CN107570236A - The micro flow control chip device of the substrate containing PDMS based on dual drive CGCM - Google Patents
The micro flow control chip device of the substrate containing PDMS based on dual drive CGCM Download PDFInfo
- Publication number
- CN107570236A CN107570236A CN201610566971.1A CN201610566971A CN107570236A CN 107570236 A CN107570236 A CN 107570236A CN 201610566971 A CN201610566971 A CN 201610566971A CN 107570236 A CN107570236 A CN 107570236A
- Authority
- CN
- China
- Prior art keywords
- micro
- substrate
- micropump
- fluidic chip
- pipeline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The present invention relates to a kind of micro flow control chip device of the substrate containing PDMS based on dual drive CGCM, belong to analysis testing field.The substrate of micro-fluidic chip, physical presence series problem are made with dimethyl silicone polymer i.e. PDMS that is cheap and easily processing.This case main points are, the selected PDMS with ecosystem surface of substrate, and the chain ring type magnetic holding device for being equiped with miniature ultrasonic transducer units socket is positioned at the sample liquid stream terminal of the micro-fluidic chip its neighbor positions, with driving force of the ultrasonic wave induced synthesis based on interfacial tension difference, its driving force couples running with Micropump simultaneously, collaboration drives test liquid to flow to terminal direction flowing, micron silica granule filler is filled up in its pipeline of the chip, its function of the filler includes supporting pipeline inwall, and, with the set of hydrophily fluid channel come the hydrophobic pipeline of compensatory script, and, extruding, cover inner-walls of duct face and thereby reduce the chance that large biological molecule contacts with the internal face.
Description
Technical field
The present invention relates to a kind of micro flow control chip device of the substrate containing PDMS based on dual drive CGCM, belong to analysis
Testing field.
Background technology
For the microflow control technique overall general picture of itself, famous micro-fluidic expert Mr. Lin Ping Cheng may refer to not
The monograph " diagram Microfluid based Lab on a chip " gone out before long, the monograph is published via Science Press, and the monograph is for miniflow
Past of control technology, now, and, vision of the future etc. etc., suffer from detail, be deep into long opinion of detail
State.
The field that micro-fluidic chip is often applied to include to containing large biological molecule sample solution carry out it is various analysis,
Detection.
The basic framework of micro-fluidic chip, including it is etched with the substrate of conduit and the cover plate to fit together therewith, institute
State the fluid course on substrate, before upper cover plate is assembled, it is apparent on see to be exactly some conduits, wait until lid is covered thereon
After piece, just really closure forms the fluid course, and the conduit inner surface of the conduit is together with the part that surround the conduit
Cover plate forms described fluid course together;So, it is clear that assemble the fluid course after completing, its inner surface face
Long-pending major part is the inner surface area of that conduit, and in other words, the state or property of the conduit inner surface are substantially determined
The integrality or property of the fluid course are determined;Therefore say, the inner surface state or interior of this conduit of the structure on substrate
Surface nature is key factor;In principle, any material that can be kept or keep its solid forms substantially, can be used
To make substrate and cover plate, such as, the material that can act as substrate and cover plate can be monocrystalline silicon piece, quartz plate, sheet glass, height
Polymers such as dimethyl silicone polymer, polymethyl methacrylate, makrolon etc.;Certainly, the selection of substrate and the choosing of cover plate
Material be able to can also be differed with identical;From the point of view of material consumption, manufacture difficulty and application popularization prospect etc. etc., these
Not small difference, the especially selection of that substrate between material be present, have a great influence.
In various substrate making materials, dimethyl silicone polymer, i.e. PDMS, comparatively very easily shaping, at this
It is extremely simple that conduit is made on the substrate of sample, and the lower cost for material, substrate is made with the polydimethyl siloxane material,
Conduit is being suppressed or etched thereon, and is being engaged with the cover plate that the cheap material such as glass or polypropylene or other plastic sheets makes,
It is a kind of more satisfactory selection seemingly;Certainly, patch material can also select to use cheap polydimethyl siloxane material:
So, this substrate selection is the scheme of polydimethyl siloxane material, and material is extremely cheap, and making is extremely simple, seems and should also be as
It is extremely easy to popularize, promotes.
But thing is really not so simple.
