CN107625894A - A kind of preparation method of compound ginseng stilbene dispersible tablet - Google Patents
A kind of preparation method of compound ginseng stilbene dispersible tablet Download PDFInfo
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Abstract
The invention provides a kind of preparation method of compound ginseng stilbene dispersible tablet, including ginseng, the Radix Astragali, cassia seed, prepared rhizome of rehmannia, rhizoma Gastrodiae, the taste Chinese medicine of rhizoma alismatis 6 to join stilbene dry extract powder through compound made from water extract-alcohol precipitation, vacuum drying；Stilbene dry extract powder and kushenin are joined using compound and prepare compound ginseng stilbene dispersible tablet as raw material.The present invention creatively uses method of the Stepanol MG as surfactant assisted extraction in extraction step；The premix of pregelatinized starch, three kinds of microcrystalline cellulose, lactose auxiliary materials is creatively selected to join the diluent of stilbene dispersible tablet as compound；Creatively from PVPP, two kinds of auxiliary materials of low-substituted hydroxypropyl cellulose premix as compound join stilbene dispersible tablet disintegrant；Creatively join the lubricant of stilbene dispersible tablet as compound from the premix powder of superfine silica gel powder and Macrogol 4000；Flavouring protein sugar powder has creatively been dissolved in the ethanol solution of PVP K30.
Description
Technical field
The present invention relates to pharmaceutical technology field, and in particular to a kind of preparation method of compound ginseng stilbene dispersible tablet.
Background technology
Modern pharmacological research reports that ginseng can increase the nonspecific resistance of body, to various adverse factors, such as physics
, chemical, biological harmful effect can increase the resistance of body；Ginseng can significantly extend mouse swimming it is lasting when
Between, the death rate of the mouse under high temperature, low temperature, low pressure state can be significantly reduced, has and promotes dog to be got well from critically ill state
Effect；Ginseng still has the function that to strengthen immunologic function.In addition ginseng also has the sedation of central nervous system；Also
The effect of similar cardiac glycoside；Promote the effect of adrenal cortex function；Hypoglycemic effect；The content rise of hematopoietin
Effect etc., ginseng can promote the division of myeloid element, make the content of leucocyte in peripheral blood, red blood cell and hemoglobin
Increase, improve the immunologic function of the elderly, strengthen body antiserum shock, mitigate the fatigue and hypomnesia of the elderly.
Modern pharmacological research reports that the Radix Astragali can stimulate myelosis, improve the secretion of Hemopoietic factor；The Radix Astragali also has enhancing
Immunologic function, extend the effect of cell body survival；Astragalus polyose can dramatically increase the phagocytosis of mouse macrophage；Improve empty
Spot forms haematolysis ability and the effect of obvious carbon particle clearance of cell；There is obvious antitumor, anti-aging；It can strengthen
Mouse is acted on the memory of study and consolidating memory, and has stronger diuresis；There is antivirus action etc..The single Radix Astragali can make
The lymphocyte transformation rate of immunologic hypofunction mouse rises, and IL22 can also be induced to produce when dosage is appropriate.In addition, the Radix Astragali is in body
Inside also there is the partial function for promoting Th1 and Th2 cells, so as to improve the jejune immune state of body.The Radix Astragali can promote carefully
The increase of intracellular CAMP contents, so as to promote the synthesis of bone marrow cell DNA and protein, accelerate point of karyocyte
Split.
Kushenin is the mixed base of oxymatrine and very small amount N-Oxysophocarpine, and modern pharmacological research shows that kushenin has
Numerous pharmacological actions：It is such as antiviral；Induce endogenous interferon；Liver cell is protected, improves liver function；Anti-hepatic fibrosis；Rise
Leucocyte；It is antitumor etc..
Rhizoma Gastrodiae has humidification to the cellular immunity in mouse nospecific immunity and specific immunity and humoral immunity,
In addition still there is obvious analgesic activity etc..
Prepared rhizome of rehmannia water extraction liquid energy dramatically increases peripheral blood in mice T lymphocytes.
Rhizoma alismatis plays the role of diuresis, reducing blood lipid, anti-fatty liver, increase coronary flow, reduction blood glucose；Rhizoma alismatis has stronger
Anti-malignant tumor transferance.
Cassia seed has inhibitory action to immune function of mice, can strengthen the phagocytic function of macrophage.
