CN107595905A - The defervescence plaster used and preparation method prepared is combined by paracetamol and bupleurum Chinense volatile oil - Google Patents
The defervescence plaster used and preparation method prepared is combined by paracetamol and bupleurum Chinense volatile oil Download PDFInfo
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- CN107595905A CN107595905A CN201710880126.6A CN201710880126A CN107595905A CN 107595905 A CN107595905 A CN 107595905A CN 201710880126 A CN201710880126 A CN 201710880126A CN 107595905 A CN107595905 A CN 107595905A
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Abstract
The invention discloses it is a kind of by paracetamol and bupleurum Chinense volatile oil combine prepare defervescence plaster used and preparation method, wherein, it is defervescence plaster used including：50~400 milligrams of paracetamol, 0.5~1.0 microlitre of bupleurum Chinense volatile oil and defervescence plaster used matrix；The paracetamol and the bupleurum Chinense volatile oil mix with the defervescence plaster used matrix, and by the mixed defervescence plaster used substrate application between the back lining materials and the lid lining material；Wherein, the bupleurum Chinense volatile oil is that the radix bupleuri after biological enzymolysis utilizes the volatile oil for distilling extraction.By technical scheme, the possibility that oral drugs cause uncomfortable reaction and the infringement to liver kidney to intestines and stomach is reduced, the duration of bringing down a fever is extended, enhances effect of bringing down a fever.
Description
Technical field
The present invention relates to Chinese and Western medicine applied technical field, more particularly to one kind is by paracetamol and bupleurum Chinense volatile oil group
Close the defervescence plaster used and defervescence plaster used preparation method prepared.
Background technology
Heating is one of most common clinical symptoms of paediatrics, is usually caused by virus, bacterium infection or other diseases.Hair
Heat is a kind of aversion response of human body, and the phagocytic function of reticuloendothelial system can be stimulated by heating, forms antibody, and increase is white
Cell viability and liver detoxification effect etc..But high fever can cause organism metabolism obstacle and each system dysfunction.Children god
It is not perfect enough through systematic growth, easily fainted from fear in adstante febre, brain cell may be damaged, so as to cause adverse consequences.
Therefore, to the infant that generates heat, in addition to being treated for the cause of disease, the body temperature of infant should be reduced using the antipyretic of effective and safe,
Avoid the infringement consumed excessively with organ of body.
Paracetamol be WHO recommend more than 2 months children preferred antipyretic, the asthma that is particularly suitable for use in, influenza and
The fever patient of varicella, better tolerance, medication are safer.When more than 40 DEG C of body temperature is appropriate to the occasion from acting on comparatively gentle medicines,
And using low dose, because body temperature is higher, body is more sensitive to alexipyretic, and body temperature can be made to decline suddenly with a large amount of perspire and cause
Collapse or shock.It is rapid complete that absorption is administered orally, but its adverse reaction has fash, drug fever and mucosa injury, can cause liver
Renal damage, excessive use may cause toxic reaction.Tylenol main component in solution is paracetamol, extensive use
Generated heat in children's cold, but its weak point is hold time short (about 3~4 hours) of bringing down a fever, and hepatic lesion can be caused by being excessively used
Deng side effect.
The content of the invention
At least one of regarding to the issue above, the invention provides one kind by paracetamol and bupleurum Chinense volatile oil group
Close the defervescence plaster used and its preparation method prepared, from the preferable Western medicine paracetamol of effect of bringing down a fever and anti-inflammatory, it is antipyretic in
A kind of the defervescence plaster used of external application is prepared in the volatile oil combination of medicine radix bupleuri, reduce oral drugs intestines and stomach are caused uncomfortable reaction and
The possibility of infringement to liver kidney, extends the duration of bringing down a fever, and enhances effect of bringing down a fever.
To achieve the above object, moving back for preparation is combined by paracetamol and bupleurum Chinense volatile oil the invention provides a kind of
Heat posted, including：50~400 milligrams of paracetamol, 0.5~1.0 microlitre of bupleurum Chinense volatile oil and defervescence plaster used matrix；It is described
Paracetamol and the bupleurum Chinense volatile oil mix with the defervescence plaster used matrix, and by the mixed defervescence plaster used matrix
Coated between the back lining materials and the lid lining material；Wherein, the bupleurum Chinense volatile oil is the radix bupleuri profit after biological enzymolysis
With the volatile oil of distillation extraction.
In the technical scheme, from the preferable Western medicine paracetamol of effect of bringing down a fever and anti-inflammatory, antipyretic Chinese medicine bavin
A kind of the defervescence plaster used of external application is prepared in the volatile oil combination of Hu, reduces oral drugs and intestines and stomach are caused with uncomfortable react and to liver
The possibility of the infringement of kidney, extends the duration of bringing down a fever, and enhances effect of bringing down a fever.
