CN107703108A - Sample testing apparatus and in-vitro diagnosis equipment - Google Patents
Sample testing apparatus and in-vitro diagnosis equipment Download PDFInfo
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- CN107703108A CN107703108A CN201710522288.2A CN201710522288A CN107703108A CN 107703108 A CN107703108 A CN 107703108A CN 201710522288 A CN201710522288 A CN 201710522288A CN 107703108 A CN107703108 A CN 107703108A
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- 238000012360 testing method Methods 0.000 title claims abstract description 125
- 238000000338 in vitro Methods 0.000 title claims abstract description 13
- 238000003745 diagnosis Methods 0.000 title claims abstract description 12
- 238000001514 detection method Methods 0.000 claims abstract description 27
- 239000007788 liquid Substances 0.000 claims description 108
- 238000011049 filling Methods 0.000 claims description 38
- 239000002699 waste material Substances 0.000 claims description 38
- 238000002156 mixing Methods 0.000 claims description 35
- 239000000284 extract Substances 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 238000003780 insertion Methods 0.000 claims description 2
- 230000037431 insertion Effects 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 208000007578 phototoxic dermatitis Diseases 0.000 description 7
- 238000007789 sealing Methods 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 238000004140 cleaning Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000000605 extraction Methods 0.000 description 3
- 239000011324 bead Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000003086 colorant Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000012631 diagnostic technique Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/064—Stray light conditioning
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- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract
The invention discloses a kind of sample testing apparatus and in-vitro diagnosis equipment, sample testing apparatus includes：Housing, the bearing part in housing, for carrying out the detector of luminous detection to reaction cup；Wherein, bearing part is provided with holding tank, and the bottom land of holding tank is provided with supporting plate, and supporting plate, which is provided with, to be used to take the putting hole for putting reaction cup；Detector is hermetically connected with the shell, and housing, detector and can be relative with detector holding tank formed test chamber.Sample testing apparatus disclosed by the invention, realized using test chamber and reaction cup is blocked, influence of the light of enclosure interior to luminous detection is reduced, so as to improve the degree of accuracy of testing result.
Description
Technical field
The present invention relates to vitro diagnostic techniques field, more specifically to a kind of sample testing apparatus and in-vitro diagnosis
Equipment.
Background technology
In vitro in diagnostic field, luminous detection is the final link of pattern detection, and most important link.Due to hair
Light detection is that luminescent substance is detected, so requiring higher to the close photosensitiveness of sample testing apparatus.
At present, sample testing apparatus mainly includes：Housing, in housing and the bearing part of reaction cup is carried, positioned at shell
The detector of luminous detection is carried out in vivo and to reaction cup；Wherein, bearing part is provided with putting hole, and reaction cup, which is taken, is placed on putting hole
On, the major part of reaction cup is exposed in the inner chamber of housing, and detector is located at the side of reaction cup to realize the hair to reaction cup
Light detects.
The close photosensitiveness of existing housing is poor, light in housing be present, because the major part of reaction cup is exposed in the inner chamber of housing,
Cause the shadow in housing to ring luminous detection, cause the degree of accuracy of testing result relatively low.
In summary, luminous detection how is carried out, is current those skilled in the art to improve the degree of accuracy of testing result
Urgent problem to be solved.
The content of the invention
It is an object of the invention to provide a kind of sample testing apparatus, to improve the degree of accuracy of testing result.The present invention's is another
One purpose is to provide a kind of in-vitro diagnosis equipment with above-mentioned sample testing apparatus.
To achieve these goals, the present invention provides following technical scheme：
A kind of sample testing apparatus, including：Housing, the bearing part in the housing, for sending out reaction cup
The detector of light detection；Wherein,
The bearing part is provided with holding tank, and the bottom land of the holding tank is provided with supporting plate, and the supporting plate, which is provided with, to be used to take
Put the putting hole of the reaction cup；
The detector is connected with the housing seal, and the housing, the detector and can be with the detector
The test chamber that the relative holding tank is formed.
Preferably, the detector includes：Mounting seat, the detector body being tightly connected with the mounting seat；Wherein, institute
Mounting seat is stated to be connected with the housing seal.
Preferably, the detector is located at the outside of the housing.
Preferably, the bearing part is integral type structure.
Preferably, the test chamber is closing chamber.
Preferably, the groove bottom of the holding tank is cambered surface.
Preferably, the holding tank at least two, and along the circumferentially distributed of the bearing part；
The sample testing apparatus also includes the first driving part, and first driving part drives the bearing part around it
Axis rotates.
Preferably, there is the sample testing apparatus reaction cup being sequentially distributed to load position, the first exciting liquid filling position, mix
Even position, wait position, the second exciting liquid filling position and reaction cup unloading position；
Wherein, the detector is located at second exciting liquid filling position, and the sample testing apparatus also includes：It is arranged at
The mixing module for mixing position, two be respectively arranged at first exciting liquid filling position and second exciting liquid filling position
Exciting liquid filling module；The housing loads position provided with hole is put into the reaction cup, and the housing unloads in the reaction cup
Carry position and be provided with falling hole.
