CN107661733B - Is used for13Reaction kettle for synthesizing C-urea - Google Patents
Is used for13Reaction kettle for synthesizing C-urea Download PDFInfo
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- CN107661733B CN107661733B CN201610605180.5A CN201610605180A CN107661733B CN 107661733 B CN107661733 B CN 107661733B CN 201610605180 A CN201610605180 A CN 201610605180A CN 107661733 B CN107661733 B CN 107661733B
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- 239000004202 carbamide Substances 0.000 title claims abstract description 28
- 230000002194 synthesizing effect Effects 0.000 title claims abstract description 15
- 238000006243 chemical reaction Methods 0.000 claims abstract description 47
- 238000007789 sealing Methods 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims description 17
- 238000004891 communication Methods 0.000 claims description 16
- 239000000126 substance Substances 0.000 claims description 10
- 230000000149 penetrating effect Effects 0.000 claims description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract description 10
- 238000003786 synthesis reaction Methods 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 5
- 238000001514 detection method Methods 0.000 abstract description 3
- 239000000523 sample Substances 0.000 abstract description 2
- 239000007789 gas Substances 0.000 description 41
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 7
- 238000004140 cleaning Methods 0.000 description 7
- 241000590002 Helicobacter pylori Species 0.000 description 6
- 229940037467 helicobacter pylori Drugs 0.000 description 6
- 238000010926 purge Methods 0.000 description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 5
- 229910052799 carbon Inorganic materials 0.000 description 5
- 239000001307 helium Substances 0.000 description 5
- 229910052734 helium Inorganic materials 0.000 description 5
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 5
- XSQUKJJJFZCRTK-OUBTZVSYSA-N Urea-13C Chemical compound N[13C](N)=O XSQUKJJJFZCRTK-OUBTZVSYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000002912 waste gas Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 208000018522 Gastrointestinal disease Diseases 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 208000010643 digestive system disease Diseases 0.000 description 2
- 229910001873 dinitrogen Inorganic materials 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 208000018685 gastrointestinal system disease Diseases 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000012495 reaction gas Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 241001522296 Erithacus rubecula Species 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 206010019375 Helicobacter infections Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 108010046334 Urease Proteins 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000002457 bidirectional effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 238000012134 rapid urease test Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
- B01J8/008—Details of the reactor or of the particulate material; Processes to increase or to retard the rate of reaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/02—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of urea, its salts, complexes or addition compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2208/00—Processes carried out in the presence of solid particles; Reactors therefor
- B01J2208/00008—Controlling the process
- B01J2208/00017—Controlling the temperature
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2208/00—Processes carried out in the presence of solid particles; Reactors therefor
- B01J2208/00008—Controlling the process
- B01J2208/00539—Pressure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Exhaust Gas After Treatment (AREA)
Abstract
The invention relates to a method for13The reaction kettle for synthesizing the C-urea comprises a pressure-resistant bottle body (100) and a communicating part (200); wherein, intercommunication part (200) include inside hollow cross connecting pipe (210) and run through intake pipe (220) of cross connecting pipe (210), cross connecting pipe (210) include first connector (211), second connector (212), third connector (213), fourth connector (214), intake pipe (220) with seal between third connector (213), just intake pipe (220) run through first connector (211) with third connector (213) and extend into inside the pressure-resistant bottle (100). The reaction kettle is convenient to13CO and NH3The exhaust gas before gas filling and after reaction is finished can be discharged simply and conveniently, and the urea synthesis reaction can be directly used after sealing, and can be connected with a related detection probe to detect the reaction at any time.
Description
Technical Field
The invention relates to chemical equipment, in particular to a chemical equipment for chemical equipment13A reaction kettle for synthesizing C-urea.
Background
Helicobacter pylori (Hp), a unipolar, multiflagellated, blunt-ended, helically-curved bacterium, was first discovered in 1982 by Barry marshall (Barry j. marshall) and robin warren (j. robinwarren), both of which thus received the 2005 nobel prize in physiology or medicine. Subsequent studies have confirmed that this bacterium does cause gastritis, chronic gastroenteritis, gastric ulcer, duodenal ulcer, non-ulcer dyspepsia and partial gastric cancer, helicobacter pylori has therefore received attention from the medical community, and the relationship between helicobacter pylori infection and gastrointestinal disease has been a hot spot and difficulty in global gastrointestinal disease infection studies for over 30 years.
