CN107625516A - A kind of insertion type medical probe of multi-parameter - Google Patents
A kind of insertion type medical probe of multi-parameter Download PDFInfo
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- CN107625516A CN107625516A CN201710783917.7A CN201710783917A CN107625516A CN 107625516 A CN107625516 A CN 107625516A CN 201710783917 A CN201710783917 A CN 201710783917A CN 107625516 A CN107625516 A CN 107625516A
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Abstract
The invention discloses a kind of insertion type medical probe of multi-parameter, including probing shell, temperature-sensing element and other at least one physiological parameter sensing elements；The probing shell, has closing head, and position is monitored for intervening；Its middle part has blind hole, for fitting temperature sensing element；Its side has at least one neck, for assembling other physiological parameter sensing elements；The temperature-sensing element is assemblied in the blind hole；Other described physiological parameter sensing elements are assemblied in the neck.The present invention realizes the real-time measurement for including internal pressure, temperature and a variety of physical signs of oxygen metabolism to human body simultaneously using a miniature probe, and a variety of sensing elements are all located at probe top, and test position is highly consistent；Under this premise, other physiological parameter sensors, such as pressure sensing and partial pressure of oxygen sensing can carry out real-time temperature compensation using temperature sensing data, and applicable scene domain is wide, and practicality and the degree of accuracy are high.
Description
Technical field
The invention belongs to medical instruments field, more particularly, to a kind of insertion type medical probe of multi-parameter.
Background technology
Temperature, pressure, oxygen metabolism are the important physical signs of human body.Realize the reliable prison to a variety of physical signs in human body
Survey will be helpful to diagnose the human body state of an illness, improve the rescued effect of patient.
So that neurosurgical is treated as an example, intracranial hypertension is the postoperative relatively conventional complication of neurosurgical patients, is
Cause the postoperative crucial inducement that sb.'s illness took a turn for the worse of neurosurgical patients.Intracranial pressure power, which increases, can cause brain perfusion drops, very
To hernia cerebri is formed, cause patient disabilities or death.Therefore, continuing to monitor for intracranial pressure becomes neurosurgical patients treatment
Important content.As mild hypothermia therapy method is incorporated among intracranial hypertension treatment, clinically it also is intended to that cranium can be monitored simultaneously
Interior temperature finely controls therapeutic process.In addition, intractable intracranial hypertension Chang Jifa is tight caused by the reason such as severe brain injury
The cerebral hypoxia ischemia of weight changes.Therefore, monitoring treatment of the brain oxygen metabolism situation to patient has great importance.
Clinically often realized with the use of plurality of devices to being measured while patient's multi-parameter, measurement is inconvenient and difficult
To accomplish that multi-parameter continues to monitor.Further, various equipment are unable to cooperating at present, therefore the physical signs measured, come
Come from body different parts, it is impossible to the definite physiological conditions for embodying lesions position.Simultaneously because the fluctuation of physiological environment, especially makes
Body temperature fluctuation so that temperature drift phenomenon occurs in sensor, and measurement accuracy declines to a great extent, and can not accurately monitor the physiology of patient
Parameter.
The content of the invention
For the disadvantages described above or Improvement requirement of prior art, the invention provides a kind of medical spy of the insertion type of multi-parameter
Head, its object is to by a variety of physiological parameter sensors rationally integrate and be encapsulated in the probe of miniaturization, thus solve
Prior art measurement multi-parameter physiology parameter monitoring inconvenience, multi-parameter or inaccurate with point monitoring, monitoring result can not be continued
Technical problem.
To achieve the above object, according to one aspect of the present invention, there is provided a kind of insertion type medical probe of multi-parameter,
Including probing shell, conduit, temperature-sensing element and other at least one physiological parameter sensing elements；
The probing shell, has closing head, and position is monitored for intervening；Its middle part has blind hole, for assembling temperature
Spend sensing element；Its side has at least one neck, for assembling other physiological parameter sensing elements；
The temperature-sensing element is assemblied in the blind hole；
Other described physiological parameter sensing elements are assemblied in the neck.Preferably, the insertion type doctor of the multi-parameter
With probe, it includes temperature compensation means；
The temperature compensation means is connected with temperature-sensing element, other physiological parameter sensing element signals；It is used to connect
The real time temperature of shrinkage temperature sensing element measure, and the measured value of other physiological parameter sensing elements is carried out according to real time temperature
Compensation obtains the real-time measurements of other physiological parameters.