Wherein, biological enzymolysis is carried out to bupleurum Chinese using extracellular biology enzyme, the cell membrane of radix bupleuri is destroyed, improved
Extraction to active ingredient in Radix Bupleuri.The radix bupleuri solution containing active ingredient extracted is subjected to distillation extraction again,
Purer bupleurum Chinense volatile oil is obtained, improves the effect of bringing down a fever of radix bupleuri.
Specifically, often paste the defervescence plaster used paracetamol for including 50~400 milligrams and 0.5~1.0 microlitre of radix bupleuri
Volatile oil, Chinese medicine and Western medicine act to human body jointly, improve defervescence plaster used effect of bringing down a fever.
In the above-mentioned technical solutions, it is preferable that above-mentioned that bringing down a fever for preparation is combined by paracetamol and bupleurum Chinense volatile oil
Patch also includes defervescence plaster used matrix, and the defervescence plaster used matrix includes：First permeation enhancers, the second permeation enhancers, desensitizer, antioxygen
Agent, crosslinking agent, cross-linked scaffold material, cross-linking regulator, tackifier and complexing agent, first permeation enhancers and described second promote
Bleeding agent is used for the skin permeability for improving paracetamol, and the crosslinking agent and the cross-linking regulator are described for promoting
The crosslinking of cross-linked scaffold material.
In the technical scheme, using defervescence plaster used matrix, paracetamol and bupleurum Chinense volatile oil are blended in defervescence plaster used
To produce medicine effect to human body in matrix, wherein, the first permeation enhancers and the second permeation enhancers are used to improve acetparaminosalol
The skin permeability of phenol, promotes the active ingredient in medicine to infiltrate through skin, and crosslinking agent and cross-linking regulator are used to promote to be crosslinked
The crosslinking of framework material, desensitizer are used to reduce allergic reaction of the skin to medicine, antioxidant be used to strengthening defervescence plaster used matrix and
The inoxidizability of paracetamol and bupleurum Chinense volatile oil, tackifier and complexing agent are used for defervescence plaster used matrix, acetparaminosalol
The harmony of phenol and bupleurum Chinense volatile oil composition, strengthen the viscosity of defervescence plaster used matrix, so as to ensure defervescence plaster used normal use.
In the above-mentioned technical solutions, it is preferable that first permeation enhancers include menthol and azone, and described second promotees to ooze
Saturating agent is propane diols, and the desensitizer is promethazine hydrochloride, and the antioxidant is sodium sulfite, and the crosslinking agent is Dihydroxyaluminium Aminoacetate,
The cross-linked scaffold material is incomplete neutralization type polyacrylic acid, and the cross-linking regulator is tartaric acid, and the tackifier include
Polyvinylpyrrolidone and sodium cellulose glycolate, the complexing agent are disodium ethylene diamine tetraacetate.
In the technical scheme, the first permeation enhancers select menthol and water-solubleazone, and the second permeation enhancers select third
Glycol, desensitizer select promethazine hydrochloride, and antioxidant selects sodium sulfite, and crosslinking agent selects Dihydroxyaluminium Aminoacetate, the choosing of cross-linked scaffold material
Cannot be used up full neutralization type polyacrylic acid, the polyacrylic acid that incomplete neutralization type polyacrylic acid is partly neutralized, polyacrylic acid
Carbomer is, cross-linking regulator selects tartaric acid, and tackifier select polyvinylpyrrolidone and sodium cellulose glycolate, complexing agent
From disodium ethylene diamine tetraacetate.
In the above-mentioned technical solutions, it is preferable that the weight ratio of each component of the defervescence plaster used matrix is：It is described endless
Full neutralization type polyacrylic acid is 4.5 parts, and the polyvinylpyrrolidone is 1 part, and the sodium cellulose glycolate is 3 parts, described
Propane diols is 40 parts, and the Dihydroxyaluminium Aminoacetate is 0.07 part, and the tartaric acid is 0.7 part.
In the technical scheme, defervescence plaster used matrix is a kind of catablasm base material, wherein in the weight ratio of each component, no
Complete neutralization type polyacrylic acid is 4.5 parts, and the polyvinylpyrrolidone is 1 part, and the sodium cellulose glycolate is 3 parts, institute
Propane diols is stated as 40 parts, the Dihydroxyaluminium Aminoacetate is 0.07 part, and the tartaric acid is 0.7 part, using made of the weight ratio bars
Cloth agent matrix, the medicinal effects to bupleurum Chinense volatile oil and paracetamol can be strengthened.