The current methods for detecting and identifying helicobacter pylori (Hp) mainly comprise a rapid urease test, a helicobacter pylori (Hp) antibody test,13C or14C, expiration test, pathological tissue section, bacterial culture and the like. Wherein,13c or14C, the accuracy of the breath test is the highest and reaches more than 95-96%.13The C-urea is produced13The C breath test detection reagent needs raw material medicines, and the scale preparation technology and the process thereof have difficulties.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: provide a device for13A reaction kettle for synthesizing C-urea, which solves the problem that no proper reaction kettle for containing in the prior art is available13CO、S、NH3So that the urea is synthesized and the subsequent exhaust work of waste gas can be finished.
In order to solve the problems, the invention provides the following technical scheme: provide a device for13The reaction kettle for synthesizing the C-urea comprises a pressure-resistant bottle body for containing reaction substances and a communicating part arranged on the inlet of the pressure-resistant bottle body; wherein, the intercommunication part includes inside hollow cross connecting pipe and runs through the intake pipe of cross connecting pipe, the cross connecting pipe include with the first connector of withstand voltage bottle entry intercommunication, the second connector of intercommunication installation relief valve, with the relative third connector that sets up of first connector, be used for the fourth connector of gaseous business turn over, the intake pipe with seal between the third connector, just the intake pipe runs through first connector with the third connector extends and gets into inside the withstand voltage bottle.
In the invention provided for13In the reaction kettle for synthesizing the C-urea, the communication part also comprises a first extension pipeline for connecting the first connecting port with the inlet of the pressure-resistant bottle body; the first extending pipeline is hollow, and one end of the first extending pipeline is connected with the first extending pipelineOne end of the pressure-resistant bottle body is communicated with the inlet of the pressure-resistant bottle body in a sealing way, and the other end of the pressure-resistant bottle body is communicated with the inlet of the pressure-resistant bottle body in a sealing way.
In the invention provided for13In the reaction kettle for synthesizing the C-urea, the communicating part further comprises a second extending pipeline connected to the second connector, and the second extending pipeline is provided with the pressure release valve; one end of the second extension pipeline is communicated with the second connecting port in a sealing mode, and the other end of the second extension pipeline is sealed.
In the invention provided for13In the reaction kettle for synthesizing the C-urea, the communication part further comprises a third extending pipeline connected to the third connecting port, and one end of the air inlet pipe close to the third connecting port is accommodated in the third extending pipeline; one end of the third extending pipeline is communicated with the third connecting port in a sealing mode, and a sealing structure is arranged in a gap between the third extending pipeline and the air inlet pipe.
In the invention provided for13In the reaction kettle for synthesizing the C-urea, the other end of the third extending pipeline, which is far away from the third connecting port, is connected with an air inlet pipe extending pipeline, and the air inlet pipe extending pipeline is hollow and communicated with the air inlet pipe; and a first spherical control valve and a temperature and pressure detector are arranged on the air inlet pipe extending pipeline.
In the invention provided for13In the reaction kettle for synthesizing the C-urea, the communicating part further comprises a fourth extending pipeline connected to the fourth connecting port, one end of the fourth extending pipeline is communicated with the fourth connecting port in a sealing manner, and the other end of the fourth extending pipeline is communicated with a raw material gas source or a gas outlet pipeline; and a second ball control valve is arranged on the fourth extension pipeline.
The implementation of the invention has the following beneficial effects: the reaction kettle of the invention is convenient13CO and NH3The exhaust gas before gas filling and after reaction is finished can be simply and conveniently discharged, and the urea synthesis reaction can be directly used after sealing, and can be connected with a related detection probe to monitor the reaction in real time.
Drawings
The invention will be further described with reference to the accompanying drawings and examples, in which:
FIG. 1 is a schematic perspective view of a preferred embodiment of a reaction vessel according to the present invention;
FIG. 2 is a front view of a preferred embodiment of the reactor of the present invention;
FIG. 3 is a schematic structural view of a communicating part of a reaction vessel according to the present invention.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to the accompanying drawings.