First, this polydimethyl siloxane material, that is, the material that alphabetical PDMS is referred to of abridging, itself are a kind of strong
Strong hydrophobic material, conduit is built on this material, if without being operated for the modified of the conduit surface, then, it is whole
After body assembling is completed, that is, after covering cover plate, because the conduit its inner surface in structure occupies most fluid course
Inner surface, then, its strong hydrophobic property of the PDMS conduits inner surface, is deciding factor, it can be similar to water
The fine liquid stream of polar liquid of solution by becoming very difficult, its flow resistance is big, or even in general Micropump is all difficult to
Promote, certainly, if cover plate also selects to use the PDMS material, then, problem is substantially identical, similar;Therefore, existing
Among having technology, modification is modified particular for the conduit inner surface on the PDMS material, is necessary operation;So, this
The individual modified operation for PDMS conduit inner surfaces is pretty troublesomeThat falls nor this problem, forms serious technical puzzlement,
It is another problem:PDMS polymer molecules inside its body phase of this PDMS material substrate have to be diffused to the surface, moves automatically
The characteristic of shifting, the characteristic that this substrate body phase inside PDMS polymer molecules are diffused to the surface, migrated automatically, will cause by table
State after the modification of its inner surface of that conduit of face modifying and decorating can not maintain the sufficiently long time, and that is through surface
Holding time for conduit its inner surface state after modification is substantially only sufficient to the time needs for completing laboratory internal test experiments;
In other words, by surface is modified or the PDMS conduit inner surfaces of surface modification, after it is modified or institute's shape after modification is said
Into surface state can not be lasting, but soon automatically tend to or say become again surface be modified before surface state, compared with
The strong hydrophobic surface state of that script is returned in the short time, then, just think, such micro-fluidic chip can be big
Amount making, mass storage, it is widely popularized, answer is it is obvious that is, impossible.Conduit on this PDMS material, does not do
If surface modification, it can not pump and pass through similar to the fine liquid stream of polar solvent of the aqueous solution, chip also cannot just use;And such as
Fruit has been cooked surface modification, can not persistently keep its state after modifying again, or equally can not popularization and application.
According to the literature, there is a kind of expedient solution, be that a small amount of surface-active is added in sample to be tested solution
Agent, so as to which during test, dynamic, temporary transient effective surface hydrophilic layer is built temporarily in the PDMS conduits inner surface;
However, due to the amphipathic characteristic of surfactant, the introduced surfactant of the program is inevitable simultaneously also can be with sample solution
In tested composition occur combination so that tested composition can not be detected normally or it is detected ratio and dubiously dropped
It is low;The surfactant is possibly even fully wrapped around by tested composition with micelle form so that tested composition can not be detected or
Identification;Therefore, this kind adds the scheme of surfactant into sample solution, is far from a preferable solution.
So, how to accomplish that substrate can either be made using cheap PDMS material, and the conduit can be released
Inner surface decorating state can not persistently, chip can not largely make, largely lay in and then be widely popularized and such a make this area
The puzzlement that numerous professionals are entangled with for a long time, the highly difficult problem that exactly one its obvious technology barrier can not despise.
Be present many year in the highly difficult problem, so far, not yet properly settled.
Second, the PDMS material of non-surface modification, it is stated that, its surface is strongly hydrophobic above, this strong hydrophobic
Material surface and also have another problem, that is, this strong hydrophobic PDMS surfaces can adsorb large biological molecule, and
And these adsorbed large biological molecules can also further depression further on PDMS surfaces, gradually fall into it is gradually deep, until
It is heavy to be trapped within the body phase of PDMS substrates, in fact, this process, partly it is also due to PDMS material body phase interior polymer
Molecule, which has, to be diffused to the surface, caused by travel motion;Such case, it can also be explained from another angle, i.e. continue not
Disconnectedly from inside PDMS body phases to those polymer molecules of its diffusion into the surface, migration, its result moved, be little by little by that
It has been involved in a bit by the large biological molecule of adsorption within the body phase of PDMS substrates, briefly, these adsorbed biologies
Macromolecular is exactly to be swallowed up by PDMS substrate body phases;So, this PDMS substrates body phase swallows up the phenomenon of large biological molecule, its institute
Caused by influence, necessarily cause the severe deviations of all kinds of test data of experiment for being related to large biological molecule.
As described above, the problem of PDMS substrates, is, its not only adsorption large biological molecule, and swallow up biological big point
Son, so, as the large biological molecule of experiment test object, its disappearance will not stop because surface saturation is adsorbed, and
It is, it is constantly adsorbed, also constantly swallowed up.
On PDMS substrates, its body phase is constantly swallowed up and tests showing for associated biomolecule macromolecular in related experiment test process
As, it is to say that another kind, which is explained, substantial amounts of Minute pores in PDMS body phases be present, associated biomolecule macromolecular by after adsorption,
Depression enters these Minute pores, and then is swallowed up;However, inventor thinks, those can allow the sky of miniature scale
Qi leel squeezes into the Minute pores therebetween, not equal to saying that they also can directly allow the large biological molecule of relative large scale to enter
Enter, both difference on yardstick are huge, must not make sweeping generalizations.Explanation is bypassed, in any case, as dependence test analysis object
Large biological molecule is adsorbed by PDMS substrate conduits inner surface, and then is constantly swallowed up by PDMS substrate body phases, and this is known objective
Existing phenomenon.