This product is the principle prescription treatinged deficiency with tonification according to traditional Chinese medicine, and ginseng, the Radix Astragali reinforce vital energy in side, qi and blood can be promoted to give birth to
Changing, improve the immunity of body, people participates in the Radix Astragali and shares its tonifying Qi effect more preferably, replenished qi to invigorate the spleen with reaching, regulating yin and yang, entangle
Positive negative and positive, the pathological phenomenon contained, declined partially partially, recover or improve the function of internal organs；Prepared rhizome of rehmannia Zishen fill fine；Rhizoma alismatis diuresis is without hindering
Sun.This product, which has reached the traditional Chinese medical science, which strengthens the body resistance to consolidate the constitution, strengthens the purpose of resistance against diseases, while compensate for simple western medicine in the treatment and treat it
Deficiency, embody the advantage of the combination of Chinese tradiational and Western medicine.
The treatment of cancer is based on Radiotherapy chemotherapy, in order to improve the survival rate of cancer patient and reduce DISTANT METASTASES IN, Radiotherapy chemotherapy
Complex treatment is currently to III phase, the primary treatment scheme of IV a phase cancers.But during Radiotherapy chemotherapy, bone marrow suppression is most normal
The side effect seen, it not only influences complex treatment and is smoothed out but also the raising that affects the treatment.After cancer radiation starts, the radiotherapy time
It is close with therapeutic effect relationship, stop one week, curative effect declines 10%~15%, so ensureing that smoothly completing for radiotherapy is particularly significant.Otherwise,
Radiotherapy effect can be had a strong impact on.At present, can cause in most of antineoplastics and the chemotherapy process of tumour different degrees of
Bone marrow suppression, be that many tumor patients can not smoothly complete chemotherapy cycles, even result in interrupt treatment one of major reason this
Often lead to treatment to interrupt, directly affects effect of the chemotherapeutics to oncotherapy.Cancer patient is in chemotherapy with chemotherapeutic
Thing cumulant increase in vivo, its side reaction are mainly shown as that bone marrow suppression, gastrointestinal dysfunction, immunologic function reduce.Therefrom
Doctor's angle says predominantly qi and blood damage, taste imbalance, liver-kidney deficiency, therefore in treating based on righting help, i.e. benefiting qi and nourishing blood, strong
Spleen and stomach, nourishing kidney essence.Benefiting qi for promoting production of blood medicine can strengthen immunologic function, improve body resistance against diseases, promote the conjunction of RNA and protein
Into having certain stimulation to hemopoietic system to embody its function.Kidney-nourishing tcm drug, which also has, promotes hematopoietic cell proliferation effect, also shadow
Marrow stromal cell is rung, experiment proves that recovery of the nourishing kidney essence to bone marrow suppression has positive role.Due to tumour cell and just
Lack the metabolic disorder of essence between normal cell, therefore most of cancer therapy drugs can not still be kept away while tumour cell is killed
Exempt from the infringement to normal cell, it is bigger especially to breed the infringement that faster haemocyte is subject to, so as caused by chemotherapeutics
Marrow hemopoiesis suppresses the serious dosage and frequency for limiting chemotherapy, influences being smoothed out and restricting its therapeutic effect for chemotherapy.Cause
This, in the market very demand curative effect is high, price is honest and clean, Small side effects raising immunity of organisms, the medicine of increasing leukocyte.
Dispersible tablet is a kind of solid pharmaceutical preparation, both orally available, is also dispersible in water and is taken as solution, especially to swallowing
Difficult children and old man are more convenient.Dispersible tablet have convenient oral, disintegration time are short, be uniformly dispersed, drug-eluting is rapid,
Absorb the advantages that fast, bioavilability is high, adverse reaction is small.
The content of the invention
In view of this, it is an object of the invention to provide a kind of preparation method of compound ginseng stilbene dispersible tablet, including following step
Suddenly：
1）To ginseng, the Radix Astragali, cassia seed, prepared rhizome of rehmannia, rhizoma Gastrodiae, the taste Chinese medicine of rhizoma alismatis 6 in the presence of surfactants through water extracting alcohol
It is heavy to obtain extraction immersion liquid, obtain compound ginseng stilbene dry extract powder by being dried in vacuo；
2）Stilbene dry extract powder and kushenin powder are joined as raw material using compound, add the premix of diluent, partial disintegration agent
Premix, pelletized by adhesive of the ethanol solution of PVP K30；
3）The dry particl of compound ginseng stilbene dispersible tablet is well mixed with partial disintegration agent premix and lubricant premix, tabletting,
Prepare compound ginseng stilbene dispersible tablet.
