CN107621832B - Syringe flow stabilizing device - Google Patents
Syringe flow stabilizing device Download PDFInfo
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- CN107621832B CN107621832B CN201710816183.8A CN201710816183A CN107621832B CN 107621832 B CN107621832 B CN 107621832B CN 201710816183 A CN201710816183 A CN 201710816183A CN 107621832 B CN107621832 B CN 107621832B
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- 230000000087 stabilizing effect Effects 0.000 title claims abstract description 21
- 239000012528 membrane Substances 0.000 claims abstract description 46
- 239000007788 liquid Substances 0.000 claims abstract description 34
- 238000007789 sealing Methods 0.000 claims description 15
- 230000006641 stabilisation Effects 0.000 claims description 7
- 238000011105 stabilization Methods 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 2
- 230000008676 import Effects 0.000 claims 3
- 239000003381 stabilizer Substances 0.000 description 8
- 238000009826 distribution Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000001746 injection moulding Methods 0.000 description 2
- 238000003698 laser cutting Methods 0.000 description 2
- 238000003754 machining Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 238000010999 medical injection Methods 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- -1 polydimethylsiloxane Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000004528 spin coating Methods 0.000 description 1
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Abstract
The invention discloses a flow stabilizing device of an injector, which is characterized in that in order to output stable flow, an elastic membrane which can be deformed under the action of sample liquid pressure and a chamber matched with the elastic membrane are arranged in a sample flow path in the device; when the injector is pushed, the elastic membrane deforms towards the inside of the chamber under the action of the sample liquid pressure, the inner space of the chamber is extruded, the through hole arranged on the elastic membrane is gradually enlarged, and meanwhile, the space of the chamber is gradually reduced, so that the pressure applied to the elastic membrane and the flow resistance in the flow path always keep a direct proportion relation, and the whole flow path can keep stable flow. The injector flow stabilizing device can output accurate and stable sample flow when the injector is driven by hand pushing, and the whole device is small in structure and suitable for portable accurate allocation of samples.
Description
Technical Field
The present invention relates to a flow stabilizer, and more particularly, to a micro flow stabilizer for an injector.
Background
The medical injector is the most common sample injection and distribution tool at present, and is widely used in the fields of medical quantitative administration, instrument sample introduction, experimental sample transportation and distribution and the like. The current driving mode of the injector mainly comprises: mechanical drive and hand-push drive. The mechanical drive is that the precise flow distribution of the sample is realized by pushing the piston rod of the injector by the aid of electric control equipment such as a precise medical injection pump. The method has higher precision, but has the defects of strong equipment dependence, high cost and the like, and is not suitable for portable and quick application occasions. Hand-push drives are the most common, simplest sample-driving format for syringes, but their stability in providing drive flow is severely affected by the operator's level and fails to provide accurate flow output. Therefore, how to output accurate and stable sample flow by adopting a simple and convenient hand-push driving mode has very important practical application value in the field of sample injection and sample introduction.
Disclosure of Invention
The purpose of the invention is as follows: in order to overcome the defects of the prior art, the invention provides the injector flow stabilizing device, which realizes that the injector outputs accurate and stable sample flow under the driving of hand pushing.
The technical scheme is as follows: the invention relates to a flow stabilizing device of an injector, which comprises a body, wherein a sample inlet and a sample outlet are respectively arranged at two ends of the body, and a liquid inlet channel communicated with the sample inlet, a liquid outlet channel communicated with the sample outlet and a flow stabilizing structure connected between the liquid inlet channel and the liquid outlet channel are arranged in the body; the flow stabilizing structure comprises an elastic membrane, a cavity and a radial channel; the elastic membrane deforms towards the inside of the cavity under the pressure action of the sample liquid, and a through hole for communicating the liquid inlet channel with the cavity is formed in the elastic membrane; the cavity is in a groove shape; one end of the radial channel is communicated with the side wall of the groove of the cavity, and the other end of the radial channel is communicated with the liquid outlet channel.