, can be from containment PDMS surfaces pair in order to prevent swallow up effect of this PDMS substrate bodies relative to large biological molecule
The absorption of large biological molecule addresses, and method is chemically modified modification aiming at the PDMS material surface, for
For PDMS is the situation of substrate material, modification exactly is chemically modified to the surface of described channel portion, by chemistry
The conduit inner surface of modification, can contain its absorption to large biological molecule, and then avoid large biological molecule quilt
PDMS substrate body phases are swallowed up;But or that old problem, that is, the chemical modification on PDMS material surface is modified it
Surface state afterwards can not persistently be kept, the polymer molecule inside the PDMS substrate body phases its diffuse to the surface, migrate automatically
Process, can soon by that by surface chemical modification be modified conduit inner surface state become again script it is strong it is hydrophobic simultaneously
And the state of strong adsorption large biological molecule, in other words, no matter how professionals in the field turn from side to side, the PDMS substrates its
Conduit inner surface is always rapidly to strong hydrophobic surface state evolution.
So, how can either obtain that PDMS material price is extremely cheap, substrate makes extremely easy benefit, and can is enough
Reach and contain the absorption process of the PDMS substrate conduit inner surfaces to large biological molecule for a long time, and then prevent PDMS substrate bodies relative
The effect of swallowing up of large biological molecule so that related chip manufactured goods are able to maintain that a prolonged enough, rational shelf-life,
It is exactly a very intractable problem.The problem equally makes this area numerous specially as another problem addressed above
Industry personnel are entangled with, perplexed for a long time, and the problem is equally the highly difficult problem that its obvious technology barrier can not despise.Should
Also be present many year in problem, so far, also not yet properly settled.
Third, as described above, the PDMS conduit inner surfaces are strongly hydrophobic, and targetedly surface chemical modification or come to the surface
Learn modification to be difficult to again persistently, therefore, actually can only still belong to effective in the surface state after the modification of its surface or surface modification
It is used within short-term;If having had been subjected to that ofer short duration period of validity, and still by force if use, due to surface
State already again close to hydrophobic state, then certainly exists bigger flowing using usual Micropump driving sample liquid stream and hindered
Power, so, just by increasing Micropump pump power and pumping pressure test liquid can only be forced to flow to target direction flowing, as above institute
State, this PDMS material is soft, and sample liquid stream is pumped with too high, mechanical pumping pressure, will cause the substrate its
Bubbling, expanded, distortion, deformation, also, this high-pressure situations occur for the conduit that sample introduction end includes sample introduction end near zone
Under, the stripping between substrate and cover plate, this feelings also easily occur in the sample introduction end and its conduit of near zone and its periphery
Under shape, sample solution flows in the crack for entering appearance of the stripping afterwards between the substrate and cover plate of formation everywhere, this
Actually result in the damage of the micro-fluidic chip;Certainly, it is not in place if surface modification or surface modification script, also result in
There is said circumstances within the of short duration usual term of validity;In the case where carrying out liquid stream driving using additional Micropump merely,
The above-mentioned problem exists all the time.As described above, if it is preposition not do any surface modification or surface modification etc. completely
Operation, then, the above-mentioned problem will be even more serious, even without conduit bubbling described in sample introduction end and its near zone, swollen occurs
The problems such as changing, being peeled off between distortion, deformation and substrate and cover plate, merely because the flow resistance is excessive, using high pressure Micropump
Also sample liquid stream may not can be driven to be marched forward towards terminal side.
Fourth, the polydimethyl siloxane material, namely PDMS material, the active force very little wherein between polymer molecule,
The polymer molecule of low polymerization degree inside its body phase is in constantly into the dynamic process of surface migration, therefore, includes PDMS
After it has been formed, the surface topography in its inner-walls of duct face of chip can be because of described low polymerization degree polymer point for the chip of substrate material
Son moves about, pours into the surface and change, and the change of its pattern is somewhat similarly to Rheological Deformation, trickling deformation or creep and become
Pattern caused by shape institute is possible changes;In the higher PDMS material of some low polymerization degree component ratios, this kind somewhat similar
Can be showed in the phenomenon of Rheological Deformation, trickling deformation or the deformation of creep must be than more significant;This kind include PDMS substrates chip its
The dynamic of inner-walls of duct surface topography after shaping changes property, namely the described property or stream that are somewhat similarly to Rheological Deformation
Dropping down the property of deformation or the property of the deformation of creep, the word of rheology one is applied mechanically in this case, integration, also referred to as the rheological equationm of state or rheology become
Shape property, the dynamic of corresponding inner-walls of duct face pattern change, and this case is also referred to as rheology;As described above, because of this kind of material
Expect certain Rheological Deformation property as described above that its own has, its manufactured goods actually can at leisure Rheological Deformation and cause
The manufactured goods total form generation changes;Influence caused by its Rheological Deformation property, it is to be not easy to feel in terms of macroscopic perspective
Examine, still, for the very fine micro-fluidic chip of its internal structure, the rheological equationm of state can but cause bigger shadow
Ring, the fluid course namely the pipeline therefore, during pre-production formed, because the wall of its tube chamber of pipeline is main
It is the wall of PDMS materials, so, the cross-sectional area of the pipeline actually can gradually become because of rheology over time
It is small, stated differently, since the reason for the rheology, the natively finer pipeline that is flowed through for liquid sample
Its tube chamber the more can become the more narrow, in the case of flow time is sufficiently long, or even the pipeline tube chamber can partly close or all
Ground closes, and then make it that sample fluid course is thoroughly blocked, and closes with being even also not reaching to its luminal part of pipeline
The degree closed or fully closed, its fluid passage that can be provided of that pipeline narrow because of rheology, then, in pipeline
Its inner surface originally be exactly strongly it is hydrophobic in the case of, aqueous sample liquid is just more difficult to by becoming more so because of rheology
Narrow micro-channel, then, the influence of substrate rheology how is resisted, maintains the basic framework of the pipeline not occur seriously to become for a long time
The problem of shape, also, keep the long-term unobstructed of the pipeline is exactly a urgent need to resolve.