In the above-mentioned technical solutions, it is preferable that above-mentioned that bringing down a fever for preparation is combined by paracetamol and bupleurum Chinense volatile oil
In patch, the back lining materials are non-woven fabrics, and the lid lining material is transparent polypropylene film.
In the technical scheme, the defervescence plaster used matrix for including paracetamol and bupleurum Chinense volatile oil is coated on backing material
On material, then covered by lid lining material, improve defervescence plaster used property easy to use.Wherein, back lining materials and lid lining material and coating
Technique is prior art, be will not be repeated here.
Present invention also offers a kind of defervescence plaster used preparation method, applied to in above-mentioned technical proposal by acetyl ammonia
Defervescence plaster used preparation prepared by base phenol and bupleurum Chinense volatile oil combination, including：Radix bupleuri traditional Chinese medicine powder is broken into fine powder, crosses 20-40 mesh
Sieve；Using sieved radix bupleuri fine powder, bupleurum Chinense volatile oil is prepared；First permeation enhancers, the second permeation enhancers and the radix bupleuri are waved
Hair oil mixes and is used as A phases；The Polymer Solution of cross-linked scaffold material and tackifier is mixed as B phases；By cross-linking regulator and
Complexing agent in pure water stirring and dissolving as C phases；Using paracetamol, desensitizer and antioxidant add pure water stirring and dissolving as
D phases；First permeation enhancers are stirred with crosslinking agent and are placed in as E phases in vacuum equipment；Successively respectively to described true
A phase, B phase, C phase is added in null device and is stirred mixing with D phases；Sheet is made using calendering rubbing method after well mixed, and
Pack.
In the technical scheme, it is 20-40 targeted fine powders first to crush Radix Bupleuri, and radix bupleuri volatilization is prepared using fine powder
Oil, bupleurum Chinense volatile oil will be added in the first permeation enhancers and the second permeation enhancers, as A phases, by cross-linked scaffold material and thickening
The mixed solution of the Polymer Solution of agent, will be to second using the solvent soln of cross-linking regulator and complexing agent as C phases as B phases
Acylamino- phenol and desensitizer, the solvent soln of antioxidant are used as D phases after stirring, and the first permeation enhancers and crosslinking agent are mixed
E phases are used as afterwards, E phases are inserted in vacuum equipment, and add A phases and B phases into vacuum equipment respectively successively, are stirred mixed
Close, then add C phases and D phases into vacuum equipment respectively, seal vacuum equipment, and extract the gas in vacuum equipment, by A
Phase, B phases, C phases, D phases and E phases stir certain time with certain speed, complete to be mixed with each component, and will mix equal
Even material prepares slabbing using calendering rubbing method, is formed defervescence plaster used.
In the above-mentioned technical solutions, it is preferable that the preparation method of bupleurum Chinense volatile oil specifically includes：Radix bupleuri fine powder is added permanent
Soaked in the water of 37 ± 0.5 DEG C of temperature；Add radix bupleuri fine powder water in add extracellular proteinase, cellulase, hemicellulase,
The microbial culture medium of the extracellular biology enzyme such as pectase and ligninase；The liquid for adding radix bupleuri fine powder and microbial culture medium is existed
Stir 48 hours and fermented under temperature constant state；The Chinese medicine extract obtained after filtering fermentation liquor is subjected to steam distillation, obtained
To bupleurum Chinense volatile oil.
In the technical scheme, the cell membrane of radix bupleuri fine powder is destroyed using extracellular biology enzyme, makes having in radix bupleuri
Effect composition can be extracted, and constant temperature stirring improves enzymolysis of the microorganism to radix bupleuri, while by radix bupleuri
Active ingredient dissolves in the solution, carries out steam distillation to solution, radix bupleuri extracts active ingredients therein are come out, obtain bavin
Hu volatile oil.
In the above-mentioned technical solutions, it is preferable that the speed being stirred to the material in the vacuum equipment is per minute
100 turns, mixing time is 45 minutes.
In the technical scheme, after A phase, B phase, C phase, D phases and E are added into vacuum equipment, with 100r/min speed
Degree stirring 45 minutes, while material is well mixed so that material is sticky enough, and calendering rubbing method can be used to enter traveling one
Step operation.
In the above-mentioned technical solutions, it is preferable that described mix the Polymer Solution of cross-linked scaffold material and tackifier is made
Specifically included for B phases：The cross-linked scaffold material and the tackifier are inserted in container respectively, add appropriate amount of purified water；Put
Putting certain time makes it fully be swelled, and heats and stirs, using the Polymer Solution to stir as B phases.