Preferably, the putting hole has the opening towards the holding tank notch, and the reaction cup unloading is positioned at described
The open side of putting hole deviates the bearing part；
The sample testing apparatus also includes the unloading push piece being arranged on the housing, and the unloading push piece can be by institute
The reaction cup for stating a upper station for reaction cup unloading position pushes away the putting hole and the reaction cup is led into the reaction cup and unloads
Carry position.
Preferably, the holding tank has the resigning breach for the unloading push piece insertion.
Preferably, the sample testing apparatus also has reaction cup position to be loaded, and the reaction cup position to be loaded is located at institute
State in the rotary motion trace of bearing part, and the unloading push piece is located at the bottom of reaction cup position to be loaded.
Preferably, the sample testing apparatus also includes：Limit the anti-rotation knot that the reaction cup of the mixing position rotates
Structure, the anti-rotation structure are arranged at the housing.
Preferably, the anti-rotation structure is abutted described mixed to limit by the side wall of the reaction cup with the mixing position
The reaction cup of even position rotates, and the anti-rotation structure can be along the radial deformation of the putting hole of the mixing position.
Preferably, the anti-rotation structure includes：Anti-turn spring, the fitting being connected with the anti-turn spring；Wherein, it is described
Anti-turn spring is connected with the housing, and the fitting is used to abut with the reaction cup of the mixing position.
Preferably, the sample testing apparatus also includes：It is arranged on the housing and described put can be opened and closed
Enter the cover plate in hole.
Preferably, the exciting liquid filling module includes：Excite liquid supplying device, exciting liquid shower nozzle, waste collecting device,
Excite what liquid supplying device connected to excite liquid pipeline with described；
Wherein, the exciting liquid shower nozzle and the waste collecting device excite liquid pipeline to be connected by triple valve with described,
And when the triple valve is in the first valve position, it is described to excite liquid pipeline to be connected with the exciting liquid shower nozzle；When the triple valve
It is described to excite liquid pipeline to be connected with the waste collecting device during in the second valve position.
Preferably, also with being respectively positioned on, second exciting liquid fills position to the sample testing apparatus and the reaction cup is unloaded
Carry the waste liquid position to be extracted between position and waste liquid extracts position；The waste liquid position to be extracted and waste liquid extraction position are respectively positioned on described
In the rotary motion trace of bearing part；The sample testing apparatus also includes being arranged at the waste liquid abstraction module that the waste liquid extracts position.
Sample testing apparatus provided by the invention, by setting holding tank on the load bearing member, and housing seals with detector
Connection, test chamber is formed using housing, detector and the holding tank relative with the detector, is placed due to having in holding tank
Hole, then take and be put in the reaction cup of putting hole and also be located in test chamber, then test chamber realizes blocks to reaction cup, reduces shell
Influence of the light in internal portion to luminous detection, so as to improve the degree of accuracy of testing result.
Based on the sample testing apparatus of above-mentioned offer, present invention also offers a kind of in-vitro diagnosis equipment, the in-vitro diagnosis
Equipment includes sample testing apparatus, and the sample testing apparatus is the sample testing apparatus described in above-mentioned any one.
Brief description of the drawings
Technical scheme in order to illustrate the embodiments of the present invention more clearly, below will be to embodiment or description of the prior art
In the required accompanying drawing used be briefly described, it should be apparent that, drawings in the following description be only the present invention implementation
Example, for those of ordinary skill in the art, on the premise of not paying creative work, can also be according to the accompanying drawing of offer
Obtain other accompanying drawings.
Fig. 1 is the structural representation of sample testing apparatus provided in an embodiment of the present invention；
Fig. 2 is the station schematic layout pattern of sample testing apparatus provided in an embodiment of the present invention；
Fig. 3 is the structural representation of bearing part in sample testing apparatus provided in an embodiment of the present invention；
Fig. 4 is the structural representation of bearing part and unloading push piece in sample testing apparatus provided in an embodiment of the present invention；
Fig. 5 is the structural representation of anti-rotation structure in sample testing apparatus provided in an embodiment of the present invention；
Fig. 6 is the schematic diagram of test chamber in sample testing apparatus provided in an embodiment of the present invention.
Embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Site preparation describes, it is clear that described embodiment is only part of the embodiment of the present invention, rather than whole embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art are obtained every other under the premise of creative work is not made
Embodiment, belong to the scope of protection of the invention.
As shown in figures 1 to 6, sample testing apparatus provided in an embodiment of the present invention, including：Housing, the carrying in housing
Part 13, and for carrying out the detector of luminous detection to reaction cup 14.
Above-mentioned bearing part 13 is provided with holding tank 22, and the bottom land of the holding tank 22 is provided with supporting plate 23, and the supporting plate 23 is provided with
The putting hole 24 of reaction cup 14 is put for taking.