The content of the invention
The technical problem to be solved by the invention is to provide a package solution, while solve to address above
A series of problem.
The present invention solves the technical problem by following scheme, and the device that the program provides is that one kind is based on dual drive coupling
The micro flow control chip device of the substrate containing PDMS of syntype, the structure of the device include micro-fluidic chip, the micro-fluidic chip
Structure includes being bonded to each other the substrate and cover plate of installing together, and its test liquid of the micro-fluidic chip flows into sample end and the test liquid
The terminal of stream flowing is located remotely from each other, and between 3 centimetres and 10 centimetres, emphasis is for the distance between the sample introduction end and the terminal,
Its material of the substrate is dimethyl silicone polymer material, and its surface of the substrate is the surface of primary form, the table of the primary form
Face its be intended to refer to the not no primary form of the material by any surface chemical modification or any surface chemical modification
Surface, the structure of the device also include chain ring type magnetic holding device, and six links, institute are shared in its structure of the chain ring type magnetic holding device
Link is stated in strip, shaft-like or bar-shaped, each adjacent link is hinged to form chain link, and its appearance profile of the chain link is hexagonal
Cyclic structure, its locations of structures of each drift angle of the hexagonal annular structure is articulated structure position, the hexagonal annular knot
Two therein of structure is magnetic conductivity material in the link of opposite side position its material, four rings of remainder of the hexagonal annular structure
It is non-magnetic material to save its material, and the non magnetic material refers to the material not responded strongly to externally-applied magnetic field, and this is led
Magnet exciting coil is wound with a link among two links of magnetic material, the link for being wound with magnet exciting coil is encouraged at it
The pole shoe of a magnetic conductivity material is respectively equiped with the both sides neighbor positions of magnetic coil, shares two pole shoes, two poles
Boots are directed to the link of another magnetic conductivity material, and fixation is attached on its surface of the link of another magnetic conductivity material and is equiped with
Miniature ultrasonic transducer units, the chain ring type magnetic holding device socket of electromagnetism adhesive strength is relied on to be positioned at its institute of the micro-fluidic chip
State the close position of terminal, and, higher-order of oscillation electric signal transmission cable, one end of the higher-order of oscillation electric signal transmission cable with
The miniature ultrasonic transducer units link together;The chain ring type magnetic holding device provides a function of facilitating the device to disassemble;
Its major function of the miniature ultrasonic transducer units is in the actual sample introduction test of micro-fluidic chip, utilizes the sample introduction end and institute
State on the distance between terminal and the miniature ultrasonic transducer units installation position difference and its ultrasonic intensity experienced
Difference, the difference between its interfacial tension of sample introduction end described in induced synthesis and the terminal its interfacial tension, the micro-fluidic core
Interfacial tension difference between the piece both ends can form pressure gap between the both ends of the micro-fluidic chip, the pressure gap
Sample solution can be driven to the end flow;It is soft and have the substrate of the dimethyl silicone polymer material of elasticity its function bag
Include with its property to the strong absorption of ultrasonic wave, ultrasonic wave is absorbed strongly, and thereby in the micro-fluidic chip terminal
The rapid decrement of ultrasonic intensity is realized within to the limited short distance between the sample introduction end;And Micropump, the Micropump is with being somebody's turn to do
Sample introduction end connects, and the Micropump is built-in Micropump or external Micropump;The function of the Micropump is pumped with the mechanicalness of the Micropump
Interfacial tension difference its caused driving force between the both ends that strength induces come the ultrasonic wave is supported mutually, mutually
Mutually adjust, be mutually coupled, the power that one driving test liquid flows to the terminal direction flowing is pooled in a manner of Collaboration
Amount;Described its thickness of cover plate and substrate is between 1.0 millimeters and 5.0 millimeters;And many silica dioxide granules, should
Many silica dioxide granules are filled in the pipeline of the micro-fluidic chip, and its tube chamber of the pipeline is by many silica
Particle is filled up, and for its particle size range of the silica dioxide granule between 10 microns and 200 microns, the silica dioxide granule is two
Its shared percentage by weight of silica crystalline particles, silica glass granule or silica composition is inorganic more than 80%
Glass particle.