13The main component of the breath test reagent used in the C breath test is13C-urea, i.e. use13C marks carbon element in urea, also called carbon [ C ]13C-Urea [ sic ]13CO(NH2)2Or carbon [ C ]13C-Urea, carried thereby13C is12An isotope of C. If helicobacter pylori (Hp) is present in the stomach of a patient, the urease produced will break down the urea into13CO2Checking in the expired air of the patient with a matching instrument13C, the infection of helicobacter pylori (Hp) can be diagnosed. Comprises13C-labelled carbon [13C-urea large-scale preparation technology and process are always industrial difficulties. The invention is based on Franz r.a. and applegathf13C-Urea preparation, the basic principle is described in organic chemistry (1961), volume 26, page 2604-2605, and the chemical equation of the reaction is as follows:
13CO+S+2NH3→H2N13CONH2+H2S
due to the reaction system13CO and NH3In the reaction flask is liquid, S is solid, in order to realize13CO and NH3Filling of gas and reaction of H2S gas discharge, installing a communicating part 200 on the pressure-resistant bottle body 100, wherein the communicating part 200 mainly comprises a cross connecting pipe 210 and an air inlet pipe 220 which penetrates through the cross connecting pipe 210 from top to bottom and extends into the pressure-resistant bottle body 100, the cross connecting pipe 210 comprises a fourth connecting port 214 for air to enter and exit, and the cleaning gas mainly comprisesFor the purpose of introducing nitrogen gas and helium gas into the inside of the pressure-resistant bottle body 100 along the gas inlet pipe 220, air or H generated by the reaction is discharged from the fourth connection port 2142S gas; in the raw material gas13CO and NH3During filling, in the gaseous state13CO and NH3Enters from the fourth connection port 214 and flows into the pressure-resistant bottle body 100, and the pressure-resistant bottle body 100 has a lower inside than that of the pressure-resistant bottle body 100 by the cooling action of the ultra-low-temperature coolant13CO and NH3Temperature of boiling point, and thus will be gaseous13CO and NH3Cooling to liquid, and reacting with the pre-filled elemental sulfur to generate urea.
FIG. 1 shows a three-dimensional structure of a preferred embodiment of the reaction vessel of the present invention, as shown in FIG. 1, for use in13The reaction kettle for synthesizing the C-urea comprises a pressure-resistant bottle body 100 and a communicating part 200. The pressure-resistant bottle 100 is used to contain a reaction substance, including a liquid13CO and NH3And elemental sulfur in the solid state. The communicating member 200 is installed at the inlet of the pressure-resistant bottle body 100, and the communicating member 200 includes a cross-shaped connecting pipe 210 having a hollow interior and an air inlet pipe 220 penetrating the cross-shaped connecting pipe 210; the cross-shaped connecting pipe 210 comprises four connecting ports, namely a first connecting port 211, a second connecting port 212, a third connecting port 213 and a fourth connecting port 214, the cross-shaped connecting pipe 210 is hollow, and the four connecting ports are communicated with each other; the first connection port 211 communicates with the inlet of the pressure-resistant bottle body 100, and the connection through the first connection port 211 allows the interior space of the pressure-resistant bottle body 100 to communicate with the interior space of the cross connection tube 210 without an obstacle; the third connection port 213 is disposed opposite to the first connection port 211, and the air inlet pipe 220 having a long straight pipe shape penetrates through the first connection port 211 and the third connection port 213 and extends into the inside of the pressure-resistant bottle body 100; the two remaining connectors of the cross-shaped connecting pipe 210 are a second connector 212 and a fourth connector 214, the second connector 212 is communicated with a pressure relief valve 240, and the pressure relief valve is used for keeping the pressure inside the cross-shaped connecting pipe 210 and the pressure-resistant bottle body 100 not exceeding a preset value, so that the occurrence of a safety situation caused by overpressure is avoided; the fourth connection port 214 is provided opposite to the second connection port 212, is a bidirectional passage, and may be an inlet for the raw material gas or an outlet for the exhaust gas.