It is understood that the bottom land of holding tank 22 and the notch of holding tank 22 are relative, the notch of holding tank 22 can direction
The axis of bearing part 13, it can also deviate from the axis of bearing part 13；The axial direction of putting hole 24 is the thickness direction of supporting plate 23；And
The depth direction for being axially perpendicular to holding tank 22 of putting hole 24, or the axial direction of putting hole 24 and holding tank 22 depth direction it
Between there is angle, the angle is more than zero degree.
Above-mentioned detector is connected with above-mentioned housing seal, and above-mentioned housing, detector and can be relative with the detector
The test chamber that holding tank 22 is formed, as shown in Figure 6.
It is understood that detector connects with housing seal, the sealing structure of detector and housing can regard detection as
A part for device or a part for housing.
Preferably, above-mentioned detector is hermetically connected with the shell by sealing ring.Certainly, detector also may be selected with housing to lead to
The sealed connection of other sealing structures is crossed, the embodiment of the present invention is not limited this.
Sample testing apparatus provided in an embodiment of the present invention, by bearing part 13 set holding tank 22, detector with
Housing seal connects, and test chamber is formed using housing, detector and the holding tank 22 relative with the detector, due to holding tank
There is putting hole 24 in 22, then take and be put in the reaction cup 14 of putting hole 24 and also be located in test chamber, then test chamber is realized to anti-
Blocking for cup 14 is answered, influence of the light of enclosure interior to luminous detection is reduced, so as to improve the degree of accuracy of testing result.
In order to improve the close photosensitiveness of test chamber, above-mentioned detector includes：Mounting seat 19, and be tightly connected with the mounting seat 19
Detector body 1；Wherein, mounting seat 19 is hermetically connected with the shell, then housing, the and of mounting seat 19 being hermetically connected with the shell
The holding tank 22 relative with the mounting seat 19 forms test chamber.
Preferably, above-mentioned detector body 1 is tightly connected with mounting seat 19 by the second sealing ring 20, as shown in Figure 6.When
So, also optional detector body 1 is tightly connected with mounting seat 19 by other sealing structures, and the embodiment of the present invention is not limited this
It is fixed.
Preferably, mounting seat 19 is black, further reduces influence of the light of enclosure interior to luminous detection, further
Improve the degree of accuracy of testing result.
In order to reduce the volume of whole sample testing apparatus, above-mentioned detector is located at the outside of housing, such as Fig. 1 and Fig. 6 institutes
Show.It is understood that now holding tank 22 is opened on the outer wall of bearing part 13, the notch of holding tank 22 deviates from bearing part 13
Axis.So, the volume of bearing part 13 can suitably be reduced, so as to reduce the volume of whole sample testing apparatus；Together
When, also allow for forming test chamber, be easy to improve the closure of test chamber.
Preferably, above-mentioned bearing part 13 is integral type structure, as shown in figure 3, simplifying production, be it also avoid because part connects
Connect and caused light leak situation, improve block effect of the holding tank 22 to reaction cup 14.
Further, above-mentioned bearing part 13 is integral type injection structure.Certainly, bearing part 13 also may be selected is other one
Formula structure, it is not limited to this.
Preferably, above-mentioned test chamber is closing chamber.It is understood that housing is tightly connected with holding tank 22, detector
It is hermetically connected with the shell.So, test chamber blocking to reaction cup 14 is further increased, then further increases testing result
The degree of accuracy.
In above-mentioned sample testing apparatus, for the concrete structure of housing, it is designed according to being actually needed.In order to facilitate peace
Dress, above-mentioned housing include the upper casing 8 and lower casing 9 being tightly connected；Wherein, detector is tightly connected with lower casing 9, such as Fig. 1 and Fig. 6 institutes
Show.Preferably, upper casing 8 and lower casing 9 are tightly connected by the first sealing ring 18.Certainly, upper casing 8 also may be selected and lower casing 9 passes through
Other seals or sealing structure are tightly connected, it is not limited to this.
In order to facilitate producing and manufacturing, prioritizing selection test chamber does not have closure, i.e., the light in housing can enter detection
Intracavitary, now, in order to which the illumination reduced in test chamber is mapped in reaction cup 14, the groove bottom of prioritizing selection holding tank 22 is arc
Face, as shown in Figure 3 and Figure 4.So, light reflects after reaching the groove bottom of holding tank 22, reduces and is irradiated to reaction cup 14
On light, improve the degree of accuracy of testing result.
Preferably, above-mentioned bearing part 13 and housing are black.Due to black surface not reflected light, then further reduce
Influence of the light of enclosure interior to luminous detection, further increases the degree of accuracy of testing result.
Certainly, above-mentioned bearing part 13 and housing also may be selected is other colors, it is not limited to above-described embodiment.
In above-mentioned sample testing apparatus, for the number of holding tank 22, it is designed according to being actually needed.Preferably, on
State holding tank 22 at least two, and along the circumferentially distributed of bearing part 13.It is understood that putting hole 24 and holding tank 22 1
One correspondence.
