CN1077129A - Oral liquid for treatment of esophagus disease and manufacture method thereof - Google Patents
Oral liquid for treatment of esophagus disease and manufacture method thereof Download PDFInfo
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- CN1077129A CN1077129A CN 93103912 CN93103912A CN1077129A CN 1077129 A CN1077129 A CN 1077129A CN 93103912 CN93103912 CN 93103912 CN 93103912 A CN93103912 A CN 93103912A CN 1077129 A CN1077129 A CN 1077129A
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Abstract
The present invention relates to cure mainly the oral liquid for treatment of esophagus disease of esophageal carcinoma, laryngeal carcinoma, carcinoma of gastric cardia, gastric cancer.This medicated bag is drawn together: Radix Ginseng, the Rhizoma Pinelliae, Flos Caryophylli, the Radix Aucklandiae, Fructus Aurantii Immaturus, Sal Ammoniacus, Fructus Trichosanthis, whitish honey, Calculus Bovis, Hedyotidis Diffusae, Herba euphorbiae lunulatae and use water as decoct.This medicine can play benefiting qi and nourishing blood simultaneously, resolving phlegm and dissipating blood stasis, the effect of heat-clearing and toxic substances removing and laxation relieving constipation, remarkable to treating above-mentioned curative effect of disease, and this medicine has curative effect preferably also to other diseases as hepatocarcinoma, pulmonary carcinoma, cervical cancer, breast carcinoma, malignant lymphoma, chronic pharyngitis, esophagitis and gastritis.
Description
The present invention relates to have the oral liquid of treatment disease effect, be specifically related to a kind of gullet oral liquid with special effect based on treatment esophageal carcinoma, laryngeal carcinoma, carcinoma of gastric cardia, gastric cancer.
With regard to modern medicine medical science technology, at present diseases such as treatment esophageal carcinoma, carcinoma of gastric cardia and gastric cancer also there is not ideal medicine, as the mitomycin injection of present use, FUFANG TIANXIAN JIAONANG, oral liquid 851 all can not reach ideal effect.For example to control these sick remission rates be 1.2% to FUFANG TIANXIAN JIAONANG, and improvement rate is 2%, and coefficient of stabilization is 77%; Routine again its side effect of mitomycin is big, and therapeutic effect is also undesirable.Aspect Chinese herbal medicine, also there are some to treat the proved recipe of this class disease, for example " Chinese medicine is cured in the esophageal carcinoma one example report (leaf is bright; the 40th page of " Anhui Chinese Medicine College journal " 1986 the 5th the 1st phase of volume) patient's Wang Dinghua is adopted stage by stage multi-treatment; the last stage adopts " big Rhizoma Pinelliae Tonga flavor " reach " cancer that disappears 101 soft gelatin capsules "; after-stage adopts distinguish the flavor of medicines and continue to join clothes " cancer that disappears 101 soft gelatin capsules " of Radix Rehmanniae etc. 10; be about 9 months treatment phase altogether, treat all right.But this therapeutic modality also has its weak point: (1) needs multiple stage by stage prescription treatment, medication is loaded down with trivial details and difficult grasp.(2) many to patient's clinical symptoms and the consideration of Signs factor, can not unify dispenser thereby be difficult for popularization.What treated is to accumulate type gastric cancer in a kind of noxious dampness, little to the therapeutic effect of other five types of gastric cancer to also have Gong Shi in " gastric cancer Chinese traditional treatment progress " (Ji Guang, discipline an ancient unit of weight, " the Jiangsu traditional Chinese medical science " second phase 40-42 page or leaf in 1989) " side three "; Zhang Shi utilization " cancer of going out soup " and " cancer of going out is loose " treatment digestive tract tumor 136 examples, gastric cancer 67 examples wherein, produce effects 4 examples as a result, effective 12 examples, alleviate 24 examples, invalid 27 examples, obvious effective rate is less than 60%, Zhang Shi fries in shallow oil water with Chinese honey locust (fruit) every day again, in addition is blended into a small amount of Mel with a certain amount of Radix Ginseng Rubra, the Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae and treats routine late gastric cancer patient's half a year and heal; In addition, Chen Shi utilization " the willow cancer is loose " and protein adsorption cantharidin are treated five routine late gastric cancer patients, reach alleviating pain, improve diet, the effect preferably of sleeping.All these medicines all have similar weak point, and promptly total obvious effective rate is not high and consider that the factor of patient's clinical symptoms is many, and it is still more loaded down with trivial details to unify dispenser and medication.
