CN107638176A - A kind of application of hydrogel in the electrode for preparing detection electrocorticogram - Google Patents
A kind of application of hydrogel in the electrode for preparing detection electrocorticogram Download PDFInfo
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- CN107638176A CN107638176A CN201710806112.XA CN201710806112A CN107638176A CN 107638176 A CN107638176 A CN 107638176A CN 201710806112 A CN201710806112 A CN 201710806112A CN 107638176 A CN107638176 A CN 107638176A
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- electrocorticogram
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- 238000001514 detection method Methods 0.000 title claims abstract description 9
- 239000007788 liquid Substances 0.000 claims abstract description 7
- 229910052751 metal Inorganic materials 0.000 claims description 26
- 239000002184 metal Substances 0.000 claims description 26
- 108010025899 gelatin film Proteins 0.000 claims description 16
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 15
- 239000000758 substrate Substances 0.000 claims description 10
- 229910052697 platinum Inorganic materials 0.000 claims description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 6
- 239000000178 monomer Substances 0.000 claims description 6
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 5
- 229910052737 gold Inorganic materials 0.000 claims description 5
- 239000010931 gold Substances 0.000 claims description 5
- 229920000642 polymer Polymers 0.000 claims description 5
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 3
- 239000003989 dielectric material Substances 0.000 claims description 3
- 239000003292 glue Substances 0.000 claims description 3
- 229910052709 silver Inorganic materials 0.000 claims description 3
- 239000004332 silver Substances 0.000 claims description 3
- GNWBLLYJQXKPIP-ZOGIJGBBSA-N (1s,3as,3bs,5ar,9ar,9bs,11as)-n,n-diethyl-6,9a,11a-trimethyl-7-oxo-2,3,3a,3b,4,5,5a,8,9,9b,10,11-dodecahydro-1h-indeno[5,4-f]quinoline-1-carboxamide Chemical compound CN([C@@H]1CC2)C(=O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)N(CC)CC)[C@@]2(C)CC1 GNWBLLYJQXKPIP-ZOGIJGBBSA-N 0.000 claims description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 claims description 2
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 150000002148 esters Chemical group 0.000 claims description 2
- 239000002504 physiological saline solution Substances 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 229920005573 silicon-containing polymer Polymers 0.000 claims description 2
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims 1
- JPAOMENBKRZQDR-UHFFFAOYSA-N CC=CC.[Na] Chemical compound CC=CC.[Na] JPAOMENBKRZQDR-UHFFFAOYSA-N 0.000 claims 1
- VKEQBMCRQDSRET-UHFFFAOYSA-N Methylone Chemical compound CNC(C)C(=O)C1=CC=C2OCOC2=C1 VKEQBMCRQDSRET-UHFFFAOYSA-N 0.000 claims 1
- JLHYHIKLLHOPOB-UHFFFAOYSA-N [Si][Au][Pt] Chemical compound [Si][Au][Pt] JLHYHIKLLHOPOB-UHFFFAOYSA-N 0.000 claims 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
- 239000000499 gel Substances 0.000 abstract description 38
- 210000004556 brain Anatomy 0.000 abstract description 13
- 210000003710 cerebral cortex Anatomy 0.000 abstract description 11
- 210000005013 brain tissue Anatomy 0.000 abstract description 7
- 238000000034 method Methods 0.000 abstract description 4
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- 241000699666 Mus <mouse, genus> Species 0.000 description 7
- 150000002500 ions Chemical class 0.000 description 7
- 239000000463 material Substances 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 125000005626 carbonium group Chemical group 0.000 description 3
- 125000004386 diacrylate group Chemical group 0.000 description 3
- 239000003999 initiator Substances 0.000 description 3
- 229920002521 macromolecule Polymers 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 210000004958 brain cell Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000001037 epileptic effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 210000005257 cortical tissue Anatomy 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 238000011532 immunohistochemical staining Methods 0.000 description 1
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- 239000007769 metal material Substances 0.000 description 1
- 210000004498 neuroglial cell Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- -1 radical siloxane Chemical class 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
- A61B5/293—Invasive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
Abstract
The invention discloses a kind of application of hydrogel in the electrode for preparing detection electrocorticogram, and what the present invention initiated has used electrocorticogram acquisition technique of the gel of low electric conductivity energy as electrode.The gel realizes conduction in brain liquid environment, by its free ion, and the displacement of ion forms electric current, reached the Detection results that can be compared favourably with high conductive material.Meanwhile gel can form fabulous mechanical property with brain tissue and match, and can be brought into close contact cerebral cortex.Its fabulous biocompatibility can avoid biological rejection.This method not only greatly improves the physiological of traditional electrocorticogram, and is expected to realize long-term electrocorticogram record, more multi-functional to realize.