Relative motion occurs for above-mentioned bearing part 13 and detector, you can realization is entered to the reaction cup 14 in each holding tank 22
Row detection.For the ease of operation, prioritizing selection bearing part 13 moves, detector and housing fixed setting.Specifically, above-mentioned sample
Detection means also includes the first driving part 3, and the first driving part 3 driving bearing part 13 is rotatable around its axis.
Preferably, above-mentioned first driving part 3 is motor.Certainly, above-mentioned first driving part 3 also may be selected is other portions
Part, it is not limited to this.
If above-mentioned sample testing apparatus can individually complete the detection of sample, above-mentioned sample testing apparatus has to be divided successively
The reaction cup of cloth load position A1, the first exciting liquid filling position A2, mix position A3, wait position A4, the second exciting liquid filling position A5 and
Reaction cup unloads position A8, as shown in Figure 2.Bearing part 13 is driven to rotate by the first driving part 3, to realize reaction cup 14 not
Shifted between station.
It is understood that above-mentioned detector is located at the second exciting liquid filling position A5.Above-mentioned sample testing apparatus also includes：
The mixing module 12, two for being arranged at mixing position A3 is respectively arranged at the first exciting liquid filling position A2 and the second exciting liquid filling position
A5 exciting liquid filling module.
Above-mentioned mixing module 12 is used to mix the liquid in the reaction cup 14 for mixing position A3 and magnetic bead, and two exciting liquids add
Injection molding block is respectively the first exciting liquid filling module 7 and second exciting liquid filling module 4, and the first exciting liquid filling module 7 is located at
First exciting liquid, which fills position A2 and filled to the first exciting liquid in position A2 reaction cup 14, fills the first exciting liquid, the second exciting liquid
Filling module 4, which is located at the second exciting liquid filling position A5 and fills filling second in position A5 reaction cup 14 to the second exciting liquid, to be excited
Liquid.
In order to realize the loading of reaction cup 14 and unloading and improve the close photosensitiveness of housing, above-mentioned housing loads in reaction cup
Position A1, which is provided with, is put into hole, and above-mentioned housing is provided with falling hole in reaction cup unloading position A8.Specifically, hole is put into certainly to take reaction cup 14
It is put in reaction cup to load on position A1 putting hole 24, the autoreaction cup of reaction cup 14 unloading position A8 falling hole drops.
Preferably, the shell of above-mentioned mixing module 12 is hermetically connected with the shell, and improves the close of whole sample testing apparatus
Optical property.
The detection of detector is influenceed in order to avoid being put into hole, above-mentioned second exciting liquid filling position A5 and reaction cup load position A1
Relatively, as shown in Fig. 2 i.e. above-mentioned second exciting liquid filling position A5 and reaction cup load position A1 line and the diameter of bearing part 13
Collinearly.
In above-mentioned sample testing apparatus, reaction cup unloading position A8 is located on the movement locus of bearing part 13, i.e., reaction cup is unloaded
Position A8 is carried to be usually located on bearing part 13.Because reaction cup 14 and bearing part 13 have matching relationship, then in uninstall process, hold
Holder 13 is easier to interfere reaction cup 14, influences to unload.In order to avoid there is above mentioned problem, above-mentioned reaction cup unloading position A8 is arranged on
Deviate the position of the rotary motion trace of bearing part 13, reaction cup loads position A1, the first exciting liquid filling position A2, mixes position A3, waits
Position A4, the second exciting liquid filling position A5 are respectively positioned in the rotary motion trace of bearing part 13.
Now, the unloading of reaction cup 14 can not only be completed by bearing part 13, it is necessary to which reaction cup is unloaded into position by miscellaneous part
The reaction cup 14 of an A8 upper station moves to reaction cup unloading position A8, and the part can be manipulator or other accessories.
For the ease of unloading, above-mentioned putting hole 24 have towards the notch of holding tank 22 opening, reaction cup unload position A8 in
The open side of putting hole 24 deviates bearing part 13；Above-mentioned sample testing apparatus also includes the unloading push piece 15 being arranged on housing,
The reaction cup 14 for the upper station that reaction cup can be unloaded position A8 by above-mentioned unloading push piece 15 pushes away putting hole 24 and reacts this
Cup 14 leads to reaction cup unloading position A8, as shown in Figure 4.
Specifically, when housing includes the upper casing 8 and lower casing 9 that are tightly connected, unloading push piece 15 is arranged at lower casing 9.
It is understood that reaction cup unloads position A8 not on bearing part 13.With the motion of bearing part 13, putting hole 24
A reaction cup unloading position A8 upper station is reached with the reaction cup 14 on putting hole 24；Unloading push piece 15 pushes away reaction cup 14 instead
Answer the putting hole 24 of a cup unloading position A8 upper station；Reaction cup 14 departs from putting hole 24 from the opening of putting hole 24.
In above-mentioned sample testing apparatus, putting hole 24 has opening, reaction cup is unloaded position A8 in the opening of putting hole 24
Lateral deviation pushes away putting hole from bearing part 13, using the reaction cup 14 for the upper station for unloading push piece 15 by reaction cup 14 and unloading station
24 and by the reaction cup 14 lead to reaction cup unloading position A8, then realize outside bearing part 13 carry out reaction cup 14 unloading, from
And avoiding bearing part 13 influences the unloading of reaction cup 14.