In the technical scheme, cross-linked scaffold material and tackifier are added in container, addition can fully be swelled material
Pure water, do not stir, standing overnight makes it fully be swelled, and material is heated after abundant swelling, stirs, will stir simultaneously
Uniform Polymer Solution is mixed as B phases.
In the above-mentioned technical solutions, it is preferable that it is described it is well mixed after sheet be made using calendering rubbing method specifically included：
Well mixed material is coated on back lining materials using rubbing method is rolled；Lid lining material is covered on back lining materials and is coated with
There is the side of material；Lid lining material after fitting and back lining materials are cut into a certain size sheet.
Compared with prior art, beneficial effects of the present invention are：The preferable Western medicine of effect is brought down a fever to acetyl ammonia by selecting
A kind of the defervescence plaster used of external application is prepared in base phenol and anti-inflammatory, the volatile oil combination of antipyretic bupleurum Chinese, reduces oral drugs pair
Intestines and stomach cause the possibility of uncomfortable reaction and the infringement to liver kidney, extend the duration of bringing down a fever, enhance effect of bringing down a fever.
Brief description of the drawings
Fig. 1 is the schematic flow diagram of preparation method defervescence plaster used disclosed in an embodiment of the present invention.
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with the embodiment of the present invention
In accompanying drawing, the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is
The part of the embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, ordinary skill people
The every other embodiment that member is obtained on the premise of creative work is not made, belongs to the scope of protection of the invention.
The present invention is described in further detail below in conjunction with the accompanying drawings：
According to it is provided by the invention it is a kind of by paracetamol and bupleurum Chinense volatile oil combine prepare it is defervescence plaster used, including：
50~400 milligrams of paracetamol, 0.5~1.0 microlitre of bupleurum Chinense volatile oil and defervescence plaster used matrix；The acetparaminosalol
Phenol and the bupleurum Chinense volatile oil mix with the defervescence plaster used matrix, and by the mixed defervescence plaster used substrate application described
Between back lining materials and the lid lining material；Wherein, the bupleurum Chinense volatile oil is that the radix bupleuri after biological enzymolysis is extracted using distillation
Volatile oil.
In this embodiment, from the preferable Western medicine paracetamol of effect of bringing down a fever and anti-inflammatory, antipyretic bupleurum Chinese
Volatile oil combination prepare a kind of the defervescence plaster used of external application, reduce oral drugs and intestines and stomach caused with uncomfortable react and to liver kidney
Infringement possibility, extend the duration of bringing down a fever, enhance effect of bringing down a fever.
Wherein, biological enzymolysis is carried out to bupleurum Chinese using extracellular biology enzyme, the cell membrane of radix bupleuri is destroyed, improved
Extraction to active ingredient in Radix Bupleuri.The radix bupleuri solution containing active ingredient extracted is subjected to distillation extraction again,
Purer bupleurum Chinense volatile oil is obtained, improves the effect of bringing down a fever of radix bupleuri.
Specifically, often paste the defervescence plaster used paracetamol for including 50~400 milligrams and 0.5~1.0 microlitre of radix bupleuri
Volatile oil, Chinese medicine and Western medicine act to human body jointly, improve defervescence plaster used effect of bringing down a fever.
In the above embodiment, it is preferable that above-mentioned combine the defervescence plaster used of preparation by paracetamol and bupleurum Chinense volatile oil
Also include defervescence plaster used matrix, defervescence plaster used matrix includes：First permeation enhancers, the second permeation enhancers, desensitizer, antioxidant, crosslinking
Agent, cross-linked scaffold material, cross-linking regulator, tackifier and complexing agent, the first permeation enhancers and the second permeation enhancers are used to improve
The skin permeability of paracetamol, crosslinking agent and cross-linking regulator are used for the crosslinking for promoting cross-linked scaffold material.
In this embodiment, using defervescence plaster used matrix, paracetamol and bupleurum Chinense volatile oil are blended in defervescence plaster used base
To produce medicine effect to human body in matter, wherein, the first permeation enhancers and the second permeation enhancers are used to improve paracetamol
Skin permeability, promote the active ingredient in medicine to infiltrate through skin, crosslinking agent and cross-linking regulator are used to promote crosslinking bone
The crosslinking of frame material, desensitizer are used to reduce allergic reaction of the skin to medicine, and antioxidant is used to strengthening defervescence plaster used matrix and right
The inoxidizability of Paracetamol and bupleurum Chinense volatile oil, tackifier and complexing agent are used for defervescence plaster used matrix, paracetamol
With the harmony of bupleurum Chinense volatile oil composition, strengthen the viscosity of defervescence plaster used matrix, so as to ensure defervescence plaster used normal use.
