CN107698507A - A kind of preparation method of pentazocine intermediate - Google Patents
A kind of preparation method of pentazocine intermediate Download PDFInfo
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- CN107698507A CN107698507A CN201710956550.4A CN201710956550A CN107698507A CN 107698507 A CN107698507 A CN 107698507A CN 201710956550 A CN201710956550 A CN 201710956550A CN 107698507 A CN107698507 A CN 107698507A
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- VBPPYMWKPBBJJU-UHFFFAOYSA-N CC(C)(c1ccccc1)NC=O Chemical compound CC(C)(c1ccccc1)NC=O VBPPYMWKPBBJJU-UHFFFAOYSA-N 0.000 description 1
- CUBSNSGMZYJDLX-MRXNPFEDSA-N CC[C@H](c1ccccc1)[n+]1ccc(C)c(C)c1 Chemical compound CC[C@H](c1ccccc1)[n+]1ccc(C)c(C)c1 CUBSNSGMZYJDLX-MRXNPFEDSA-N 0.000 description 1
- DXESFJJJWBHLJX-KJXYMRNQSA-N C[C@@H]1[C@]2(C)c3cc(O)ccc3CC1NCC2 Chemical compound C[C@@H]1[C@]2(C)c3cc(O)ccc3CC1NCC2 DXESFJJJWBHLJX-KJXYMRNQSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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- C07B2200/07—Optical isomers
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Abstract
The invention discloses a kind of preparation method of pentazocine intermediate, belongs to pharmaceutical synthesis field, and the present invention uses simple synthetic method, synthesis of chiral intermediate, then obtain key intermediate () (2S, [2a by addition and the de- benzyl of hydrogenation, 6a, 11S]) 1,2,3,4,5, the alcohol of cis 6,11 2,6 methylene of dimethyl, 3 benzo azocine of 6 hexahydros 8, cost is low, and technique is simple, high income and product chiral purity is up to 98%.
Description
Technical field
The present invention relates to pharmaceutical synthesis field, particularly relates to prepare (-)-(2S, [2a, 6a, 11S]) -1,2,3,4,
A kind of preparation method of 5,6- hexahydros-cis -6,11- dimethyl -2,6- methylene -3- benzo azocine -8- alcohol
Background technology
Pentazocine, chemistry entitled (2R, 6R, 11R)-cis -1,2,3,4,5,6- hexahydro -6,11- dimethyl -3- (3-
Methyl-2-butene base) -2,6- methylene -3- benzo azocine -8- alcohol, its structure is as follows：
Listing is succeeded in developing by the primary group of stirling Charles Winslow of Britain by 1967, pentazocine is spreading out for benzmorphan
Biology, have excitement and the antagonism of mixture concurrently to opiate receptor, main exciting opioid kappa-receptor in neonatal rabbit can exciting σ during larger dose
Acceptor, there is partial agonist or weaker antagonism to μ acceptors.Pentazocine be applied in severe pain analgesia, face
Bed is widely used, and aids in analgesia, Postoperative Analgesia After, treatment of chronic pain, Pain Treatment applicable in such as art.For oral
Pentazocine tablet, it is currently the only orally available opiate receptor excitement antagonism analgestic.
In recent years, several domestic Pharma Inc.s succeeded in developing, and gradually began to use.The preparation flow of pentazocine be with
3,4- lutidines are raw material, are condensed with iodomethane and to methoxy-benzyl magnesium chloride, then after reduction, cyclization, protected
Shield property is acylated, demethylation and hydrolysis deprotection obtain key intermediate, finally reacts and produces with dimethyl bromopropene.
With the development of asymmetric chemistry, various chiral catalysts start the synthesis applied to pentazocine.Japan
M.Kitamura et al. carries out asymmetric hydrogenation using catalyst, generates the isomers of single configuration.The process route is deposited
Require high in reaction pressure, the shortcomings that catalyst is not easy to prepare, be difficult to apply to industrialized production (Tetrahedron
Letter：28(1987)4829-4832).
