CN107609727A - A kind of Cell Culture Lab total management system and method - Google Patents

A kind of Cell Culture Lab total management system and method Download PDF

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CN107609727A
CN107609727A CN201710613523.7A CN201710613523A CN107609727A CN 107609727 A CN107609727 A CN 107609727A CN 201710613523 A CN201710613523 A CN 201710613523A CN 107609727 A CN107609727 A CN 107609727A
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cell
culture
module
cell culture
management
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CN107609727B (en
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顾雨春
刘晓庆
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Beijing Promise Medical Science And Technology Co Ltd
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Abstract

The present invention relates to a kind of Cell Culture Lab total management system and method.This method passes through rational Functional Design, system module design, effectively realize to cell culture experiments whole process integrated management, realize the electronization held before, during and after whole flow process, improve operating efficiency, and using the system architecture towards Interface design, the access of operatively compatible various operation terminals, adapts to the use demand of a variety of mobile contexts of Modern Laboratory, realizes multiple terminals coordinated management.For cell cultivation process management, carry out real-time monitoring record, culture data upload in real time, ensure that whole incubation meets production requirement, for cell culture Management of quality control, used by equipment, the real-time typing of the data such as consumptive material uses, detection records and record, ensure trackability, it is ensured that production cell quality.

Description

A kind of Cell Culture Lab total management system and method
Technical field
The present invention relates to Design of Laboratory Management System technical field, and in particular to a kind of Cell Culture Lab integrated management system System and method.
Background technology
The cell culture experimental technique means indispensable as modern medicine or even whole life science, are all kinds of The important component of experimental technique platform.Cell culture is more embodied in culture skill in addition to needing consummate operating technology The process of art is complicated, and sterile requirement is strict.The factor of influence cell culture success or failure is a lot, and any one link goes wrong, It is unqualified Cell-Culture products to be directly resulted in.The management of Cell Culture Lab at this stage is mainly by hand-kept and reality Room on-the-spot guidance supervision is tested, who enters whose management of laboratory, as a result causes to suffer setbacks repeatedly in cell cultivation process.For carrying out It is independent that the mechanism of cell culture business, its business department, production division, logistics department etc. commence business in the process of running , cause to carry out in cell culture business procedure, because linking up delay or not smooth, cell culture failure easily occur, cause the time And cost allowance, it is often more important that most probably for being badly in need of impacting using the unit or personnel of cell.Therefore, for whole Individual cell culture business and Cell Culture Lab, it is badly in need of effective total management system, owns in integrator cell incubation Link, carry out unified management control, improve the control dynamics in incubation, ensure cell culture operation flow and cell training Foster laboratory being capable of normal operation., can be right during exquisite detail experiment by Cell Culture Lab total management system In the operational circumstances of material, the service condition of equipment, in real time monitoring producers.
Existing Routine Test Lab workflow management software, relate generally to traditional laboratory room managing flow.Functionally without Method meets the control of each link of cell culture operation flow, and can not more meet cell cultivation process and quality control process management will Ask.
In addition, prior art at cross-platform aspect there is also defect, with the popularization and variation of access terminals, across setting Standby, cross-platform display becomes more and more important, and prior art only realizes the use of PC terminals, can not meet the collaboration of multiple terminals Management.
The content of the invention