In the above embodiment, it is preferable that the first permeation enhancers include menthol and azone, the second permeation enhancers are the third two
Alcohol, desensitizer are promethazine hydrochloride, and antioxidant is sodium sulfite, and crosslinking agent is Dihydroxyaluminium Aminoacetate, during cross-linked scaffold material is incomplete
With type polyacrylic acid NP700, cross-linking regulator is tartaric acid, and tackifier include polyvinylpyrrolidone PVPK90 and methylol is fine
Plain sodium CMC-Na is tieed up, complexing agent is disodium ethylene diamine tetraacetate EDTA-2Na.
In this embodiment, the first permeation enhancers select menthol and water-solubleazone, and the second permeation enhancers are from the third two
Alcohol, desensitizer select promethazine hydrochloride, and antioxidant selects sodium sulfite, and crosslinking agent selects Dihydroxyaluminium Aminoacetate, cross-linked scaffold material selection
Incomplete neutralization type polyacrylic acid NP700, the polyacrylic acid that incomplete neutralization type polyacrylic acid NP700 is partly neutralized
NP700, polyacrylic acid NP700 are also carbomer, and cross-linking regulator selects tartaric acid, and tackifier select polyvinylpyrrolidone
PVPK90 and sodium cellulose glycolate CMC-Na, complexing agent select disodium ethylene diamine tetraacetate EDTA-2Na.
In the above embodiment, it is preferable that the weight ratio of each component of defervescence plaster used matrix is：Incomplete neutralization type gathers
Acrylic acid NP700 is 4.5 parts, and polyvinylpyrrolidone PVPK90 is 1 part, and sodium cellulose glycolate CMC-Na is 3 parts, propane diols
For 40 parts, Dihydroxyaluminium Aminoacetate is 0.07 part, and tartaric acid is 0.7 part.
In this embodiment, defervescence plaster used matrix is a kind of catablasm base material, endless wherein in the weight ratio of each component
Full neutralization type polyacrylic acid NP700 is 4.5 parts, and polyvinylpyrrolidone PVPK90 is 1 part, and sodium cellulose glycolate CMC-Na is
3 parts, propane diols is 40 parts, and Dihydroxyaluminium Aminoacetate is 0.07 part, and tartaric acid is 0.7 part, using cataplasm base made of the weight ratio
Matter, the medicinal effects to bupleurum Chinense volatile oil and paracetamol can be strengthened.
Specifically, applied using the defervescence plaster used matrix for rolling rubbing method and being blended with paracetamol and bupleurum Chinense volatile oil
Cloth is often pasted no more than 10 grams when on back lining materials according to the component content of defervescence plaster used matrix made of aforementioned proportion.
In the above embodiment, it is preferable that above-mentioned combine the defervescence plaster used of preparation by paracetamol and bupleurum Chinense volatile oil
In, back lining materials are non-woven fabrics, and lid lining material is transparent polypropylene film.
In this embodiment, the defervescence plaster used matrix for including paracetamol and bupleurum Chinense volatile oil is coated on back lining materials
On, then covered by lid lining material, improve defervescence plaster used property easy to use.Wherein, back lining materials and lid lining material and coating work
Skill is prior art, be will not be repeated here.
As shown in figure 1, present invention also offers a kind of defervescence plaster used preparation method, applied to in above-described embodiment by
Defervescence plaster used preparation prepared by paracetamol and bupleurum Chinense volatile oil combination, including：Step S101, radix bupleuri Chinese medicine is crushed
Into fine powder, 20-40 mesh sieves are crossed；Step S102, using sieved radix bupleuri fine powder, prepare bupleurum Chinense volatile oil；Step S103, by first
Permeation enhancers, the second permeation enhancers and bupleurum Chinense volatile oil mix and are used as A phases；Step S104, by cross-linked scaffold material and tackifier
Polymer Solution mixing be used as B phases；Step S105, using cross-linking regulator and complexing agent in pure water stirring and dissolving as C phases；
Step S106, paracetamol, desensitizer and antioxidant are added into pure water stirring and dissolving as D phases；Step S107, first is promoted
Bleeding agent is stirred with crosslinking agent and is placed in as E phases in vacuum equipment；Step S108, is added into vacuum equipment respectively successively
A phase, B phase, C phase is stirred mixing with D phases；Step S109, use calendering rubbing method that sheet is made after well mixed, and seal
Packaging.