1993, Yves Genisson et al. carried out Stereo control alkylation instead with chiral pyridyl salt and grignard reagent
Answer, synthesize key intermediate (-) normetazocine of pentazocine, the asymmetric alkane of this route committed step pyridiniujm
Base yield only has 40%, and ee values are 82% (91%：9%), initiation material raw material 2,4- dinitroanilines belong to explosive
Material.
2012, Qiang chen et al. with asa-Prins cyclisation and intramolecular Friedel-Crafts react into
Go asymmetric syntheses, but this asymmetric syntheses is that mixture contains corresponding isomers, and route steps are more, yield is low, uses
The dangerous material such as metallic sodium, n-BuLi are arrived.
The content of the invention
Object of the present invention is to provide (-)-(2S, [2a, 6a, 11S]) -1,2,3,4,5,6- hexahydros-cis -6,
The synthetic method of 11- dimethyl -2,6- methylene -3- benzo azocine -8- alcohol, changes current pentazocine and passes through chiral resolution side
Yield that method faces is low, the wasting of resources, uses the present situation for easily making the conditions such as quick-fried material and high pressure and being difficult to industrialized production, we
Method obtains crucial chiral intermediate by methodology of organic synthesis, and high income, technique is simple, suitable for industrialized production；Save money
Source, reduce production cost.
To overcome problems of the prior art, the present invention uses simple synthetic method, synthesis of chiral intermediate, so
Afterwards key intermediate (-)-(2S, [2a, 6a, 11S]) -1 is obtained by addition and the de- benzyl of hydrogenation, 2,3,4,5,6- hexahydros-cis -
6,11- dimethyl -2,6- methylene -3- benzo azocine -8- alcohol, cost is low, and technique is simple, high income and product chiral purity height
Up to 98%.
This route totally four step, as shown in the following steps, whole process route raw material is cheap and easily-available, and cost is low, technique it is short and
Simply, easy to operate, total recovery is high.
(1) ring-opening reaction：Compound as shown in formula (2) is dissolved in collidine, and lithium bromide is dissolved in ether solvent, zero
It is lower 30-50 DEG C, bromination phosphorus reaction is added, obtains the compound as shown in formula (3)；
(2) coupling reaction：Compound as shown in formula (3) is reacted with the compound shown in formula (6) and sodium hydride, is obtained such as formula
(4) compound shown in；
(3) ring closure reaction：Compound as shown in formula (4) is in medium polyphosphoric acids, at 30-60 DEG C of temperature, with 4-
Ring-closure reaction occurs for methoxybenzene acetaldehyde, obtains chiral centre * C, the compound as shown in formula (5)；
(4) hydrogenation：Intermediate as shown in formula (5) passes through in the presence of Pd/C, hydrogenates de- benzyl and obtains such as formula (1) institute
The target product shown.
In described step (1), the compound as shown in formula (2)：Lithium bromide：The mol ratio of phosphorus tribromide is 1: 1.8-
2.1∶0.5-0.8。
Ether solvent is absolute ether, propyl ether, isopropyl ether, butyl ether in described step (1), and methyl tertiary butyl ether(MTBE) is wherein
It is a kind of.
In described step (2), the compound as shown in formula (3)：Compound as shown in formula (6)：Mole of sodium hydride
Than for 1: 1: 1-1.5.
Medium, medium DMF, DMAC, DIPEA, triethylamine, the one of which of diethylamine are used in described step (2).
In described step (4), the mass ratio of intermediate and Pd/C as shown in formula (5) is 5%-10%.
Described step (4) uses medium, and medium is dimethylformamide, dimethyl acetamide (DMAC), diisopropyl
Ethamine, triethylamine, diethylamine, acetonitrile, the one of which of tetrahydrofuran.