Description
Technical field
The present invention relates to the application of the hydrogel of low electric conductivity energy, more particularly to a kind of hydrogel to prepare detection cortex
Application in the electrode of electrograph.
Background technology
Electrocorticogram is technological means essential in the Montreal course for the treatment of (being used for the epilepsy for treating patient with severe symptoms).
It is used for determining the cortical region for producing epileptic attack by recording electroencephalogram electrocortical potential.Again by performing the operation this cortical region
Excision, so as to which epileptic attack source be removed.Generally, it is considered that the weak output signal of brain cell granting, those skilled in the art are usual
Using detecting electrode of the metal material with high conduction performance as brain signal.But metal electrode have high hardness and compared with
The biocompatibility of difference, and the conductivity principle different from brain (brain is ionic conduction and metal is electronic conduction).Using
During, metal electrode is easily damaged brain tissue and can not be brought into close contact cerebral cortex.Further, since metal electrode is poor
Biocompatibility and the conductivity principle different from brain, it can not realize long-term in body record.
The content of the invention
In order to overcome the above-mentioned problems of the prior art, the present invention overcomes technology prejudice, there is provided a kind of hydrogel is being made
Application in the electrode of standby detection electrocorticogram.Pioneering has used electrocorticogram acquisition technique of the gel as electrode.
Because the conductivity principle of gel and brain tissue is all ionic conduction, therefore even if the electric conductivity of gel than relatively low, still can be with
The ion concentration difference of brain is transmitted to outside.The head of gel electrode directly contacts with cerebral cortex, rear portion and external collection
Electrode metal silk be connected.Gel is wrapped in flexible dielectric, plays protection and insulating effect.Profit in this way,
Cerebral cortex only with gel and dielectric material joint.The modulus of elasticity of gel is very low and adjustable, can be with brain tissue
Form fabulous mechanical property matching.Soft gel can be brought into close contact cerebral cortex.Gel is as traditional cell culture
Material, there is fabulous biocompatibility.This method not only greatly improves the physiological of traditional electrocorticogram, and
It is expected to realize long-term electrocorticogram record, it is more multi-functional to realize.
To reach above-mentioned purpose, the technical solution adopted in the present invention is：A kind of hydrogel is preparing detection cortex electricity
Application in the electrode of figure, the hydrogel are modulus of elasticity less than 100MPa and the hydrogel of bio-compatible.
Further, the hydrogel is the water-setting being polymerized by the high polymer monomer being dissolved in bio-compatible liquid
Glue.
Further, the bio-compatible liquid is cerebrospinal fluid or physiological saline.
Further, the high polymer monomer is esters, alcohols, amide-type or organic salt.
Further, the high polymer monomer is by PAA, acrylic acid, hydroxyethyl methacrylate, metering system sulphur
One or more in sour sodium, DMAA, vinyl alcohol, ethylene glycol, SSS are polymerized.
Further, the electrode is including the flexible substrates being made up of dielectric material, the gel film made of hydrogel, with
And the inert metal piece in flexible substrates, the gel film are arranged on flexible substrates surface, the electric signal of gel film collection
Exported by inert metal piece.
Further, in addition to it is used for the interface for connecting external instrument, the interface is connected with inert metal piece.
Further, the flexible substrates are made up of dimethyl silicone polymer or platinum silica gel.
Further, the inert metal piece is platinum, gold, silver piece, or has platinum, gold, the sheet metal of silvering.
Further, the gel film is arranged as m*n array, and wherein m, n is positive integer.
The operation principle of electrocorticogram flexible electrode using gel described above is：
Gel film directly contacts with cortex.Cortex excitement leads to the carbonium outside brain cell by ion on cell
Road is pumped into the reduction for into the cell, causing extracellular ion concentration, causes the carbonium in gel film to be oriented to cortex direction and moves
It is dynamic.Carbonium can tail off in the contact portion in gel film and inert metal piece, and negative ion quantity is constant, inert metal
The part that piece contacts with gel film just generates induced potential, and is transmitted to external instrument via external instrument joint.
Compared to the prior art compared with, the invention has the advantages that：
1st, gel electrode has extremely low modulus of elasticity, and can carry out modulus of elasticity by changing the degree of cross linking of gel
Adjustment, be allowed to identical with the modulus of elasticity of brain cortical tissue.Therefore, compared to the metal electrode of conventional solid, gel electricity
The mechanical property of pole more matches with brain tissue, during cerebral cortex tracer signal is bonded, can reduce to brain skin
The damage of layer.
