~50mm.
As a kind of preferable technical scheme of the present invention, the multifunctional medical conduit also includes tack coat, the bonding
Layer is between layer of PVC and emulsion layer；The thickness of the tack coat is 0.01~10mm.
As a kind of preferable technical scheme of the present invention, the material of the medical PVC layer, in parts by weight, comprise at least：
As a kind of preferable technical scheme of the present invention, the polyvinyl chloride resin is dimethyldichlorosilane modified PVC resin.
As a kind of preferable technical scheme of the present invention, the heat stabilizer, in parts by weight, comprise at least
As a kind of preferable technical scheme of the present invention, the material of the tack coat is compound for poly-dopamine-polyethylene glycol
Thing.
As a kind of preferable technical scheme of the present invention, in the poly-dopamine-polyethylene glycol complex, poly-dopamine with
Weight ratio between polyethylene glycol is 1：(1~8).
As a kind of preferable technical scheme of the present invention, the material of the emulsion layer, in parts by weight, including at least following
Component：
100 parts of natural emulsion；
5~20 parts of chitosan.
The second aspect of the invention provides the preparation method of multifunctional medical conduit, including at least following steps,
(1) layer of PVC material is provided, layer of PVC material is put into extruder, extrusion molding, obtains layer of PVC；
(2) emulsion layer material is provided, is first that quality solubility is by the cylindrical stainless steel mould for installing handle immersion concentration
10 seconds in 35%w/w calcium chloride water, lifted with 0.1cm/s speed, be put into 100 DEG C of oven dryings 5 minutes, then inserted
Enter in the emulsion layer material containing vulcanizing agent 10 seconds, then mould is lifted with 0.05cm/s speed, slowly rotate 20 seconds, put
Enter 90 DEG C of oven dryings 3 minutes, taking-up is cooled to room temperature, obtains emulsion layer；
(3) emulsion layer is socketed in the outer surface of layer of PVC.
The third aspect of the invention provides multifunctional medical conduit answering in medicine equipment and medical treatment consumptive materials field
With.
The above-mentioned of the application and other features, aspect and advantage is more readily understood with reference to described further below.
Embodiment
Participate in the election of the detailed description of the invention below for being preferable to carry out method and including embodiment this hair can be more easily understood
Bright content.Unless otherwise defined, all technologies used herein and scientific terminology have common with art of the present invention
The identical implication that technical staff is generally understood that.When contradiction be present, the definition in this specification is defined.
As used herein term " by ... prepare " it is synonymous with "comprising".Term "comprising" used herein, " comprising ",
" having ", " containing " or its any other deformation, it is intended that cover including for non-exclusionism.For example, the combination comprising listed elements
Thing, step, method, product or device are not necessarily limited to those key elements, but can include not expressly listed other key elements or
Such a composition, step, method, product or the intrinsic key element of device.
Conjunction " Consists of " excludes any key element do not pointed out, step or component.If be used in claim, this
Phrase will make claim be closed, it is not included the material in addition to the material of those descriptions, but relative normal
Except rule impurity.When being rather than immediately following in the clause that phrase " Consists of " appears in claim main body after theme,
It is only limited to the key element described in the clause；Other key elements are not excluded outside the claim as entirety.
Equivalent, concentration or other values or parameter are excellent with scope, preferred scope or a series of upper limit preferred values and lower limit
During the Range Representation that choosing value limits, this, which is appreciated that, specifically discloses by any range limit or preferred value and any scope
All scopes that any pairing of lower limit or preferred value is formed, regardless of whether the scope separately discloses.For example, when open
During scope " 1 to 5 ", described scope should be interpreted as including scope " 1 to 4 ", " 1 to 3 ", " 1 to 2 ", " 1 to 2 and 4 to
5 ", " 1 to 3 and 5 " etc..When number range is described herein, unless otherwise indicated, otherwise the scope is intended to include its end
Value and all integers and fraction within the range.
Singulative includes plural number and object is discussed, unless the context clearly dictates otherwise." optional " or it is " any
It is a kind of " refer to that the item that describes thereafter or event may or may not occur, and the description include situation that event occurs and
The situation that event does not occur.
Approximate term in specification and claims is used for modifying quantity, and it is specific to represent that the present invention is not limited to this
Quantity, include the part of the amendment of the acceptable change without cause related basic function close to the quantity.Phase
Answer, modify a numerical value with " about ", " about " etc., mean that the invention is not restricted to the exact numerical.It is approximate in some examples
Term likely corresponds to the precision of the instrument of measured value.In present specification and claims, scope limits can be with
Combine and/or exchange, these scopes include all subranges contained therebetween if not stated otherwise.
In addition, indefinite article " one kind " before key element of the present invention or component and "one" to key element or the quantitative requirement of component
(i.e. occurrence number) unrestriction.Therefore "one" or " one kind " should be read as including one or at least one, and odd number
The key element or component of form also include plural form, unless the obvious purport of the quantity refers to singulative.
" polymer " means by the polymerizable compound prepared by the monomer that polymerize identical or different type.Generic term
" polymer " includes term " homopolymer ", " copolymer ", " terpolymer " and " EVA ".