Beneficial effect：
1st, step C obtains pentazocine chiral centre, traditional chiral resolution yield only has by simple method for synthesizing
40%, the method high income is up to 90%, and therefore, the total recovery for synthesizing pentazocine significantly improves, and for synthetic jets, he helps this step
The innovative point of pungent intermediate.
2nd, whole process route is succinct, and raw material is cheap and easily-available, and cost is low, easy to operate, and the pentazocine prepared is crucial
In m- 1,2,3,4,5,6- hexahydros-cis -6,11- dimethyl -2,6- methylene -3- benzo azocine -8- alcohol chiral purity it is high and
High income.
Figure of description
The H spectrograms of the compound of 2 Chinese style of Fig. 1 embodiments 1
Specific embodiment
Embodiment 1
1st, the preparation of compound 3
In 100mL reaction bulb, add compound 2 (1.86g, 19mmol) with 1.85g (15.3mmol) is anhydrous can power
Fourth mixed solution, 3.32g (38.2mmol) lithium bromide 40ml anhydrous ether solution, control temperature is in 40 degrees below zero to subzero
50 degree, 1.2ml (12.8mmol) phosphonium bromide is added dropwise, completion of dropwise addition, for control temperature at 0 DEG C, stirring reaction 2h, adding 2ml can power
Fourth, after addition water quenching is gone out, pentane is added, solution is extracted with pentane, organic phase water, saturated sodium bicarbonate solution, saturation
Sodium chloride solution is respectively washed one time, is dried with anhydrous magnesium sulfate, and reduced pressure boils off excess of solvent, obtains crude product, is slowly added
The diethyl ether solution (7ml) of subzero 40 ° of Zinc Bromide Anhydrous (3.75g, 16.7mmol), reaction system are warming up to 0 DEG C, stirring reaction
1.5h, then pentane and 50% sodium-chloride water solution be added into system, with pentane extract 3 times, organic phase saturation chlorine
Change sodium washing once, dried with anhydrous magnesium sulfate, decompression steams solvent, obtains 2.8g compounds 3, yield 90%
2nd, the preparation of compound 4
In 70ml DMF solution, compound 6 (3.0g, 20mmol) is added, after solution is cooled into 0 DEG C, is added
60%NaH (0.8g, 20mmol)) until after foam stopping, compound 3 (3.06g, 20mmol) being added in reaction system, slowly
Slowly room temperature is warming up to, be stirred overnight, after reaction terminates, add 2N NaOH (15ml) into reaction solution, be heated to 60 DEG C, stirring
2h is reacted, is cooled to room temperature, adds 3N sulfuric acid (60ml), this reaction solution is diluted with EA (60ml) to be layered, and organic phase is with 3N's
Sulfuric acid (20ml) extracts once, and aqueous phase merges, and is extracted with EA (20ml*1), adjusts pH value to 11 with 3N NaOH, uses methyl- tert
Butyl ether (30ml*2) extracts, and organic phase concentration, obtains compound 4 (4.0g, 91%)
3rd, the preparation of compound 5
In 500ml reaction bulb, polyphosphoric acids (10g), compound 4 (1.009g, 4.6mmol), 4- methoxyl groups are added
Phenylacetaldehyde (1.38g, 9.2mmol), by temperature control at 45 DEG C, in N2Under protection, 18h is reacted, reaction terminates, by reaction system
Cooling, add solid sodium carbonate and neutralize, extracted with chloroform (3*10ml), organic phase anhydrous sodium sulfate drying, in rotary evaporation
Solvent is spun off on instrument, crude product crosses pillar with ethyl acetate, petroleum ether, obtains compound 5 (1.3g, 84%)
4th, the preparation of the compound shown in formula 1
Compound 5 (10.1g, 30.3mmol) is dissolved in DMF (40mL), 2.5N HCl (250ml), adds 10%Pd-