In this embodiment, it is 20-40 targeted fine powders first to crush Radix Bupleuri, and radix bupleuri volatilization is prepared using fine powder
Oil, bupleurum Chinense volatile oil will be added in the first permeation enhancers and the second permeation enhancers, as A phases, by cross-linked scaffold material and thickening
The mixed solution of the Polymer Solution of agent, will be to second using the solvent soln of cross-linking regulator and complexing agent as C phases as B phases
Acylamino- phenol and desensitizer, the solvent soln of antioxidant are used as D phases after stirring, and the first permeation enhancers and crosslinking agent are mixed
E phases are used as afterwards, E phases are inserted in vacuum equipment, and add A phases and B phases into vacuum equipment respectively successively, are stirred mixed
Close, then add C phases and D phases into vacuum equipment respectively, seal vacuum equipment, and extract the gas in vacuum equipment, by A
Phase, B phases, C phases, D phases and E phases stir certain time with certain speed, complete to be mixed with each component, and will mix equal
Even material prepares slabbing using calendering rubbing method, is formed defervescence plaster used.
Wherein, the defervescence plaster used size of sheet is specifically set according to the concrete practice situation of the present invention, it is preferable that setting is moved back
The size of heat posted is 12 × 5 centimetres or 10 × 15 centimetres.
In the above embodiment, it is preferable that the preparation method of bupleurum Chinense volatile oil specifically includes：Radix bupleuri fine powder is added into constant temperature
Soaked in 37 ± 0.5 DEG C of water；Extracellular proteinase, cellulase, hemicellulase, fruit are added in the water for adding radix bupleuri fine powder
The microbial culture medium of the extracellular biology enzyme such as glue enzyme and ligninase；The liquid of radix bupleuri fine powder and microbial culture medium will be added in perseverance
Stir 48 hours and fermented under temperature state；The Chinese medicine extract obtained after filtering fermentation liquor is subjected to steam distillation, obtained
Bupleurum Chinense volatile oil.
In this embodiment, the cell membrane of radix bupleuri fine powder is destroyed using extracellular biology enzyme, made effective in radix bupleuri
Composition can be extracted, and constant temperature stirring improves enzymolysis of the microorganism to radix bupleuri, while by having in radix bupleuri
Imitate composition dissolving in the solution, steam distillation is carried out to solution, radix bupleuri extracts active ingredients therein are come out, obtain radix bupleuri
Volatile oil.
In the above embodiment, it is preferable that the speed being stirred to the material in vacuum equipment is 100 turns per minute,
Mixing time is 45 minutes.
In this embodiment, after A phase, B phase, C phase, D phases and E are added into vacuum equipment, with 100r/min speed
Stirring 45 minutes, while material is well mixed so that material is sticky enough, calendering rubbing method can be used to carry out further
Operation.
Have in the above embodiment, it is preferable that cross-linked scaffold material is mixed as B phases with the Polymer Solution of tackifier
Body includes：Cross-linked scaffold material and tackifier are inserted in container respectively, add appropriate amount of purified water；Placing certain time fills it
Divide swelling, heat and stir, using the Polymer Solution to stir as B phases.
In this embodiment, cross-linked scaffold material and tackifier are added in container, addition can fully be swelled material
Pure water, do not stir, standing overnight makes it fully be swelled, and material is heated after abundant swelling, stirs, will stir simultaneously
Uniform Polymer Solution is as B phases.
Specifically included in the above embodiment, it is preferable that sheet is made using calendering rubbing method after well mixed：Will mixing
Uniform material is coated on back lining materials using rubbing method is rolled；Lid lining material is covered on back lining materials and is coated with material
Side；Lid lining material after fitting and back lining materials are cut into a certain size sheet.
What is proposed in above-described embodiment combines the defervescence plaster used of preparation by paracetamol and bupleurum Chinense volatile oil, is using
Cheng Zhong, forehead or temple are pasted on, neck Dazhui acupoint can also be sticked on.Daily 1~2, often paste the up time 8~
12 hours.Component percutaneous dosing (treatment) system in defervescence plaster used, has that clearing heat and detoxicating, to deliver cold dispelling, arousing brain, raising spirit, analgesic anti-
The effect of bacterium and enhancing immunity of organisms, heating, myalgia caused by a variety of causes can be effectively dispelled, it is evident in efficacy, move back
It is fast to burn speed, treats both principal and secondary aspect of disease, meanwhile, without stomach, avoiding inadaptable and liver the head of stomach should act on drug absorption,
During drug absorption is brought down a fever, endo-medicine can be effectively avoided to damage the possibility of stomach liver.
