CN107647877B - Positron emission medical imaging system and imaging method - Google Patents
Positron emission medical imaging system and imaging method Download PDFInfo
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- CN107647877B CN107647877B CN201711048695.0A CN201711048695A CN107647877B CN 107647877 B CN107647877 B CN 107647877B CN 201711048695 A CN201711048695 A CN 201711048695A CN 107647877 B CN107647877 B CN 107647877B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computerised tomographs
- A61B6/037—Emission tomography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/42—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis
- A61B6/4208—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
- A61B6/5205—Devices using data or image processing specially adapted for radiation diagnosis involving processing of raw data to produce diagnostic data
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
- A61B6/5294—Devices using data or image processing specially adapted for radiation diagnosis involving using additional data, e.g. patient information, image labeling, acquisition parameters
Abstract
The invention relates to the technical field of molecular imaging and medical image imaging, in particular to a positron emission medical imaging system and an imaging method. Compared with other positron emission tomography medical imaging methods, the method can accurately position the focus molecules by only using a PET means, overcomes the defect that the traditional single-mode PET cannot clearly image, simultaneously compares the obtained gamma spectrum with the focus molecules in a database, determines the focus molecular structure and avoids the physiological dissection process.
Description
Technical Field
The invention relates to the technical field of molecular imaging and medical image imaging, in particular to a positron emission medical imaging system and an imaging method.
Background
The positron emission tomography PET technology is widely accepted as a new molecular imaging technology for medical applications and contributions. The PET technology takes positron nuclide carried by probe molecules as a positron emission source, and annihilates with target molecules or electrons in target organs to release two high-energy gamma photons with the energy of 511keV for radiography. Compared with the traditional imaging technology, the signal photons of the PET technology have short wavelength and strong penetrability, are not easily interfered by background scattering and auger action of other electrons, cannot be hindered by bones in a body and the like, and is an advanced medical imaging technology for observing and diagnosing pathological lesions on a molecular scale. The PET medical imaging technology can be applied to the diagnosis of malignant tumors, nervous system and cardiovascular diseases, which cannot be realized by other medical imaging technologies.
At present, a Positron Emission Tomography (PET) device mainly identifies gamma photons with the energy of 511keV, the two photons are on a straight line and cannot form a focus, so that the imaging accuracy is poor, medical misjudgment is caused, and generally the PET needs to be combined with MR or CT to construct a multimode imaging device. However, in practical situations, molecules in biological tissues are constantly vibrated and rotated, electrons therein are constantly moved at high speed, and the mutual correlation between the movements results in that the emitted gamma photons contain more broadening information, so that the structure and the position of the molecules can be more finely distinguished, and the imaging accuracy is improved.
On the other hand, because the traditional PET only collects gamma photons in the 180-degree direction, the two photons do not carry any structural information of focus molecules, and meanwhile, the reverse extension lines of the emergent directions of the two photons cannot intersect to one point, the focus position cannot be clearly positioned, the multi-mode diagnosis method is formed by usually combining MR, CT and other means for auxiliary positioning, the cost is high, and the design is complex; the molecules of the lesion must be confirmed by further biopsy, which requires biological dissection.
In order to promote the development of the technical field of molecular imaging and medical image imaging, the invention provides a positron emission medical imaging system and an imaging method.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a positron emission medical imaging system and an imaging method, which can accurately fuse position and structure information by researching momentum distribution of electrons, provide a theoretical model for accurate resolution and molecular image reconstruction of gamma photon signals, utilize molecular structure information carried in gamma photon Doppler spectrums, realize position information of traditional positron tomography, further reconstruct molecular structure information, utilize molecular structure information carried by spectrum broadening, avoid physiological dissection process, realize imaging and simultaneously realize synchronous auxiliary diagnosis. The purpose of the invention is realized by the following technical scheme:
a positron emission medical imaging system comprises a measuring module, a data processing module, an analyzing module and a database, wherein the measuring module is used for measuring the outgoing angle and energy distribution information of two gamma photons released after positron-electron annihilation and acquiring Doppler broadening information of a gamma spectrum, the data processing module is respectively connected with the measuring module, the analyzing module and the database and is used for analyzing and processing the information acquired by the measuring module and acquiring the wave function and momentum distribution information of electrons and positrons in molecules, the database is a focus molecule database, and the analyzing module is used for comparing the wave function and the momentum distribution information with the database, determining the annihilation position and the focus molecular structure of the positrons in the molecules and positioning the outgoing position and the molecular position of the gamma photons.
Further, the device also comprises a display module, and the display module is connected with the data processing module.
Furthermore, the system also comprises a human-computer interaction module, and the human-computer interaction module is connected with the data processing module.