Preferably, in the preparation method of compound ginseng stilbene dispersible tablet of the present invention, the step 1）In 6 taste Chinese medicines carry
Take, carry out by the following method：Weigh ginseng 380g, Radix Astragali 310g, cassia seed 180g, prepared rhizome of rehmannia 180g, rhizoma Gastrodiae 90g, rhizoma alismatis
130g is placed in extractor, is added 3.81g surfactants and is added the Extraction solvent of 10 times of crude drug amounts, extraction 2 times, every time
2h, filtering, merging filtrate, filtrate decompression are concentrated into relative density as 1.20~1.25（60~65 DEG C）Clear cream, add ethanol to make
Alcohol content stands 24h, filtering, filtrate decompression concentration and recovery ethanol, is concentrated into relative density as 1.20~1.25 up to 70%（60~
65℃）Clear cream, be dried in vacuo into dry extract, above-mentioned dry extract crushed, cross 80~100 mesh sieves, obtain the dry leaching of compound ginseng stilbene
Cream powder；It is highly preferred that the Extraction solvent is water, refluxing extraction number is 2 times, and each extraction time is respectively 2,2h；More
Preferably, surfactant is Stepanol MG, and its dosage is the 0.3% of 6 taste Chinese medicine gross masses.
Preferably, in the preparation method of compound ginseng stilbene dispersible tablet of the present invention, the step 2）Middle compound ginseng stilbene disperses
The method of granulating of piece is wet granulation.
It is highly preferred that the step 2）Middle pelletization is as follows：By kushenin, diluents microcrystalline cellulose, pregelatinated form sediment
Powder, lactose, disintegrant PVPP, low-substituted hydroxypropyl cellulose, flavouring protein sugar, lubricant polyethylene glycol
4000, polyvinyl pyrrolidone K30 are crushed, and cross 80~100 mesh sieves, standby；Then compound ginseng stilbene dry extract and hardship are taken
Join plain powder, add premix, the premix of disintegrant of diluent, mix, added dissolved with protein sugar powder in container
The ethanol solution of 10% PVP K30, softwood processed, softwood are pelletized with 24 mesh sieves, and wet granular is dried under the conditions of 60 DEG C
Dry, prepare the dry particl of compound ginseng stilbene dispersible tablet.
Preferably, in the preparation method of compound ginseng stilbene dispersible tablet of the present invention, the step 2）In prepare it is dilute during particle
It is respectively 2 according to mass ratio that the premix of agent, which is released, as pregelatinized starch, microcrystalline cellulose, lactose powder：1：1,2：2：1 and 2：1：
2 mixture；The premix of disintegrant is PVPP, low-substituted hydroxypropyl cellulose powder according to quality score
Wei 1：1,1：2 and 2：1 mixture；Adhesive is molten for the ethanol of 10% PVP K30 dissolved with protein sugar powder
Liquid.
Preferably, in the preparation method of compound ginseng stilbene dispersible tablet of the present invention, the step 2）In prepare it is dilute during particle
The dosage of agent premix is released, with 1000 for radix, its dosage is 165~172g；The dosage of disintegrant premix, with 1000
For radix, its dosage is 30g.
Preferably, in the preparation method of compound ginseng stilbene dispersible tablet of the present invention, the step 3）Middle mixed process is as follows：
It is standby with 24 mesh sieve whole grains by dried particle；It is 2 in mass ratio by Macrogol 4000 powder and superfine silica gel powder powder：1
It is well mixed, the premix of lubricant is prepared, it is standby；Disintegrant premix 20g and 6g lubricant premix is used into equivalent again
Mixing method of progressively increasing is well mixed；Finally above-mentioned powder and the particle after whole grain are well mixed using equivalent mixing method of progressively increasing again,
Tabletting, produce compound ginseng stilbene dispersible tablet.