In addition, the air inlet pipe 220 and the third connection port 213 are sealed, that is, the third connection port 213 is not used for the ingress and egress of any substance, and the sealing mechanism in the gap between the air inlet pipe 220 and the third connection port 213 is used for sealing, the third connection port 213 is used for allowing the air inlet pipe 220 to pass through the inside thereof, and the purge gas mainly comprises nitrogen gas and helium gas entering the inside of the pressure-resistant bottle body 100 along the air inlet pipe 220.
FIG. 2 shows a front view of the preferred embodiment of the reaction vessel of the present invention, and as shown in FIG. 2, the connection part 200 further comprises a first extension pipe 231 connecting the first connection port 211 and the inlet of the pressure-resistant bottle 100, a second extension pipe 232 connected to the second connection port 212, a third extension pipe 233 connected to the third connection port 213, and a fourth extension pipe 234 connected to the fourth connection port 214.
The first extension pipe 231 is hollow inside, and has one end in sealed communication with the first connection port 211 and the other end in sealed communication with the inlet of the pressure-resistant bottle 100. By the connection action of the first extension pipe 231, the communication member 200 is fixed to the inlet of the pressure-resistant bottle body 100, and the communication between the inner space of the pressure-resistant bottle body 100 and the inner space of the cross connection pipe 210 is achieved.
A pressure release valve 240 is arranged on the second extension pipeline 232 to ensure that the pressure in the reaction system is lower than a preset value; one end of the second extension pipe 232 is in sealed communication with the second connection port 212, and the other end is sealed. Preferably, the pressure release valve 240 is a mechanical proportional unloading valve, which can set a critical pressure automatically, and automatically open to release pressure when the critical pressure is greater than a set value.
One end of the third extension pipeline 233 is in sealed communication with the third connecting port 213, and the other end far away from the third connecting port 213 is connected with the extension pipeline of the air inlet pipe 220; one end of the air inlet pipe 220 near the third connection port 213 is accommodated inside the third extension pipe 233, and a seal structure is provided in a gap between the third extension pipe and the air inlet pipe 220. The air inlet pipe 220 is hollow inside the extending pipeline and communicated with the air inlet pipe 220; the air inlet pipe 220 is provided with a first ball control valve 251 and a temperature and pressure detector 260 on an extension pipe. The first ball control valve 251 is used to manually close and open the intake pipe 220 to control the flow of the cleaning gas, and the temperature and pressure detector 260 constantly detects the temperature and pressure state in the intake pipe 220.
One end of the fourth extension pipeline 234 is hermetically communicated with the fourth connecting port 214, and the other end is communicated with a raw material gas source or a gas outlet pipeline; as mentioned above, the fourth connection port 214 has a dual function, the raw material gas is introduced into or exhausted from the fourth connection port 214, and when the fourth extension pipe 234 is connected to the raw material gas source, the raw material gas flows through the fourth connection port 214, the first connection port 211 and then enters the pressure-resistant bottle 100; when the fourth extending pipe 234 is connected to the air outlet pipe, the exhaust gas flows through the first connecting port 211 and the fourth connecting port 214 in sequence, and then enters the air outlet pipe to be discharged. The exhaust gas includes gas such as purge gas flowing in from the gas inlet pipe 220 and air taken out from the pressure-resistant bottle 100 when the reaction vessel is purged; further comprises a cleaning gas flowing in from the gas inlet pipe 220 after the urea synthesis reaction is completed and H taken out from the pressure-resistant bottle body 1002S, and the like. A second ball control valve 252 is disposed on the fourth extension pipe 234 to control the closing and opening of the fourth connection port 214, thereby controlling the intake of the raw material gas or the exhaust of the exhaust gas.
FIG. 3 shows the structure of the communicating part 200 of the reaction vessel of the present invention, and as shown in FIG. 3, the gas inlet pipe 220 having a long straight pipe shape penetrates the first connecting port 211 and the third connecting port 213 and extends into the inside of the pressure-resistant bottle body 100; the intake pipe 220 functions to introduce the purge gas into the pressure-resistant bottle 100, but does not have a function of exhausting any gas, i.e., the intake pipe 220 has only a unidirectional intake function. As the four basic steps of purging the reaction kettle, filling reaction gas, urea synthesis reaction and removing waste gas are respectively involved in the use process of the reaction kettle, the structure of the reaction kettle is combined for description.