2nd, brain cortex surface and out-of-flatness, be covered with ditch thereon and return, and in cortical field potential measurement, it is desirable to electrode with it is big
Cortex realizes fitting well.Because gel electrode has an extremely low modulus of elasticity, therefore compared to traditional metal electrode,
Gel can preferably be bonded cerebral cortex, realize that field potential records.
3rd, gel is the macromolecule network of solid, therebetween hydraulically full environment.This molecule is formed and biological tissue's class
Seemingly.As traditional tissue cultures material, gel has good biocompatibility.By using neutral gel macromolecule network
Plus cerebrospinal fluid, gel electrode can be supplied to when being bonded cerebral cortex cerebral cortex cells close to script state Breakup of Liquid Ring
Border.Therefore compared to traditional metal electrodes, there is splendid biocompatibility, the production of cerebral cortex spongiocyte can be reduced
It is raw.
4th, gel is the macromolecule network of solid, therebetween hydraulically full environment.Gel by liquid environment dissociate
Ion is realized conductive.Due to being contacted with cortex, during conducted signal, gel has conducted the movement of ion, does not relate to
And electric signal is by the conversion of ion to electronics, therefore the faint gel of electric conductivity has the detection to be compared favourably with high conductive material
Effect.
Brief description of the drawings
Fig. 1, Fig. 2 be electrocorticogram gel electrode of the present invention structural representation top view, front view.
Fig. 3 be heeling-in electrocorticogram gel electrode after mouse cortex two weeks, mouse cortex field that electrode recorded
Current potential；
Fig. 4 is the ImmunohistochemistryResults Results after two weeks in gel and platinum heeling-in such as mouse brain；
Fig. 5 is the stress-strain diagram of gel；
In figure, gel film 1, flexible substrates 2, sheet metal 3, external instrument joint 4.
Embodiment
The present invention is described in further detail with reference to the accompanying drawings and detailed description.
Embodiment 1
Polyethyleneglycol diacrylate is dissolved in cerebrospinal fluid, initiator is added and gel film 1 is made, it is embedded by poly- diformazan
In flexible substrates 2 made of radical siloxane, it is brought into close contact with setting the inert metal piece 3 made of silver strip in advance, inertia gold
Category piece 3 is connected with external instrument joint 4.It is as shown in Figure 1 that flexible electrode is made.
Above-mentioned electrode is placed in mouse (strain C57) encephalic, after 3 time-of-weeks, connects external instrument detector cortex
Field potential, it is as shown in Figure 3 to obtain field potential signal.
By the analysis to field potential it can be found that field potential is regained consciousness evident from mouse has been gone out, the different work such as sleep
Dynamic state, is experimentally confirmed, and the electrode is still available after 2 weeks in Mice Body, has good biocompatibility.It is and general
Time of the electrocorticogram electrode heeling-in in human body is 2 weeks, illustrates the practicality of the electrode.
Embodiment 2
Polyethyleneglycol diacrylate is dissolved in cerebrospinal fluid, initiator is added and gel is made, and gel squeezed into small
Mouse (strain C57) intracerebral.The filamentary material of material platinum used in traditional electrocorticogram electrode is inserted into same mouse intracerebral.
Immunohistochemical staining was carried out after 2 weeks, observes glial cells hyperplasia.As shown in figure 4, left figure is gel, right figure is wire.
Spongiocyte goes out fluorescence by laser excitation under the microscope.It can be found that the spongiocyte of gel is considerably less than the colloid of platinum wire
Cell.Illustrate that gel has good biocompatibility in brain environment.
Embodiment 3
Polyethyleneglycol diacrylate is dissolved in cerebrospinal fluid, initiator is added and gel is made.Measured with stretching-machine solidifying
The stress-strain diagram of glue is as shown in figure 5, it is 200Kpa that can obtain its modulus of elasticity, and traditional metal electrode its springform
Measure in 100Gpa magnitudes, the modulus of elasticity of brain tissue is 10Kpa.This experiment proves the modulus of elasticity of gel and brain tissue more
Match somebody with somebody, damage is smaller relative to metal electrode to caused by brain when being contacted with brain.
Embodiment described above, only inventing, but the protection domain invented is not limited thereto, hydrogel etc.
Material be not limited to exemplary types listed by applicant, according to the actually detected needs of patient, the gel film number of electrode
Amount and position can be adjusted flexibly, its corresponding inert metal piece also can according to the arrangement relative set of electrode gel piece, it is any not
The change or replacement expected by creative work, it should all cover within the protection domain of invention.