In order to reduce volume, the notch of prioritizing selection holding tank 22 deviates from the pivot center of bearing part 13, i.e. putting hole 24
Opening away from bearing part 13 pivot center.Now, reaction cup unloading position A8 is located at the outside of bearing part 13.
Above-mentioned holding tank 22 can be groove, also not be groove, for the ease of unloading reaction cup 14, prioritizing selection holding tank
22 be groove, i.e. both ends of the holding tank 22 along the axial direction of putting hole 24 have port.
Putting hole 24, above-mentioned holding tank are pushed away for the ease of reaction cup 14 to be unloaded to the reaction cup 14 of a upper station for station
22 have the resigning breach 25 inserted for unloading push piece 15, as shown in Figure 3 and Figure 4.
Size and formation for resigning breach 25, according to unloading push piece 15 be designed, the embodiment of the present invention to this not
Limit.Certainly, also optional holding tank 22 is shorter, and holding tank 22 is stretched out in the bottom of reaction cup 14, then now, can be without hold
Receive and resigning breach 25 is set on groove 22.
Preferably, above-mentioned unloading push piece 15 has the reaction cup 14 for the upper station for being used for driving a reaction cup unloading position A8 de-
From the promotion plane of putting hole 24.Certainly, also may be selected, using promoting curved surface to replace promoting plane, to be not limited merely to above-mentioned reality
Apply example.
Further, above-mentioned promotion plane forms passage, passage connection reaction cup unloading position A8 and reaction cup with housing
Unload a position A8 upper station.
For the ease of unloading, having positioned at reaction cup unloading position A8 one end for above-mentioned unloading push piece 15 is used for spacing reaction
The limited impression of cup 14.So, limited impression is realized to the spacing of reaction cup 14, ensure that reaction cup 14 reaches reaction cup and unloaded
Alignd after carrying position A8 with falling hole, realize unloading.
Above-mentioned limited impression can be arc, or other shapes, be designed according to being actually needed.
Preferably, above-mentioned sample testing apparatus also there is reaction cup position A9 to be loaded, reaction cup position A9 to be loaded to be located at
In the rotary motion trace of bearing part 13, and the unloading push piece 15 is located at reaction cup position A9 to be loaded bottom.It is understood that edge
The rotary motion trace of bearing part 13, reaction cup position A9 to be loaded is located at waste liquid and extracted between position A7 and reaction cup loading position A1, such as Fig. 2
It is shown.
Above-mentioned sample testing apparatus adds station, and the upper station for avoiding reaction cup unloading position A8 unloads with reaction cup
Position A8 next station it is in larger distance, so as to reduce the distance between adjacent stations, and then reduce the body of bearing part 13
Product, accordingly, also reduces the volume of whole sample testing apparatus.
Further, the radial distribution of reaction cup unloading position A8 and reaction cup position A9 to be loaded along bearing part 13.Certainly,
Reaction cup may be selected and unload position A8 and reaction cup position A9 to be loaded along other directional spredings, it is not limited to above-described embodiment.
In order to improve unloading reliability, above-mentioned unloading push piece 15 is used for the housing for being fixed on sample testing apparatus.
The other shapes such as above-mentioned unloading push piece 15 is plate-like or block.Concrete shape for unloading push piece 15, according to reality
Border is needed to be designed, and the embodiment of the present invention is not limited this.
In above-mentioned sample testing apparatus, it is double helix evenly mixing device that prioritizing selection, which mixes module 12,.Position A3 is being mixed, is being mixed
Module 12 drives reaction cup 14 to swing and vibrate, to mix the liquid and magnetic bead in reaction cup 14.Taken and be placed on due to reaction cup 14
On putting hole 24, then from blending process, reaction cup 14 is easier to rotate, and influences to mix.In order to avoid there is above mentioned problem,
Above-mentioned sample testing apparatus also includes anti-rotation structure, and the anti-rotation structure is arranged at housing, and the anti-rotation structure can limit mixing
Position A3 reaction cup 14 rotates.
Specifically, when housing includes the upper casing 8 and lower casing 9 that are tightly connected, anti-rotation structure is arranged at lower casing 9.
Above-mentioned sample testing apparatus, by setting anti-rotation structure on housing, limited using anti-rotation structure and mix position A3's
Reaction cup 14 rotates, and is mixing position A3 rotations so as to avoid reaction cup 14, and then avoid because reaction cup 14 is mixing position A3
Rotate and influence testing result.
The reaction cup 14 that above-mentioned anti-rotation structure can limit mixing position A3 rotates, and at least two modes be present, for example, anti-rotation
Structure is abutted by the side wall of the reaction cup 14 with mixing position A3 to be rotated with limiting mixing position A3 reaction cup 14, or anti-rotation knot
Structure is abutted by the flange top surface of the reaction cup 14 with mixing position A3 to be rotated with limiting mixing position A3 reaction cup 14.For the ease of
Realize, prioritizing selection the former.