In order to solve the above-mentioned technical problem, the first aspect of the invention provides a kind of multifunctional medical conduit, described
Multifunctional medical conduit comprises at least catheter main body；
The catheter main body includes the emulsion layer of internal layer medical PVC layer and outer layer；
The thickness of the medical PVC layer is 0.1~50mm；
The thickness of the emulsion layer is 0.1~50mm.
As a kind of preferable technical scheme of the present invention, the multifunctional medical conduit also includes tack coat, the bonding
Layer is between layer of PVC and emulsion layer；The thickness of the tack coat is 0.01~10mm.
In a kind of most preferably embodiment, the thickness of the medical PVC layer is 3mm；
The thickness of the tack coat is 0.05mm；
The thickness of the emulsion layer is 1mm.
In a preferred embodiment, the material of the medical PVC layer, in parts by weight, is comprised at least：
In a preferred embodiment, the plasticizer is selected from：Stearic acid ester plasticizer, the plasticising of laurate esters
Agent, citric acid ester plasticizer, oleic acid ester plasticizer, epoxy analog derivative plasticizer, sulfonic acid plasticizer, polyalcohol
Any one in derivative plasticizer, maleic acid ester plasticizer and fumaric acid esters plasticizer.
As the example of stearic acid ester plasticizer, include but is not limited to：N-butyl stearate, glycerin monostearate,
Stearic acid 2- butoxyethyls, butyl acetoxystearate, monostearate 1,2- propylene glycol esters, (acetoxyl group is hard for glycerine three
Resin acid) ester, distearyl acid diethylene glycol (DEG) ester, methyl pentachlorostearate, stearic acid methoxy ethyl ester.
As the example of laurate ester plasticizer, include but is not limited to：Mono laurate 1,2- propylene glycol esters, mono laurate
Glyceride, mono laurate diethylene glycol (DEG) ester, laurate fourth 2-ethoxyethyl acetate, polyethylene glycol (400) dilaurate.
As the example of citric acid ester plasticizer, include but is not limited to：Triethyl citrate, tri-n-butyl citrate,
The positive fourth fat of ATEC, acetyl tributyl citrate three, ATHC, acetyl tributyl citrate three (2- ethyl hexyls)
Ester, acetyl tributyl citrate three (the just pungent positive last of the ten Heavenly stems) ester.
As the example of oleic acid ester plasticizer, include but is not limited to：Methyl oleate, n propyl oleate, butyl oleate, oil
Sour tetrahydrofuran methyl esters, methoxyethyl oleate, oleic acid 2- fourths 2-ethoxyethyl acetate, glyceryl monooleate, single diglycol oleate.
As the example of epoxy analog derivative plasticizer, include but is not limited to：Epoxidized soybean oil, epoxy Linseed oil, 4,
5- epoxies diisodecyl tetrahydrophthalate, 4,5- epoxies tetrahydrophthalic acid two (2- ethyl hexyls) ester, epoxystearic acid
Butyl ester, epoxystearic acid 2- ethylhexyls, the different monooctyl ester of epoxystearic acid, epoxidized tall oil acid 2- ethylhexyls, epoxidized soybean oil
Sour 2- ethylhexyls, epoxidized methyl acetorieinoleate, epoxy pupal fat acid butyl ester, epoxyfuoic-oleic, epoxidation glycerine three
Acid esters, epoxy chlorinated paraffin, epoxy chloroparaffin, epoxy cotton seed oil, epoxyoleic acid last of the ten Heavenly stems ester, Monoplex S-70, Flexol GPE.
As the example of sulfonic acid plasticizer, include but is not limited to：Benzene sulfonyl butylamine, neighbour, para toluene sulfonamide, N-
Ethyl-neighbour, p-methylphenyl sulphonylamine, N- cyclohexyl-p-methylphenyl sulphonylamine, phenyl alkylsulf.
As the example of polyol derivative plasticizer, include but is not limited to：Diethylene glycol dibenzoate, triethylene glycol hexichol
Formic acid esters, triethylene glycol two (2 Ethylbutanoic acid) ester, triethylene glycol two (2 ethyl hexanoic acid) ester, triethylene glycol dieaprylate, triethylene glycol two
(C7-9 carboxylates), tetraethylene glycol two (2 ethyl hexanoic acid) ester, diethylene glycol dipelargonate, triethylene glycol dipelargonate, the triethylene glycol pungent last of the ten Heavenly stems
Acid esters, triethylene glycol diheptylate, tetraethylene glycol diheptanoate, ethylene diacetate, triethylene glycol diacetate, 59 acid glycerides,
C5~C9 fatty acid mixeds glycol ester, polyethylene glycol, polyethylene glycol (200) dibenzoate, polyethylene glycol (600) hexichol first
Acid esters, diglycol benzoate and dipropylene glycol benzoate mixture (1:1), neopentyl glycol dibenzoate, triphen
It is formic acid glyceride, dipropylene glycol dibenzoate, propylene glycol dibenzoate, trimethylolethane trimethacrylate benzoic ether, sweet
Oily monoacetate, glyceryl diacetate, triacetin, glycerin tributyrate, glycerol ether acetate, glycerin tripropionate,
Pentaerythritol fatty ester, pentaerythritol tetrabenzoate, the caprylatecaprate of pentaerythrite four, (C5~C9 is mixed pentaerythrite four
Close fatty acid ester), bipentaerythrite support adipic acid six (C5~C9 mixed aliphatic esters).
