CN107693776A - 用于治疗无效性红细胞生成的方法和组合物 - Google Patents

用于治疗无效性红细胞生成的方法和组合物 Download PDF

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Publication number
CN107693776A
CN107693776A CN201711069457.8A CN201711069457A CN107693776A CN 107693776 A CN107693776 A CN 107693776A CN 201711069457 A CN201711069457 A CN 201711069457A CN 107693776 A CN107693776 A CN 107693776A
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CN
China
Prior art keywords
actriib
gdf trap
seq
polypeptide
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN201711069457.8A
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English (en)
Chinese (zh)
Inventor
J.斯拉
R.S.皮萨尔
R.库马
N.V.S.R.苏拉加尼
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Acceleron Pharma Inc
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Acceleron Pharma Inc
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Application filed by Acceleron Pharma Inc filed Critical Acceleron Pharma Inc
Publication of CN107693776A publication Critical patent/CN107693776A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/1103—Receptor protein serine/threonine kinase (2.7.11.30)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201711069457.8A 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物 Pending CN107693776A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161547932P 2011-10-17 2011-10-17
US61/547932 2011-10-17
CN201280061672.2A CN103987403B (zh) 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201280061672.2A Division CN103987403B (zh) 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物

Publications (1)

Publication Number Publication Date
CN107693776A true CN107693776A (zh) 2018-02-16

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Family Applications (3)

Application Number Title Priority Date Filing Date
CN201711069457.8A Pending CN107693776A (zh) 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物
CN201711069431.3A Pending CN107837390A (zh) 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物
CN201280061672.2A Active CN103987403B (zh) 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物

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Application Number Title Priority Date Filing Date
CN201711069431.3A Pending CN107837390A (zh) 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物
CN201280061672.2A Active CN103987403B (zh) 2011-10-17 2012-10-17 用于治疗无效性红细胞生成的方法和组合物

Country Status (13)

Country Link
US (4) US20130243743A1 (cg-RX-API-DMAC7.html)
EP (3) EP3875104B1 (cg-RX-API-DMAC7.html)
JP (4) JP6092883B2 (cg-RX-API-DMAC7.html)
KR (4) KR102079482B1 (cg-RX-API-DMAC7.html)
CN (3) CN107693776A (cg-RX-API-DMAC7.html)
AU (4) AU2012326207B2 (cg-RX-API-DMAC7.html)
BR (3) BR122019023174B1 (cg-RX-API-DMAC7.html)
CA (1) CA2852683A1 (cg-RX-API-DMAC7.html)
DK (2) DK3520805T3 (cg-RX-API-DMAC7.html)
EA (2) EA202090053A3 (cg-RX-API-DMAC7.html)
ES (3) ES2741477T3 (cg-RX-API-DMAC7.html)
HK (2) HK1250341A1 (cg-RX-API-DMAC7.html)
WO (1) WO2013059347A1 (cg-RX-API-DMAC7.html)

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Also Published As

Publication number Publication date
CN103987403B (zh) 2017-12-01
HK1252940A1 (zh) 2019-06-06
JP6796626B2 (ja) 2020-12-09
JP6092883B2 (ja) 2017-03-08
US20170137791A1 (en) 2017-05-18
KR20140084211A (ko) 2014-07-04
KR20220075438A (ko) 2022-06-08
BR112014009528A2 (pt) 2017-05-09
EA034563B1 (ru) 2020-02-20
BR122019023174B1 (pt) 2021-02-23
US20210207107A1 (en) 2021-07-08
AU2018247262B2 (en) 2020-12-24
JP2017101060A (ja) 2017-06-08
JP6383821B2 (ja) 2018-08-29
EP2797620A4 (en) 2015-05-20
US20170327800A1 (en) 2017-11-16
AU2017201580A1 (en) 2017-03-30
DK3875104T3 (da) 2025-02-03
KR20200019261A (ko) 2020-02-21
EP3875104A1 (en) 2021-09-08
JP2020186277A (ja) 2020-11-19
EP3520805A1 (en) 2019-08-07
BR122019023166B1 (pt) 2021-02-23
AU2017201580B2 (en) 2018-07-12
HK1203413A1 (en) 2015-10-30
AU2012326207A1 (en) 2014-05-15
AU2018247262A1 (en) 2018-11-01
CN103987403A (zh) 2014-08-13
BR112014009528B1 (pt) 2020-12-29
WO2013059347A1 (en) 2013-04-25
ES3010483T3 (en) 2025-04-03
EP3875104B1 (en) 2025-01-22
BR112014009528A8 (pt) 2019-12-10
EA201490809A1 (ru) 2014-09-30
JP2014530253A (ja) 2014-11-17
EP2797620B1 (en) 2019-04-24
KR20190105113A (ko) 2019-09-11
EA202090053A3 (ru) 2020-06-30
DK3520805T3 (da) 2021-04-19
EP2797620A1 (en) 2014-11-05
CA2852683A1 (en) 2013-04-25
US20130243743A1 (en) 2013-09-19
ES2869168T3 (es) 2021-10-25
ES2741477T3 (es) 2020-02-11
HK1250341A1 (zh) 2018-12-14
EP3520805B1 (en) 2021-03-10
CN107837390A (zh) 2018-03-27
AU2012326207B2 (en) 2016-12-15
JP2018165287A (ja) 2018-10-25
AU2020286229A1 (en) 2021-01-07
EA202090053A2 (ru) 2020-04-30
KR102079482B1 (ko) 2020-02-19

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