CN107669915A - Treat sophora bud oral liquid of cardiovascular and cerebrovascular diseases and preparation method thereof - Google Patents

Abstract

The present invention provides a kind of sophora bud oral liquid for treating cardiovascular and cerebrovascular diseases, and bulk drug is made up of following component：The sophora bud, the red sage root, Radix Angelicae Sinensis, Radix Codonopsis, the fleece-flower root, the Radix Astragali, ginseng, the radix paeoniae rubrathe, pseudo-ginseng, rhizoma Gastrodiae, the fruit of Chinese wolfberry, safflower, Chinese cassia tree, cortex acanthopanacis, cassia seed, day lily, reticulate millettia, hairyvein agrimony, gynostemma pentaphylla, folium cortex eucommiae, honeysuckle, cultivated land, ground bettle, earthworm, bluish dogbane, radix glycyrrhizae, the oral liquid are adapted to：Hypertension, hyperlipemic patients, cardiac, cerebral apoplexy sequela patient etc..

Description

Treat sophora bud oral liquid of cardiovascular and cerebrovascular diseases and preparation method thereof

Technical field

The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of sophora bud oral liquid for treating cardiovascular and cerebrovascular diseases and its preparation Method.

Background technology

Due to the horizontal continuous improvement of modern society's life, physical demands is increasingly reduced again, and the fat deposition in human body is bright Aobvious increase, overweight people troop expand increasingly, and data are shown：Germany population 61,400,000, super severe one account for more than 50%, Mexico The people of swelling fertilizer accounts for 44%, and Switzerland, Australia are all more than 40%, and Chinese 70,000,000 people are fat, and 200,000,000 people are overweight；Obesity is not only society Problem, and be also very big medical problem, obesity is hypertension, high fat of blood, the hyperglycaemia seed of trouble.

People's trembled with fear, the wet, stasis of blood, acid are that cardiovascular and cerebrovascular disease forms the seed of trouble；After cold, the wet invasion and attack body vital organs of the human body, cause body Empty, immunity degradation, cold, wet development cause cyclic metabolism obstacle, slow blood flow, flow velocity slowly causes pressure into toxin, rubbish Increase, the lipid material in blood can precipitate, and be attached on vascular wall, and formation blood vessel is thicker, luminal stenosis, adds A large amount of arteriosclerosis plaques and lipid deposition, cause angiemphraxis, and supply of blood flow interrupts, and endovascular toxicant is not easy to arrange Go out；If blood viscosity is too high, resistance increase, at this moment if vasopasm, then hypertension can be produced suddenly, if in blood Lipid material be deposited in angiocarpy, then cause coronary heart disease, be deposited in the cerebrovascular, then cause cerebrovascular disease.

The treatment method of traditional heart and brain disease is mainly decompression, lipid-loweringing, support, bridging, and therapeutic effect is not ideal, therefore, It is necessary to develop a kind of sophora bud oral liquid for treating cardiovascular and cerebrovascular diseases.

The content of the invention

An object of the present invention is to provide a kind of sophora bud oral liquid for treating cardiovascular and cerebrovascular diseases, the oral liquid energy of the sophora bud Enough treat a variety of cardiovascular and cerebrovascular diseases.

The second object of the present invention is the preparation method for providing above-mentioned sophora bud oral liquid.

The sophora bud oral liquid of present invention treatment cardiovascular and cerebrovascular diseases, in terms of weight fraction, is made up of the following raw material：With weight point Number meter, bulk drug are made up of following component：

Sophora bud 350-450 parts, red sage root 250-350 parts, Radix Angelicae Sinensis 200-300 parts, Radix Codonopsis 200-300 parts, fleece-flower root 200-300 parts, Radix Astragali 150-250 parts, ginseng 200-300 parts, radix paeoniae rubrathe 150-250 parts, pseudo-ginseng 200-300 parts, rhizoma Gastrodiae 200-300 parts, the fruit of Chinese wolfberry 200-300 parts, safflower 100-200 parts, Chinese cassia tree 200-300 parts, cortex acanthopanacis 250-350 parts, cassia seed 200-300 parts, day lily 350-450 parts, reticulate millettia 300-400 parts, hairyvein agrimony 250-350 parts, gynostemma pentaphylla 250-350 parts, folium cortex eucommiae 250-350 parts, gold Honeysuckle flower 250-350 parts, cultivated land 250-350 parts, ground bettle 200-300 parts, earthworm 150-250 parts, bluish dogbane 250-350 parts are sweet Careless 150-250 parts.