Its particle diameter of the silica dioxide granule can be that the basis between 10 microns and 200 microns is actually needed and any
The particle diameter specified, such as 10 microns, 30 microns, 70 microns, 100 microns, 150 microns or 200 microns of the particle diameter, etc..
The scope of further preferred its particle diameter of the silica dioxide granule is between 100 microns and 200 microns.
Its pattern of the silica dioxide granule is unlimited, and the silica dioxide granule for example can be spheric granules, rod-shaped particles, length
Cube shape particle or any amorphous granular.
The various silica dioxide granules manufacturing technology of itself is known technology.
Various forms, the silica dioxide granule market of all size are on sale.
The silica dioxide granule can also customize to specialized factory.
The preferred scope of its internal diameter of pipeline is between 500 microns and 1000 microns;It is but excellent compared to above-mentioned
The internal diameter of the pipeline scope of choosing, more tiny internal diameter of the pipeline or thicker internal diameter of the pipeline are also what this case was allowed.
The word of Micropump one art-recognized meanings of itself are known for the professional in micro-fluidic chip field.
The Micropump both can be the Micropump of external form;The Micropump can also do into or say the embedded micro-fluidic chip
The Micropump of the built in version of its internal sample introduction end structure position or the sample introduction end Near-neighbor Structure position.
For example miniature piezoelectric pump of the Micropump, miniature peristaltic pump or miniature air driven pump.
The word of magnet exciting coil one art-recognized meanings of itself are known.
The word of magnetic conductivity material one art-recognized meanings of itself are known;The material for belonging to magnetic conductivity material is for example pure
Iron, silicon steel, soft magnetic ferrite etc..
Non magnetic material described in this case refers to the material not responded strongly to externally-applied magnetic field, belongs to the non magnetic material
The material of matter such as metallic copper, metallic zinc, ormolu, metallic aluminium, almag etc..
The be hinged word art-recognized meanings of itself field in Machine Design is known.
Only for professional of the word of ultrasonic transducer one art-recognized meanings of itself for ultrasonic technology field,
It is known.
Various sizes, variously-shaped ultrasonic transducer are commercially available;Its size of commercially available miniature ultrasonic transducer units
It may diminish to the magnitude only calculated with millimeter.
Only with regard to miniature ultrasonic transducer units its technique for fixing on general industry application solid body surface its
It is known general technology for the professional in ultrasonic technology field for body.This case is not to this expansion superfluous words.
Only with regard to naked PDMS substrates itself conduit molding or lithographic technique for, be open-and-shut known technology.
The industrial products market of involved its all size of higher-order of oscillation electric signal transmission cable is on sale.
The structure of the device can also include higher-order of oscillation electric signal generator;The higher-order of oscillation electric signal transmission cable
Its other end can be connected with the higher-order of oscillation electric signal generator.
The involved higher-order of oscillation electric signal generator technology of itself, come for the professional in ultrasonic technology field
Say, be simple and known;The higher-order of oscillation electric signal generator can customize to ultrasonic instrument specialized factory.
The preferred scope of its specified ultrasonic wave transmission power of the miniature ultrasonic transducer units is between 2 milliwatts and 9000 milliwatts
Between;The preferred scope of the frequency of its ultrasonic wave operationally launched of the miniature ultrasonic transducer units be between 100KHz with
Between 12MHz.
This case device can further include some annexes certainly, and the annex can for example coordinate with micro-fluidic chip
The electrically or optically detection device used.The equipment that the electricity, optics etc. are used cooperatively with micro-fluidic chip, may refer to
The monograph.
The cover plate in chip structure, its material can allow to be any electrical insulating property material, such as:Polypropylene,
Glass, polymethyl methacrylate, dimethyl silicone polymer, etc., in order to make smaller size of micro-fluidic chip, for example do
Into the micro-fluidic chip of only 2.0 centimetres to 3.0 centimetres of super-small of length, and realized in the extremely short distance to ultrasonic wave
Extremely fast decay, can preferably dimethyl silicone polymer be used as cover plate.Certainly, selected on large-sized micro-fluidic chip
Using dimethyl silicone polymer it is used as the cover plate, and this case technical scheme is allowed.
Described its thickness of cover plate and substrate can allow be any setting the thickness for being easy to assembling, the thickness of recommendation or say
Preferable thickness is between 1.0 millimeters and 5.0 millimeters.Less thickness is advantageous to save material.
