CN107582221B - For treating the device of nasosinusitis and expansion nasal sinus opening - Google Patents

For treating the device of nasosinusitis and expansion nasal sinus opening Download PDF

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Publication number
CN107582221B
CN107582221B CN201710545351.4A CN201710545351A CN107582221B CN 107582221 B CN107582221 B CN 107582221B CN 201710545351 A CN201710545351 A CN 201710545351A CN 107582221 B CN107582221 B CN 107582221B
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CN
China
Prior art keywords
main body
sinus
nasal sinus
opening
nasosinusitis
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Active
Application number
CN201710545351.4A
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Chinese (zh)
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CN107582221A (en
Inventor
金秉壮
申衡徹
柳荣武
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Mei Jia Medical Co Ltd
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Mei Jia Medical Co Ltd
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Publication of CN107582221A publication Critical patent/CN107582221A/en
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M29/00Dilators with or without means for introducing media, e.g. remedies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602Type of release, e.g. controlled, sustained, slow
    • A61L2300/604Biodegradation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M2025/1043Balloon catheters with special features or adapted for special applications
    • A61M2025/105Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M29/00Dilators with or without means for introducing media, e.g. remedies
    • A61M29/02Dilators made of swellable material
    • A61M2029/025Dilators made of swellable material characterised by the guiding element
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00Anatomical parts of the body
    • A61M2210/06Head
    • A61M2210/0681Sinus (maxillaris)

Abstract

The present invention is provided to treat the device of nasosinusitis and expansion nasal sinus opening, it is free from side effects and is open in nasal sinus biodegradable to human body.In addition, the present invention provides economic and safety the device for treating nasosinusitis and expanding nasal sinus opening.For this purpose, one embodiment of the invention discloses a kind of device for treating nasosinusitis and expanding nasal sinus opening, which includes: main body, is made of the Biodegradable material being decomposed after the 1st set time in human body;And the therapeutic agent of paranasal sinusitis, it is coated on at least one side of the main body, the main body coated with the therapeutic agent is inflated after being inserted into reduced nasal sinus opening.