The working principle of the invention is as follows: the head of the syringe is directly inserted into the sample inlet, and when the syringe is pushed, the sample liquid flows in from the sample inlet, flows through the liquid inlet channel, the through hole of the elastic membrane, the chamber, the radial channel and the liquid outlet channel, and is finally led out from the sample outlet. Wherein, the elastic membrane is a deformable elastic membrane, and under the pressure action of the sample liquid, the pressure difference between the upper part and the lower part of the elastic membrane can force the elastic membrane to deform towards the round groove-shaped chamber. When the input pressure changes in a floating manner, for example, from P to P + Δ P, the elastic membrane is further deformed under the action of the increased pressure, so as to approach the bottom of the chamber and squeeze the space of the chamber, and at the same time, the flow of the sample liquid must be diverted to flow out through the radial channel connected with the side wall, so that the flow resistance in the flow path is changed from R to R + Δ R, and the adjustment of the flow resistance compensates for the change of the inlet pressure, so as to obtain a constant output flow Q, which is specifically represented by the following formula:
wherein, P is the pressure difference of two sides of the flow channel, R is the flow resistance, delta P is the pressure increased by the flow channel, and delta R is the flow resistance increased by the deformation of the elastic membrane under the action of delta P. According to the formula, a proper flow path structure is designed, when the pressure and the flow resistance are changed simultaneously, the size of the right side of the equation is not changed, namely the output flow is not changed, and the constant-flow output effect is achieved.
Has the advantages that: according to the injector flow stabilizing device, the elastic membrane and the chamber which deform under the action of the sample liquid pressure are arranged in the flow channel in the device, and the mutual matching of the elastic membrane and the chamber is utilized to control the stability of the flow in the flow channel, so that the accurate and stable sample flow can be output when the injector is driven by hand pushing. The whole device has small and exquisite structure and simple processing and assembly, can be directly loaded on the head of the injector and is suitable for portable and accurate distribution of samples.
Drawings
FIG. 1 is a schematic view of the internal structure of an injector flow stabilizer;
FIG. 2 is a schematic view of the operational principle of the syringe flow stabilizer;
FIG. 3 is an exploded view of the syringe flow stabilizer assembly;
FIG. 4 is a schematic view of the inlet piece construction;
FIG. 5 is a schematic view of the outlet member;
FIG. 6 is a flow output test result of different sizes of injector flow stabilizers at different pressures;
fig. 7 is a flow output stability test result of the injector flow stabilization device.
Detailed Description
The following describes in further detail how the present invention can be implemented with reference to the accompanying drawings.
In order to realize that the conventional injector can output accurate and stable sample flow under the driving of hand pushing, the invention provides an injector flow stabilizing device. As shown in figure 1, a flow path capable of stabilizing the flow rate of sample liquid is arranged in the device, and the flow path comprises a liquid inlet channel 1, a through hole 21 arranged on an elastic membrane 2, a chamber 3, a radial channel 4 and a liquid outlet channel 5. As shown in fig. 2, when the syringe is pushed by hand to drive the sample liquid, the elastic membrane 2 is deformed into the chamber 3 by the sample liquid pressure, gradually approaches the bottom of the chamber 3, and squeezes the space of the chamber 3. In the process of gradually deforming the elastic membrane 2, the through hole 21 gradually becomes larger and wider, the chamber 3 space gradually decreases, and the flow path becomes narrower, so that the pressure exerted on the elastic membrane 2 and the flow resistance in the flow path always keep a direct proportion relation, and therefore, the flow of the whole flow path can be basically kept stable through the cooperation of the elastic membrane 2 and the chamber 3.