As the example of maleic acid ester plasticizer, include but is not limited to：N-butyl maleate, (the 2- second of maleic acid two
Base oneself) ester, dimethyl maleate, diethyl maleate.
As the example of fumaric acid esters plasticizer, include but is not limited to：Di n butyl fumarate, (the 2- second of fumaric acid two
Base oneself) ester, diisooctyl fumarate.
In a preferred embodiment, the lubricant is selected from：Tissuemat E.
In a kind of embodiment being more highly preferred to, the polyvinyl chloride resin is dimethyldichlorosilane modified PVC resin.
In the dimethyldichlorosilane modified PVC resin, the weight ratio between dimethyldichlorosilane and polyvinyl chloride resin is
(1~10)：100.
In a preferred embodiment, the preparation method of the dimethyldichlorosilane modified PVC resin include with
Lower step：
(1) using the sodium-chloride water solution that mass concentration is 30% as circulation fluid, by the sodium hydroxide that concentration is 18% (wt)
The aqueous solution and dimethyldichlorosilane are injected in circulation fluid in the ratio that equivalent proportion is 1.05: 1.0, and sodium hydrate aqueous solution is with following
The volume ratio of ring liquid is 1.0: 50, wherein, hydrolysis temperature is 30 DEG C, and hydrolysis time is 60 seconds, obtains dimethyldihydroxysilane；
(2) at room temperature, 2000L, which reacts, adds methylene chloride 1200L in glass reaction bottle, then add into system
Enter 300g polyvinyl chloride resin particles, 10g catalyst imidazoles is added after stirring and dissolving, under nitrogen protection, ice-water bath is cooled to 2
DEG C, the dimethyldihydroxysilane obtained in 30g steps (1) is slowly added to, is finished, warm 20 DEG C of insulation reactions 1.5 are small in control
When, reacting, be washed to neutrality, added running water 400ml, normal pressure is concentrated into solvent-free smell, is cooled to less than 40 DEG C, filters,
Washing, is drained, and is dried, is obtained dimethyldichlorosilane modified PVC resin.
In a preferred embodiment, the heat stabilizer, in parts by weight, comprise at least
In a preferred embodiment, the preparation method of the heat stabilizer is as follows：
By the Zn-PPA of corresponding parts by weight, triphenyl phosphite, pentaerythrite and dibenzoyl methane, using at a high speed
(1500rpm) mixes 20min to mixer at a high speed, obtains heat stabilizer mixture.
The Zn-PPA is Zn-PPA ointment, is purchased from Shanghai Huazhong Pharmaceutical Co., Ltd..
In a preferred embodiment, the preparation method of the material of the medical PVC layer, including at least following step
Suddenly：
Corresponding weight parts PVC resin, plasticizer, lubricant and heat stabilizer are accurately weighed, is put into high-speed mixer,
Rotating speed is adjusted to 1200rpm, stirs 30min, and material then is put into cooling mixing machine again, controls rotating speed 20rpm, treats temperature of charge
To 40~50 DEG C of dischargings；Material through cooling is added into double-screw extruding pelletizing machine, the area's temperature of machine barrel four is respectively：I area 100~
130 DEG C, II 110~140 DEG C of area, III 120~150 DEG C of area, IV 130~160 DEG C of area, die head temperature is 140~160 DEG C, screw rod
60~100rpm of rotating speed；After the extruded plasticizing of material is cooled to 35~45 DEG C after being granulated, packed for standby use.
In a preferred embodiment, the material of the tack coat is poly-dopamine-polyethylene glycol complex.
In the poly-dopamine-polyethylene glycol complex, the weight ratio between poly-dopamine and polyethylene glycol is 1：(1~
8)；Most preferably 1：5.
In a preferred embodiment, the preparation method of the poly-dopamine-polyethylene glycol complex is：
(1) 50ml weight/mass percentage compositions are added in the ethanol water that 500ml concentration of volume percent is 60% is
25% ammoniacal liquor, 30min is stirred, obtains ethanol-ammoniacal liquor mixed solution；
(2) into ethanol-ammoniacal liquor mixed solution of step (1), the dopamine solution that 50ml concentration is 40mg/mL is added,
1000mg polyethylene glycol is added when brown is presented in mixed solution, reacts 15h at room temperature；Obtained product process is washed,
Centrifugation, obtain poly-dopamine and polyethylene glycol after drying.
In a preferred embodiment, the material of the emulsion layer, in parts by weight, including at least following components：
100 parts of natural emulsion；
5~20 parts of chitosan.
In a preferred embodiment, the preparation method of the material of the emulsion layer is：
Natural emulsion is placed in homogenizer, is heated to 200 DEG C, after stirring, is then adding chitosan
Stirring 1 hour, taking-up are as cold as normal temperature by force, then barreled.
The second aspect of the invention provides the preparation method of multifunctional medical conduit, including at least following steps,
(1) layer of PVC material is provided, layer of PVC material is put into extruder, extrusion molding, obtains layer of PVC；
(2) emulsion layer material is provided, is first that quality solubility is by the cylindrical stainless steel mould for installing handle immersion concentration
10 seconds in 35%w/w calcium chloride water, lifted with 0.1cm/s speed, be put into 100 DEG C of oven dryings 5 minutes, then inserted
Enter in the emulsion layer material containing vulcanizing agent 10 seconds, then mould is lifted with 0.05cm/s speed, slowly rotate 20 seconds, put
Enter 90 DEG C of oven dryings 3 minutes, taking-up is cooled to room temperature, obtains emulsion layer；
(3) emulsion layer is socketed in the outer surface of layer of PVC.