The preferred 360-440 parts of the wherein described sophora bud, the preferred 270-340 parts of the red sage root, the preferred 210-290 parts of Radix Angelicae Sinensis, Radix Codonopsis It is preferred that 220-290 parts.

The preferred 210-280 parts of the wherein described fleece-flower root, the preferred 160-240 parts of the Radix Astragali, the preferred 220-280 parts of ginseng are red The preferred 160-240 parts of Chinese herbaceous peony.

The preferred 230-280 parts of wherein described pseudo-ginseng, the preferred 230-270 parts of rhizoma Gastrodiae, the preferred 220-270 parts of the fruit of Chinese wolfberry.

The preferred 130-170 parts of wherein described safflower, the preferred 220-270 parts of Chinese cassia tree, the preferred 280-320 parts of cortex acanthopanacis, certainly The preferred 230-280 parts of pine torch.

The preferred 360-430 parts of wherein described day lily, the preferred 320-390 parts of reticulate millettia, the preferred 270-330 of hairyvein agrimony Part, the preferred 270-340 parts of gynostemma pentaphylla.

The preferred 270-320 parts of wherein described folium cortex eucommiae, the preferred 280-320 parts of honeysuckle, the preferred 280-320 parts of cultivated land, The preferred 230-270 parts of ground bettle.

Wherein described preferred 170-230 parts of earthworm, the preferred 280-320 parts of bluish dogbane, the preferred 180-210 parts of radix glycyrrhizae.

The present invention optimal technical solution be：A kind of herbal wine, in terms of weight fraction, bulk drug is by following component system Into：500 parts of the sophora bud, 300 parts of the red sage root, 250 parts of Radix Angelicae Sinensis, 250 parts of Radix Codonopsis, 250 parts of the fleece-flower root, 200 parts of the Radix Astragali, 250 parts of ginseng are red 200 parts of Chinese herbaceous peony, 250 parts of pseudo-ginseng, 250 parts of rhizoma Gastrodiae, 250 parts of the fruit of Chinese wolfberry, 150 parts of safflower, 250 parts of Chinese cassia tree, 300 parts of cortex acanthopanacis, Cassia 250 parts of son, 400 parts of day lily, 350 parts of reticulate millettia, 300 parts of hairyvein agrimony, 300 parts of gynostemma pentaphylla, 300 parts of folium cortex eucommiae, honeysuckle 300 Part, 300 parts of cultivated land, 250 parts of ground bettle, 200 parts of earthworm, 300 parts of bluish dogbane, 200 parts of radix glycyrrhizae.

The preparation method of the sophora bud oral liquid of present invention treatment cardiovascular and cerebrovascular diseases in turn includes the following steps：

（1）The raw material weighed up is put into decocting container, adds water, boiled rear slow fire is decocted 20-40 minutes, and maintenance boiling water is Can；Wherein the weight ratio of Chinese medicine material and water is 1:（3-5）；

（2）By well-done medical filtration；It is filling.

The sophora bud oral liquid instructions of taking of present invention treatment cardiovascular and cerebrovascular diseases is as follows：Warmly take 3 times a day, each 50- 100ml。

The sophora bud oral liquid of present invention treatment cardiovascular and cerebrovascular diseases is adapted to following condition subject：Hypertension, high fat of blood and mistake Dormancy patient, cardiac, cerebral apoplexy sequela patient etc..