During carrying out experimental verification to medicine in laboratory, using rabbit as experimental subjects, using defervescence plaster used to dry ferment
The fever phenomenon of rabbit caused by mother is studied, and experiment process is as follows：
Take rabbit to push away the hair for rejecting rabbit using electricity, and raised 7 days in (22 ± 2) DEG C laboratory, 8 points of every morning
Anus temperature is surveyed with afternoon 2 times, continuous 4 days at 4 points.Starting fasting 12 hours before testing, free water, morning next day surveys anus temperature 2 times,
Every 1 hour, average as normal body temperature.Choose the temperature difference twice and be no more than 0.3 DEG C, family of the mean body temperature at 36.6~38.3 DEG C
Rabbit 38, rabbit is randomly divided into Normal group 12 and modeling group 26.To the rabbit dorsal sc injection of modeling group
20% staphylococcus aureus 10mL/kg, the Normal group injection sodium chloride injection of equivalent 0.9%.After pyrogenicity 6 hours, body temperature is taken
More than 0.8 DEG C of rabbit 16 of rise, it is randomly divided into 2 groups (2% paracetamol groups, defervescence plaster used group), paracetamol
Group gives 2% paracetamol gastric infusion, Normal group physiological saline gastric infusion；Defervescence plaster used group of rabbit back patch of being in
Apply defervescence plaster used.1 after medicine, respectively survey anus temperature 1 time within 2,3,5 hours, using normal body temperature as radix, calculate the change of each time point rabbit body temperature
Change value (△ DEG C).
After administration after 3 hours, defervescence plaster used have notable refrigeration function to fever in rabbits caused by dry ferment, action intensity with it is right
Paracetamol is suitable, and with action time it is longer the characteristics of；5h after administration, defervescence plaster used compared with control group, rabbit body temperature
Change has general significant difference (P<0.05), paracetamol group rabbit body temperature compared with blank control group declines without statistics
Meaning is learned, is shown in Table 1.
The defervescence plaster used influence (n=10) to the rabbit body temperature that generated heat caused by dry ferment of table 1
Note：Compared with control group, * P ＜ 0.05, * * P ＜ 0.01.
Described above is embodiments of the present invention, it is contemplated that oral antipyretic causes discomfort to intestines and stomach in the prior art
Reaction and the infringement to liver kidney, and the technical problem that the duration of bringing down a fever is short, the present invention propose one kind by acetparaminosalol
Defervescence plaster used and its preparation method prepared by phenol and bupleurum Chinense volatile oil combination, from the preferable Western medicine paracetamol of effect of bringing down a fever
A kind of the defervescence plaster used of external application is prepared in volatile oil combination with anti-inflammatory, antipyretic bupleurum Chinese, reduces oral drugs to stomach and intestine
Road causes the possibility of uncomfortable reaction and the infringement to liver kidney, extends the duration of bringing down a fever, enhances effect of bringing down a fever.
The preferred embodiments of the present invention are these are only, are not intended to limit the invention, for those skilled in the art
For member, the present invention can have various modifications and variations.Any modification within the spirit and principles of the invention, being made,
Equivalent substitution, improvement etc., should be included in the scope of the protection.
Claims (10)
1. a kind of combine the defervescence plaster used of preparation, including back lining materials and lid lining material by paracetamol and bupleurum Chinense volatile oil,
Characterized in that, also include：
50~400 milligrams of paracetamol, 0.5~1.0 microlitre of bupleurum Chinense volatile oil and defervescence plaster used matrix；
The paracetamol and the bupleurum Chinense volatile oil mix with the defervescence plaster used matrix, and described are moved back mixed
Heat posted substrate application is between the back lining materials and the lid lining material；
Wherein, the bupleurum Chinense volatile oil is that the radix bupleuri after biological enzymolysis utilizes the volatile oil for distilling extraction.
2. according to claim 1 combine the defervescence plaster used of preparation by paracetamol and bupleurum Chinense volatile oil, its feature exists
In：
The defervescence plaster used matrix includes：First permeation enhancers, the second permeation enhancers, desensitizer, antioxidant, crosslinking agent, crosslinking bone
Frame material, cross-linking regulator, tackifier and complexing agent, first permeation enhancers and second permeation enhancers are used for raising pair
The skin permeability of Paracetamol, the crosslinking agent and the cross-linking regulator are used for the friendship for promoting the cross-linked scaffold material
Connection.
3. according to claim 2 combine the defervescence plaster used of preparation by paracetamol and bupleurum Chinense volatile oil, its feature exists
In first permeation enhancers include menthol and azone, and second permeation enhancers are propane diols, and the desensitizer is hydrochloric acid
Fenazil, the antioxidant are sodium sulfite, and the crosslinking agent is Dihydroxyaluminium Aminoacetate, and the cross-linked scaffold material is incomplete neutralization type
Polyacrylic acid, the cross-linking regulator are tartaric acid, and the tackifier include polyvinylpyrrolidone and sodium cellulose glycolate,
The complexing agent is disodium ethylene diamine tetraacetate.