When the reaction kettle is purged, the first spherical control valve 251 and the second spherical control valve 252 are both in an open state, the air inlet pipe 220 is communicated with a cleaning air source, the fourth connecting port 214 is communicated with an air outlet pipeline, and the cleaning air at the moment is helium; helium enters the pressure-resistant bottle body 100 along the air inlet pipe 220 and is mixed with air in the pressure-resistant bottle body 100, the mixed gas sequentially flows through the first connecting port 211 and the fourth connecting port 214 and enters the air outlet pipeline, and after a period of helium purging, residual air in the reaction kettle is emptied before inflation, and then the first spherical control valve 251 and the second spherical control valve 252 are closed.
When reaction gas is filled, the second spherical control valve 252 is opened, the first spherical control valve 251 is still in a closed state, the fourth connecting port 214 is communicated with a raw material gas source, raw material gas can sequentially flow through the fourth connecting port 214 and the first connecting port 211 to enter the pressure-resistant bottle body 100, the raw material gas is cooled to be in a liquid state under the action of strong freezing, the raw material gas falls into the bottom of the pressure-resistant bottle body 100, the raw material gas continuously flows into the pressure-resistant bottle body to fill the raw material gas, and the first spherical control valve 251 and the second spherical control valve 252 are closed to perform subsequent reaction.
When the urea synthesis reaction is carried out, the first spherical control valve 251 and the second spherical control valve 252 are both in a closed state, at this time, no substance flows between the whole reaction kettle and the outside, and substances in the reaction kettle13CO、S、NH3Reaction to form carbon [13C-Urea and H2S。
When the exhaust gas is purged, the urea synthesis reaction is completed. Because other raw materials are all added in excess so as to ensure that13Since CO can be fully reacted, S, NH which is not completely reacted remains in the reaction kettle3And H formed by reaction2And S. The first spherical control valve 251 and the second spherical control valve 252 are both in an open state, the air inlet pipe 220 is communicated with a cleaning air source, the fourth connecting port 214 is communicated with an air outlet pipeline, and the cleaning air at the moment is nitrogen; the nitrogen enters the pressure-resistant bottle body 100 along the air inlet pipe 220 and is mixed with the air in the pressure-resistant bottle body 100, the mixed air sequentially flows through the first connecting port 211 and the fourth connecting port 214 and enters the air outlet pipeline, and after a period of nitrogen purging, the mixed air is used for evacuating residual waste gas in the reaction kettle before inflation, so that the first spherical control valve 251 and the second spherical control valve 252 are closed.
While the present invention has been described with reference to the embodiments shown in the drawings, the present invention is not limited to the embodiments, which are illustrative and not restrictive, and it will be apparent to those skilled in the art that various changes and modifications can be made therein without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (3)
1. Is used for13The reaction kettle for synthesizing the C-urea is characterized by comprising a pressure-resistant bottle body (100) for containing reaction substances and a communication part (200) arranged on the inlet of the pressure-resistant bottle body (100); the communicating part (200) comprises a cross connecting pipe (210) with a hollow interior and an air inlet pipe (220) penetrating through the cross connecting pipe (210), the cross connecting pipe (210) comprises a first connecting port (211) communicated with an inlet of the pressure-resistant bottle body (100), a second connecting port (212) communicated with and provided with a pressure relief valve (240), a third connecting port (213) opposite to the first connecting port (211), and a fourth connecting port (214) used for air to enter and exit, the air inlet pipe (220) and the third connecting port (213) are sealed, and the air inlet pipe (220) penetrates through the first connecting port (211) and the third connecting port (213) and extends into the pressure-resistant bottle body (100);
the communication part (200) further comprises a second extension pipeline (232) connected to the second connection port (212), and the pressure relief valve (240) is mounted on the second extension pipeline (232); one end of the second extension pipeline (232) is in sealed communication with the second connecting port (212), and the other end of the second extension pipeline (232) is sealed;
the communication component (200) further comprises a third extension pipeline (233) connected to the third connecting port (213), and one end of the air inlet pipe (220) close to the third connecting port (213) is accommodated in the third extension pipeline (233);
the other end, far away from the third connecting port (213), of the third extending pipeline (233) is connected with an extending pipeline of an air inlet pipe (220), and the extending pipeline of the air inlet pipe (220) is hollow and communicated with the air inlet pipe (220); a first spherical control valve (251) and a temperature and pressure detector (260) are arranged on an extending pipeline of the air inlet pipe (220);
the communication part (200) further comprises a fourth extension pipeline (234) connected to the fourth connecting port (214), one end of the fourth extension pipeline (234) is in sealed communication with the fourth connecting port (214), and the other end of the fourth extension pipeline (234) is communicated with a raw material gas source or a gas outlet pipeline; a second ball control valve (252) is disposed on the fourth extension line (234).