In view of the shortcomings of the prior art, the present invention is intended to provide a kind of Cell Culture Lab total management system and side Method, by rational Functional Design, system module design, effectively realize to cell culture experiments whole process integrated management, it is real The real-time electronic monitoring management held before, during and after existing whole flow process, improves operating efficiency.And it is using towards Interface design System framework, the accesses of operatively compatible various operation terminals, adapts to the use demand of a variety of mobile contexts of Modern Laboratory, realizes Multiple terminals coordinated management.For cell cultivation process management, real-time monitoring record is carried out, culture data are uploaded, ensured whole in real time Individual incubation meets production requirement, for cell culture Management of quality control, is used by equipment, consumptive material uses, detection records The real-time typing of data and record, ensure trackability, it is ensured that production cell quality.
To achieve these goals, the present invention adopts the following technical scheme that:
A kind of Cell Culture Lab total management system, including cell culture experiments comprehensive management module, cell culture Process management module, cell culture Management of quality control module;
The cell culture experiments comprehensive management module includes client information management module, cell sample freezes management mould Block, purchasing management module, inventory management module, culture project management module, personal management module, data query and statistics mould Block;
The cell cultivation process management module includes cell culture task module, cell culture logging modle, cultivated Journey picture recording module;
The cell culture Management of quality control module, which includes culture record supervisor module, culture video recording supervisor module, instrument, to be made Tracing module is flowed to record supervisor module, microorganism detection logging modle, cell detection logging modle, reagent consumptive material.
On the basis of above-mentioned technical proposal, the client information management module is used for managing customer information;The cell Sample freezes management module and freezes sample information record management for client;The purchasing management module is used to purchase reagent consumption Material;The inventory management module is used for the Inventory Performance of control inspection reagent consumptive material;The culture project management module is used to manage Manage cell culture project;The personal management module is used to manage cell culture personnel;The data query and statistical module are used In tracing the buying situation of reagent consumptive material, get situation and service condition.
On the basis of above-mentioned technical proposal, the cell culture task module is used to record cell culture task;It is described Cell culture logging modle is used for growth conditions, cell quantity, cell photo, the growth course video record for recording cell, training The data such as actual reagent consumption, instrument usage record during supporting;The incubation picture recording module is used to record cell training Operational circumstances during supporting.
On the basis of above-mentioned technical proposal, culture record supervisor's module is used for the culture record for verifying culture person; Culture video recording supervisor's module is used for the video recording of cell growth process video and carries out long-range Quality Control;The instrument usage record is superintended and directed Module is examined to be used to carry out long-range Quality Control to instrument usage record data;The microorganism detection logging modle is used for cell culture In microorganism detection result data recorded;The cell detection logging modle is used for the growth conditions to cell, cell The data such as quantity, cell photo carry out long-range Quality Control;The reagent consumptive material flows to tracing module and is used for the reality in incubation Border reagent consumptive material flows to data and carries out long-range Quality Control.
A kind of Cell Culture Lab flow Management of quality control method, using above-mentioned Cell Culture Lab integrated management system System, comprises the following steps:
(1) when producing culture order, related management personnel pass through customer information typing client information management module Culture project management module establishes culture project;
(2) after receiving the sample of client in laboratory, sample is frozen, and recorded cell sample and freeze management mould Block;
(3) external coordination personnel in laboratory audit order and whether sample information matches, checks reagent by inventory management module Whether consumptive material is complete, if matching and complete, cellulation culture task, and would upload to cell culture task module;If Reagent consumptive material deficiency by purchasing management module, it is necessary to purchase novel agent consumptive material;
(4) cell culture person gets cultivate reagent, proceeds by the culture of cell, together according to cell culture mission requirements When typing culture project management module and personal management module;