Therefore, the objective of the invention is to overcome above-mentioned weak point, a kind of high obvious effective rate that has is provided, and dependent patient clinical symptoms factor is little, can unify medicine that dispenser and medication be mainly used in diseases such as treatment esophageal carcinoma, laryngeal carcinoma, gastric cancer, carcinoma of gastric cardia easily and preparation method thereof.
Above-mentioned purpose of the present invention is achieved in that on the basis of present normally used ginseng class, the Rhizoma Pinelliae, Flos Caryophylli, adds the Radix Aucklandiae again, Fructus Aurantii Immaturus, Sal Ammoniacus, Fructus Trichosanthis, whitish honey, Calculus Bovis, Herba Hedyotidis Diffusae, Herba euphorbiae lunulatae and use water as decoct; The share of these ingredients is: Radix Ginseng 0.5-32 gram; Rhizoma Pinelliae 3-20 gram, Flos Caryophylli 3-9 gram, Radix Aucklandiae 1.5-9 gram; Fructus Aurantii Immaturus 3-9 gram; Sal Ammoniacus 0.3-0.6 gram, Fructus Trichosanthis 9-15 gram, whitish honey 9-32 gram; Calculus Bovis 0.3-0.6 gram; Herba Hedyotidis Diffusae 15-62 gram, 3000 to 5000 milliliters in Herba euphorbiae lunulatae 9-30 gram and water are made this oral liquid for treatment of esophagus disease.
Its manufacture method is: with above-mentioned each medicine composition; except that whitish honey and Calculus Bovis, grind altogether and be coarser powder; add 3000 to 5000 milliliters in water and add whitish honey 9-32 gram decocting and concentrating again and become 300 milliliters; through filter to such an extent that medicinal liquid also adds Calculus Bovis 0.3-0.6 gram therein with 100 mesh sieves; after stirring evenly again by quantitative bottling, for example 100 milliliters every bottle.
Oral liquid for treatment of esophagus disease of the present invention is in long-term clinical practice, the medicine of obtaining through test many times with obvious anticancer effect, its characteristics are that prescription rationally, selected prescription can play tonification healthy energy simultaneously, the effect of resolving phlegm and dissipating blood stasis, heat-clearing and toxic substances removing and laxation relieving constipation, thereby this a kind of medicine can be treated polytype gastric cancer and multiple other cancers and plant medicine than him higher average obvious effective rate is arranged.This medicine is ideal to the therapeutic efficiency of esophageal carcinoma, laryngeal carcinoma, gastric cancer, carcinoma of gastric cardia, can play Stabilization for hepatocarcinoma, pulmonary carcinoma, cervical cancer, breast carcinoma, malignant lymphoma, for chronic pharyngitis, esophagitis and gastritis etc. curative effect is preferably arranged also in addition.Here the clinical efficacy with this oral liquid for treatment of esophagus disease treatment esophageal carcinoma, laryngeal carcinoma, carcinoma of gastric cardia and gastric cancer is summarized as following table:
| Treat routine number | Take a turn for the better | Alleviate | Stable | Invalid | Interrupt | Improvement rate in 10 days | |
| The esophageal carcinoma | 62 | 51 | 4 | 3 | 2 | 2 | 82.28%(51/62) |
| Laryngeal carcinoma | 53 | 39 | 5 | 7 | 1 | 1 | 73.58%(39/53) |
| Carcinoma of gastric cardia | 161 | 140 | 7 | 9 | 3 | 2 | 86.95%(140/161) |
| Gastric cancer | 49 | 35 | 5 | 6 | 2 | 1 | 71.42%(35/49) |
| Add up to | 325 | 265 | 21 | 25 | 8 | 6 | 81.53%(265/325) |
Drug effect and the more deep understanding of advantage for to oral liquid for treatment of esophagus disease of the present invention are further described in conjunction with the preferred embodiments of the present invention now.
Embodiment 1: with Radix Ginseng 3 grams; the Rhizoma Pinelliae 3 grams, Flos Caryophylli 9 grams, the Radix Aucklandiae 6 grams; Fructus Aurantii Immaturus 7 grams; Sal Ammoniacus 0.5 gram, Fructus Trichosanthis 9 grams, Herba Hedyotidis Diffusae 15 grams; Herba euphorbiae lunulatae 10 grams grind into coarser powder altogether; add 3300 milliliters in water and add whitish honey 24 gram decocting and concentrating and become 300 milliliters, after 100 mesh sieves filter medicinal liquid, add Calculus Bovis 0.3 gram more therein and stir evenly the back by every bottle of 100 milliliters of bottlings.