Compared with prior art, the present invention has advantages below to the present invention：The present invention creatively makes in extraction step
Method by the use of Stepanol MG as surfactant assisted extraction；The present invention creatively prepare compound ginseng stilbene disperse
Premix during piece from pregelatinized starch, three kinds of microcrystalline cellulose, lactose auxiliary materials is diluent；The present invention is creatively making
It is for premix during compound ginseng stilbene dispersible tablet from two kinds of PVPP, low-substituted hydroxypropyl cellulose auxiliary materials
Disintegrant；The present invention is creatively when preparing compound ginseng stilbene dispersible tablet from the premix of Macrogol 4000 and superfine silica gel powder
Powder is lubricant；The present invention has creatively dissolved in flavouring albumen Icing Sugar in the ethanol solution of adhesive PVP K30
End.And obtain compound ginseng stilbene dispersible tablet in good taste, that disintegration is rapid, easy to carry.
Embodiment
A kind of preparation method of compound ginseng stilbene dispersible tablet is provided in embodiments of the invention, is comprised the following steps：
1）To ginseng, the Radix Astragali, cassia seed, prepared rhizome of rehmannia, rhizoma Gastrodiae, the taste Chinese medicine of rhizoma alismatis 6 in the presence of surfactants through water extracting alcohol
It is heavy to obtain extraction immersion liquid, obtain compound ginseng stilbene dry extract powder by being dried in vacuo；
2）Stilbene dry extract powder and kushenin powder are joined as raw material using compound, add the premix of diluent, partial disintegration agent
Premix, pelletized by adhesive of the ethanol solution of PVP K30；
3）The dry particl of compound ginseng stilbene dispersible tablet is well mixed with partial disintegration agent premix and lubricant premix, tabletting,
Prepare compound ginseng stilbene dispersible tablet.
Preferably, in the preparation method of compound ginseng stilbene dispersible tablet of the present invention, the step 1）In 6 taste Chinese medicines carry
Take, carry out by the following method：Weigh ginseng 380g, Radix Astragali 310g, cassia seed 180g, prepared rhizome of rehmannia 180g, rhizoma Gastrodiae 90g, rhizoma alismatis
130g is placed in extractor, is added 3.81g Stepanol MGs and is added 12.7L water, heating and refluxing extraction 2h, filtering,
Filtrate is standby；Residue adds 12.7L water refluxing extraction 2h, filtering, merges 2 filtrates, under the conditions of 60~65 DEG C, filtrate subtracts
Pressure is concentrated into the clear cream that relative density is 1.20~1.25, adds ethanol alcohol content is stood 24h, filtering, filtrate decompression up to 70%
Concentration and recovery ethanol, under the conditions of 60~65 DEG C, the clear cream that relative density is 1.20~1.25 is concentrated into, be dried in vacuo into dry
Medicinal extract, above-mentioned dry extract is crushed, cross 80~100 mesh sieves, obtain compound ginseng stilbene dry extract powder；It is highly preferred that surface-active
The dosage of agent Stepanol MG is the 0.3% of 6 taste Chinese medicine gross masses.
Preferably, in the preparation method of compound ginseng stilbene dispersible tablet of the present invention, the step 2）Middle compound ginseng stilbene disperses
The method of granulating of piece is wet granulation.
It is highly preferred that the step 2）Middle pelletization is as follows：By kushenin, diluents microcrystalline cellulose, pregelatinated form sediment
Powder, lactose, disintegrant PVPP, low-substituted hydroxypropyl cellulose, flavouring protein sugar, lubricant polyethylene glycol
4000, polyvinyl pyrrolidone K30 are crushed, and cross 80~100 mesh sieves, standby；Then compound ginseng stilbene dry extract and hardship are taken
Join plain powder, add premix, the premix of disintegrant of diluent, mix, added dissolved with protein sugar powder in container
The ethanol solution of 10% PVP K30, softwood processed, softwood are pelletized with 24 mesh sieves, and wet granular dries under the conditions of 60 DEG C
It is dry, prepare the dry particl of compound ginseng stilbene dispersible tablet.
Preferably, in the preparation method of compound ginseng stilbene dispersible tablet of the present invention, the step 2）In prepare it is dilute during particle
It is respectively 2 according to mass ratio that the premix of agent, which is released, as pregelatinized starch, microcrystalline cellulose, lactose powder：1：1,2：2：1 and 2：1：
2 mixture；The premix of disintegrant is PVPP, low-substituted hydroxypropyl cellulose powder according to quality score
Wei 1：1,1：2 and 2：1 mixture；Adhesive is molten for the ethanol of 10% PVP K30 dissolved with protein sugar powder
Liquid.
Preferably, in the preparation method of compound ginseng stilbene dispersible tablet of the present invention, the step 2）In prepare it is dilute during particle
The dosage of agent premix is released, with 1000 for radix, its dosage is 165~172g；The dosage of disintegrant premix, with 1000
For radix, its dosage is 30g.