Claims (10)
1. a kind of application of hydrogel in the electrode for preparing detection electrocorticogram, the hydrogel are less than for modulus of elasticity
100MPa and bio-compatible hydrogel.
2. application according to claim 1, it is characterised in that：The hydrogel is the height by being dissolved in bio-compatible liquid
The hydrogel that molecule monomer is polymerized.
3. application according to claim 2, it is characterised in that：The bio-compatible liquid is cerebrospinal fluid or physiological saline.
4. application according to claim 2, it is characterised in that：The high polymer monomer is esters, alcohols, amide-type or had
Machine salt.
5. application according to claim 4, it is characterised in that：The high polymer monomer is by PAA, acrylic acid, methyl
One kind in hydroxy-ethyl acrylate, methylpropene sodium sulfonate, DMAA, vinyl alcohol, ethylene glycol, SSS
Or a variety of it is polymerized.
6. application according to claim 1, it is characterised in that：The electrode includes the flexible substrates being made up of dielectric material
(2), gel film (1) made of hydrogel, and the inert metal piece (3) in flexible substrates, the gel film (1) set
Put and corresponded in flexible substrates (2) surface, gel film (1) with inert metal piece (3), the electric signal of gel film (1) collection leads to
Cross inert metal piece (3) output.
7. application according to claim 6, it is characterised in that：Also include being used for the interface (4) for connecting external instrument, it is described
Interface (4) is connected with inert metal piece (3).
8. application according to claim 6, it is characterised in that：The flexible substrates (2) are by dimethyl silicone polymer or platinum
Gold silicon glue is made.
9. application according to claim 6, it is characterised in that：The inert metal piece (3) is platinum, gold, silver piece, or is had
There is platinum, gold, the sheet metal of silvering.
10. application according to claim 6, it is characterised in that：The gel film (1) is arranged as m*n array, wherein m,
N is positive integer.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710806112.XA CN107638176B (en) | 2017-09-08 | 2017-09-08 | Application of hydrogel in preparation of electrode for detecting electroencephalogram of cerebral cortex |
| PCT/CN2017/102849 WO2019047282A1 (en) | 2017-09-08 | 2017-09-22 | Use of hydrogel in preparation of electrode for detecting electrocorticography |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710806112.XA CN107638176B (en) | 2017-09-08 | 2017-09-08 | Application of hydrogel in preparation of electrode for detecting electroencephalogram of cerebral cortex |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107638176A true CN107638176A (en) | 2018-01-30 |
| CN107638176B CN107638176B (en) | 2020-05-08 |
Family
ID=61111042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710806112.XA Active CN107638176B (en) | 2017-09-08 | 2017-09-08 | Application of hydrogel in preparation of electrode for detecting electroencephalogram of cerebral cortex |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN107638176B (en) |
| WO (1) | WO2019047282A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109620539A (en) * | 2018-10-31 | 2019-04-16 | 北京大学 | A kind of device and method that visual information is directly inputted to brain visual cortex |
| CN113057637A (en) * | 2021-03-08 | 2021-07-02 | 电子科技大学 | Hydrogel-based flexible bioelectrode array and manufacturing method thereof |
| CN113583263A (en) * | 2021-08-31 | 2021-11-02 | 中山优感科技有限公司 | High-strength graphene oxide nano composite hydrogel brain electrode and preparation method thereof |
| CN116763318A (en) * | 2023-08-24 | 2023-09-19 | 北京脑科学与类脑研究中心 | Gel layer and implanted flexible brain-computer interface electrode with same |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117224129B (en) * | 2023-11-15 | 2024-03-26 | 之江实验室 | Electrode, preparation method and application thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109620539A (en) * | 2018-10-31 | 2019-04-16 | 北京大学 | A kind of device and method that visual information is directly inputted to brain visual cortex |
| CN113057637A (en) * | 2021-03-08 | 2021-07-02 | 电子科技大学 | Hydrogel-based flexible bioelectrode array and manufacturing method thereof |
| CN113583263A (en) * | 2021-08-31 | 2021-11-02 | 中山优感科技有限公司 | High-strength graphene oxide nano composite hydrogel brain electrode and preparation method thereof |
| CN113583263B (en) * | 2021-08-31 | 2023-12-19 | 中山优感科技有限公司 | High-strength graphene oxide nano composite hydrogel brain electrode and preparation method thereof |
| CN116763318A (en) * | 2023-08-24 | 2023-09-19 | 北京脑科学与类脑研究中心 | Gel layer and implanted flexible brain-computer interface electrode with same |
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| WO2019047282A1 (en) | 2019-03-14 |
| CN107638176B (en) | 2020-05-08 |
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