CN107692221A - A kind of nutritious supplementary pharmaceutical for being used to before corrective surgery drink - Google Patents

A kind of nutritious supplementary pharmaceutical for being used to before corrective surgery drink Download PDF

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Publication number
CN107692221A
CN107692221A CN201710965122.8A CN201710965122A CN107692221A CN 107692221 A CN107692221 A CN 107692221A CN 201710965122 A CN201710965122 A CN 201710965122A CN 107692221 A CN107692221 A CN 107692221A
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CN
China
Prior art keywords
nutritious supplementary
supplementary pharmaceutical
glucose
replenishers
acidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710965122.8A
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Chinese (zh)
Inventor
胡昊宇
范师振
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Individual
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Individual
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Priority to CN201710965122.8A priority Critical patent/CN107692221A/en
Publication of CN107692221A publication Critical patent/CN107692221A/en
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16Inorganic salts, minerals or trace elements
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Non-Alcoholic Beverages (AREA)

Abstract

The present invention provides a kind of nutritious supplementary pharmaceutical for being used to before corrective surgery drink, particularly it is used for the preoperative nutritious supplementary pharmaceutical drunk of general anesthesia operation patient, it is made up of water, sodium chloride, potassium chloride, glucose and acidic ph modifier, it is characterised in that by weight, sodium chloride:The proportioning of potassium chloride is (4~5):1, glucose:The proportioning of potassium chloride is (60~210):1, and KCE content is 0.2~0.4g/L in replenishers, and the pH value of acidic ph modifier regulation replenishers is 4.0~7.0.Belong to dietetic food technical field.