Preferably, the temperature compensation means, including nominal data memory module and data extraction module；
The nominal data memory module is used to store other physiological parameters sensing under each temperature sensor signal
Other physiological parameter numerical tabulars corresponding to element signal；
The data extraction module, for receiving temperature sensor signal and other described physiological parameter sensing elements letter
Number, and other corresponding physiological parameter numerical value are searched as other lifes after compensation in the numerical tabular of data memory module storage
Manage the real-time measurements output of parameter.
The conduit is connected with probing shell rear portion, and its enclosed inside has wire.
Preferably, the insertion type medical probe of the multi-parameter, other physiological parameter sensing elements are pressure sensor,
It is assemblied in the neck of probing shell side, barrier film of the surface covered with shore hardness 10-80A.The work of barrier film
With being the accurate sensing chip of protection, and the selection of its hardness directly affects the sensitivity of pressure sensor.Because the present invention is to be situated between
Enter the medical probe of formula, isolation film hardness need to be sufficiently large, bears to intervene the pressure of measuring environment, another so as to protect sensor
Aspect is contemplated that its sensitivity of pressure sensing.Especially described insertion type medical catheter may be operated in pathological conditions
Under, pressure limit changes greatly, and the hardness parameter of barrier film is most important.Reasonable selection isolation film hardness can both ensure not shadow
Pressure sensing sensitivity is rung, and buffer protection function is played to the sensing chip of precision.
Preferably, the insertion type medical probe of the multi-parameter, other physiological parameter sensing elements are partial pressure of oxygen sensing element
Part includes detection fiber, the detection fiber head be assemblied in for in the neck of probing shell side, the neck covered with
High polymer material with oxygen molecule permeability, preferably silicon rubber.
Preferably, the insertion type medical probe of the multi-parameter, its partial pressure of oxygen sensor include detection fiber and covering institute
The fluorescent film of detection fiber end face is stated, what the fluorescent film had oxygen molecule permeability and can be quenched embedded with its fluorescence by oxygen molecule
Fluorescent dye.
Preferably, the insertion type medical probe of the multi-parameter, its detection fiber end face are angle end face.
Preferably, the insertion type medical probe of the multi-parameter, its partial pressure of oxygen sensing element include exciting light and module occur
It is y-type optical fiber with detection fiber described in Photoelectric Detection module, with laser module and Photoelectric Detection occur for the both ends of its branch respectively
Module is connected.
Preferably, the insertion type medical probe of the multi-parameter, it includes various other physiological parameter sensing elements；It is described
Its side of probing shell has the equally distributed neck of respective numbers.
Preferably, the insertion type medical probe of the multi-parameter, it includes two kinds of other physiological parameter sensing elements, for pressure
Power sensing element and partial pressure of oxygen sensing element.
Preferably, the insertion type medical probe of the multi-parameter, its probing shell are biocompatibility rigid material, preferably
For titanium alloy, titanium or stainless steel.
Preferably, the insertion type medical probe of the multi-parameter, in addition to Signal-regulated kinase and main control module；It is described to swash
Module, Photoelectric Detection module and Signal-regulated kinase occur for light, are all connected with main control module.The Signal-regulated kinase and temperature
Degree sensing element and other sensing elements are connected, for entering row energization and signal to temperature-sensing element and pressure sensor
Conditioning.The main control module, for controlling the laser that the output lighted and obtain corresponding moment conditioning module of module occurs
Signal, so as to which data are acquired and analyzed, show, store and export.The temperature compensation means can be embedded in
In the main control module or a part being individually connected with main control module.