(5) cell culture person remembers cell cultivation process, it is necessary to open multimedia video recording equipment in cell cultivation process Record incubation picture recording module;
(6) cell culture person is needed after daily cell culture task is completed, and passes through mobile terminal or PC terminal handles Growth conditions, cell quantity, cell photo, the growth course video record of cell, the actual reagent consumption in incubation, instrument The data such as device usage record, it imperfectly recorded in culture record, upload to cell culture logging modle;
(7) Quality Control personnel can be verified every daily by mobile terminal or PC terminals by cell culture Management of quality control module The culture record of individual culture person, carries out long-range Quality Control, Quality Control scope includes:The growth conditions of cell, cell quantity, cell shine Piece, cell growth process video record, the data such as actual reagent consumption, instrument usage record in incubation;
(8) cell cultivation process key node, it is necessary to carry out necessary detection to cell, testing result needs to upload To cell detection logging modle;
(9) until the culture of completion cell, culture task is closed;
(10) if Quality Control personnel have found that certain batch reagent has problem, can be integrated by the Cell Culture Lab Purchasing management module, inventory management module and the data query and statistical module of management system directly trace adopting for the batch products Purchase situation, situation and service condition, and then the effectively coverage of control problem are got, trace question classification.
On the basis of above-mentioned technical proposal, the sample of client includes blood and histocyte in step (2).
On the basis of above-mentioned technical proposal, the product in step (10) is reagent consumptive material.
The invention has the advantages that:
By the system and method for the present invention, effective linking to each link of cell culture workflow have effectively achieved And management, the use flow direction to cell cultivation process each time, cell culture result and each batch reagent consumptive material exercise supervision Control, meets the requirement of cell cultivation process and quality control process management.Multimedia technology and network are innovatively utilized, to cell Growth course, cell culture operations process carry out multimedia video recording.
Using the architecture design towards interface, and the system architecture of multiple terminals collaboration is realized, adapt to modern multiple terminals ring User's use habit under border, and then Quality Control scope and ability are expanded, the efficiency and effect of Management of quality control are improved, is realized Remotely, efficient Management of quality control.
Brief description of the drawings
The present invention has drawings described below:
Fig. 1 Cell Culture Lab total management system structural representations.
Fig. 2 Cell Culture Lab flow Management of quality control schematic diagrames.
Embodiment
The present invention is described in further details below in conjunction with accompanying drawing and specific implementation case.
As shown in figure 1, a kind of Cell Culture Lab total management system, including cell culture experiments integrated management mould Block, cell cultivation process management module, cell culture Management of quality control module;
The cell culture experiments comprehensive management module includes client information management module, cell sample freezes management mould Block, purchasing management module, inventory management module, culture project management module, personal management module, data query and statistics mould Block;
The cell cultivation process management module includes cell culture task module, cell culture logging modle, cultivated Journey picture recording module;
The cell culture Management of quality control module, which includes culture record supervisor module, culture video recording supervisor module, instrument, to be made Tracing module is flowed to record supervisor module, microorganism detection logging modle, cell detection logging modle, reagent consumptive material.
On the basis of above-mentioned technical proposal, the client information management module is used for managing customer information;The cell Sample freezes management module and freezes sample information record management for client;The purchasing management module is used to purchase reagent consumption Material;The inventory management module is used for the Inventory Performance of control inspection reagent consumptive material;The culture project management module is used to manage Manage cell culture project;The personal management module is used to manage cell culture personnel;The data query and statistical module are used In tracing the buying situation of reagent consumptive material, get situation and service condition.