It is an advantage of the invention that its close position relies on electromagnetism adhesive strength set in the terminal of the micro-fluidic chip
Connect the described chain ring type magnetic holding device of positioning, and it is miniature in the chain ring type magnetic holding device one magnetic conductivity link to attach installation
Ultrasonic transducer, with the ultrasonic wave of miniature ultrasonic transducer units transmitting low-power, high-frequency band, meanwhile, utilize poly- diformazan
Its strong absorbability to ultrasonic wave of radical siloxane substrate, in shorter distance, it is, from the terminal to described
In the very short distance of only several centimeters yardsticks between sample introduction end, reach the rapid decrement of ultrasonic intensity, thereby in the miniflow
The difference of the interfacial tension is caused at the both ends of control chip, the pressure gap that this kind is formed by Ultrasonic Radiation itself
It is exactly that one drives the strength of sample solution to the end flow, while the driving force phase mutual coupling that it is gone back and Micropump is provided
Close, Collaboration, above-mentioned two bursts of strength makes a concerted effort to drive sample liquid stream to flow to the terminal direction in the pipeline in the lump.
Its scheme of this case and by the pipeline except electrode installation take up space in addition to all clearance spaces whole
Filled up with the silica dioxide granule.Those are filled in the silica dioxide granule in pipeline, and this case is to its overall abbreviation titanium dioxide
Silicon grain filler, its function include support, withstand the tube chamber of the pipeline its inwall so that the tube chamber of the pipeline is from because of institute
State rheology and narrow, prevent its reduced cross-sectional area of the tube chamber of the pipeline or even close, so as to maintain the base of the pipeline for a long time
Serious deformation does not occur for this framework.
Numerous silica dioxide granule entities are mutually banked up under this case framework together at random in the pipeline, the titanium dioxide
The function of silicon grain filler, also include certainly with the hydrophilic surface of its silica dioxide granule, utilize each adjacent titanium dioxide
Mutual formed complications are continuous and its inner surface that is mutually close together by water-wetted surface of silicon grain has hydrophilic
The space of property, in the hydrophilic fluid channel of the pipeline Inner Constitution network morphology, although this complications can be continuous
All the time the fluid channel with hydrophilic nmature, then, inside the tube chamber of the pipeline simultaneously and a plurality of miniflow deposited
The effect of its synthesis of road, integrated, cumulative superposition in other words, is the equal of the relatively fine hydrophilic capillary of caliber
Passage;Its presence of the continuous hydrophilic fluid channel of the complications, the PDMS of the primary form is counteracted to a large extent
The flow resistance for liquid sample caused by the strong hydrophobic property in its surface of substrate;In other words, because of liquid sample, it is accounted for
The composition of maximum ratio is water, and liquid sample is substantially exactly the aqueous solution, therefore, the presence of the silica dioxide granule filler,
Can significantly overcome with the unmodified PDMS substrates of hydrophobic property and surface its to the aqueous solution it is incompatible, repel and
Barrier effect, so be greatly reduced belong to properties of Aqueous Solution sample liquid stream its be advanced through the resistance of pipeline.
Under this case framework, inside the tube chamber of the pipeline, the area of its lumen wall wall of former pipeline, because of described two
The rigid of silicon oxide particle filler ties up, the table of part hydrophobic property that still can also be exposed on lumen wall wall
Its area of face is already dramatically reduced, and the area on its still exposed part surface for belonging to hydrophobic property is much
Less than the wall surface area of the hydrophobic property of the lumen wall wall in the presence of no silica dioxide granule filler;
So, under this case framework, in its lumen of the pipeline, its remaining hydrophobic surface increases surface newly with hydrophilic part, and it is folded
Adding, comprehensive, summation, cumulative technique effect, is to form the surface for tending to be hydrophilic on the whole;In other words, in institute
State inside the tube chamber of pipeline, its interfacial tension between sample solution of the part surface of remaining hydrophobic property, plus parent
The part of aqueous nature increases its interfacial tension between sample solution of surface newly, that it is superimposed, comprehensive, summation, cumulative
Technique effect, be so that its solid-liquid interfacial tension inside the tube chamber of the pipeline synergy level off to capillary glass tube its
Interfacial tension between tube chamber inner surface and sample solution.
On the other hand, due to its rheological equationms of state of the PDMS as substrate material, it is filled in the pipeline
The interior silica dioxide granule filler, can gradually by constantly Rheological Deformation and to arest neighbors free space promote PDMS
The pipeline wall of material more tightly wraps up, and this process eventually causes those part two for pressing close to the lumen wall wall
Silicon oxide particle is stuck in original place or is stuck in original place or embedding in-situ silica dioxide granule and its embedded in original place, the part
Incarceration is together, described due to this reason each other for the remaining silica dioxide granule banked up with being mutually closely packed together
Silica dioxide granule filler just will not move in the pipeline easily, silica dioxide granule therein be also substantially all by
Original place is locked in, therefore the stream framework of the micro-fluidic chip can be kept for a long time.