Preferably, in the preparation method of compound ginseng stilbene dispersible tablet of the present invention, the step 3）Middle mixed process is as follows：
It is standby with 24 mesh sieve whole grains by dried particle；It is 2 in mass ratio by Macrogol 4000 powder and superfine silica gel powder powder：1
It is well mixed, the premix of lubricant is prepared, it is standby；Disintegrant premix 20g and 6g lubricant premix is used into equivalent again
Mixing method of progressively increasing is well mixed；Finally above-mentioned powder and the particle after whole grain are well mixed using equivalent mixing method of progressively increasing again,
Tabletting, produce compound ginseng stilbene dispersible tablet.
Below in conjunction with the embodiment in the present invention, the technical scheme in the present invention is clearly and completely described.It is aobvious
So, described embodiment is only part of the embodiment of the present invention, rather than whole embodiments.Based on the reality in the present invention
Example is applied, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, is all belonged to
In the scope of protection of the invention.
Embodiment 1：Compound joins the preparation of stilbene dispersible tablet
1st, the preparation process of compound ginseng stilbene dry extract：Weigh ginseng 380g, Radix Astragali 310g, cassia seed 180g, prepared rhizome of rehmannia 180g, day
Numb 90g, rhizoma alismatis 130g are placed in extractor, are added 3.81g Stepanol MGs and are added 12.7L water, are heated to reflux carrying
2h is taken, is filtered, filtrate is standby；Residue adds 12.7L water refluxing extraction 2h, filtering, merges 2 filtrates, in 60~65 DEG C of bars
Under part, filtrate decompression is concentrated into the clear cream that relative density is 1.20~1.25, adds ethanol alcohol content is stood 24h, mistake up to 70%
Filter, filtrate decompression concentration and recovery ethanol, under the conditions of 60~65 DEG C, the clear cream that relative density is 1.20~1.25 is concentrated into, very
Sky is dried to dry extract, and above-mentioned dry extract is crushed, and crosses 80~100 mesh sieves, standby, obtains compound ginseng stilbene dry extract powder, its
Quality is 132g；
2nd, by kushenin, diluents microcrystalline cellulose, pregelatinized starch, lactose, disintegrant PVPP, low take
Crushed for hydroxypropylcellulose, flavouring protein sugar, lubricant Macrogol 4000, polyvinyl pyrrolidone K30, cross 80
~100 mesh sieves, it is standby；
3rd, it is 2 according to mass ratio by the microcrystalline cellulose, pregelatinized starch, lactose powder of crossing 80~100 mesh sieves：1：2 mixing are equal
It is even, prepare the premix of diluent；PVPP, the low-substituted hydroxypropyl cellulose powder of 80~100 mesh sieves will be crossed
End is 2 according to weight ratio：1 is well mixed, prepares the premix of disintegrant；By recipe quantity, every 1000 are radix, take step 1
Compound ginseng stilbene dry extract powder 132g and kushenin powder 50g, the premix 168g of diluent, the premix 30g of disintegrant, will
Above-mentioned material mixes in mixer, adds the ethanol solution of 10% PVP K30 dissolved with protein sugar powder, uses
High-speed granulator or oscillating granulator softwood, softwood are pelletized with 24 mesh sieves, and wet granular dries drying under the conditions of 60 DEG C；
4th, it is standby with 24 mesh sieve whole grains after wet granular is dried；By Macrogol 4000 powder and superfine silica gel powder powder in mass ratio
For 2：1 is well mixed, prepares the premix of lubricant, standby；The premix of disintegrant premix 20g and 6g lubricant is used again
Equivalent mixing method of progressively increasing is well mixed；Finally above-mentioned powder and the particle after whole grain are mixed using equivalent mixing method of progressively increasing again
It is even, tabletting, compound ginseng stilbene dispersible tablet is produced, the dispersible tablet is checked according to the disintegration time limited inspection technique of 2015 editions Chinese Pharmacopoeias one
Disintegration time limited be 2.2min.
