CN107683431B - 用于使结构化照明成像系统中的样品台稳定的系统和方法 - Google Patents

用于使结构化照明成像系统中的样品台稳定的系统和方法 Download PDF

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Publication number
CN107683431B
CN107683431B CN201680032271.2A CN201680032271A CN107683431B CN 107683431 B CN107683431 B CN 107683431B CN 201680032271 A CN201680032271 A CN 201680032271A CN 107683431 B CN107683431 B CN 107683431B
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sample
imaging
sample stage
illumination light
pinhole
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English (en)
Chinese (zh)
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CN107683431A (zh
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A·甘德森
P·博伊斯克腾
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Life Technologies Corp
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Life Technologies Corp
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    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/26—Stages; Adjusting means therefor
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036—Scanning details, e.g. scanning stages
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02K—DYNAMO-ELECTRIC MACHINES
    • H02K33/00—Motors with reciprocating, oscillating or vibrating magnet, armature or coil system

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  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Power Engineering (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
CN201680032271.2A 2015-06-02 2016-05-10 用于使结构化照明成像系统中的样品台稳定的系统和方法 Active CN107683431B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562169683P 2015-06-02 2015-06-02
US62/169,683 2015-06-02
PCT/US2016/031572 WO2016195928A1 (en) 2015-06-02 2016-05-10 Systems and methods for stabilizing a sample stage in a structured illumination imaging system

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CN107683431A CN107683431A (zh) 2018-02-09
CN107683431B true CN107683431B (zh) 2021-01-01

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US (1) US10921574B2 (enExample)
EP (1) EP3304163B1 (enExample)
JP (1) JP6712429B2 (enExample)
CN (1) CN107683431B (enExample)
WO (1) WO2016195928A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10444486B2 (en) * 2017-09-04 2019-10-15 Microscopes International, Llc Systems and methods for detection of blank fields in digital microscopes
WO2022020729A2 (en) * 2020-07-23 2022-01-27 Life Technologies Corporation Systems and methods for biological analysis
TWI831078B (zh) * 2020-12-11 2024-02-01 國立中央大學 應用影像還原的光學系統及光學影像處理方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01302195A (ja) * 1988-05-31 1989-12-06 Canon Inc 位置決め装置
JP2002014043A (ja) * 2000-06-28 2002-01-18 Tokyo Instruments Inc 顕微鏡用マルチカラー分析装置及び顕微鏡を用いたマルチカラー分析方法
JP4007854B2 (ja) * 2002-05-23 2007-11-14 オリンパス株式会社 サンプリングクロック発生装置
JP2008136318A (ja) * 2006-11-29 2008-06-12 Olympus Corp 超音波モータ及び顕微鏡ステージ
JP2013167654A (ja) * 2010-05-31 2013-08-29 Univ Of Tokyo 共焦点顕微鏡画像システム
US9041791B2 (en) * 2011-02-01 2015-05-26 Roche Diagnostics Hematology, Inc. Fast auto-focus in imaging
WO2013126999A1 (en) * 2012-03-02 2013-09-06 Huron Technologies International Inc. Scanner with increased dynamic range
KR101490260B1 (ko) * 2013-07-09 2015-02-06 한국과학기술연구원 단일 진동자를 이용한 다방향 진동 발생 장치 및 진동 생성 방법

Also Published As

Publication number Publication date
JP2018522268A (ja) 2018-08-09
CN107683431A (zh) 2018-02-09
EP3304163B1 (en) 2020-05-06
US10921574B2 (en) 2021-02-16
JP6712429B2 (ja) 2020-06-24
WO2016195928A1 (en) 2016-12-08
EP3304163A1 (en) 2018-04-11
US20180157023A1 (en) 2018-06-07

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