Description

For treating the device of nasosinusitis and expansion nasal sinus opening
Technical field
The present invention relates to the devices for treating nasosinusitis and expansion nasal sinus opening.More particularly, to nasal sinus can be opened Mouth expansion, and the biodegradable device for treating nasosinusitis and expanding nasal sinus opening that is open in nasal sinus.
Background technique
Nasal sinus is in the skull being connect and being called the small opening portion of aperture with nasal cavity (nasal canal: nasal tube) Cavity.Each aperture between nasal sinus and nasal cavity is formed and being the bone by being covered by mucous membrane tissue layer.In general, empty Gas by aperture enter nasal sinus in and out of nasal sinus it is externally discharged.In addition, mucus is continued by the mucous membrane internal layer of nasal sinus It is formed, is discharged in nasal cavity by aperture.
Nasosinusitis refers to the general term of the inflammation in more than one nasal sinus.Acute sinusitis may cause tissue Edema can also interfere the normally ventilation via the discharge of aperture and nasal sinus for the moment, is possible to according to the collection degree of mucus Cause the infection in paranasal sinus, is related to the infection of the upper respiratory tract or anaphylactic disease.Chronic nasosinusitis is to cause the chronic sense of nasal sinus Dye and inflammation, the chronicity disease characterized by the reduced or blocking of the duration of more than one nasal sinus aperture.It is chronic Nasosinusitis is usually related with allergic airway disease lasting for a long time, nasal polyp, hypertrophy concha and/or deviation of nasal septum.It is acute Nasosinusitis is by typical single pathogen (for example, the mushroom of the bacterium of a type, the virus of type, type Deng) caused by infection and cause, and chronic nasosinusitis is usually with multiple pathogenic bacterial infections (for example, type more than one is thin Bacterium or the microorganism of the type more than one) it is related.
It, can tissue and/or bone knot to secondary nose anatomical structure in the case where not treating chronic nasosinusitis and shelve Structure brings the damage of unrepairable.Usually using decongestant, steroids nasal mist in the initial therapy of chronic nasosinusitis And drug as antibiotic (in the case where being infected as caused by bacterium).The case where only being can not be restored by drug therapy Under, it will usually it is recommended that surgical intervention.
Acclarent company (Acclarent Inc) where California, USA door Lip river Parker is in order to treat nose Sinusitis and have developed the technology for being called nasal sinus balloon dilatation (Balloon Sinuplasty) TM and for executing the operation System.In the multiple United States Patent (USP)s and patent that U.S. Patent No. No. 7645272, No. 7654997 and No. 7803150 are representative Described in application the various embodiments of nasal sinus balloon dilatation TM operation and used in the execution of such operation it is various Device.In nasal sinus balloon dilatation TM operation, conduit (guide catheter) is inserted into nose, the nasal sinus of morbidity is placed in Aperture in or position adjacent thereto.Then, conducting wire (guidewire) is proceeded in the nasal sinus of morbidity by conduit.It Afterwards, the dilating catheter for having distensible expander (for example, expandable sacculus) is located at morbidity to expander on conducting wire Advance position in the aperture of nasal sinus.Then, expander is extended, without cutting mucous membrane or without removing any bone In the case of, realize the expansion of aperture and the regeneration of the bone adjacent with aperture.Then, conduit and conducting wire are removed, and passes through expansion Aperture and improve the exhaust of the nasal sinus of idiopathy and make its ventilation.
But in such previous method and device, it is difficult to constantly inject drug to the nasal sinus of patient opening, be Injection drug and the conduit used be it is disposable, to be discarded after once perform the operation, although sometimes can be by killing Bacterium reuses identical patient, but most conduit needs discarded, therefore results in waste of resources.
Summary of the invention
The project to be solved
The present invention provides a kind of pair of human body and is free from side effects and is open in nasal sinus biodegradable for treating nasosinusitis And expand the device of nasal sinus opening.
In addition, the present invention provides a kind of economic and safety the device for treating nasosinusitis and expanding nasal sinus opening.
In addition, the invention solves technical task be not limited to technical task mentioned above, those skilled in the art are logical Record below crossing should be clearly understood that in this others not mentioned technical task.
The means to solve the problem
One embodiment of the invention for treat nasosinusitis and expand nasal sinus opening device include: main body, by The Biodegradable material being decomposed after the 1st set time in human body is constituted;And the therapeutic agent of paranasal sinusitis, At least one side coated on the main body, the main body coated with the therapeutic agent are inserted into reduced nasal sinus and are open it After be inflated.
In addition, the main body has columnar eyed structure.
In addition, the main body is made of the suture of elasticity.
In addition, further include film, which surrounds the main body of contraction state, by human body the set the 2nd The Biodegradable material being decomposed after time is constituted, and the 2nd time is shorter than the 1st time.
In addition, further including insertion tube, the main body which is coated with the therapeutic agent is inserted into the quilt The nasal sinus of diminution is open, and the main body is inflated when being discharged from the insertion tube.