Description

A kind of nutritious supplementary pharmaceutical for being used to before corrective surgery drink
【Technical field】
The present invention provides a kind of nutritious supplementary pharmaceutical for being used to before corrective surgery drink, particularly for general anesthesia operation patient's art Before the nutritious supplementary pharmaceutical drunk.Belong to dietetic food technical field.
【Background technology】
Medical profession traditional view thinks, healthy babies (<2 years old), children (2~16 years old) and adult are receiving what is chosen date for operation The fasting liquid of 2 hours or longer time before general anesthesia, local anaesthesia or procedural sedation and continuous analgesia.But after prohibiting water, suffer from Person's hydropenia, electrolyte and carbohydrate are lost and cannot supplemented in body fluid, and body acid-base buffer system changes, and exempts from Epidemic disease power declines;Mucosa is caused to decline in addition, oral cavity and respiratory mucosa are dried, patient feels mouth parched and tongue scorched, influences The postoperative mood of patient, is unfavorable for post-operative recovery.In recent years, Medical Technologist gradually starts to think, operation consent two hours, Ke Yirang Patient drinks some clear beverages in right amount, in favor of patient's post-operative recovery.
But clinically lack a kind of suitable battalion of the standardization dedicated for the preoperative reference of general anesthesia operation patient at present Support replenishers.If the patient that leaves voluntarily keeps the skin wet or beverage, formula and dosage can not be controlled, and be unfavorable for controlling hand Risk during art, it is unfavorable for post-operative recovery, also easily triggers malpractice and doctor-patient dispute.
CN103006694A discloses a kind of fluid infusion salt formula for treating various animal hypertonic dehydrations and preparation method thereof, its group As sodium chloride 5.1g, potassium chloride 0.2g, glucose 0.4g and sodium lactate 1.9g.0.77g is taken to be dissolved in 100ml distilled water during use In, freely drink.The product is hypotonic solution, and fluid infusion is carried out for animal hypertonic dehydration state.
CN103380900A discloses a kind of flavoring type oral rehydration salt powder, by sodium chloride 0.65, potassium chloride 0.375, Chinese holly Rafter acid sodium 0.725 and DEXTROSE ANHYDROUS 3.375 are formed, and taste is added by different modes on the basis of former ORS Different essence, the flavoring type oral rehydration salt powder of different taste is made.
CN103610692A discloses a kind of preparation method of low-permeability oral rehydration salt, and described low-permeability oral rehydration salt is by chlorine Change sodium 0.65, potassium chloride 0.375, sodium citrate 0.725 and DEXTROSE ANHYDROUS 3.375 to form.
ORS disclosed above, have plenty of solid forms and prepared, it is necessary to weigh before use, it is difficult to control electrolyte Concentration and dosage;Some mouthfeels are bad, it is also necessary to add essence school taste;And these fluid infusion salt are not for before general anesthesia operation The special drink of patient.In addition, often deposited in these product preparation process without aseptic filtration or high-temperature sterilization, security In certain risk.
【The content of the invention】
For these technological deficiencies existing for prior art, the present invention provides a kind of nutrition for being used to before corrective surgery drink Replenishers, particularly for the preoperative nutritious supplementary pharmaceutical drunk of general anesthesia operation patient.
Technical solution of the present invention is as follows:
The invention provides a kind of nutritious supplementary pharmaceutical for being used to before corrective surgery drink, by water, sodium chloride, potassium chloride, Portugal Grape sugar and acidic ph modifier composition, it is characterised in that by weight, sodium chloride:The proportioning of potassium chloride is (4~5):1, Portugal Grape sugar:The proportioning of potassium chloride is (60~210):1, and KCE content is 0.2~0.4g/L in replenishers, and acid pH is adjusted The pH value of agent regulation replenishers is 4.0~7.0.
Nutritious supplementary pharmaceutical described above, each component content are:Sodium chloride 1.12g/L, potassium chloride 0.237g/L, glucose 15~50g/L, the pH value of acidic ph modifier regulation replenishers is 4.0~7.0.
Preferably, nutritious supplementary pharmaceutical described above, is micro- sugared nutritious supplementary pharmaceutical, and each component content is:Sodium chloride 1.12g/L, potassium chloride 0.237g/L, glucose 15g/L, the pH value of acidic ph modifier regulation replenishers is 4.0~7.0.
Preferably, nutritious supplementary pharmaceutical described above, is low-sugar nutritional replenishers, and each component content is:Sodium chloride 1.12g/L, potassium chloride 0.237g/L, 30~50g/L of glucose, the pH value of acidic ph modifier regulation replenishers for 4.0~ 7.0。
It is highly preferred that nutritious supplementary pharmaceutical described above, each component content are:Sodium chloride 1.12g/L, potassium chloride 0.237g/L, glucose 30g/L, the pH value of acidic ph modifier regulation replenishers is 4.0~7.0.
It is highly preferred that nutritious supplementary pharmaceutical described above, each component content are:Sodium chloride 1.12g/L, potassium chloride 0.237g/L, glucose 50g/L, the pH value of acidic ph modifier regulation replenishers is 4.0~7.0.