In a preferred embodiment, the preparation method of the multifunctional medical conduit, including at least following steps,
(1) layer of PVC material is provided, layer of PVC material is put into extruder, extrusion molding, obtains layer of PVC；
(2) tack coat material is provided, the tack coat outer surface uniform in material for being coated on layer of PVC is contained after drying
The layer of PVC of tack coat；
(3) emulsion layer material is provided, is first that quality solubility is by the cylindrical stainless steel mould for installing handle immersion concentration
10 seconds in 35%w/w calcium chloride water, lifted with 0.1cm/s speed, be put into 100 DEG C of oven dryings 5 minutes, then inserted
Enter in the emulsion layer material containing vulcanizing agent 10 seconds, then mould is lifted with 0.05cm/s speed, slowly rotate 20 seconds, put
Enter 90 DEG C of oven dryings 3 minutes, taking-up is cooled to room temperature, obtains emulsion layer；
(4) emulsion layer is socketed in the outer surface of the layer of PVC containing tack coat.
The third aspect of the invention provides multifunctional medical conduit answering in medicine equipment and medical treatment consumptive materials field
With.
In the application, before multifunctional medical conduit has extraordinary application in medicine equipment and medical treatment consumptive materials field
Scape.
The medicine equipment that can be enumerated in the application has：Hemostasis, scalpel, operating scissors etc..
The medical treatment consumptive materials that can be enumerated have：Venous transfusion consumptive material, blood purification consumptive material, orthopaedics consumptive material, anaesthetize consumptive material, shield wound
Dressing consumptive material, intramuscular injection consumptive material, Interventional consumptive material, amenities of performing the operation, first-aid kit, first-aid dressing, other medical supplies etc..Tool
The usual products of body have CVC, remaining needle, cock, infusion connector, extension tube, dialyzer, dialyzate, perfusion device,
Syringe, transfusion device, absorbent cotton, bandage, medical clothes, medical gloves, mouth mask, first-aid kit (bag) etc..
Wherein, venous transfusion consumptive material, refer to inject liquid, medicine, nutritional support and treatment of blood transfusion by intravenous route, be
The high and professional medical supplies for requiring strong treatment method of one technical requirements.Early stage is only used for critical patient, and nowadays vein is defeated
Liquid has turned into the important means of clinical treatment and nutritional support, or even expands to family, care institutions vibrations, Doctor's office and community doctor
Institute etc..
Venous transfusion consumptive material includes CVC, remaining needle, scalp acupuncture, cock, extension tube, infusion connector, transfusion
Device, syringe etc..
Blood purification consumptive material, blood purification remove it i.e. outside the blood lead body of patient and by particular purification device
In some morbid substances, purify blood, reach treatment disease purpose, this process is blood purification.Blood purification should wrap
Include：Haemodialysis (HD), blood filtering, blood perfusion, plasma exchange, Protein A immunoadsorption, continuous renal replacementtherapy
Deng.
Blood purification consumptive material includes hemodialysis catheter, internal-fistula needle, blood circuit, dialyzer, dialyzate, perfusion device, egg
White absorption, CRRT etc..
The oral or nasal insertion such as gastric canal, feeding tube, tube feed pipe or the conduit class being retained in digestive organs.
Oxygen conduit, oxygen supply intubation, the pipe of endotracheal tube or cuff, the pipe of tracheostomy tube or cuff, tracheal strips extract
The oral or nasal insertion such as conduit is retained in air flue or endotracheal conduit class.
Insertion or the indwellings such as urethral catheter, urethral catheterization conduit, urethra foley's tube, prostate dilator, sacculus or water pocket
Conduit class in urethra or urinary catheter.
Extract conduit, draining pipe, the insertion such as rectal catheter out or be retained in various body cavitys, internal organs, the conduit class in tissue.
Remaining needle, IVH conduits, thermodilution catheter, angiogram conduit, blood vessel dilatation conduit and expander or intubation
Device (introducer) etc. inserts or is retained in the seal wire of endovascular conduit class or these conduits, stylet (stylet)
Deng.
Artificial trachea, artificial bronchus etc..
External circulating therapy medical instruments (artificial lung, artificial heart, artificial kidney etc.), its loop class.
The present invention is specifically described below by embodiment.It is necessarily pointed out that following examples are only used
In the invention will be further described, it is impossible to be interpreted as limiting the scope of the invention, professional and technical personnel in the field
Some the nonessential modifications and adaptations made according to the content of the invention described above, still fall within protection scope of the present invention.
In addition, if without other explanations, it is raw materials used be all it is commercially available, be purchased from traditional Chinese medicines chemical reagent.
Embodiment 1：
Embodiments of the invention 1 provide a kind of multifunctional medical conduit, and the multifunctional medical conduit is comprised at least and led
Pipe main body；
The catheter main body includes the emulsion layer of internal layer medical PVC layer and outer layer；
The thickness of the medical PVC layer is 0.1mm；
The thickness of the emulsion layer is 0.1mm.