This medicine make the back for character little if, the oral liquid of sweet suffering.Its effect is drying dampness to eliminate phlegm, hard masses softening and resolving, benefiting qi and nourishing blood, heat-clearing and toxic substances removing and laxation relieving constipation.It cures mainly: the esophageal carcinoma, laryngeal carcinoma, gastric cancer, carcinoma of gastric cardia, can play Stabilization for hepatocarcinoma, pulmonary carcinoma, cervical cancer, breast carcinoma, malignant lymphoma, and for chronic pharyngitis, esophagitis, gastritis curative effect preferably be arranged also.Its usage is one bottle of each clothes, and every day three times, maximum can once be obeyed the 2-3 bottle, best decoction being taken warmly during clothes.
When utilizing " oral liquid for treatment of esophagus disease " medicine of this embodiment of the present invention to do test, the model case of treatment enumerate one as follows:
The elegant cloud of oil, woman, 62 years old, time: on February 15th, 90, address: Danyang, city, Heze, Shandong Province office king of medicine village.Check the state of an illness: esophagus stage casing 7cm filling defect, make the esophagus smear and find squamous cell carcinoma.Should be disconnected: esophageal carcinoma (squamous cell carcinoma).Treatment: through obeying this routine oral liquid for treatment of esophagus disease 4 kilograms of weight increase after 20 days, damaged place is kept to 3cm, takes all transference cures through one month treatment, can advance general food, the film making reexamine focus disappears substantially, is still living and in good health through investigating nearly 3 years time patient now.
Embodiment 2: with Radix Ginseng 15 grams; the Rhizoma Pinelliae 10 grams, Flos Caryophylli 9 grams, the Radix Aucklandiae 9 grams; Fructus Aurantii Immaturus 9 grams; Sal Ammoniacus 0.5 gram, Fructus Trichosanthis 12 grams, Herba Hedyotidis Diffusae 20 grams; Herba euphorbiae lunulatae 15 grams grind into coarser powder altogether; add 4500 milliliters in water and add whitish honey 30 gram decocting and concentrating and become 300 milliliters, after 100 mesh sieves filter medicinal liquid, add Calculus Bovis 0.4 gram more therein and stir evenly the back by every bottle of 100 milliliters of bottlings.Its usage is with the usage of embodiment 1.
Utilize " oral liquid for treatment of esophagus disease " medicine of this second embodiment to test, it is as follows to treat a model case:
Kong Fancheng, man, 67 years old, the address: Zheng Zhuanxiang white wax garden, Cao County, Shandong village, the hypomere cancer is about the 10cm filling defect in the trouble esophagus, takes this medicine after one day, the glossopharyngeum difficulty alleviates, but the influent stream food is treated after 30 days the damaged 4.5cm that is kept to, take this medicine after 45 days, all transference cures can advance general food, and film making check symptom disappears substantially.
In fact, imitate gullet oral liquid with this Room and treat to also have among the patient of these diseases and lived 7,8 years, even live surplus in the of ten year, there is the part patient to be healed entirely.
In sum, the oral liquid of this treatment of esophagus disease is owing to can play benefiting qi and nourishing blood simultaneously, resolving phlegm and dissipating blood stasis, the effect of heat-clearing and toxic substances removing and laxation relieving constipation, therefore only just can obtain very ideal curative effect aspect the diseases such as treatment esophageal carcinoma, laryngeal carcinoma, gastric cancer, carcinoma of gastric cardia with this medicine by oral easily, the patient who has is obeying this medicine after one day unexpectedly, and the state of an illness alleviates to some extent, the patient claims this medicine mystery, thereby this medicine is gained the name thus.The advantage of this medicine is summed up as follows: (1) is to the obvious effective rate height (improvement rate is about 70-80% in 10 days) of esophageal carcinoma, laryngeal carcinoma, gastric cancer, carcinoma of gastric cardia, and is also effective in cure to other multiple cancer and inflammation; (2) this medicine is pure Chinese herbal medicine and is water liquid, thereby has no side effect and taking convenience; (3) this medicine medicine source is abundant, and making is simple and cost is lower, thereby is easy to promote; (4) this medicine is cured the disease rapidly, but is taking back several days just produce effects.