In general, by the contemplated above technical scheme of the present invention compared with prior art, it can obtain down and show
Beneficial effect：
The present invention is realized simultaneously using a miniature probe includes internal pressure, temperature and a variety of lifes of oxygen metabolism to human body
The real-time measurement of index is managed, a variety of sensing elements are all located at probe top, and test position is highly consistent；This premise it
Under, other physiological parameter sensors, such as pressure sensing and partial pressure of oxygen sensing can carry out temperature in real time using temperature sensing data
Degree compensation, applicable scene domain is wide, and practicality and the degree of accuracy are high；Meanwhile top of popping one's head in reaches test position and can detected,
Popped one's head in without long insertion, avoid causing extra tissue damage.
For micro sensing probe, the design processing and the assembling of sensing element of probing shell are technological difficulties.Cause
Big for miniature probe housing difficulty of processing, existing miniature probe does not often have sensing element fixing device, therefore brings probe group
Fill that operation difficulty is big, and validity and uniformity are difficult to ensure that, the problem of yield rate and low production efficiency.Spy provided by the invention
Head, by carrying out sophisticated design to probing shell, corresponding fixed installation structure is all machined with for every kind of sensing element, was assembled
Journey controllability is high, and the uniformity of probe is good；In addition when popping one's head in insertion, sensing element can be protected by probing shell,
Will not be by the pollution and damage of biological tissue.Meanwhile without extra add-on assemble, sonde configuration and simple for assembly process,
Production quality controllability is good.
Preferred scheme, partial pressure of oxygen is detected using fluorescent quenching method, directly mole content of oxygen assessed, no
It can be influenceed by detection other tissues of position, survey reliability in physical examination and Clinical practicability is high.
Brief description of the drawings
Fig. 1 is the cross-sectional view on the insertion type medical probe top of multi-parameter provided in an embodiment of the present invention；Its
A-A directions schematic cross-section is shown in Fig. 2.
Fig. 2 is the sectional view in the insertion type medical probe A-A directions of multi-parameter provided in an embodiment of the present invention；
Fig. 3 is partial pressure of oxygen sensing element schematic diagram provided in an embodiment of the present invention.
In all of the figs, identical reference is used for representing identical element or structure, wherein：1 is probing shell,
2 be the first neck, and 3 be blind hole, and 4 be the second neck, and 5 be tubular structure, and 6 be pressure sensor, and 7 be temperature-sensing element, 8
It is optical fiber mounting hole for detection fiber, 9,10 be conduit, and 11 be wire, and 12 be locating slot, and 13 be fluorescent film.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, it is right below in conjunction with drawings and Examples
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.As long as in addition, technical characteristic involved in each embodiment of invention described below
Conflict can is not formed each other to be mutually combined.
The insertion type medical probe of multi-parameter provided by the invention, including：Probing shell 1, temperature-sensing element 7, at least
A kind of other physiological parameter sensing element, temperature compensation means.
The probing shell 1, has closing head, and position is monitored for intervening；Its middle part has blind hole 3, for assembling
Temperature-sensing element 7；Its side has at least one neck, for assembling other physiological parameter sensing elements；It is preferred that using life
Thing compatibility rigid material, such as titanium alloy, titanium or stainless steel.The front portion of probing shell 1 is semicircle sphere or smaller part
Surface of Sphere, rear portion are tubular structure 5, for such as being led with the accessory of the temperature-sensing element 7, other physiological parameter sensing elements
Pipe 10, wire 11 etc. are assembled.
The temperature-sensing element 7 is assemblied in the blind hole 3；
Other described physiological parameter sensing elements are assemblied in the neck.It is preferred that can be pressure sensor 6, partial pressure of oxygen
Sensing element 8 etc..
The external diameter of affiliated probing shell is 0.8-2.0mm.
When other described physiological parameter sensing elements are pressure sensor 6, the neck plays a part of positioning, its
Barrier film of the surface covered with shore hardness 30A, for further fixation pressure sensing element 6 while conducting pressure.It is described every
From film, it is preferred to use the elastic polymer material such as silicon rubber, gel, latex.The pressure sensor 6 preferably uses absolute pressure
Power sensing element.The gauge pressure sensing element typically used compared to existing pressure sensing probe, the present invention are passed using absolute pressure
Air guide channel need not be designed in sensing unit, probing shell and conduit, reduces the design and producing difficulty of miniature probe, also for
The a variety of sensings of progress are integrated in miniature probe size provides possibility.