In addition, further including foley's tube, the main body which is coated with the therapeutic agent is inserted into institute Reduced nasal sinus opening is stated, the main body is configured to surround the sacculus of the foley's tube, and the main body passes through the ball The expansion of capsule and be inflated.
Invention effect
Of the invention is free from side effects to human body and opens in nasal sinus for treating nasosinusitis and expanding the device that nasal sinus is open Mouth is biodegradable.
In addition, the device economy and safety for treating nasosinusitis and expanding nasal sinus opening of the invention.
In addition, effect of the invention is not limited to effect mentioned above, those skilled in the art can by following record It is expressly understood in this others not mentioned effect.
Detailed description of the invention
Attached drawing below appended by this specification instantiates the preferred embodiment of the present invention, is conducive to and reality of the invention It applies mode to help to understand technical idea of the invention together, but the present invention should not be limited only to item documented by such attached drawing It explains.
Fig. 1 and Fig. 2 shows one embodiment of the invention for treat nasosinusitis and expand nasal sinus opening device it is swollen Swollen front and back.
Fig. 3 and Fig. 4 shows the device for treating nasosinusitis and expansion nasal sinus is open of another embodiment of the present invention.
Fig. 5 is the sectional view for showing nasal sinus opening and being reduced and occur nasosinusitis.
Fig. 6 is to show for the device for being used to treat nasosinusitis and expanding nasal sinus opening of one embodiment of the invention to be applied to The sectional view of nasal sinus opening.
Fig. 7 shows the device for treating nasosinusitis and expansion nasal sinus is open of still another embodiment of the invention.
Fig. 8 is to show the device for being used to treat nasosinusitis and expanding nasal sinus opening of Fig. 7 being applied to cutting for nasal sinus opening Face figure.
Fig. 9 shows the device for treating nasosinusitis and expansion nasal sinus is open of still another embodiment of the invention.
Figure 10 and 11 is to show for the device for being used to treat nasosinusitis and expanding nasal sinus opening of Fig. 9 to be open applied to nasal sinus Sectional view.
The explanation of appended drawing reference
100: main body 200: film
300: insertion tube 400: foley's tube
Specific embodiment
In the following, referring to attached drawing, to a preferred embodiment of the present invention will be described in detail.
The embodiment of the present invention is provided to more completely illustrate the present invention to those skilled in the art, below Embodiment can be deformed into various other forms, and the scope of the present invention is not limited to the following examples.Instead, these embodiments be for The disclosure is provided more and complete and completely transmit thought of the invention to those skilled in the art and provide.
In addition, each structure in attached drawing below for the convenience of explanation property and definition and be greatly exaggerated to show, Identical appended drawing reference refers to identical element in attached drawing.As used in this specification, term " and/or " be included in this and list Project in one and more than one all combinations.
Term used in this specification is to illustrate specific embodiment and use, and does not have to the present invention and limits Effect.
As used in this specification, when singular form not yet explicitly points out other situations in the text, it may include plural Form.In addition, in the present specification, " including (comprise) " and/or " including (comprising) " are to related shape Shape, number, step, movement, the presence of component, element and/or their combination are determined, rather than to exclude more than one Other shapes, number, movement, component, element and/or their combination there is a situation where or it is additional.
Fig. 1 and Fig. 2 shows one embodiment of the invention for treat nasosinusitis and expand nasal sinus opening device it is swollen Swollen front and back.
Referring to FIG. 1 and FIG. 2, one embodiment of the invention includes for treating nasosinusitis and expanding the device that nasal sinus is open Main body 100.
Main body 100 is made of substance biodegradable after the 1st time in human body, although it is not shown, but in table Face is coated with paranasal sinusitis therapeutic agent.
In addition, main body 100 can be open as the substance for having elasticity in nasal sinus expands (expansion), propped up by a kind of elasticity Frame constitutes and nasal sinus can be open and expand.
That is, main body 100 is inserted into nasal sinus opening and is inflated, expanded so that reduced nasal sinus is open, and in institute 1st time of setting is biodegradable later and from human body natural is discharged.
Here, being approximately set to about the 1st time in order to treat nasosinusitis 30 days or so, dropped in main body 100 by biology Paranasal sinusitis therapeutic agent is sustainably put into during solution.Certainly, it can set for the 1st time according to the weight of patient.
Preferably, such main body 100 is constituted by having biodegradable and having elastic suture, is formed as compiling Columnar mesh (mesh) structure knitting suture and being formed.
Here, about the material for forming main body 100 and coated on the paranasal sinusitis therapeutic agent of main body 100, it can be according to trouble The weight of person and be formed as different thickness by a variety of materials, therefore this is omitted and is described in detail.
Fig. 3 and Fig. 4 shows the device for treating nasosinusitis and expansion nasal sinus is open of the other embodiment of the present invention.
Referring to Fig. 3 and Fig. 4, the device packet for treating nasosinusitis and expansion nasal sinus is open of the other embodiment of the present invention Include the film 200 for surrounding main body 100.