The material of the medical PVC layer, in parts by weight, is comprised at least：
The plasticizer is n-butyl stearate；
The lubricant is Tissuemat E, and the Tissuemat E is purchased from Yangzhou rowland new material Co., Ltd；
The heat stabilizer is in parts by weight, to comprise at least
The preparation method of the heat stabilizer is as follows：
By the Zn-PPA of corresponding parts by weight, triphenyl phosphite, pentaerythrite and dibenzoyl methane, using at a high speed
(1500rpm) mixes 20min to mixer at a high speed, obtains heat stabilizer mixture.
The preparation method of the material of the medical PVC layer, including at least following steps：
Corresponding weight parts PVC resin, plasticizer, lubricant and heat stabilizer are accurately weighed, is put into high-speed mixer,
Rotating speed is adjusted to 1200rpm, stirs 30min, and material then is put into cooling mixing machine again, controls rotating speed 20rpm, treats temperature of charge
To 50 DEG C of dischargings；Material through cooling is added into double-screw extruding pelletizing machine, the area's temperature of machine barrel four is respectively：I 130 DEG C of area, II
120 DEG C of area, III 130 DEG C of area, IV 150 DEG C of area, die head temperature are 160 DEG C, screw speed 100rpm；The extruded plasticizing of material is granulated
After be cooled to 40 DEG C after, packed for standby use.
The material of the emulsion layer, in parts by weight, including at least following components：
100 parts of natural emulsion；
5 parts of chitosan.
In a preferred embodiment, the preparation method of the material of the emulsion layer is：
Natural emulsion is placed in homogenizer, is heated to 200 DEG C, after stirring, is then adding chitosan
Stirring 1 hour, taking-up are as cold as normal temperature by force, then barreled.The chitosan is purchased from the limited public affairs of Jinan Hai get Bei marine biotechnologies
Department.
The preparation method of the multifunctional medical conduit, including at least following steps,
(1) layer of PVC material is provided, layer of PVC material is put into extruder, extrusion molding, obtains layer of PVC；
(2) emulsion layer material is provided, is first that quality solubility is by the cylindrical stainless steel mould for installing handle immersion concentration
10 seconds in 35%w/w calcium chloride water, lifted with 0.1cm/s speed, be put into 100 DEG C of oven dryings 5 minutes, then inserted
Enter in the emulsion layer material containing vulcanizing agent 10 seconds, then mould is lifted with 0.05cm/s speed, slowly rotate 20 seconds, put
Enter 90 DEG C of oven dryings 3 minutes, taking-up is cooled to room temperature, obtains emulsion layer；
(3) emulsion layer is socketed in the outer surface of layer of PVC.
Embodiment 2：
Embodiments of the invention 2 provide a kind of multifunctional medical conduit, and the multifunctional medical conduit is comprised at least and led
Pipe main body；
The catheter main body includes the emulsion layer of internal layer medical PVC layer and outer layer；
The thickness of the medical PVC layer is 50mm；
The thickness of the emulsion layer is 50mm.
The material of the medical PVC layer, in parts by weight, is comprised at least：
The plasticizer is n-butyl stearate；
The lubricant is Tissuemat E, and the Tissuemat E is purchased from Yangzhou rowland new material Co., Ltd；
The heat stabilizer is in parts by weight, to comprise at least
The preparation method of the heat stabilizer is as follows：
By the Zn-PPA of corresponding parts by weight, triphenyl phosphite, pentaerythrite and dibenzoyl methane, using at a high speed
(1500rpm) mixes 20min to mixer at a high speed, obtains heat stabilizer mixture.
The preparation method of the material of the medical PVC layer, including at least following steps：
Corresponding weight parts PVC resin, plasticizer, lubricant and heat stabilizer are accurately weighed, is put into high-speed mixer,
Rotating speed is adjusted to 1200rpm, stirs 30min, and material then is put into cooling mixing machine again, controls rotating speed 20rpm, treats temperature of charge
To 50 DEG C of dischargings；Material through cooling is added into double-screw extruding pelletizing machine, the area's temperature of machine barrel four is respectively：I 130 DEG C of area, II
120 DEG C of area, III 130 DEG C of area, IV 150 DEG C of area, die head temperature are 160 DEG C, screw speed 100rpm；The extruded plasticizing of material is granulated
After be cooled to 40 DEG C after, packed for standby use.
The material of the emulsion layer, in parts by weight, including at least following components：
100 parts of natural emulsion；
20 parts of chitosan.
In a preferred embodiment, the preparation method of the material of the emulsion layer is：
Natural emulsion is placed in homogenizer, is heated to 200 DEG C, after stirring, is then adding chitosan
Stirring 1 hour, taking-up are as cold as normal temperature by force, then barreled.The chitosan is purchased from the limited public affairs of Jinan Hai get Bei marine biotechnologies
Department.
The preparation method of the multifunctional medical conduit, including at least following steps,
(1) layer of PVC material is provided, layer of PVC material is put into extruder, extrusion molding, obtains layer of PVC；
(2) emulsion layer material is provided, is first that quality solubility is by the cylindrical stainless steel mould for installing handle immersion concentration
10 seconds in 35%w/w calcium chloride water, lifted with 0.1cm/s speed, be put into 100 DEG C of oven dryings 5 minutes, then inserted
Enter in the emulsion layer material containing vulcanizing agent 10 seconds, then mould is lifted with 0.05cm/s speed, slowly rotate 20 seconds, put
Enter 90 DEG C of oven dryings 3 minutes, taking-up is cooled to room temperature, obtains emulsion layer；
(3) emulsion layer is socketed in the outer surface of layer of PVC.