When other described physiological parameter sensing elements are partial pressure of oxygen sensing element 8, the neck is detection window.It is described
Neck is covered with the high polymer material with oxygen molecule permeability, preferably silicon rubber.It is preferred that the partial pressure of oxygen sensing element 8 uses
Detection fiber, the detection fiber head are assemblied in neck, and the head end is preferably angle end face.
When the insertion type medical probe of the multi-parameter includes a variety of other physiological parameter sensing elements, the probe shell
Its side of body 1 has the equally distributed neck of respective numbers, for assembling other described physiological parameter sensing elements.
The temperature compensation means is connected with temperature-sensing element 7, other physiological parameter sensing element signals；It is used to connect
The real time temperature that shrinkage temperature sensing element 7 determines, and the measured value of other physiological parameter sensing elements is entered according to real time temperature
Row compensation obtains the real-time measurements of other physiological parameters.
Preferably, the temperature compensation means, including nominal data memory module and data extraction module；
The nominal data memory module is used to store other physiological parameters sensing under each temperature sensor signal
Other physiological parameter numerical tabulars corresponding to element signal；
The data extraction module, for receiving temperature sensor signal and other described physiological parameter sensing elements letter
Number, and other corresponding physiological parameter numerical value are searched as other lifes after compensation in the numerical tabular of data memory module storage
Manage the real-time measurements output of parameter.
Multi-parameter insertion type medical probe provided by the invention, it is intended to while accurate continuous and high uniformity physiology is provided
Parametric measurement result.Therefore, hardware preferred compensation of the present invention, i.e., the physiological parameter numerical value of two dimension is stored in data memory module
Table, the numerical tabular be corresponding to specified temp sensor signal and other specific described physiological parameter sensing element signals other
Physiological parameter numerical value.Such as partial pressure of oxygen numerical tabular, i.e., temperature sensor signal and partial pressure of oxygen sensor signal it is corresponding under oxygen
Press numerical value.The numerical tabular can write the data memory module in the timing that dispatches from the factory, therefore each probe all corresponds to specifically
Numerical tabular.Due to dispatching from the factory, correction is almost consistent with environment during actual measure for sensor, therefore this hardware is realized
Demarcation temperature-compensating error almost can be ignored, while compensate for probe assembling caused by inconsistency.And it is compensated
Calculating process be then evaluation method of tabling look-up, because temperature fluctuation range is smaller, at 25 DEG C to 50 DEG C, required precision is no more than 0.01
DEG C, other same physiological parameter fluctuation ranges also allow for its applicable inside of human body environment and fluctuation range is smaller, therefore described
The overall amount of data of numerical tabular is smaller, and the table lookup operations time can be ignored completely.So as to realize accurate, real-time, continuous measurement.Phase
By way of carrying out calculating compensation software, suffered from terms of accuracy, reliability, real-time and uniformity significantly excellent
Gesture.
It is embodiment below：
A kind of insertion type medical probe of multi-parameter, top profile is as shown in figure 1, Fig. 1 A-A directions sectional view such as figure
Shown in 2, including：Probing shell 1, temperature-sensing element 7, two kind of other physiological parameter sensing element, and the He of pressure sensor 6
Partial pressure of oxygen sensor, temperature compensation means.
The probing shell 1, has closing head, and position is monitored for intervening；Its middle part has blind hole 3, for assembling
Temperature-sensing element 7；Its side has symmetrically arranged two necks, for assembling other physiological parameter sensing elements；Using
Titanium is integrally formed, and the anterior spherical end surface of probing shell 1, the pressure detecting window at middle part are processed by way of milling
That is the first neck 2, temperature detection blind hole 3, partial pressure of oxygen detection window is the second neck 4, the tubular structure 5 at rear portion.The probe
The front portion of housing 1 is semicircle sphere, and rear portion is tubular structure 5, for being sensed with the temperature-sensing element 7, other physiological parameters
The accessory of element such as conduit 10, wire 11 etc. are assembled.
The temperature-sensing element 7 is assemblied in the blind hole 3；For thermistor, fixed by glue.
