CN107583036A - A kind of recombinant human interferon alpha 1 b vaginal expansion plug and preparation method thereof - Google Patents
A kind of recombinant human interferon alpha 1 b vaginal expansion plug and preparation method thereof Download PDFInfo
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- CN107583036A CN107583036A CN201711059492.1A CN201711059492A CN107583036A CN 107583036 A CN107583036 A CN 107583036A CN 201711059492 A CN201711059492 A CN 201711059492A CN 107583036 A CN107583036 A CN 107583036A
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- 108010002492 human interferon alfa-1b Proteins 0.000 title claims abstract description 61
- 102000000707 human interferon alfa-1b Human genes 0.000 title claims abstract description 61
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- 229930195729 fatty acid Natural products 0.000 claims 2
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
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- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 4
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- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 description 2
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- MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 1
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- 235000008777 kaempferol Nutrition 0.000 description 1
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- UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Numbering | Axial expansion value | It is radially expanded value | Weight differential |
Embodiment 1 | 1.92 | 1.91 | ± 0.02% |
Embodiment 2 | 1.88 | 1.87 | ± 0.13% |
Embodiment 3 | 1.87 | 1.88 | ± 0.12% |
Embodiment 4 | 1.82 | 1.84 | ± 0.27% |
Embodiment 5 | 1.82 | 1.82 | ± 0.25% |
Embodiment 6 | 1.79 | 1.80 | ± 0.28% |
Numbering | 4℃ | 25℃ | 37℃ |
Embodiment 1 | 5.1×108 | 3.6×108 | 1.7×108 |
Embodiment 2 | 4.9×108 | 3.1×108 | 8.4×107 |
Embodiment 3 | 4.9×108 | 2.9×108 | 8.5×107 |
Embodiment 4 | 4.7×108 | 2.2×108 | 7.8×107 |
Embodiment 5 | 4.8×108 | 2.0×108 | 7.8×107 |
Embodiment 6 | 4.4×108 | 1.8×108 | 7.1×107 |
Comparative example 1 | 3.7×107 | 2.9×104 | 5.5×102 |
Comparative example 2 | 4.0×107 | 3.5×104 | 5.0×102 |
Comparative example 3 | 2.5×108 | 6.3×107 | 1.0×107 |
Comparative example 4 | 2.8×108 | 7.2×107 | 2.1×107 |
Comparative example 5 | 3.8×108 | 1.0×108 | 9.2×107 |
Comparative example 6 | 3.6×108 | 1.2×108 | 9.5×107 |
Numbering | Release time (h) |
Embodiment 1 | 24 |
Embodiment 2 | 20 |
Embodiment 3 | 20 |
Embodiment 4 | 18 |
Embodiment 5 | 18 |
Embodiment 6 | 20 |
Comparative example 1 | 4 |
Comparative example 2 | 10 |
Antibacterial circle diameter (mm) | Susceptibility |
More than 20 | It is extremely quick |
15-20 | Gao Min |
10-14 | In it is quick |
1-10 | Muting sensitive |
0 | It is unwise |
Numbering | Bacterial concentration (cfu/g) | Antibacterial circle diameter (mm) | Susceptibility |
Embodiment 1 | 105-106 | 27.20 | It is extremely quick |
Embodiment 2 | 105-106 | 26.72 | It is extremely quick |
Embodiment 3 | 105-106 | 25.26 | It is extremely quick |
Embodiment 4 | 105-106 | 25.17 | It is extremely quick |
Embodiment 5 | 105-106 | 24.88 | It is extremely quick |
Embodiment 6 | 105-106 | 24.26 | It is extremely quick |
Comparative example 3 | 105-106 | 14.13 | In it is quick |
Comparative example 4 | 105-106 | 11.36 | In it is quick |
Claims (10)
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CN201711059492.1A CN107583036B (en) | 2017-11-01 | 2017-11-01 | Recombinant human interferon α 1b vaginal expansion suppository and preparation method thereof |
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CN201711059492.1A CN107583036B (en) | 2017-11-01 | 2017-11-01 | Recombinant human interferon α 1b vaginal expansion suppository and preparation method thereof |
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Publication Number | Publication Date |
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CN107583036A true CN107583036A (en) | 2018-01-16 |