C (1.18g), hydrogen is passed through, stirs 3h, HPLC detection reactions terminate.After being filtered to remove Pd-C, water (100mL), ammoniacal liquor are added
(20mL), extracted with ethyl acetate (100mL × 2), merge organic phase, the crude product after concentration crosses post purifying through MeOH/DCM systems
Obtain target compound 1 (6.1g, 92.6%).See accompanying drawing 1
Embodiment 2
1st, the preparation of compound 3
In 50mL reaction bulb, compound 2 (0.93g, 9.5mmol) and 0.93g (7.6mmol) anhydrous collidine are added
Mixed solution, 1.7g (19.1mmol) lithium bromide 20ml isopropyl ethereal solution, control temperature in 40 degrees below zero to subzero 50 degree,
0.6ml (6.4mmol) phosphonium bromide, completion of dropwise addition is added dropwise, control temperature adds 1ml collidines at 0 DEG C, stirring reaction 2h, adds
After water quenching is gone out, normal heptane is added, solution is extracted with normal heptane, and organic phase water, saturated sodium bicarbonate solution, saturated sodium-chloride are molten
Liquid is respectively washed one time, is dried with anhydrous magnesium sulfate, and reduced pressure boils off excess of solvent, obtains crude product, slowly adds subzero 40 °
The isopropyl ethereal solution (4ml) of Zinc Bromide Anhydrous (1.9g, 8.4mmol), reaction system are warming up to 0 DEG C, stirring reaction 1.5h, then
Normal heptane and 50% sodium-chloride water solution are added into system, are extracted 3 times with normal heptane, and organic phase washes one with saturated sodium-chloride
It is secondary, dried with anhydrous magnesium sulfate, decompression steams solvent, obtains 1.5g compounds 3, yield 97%.
2nd, the preparation of compound 4
In the solution of 35ml triethylamine, compound 6 (1.5g, 10mmol) is added, after solution is cooled into 0 DEG C, is added
Enter 60%NaH (0.4g, 10mmol)) until after foam stopping, compound 3 (1.53g, 10mmol) is added in reaction system,
Room temperature is slowly ramped to, is stirred overnight, after reaction terminates, 2N NaOH (8ml) is added into reaction solution, is heated to 60 DEG C, stirs
Reaction 2h is mixed, is cooled to room temperature, adds 3N sulfuric acid (30ml), this reaction solution is diluted with EA (30ml) to be layered, organic phase 3N
Sulfuric acid (10ml) extraction once, aqueous phase merges, and is extracted with EA (10ml*1), adjusts pH value to 11 with 3N NaOH, uses methyl
Tertbutyl ether (20ml*2) extracts, and organic phase concentration, obtains compound 4 (2.1g, 96%)
3rd, the preparation of compound 5
In 250ml reaction bulb, polyphosphoric acids (5g), compound 4 (0.5g, 2.3mmol), 4- methoxybenzene second are added
Aldehyde (0.7g, 4.6mmol), by temperature control at 45 DEG C, in N2Under protection, 18h is reacted, reaction terminates, reaction system is cooled down,
Add solid sodium carbonate to neutralize, extracted, organic phase anhydrous sodium sulfate drying, revolved on a rotary evaporator with chloroform (3*10ml)
Fall solvent, crude product crosses pillar with ethyl acetate, petroleum ether, obtains compound 5 (0.7g, 91%)
4th, the preparation of compound 1
Compound 5 (5.1g, 15.2mmol) is dissolved in DMAC (20mL), 2.5N HCl (130ml), adds 10%Pd-
C (0.6g), hydrogen is passed through, stirs 3h, HPLC detection reactions terminate.After being filtered to remove Pd-C, water (50mL), ammoniacal liquor are added
(10mL), extracted with ethyl acetate (50mL × 2), merge organic phase, the crude product after concentration crosses post purifying through MeOH/DCM systems
Obtain target compound 1 (3.1g, 94%).