Referring to fig. 3, the body structure of the injector flow stabilizing device comprises an inlet piece 6, a sealing gasket 10, an elastic membrane 2 and an outlet piece 7. The inlet piece 6 and the outlet piece 7 are tightly connected to form a seal, and the gasket 10 and the elastic membrane 2 are compressed between the inlet piece 6 and the outlet piece 7. The two ends of the body are respectively provided with a sample inlet 8 and a sample outlet 9, the sample inlet 8 and the sample outlet 9 are both standard luer connectors, the sample inlet 8 can be directly inserted into the injector and realize the sealing connection with the injector, and the sample outlet 9 can be directly inserted into the injector needle or other luer connector pipeline connectors. The sealing gasket 10 is provided with a layer-penetrating circular hole 11, and the layer-penetrating circular hole 11 and a pore passage 12 which is arranged inside the inlet piece 6 and communicated with the sample inlet 8 jointly form a liquid inlet channel 1.
Referring to fig. 4, the inlet piece 6, which has a regular cylindrical body, can be made of plastic, stainless steel, etc. by machining, injection molding, and three-dimensional additive manufacturing. A sample inlet 8 is formed at one end of the inlet member 6 on the central axis of the cylinder. The inlet channel 1 is connected to the sample inlet 8, and the inlet channel 1 is also located on the central axis of the cylinder. The other end of the inlet piece 6 is provided with a large concentric circular groove and a small concentric circular groove on the surface connected with the outlet piece, the large concentric circular groove is a first circular groove 61, the second circular groove 62 is a second circular groove 62, and clamping grooves 63 are arranged at the symmetrical positions of the two sides of the first circular groove 61.
As shown in fig. 5, the outlet member 7, the main body of which is also a regular cylinder, can be made of plastic, stainless steel, etc. by machining, injection molding and three-dimensional additive manufacturing. A sample outlet 9 is formed at one end of the outlet member 7, and the position of the sample outlet 9 is offset from the central axis of the cylinder. The surface of the end of the outlet member 7 connected with the inlet member 6 is also provided with a large concentric circular groove and a small concentric circular groove, the centers of which are located on the central axis of the cylinder, and the large concentric circular groove and the small concentric circular groove are respectively a third circular groove 73 and a chamber 3, and the diameter of the third circular groove 73 is consistent with that of the second circular groove 62. A cutting groove for communicating the cavity 3 and the liquid outlet channel 5 is formed along the radial direction of the cavity 3, namely a radial channel 4, one end of the radial channel 4 is connected to the side wall of the cavity 3, and the other end of the radial channel 4 is connected with an inlet round hole of the liquid outlet channel 5; the cavity 3 can also be arranged into a groove with other shapes, and the radial channel 4 is led out from the side wall of the groove of the cavity 3 and communicated with the liquid outlet channel 5; the circular recess is preferred because the elastic membrane 2 cooperates with the circular recess-like chamber 3 for a better stable control of the flow. The outlet channel 5 extends inside the outlet member 7 and communicates with the sample outlet 9. The diameter of the main body cylinder of the outlet member 7 is the same as the diameter of the first circular groove 61 of the inlet member 6, and the two sides of the outlet member 7 are provided with the buckles 72 used in cooperation with the clamping grooves 63, so that the outlet member 7 can be tightly connected to the inlet member 6 through the rotation fit of inserting the buckles 72 into the clamping grooves 63. And the contact surface of the two is positioned in the first circular groove 61, and the sealing performance of the connection of the two is enhanced.
The elastic membrane 2 is a disk-shaped thin membrane processed by laser cutting, is assembled in the third circular groove 73, and integrally covers the cavity 3, the radial channel 4 and the inlet circular hole of the liquid outlet channel 5. The diameter of the elastic membrane 2 may be the same as the diameter of the gasket 10 or slightly smaller than the diameter of the gasket 10; the through hole 21 of the elastic membrane 2 is a small-size round hole, the diameter of the through hole is far smaller than the diameter of the cross section of the chamber 3, and the through hole 21, the layer penetrating round hole 11 and the chamber 3 are all positioned on the same axis; the elastic membrane 2 can be made of materials with excellent elasticity such as polydimethylsiloxane and the like by means of a high-speed spin coating method, and the central through hole 21 is also formed by laser cutting; the elastic membrane 2 is sealingly bonded to the outlet member 7 by means of pressure, adhesive or chemical bonding.