Embodiment 3：
Embodiments of the invention 3 provide a kind of multifunctional medical conduit, and the multifunctional medical conduit is comprised at least and led
Pipe main body；
The catheter main body includes the emulsion layer of internal layer medical PVC layer, tack coat and outer layer；
The thickness of the medical PVC layer is 3mm；
The thickness of the tack coat is 0.05mm；
The thickness of the emulsion layer is 1mm.
The material of the medical PVC layer, in parts by weight, is comprised at least：
The plasticizer is n-butyl stearate；
The lubricant is Tissuemat E, and the Tissuemat E is purchased from Yangzhou rowland new material Co., Ltd；
The heat stabilizer is in parts by weight, to comprise at least
The preparation method of the heat stabilizer is as follows：
By the Zn-PPA of corresponding parts by weight, triphenyl phosphite, pentaerythrite and dibenzoyl methane, using at a high speed
(1500rpm) mixes 20min to mixer at a high speed, obtains heat stabilizer mixture.
The preparation method of the material of the medical PVC layer, including at least following steps：
Corresponding weight parts PVC resin, plasticizer, lubricant and heat stabilizer are accurately weighed, is put into high-speed mixer,
Rotating speed is adjusted to 1200rpm, stirs 30min, and material then is put into cooling mixing machine again, controls rotating speed 20rpm, treats temperature of charge
To 50 DEG C of dischargings；Material through cooling is added into double-screw extruding pelletizing machine, the area's temperature of machine barrel four is respectively：I 130 DEG C of area, II
120 DEG C of area, III 130 DEG C of area, IV 150 DEG C of area, die head temperature are 160 DEG C, screw speed 100rpm；The extruded plasticizing of material is granulated
After be cooled to 40 DEG C after, packed for standby use.
The material of the tack coat is poly-dopamine-polyethylene glycol complex.
The preparation method of the poly-dopamine-polyethylene glycol complex is：
(1) 50ml weight/mass percentage compositions are added in the ethanol water that 500ml concentration of volume percent is 60% is
25% ammoniacal liquor, 30min is stirred, obtains ethanol-ammoniacal liquor mixed solution；
(2) into ethanol-ammoniacal liquor mixed solution of step (1), the dopamine solution that 50ml concentration is 40mg/mL is added,
1000mg polyethylene glycol is added when brown is presented in mixed solution, reacts 15h at room temperature；Obtained product process is washed,
Centrifugation, obtain poly-dopamine and polyethylene glycol after drying.
The polyethylene glycol is polyethylene glycol 400.
The material of the emulsion layer, in parts by weight, including at least following components：
100 parts of natural emulsion；
10 parts of chitosan.
In a preferred embodiment, the preparation method of the material of the emulsion layer is：
Natural emulsion is placed in homogenizer, is heated to 200 DEG C, after stirring, is then adding chitosan
Stirring 1 hour, taking-up are as cold as normal temperature by force, then barreled.The chitosan is purchased from the limited public affairs of Jinan Hai get Bei marine biotechnologies
Department.
The preparation method of the multifunctional medical conduit, including at least following steps,
(1) layer of PVC material is provided, layer of PVC material is put into extruder, extrusion molding, obtains layer of PVC；
(2) emulsion layer material is provided, is first that quality solubility is by the cylindrical stainless steel mould for installing handle immersion concentration
10 seconds in 35%w/w calcium chloride water, lifted with 0.1cm/s speed, be put into 100 DEG C of oven dryings 5 minutes, then inserted
Enter in the emulsion layer material containing vulcanizing agent 10 seconds, then mould is lifted with 0.05cm/s speed, slowly rotate 20 seconds, put
Enter 90 DEG C of oven dryings 3 minutes, taking-up is cooled to room temperature, obtains emulsion layer；
(3) emulsion layer is socketed in the outer surface of layer of PVC.
Embodiment 4：
Embodiments of the invention 4 provide a kind of multifunctional medical conduit, and the multifunctional medical conduit is comprised at least and led
Pipe main body；
The catheter main body includes the emulsion layer of internal layer medical PVC layer, tack coat and outer layer；
The thickness of the medical PVC layer is 3mm；
The thickness of the tack coat is 0.05mm；
The thickness of the emulsion layer is 1mm.
The material of the medical PVC layer, in parts by weight, is comprised at least：
The plasticizer is n-butyl stearate；
The lubricant is Tissuemat E, and the Tissuemat E is purchased from Yangzhou rowland new material Co., Ltd；
The heat stabilizer is in parts by weight, to comprise at least
The preparation method of the heat stabilizer is as follows：
By the Zn-PPA of corresponding parts by weight, triphenyl phosphite, pentaerythrite and dibenzoyl methane, using at a high speed
(1500rpm) mixes 20min to mixer at a high speed, obtains heat stabilizer mixture.