The side wall of reaction cup 14 of the above-mentioned anti-rotation structure with mixing position A3 abuts, for the ease of abutting and strengthening abutting power
Degree, above-mentioned anti-rotation structure can be along the radial deformations for the putting hole 24 for mixing position A3.For example, anti-rotation structure is elastic bumps, or
Person's spring etc..
In order to increase contact area, above-mentioned anti-rotation structure includes：Anti-turn spring 17, and the abutting being connected with anti-turn spring 17
Part 16；Wherein, anti-turn spring 17 is connected with housing, and fitting 16 is used to abut with mixing position A3 reaction cup 14, such as Fig. 5 institutes
Show.
It is understood that anti-turn spring 17 can be along the radial deformation for the putting hole 24 for mixing position A3, i.e. anti-turn spring
17 axial direction is the radial direction for the putting hole 24 for mixing position A3.The radial direction for mixing position A3 putting hole 24 as mixes the reaction for being
The radial direction of cup 14.
Above-mentioned anti-turn spring 17 is easier to the axial direction for deviateing anti-turn spring 17 in deformation process, influences the limit of anti-rotation structure
Position, in order to avoid there is above mentioned problem, above-mentioned housing is provided with guide protrusions, and anti-turn spring 17 is coated at guide protrusions.It can manage
Solution, guide protrusions are axially extending along anti-turn spring 17.So, guide protrusions realize the guiding to anti-turn spring 17,
Anti-turn spring 17 is avoided to shift in deformation process.
It should be noted that there is pre-determined distance, to ensure fitting 16 along anti-rotation between guide protrusions and fitting 16
The axial movement of spring 17.
Above-mentioned guide protrusions, can be cylindric, or rectangular-shape, for the ease of being oriented to, prioritizing selection guide protrusions
It is cylindrical.
Above-mentioned anti-turn spring 17 is securable to housing, can also be abutted with housing.In order to simplify installation, above-mentioned anti-turn spring 17
One end abutted with housing, the other end and the fitting 16 of anti-turn spring 17 are fixedly linked.
Formation for fitting 16, it can be designed according to being actually needed, for example, fitting 16 is in bulk, tabular etc.,
The embodiment of the present invention is not limited this.
In order to increase bearing surface, limit effect is improved, above-mentioned anti-rotation structure is used to abut with mixing position A3 reaction cup 14
Face be cambered surface.It is understood that cambered surface is bonded with the circumferential side wall of reaction cup 14.
In order to improve spacing reliability, the putting hole 24 has opening, and anti-rotation structure is positioned at the putting hole for mixing position A3
24 opening, as shown in Figure 5.
In above-mentioned anti-rotation component, facilitate anti-rotation structure and abut reaction cup 14；Meanwhile putting hole 24 is to the work of reaction cup 14
Firmly can be in same level to the abutting power of reaction cup 14 with anti-rotation structure, or putting hole 24 is to the active force of reaction cup 14
It is smaller to the difference in height of the abutting power of reaction cup 14 with anti-rotation structure, the uniform force of reaction cup 14 is improved, so as to improve
Spacing reliability.
Because reaction cup 14 has flange, reaction cup 14 is taken by the flange and is placed on putting hole 24, in order to avoid anti-rotation knot
Interfered between structure and flange, above-mentioned anti-rotation structure has the bit architecture that allows for being used for that space to be provided to the flange of reaction cup 14.
This allows bit architecture to be slot to make way, resigning mouthful etc., and the embodiment of the present invention is not limited this.
Preferably, above-mentioned sample testing apparatus also includes：It is arranged on housing and the lid for being put into hole can be opened and closed
Plate 6.So, the light and dust for avoiding outside enter in housing from hole is put into, and improve the closing of whole sample testing apparatus
Property.
Above-mentioned cover plate 6 is a flat board, no open-celled structure；Or above-mentioned cover plate 6 has through hole, when the through hole is with being put into
When hole is alignd, that is, open and be put into hole.Above-mentioned cover plate 6 can realize the opening for being put into hole by the motion such as rotate or move linearly
And closing, the embodiment of the present invention are not limited this.
Further, above-mentioned sample testing apparatus also includes the driving part of sensor 21 and second, wherein, sensor 21 is examined
Survey reaction cup 14 and load whether position has reaction cup 14, the second driving part driving cover plate 6 moves；The drive division of sensor 21 and second
Part signal connects, and when reaction cup 14, which loads position, reaction cup 14, the second driving part driving cover plate 6, which is closed, is put into hole；When anti-
When answering the cup 14 to load the reactionless cup 14 in position, the second driving part driving cover plate 6, which is opened, is put into hole.
Above-mentioned sample testing apparatus, realize and be put into automatically opening up and closing automatically for hole, improve automation performance.
Above-mentioned second driving part can be electromagnet, motor or cylinder, and the embodiment of the present invention is not limited this.