The sealing gasket 10 is a circular sealing gasket and is made of materials with certain elasticity, such as silica gel and rubber, the diameter of the sealing gasket 10 is the same as that of the second circular groove 62 and that of the third circular groove 73, and the thickness of the sealing gasket 10 is slightly larger than the sum of the depths of the second circular groove 62 and that of the third circular groove 73, so that when the sealing gasket 10 and the elastic membrane 2 are installed between the second circular groove 62 and the third circular groove 73, the elastic membrane 2 and the outlet member 7 can be tightly pressed through the elasticity of the sealing gasket 10, and the bonding sealing effect of the elastic membrane 2 and the outlet member 7 is further enhanced.
When the injector flow stabilizing device is used, parameters influencing the output flow of the injector flow stabilizing device include the diameter of the through hole 21 of the elastic membrane 2 and the height of the chamber 3, namely the depth of the chamber 3. For convenience of description, the syringe flow stabilizing devices of different dimensions are defined by the reference HaDb, where H denotes the sign of the height of the chamber 3, a denotes the value of the height of the chamber 3 in microns, D denotes the diameter of the through hole 21 of the elastic membrane 2, b denotes the value of the diameter of the through hole 21 in 102Micron, e.g., D2, indicates a circular hole diameter of 200 microns. As shown in FIG. 5, the flow stabilizers of six different sizes of injectors are at different pressuresThe flow output value under the strong condition shows that all the injector flow stabilizing devices can output stable flow when the pressure reaches the threshold pressure.
As shown in fig. 6, the stability test result is output for the flow rate of the injector flow rate stabilizing device; wherein, the upper wavy line is a pressure numerical curve, and the lower wavy line is a flow numerical curve. The effect of fluctuating pressure on output flow stability was tested using an example injector flow stabilizer model H100D2, i.e. a chamber 3 with a height of 100 microns and a through hole diameter of 200 microns. The input pressure is set to be in sinusoidal variation, the amplitude is 80-100 kPa, and the period is 4 s. The test result shows that the maximum value of the output flow of the injector flow stabilizing device is 1.26ml/min, the minimum value is 1.125ml/min, the average value is 1.198ml/min, and the flow deviation is only 5.84%.
Claims (7)
1. An injector flow stabilizing device, comprising: the device comprises a body, wherein a sample inlet (8) and a sample outlet (9) are respectively arranged at two ends of the body, a liquid inlet channel (1) communicated with the sample inlet (8), a liquid outlet channel (5) communicated with the sample outlet (9) and a flow stabilizing structure connected between the liquid inlet channel (1) and the liquid outlet channel (5) are arranged in the body; the flow stabilizing structure comprises an elastic membrane (2), a chamber (3) and a radial channel (4); the elastic membrane (2) is circular and integrally covers the cavity (3), the radial channel (4) and the inlet round hole of the liquid outlet channel (5); the elastic membrane (2) deforms towards the inside of the cavity (3) under the pressure action of the sample liquid, and a through hole (21) for communicating the liquid inlet channel (1) with the cavity (3) is formed in the center of the elastic membrane (2); the cavity (3) is in a circular groove shape, and the central axes of the liquid inlet channel (1), the through hole (21) and the cavity (3) are overlapped; one end of the radial channel (4) is communicated with the groove side wall of the chamber (3), and the other end of the radial channel extends outwards along the radial direction of the chamber (3) and is communicated with the liquid outlet channel (5).
2. The syringe flow stabilization device of claim 1, wherein: the body comprises an inlet piece (6) and an outlet piece (7), the sample inlet (8) is arranged at one end of the inlet piece (6), and the sample outlet (9) is arranged at one end of the outlet piece (7); the other end of the inlet piece (6) is tightly connected with the other end of the outlet piece (7).
3. The injector flow stabilization device of claim 2, wherein: the elastic membrane (2) is arranged between the inlet piece (6) and the outlet piece (7), and the elastic membrane (2) and the outlet piece (7) are mutually bonded in a pressing, bonding or chemical bonding mode.