CN107583036B CN107583036B (en) | 2020-04-24 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108403618A (en) * | 2018-04-26 | 2018-08-17 | 霍尔果斯汉智医药科技有限公司 | A kind of imiquimod vaginal expansion plug and preparation method thereof |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1291502A (en) * | 1999-10-11 | 2001-04-18 | 常毅坚 | A Chinese medicinal pill for treating gynecological diseases |
CN101313904A (en) * | 2007-06-01 | 2008-12-03 | 北京德众万全药物技术开发有限公司 | Fenticonazole suppository for treating exterior colpitis |
CN103520264A (en) * | 2013-10-11 | 2014-01-22 | 哈尔滨欧替药业有限公司 | Fukang expandable vaginal suppository, and preparation method and detection method thereof |
CN103751098A (en) * | 2013-12-31 | 2014-04-30 | 哈尔滨欧替药业有限公司 | Recombinant human interferon alpha 2a vaginal expansion suppository and preparation and detection methods thereof |
CN104352667A (en) * | 2014-11-17 | 2015-02-18 | 刘岚 | Medicine for treating nonspecific vaginitis and preparation method |
CN105012938A (en) * | 2015-06-30 | 2015-11-04 | 哈尔滨欧替药业有限公司 | Recombinant human interferon alpha2b vagina expansive suppository, and preparation method and detection method thereof |
CN106692788A (en) * | 2017-03-01 | 2017-05-24 | 秦玉成 | External medicine for treating gynecological diseases |
-
2017
- 2017-11-01 CN CN201711059492.1A patent/CN107583036B/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1291502A (en) * | 1999-10-11 | 2001-04-18 | 常毅坚 | A Chinese medicinal pill for treating gynecological diseases |
CN101313904A (en) * | 2007-06-01 | 2008-12-03 | 北京德众万全药物技术开发有限公司 | Fenticonazole suppository for treating exterior colpitis |
CN103520264A (en) * | 2013-10-11 | 2014-01-22 | 哈尔滨欧替药业有限公司 | Fukang expandable vaginal suppository, and preparation method and detection method thereof |
CN103751098A (en) * | 2013-12-31 | 2014-04-30 | 哈尔滨欧替药业有限公司 | Recombinant human interferon alpha 2a vaginal expansion suppository and preparation and detection methods thereof |
CN104352667A (en) * | 2014-11-17 | 2015-02-18 | 刘岚 | Medicine for treating nonspecific vaginitis and preparation method |
CN105012938A (en) * | 2015-06-30 | 2015-11-04 | 哈尔滨欧替药业有限公司 | Recombinant human interferon alpha2b vagina expansive suppository, and preparation method and detection method thereof |
CN106692788A (en) * | 2017-03-01 | 2017-05-24 | 秦玉成 | External medicine for treating gynecological diseases |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108403618A (en) * | 2018-04-26 | 2018-08-17 | 霍尔果斯汉智医药科技有限公司 | A kind of imiquimod vaginal expansion plug and preparation method thereof |
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Effective date of registration: 20211116 Address after: 150040 office building 7, Bohai Third Road, haping road concentration area, Harbin Economic Development Zone, Harbin, Heilongjiang Province Patentee after: Harbin Tianmei Pharmaceutical Co.,Ltd. Address before: 150069 No. 7, Bohai Third Road, Pingfang Industrial Zone, economic and Technological Development Zone, Harbin, Heilongjiang Province Patentee before: HARBIN OT PHARMACEUTICALS Co.,Ltd. Patentee before: Qiu Mingshi |
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Denomination of invention: A recombinant human interferon a 1b vaginal expansion suppository and its preparation method Effective date of registration: 20230704 Granted publication date: 20200424 Pledgee: Harbin Kechuang Financing Guarantee Co.,Ltd. Pledgor: Harbin Tianmei Pharmaceutical Co.,Ltd. Registration number: Y2023230000060 |
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Granted publication date: 20200424 Pledgee: Harbin Kechuang Financing Guarantee Co.,Ltd. Pledgor: Harbin Tianmei Pharmaceutical Co.,Ltd. Registration number: Y2023230000060 |
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Denomination of invention: A recombinant human interferon alpha 1b vaginal dilation plug and its preparation method Granted publication date: 20200424 Pledgee: Harbin Kechuang Financing Guarantee Co.,Ltd. Pledgor: Harbin Tianmei Pharmaceutical Co.,Ltd. Registration number: Y2024230000040 |
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