Film 200 pressurizes to main body 100 and surrounds, so that main body 100 keeps the shape before expansion.Here, such as Fig. 3 institute Show, film 200 can accordingly be formed with the entire length of main body 100, as shown in figure 4, film (210,220) can also be formed as Only partially surround the both side ends of main body 100.
Such film 200 is made of substance biodegradable after the 2nd time in human body.Here, the 2nd time It is set as the time shorter than the 1st above-mentioned time, preferably, is approximately set within 24 hours.
As film 200 is decomposed, the main body 100 inside film 200 expands as illustrated in fig. 2, so as to be contracted Small nasal sinus, which is open, to be expanded.
Fig. 5 is the sectional view for showing nasal sinus opening and being reduced and occur nasosinusitis, and Fig. 6 is shown an implementation of the invention The device for treating nasosinusitis and expansion nasal sinus opening of example is applied to the sectional view of nasal sinus opening.
Referring to Fig. 5 and Fig. 6, above-mentioned nasal sinus is as the empty sky in the skull for connect with nasal cavity and being covered by mucous membrane Between, it is made of maxillary sinus (MS, jawbone sinus), sinus frontalis (FS, preceding sinus frontalis), sieve sinus (honeycomb), sphenoid sinus (butterfly nest) etc..Such nasal sinus It is arranged in a column (lined with) with the epithelial tissue for generating mucus, forms the state with nasal cavity dredging.Generally, pass through epithelium Tissue and the mucus formed are slowly discharged and being called the opening of paranasal sinus mouth from each paranasal sinus.In these channels, If an epithelial tissue generates inflammation for some reason, intercepted by the cavity that its channel is discharged.It is blocked in this way The state cut can be periodically (constantly generating pain as a result) or chronic.Cause is relevant to the discharge of mucus in this way Obstacle (for example, paranasal sinus mouth is intercepted), can produce mucous membrane in nasal sinus and intercepted showing for (mucosal congestion) As.The chronic mucous membrane of paranasal sinus intercepts the upper belt of phenomenon pair and paranasal sinus side by side to damage, in the future because of partial pressure of oxygen (oxygentension) inflammatory reaction as reduction, microbial reproduction (for example, nasosinusitis, sinusitis) and cause inflammation Disease.
Here, in the present invention, with each opening (1,2) of maxillary sinus MS and sinus frontalis FS is reduced (intercepting) and generates scorching It is illustrated in case where disease 10.
As described above, the flowing of mucus is intercepted, upper when the opening (1,2) of maxillary sinus MS or sinus frontalis FS is reduced Jaw sinus MS or sinus frontalis FS generates inflammation 10.
It is of the invention for treating nasosinusitis and expansion when being inserted into the opening (1,2) of maxillary sinus MS or sinus frontalis FS referring to Fig. 6 When opening the device of nasal sinus opening, in the case where being free from side effects to human body, in 100 quilt of main body that nasal sinus is open biodegradable It expands and expands opening (1,2), so as to put into paranasal sinusitis therapeutic agent into maxillary sinus MS or sinus frontalis FS.
Fig. 7 shows the device for treating nasosinusitis and expansion nasal sinus is open of still another embodiment of the invention, and Fig. 8 is The device for being used to treat nasosinusitis and expanding nasal sinus opening of Fig. 7 is applied to the sectional view of nasal sinus opening, Fig. 9 shows the present invention Still another embodiment for treat nasosinusitis and expand nasal sinus opening device, Figure 10 and 11 is to show for Fig. 9 to be used for It treats nasosinusitis and the device for expanding nasal sinus opening is applied to the sectional view of nasal sinus opening.
Firstly, the device for treating nasosinusitis and expansion nasal sinus opening of the invention is in insertion tube referring to Fig. 7 and Fig. 8 300 inside includes main body 100, and main body is discharged from the insertion tube 300 for the opening (1,2) for being inserted into maxillary sinus MS or sinus frontalis FS 100, so that main body 100 is positioned at the opening (1,2) of maxillary sinus MS or sinus frontalis FS.Certainly, as above-mentioned, although it is not shown, in main body 100 outer peripheral surface can be formed with the film for inhibiting the expansion of main body 100.
In addition, referring to Fig. 9 to Figure 11, it is of the invention for treat nasosinusitis and expand nasal sinus opening device further include by Distal portions (distal portion) 410, proximal part (proximal portion) 430 and 420 structure of distensible sacculus At foley's tube 400, main body 100 be formed as surround sacculus 420 outer peripheral surface.
Here, the expansion method of sacculus 420 is well known technology, therefore omit detailed description.
In addition, as the sacculus 420 for the opening (1,2) for being configured at maxillary sinus MS or sinus frontalis FS is inserted by lead W It is expanded into the foley's tube 400 of maxillary sinus MS or sinus frontalis FS, so that main body 100 is inflated, thus main body 100 is positioned at The opening (1,2) of jaw sinus MS or sinus frontalis FS.Certainly, as above-mentioned, although it is not shown, the outer peripheral surface in main body 100 can be formed with suppression The film of the expansion of main body 100 processed.
In addition, foley's tube 400 can remove sacculus 420 and execute suction function by distal portions 410, therefore can inhale Draw maxillary sinus MS or inflammation and impurity in sinus frontalis FS and is discharged to the outside.
Above explanation is only the one of the device for carrying out the present invention for treating nasosinusitis and expanding nasal sinus opening A embodiment, the present invention is not limited to one embodiment not to depart from of the invention want as recorded in claims below In the case where purport, various changes are can be performed in those skilled in the art, and it is included in technical idea of the invention.