4. The injector flow stabilization device of claim 3, wherein: a sealing gasket (10) is arranged between the elastic membrane (2) and the inlet piece (6), the elastic membrane (2) and the sealing gasket (10) are both circular, and the diameter of the elastic membrane (2) is less than or equal to that of the sealing gasket (10); the sealing gasket (10) is pressed against the elastic membrane (2).
5. The injector flow stabilization device of claim 2, wherein: the one end that export piece (7) and import piece (6) are connected is cylindrical, be provided with first circular slot (61) on import piece (6), export piece (7) are connected in first circular slot (61).
6. The injector flow stabilization device of claim 4, wherein: be provided with second circular slot (62) on import piece (6), be provided with third circular slot (73) on export piece (7), the diameter of second circular slot (62), third circular slot (73) and sealed pad (10) is unanimous, and the thickness of sealed pad (10) is greater than the degree of depth sum of second circular slot (62) and third circular slot (73), and sealed pad (10) sticiss between second circular slot (62) and third circular slot (73).
7. The syringe flow stabilization device of claim 1, wherein: the sample inlet (8) and the sample outlet (9) are both standard luer connectors.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710816183.8A CN107621832B (en) | 2017-09-11 | 2017-09-11 | Syringe flow stabilizing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710816183.8A CN107621832B (en) | 2017-09-11 | 2017-09-11 | Syringe flow stabilizing device |
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| Publication Number | Publication Date |
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| CN107621832A CN107621832A (en) | 2018-01-23 |
| CN107621832B true CN107621832B (en) | 2020-07-31 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710816183.8A Active CN107621832B (en) | 2017-09-11 | 2017-09-11 | Syringe flow stabilizing device |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108333382B (en) * | 2018-04-17 | 2021-03-19 | 东南大学 | Mechanically-driven accurate sample introduction device |
| CN110285246A (en) * | 2019-07-25 | 2019-09-27 | 汉盛（上海）海洋装备技术股份有限公司 | A kind of constant device of reed-type adaptive flow |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1077909A (en) * | 1992-01-24 | 1993-11-03 | 普拉斯特罗-格瓦特公司 | Regulated drip irrigation emitter |
| JP2003049959A (en) * | 2001-08-03 | 2003-02-21 | Asahi Organic Chem Ind Co Ltd | Pinch valve |
| EP1321156A1 (en) * | 2001-12-19 | 2003-06-25 | WEX, Roland | Valve ensuring a substantially constant fluid flow |
| CN2569188Y (en) * | 2002-07-05 | 2003-08-27 | 程序 | Current stabilizer |
| CN204017027U (en) * | 2014-07-21 | 2014-12-17 | 李为松 | A kind of intravenous injector |
| CN107126600A (en) * | 2017-05-23 | 2017-09-05 | 北京大学深圳医院 | Isolation protector and the injection device with the Isolation protector |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8034029B2 (en) * | 2005-05-25 | 2011-10-11 | Palyon Medical (Bvi) Limited | Multi-reservoir implantable pump with patient controlled actuation |
-
2017
- 2017-09-11 CN CN201710816183.8A patent/CN107621832B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1077909A (en) * | 1992-01-24 | 1993-11-03 | 普拉斯特罗-格瓦特公司 | Regulated drip irrigation emitter |
| JP2003049959A (en) * | 2001-08-03 | 2003-02-21 | Asahi Organic Chem Ind Co Ltd | Pinch valve |
| EP1321156A1 (en) * | 2001-12-19 | 2003-06-25 | WEX, Roland | Valve ensuring a substantially constant fluid flow |
| CN2569188Y (en) * | 2002-07-05 | 2003-08-27 | 程序 | Current stabilizer |
| CN204017027U (en) * | 2014-07-21 | 2014-12-17 | 李为松 | A kind of intravenous injector |
| CN107126600A (en) * | 2017-05-23 | 2017-09-05 | 北京大学深圳医院 | Isolation protector and the injection device with the Isolation protector |
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| CN107621832A (en) | 2018-01-23 |
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