Embodiment 3
1st, the preparation of compound 3
In 250mL reaction bulb, compound 2 (3.72g, 38mmol) and 3.7g (30.6mmol) anhydrous collidine are added
Mixed solution, 6.64g (76.4mmol) lithium bromide 80ml t-butyl methyl ether solution, control temperature in 40 degrees below zero to zero
It is lower 50 degree, 2.4ml (25.6mmol) phosphonium bromide is added dropwise, completion of dropwise addition, control temperature is at 0 DEG C, stirring reaction 2h, and adding 4ml can
Power fourth, after addition water quenching is gone out, pentane is added, solution is extracted with pentane, organic phase water, saturated sodium bicarbonate solution, is satisfied
Respectively wash with sodium chloride solution one time, dried with anhydrous magnesium sulfate, reduced pressure boils off excess of solvent, obtains crude product, slowly adds
Enter the t-butyl methyl ether solution (14ml) of subzero 40 ° of Zinc Bromide Anhydrous (7.5g, 33.4mmol), reaction system is warming up to 0
DEG C, stirring reaction 1.5h, then pentane and 50% sodium-chloride water solution be added into system, with pentane extract 3 times, it is organic
Mutually with saturated sodium-chloride washing once, dried with anhydrous magnesium sulfate, decompression steams solvent, obtains 5.6g compounds 3, yield 90%
2nd, the preparation of compound 4
In 150ml DIPEA solution, compound 6 (6.0g, 40mmol) is added, after solution is cooled into 0 DEG C, is added
Enter 60%NaH (1.6g, 40mmol)) until after foam stopping, compound 3 (6.12g, 40mmol) is added in reaction system,
Room temperature is slowly ramped to, is stirred overnight, after reaction terminates, 2N NaOH (30ml) is added into reaction solution, is heated to 60 DEG C, stirs
Reaction 2h is mixed, is cooled to room temperature, adds 3N sulfuric acid (120ml), this reaction solution is diluted with EA (120ml) to be layered, and organic phase is used
Once, aqueous phase merges, and is extracted with EA (40ml*1) for 3N sulfuric acid (40ml) extraction, adjusts pH value to 11 with 3N NaOH, uses first
Base tertbutyl ether (50ml*2) extracts, and organic phase concentration, obtains compound 4 (8.0g, 91%)
3rd, the preparation of compound 5
In 500ml reaction bulb, polyphosphoric acids (20g), compound 4 (2.018g, 9.2mmol), 4- methoxyl groups are added
Phenylacetaldehyde (2.76g, 18.4mmol), by temperature control at 45 DEG C, under N2 protections, 18h is reacted, reaction terminates, by reactant
System's cooling, add solid sodium carbonate and neutralize, extracted with chloroform (3*20ml), organic phase anhydrous sodium sulfate drying, steamed in rotation
Solvent is spun off on hair instrument, crude product crosses pillar with ethyl acetate, petroleum ether, obtains compound 5 (2.8g, 91%)
4th, the preparation of compound 1
Compound 5 (20.2g, 60.6mmol) is dissolved in THF (80mL), 2.5N HCl (500ml), adds 10%Pd-
C (2.4g), hydrogen is passed through, stirs 3h, HPLC detection reactions terminate.After being filtered to remove Pd-C, water (200mL), ammoniacal liquor are added
(40mL), extracted with ethyl acetate (200mL × 2), merge organic phase, the crude product after concentration crosses post purifying through MeOH/DCM systems
Obtain target compound 1 (12.5g, 93%).