An imaging method of a positron emission medical imaging system comprises the steps of measuring the outgoing angle and energy distribution information of two gamma photons released after positron-electron annihilation through a measuring module, obtaining Doppler broadening information of a gamma spectrum, transmitting the Doppler broadening information to a data processing module, correspondingly obtaining wave function and momentum distribution information of electrons and positrons in molecules, comparing the wave function and momentum distribution information with a focus molecule database through an analysis module, simultaneously determining annihilation positions and focus molecular structures of the positrons in the molecules, and accurately positioning the outgoing positions of the gamma photons and the focus molecular positions.
The invention has the beneficial effects that: compared with other positron emission tomography medical imaging methods, the method can accurately position the focus molecules by using a PET means according to the fact that the two photon emitting directions deviate from 180 degrees due to the Doppler effect of high-speed movement of electrons in the molecules, and simultaneously compares the obtained gamma spectrum with the focus molecules in a database to determine the focus molecular structure, thereby avoiding the physiological anatomy process.
Drawings
FIG. 1 is a block diagram of a positron emitting medical imaging system of the present invention.
Detailed Description
The technical solutions of the present invention are further described in detail below with reference to the accompanying drawings, but the scope of the present invention is not limited to the following.
As shown in fig. 1, a positron emission medical imaging system includes a measurement module, a data processing module, an analysis module and a database, wherein the measurement module is configured to measure an emission angle and energy distribution information of two gamma photons released after positron-electron annihilation, and acquire doppler spread information of a gamma spectrum, the data processing module is connected to the measurement module, the analysis module and the database, respectively, and is configured to analyze and process the information acquired by the measurement module, and acquire a wave function and momentum distribution information of electrons and positrons in molecules, the database is a focus molecule database, and the analysis module is configured to compare the wave function and momentum distribution information with the database, determine an annihilation position and a focus molecule structure of the positrons in the molecules, and locate the emission position of the gamma photons and the position of the focus molecules.
In a preferred embodiment, the system further comprises a display module, and the display module is connected with the data processing module.
In a preferred embodiment, the system further comprises a human-computer interaction module, and the human-computer interaction module is connected with the data processing module.
An imaging method of a positron emission medical imaging system comprises the steps of measuring the outgoing angle and energy distribution information of two gamma photons released after positron-electron annihilation through a measuring module, obtaining Doppler broadening information of a gamma spectrum, transmitting the Doppler broadening information to a data processing module, correspondingly obtaining wave function and momentum distribution information of electrons and positrons in molecules, comparing the wave function and momentum distribution information with a focus molecule database through an analysis module, simultaneously determining annihilation positions and focus molecular structures of the positrons in the molecules, and accurately positioning the outgoing positions of the gamma photons and the focus molecular positions. The method provides a theoretical model for the accurate resolution and molecular image reconstruction of gamma photon signals by researching the momentum distribution of electrons and accurately fusing position and structure information. The molecular structure information carried in the gamma photon Doppler spectrum is utilized, not only can the position information of the traditional positron tomography be realized, but also the molecular structure information can be further reconstructed, the molecular structure information carried by the frequency spectrum broadening is utilized, the physiological anatomy process is avoided, and the imaging and the diagnosis are completed at the same time.
The foregoing is illustrative of the preferred embodiments of this invention, and it is to be understood that the invention is not limited to the precise form disclosed herein and that various other combinations, modifications, and environments may be resorted to, falling within the scope of the concept as disclosed herein, either as described above or as apparent to those skilled in the relevant art. And that modifications and variations may be effected by those skilled in the art without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (4)
1. A single-mode positron emission medical imaging system capable of realizing accurate positioning is characterized by comprising a measuring module, a data processing module, an analysis module and a database, the measuring module is used for measuring the outgoing angle and energy distribution information of two gamma photons released after positron-electron annihilation and acquiring Doppler broadening information of a gamma spectrum, the data processing module is respectively connected with the measuring module, the analysis module and the database, used for analyzing and processing the information acquired by the measuring module and acquiring the wave function and momentum distribution information of electrons and positrons in molecules, the database is a focus molecule database, and the analysis module is used for comparing wave function and momentum distribution information with the database, determining annihilation positions and focus molecule structures of positrons in molecules, and positioning gamma photon emergence positions and focus molecule positions.
2. The single mode positron emission medical imaging system of claim 1 further comprising a display module, wherein said display module is connected to said data processing module.
3. The single-mode positron emission medical imaging system of claim 1, further comprising a human-computer interaction module, wherein the human-computer interaction module is connected with the data processing module.
4. An imaging method of a single-mode positron emission medical imaging system capable of achieving precise positioning as claimed in any one of claims 1 to 3, wherein a measurement module measures the emission angle and energy distribution information of two gamma photons released after positron-electron annihilation to obtain Doppler broadening information of a gamma spectrum, the Doppler broadening information is transmitted to a data processing module to correspondingly obtain the wave function and momentum distribution information of electrons and positrons in molecules, an analysis module is used for comparing the wave function and momentum distribution information with a focus molecule database, and meanwhile, the annihilation position and focus molecule structure of positrons in molecules are determined, and the emission position of gamma photons and the position of focus molecules are accurately positioned.
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