The particle size range of its particle of this case silica dioxide granule filler between 10 microns and 200 microns, compared to
For general organic molecule, general large biological molecule, the particle diameter of its particle of this case silica dioxide granule filler can be rated as huge
Greatly, due to its huge particle diameter, and the inner surface of the surface of its polarity and the pipeline of strong hydrophobic PDMS materials can not
Mutually perhaps say and mutually melt, then, the huge silica dioxide granule of this kind of particle diameter can not be by the pipeline of PDMS materials
Surface is adsorbed, and can not more be swallowed up by the inner surface of the pipeline of PDMS materials, the huge titanium dioxide of this kind of particle diameter
Silicon grain surely not be fully sunk in easily or sink to completely PDMS materials its among intrinsic many Minute pores, and
Because above it is stated that the rheology the reason for, the silica dioxide granule filler can be stuck in original place in other words it is embedding
In original place without moving easily.
Inside the tube chamber of the pipeline, its lumen wall wall of former pipeline is entirely the surface of hydrophobic property originally, such as
Upper described, under this case framework, rigid because of the silica dioxide granule filler ties up, on lumen wall wall still also
Its area of the surface of part hydrophobic property that can be exposed is already dramatically reduced, and it is still exposed to belong to hydrophobicity
The area on the part surface of matter has been far smaller than the tube chamber in the presence of no silica dioxide granule filler
The wall surface area of the hydrophobic property of inwall wall;The reason for because of the rheology, it is close to those dioxies of lumen wall wall
Silicon carbide particle, little by little it is partially embedded into or is partly absorbed among the lumen wall wall, the dioxy among the state
Silicon carbide particle its towards the part surface of lumen wall wall with have occurred and that matching deformation the lumen wall wall it is tight
Closely connected conjunction, then, the matching is deformed and closely pasted with silica particles having occurred and that in lumen wall wall
The part wall of conjunction actually can not contact with flowing through the sample solution of pipeline, that is to say, that the wall of this part is
Through suction-operated can not be produced to the large biological molecule therein that flows through the sample solution of pipeline and organic molecule.Based on above-mentioned
Mechanism, then because fill up the pipeline the silica dioxide granule filler its presence, its lumen wall wall of the pipeline
The overwhelming majority in face is tightly covered, and these described walls tightly covered can not be with flowing through the pipeline
Sample solution contact, only remaining fraction be not brought into close contact by its surface of silica dioxide granule, tightly cover
Hydrophobic surface may be contacted with sample solution, in other words, under this case framework, large biological molecule in sample solution and have
Its direct touch opportunity with hydrophobic PDMS walls of machine molecule is significantly reduced, thus, the lumen wall faces of PDMS materials its
The adsorptive hindrance and interference of swallowing up of large biological molecule and organic molecule are greatly reduced;As described above, this case scheme
Be advantageous to exclude or weaken the adsorptive hindrance and swallow up interference, be advantageous to be lifted the reliability of correlation analysis test data.
As described above, this case silica dioxide granule filler, its function actually includes being similar to being directed to PDMS materials
Inner surface of pipeline carry out chemical modification effect, functioning as its this respect of this case is by the pipeline of the PDMS materials
Surface by the surface modification of hydrophobic property into the surface of hydrophilic nmature, still, with general, usual PDMS surface chemical modifications
Its hydrophilic chemical decorative layer retention time is short, hydrophilic effect can not keep situation prolonged enough different, particle described in this case
Huge silica dioxide granule filler, its particle being stuck by rheology can not both be moved easily, its huge particle diameter
Particle can not more be swallowed up easily by the inner-walls of duct of PDMS materials, and therefore, its from this respect is similar to surface chemical modification
Technique effect on see, its technique effect of this case, be form it is permanent, can not erase, can not consume, not be corroded, not by
Hydrophilic surface reforming layer swallowing up, being not dissolved, it is just comparable to one kind in its correlation table of PDMS base materials in effect
The permanent hydrophilic modifying superficial layer built on face.