Preferably, above-mentioned exciting liquid filling module includes：Excite liquid supplying device, exciting liquid shower nozzle, waste collecting device,
With exciting what liquid supplying device connected to excite liquid pipeline；Wherein, exciting liquid shower nozzle and waste collecting device by triple valve and swash
Lotion pipeline is connected, and when triple valve is in the first valve position, excites liquid pipeline to be connected with the exciting liquid shower nozzle；Work as triple valve
During in the second valve position, liquid pipeline is excited to be connected with waste collecting device.
It is understood that the first exciting liquid filling module 7 is identical with the structure of the second exciting liquid filling module 4, simply
Present position is different, and the exciting liquid of filling is different.
Specifically, in normal experimentation, triple valve is in the first valve position, excites liquid pipeline to connect with the exciting liquid shower nozzle
It is logical, exciting liquid injection reaction cup 14；When needing to clean or filling pipeline, switching three-way valve so that triple valve is in second
Valve position, liquid flows through exciting liquid pipeline, and the liquid after cleaning is directly discharged into waste collecting device, realizes and excites liquid pipeline
Filling and cleaning need not use reaction cup 14；No pipe cleaning is also achieved to fill without pipe.
In order to prevent the harm of human body liquid in reaction cup 14, before the unloading of reaction cup 14, by the liquid in reaction cup 14
Take away, specifically, above-mentioned sample testing apparatus also have be respectively positioned on the second exciting liquid filling position A5 and reaction cup unloading position A8 it
Between waste liquid position A6 to be extracted, waste liquid extract position A7；Waste liquid position A6 to be extracted, waste liquid extract the rotation that position A7 is located at bearing part 13
On track；Sample testing apparatus also includes being arranged at the waste liquid abstraction module 5 that waste liquid extracts position A7.
It is understood that along the rotary motion trace of bearing part 13, reaction cup loads position A1, the first exciting liquid fills position A2,
Mix position A3, wait position A4, the second exciting liquid filling position A5, waste liquid position A6 to be extracted, waste liquid extraction position A7, reaction cup to wait to load
Position A9 is sequentially distributed, as shown in Figure 2.
Preferably, above-mentioned waste liquid abstraction module 5 includes：Waste suction liquid pin, driving waste suction liquid pin vertically move back and forth
Linear electric motors；Wherein, waste suction liquid pin draws waste liquid by negative pressure device.Above-mentioned linear electric motors can be replaced by other driving parts,
Certainly, above-mentioned waste liquid abstraction module 5 or other structures, it is not limited to above-described embodiment.
Above-mentioned sample testing apparatus is the cycle detector for integrating multiple functions, specifically, above-mentioned pattern detection
Device has close photosensitiveness, mixes and mix anti-rotation, isolation detection, waste liquid extraction, reaction cup without pipe filling, double helix without pipe cleaning
The functions such as 14 automatic unloadings, and above-mentioned sample testing apparatus, it is small volume, simple and compact for structure.
The close photosensitiveness of above-mentioned sample testing apparatus make use of two characteristics of light, and one is light along straightline propagation, another
It is black surface not reflected light.Gap between bearing part 13 and housing is smaller, and the close photosensitiveness of whole device is better, actually should
During, this can not limited according to the gap being actually needed between design bearing part 13 and housing, the embodiment of the present invention.
Above-mentioned sample testing apparatus, automatic detection is realized by control module control, specifically, sample testing apparatus is provided with
The control interface module 2 being connected with control module.
Preferably, above-mentioned sample testing apparatus also includes：Bottom plate 10, support the pillar 11 of the bottom plate 10；Wherein, housing position
In the top of bottom plate 10, mix module 12 and be installed on bottom plate 10.
Certainly, also may be selected other structures carry out supporing shell, for example with support base replace bottom plate 10 uh groan pillar 11, and
It is not limited to above-described embodiment.
The sample testing apparatus provided based on above-described embodiment, the embodiment of the present invention are additionally provided a kind of in-vitro diagnosis and set
Standby, the in-vitro diagnosis equipment detects including pattern detection, and the sample testing apparatus is the pattern detection dress described in above-described embodiment
Put.
Because above-mentioned sample testing apparatus has above-mentioned technique effect, above-mentioned in-vitro diagnosis equipment has above-mentioned pattern detection
Device, then above-mentioned in-vitro diagnosis equipment also there is corresponding technique effect, repeat no more herein.
The foregoing description of the disclosed embodiments, those skilled in the art are enable to realize or using the present invention.To this
A variety of modifications of a little embodiments will be apparent for a person skilled in the art, and generic principles defined herein can
Without departing from the spirit or scope of the present invention, to realize in other embodiments.Therefore, the present invention will not be limited
The embodiments shown herein is formed on, and is to fit to consistent with principles disclosed herein and features of novelty most wide
Scope.