The polyvinyl chloride resin is dimethyldichlorosilane modified PVC resin；
The preparation method of the dimethyldichlorosilane modified PVC resin comprises the following steps：
(1) using the sodium-chloride water solution that mass concentration is 30% as circulation fluid, by the sodium hydroxide that concentration is 18% (wt)
The aqueous solution and dimethyldichlorosilane are injected in circulation fluid in the ratio that equivalent proportion is 1.05: 1.0, and sodium hydrate aqueous solution is with following
The volume ratio of ring liquid is 1.0: 50, wherein, hydrolysis temperature is 30 DEG C, and hydrolysis time is 60 seconds, obtains dimethyldihydroxysilane；
(2) at room temperature, 2000L, which reacts, adds methylene chloride 1200L in glass reaction bottle, then add into system
Enter 300g polyvinyl chloride resin particles, 10g catalyst imidazoles is added after stirring and dissolving, under nitrogen protection, ice-water bath is cooled to 2
DEG C, the dimethyldihydroxysilane obtained in 30g steps (1) is slowly added to, is finished, warm 20 DEG C of insulation reactions 1.5 are small in control
When, reacting, be washed to neutrality, added running water 400ml, normal pressure is concentrated into solvent-free smell, is cooled to less than 40 DEG C, filters,
Washing, is drained, and is dried, is obtained dimethyldichlorosilane modified PVC resin.
The preparation method of the material of the medical PVC layer, including at least following steps：
Corresponding weight parts PVC resin, plasticizer, lubricant and heat stabilizer are accurately weighed, is put into high-speed mixer,
Rotating speed is adjusted to 1200rpm, stirs 30min, and material then is put into cooling mixing machine again, controls rotating speed 20rpm, treats temperature of charge
To 50 DEG C of dischargings；Material through cooling is added into double-screw extruding pelletizing machine, the area's temperature of machine barrel four is respectively：I 130 DEG C of area, II
120 DEG C of area, III 130 DEG C of area, IV 150 DEG C of area, die head temperature are 160 DEG C, screw speed 100rpm；The extruded plasticizing of material is granulated
After be cooled to 40 DEG C after, packed for standby use.
The material of the tack coat is poly-dopamine-polyethylene glycol complex.
The preparation method of the poly-dopamine-polyethylene glycol complex is：
(1) 50ml weight/mass percentage compositions are added in the ethanol water that 500ml concentration of volume percent is 60% is
25% ammoniacal liquor, 30min is stirred, obtains ethanol-ammoniacal liquor mixed solution；
(2) into ethanol-ammoniacal liquor mixed solution of step (1), the dopamine solution that 50ml concentration is 40mg/mL is added,
1000mg polyethylene glycol is added when brown is presented in mixed solution, reacts 15h at room temperature；Obtained product process is washed,
Centrifugation, obtain poly-dopamine and polyethylene glycol after drying.
The polyethylene glycol is polyethylene glycol 400.
The material of the emulsion layer, in parts by weight, including at least following components：
100 parts of natural emulsion；
10 parts of chitosan.
In a preferred embodiment, the preparation method of the material of the emulsion layer is：
Natural emulsion is placed in homogenizer, is heated to 200 DEG C, after stirring, is then adding chitosan
Stirring 1 hour, taking-up are as cold as normal temperature by force, then barreled.The chitosan is purchased from the limited public affairs of Jinan Hai get Bei marine biotechnologies
Department.
The preparation method of the multifunctional medical conduit, including at least following steps,
(1) layer of PVC material is provided, layer of PVC material is put into extruder, extrusion molding, obtains layer of PVC；
(2) emulsion layer material is provided, is first that quality solubility is by the cylindrical stainless steel mould for installing handle immersion concentration
10 seconds in 35%w/w calcium chloride water, lifted with 0.1cm/s speed, be put into 100 DEG C of oven dryings 5 minutes, then inserted
Enter in the emulsion layer material containing vulcanizing agent 10 seconds, then mould is lifted with 0.05cm/s speed, slowly rotate 20 seconds, put
Enter 90 DEG C of oven dryings 3 minutes, taking-up is cooled to room temperature, obtains emulsion layer；
(3) emulsion layer is socketed in the outer surface of layer of PVC.
Comparative example 1：
The comparative example 1 of the application is with embodiment 1, and difference is, not the emulsion layer including outer layer.
Comparative example 2：
The comparative example 2 of the application is with embodiment 1, and difference is, not including internal layer medical PVC layer.
Comparative example 3：
The comparative example 3 of the application is with embodiment 1, and difference is, the heat stabilizer does not include Zn-PPA.
Comparative example 4：
The comparative example 4 of the application is with embodiment 1, and difference is, the heat stabilizer is calcium zinc stabilizer.
Comparative example 5：
The comparative example 5 of the application is with embodiment 1, and difference is, the emulsion layer does not include chitosan.
Comparative example 6：
The comparative example 6 of the application is with embodiment 2, and difference is, the tack coat is poly-dopamine.
Comparative example 7：
The comparative example 7 of the application is with embodiment 2, and difference is, the tack coat is polyethylene glycol 400.
Comparative example 8：
With embodiment 2, difference is the comparative example 8 of the application, and the tack coat is polyurethane adhesive, the poly- ammonia
Ester gum stick is purchased from 3M.
Comparative example 9：
With embodiment 3, difference is the comparative example 9 of the application, is by dimethyldichlorosilane modified PVC resin replacement
The mixing of dimethyldichlorosilane and polyvinyl chloride resin.