Claims (7)
1. a kind of (-)-(2S, [2 ɑ, 6 ɑ, 11S])-1,2,3,4,5,6- hexahydros-cis-6,11- dimethyl as shown in Equation 1-
The preparation method of 2,6- methylene -3- benzo azocine -8- alcohol, it is characterised in that：Described synthetic method step is as follows：
(1) ring-opening reaction：Compound as shown in formula (2) is dissolved in collidine, and lithium bromide is dissolved in ether solvent, subzero
30-50 DEG C, bromination phosphorus reaction is added, obtains the compound as shown in formula (3)；
(2) coupling reaction：Compound as shown in formula (3) is reacted with the compound shown in formula (6) and sodium hydride, is obtained such as formula (4)
Shown compound；
(3) ring closure reaction：Compound as shown in formula (4) is in medium polyphosphoric acids, at 30-60 DEG C of temperature, with 4- methoxies
Ring-closure reaction occurs for base phenylacetaldehyde, obtains chiral centre * C, the compound as shown in formula (5)；
(4) hydrogenation：Intermediate as shown in formula (5) passes through in the presence of Pd/C, hydrogenates de- benzyl and obtains as shown in formula (1)
Target product.
2. preparation method according to claim 1, it is characterised in that：In described step (1), the change as shown in formula (2)
Compound：Lithium bromide：The mol ratio of phosphorus tribromide is 1：1.8-2.1:0.5-0.8.
3. preparation method according to claim 1 or 2, it is characterised in that：Ether solvent is anhydrous in described step (1)
Ether, propyl ether, isopropyl ether, butyl ether, the one of which of methyl tertiary butyl ether(MTBE).
4. preparation method according to claim 1, it is characterised in that：In described step (2), the change as shown in formula (3)
Compound：Compound as shown in formula (6)：The mol ratio of sodium hydride is 1:1：1-1.5.
5. the preparation method according to claim 1 or 4, it is characterised in that：Medium, medium are used in described step (2)
For DMF, DMAC, DIPEA, triethylamine, diethylamine one of which.
6. preparation method according to claim 1, it is characterised in that：In described step (4), as shown in formula (5) in
Mesosome and Pd/C mass ratio are 5%-10%.
7. the preparation method according to claim 1 or 6, it is characterised in that：Described step (4) uses medium, and medium is
Dimethylformamide, dimethyl acetamide (DMAC), diisopropylethylamine, triethylamine, diethylamine, acetonitrile, tetrahydrofuran its
Middle one kind.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114031505A (en) * | 2021-12-06 | 2022-02-11 | 和鼎（南京）医药技术有限公司 | Method for preparing pentazocine intermediate |
| WO2023232245A1 (en) * | 2022-06-01 | 2023-12-07 | Symrise Ag | Fragrances with cyclopropyl structure |
-
2017
- 2017-10-13 CN CN201710956550.4A patent/CN107698507A/en active Pending
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| Title |
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| PAUL R.ALLEN等: "Synthesis of the bis-spiroacetal moiety of the polyether antibiotic CP44,161", 《JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1》 * |
| PAVEL A. DONETS等: "Diaminophosphine Oxide Ligand Enabled Asymmetric Nickel-Catalyzed Hydrocarbamoylations of Alkenes", 《J. AM. CHEM. SOC.》 * |
| TETSUJI KAMETAN等: "Studies on the Synthesesof Heterocyclic Compounds. Part DCXXXVI.An Alternative Synthesis of Pentazocine", 《CANADIAN JOURNAL OF CHEMISTRY》 * |
| WILLIAM S.JOHNSON等: "The Fluorine Atom as a Cation-Stabilizing Auxiliary in Biomimetic polyene cyclizations.4. Total synthesis of dl-β-amyrin.", 《J. AM. CHEM.SOC.》 * |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114031505A (en) * | 2021-12-06 | 2022-02-11 | 和鼎（南京）医药技术有限公司 | Method for preparing pentazocine intermediate |
| CN114031505B (en) * | 2021-12-06 | 2024-02-02 | 和鼎（南京）医药技术有限公司 | Method for preparing pentazocine intermediate |
| WO2023232245A1 (en) * | 2022-06-01 | 2023-12-07 | Symrise Ag | Fragrances with cyclopropyl structure |
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Application publication date: 20180216 |