Claims (18)
1. a kind of sample testing apparatus, including：Housing, the bearing part in the housing, for being lighted to reaction cup
The detector of detection；Characterized in that,
The bearing part is provided with holding tank, and the bottom land of the holding tank is provided with supporting plate, and the supporting plate, which is provided with, to be used to take to put institute
State the putting hole of reaction cup；
The detector is connected with the housing seal, and the housing, the detector and can be relative with the detector
The holding tank formed test chamber.
2. sample testing apparatus according to claim 1, it is characterised in that the detector includes：Mounting seat, it is and described
The detector body that mounting seat is tightly connected；Wherein, the mounting seat is connected with the housing seal.
3. sample testing apparatus according to claim 1, it is characterised in that the detector is located at the outer of the housing
Side.
4. sample testing apparatus according to claim 1, it is characterised in that the bearing part is integral type structure.
5. sample testing apparatus according to claim 1, it is characterised in that the test chamber is closing chamber.
6. sample testing apparatus according to claim 1, it is characterised in that the groove bottom of the holding tank is cambered surface.
7. according to the sample testing apparatus described in any one in claim 1-6, it is characterised in that the holding tank is at least
Two, and along the circumferentially distributed of the bearing part；
The sample testing apparatus also includes the first driving part, and first driving part drives the bearing part around its axis
Rotate.
8. the sample testing apparatus stated according to claim 7, it is characterised in that the sample testing apparatus has what is be sequentially distributed
Reaction cup loads position, the first exciting liquid filling position, mixes position, waits position, the second exciting liquid filling position and reaction cup unloading position；
Wherein, the detector is located at second exciting liquid filling position, and the sample testing apparatus also includes：It is arranged at described
Mix the mixings module of position, two be respectively arranged at the sharp of first exciting liquid filling position and second exciting liquid filling position
Lotion fills module；The housing loads position in the reaction cup and unloads position in the reaction cup provided with hole, the housing is put into
Provided with falling hole.
9. sample testing apparatus according to claim 8, it is characterised in that the putting hole has towards the holding tank
The opening of notch, the reaction cup unloading deviate the bearing part positioned at the open side of the putting hole；
The sample testing apparatus also includes being arranged at unloading push piece on the housing, the unloading push piece can will it is described instead
Answer the reaction cup of a upper station for cup unloading position to push away the putting hole and the reaction cup is led into the reaction cup and unload position.
10. sample testing apparatus according to claim 9, it is characterised in that the holding tank has to be pushed away for the unloading
The resigning breach of part insertion.
11. sample testing apparatus according to claim 9, it is characterised in that the sample testing apparatus also has reaction
Cup position to be loaded, the reaction cup position to be loaded are located in the rotary motion trace of the bearing part, and the unloading push piece is located at institute
State the bottom of reaction cup position to be loaded.
12. sample testing apparatus according to claim 8, it is characterised in that also include：Limit the described of the mixing position
The anti-rotation structure that reaction cup rotates, the anti-rotation structure are arranged at the housing.
13. sample testing apparatus according to claim 12, it is characterised in that the anti-rotation structure by with the mixing
The side wall of the reaction cup of position abuts to be rotated with limiting the reaction cup of the mixing position, and the anti-rotation structure being capable of edge
The radial deformation of the putting hole for mixing position.
14. sample testing apparatus according to claim 13, it is characterised in that the anti-rotation structure includes：Anti-turn spring,
The fitting being connected with the anti-turn spring；Wherein, the anti-turn spring is connected with the housing, and the fitting is used for and institute
State the reaction cup abutting for mixing position.
15. sample testing apparatus according to claim 8, it is characterised in that also include：It is arranged on the housing and energy
The cover plate in hole is put into described in enough opening and closing.
16. sample testing apparatus according to claim 8, it is characterised in that the exciting liquid filling module includes：Excite
Liquid supplying device, exciting liquid shower nozzle, waste collecting device, excite what liquid supplying device connected to excite liquid pipeline with described；
Wherein, the exciting liquid shower nozzle and the waste collecting device excite liquid pipeline to be connected by triple valve with described, and work as
It is described to excite liquid pipeline to be connected with the exciting liquid shower nozzle when triple valve is in the first valve position；When the triple valve is in
It is described to excite liquid pipeline to be connected with the waste collecting device during the second valve position.
17. sample testing apparatus according to claim 8, it is characterised in that also have and be respectively positioned on second exciting liquid
Fill the waste liquid position to be extracted between position and reaction cup unloading position and waste liquid extracts position；Waste liquid position to be extracted and described
Waste liquid extracts position and is respectively positioned in the rotary motion trace of the bearing part；The sample testing apparatus is also taken out including being arranged at the waste liquid
The waste liquid abstraction module of fetch bit.
18. a kind of in-vitro diagnosis equipment, including sample testing apparatus, it is characterised in that the sample testing apparatus is such as right
It is required that the sample testing apparatus in 1-17 described in any one.
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| CN201710522288.2A CN107703108B (en) | 2017-06-29 | 2017-06-29 | Sample detection device and in-vitro diagnosis equipment |
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| CN107703108B CN107703108B (en) | 2024-05-31 |
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