Claims (2)
1; a kind of esophageal carcinoma that cures mainly; laryngeal carcinoma; " oral liquid for treatment of esophagus disease " medicine of carcinoma of gastric cardia and gastric cancer, it comprises ginseng class, the Rhizoma Pinelliae; Flos Caryophylli is characterized in that: this medicine also comprises the Radix Aucklandiae, Fructus Aurantii Immaturus; Sal Ammoniacus, Fructus Trichosanthis, whitish honey; Calculus Bovis; Herba Hedyotidis Diffusae, Herba euphorbiae lunulatae and use water as decoct, the share of these ingredients is: Radix Ginseng 0.5-32 gram; Rhizoma Pinelliae 3-20 gram; Flos Caryophylli 3-9 gram, Radix Aucklandiae 1.5-9 gram, Fructus Aurantii Immaturus 3-9 gram; Sal Ammoniacus 0.3-0.6 gram; Fructus Trichosanthis 9-15 gram, whitish honey 9-32 gram, Calculus Bovis 0.3-0.6 gram; Herba Hedyotidis Diffusae 15-62 gram, 3000 to 5000 milliliters in Herba euphorbiae lunulatae 9-30 gram and water.
2; a kind of esophageal carcinoma that cures mainly; laryngeal carcinoma; the manufacture method of " oral liquid for treatment of esophagus disease " medicine of carcinoma of gastric cardia and gastric cancer; it is characterized in that: with the medicine composition of following share: Radix Ginseng 0.5-32 gram; Rhizoma Pinelliae 3-20 gram; Flos Caryophylli 3-9 gram; Radix Aucklandiae 1.5-9 gram, Fructus Aurantii Immaturus 3-9 gram, Sal Ammoniacus 0.3-0.6 gram; Fructus Trichosanthis 9-15 gram; Herba Hedyotidis Diffusae 15-62 gram, Herba euphorbiae lunulatae 9-30 gram grinds altogether for coarser powder, adds 3000 to 5000 milliliters in water; and add white close 9-32 gram again; decocting and concentrating becomes 300 milliliters, through filter with 100 mesh sieves medicinal liquid, and add Calculus Bovis 0.3-0.6 gram therein; after stirring evenly again by quantitative bottling, for example 100 milliliters every bottle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93103912A CN1047084C (en) | 1993-03-30 | 1993-03-30 | Oral liquid for treatment of esophagus disease and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93103912A CN1047084C (en) | 1993-03-30 | 1993-03-30 | Oral liquid for treatment of esophagus disease and its preparing method |
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| Publication Number | Publication Date |
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| CN1077129A true CN1077129A (en) | 1993-10-13 |
| CN1047084C CN1047084C (en) | 1999-12-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN93103912A Expired - Fee Related CN1047084C (en) | 1993-03-30 | 1993-03-30 | Oral liquid for treatment of esophagus disease and its preparing method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999008994A1 (en) * | 1997-08-19 | 1999-02-25 | Peplin Biotech Pty. Ltd. | Anti-cancer compounds |
| US7378445B2 (en) | 2000-08-07 | 2008-05-27 | Peplin Research Pty. Ltd. | Treatment of prostate cancer |
| US7449492B2 (en) | 2000-06-07 | 2008-11-11 | Peplin Research Pty, Ltd. | Therapeutic agents—I |
| US8106092B2 (en) | 2004-12-13 | 2012-01-31 | Leo Laboratories Limited | Treatment of solid cancers |
-
1993
- 1993-03-30 CN CN93103912A patent/CN1047084C/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999008994A1 (en) * | 1997-08-19 | 1999-02-25 | Peplin Biotech Pty. Ltd. | Anti-cancer compounds |
| US6432452B1 (en) | 1997-08-19 | 2002-08-13 | Peplin Biotech Pty. Ltd. | Anti-cancer compounds |
| US6787161B2 (en) | 1997-08-19 | 2004-09-07 | Peplin Biotech Pty. Ltd. | Anti-cancer compounds |
| US6844013B2 (en) | 1997-08-19 | 2005-01-18 | Peplin Research Pty Ltd | Methods of stimulating the immune system |
| US7410656B2 (en) | 1997-08-19 | 2008-08-12 | Peplin Research Pty. Ltd. | Anti-cancer compounds |
| US7449492B2 (en) | 2000-06-07 | 2008-11-11 | Peplin Research Pty, Ltd. | Therapeutic agents—I |
| US7838555B2 (en) | 2000-06-07 | 2010-11-23 | Peplin Research Pty Ltd | Macrocyclic diterpenes for the treatment and prophylaxis of acne vulgaris |
| US9314458B2 (en) | 2000-06-07 | 2016-04-19 | Leo Laboratories Limited | Topical use of ingenol-3-angelate or a salt thereof to treat skin cancer |
| US7378445B2 (en) | 2000-08-07 | 2008-05-27 | Peplin Research Pty. Ltd. | Treatment of prostate cancer |
| US8106092B2 (en) | 2004-12-13 | 2012-01-31 | Leo Laboratories Limited | Treatment of solid cancers |
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| Publication number | Publication date |
|---|---|
| CN1047084C (en) | 1999-12-08 |
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