Claims (1)

1. a kind of device for treating nasosinusitis and expanding nasal sinus opening, the device include:
Main body is made of the Biodegradable material being decomposed after the 1st set time in human body;And
The therapeutic agent of paranasal sinusitis is coated on at least one side of the main body,
The main body coated with the therapeutic agent is inflated after being inserted into reduced nasal sinus opening,
The main body has columnar eyed structure,
The device further includes film, the film surround contraction state the main body, by human body in the 2nd set time The Biodegradable material being decomposed later is constituted,
2nd time is shorter than the 1st time,
The film is corresponding with the entire length of the main body,
The device further includes foley's tube, and the main body which is coated with the therapeutic agent is inserted into the quilt The nasal sinus of diminution is open,
The main body is configured to surround the sacculus of the foley's tube, and the main body is swollen by the expansion of the sacculus It is swollen,
The main body is made of the suture of elasticity,
The device further includes insertion tube, and the main body which is coated with the therapeutic agent is inserted into described reduced Nasal sinus opening,
The main body is inflated when being discharged from the insertion tube,
The foley's tube is inserted into maxillary sinus or sinus frontalis, and the sacculus for being configured at the opening of maxillary sinus or sinus frontalis is expanded , the foley's tube can remove the sacculus and execute suction function by distal portions, therefore can attract maxillary sinus or Inflammation and impurity in sinus frontalis and be discharged to the outside.
CN201710545351.4A 2016-07-07 2017-07-06 For treating the device of nasosinusitis and expansion nasal sinus opening Active CN107582221B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2016-0086141 2016-07-07
KR1020160086141A KR101697533B1 (en) 2016-07-07 2016-07-07 Devices for dilating a paranasal sinus opening and for treating sinusitis

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CN107582221B true CN107582221B (en) 2019-06-18

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CN109758278B (en) * 2019-01-27 2020-12-04 乐畅医疗器械(上海)有限公司 Self-expansion nasal sinus support and taking and placing device thereof
KR20210114739A (en) 2020-03-11 2021-09-24 주식회사 에보레이 Apparatus for treating otorhinolaryngological disease
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