Performance test
1st, catheter stability：The medical catheter that will be obtained in embodiment and comparative example, with body temperature relatively 37
DEG C, pH be 8 water in, soak 48h, after taking-up, see whether emulsion layer can be extracted from layer of PVC with 20N power, if
It can extract, then be designated as 0 grade, it is impossible to extract, be then designated as 1 grade.
2nd, inner and outer wall anti-scaling property：The medical catheter that will be obtained in embodiment and comparative example, is placed in artificial urine
In soaked, soak time be 30 days, whether the inner and outer wall for observing medical catheter has dirt, any dirt occurs and is then
0 grade, no dirt, then it is designated as 1 grade.The artificial urine is purchased from Dongguan City Ke Hong Chemical Co., Ltd.s.
3rd, lubricity：Sample is placed on the other end for the horizontal plane for being fixed with fixed pulley, puller system determines cunning by being wound on
The slightly flexible fine rule of wheel makes sliding block be slided in specimen surface level, and the pulling force shown by puller system is just frictional force F.It is dynamic to rub
Wiping coefficient f is：F=F/W (W：The gravity of sliding block), the quality of sliding block is 200g, sliding speed 100mm/min, puller system essence
Spend for 0.001N.Coefficient of kinetic friction f numerical value is smaller, and greasy property is better.Meanwhile connect using the promise contact angle instrument test of section of the U.S.
Feeler.
4th, bacteriostasis property is tested：Escherichia coli bacteriostasis rate is tested using QB/T4371-2012 methods.
The performance characterization of table 1 is tested
As can be seen from Table 1, the present invention in multifunctional medical conduit have extraordinary stability, scale-preventing performance with
And greasy property, hydrophily, bacteriostasis property.Meanwhile the conduit in the present invention has good flexibility, have with human body preferable
Compatibility.In use, there is not the sensation of any pain.
Foregoing example is merely illustrative, for explaining some features of the method for the invention.Appended right will
Ask and be intended to require the scope as wide as possible being contemplated that, and embodiments as presented herein is only according to all possible implementation
The explanation of the embodiment of the selection of the combination of example.Therefore, the purpose of applicant is that appended claim is not illustrated this hair
The selectional restriction of the example of bright feature.Some number ranges used also include sub- model within the claims
Enclose, the change in these scopes should be also construed to by appended claim covering in the conceived case.
Claims (10)
1. a kind of multifunctional medical conduit, it is characterised in that the multifunctional medical conduit comprises at least catheter main body；
The catheter main body includes the emulsion layer of internal layer medical PVC layer and outer layer；
The thickness of the medical PVC layer is 0.1~50mm；
The thickness of the emulsion layer is 0.1~50mm.
2. multifunctional medical conduit as claimed in claim 1, it is characterised in that the multifunctional medical conduit also includes bonding
Layer, the tack coat is between layer of PVC and emulsion layer；The thickness of the tack coat is 0.01~10mm.
3. multifunctional medical conduit as claimed in claim 1 or 2, it is characterised in that the material of the medical PVC layer, with weight
Part meter is measured, is comprised at least：
4. multifunctional medical conduit as claimed in claim 3, it is characterised in that the polyvinyl chloride resin is dimethyldichlorosilane
Modified PVC resin.
5. multifunctional medical conduit as claimed in claim 3, it is characterised in that the heat stabilizer, in parts by weight, at least
Including
6. multifunctional medical conduit as claimed in claim 1, it is characterised in that the material of the tack coat be poly-dopamine-
Polyethylene glycol complex.
7. multifunctional medical conduit as claimed in claim 6, it is characterised in that the poly-dopamine-polyethylene glycol complex
In, the weight ratio between poly-dopamine and polyethylene glycol is 1：(1~8).
8. multifunctional medical conduit as claimed in claim 1, it is characterised in that the material of the emulsion layer, in parts by weight,
Including at least following components：
100 parts of natural emulsion；
5~20 parts of chitosan.
9. the preparation method of the multifunctional medical conduit described in claim 1, it is characterised in that including at least following steps,
(1) layer of PVC material is provided, layer of PVC material is put into extruder, extrusion molding, obtains layer of PVC；
(2) emulsion layer material is provided, is first that quality solubility is 35% by the cylindrical stainless steel mould for installing handle immersion concentration
10 seconds in w/w calcium chloride water, lifted with 0.1cm/s speed, be put into 100 DEG C of oven dryings 5 minutes, be inserted into and contain
Have in the emulsion layer material of vulcanizing agent 10 seconds, then mould is lifted with 0.05cm/s speed, slowly rotate 20 seconds, be put into 90
DEG C oven drying 3 minutes, taking-up are cooled to room temperature, obtain emulsion layer；
(3) emulsion layer is socketed in the outer surface of layer of PVC.
10. application of the multifunctional medical conduit in medicine equipment and medical treatment consumptive materials field described in claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710994590.8A CN107718587B (en) | 2017-10-23 | 2017-10-23 | A kind of multifunctional medical conduit and preparation method thereof, application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710994590.8A CN107718587B (en) | 2017-10-23 | 2017-10-23 | A kind of multifunctional medical conduit and preparation method thereof, application |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108992714A (en) * | 2018-08-15 | 2018-12-14 | 费宇奇 | A kind of preparation method of hydrophilic medical conduit |
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