The pressure sensor 6, using the micro electronmechanical piezoresistance sensor of absolute pressure type, it is placed in the work that the neck plays positioning
With its surface isolates with tissue covered with biocompatibility silicon rubber barrier film, realization and keeps pressure sensing function.Institute
State barrier film, shore hardness 30A.The square locating slot 12 of pressure detecting window, carrying fixation pressure sensing element 6, is reduced
Difficulty is assembled, improves uniformity between probe individual.
Conduit 10 is fixed in tubular structure 5 by biocompatible glue, and detection fiber 8 has been walked in conduit 10 and has been led
Line 11.Second neck 4 is partial pressure of oxygen detection window, and the partial pressure of oxygen detection window is covered with oxygen molecule permeability
Biocompatibility silicon rubber.The partial pressure of oxygen sensing element includes detection fiber 8 and fluorescent film 13.Inspection described in Photoelectric Detection module
Light-metering fibre 8 is preferably Y shape optical fibre device, and its branch end is connected with excitation source and Photoelectric Detection module respectively；Its other end is
Head is assemblied in by optical fiber mounting hole 9 in the neck of probing shell 1, and the head end is preferably angle end face.The end
Covered with fluorescent film 13, the fluorescent film 13 has oxygen molecule permeability and the fluorescence that can be quenched embedded with its fluorescence by oxygen molecule in face
Dyestuff.The fluorochrome be ruthenium or platinum organic complex as fluorescent dye, such as ruthenium (II)-diimine complex compound.Fluorescent film
13 base material is polystyrene or polyvinyl chloride.The biocompatibility silicon of the permeable oxygen molecule of the detection window filling
Rubber is covered in the surface of fluorescent film 13, ensures good biocompatibility of popping one's head in.Swashed using pulse blue light as exciting light
The fluorescent dye on film 13 that fluoresces sends fluorescence, and fluorescence is transmitted to the Photoelectric Detection module of rear end along detection fiber, passed through
The partial pressure of oxygen information of tissue is obtained to fluorescence decay Analysis of response.
The detection fiber 8 uses big core diameter multimode fibre, and it has larger detection end face, to ensure higher detection
Sensitivity.
The temperature compensation means is connected with temperature-sensing element 7, other physiological parameter sensing element signals；It is used to connect
The real time temperature that shrinkage temperature sensing element 7 determines, and the measured value of other physiological parameter sensing elements is entered according to real time temperature
Row compensation obtains the real-time measurements of other physiological parameters.Before the use, by probe placement in known partial pressure of oxygen and temperature
Calibration environment in, the fluorescence decay obtained by being characterized by linear or polynomial curve fitting responds to be sensed to complete partial pressure of oxygen
Calibrate and obtain temperature compensation parameter.By probe placement in the calibration environment of known pressure and temperature, pass through similar curve
It is fitted to complete the cell calibration of pressure sensor 6 and obtain temperature compensation parameter.
As it will be easily appreciated by one skilled in the art that the foregoing is merely illustrative of the preferred embodiments of the present invention, not to
The limitation present invention, all any modification, equivalent and improvement made within the spirit and principles of the invention etc., all should be included
Within protection scope of the present invention.
Claims (10)
1. the insertion type medical probe of a kind of multi-parameter, it is characterised in that including probing shell, temperature-sensing element, Yi Jizhi
Few other physiological parameter sensing elements of one kind；
The probing shell, has closing head, and position is monitored for intervening；Its middle part has blind hole, is passed for fitting temperature
Sensing unit；Its side has at least one neck, for assembling other physiological parameter sensing elements；
The temperature-sensing element is assemblied in the blind hole；
Other described physiological parameter sensing elements are assemblied in the neck.
2. the insertion type medical probe of multi-parameter as claimed in claim 1, it is characterised in that including temperature compensation means；
The temperature compensation means is connected with temperature-sensing element, other physiological parameter sensing element signals；It is used to receive temperature
The real time temperature of sensing element measure is spent, and the measured value of other physiological parameter sensing elements is compensated according to real time temperature
Obtain the real-time measurements of other physiological parameters.
3. the insertion type medical probe of multi-parameter as claimed in claim 1 or 2, it is characterised in that other described physiological parameters
Sensing element is pressure sensor, and it is assemblied in the neck of probing shell side, and surface is covered with shore hardness 10-
80A barrier film.