Claims (9)
1. a kind of preparation method of compound ginseng stilbene dispersible tablet, comprises the following steps：
1）To ginseng, the Radix Astragali, cassia seed, prepared rhizome of rehmannia, rhizoma Gastrodiae, the taste Chinese medicine of rhizoma alismatis 6 in the presence of surfactants through water extracting alcohol
It is heavy to obtain extraction immersion liquid, obtain compound ginseng stilbene dry extract powder by being dried in vacuo；
2）Stilbene dry extract powder and kushenin powder are joined as raw material using compound, add the premix of diluent, partial disintegration agent
Premix, pelletized by adhesive of the ethanol solution of PVP K30；
3）The dry particl of compound ginseng stilbene dispersible tablet is well mixed with partial disintegration agent premix and lubricant premix, tabletting,
Prepare compound ginseng stilbene dispersible tablet.
2. according to the method for claim 1, it is characterised in that the step 1）In 6 taste Chinese medicines extraction, by following
Method is carried out：Weigh ginseng 380g, Radix Astragali 310g, cassia seed 180g, prepared rhizome of rehmannia 180g, rhizoma Gastrodiae 90g, rhizoma alismatis 130g and be placed in extraction
In device, add 3.81g surfactants and add the Extraction solvent of 10 times of crude drug amounts, extract 2 times, 2 hours every time, filter, close
And filtrate, filtrate decompression are concentrated into relative density as 1.20~1.25（60~65 DEG C）Clear cream, add ethanol to reach alcohol content
70%, 24 hours are stood, filtering, filtrate decompression concentration and recovery ethanol, it is 1.20~1.25 to be concentrated into relative density（60~65
℃）Clear cream, be dried in vacuo into dry extract, above-mentioned dry extract crushed, cross 80~100 mesh sieves, it is standby, obtain compound ginseng stilbene do
Medicinal extract powder.
3. according to the method for claim 2, it is characterised in that the Extraction solvent is water, and refluxing extraction number is 2 times,
Each extraction time is respectively 2,2 hours, and adds surfactant sodium dodecyl base magnesium sulfate when extracting for the 1st time.
4. according to the method for claim 3, it is characterised in that the addition of the surfactant sodium dodecyl base magnesium sulfate
For the 0.3% of 6 taste Chinese medicine gross masses.
5. according to the method for claim 1, it is characterised in that the step 2）The method of granulating of middle compound ginseng stilbene dispersible tablet
For wet granulation.
6. according to the method for claim 5, it is characterised in that the step 2）Middle wet granulation, enters by the following method
OK：By kushenin, diluents microcrystalline cellulose, pregelatinized starch, lactose, disintegrant PVPP, low substitution
Hydroxypropylcellulose, flavouring protein sugar, lubricant Macrogol 4000, polyvinyl pyrrolidone K30 are crushed, excessively 80~
100 mesh sieves, it is standby；Then compound ginseng stilbene dry extract and kushenin powder are taken, adds premix, the premix of disintegrant of diluent
Material, mixes in container, adds the ethanol solution of 10% PVP K30 dissolved with protein sugar powder, softwood processed is soft
The mesh sieve of timber-used 24 is pelletized, and wet granular dries drying under the conditions of 60 DEG C, prepares the dry particl of compound ginseng stilbene dispersible tablet.
7. according to the method for claim 6, it is characterised in that the step 2）The premix of middle diluent when preparing particle
According to mass ratio it is respectively 2 for pregelatinized starch, microcrystalline cellulose, lactose powder：1：1,2：2：1 and 2：1：2 mixture；Collapse
The premix for solving agent is PVPP, low-substituted hydroxypropyl cellulose powder according to mass ratio is respectively 1：1,1：2
And 2：1 mixture；Adhesive is the ethanol solution dissolved with 10% PVP K30 of protein sugar powder.
8. according to the method for claim 7, it is characterised in that the step 2）Middle diluent premix when preparing particle
Dosage, with 1000 for radix, its dosage is 165~172g；The dosage of disintegrant premix, with 1000 for radix, it is used
Measure as 30g.
9. according to the method for claim 1, it is characterised in that the step 3）Middle mixed process is as follows：Will be dried
Particle, it is standby with 24 mesh sieve whole grains；It is 2 in mass ratio by Macrogol 4000 powder and superfine silica gel powder powder：1 is well mixed,
The premix of lubricant is prepared, it is standby；Disintegrant premix 20g and 6g lubricant premix is progressively increased mixing method using equivalent again
It is well mixed；Finally above-mentioned powder and the particle after whole grain are well mixed using equivalent mixing method of progressively increasing again, tabletting, produces and answers
Side's ginseng stilbene dispersible tablet.
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Application publication date: 20180126 |
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