2. Use according to claim 1 for13The reaction kettle for synthesizing the C-urea is characterized in that the communication component (200) further comprises a first extension pipeline (231) which is connected with the first connecting port (211) and the inlet of the pressure-resistant bottle body (100); the first extension pipeline (231) is hollow, one end of the first extension pipeline is communicated with the first connecting port (211) in a sealing mode, and the other end of the first extension pipeline is communicated with the inlet of the pressure-resistant bottle body (100) in a sealing mode.
3. Use according to claim 1 for13The reaction kettle for synthesizing the C-urea is characterized in that one end of the third extension pipeline (233) is in sealed communication with the third connecting port (213), and a sealing structure is arranged in a gap between the third extension pipeline (233) and the air inlet pipe (220).
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610605180.5A CN107661733B (en) | 2016-07-27 | 2016-07-27 | Is used for13Reaction kettle for synthesizing C-urea |
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| CN201610605180.5A CN107661733B (en) | 2016-07-27 | 2016-07-27 | Is used for13Reaction kettle for synthesizing C-urea |
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| CN107661733A CN107661733A (en) | 2018-02-06 |
| CN107661733B true CN107661733B (en) | 2020-10-27 |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2864181Y (en) * | 2005-12-16 | 2007-01-31 | 中国科学院力学研究所 | Feed equipment with injection function |
| CN202010548U (en) * | 2011-03-15 | 2011-10-19 | 禹州市维立特化工有限公司 | Air intake device of chlorine reaction kettle |
| CN202015607U (en) * | 2011-03-18 | 2011-10-26 | 东营市诺尔化工有限责任公司 | Over-temperature and over-pressure automatically-controllable reaction kettle |
| CN102946987A (en) * | 2010-03-31 | 2013-02-27 | 科学工业研究委员会 | Hydrogen/syngas generator |
| CN204017807U (en) * | 2014-03-05 | 2014-12-17 | 华东理工大学 | Catalyzed chemical reaction device and for the air supply part of this device |
| CN205095752U (en) * | 2015-11-04 | 2016-03-23 | 江西万里药业有限公司 | Intermediate's improved generation gasification feed arrangement |
| CN205109638U (en) * | 2015-11-11 | 2016-03-30 | 临海市建新化工有限公司 | Sulfur bromide reation kettle |
Family Cites Families (1)
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Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2864181Y (en) * | 2005-12-16 | 2007-01-31 | 中国科学院力学研究所 | Feed equipment with injection function |
| CN102946987A (en) * | 2010-03-31 | 2013-02-27 | 科学工业研究委员会 | Hydrogen/syngas generator |
| CN202010548U (en) * | 2011-03-15 | 2011-10-19 | 禹州市维立特化工有限公司 | Air intake device of chlorine reaction kettle |
| CN202015607U (en) * | 2011-03-18 | 2011-10-26 | 东营市诺尔化工有限责任公司 | Over-temperature and over-pressure automatically-controllable reaction kettle |
| CN204017807U (en) * | 2014-03-05 | 2014-12-17 | 华东理工大学 | Catalyzed chemical reaction device and for the air supply part of this device |
| CN205095752U (en) * | 2015-11-04 | 2016-03-23 | 江西万里药业有限公司 | Intermediate's improved generation gasification feed arrangement |
| CN205109638U (en) * | 2015-11-11 | 2016-03-30 | 临海市建新化工有限公司 | Sulfur bromide reation kettle |
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| CN107661733A (en) | 2018-02-06 |
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