4. the insertion type medical probe of multi-parameter as claimed in claim 1 or 2, it is characterised in that other described physiological parameters
Sensing element is that partial pressure of oxygen sensing element includes detection fiber, the detection fiber head be assemblied in for probing shell side
In neck, the neck is covered with the high polymer material with oxygen molecule permeability, preferably silicon rubber.
5. the insertion type medical probe of multi-parameter as claimed in claim 4, it is characterised in that the partial pressure of oxygen sensor includes
Detection fiber and the fluorescent film for covering the detection fiber end face, the fluorescent film have oxygen molecule permeability and are embedded with its fluorescence
The fluorescent dye that can be quenched by oxygen molecule.
6. the insertion type medical probe of multi-parameter as claimed in claim 5, it is characterised in that the detection fiber end face is oblique
Mouth end face.
7. application probe as claimed in claim 4, it is characterised in that the partial pressure of oxygen sensing element includes laser and module occurs
With Photoelectric Detection module；The detection fiber is y-type optical fiber, and with laser module and Photoelectric Detection occur for the both ends of its branch respectively
Module is connected.
8. the insertion type medical probe of multi-parameter as claimed in claim 1, it is characterised in that described it includes various other lifes
Manage parameter sensing element；Its side of the probing shell has the equally distributed neck of respective numbers.
9. the insertion type medical probe of multi-parameter as claimed in claim 8, it is characterised in that including two kinds of other physiological parameters
Sensing element, it is pressure sensor and partial pressure of oxygen sensing element.
10. the insertion type medical probe of multi-parameter as claimed in claim 1, it is characterised in that the probing shell is biology
Compatibility rigid material, preferably titanium alloy, titanium or stainless steel.
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| CN201710783917.7A CN107625516A (en) | 2017-09-04 | 2017-09-04 | A kind of insertion type medical probe of multi-parameter |
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| CN201710783917.7A CN107625516A (en) | 2017-09-04 | 2017-09-04 | A kind of insertion type medical probe of multi-parameter |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109549629A (en) * | 2018-11-29 | 2019-04-02 | 西安交通大学第二附属医院 | A kind of gastroenteritic power detection device |
| CN110074772A (en) * | 2019-05-15 | 2019-08-02 | 长飞光纤光缆股份有限公司 | A kind of pre-calibration intracranial pressure probe |
| CN110196117A (en) * | 2019-05-15 | 2019-09-03 | 长飞光纤光缆股份有限公司 | A kind of two-parameter pre-calibration insertion type probe |
| WO2020154953A1 (en) * | 2019-01-30 | 2020-08-06 | 深圳市科曼医疗设备有限公司 | Apparatus and method for detecting and calibrating intracranial pressure and intracranial temperature |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104905781A (en) * | 2015-02-13 | 2015-09-16 | 林昌军 | Encephalic physiological parameter collecting device and application |
| CN105686811A (en) * | 2016-02-24 | 2016-06-22 | 南京航空航天大学 | Minimally-invasive encephalic multi-parameter detection probe |
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- 2017-09-04 CN CN201710783917.7A patent/CN107625516A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104905781A (en) * | 2015-02-13 | 2015-09-16 | 林昌军 | Encephalic physiological parameter collecting device and application |
| CN105686811A (en) * | 2016-02-24 | 2016-06-22 | 南京航空航天大学 | Minimally-invasive encephalic multi-parameter detection probe |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109549629A (en) * | 2018-11-29 | 2019-04-02 | 西安交通大学第二附属医院 | A kind of gastroenteritic power detection device |
| WO2020154953A1 (en) * | 2019-01-30 | 2020-08-06 | 深圳市科曼医疗设备有限公司 | Apparatus and method for detecting and calibrating intracranial pressure and intracranial temperature |
| CN110074772A (en) * | 2019-05-15 | 2019-08-02 | 长飞光纤光缆股份有限公司 | A kind of pre-calibration intracranial pressure probe |
| CN110196117A (en) * | 2019-05-15 | 2019-09-03 | 长飞光纤光缆股份有限公司 | A kind of two-parameter pre-calibration insertion type probe |
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Application publication date: 20180126 |