Preferably, nutritious supplementary pharmaceutical described above, the acidic ph modifier are organic acid or inorganic acid, such as salt Acid, citric acid, arginine or acetic acid etc..
Preferably, nutritious supplementary pharmaceutical described above, by micropore of the solution that each component is mixed to get through 0.45~0.6um Filter filters, through 110~130 DEG C of autoclavings after packing.
Preferably, nutritious supplementary pharmaceutical described above, it is divided in soft bag, is no more than 200ml per packed amount.
Preferably, nutritious supplementary pharmaceutical described above, it is used as the preoperative nutritious supplementary pharmaceutical drunk of general anesthesia operation patient.
Present invention nutritious supplementary pharmaceutical described above, after component is mixed and dissolved, solution regulation pH to 4.0 to 7.0, use Millipore filter filters, and is dispensed into suitable container (container preferentially selects flexible package), and every loading amount is below 200ml, sealing, Autoclave sterilization.
Preferably, above-mentioned nutritious supplementary pharmaceutical can be used for the operation patients of high blood glucose
The bubble-free ion aquatic products of the present invention are by obtained from test repeatedly based on physiology.Compared to existing Technology, the beneficial effect of nutritious supplementary pharmaceutical of the invention is at least:Traditional anesthesia and operation consent will shift to an earlier date the taboo of fasting in 8 hours Water, current medical technically allow to drink clear beverage before anaesthetizing and perform the operation 2 hours on a small quantity, but clinically lack at present a kind of special Suitable nutritious supplementary pharmaceutical for the standardization of the preoperative reference of general anesthesia operation patient.If the patient that leaves voluntarily keep the skin wet or Beverage, formula and dosage can not be controlled, and are unfavorable for controlling the risk in surgical procedure, are unfavorable for post-operative recovery, also hold Easily trigger malpractice and doctor-patient dispute.The present inventor is for these technical problems present in existing medical technology, it is proposed that A kind of solution of standardization so that anesthesia and operation consent drinking water meet medical physiology requirement, have more safety and More preferable patient perceptions.The present invention also is adapted for carrying out industrial automation production.
【Embodiment】
Following embodiments are for a better understanding of the present invention, and to be understood not to the limit to the scope of the present invention System.
Embodiment 1:
Recipe quantity food grade sodium chloride, potassium chloride and glucose are dissolved in drinking water, obtained containing 1.12g/L, chlorine Change potassium 0.237g/L, glucose 15g/L solution, regulation pH to 4.0 to 7.0 is adjusted with watery hydrochloric acid.Filtered with 0.45um micropore Device filters, and is dispensed into soft bag, and every loading amount is 200ml, sealing, 121 degrees Celsius of autoclavings.
Embodiment 2:
Recipe quantity food grade sodium chloride, potassium chloride and glucose are dissolved in drinking water, obtained containing 1.12g/L, chlorine Change potassium 0.237g/L, glucose 30g/L solution, regulation pH to 4.0 to 7.0 is adjusted with citric acid.With 0.6um millipore filter Filtering, is dispensed into soft bag, and every loading amount is 100ml, sealing, 115 degrees Celsius of autoclavings.
Embodiment 3:
Recipe quantity medicine grade sodium chloride, potassium chloride and glucose are dissolved in drinking water, obtained containing 1.12g/L, chlorine Change potassium 0.237g/L, glucose 50g/L solution, with vinegar acid for adjusting pH to 4.0 to 7.0.Filtered with 0.6um millipore filter, It is dispensed into plastic bottle, every loading amount is 50ml, sealing, 100 degrees Celsius of flowing steam sterilizations.
Embodiment 4:
Recipe quantity food grade sodium chloride, potassium chloride and glucose are dissolved in purified water, obtained containing 1.12g/L, chlorine Change potassium 0.237g/L, glucose 40g/L solution, with arginine acid regulation regulation pH to 4.0 to 7.0.With 0.45um micropore Filter filters, and is dispensed into soft bag, and every loading amount is 150ml, sealing, 121 degrees Celsius of autoclavings.
Product of the present invention is mainly used in the preoperative use of general anesthesia operation patient.In order to verify the feasibility of this product Clinical practice and Applicability, tests below is carried out:
Choose 80 health volunteers (65~75KG of body weight, 25~35 years old age male) and be divided into 16 groups, give within first 48 hours Standard diet is given, then fasting 8 hours, then every one group of five people, every group of volunteer drink the clear beverage in following form 200ml, control group of not drinking water completely is separately set, only drink pure water control group.Each group volunteer's mouthfeel is investigated after drinking immediately;After Oral mucosa secretion viscosity is checked, and investigates the degree of dry within six hours.As a result it is as follows:
Wherein, test article one, two and five, by compatibility is formed in table, drink is made by the method for embodiment 1.
Above-mentioned result of the test shows, the drink of the ion concentration of the present invention best results in impression and mucous membrane viscosity, fits In as the preoperative special drink drunk of general anesthesia operation patient.