Embodiment

Embodiment of the present invention is described in detail below in conjunction with example, but those skilled in the art will manage Solution, the following example is merely to illustrate the present invention, and should not be taken as limiting the scope of the invention.

Table 1 is raw material and quality used in embodiment 1-6, comparative example 1-2, and comparative example 1 is on the basis of embodiment 1 Cortex acanthopanacis is eliminated, comparative example 2 is to eliminate hairyvein agrimony on the basis of embodiment 1.

Table 1, unit are gram

。

Each embodiment, the preparation method of comparative example sophora bud oral liquid include：

（1）The raw material weighed up is put into decocting container, adds water, boiled rear slow fire is decocted 30 minutes, maintains boiling water；Its The weight ratio of middle Chinese medicine material and water is 1:4；

（2）By well-done medical filtration；It is filling.

Each embodiment, the application experiment method of comparative example sophora bud oral liquid are as follows.

A groups:

Coronary Heart Disease Patients 80 are treated, are divided into 8 groups, every group of 10 people, every group of patient takes embodiment 1-6, comparative example 1-2 mouth respectively Liquid is taken, 3 times a day, each 50mL, 40 minutes warm boiled waters before meals, 30 days are 1 course for the treatment of, take 6 courses for the treatment of.

B groups：Thrombolysis contrasts, and patient 90, is divided into 9 groups, every group of 10 people, every group is taken embodiment 1-6, comparative example 1- respectively 2 oral liquid, one group is that western drug is treated（Control group）, 3 times a day, each 50mL, 40 minutes warm boiled waters before meals, 30 days For 1 course for the treatment of, 2 courses for the treatment of are taken, two groups of patients compare at age, sex, thrombosis position, the course of disease, clinical manifestation etc. Compared with no significant difference.

Experimental result：

A groups：The symptom of the preceding patient of medication is nervous, shortness of breath, is felt suffocated, and the irregular panic attacks in chest, is breathed on foot, legs and feet without Power, electrocardiogram show blood supply wretched insufficiency, and average S-T segment declines 0.9 millimeter before medication.

That takes patients with coronary artery disease after 6 courses for the treatment of the results are shown in Table 2.

Table 2

。

B groups：The evaluated order of severity of thrombosis patients is suitable before medication, and patient is in age, sex, thrombosis position, disease Journey, clinical manifestation etc. comparing difference are without conspicuousness；Medicine of the present invention, without complication, has no haemorrhage during thrombolysis Shape, occasionally there is patient slight gastrointestinal reaction occur, disappeared after giving anti symptom treatment.

The experimental result of thrombosis patients is shown in Table 3 after taking 60 days.

Table 3

。

Model case：So-and-so is shut out, 55 years old, patients with coronary heart disease, finds there is old antetheca cardiac muscle stalk in medication the first two months Extremely, electrocardiogram V2-V4QS ripples, T ripples be inverted, take 1 oral liquid of embodiment after 2 months patient symptom be obviously improved, electrocardiogram recover Normally.

Above content describes the general principle and principal character of the present invention, and the present invention is not limited to the above embodiments, Without departing from the spirit and scope of the present invention, various changes and modifications of the present invention are possible, and these changes and improvements are all Fall into scope of the claimed invention.

Claims (10)

1. a kind of sophora bud oral liquid for treating cardiovascular and cerebrovascular diseases, it is characterised in that in terms of weight fraction, bulk drug is by following component It is made：500 parts of the sophora bud, red sage root 250-350 parts, Radix Angelicae Sinensis 200-300 parts, Radix Codonopsis 200-300 parts, fleece-flower root 200-300 parts, the Radix Astragali 150-250 parts, ginseng 200-300 parts, radix paeoniae rubrathe 150-250 parts, pseudo-ginseng 200-300 parts, rhizoma Gastrodiae 200-300 parts, fruit of Chinese wolfberry 200- 300 parts, safflower 100-200 parts, Chinese cassia tree 200-300 parts, cortex acanthopanacis 250-350 parts, cassia seed 200-300 parts, day lily 350- 450 parts, reticulate millettia 300-400 parts, hairyvein agrimony 250-350 parts, gynostemma pentaphylla 250-350 parts, folium cortex eucommiae 250-350 parts, honeysuckle 250-350 parts, cultivated land 250-350 parts, ground bettle 200-300 parts, earthworm 150-250 parts, bluish dogbane 250-350 parts, radix glycyrrhizae 150-250 parts.