4. according to claim 3 combine the defervescence plaster used of preparation by paracetamol and bupleurum Chinense volatile oil, its feature exists
In the weight ratio of each component of the defervescence plaster used matrix is：
The not exclusively neutralization type polyacrylic acid is 4.5 parts, and the polyvinylpyrrolidone is 1 part, the hydroxymethyl cellulose
Sodium is 3 parts, and the propane diols is 40 parts, and the Dihydroxyaluminium Aminoacetate is 0.07 part, and the tartaric acid is 0.7 part.
5. prepared by being combined by paracetamol and bupleurum Chinense volatile oil according to any one of claim 1-4 brings down a fever
Patch, it is characterised in that the back lining materials are non-woven fabrics, and the lid lining material is transparent polypropylene film.
6. a kind of defervescence plaster used preparation method, applied to any one of claim 2 to 5 by paracetamol and bavin
The combination of Hu volatile oil prepares defervescence plaster used, it is characterised in that including：
Radix bupleuri traditional Chinese medicine powder is broken into fine powder, crosses 20-40 mesh sieves；
Using sieved radix bupleuri fine powder, bupleurum Chinense volatile oil is prepared；
First permeation enhancers, the second permeation enhancers and the bupleurum Chinense volatile oil are mixed as A phases；
The Polymer Solution of cross-linked scaffold material and tackifier is mixed as B phases；
Using cross-linking regulator and complexing agent in pure water stirring and dissolving as C phases；
Paracetamol, desensitizer and antioxidant are added into pure water stirring and dissolving as D phases；
First permeation enhancers are stirred with crosslinking agent and are placed in as E phases in vacuum equipment；
Add A phase, B phase, C phase into the vacuum equipment respectively successively and be stirred mixing with D phases；
Sheet is made using calendering rubbing method after well mixed, and packed.
7. defervescence plaster used preparation method according to claim 6, it is characterised in that the preparation method of the bupleurum Chinense volatile oil
Specifically include：
Radix bupleuri fine powder is added in the water of 37 ± 0.5 DEG C of constant temperature and soaked；
The born of the same parents such as extracellular proteinase, cellulase, hemicellulase, pectase and ligninase are added in the water for adding radix bupleuri fine powder
The microbial culture medium of outer biology enzyme；
The liquid for adding radix bupleuri fine powder and microbial culture medium is stirred 48 hours under temperature constant state and fermented；
The Chinese medicine extract obtained after filtering fermentation liquor is subjected to steam distillation, obtains bupleurum Chinense volatile oil.
8. defervescence plaster used preparation method according to claim 6, it is characterised in that enter to the material in the vacuum equipment
The speed of row stirring is 100 turns per minute, and mixing time is 45 minutes.
9. defervescence plaster used preparation method according to claim 6, it is characterised in that described by cross-linked scaffold material and thickening
The Polymer Solution mixing of agent specifically includes as B phases：
The cross-linked scaffold material and the tackifier are inserted in container respectively, add appropriate amount of purified water；
Placing certain time makes it fully be swelled, and heats and stirs, using the Polymer Solution to stir as B phases.
10. defervescence plaster used preparation method according to claim 6, it is characterised in that it is described it is well mixed after using calendering
Rubbing method is made sheet and specifically included：
Well mixed material is coated on back lining materials using rubbing method is rolled；
Lid lining material is covered in the side that material is coated with back lining materials；
Lid lining material after fitting and back lining materials are cut into a certain size sheet.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108578477A (en) * | 2018-06-19 | 2018-09-28 | 吉林百年汉克制药有限公司 | A kind of Compound injection of paracetamol pharmaceutical composition and its preparation method and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872173A (en) * | 2012-10-22 | 2013-01-16 | 济南百鸣生物制药有限公司 | Compound acetaminophen orally disintegrating tablet for beasts and birds and preparation method for compound acetaminophen orally disintegrating tablet |
| CN105878315A (en) * | 2016-05-31 | 2016-08-24 | 四川德培源中药科技开发有限公司 | Radix bupleuri fever cooling patch and preparation technology thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872173A (en) * | 2012-10-22 | 2013-01-16 | 济南百鸣生物制药有限公司 | Compound acetaminophen orally disintegrating tablet for beasts and birds and preparation method for compound acetaminophen orally disintegrating tablet |
| CN105878315A (en) * | 2016-05-31 | 2016-08-24 | 四川德培源中药科技开发有限公司 | Radix bupleuri fever cooling patch and preparation technology thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108578477A (en) * | 2018-06-19 | 2018-09-28 | 吉林百年汉克制药有限公司 | A kind of Compound injection of paracetamol pharmaceutical composition and its preparation method and application |
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