On the basis of above-mentioned technical proposal, the cell culture task module is used to record cell culture task;It is described Cell culture logging modle is used for growth conditions, cell quantity, cell photo, the growth course video record for recording cell, training The data such as actual reagent consumption, instrument usage record during supporting;The incubation picture recording module is used to record cell training Operational circumstances during supporting.
On the basis of above-mentioned technical proposal, culture record supervisor's module is used for the culture record for verifying culture person; Culture video recording supervisor's module is used for the video recording of cell growth process video and carries out long-range Quality Control;The instrument usage record is superintended and directed Module is examined to be used to carry out long-range Quality Control to instrument usage record data;The microorganism detection logging modle is used for cell culture In microorganism detection result data recorded;The cell detection logging modle is used for the growth conditions to cell, cell The data such as quantity, cell photo carry out long-range Quality Control;The reagent consumptive material flows to tracing module and is used for the reality in incubation Border reagent consumptive material flows to data and carries out long-range Quality Control.
As shown in Fig. 2 a kind of Cell Culture Lab flow Management of quality control method, comprehensive using above-mentioned Cell Culture Lab Management system is closed, is comprised the following steps:
(1) when producing culture order, related management personnel pass through customer information typing client information management module Culture project management module establishes culture project;
(2) after receiving the sample of client in laboratory, sample is frozen, and recorded cell sample and freeze management mould Block;
(3) external coordination personnel in laboratory audit order and whether sample information matches, checks reagent by inventory management module Whether consumptive material is complete, if matching and complete, cellulation culture task, and would upload to cell culture task module;If Reagent consumptive material deficiency by purchasing management module, it is necessary to purchase novel agent consumptive material;
(4) cell culture person gets cultivate reagent, proceeds by the culture of cell, together according to cell culture mission requirements When typing culture project management module and personal management module;
(5) cell culture person remembers cell cultivation process, it is necessary to open multimedia video recording equipment in cell cultivation process Record incubation picture recording module;
(6) cell culture person is needed after daily cell culture task is completed, and passes through mobile terminal or PC terminal handles Growth conditions, cell quantity, cell photo, the growth course video record of cell, the actual reagent consumption in incubation, instrument The data such as device usage record, it imperfectly recorded in culture record, upload to cell culture logging modle;
(7) Quality Control personnel can be verified every daily by mobile terminal or PC terminals by cell culture Management of quality control module The culture record of individual culture person, carries out long-range Quality Control, Quality Control scope includes:The growth conditions of cell, cell quantity, cell shine Piece, cell growth process video record, the data such as actual reagent consumption, instrument usage record in incubation;
(8) cell cultivation process key node, it is necessary to carry out necessary detection to cell, testing result needs to upload To cell detection logging modle;
(9) until the culture of completion cell, culture task is closed;
(10) if Quality Control personnel have found that certain batch reagent has problem, can be integrated by the Cell Culture Lab Purchasing management module, inventory management module and the data query and statistical module of management system directly trace adopting for the batch products Purchase situation, situation and service condition, and then the effectively coverage of control problem are got, trace question classification.
On the basis of above-mentioned technical proposal, the sample of client includes blood and histocyte in step (2).
On the basis of above-mentioned technical proposal, the product in step (10) is reagent consumptive material.
For those skilled in the art, technical scheme that can be more than and design, make various corresponding Change and deform, and all these change and deformation should be construed as being included within the protection domain of the claims in the present invention.
The content not being described in detail in this specification belongs to prior art known to professional and technical personnel in the field.