Claims (10)

1. a kind of nutritious supplementary pharmaceutical for being used to before corrective surgery drink, is adjusted by water, sodium chloride, potassium chloride, glucose and acid pH Save agent composition, it is characterised in that by weight, sodium chloride:The proportioning of potassium chloride is (4~5):1, glucose:Potassium chloride is matched somebody with somebody Than for (60~210):1, and KCE content is 0.2~0.4g/L in replenishers, acidic ph modifier regulation replenishers PH value is 4.0~7.0.
2. nutritious supplementary pharmaceutical according to claim 1, it is characterised in that each component content is:Sodium chloride 1.12g/L, chlorination Potassium 0.237g/L, 15~50g/L of glucose, the pH value of acidic ph modifier regulation replenishers is 4.0~7.0.
3. nutritious supplementary pharmaceutical according to claim 1, it is characterised in that each component content is:Sodium chloride 1.12g/L, chlorination Potassium 0.237g/L, glucose 15g/L, the pH value of acidic ph modifier regulation replenishers is 4.0~7.0.
4. nutritious supplementary pharmaceutical according to claim 1, it is characterised in that each component content is:Sodium chloride 1.12g/L, chlorination Potassium 0.237g/L, 30~50g/L of glucose, the pH value of acidic ph modifier regulation replenishers is 4.0~7.0.
5. nutritious supplementary pharmaceutical according to claim 1, it is characterised in that each component content is:Sodium chloride 1.12g/L, chlorination Potassium 0.237g/L, glucose 30g/L, the pH value of acidic ph modifier regulation replenishers is 4.0~7.0.
6. nutritious supplementary pharmaceutical according to claim 1, it is characterised in that each component content is:Sodium chloride 1.12g/L, chlorination Potassium 0.237g/L, glucose 50g/L, the pH value of acidic ph modifier regulation replenishers is 4.0~7.0.
7. according to the nutritious supplementary pharmaceutical described in claim 1-6, it is characterised in that the acidic ph modifier is organic acid or nothing Machine acid, preferably hydrochloric acid, citric acid, arginine or acetic acid.
8. according to the nutritious supplementary pharmaceutical described in claim 1-7, it is characterised in that the solution for being mixed to get each component is through 0.45 ~0.6um millipore filter filtering, through 110~130 DEG C of autoclavings after packing.
9. according to the nutritious supplementary pharmaceutical described in claim 1-8, it is divided in soft bag, is no more than 200ml per packed amount.
10. the nutritious supplementary pharmaceutical described in claim 1-9, it is used as the preoperative nutritious supplementary pharmaceutical drunk of general anesthesia operation patient.
CN201710965122.8A 2017-10-17 2017-10-17 A kind of nutritious supplementary pharmaceutical for being used to before corrective surgery drink Pending CN107692221A (en)

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CN201710965122.8A CN107692221A (en) 2017-10-17 2017-10-17 A kind of nutritious supplementary pharmaceutical for being used to before corrective surgery drink

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Application Number Priority Date Filing Date Title
CN201710965122.8A CN107692221A (en) 2017-10-17 2017-10-17 A kind of nutritious supplementary pharmaceutical for being used to before corrective surgery drink

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109567167A (en) * 2018-12-25 2019-04-05 梁力中 A kind of alimentation composition and its preparation method and application containing Pseudobulbus Bletillae (Rhizoma Bletillae) extract suitable for pre-operative patients
US20190374569A1 (en) * 2018-06-12 2019-12-12 Richard Laver Intact pea protein-based nutrient composition
US10806169B2 (en) 2018-05-15 2020-10-20 Kate Farms, Inc. Hydrolyzed pea protein-based nutrient composition

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002125639A (en) * 2000-10-25 2002-05-08 Otsuka Pharmaceut Factory Inc Beverage or jelly for supplying water electrolyte
CN103479664A (en) * 2013-09-24 2014-01-01 辽宁亿灵科创生物医药科技有限公司 Liquid oral rehydration salt
CN103610692B (en) * 2013-12-05 2015-11-18 厦门恩成制药有限公司 A kind of preparation method of low-permeability oral rehydration salt
CN105795481A (en) * 2016-03-24 2016-07-27 广州军区广州总医院 Special nutritional supplement agent for preoperative patients

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002125639A (en) * 2000-10-25 2002-05-08 Otsuka Pharmaceut Factory Inc Beverage or jelly for supplying water electrolyte
CN103479664A (en) * 2013-09-24 2014-01-01 辽宁亿灵科创生物医药科技有限公司 Liquid oral rehydration salt
CN103610692B (en) * 2013-12-05 2015-11-18 厦门恩成制药有限公司 A kind of preparation method of low-permeability oral rehydration salt
CN105795481A (en) * 2016-03-24 2016-07-27 广州军区广州总医院 Special nutritional supplement agent for preoperative patients

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10806169B2 (en) 2018-05-15 2020-10-20 Kate Farms, Inc. Hydrolyzed pea protein-based nutrient composition
US20190374569A1 (en) * 2018-06-12 2019-12-12 Richard Laver Intact pea protein-based nutrient composition
CN109567167A (en) * 2018-12-25 2019-04-05 梁力中 A kind of alimentation composition and its preparation method and application containing Pseudobulbus Bletillae (Rhizoma Bletillae) extract suitable for pre-operative patients

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Application publication date: 20180216

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