2. the sophora bud oral liquid for the treatment of cardiovascular and cerebrovascular diseases according to claim 1, it is characterised in that red sage root 270-340 Part, when being classified as 210-290 parts, Radix Codonopsis is 220-290 parts.

3. the sophora bud oral liquid for the treatment of cardiovascular and cerebrovascular diseases according to claim 1, it is characterised in that fleece-flower root 210-280 Part, the Radix Astragali is 160-240 parts, and ginseng is 220-280 parts, and the radix paeoniae rubrathe is 160-240 parts.

4. the sophora bud oral liquid for the treatment of cardiovascular and cerebrovascular diseases according to claim 1, it is characterised in that pseudo-ginseng 230-280 Part, rhizoma Gastrodiae is 230-270 parts, and the fruit of Chinese wolfberry is 220-270 parts.

5. the sophora bud oral liquid for the treatment of cardiovascular and cerebrovascular diseases according to claim 1, it is characterised in that safflower 130-170 Part, Chinese cassia tree is 220-270 parts, and cortex acanthopanacis is 280-320 parts, and cassia seed is 230-280 parts.

6. the sophora bud oral liquid for the treatment of cardiovascular and cerebrovascular diseases according to claim 1, it is characterised in that day lily 360-430 Part, reticulate millettia is 320-390 parts, and hairyvein agrimony is 270-330 parts, and gynostemma pentaphylla is 270-340 parts.

7. the sophora bud oral liquid for the treatment of cardiovascular and cerebrovascular diseases according to claim 1, it is characterised in that folium cortex eucommiae 270-320 Part, honeysuckle is 280-320 parts, and cultivated land is 280-320 parts, and ground bettle is 230-270 parts.

8. the sophora bud oral liquid for the treatment of cardiovascular and cerebrovascular diseases according to claim 1, it is characterised in that earthworm 170-230 Part, bluish dogbane is 280-320 parts, and radix glycyrrhizae is 180-210 parts.

9. the sophora bud oral liquid for the treatment of cardiovascular and cerebrovascular diseases according to claim 1, it is characterised in that former in terms of weight fraction Material medicine is made up of following component：500 parts of the sophora bud, 300 parts of the red sage root, 250 parts of Radix Angelicae Sinensis, 250 parts of Radix Codonopsis, 250 parts of the fleece-flower root, the Radix Astragali 200 parts, 250 parts of ginseng, 200 parts of the radix paeoniae rubrathe, 250 parts of pseudo-ginseng, 250 parts of rhizoma Gastrodiae, 250 parts of the fruit of Chinese wolfberry, 150 parts of safflower, Chinese cassia tree 250 Part, 300 parts of cortex acanthopanacis, 250 parts of cassia seed, 400 parts of day lily, 350 parts of reticulate millettia, 300 parts of hairyvein agrimony, 300 parts of gynostemma pentaphylla, Du 300 parts of Zhong Ye, 300 parts of honeysuckle, 300 parts of cultivated land, 250 parts of ground bettle, 200 parts of earthworm, 300 parts of bluish dogbane, 200 parts of radix glycyrrhizae.

10. the preparation method of the sophora bud oral liquid of the treatment cardiovascular and cerebrovascular diseases according to claim 1, it is characterised in that bag Include following steps：

（1）The raw material weighed up is put into decocting container, adds water, boiled rear slow fire is decocted 20-40 minutes, and maintenance boiling water is Can；Wherein the weight ratio of Chinese medicine material and water is 1:（3-5）；

（2）By well-done medical filtration；It is filling.