Claims (7)

  1. A kind of 1. Cell Culture Lab total management system, it is characterised in that including:Cell culture experiments integrated management mould Block, cell cultivation process management module, cell culture Management of quality control module;
    The cell culture experiments comprehensive management module includes client information management module, cell sample freezes management module, adopted Purchase management module, inventory management module, culture project management module, personal management module, data query and statistical module;
    The cell cultivation process management module includes cell culture task module, cell culture logging modle, incubation record As module;
    The cell culture Management of quality control module includes culture record supervisor module, culture video recording supervisor module, instrument and uses note Record supervisor module, microorganism detection logging modle, cell detection logging modle, reagent consumptive material flow to tracing module.
  2. 2. Cell Culture Lab total management system as claimed in claim 1, it is characterised in that:The client information management Module is used for managing customer information;The cell sample freezes management module and freezes sample information record management for client; The purchasing management module is used to purchase reagent consumptive material;The inventory management module is used for stock's shape of control inspection reagent consumptive material Condition;The culture project management module is used to manage cell culture project;The personal management module is used to manage cell culture Personnel;The data query and statistical module are used to trace the buying situation of reagent consumptive material, get situation and service condition.
  3. 3. Cell Culture Lab total management system as claimed in claim 1, it is characterised in that:The cell culture task Module is used to record cell culture task;The cell culture logging modle be used to recording the growth conditions of cell, cell quantity, Cell photo, growth course video record, actual reagent consumption and instrument usage record in incubation;The incubation Picture recording module is used to record the operational circumstances in cell cultivation process.
  4. 4. Cell Culture Lab total management system as claimed in claim 1, it is characterised in that:The culture record supervisor Module is used for the culture record for verifying culture person;It is described culture video recording supervisor module for cell growth process video record a video into The long-range Quality Control of row;The instrument usage record supervisor module is used to carry out long-range Quality Control to instrument usage record data;It is described micro- Biological detection logging modle is used to record the microorganism detection result data in cell culture;The cell detection record Module is used for the growth conditions to cell, and cell quantity and cell photo carry out long-range Quality Control;The reagent consumptive material flow direction tracking Module is used to flow to the actual reagent consumptive material in incubation the long-range Quality Control of data progress.
  5. 5. a kind of Cell Culture Lab flow Management of quality control method, using above-mentioned Cell Culture Lab total management system, It is characterised in that it includes following steps:
    (1) when producing culture order, customer information typing client information management module is passed through culture by related management personnel Project management module establishes culture project;
    (2) after receiving the sample of client in laboratory, sample is frozen, and recorded cell sample and freeze management module;
    (3) external coordination personnel in laboratory audit order and whether sample information matches, checks reagent consumptive material by inventory management module It is whether complete, if matching and complete, cellulation culture task, and would upload to cell culture task module;If reagent Consumptive material deficiency by purchasing management module, it is necessary to purchase novel agent consumptive material;
    (4) cell culture person gets cultivate reagent, proceeds by the culture of cell, record simultaneously according to cell culture mission requirements Enter to cultivate project management module and personal management module;
    (5) cell culture person recorded cell cultivation process, it is necessary to open multimedia video recording equipment in cell cultivation process Incubation picture recording module;
    (6) cell culture person is needed after daily cell culture task is completed, by mobile terminal or PC terminals cell Growth conditions, cell quantity, cell photo, growth course video record, actual reagent consumption and instrument in incubation Usage record, it imperfectly recorded in culture record, upload to cell culture logging modle;
    (7) Quality Control personnel can verify each training daily by cell culture Management of quality control module by mobile terminal or PC terminals The culture record of member is supported, carries out long-range Quality Control, Quality Control scope includes:The growth conditions of cell, cell quantity, cell photo, carefully Intracellular growth process video is recorded a video, actual reagent consumption and instrument usage record in incubation;
    (8) cell cultivation process key node, it is necessary to carry out necessary detection to cell, testing result needs to upload to thin Born of the same parents detect logging modle;
    (9) until the culture of completion cell, culture task is closed;
    (10) if Quality Control personnel have found that certain batch reagent has problem, the Cell Culture Lab integrated management can be passed through Purchasing management module, inventory management module and the data query and statistical module of system directly trace the buying feelings of the batch products Condition, situation and service condition, and then the effectively coverage of control problem are got, trace question classification.
  6. 6. Cell Culture Lab flow Management of quality control method as claimed in claim 5, it is characterised in that:Institute in step (2) Stating the sample of client includes blood and histocyte.
  7. 7. Cell Culture Lab flow Management of quality control method as claimed in claim 5, it is characterised in that:Institute in step (10) The product stated is reagent consumptive material.
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CN110232546A (en) * 2019-06-11 2019-09-13 北京臻溪谷医学研究中心(有限合伙) A kind of distribution cell Development of intelligent laboratory management system
CN110647779A (en) * 2018-06-26 2020-01-03 深圳市北科生物科技有限公司 Information tracking method and system in cell culture process
CN111077787A (en) * 2019-12-23 2020-04-28 深圳赛动生物自动化有限公司 Stem cell automatic preparation monitoring system and monitoring method thereof
CN111476517A (en) * 2020-03-13 2020-07-31 青岛海尔生物医疗股份有限公司 Cell culture management system
CN113962569A (en) * 2021-10-26 2022-01-21 冰山松洋生物科技(大连)有限公司 Biological laboratory integrated management system based on cloud service
CN117789835A (en) * 2023-12-27 2024-03-29 江苏睿景生物技术有限公司 Intelligent management system for cell culture data in biological laboratory

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CN110647779A (en) * 2018-06-26 2020-01-03 深圳市北科生物科技有限公司 Information tracking method and system in cell culture process
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CN117789835B (en) * 2023-12-27 2024-06-04 江苏睿景生物技术有限公司 Intelligent management system for cell culture data in biological laboratory

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