With the simultaneous Micropump of miniature ultrasonic transducer units in its structure of micro-fluidic chip, its function is, with this
Its caused drive of the interfacial tension difference that the mechanicalness pumping strength of Micropump is come between the both ends of ultrasonic wave induction
Amount of power is supported mutually, adjusts mutually, is mutually coupled, and is pooled in a manner of Collaboration described in one driving test liquid flow direction
The strength of terminal direction flowing;The presence of the Micropump so that the miniature ultrasonic transducer units its ultrasonic wave emissive porwers can be by
Appropriateness is allowed to reduce, this is particularly suitable for for the situation containing ultrasonic wave sensitive composition in detection object;And because this is miniature super
The presence of acoustic wave transducer and its radiated ultrasonic wave, the micro-fluidic chip its both ends interfacial tension can be induced and difference occur
And the special driving force for being directed to sample solution is thereby brought, meanwhile, due also to being filled out in its pipeline of this case micro-fluidic chip
Fill the silica dioxide granule with hydrophilic nmature, then, in the scenario above, its resistance of flowing in the pipeline of sample liquid stream
Power is greatly reduced, and correspondingly, its running resistance of the Micropump is greatly reduced, and so, the Micropump just can be with than relatively low pumping pressure
Power carries out the pumping work for the sample solution, because mechanical pumping pressure is greatly reduced, therefore, such one
Under kind of situation, be just not susceptible to because the sample introduction end caused by sample introduction end Micropump its mechanicalness pumping pressure is excessive and its near
The problems such as stripping between the conduit bubbling in region, expansion, deformation, distortion and the region substrate and cover plate etc.;This case should
Dual drive couples the scheme of running and added for the handling of sample fluid flow action, can allow for using ultrasound
Intensity of wave, ultrasonic frequency, Micropump pump power, Micropump pumping pressure etc. multiple indexs are fast to be directed to the flowing of the flowing
Rate, flowing action include flow forward or pause flowing or acceleration flowing etc. flowing action carry out multi-parameter and accurately manipulated;Such as
It is upper described, the presence of the Micropump so that its ultrasonic wave emissive porwer of the miniature ultrasonic transducer units can be allowed to appropriate reduction,
So, the feature additionally aids described its sensitive coating of working electrode of protection, is allowed to from ultrasound injury.
It is related that the technical scheme of this case has dissolved its application to dimethyl silicone polymer substrate addressed above totally
A series of technical barriers.Based on this case scheme, this kind be very cheap and the easily dimethyl silicone polymer material of processing and fabricating
Material be just possible in the micro-fluidic chip its prepare, production, using etc. field play bigger effect.
Attached in the chain ring type magnetic holding device one magnetic conductivity link in this case structure it is fixed installed it is described miniature
Ultrasonic transducer, this architecture provides a function of facilitating the device to disassemble, in this way, the chain ring type magnetic holding device is together with it
The miniature ultrasonic transducer units attached in one magnetic conductivity link just easily can be mutually disengaged with the micro-fluidic chip,
So, the component that the part can freely depart from is reused many times in which just can circulate benignly;The architectural feature is advantageous to save
The about use cost of the device.
Brief description of the drawings
Fig. 1 be this case device chain ring type magnetic holding device its with appearance side rough under the micro-fluidic chip socket state
View, the legend and indicates the relative position relation under the socket state between each component.
Fig. 2 is the outside side view under another viewing angle of this case device;Fig. 2 viewing angle and Fig. 1's
Viewing angle is mutually perpendicular to;The components such as Micropump are depicted without in Fig. 2.
In figure, 1 is chain ring type magnetic holding device, and 2 be the terminal of the micro-fluidic chip, and 3 be the institute of the micro-fluidic chip
Sample introduction end is stated, 4 be the substrate of dimethyl silicone polymer material, and 5 be cover plate, and 6 be miniature ultrasonic transducer units, and 7 be the higher-order of oscillation
Electric signal transmission cable, 8,15 respectively be positioned at different structure position two magnetic conductivity materials link, two magnetic conductivity
The link of material end-to-end relation each other in the structure shown here, 9,22 be two pole shoes positioned at different structure position respectively, 10,12,
14th, 17,19,21 be six pin joints in six diverse locations respectively, and 11,13,18,20 be to be in four different positions respectively
The link for the four non magnetic materials put, 16 be magnet exciting coil, and 23 be infusion tube, and 24 be Micropump;The chain ring type in legend
Magnetic holding device structure is only the legend structure of signal, and the actual chain ring type magnetic holding device structure is not limited to the legend chain ring type electromagnetism
Clamp structure;Arrow in legend indicate the micro-fluidic chip its in actual motion, by pressure at two ends difference drive, its try
The flow direction of sample liquid stream.
Embodiment
In this case that Fig. 1 and Fig. 2 are shown embodiment, the structure of the device includes micro-fluidic chip, and this is micro-fluidic
The structure of chip includes being bonded to each other the substrate 4 and cover plate 5 of installing together, and its test liquid of the micro-fluidic chip flows into sample end 3
It is located remotely from each other with the terminal 2 of the sample fluid flow, the distance between the sample introduction end 3 and the terminal 2 are between 3 centimetres and 10 centimetres
Between, emphasis is, its material of the substrate 4 is dimethyl silicone polymer material, and its surface of substrate 4 is the surface of primary form,
The surface of the primary form its be intended to refer to not by the material of any surface chemical modification or any surface chemical modification
The surface of the primary form of matter, the structure of the device also include chain ring type magnetic holding device 1, its structure of the chain ring type magnetic holding device 1
In share six links 8,11,13,15,18,20, the link 8,11,13,15,18,20 is in strip, shaft-like or bar-shaped, respectively
Adjacent link is hinged to form chain link, the hexagonal cyclic structure of its appearance profile of the chain link, the hexagonal annular structure
Its locations of structures of each drift angle 10,12,14,17,19,21 is articulated structure position, the hexagonal annular structure therein two
Individual link 8,15 its material in opposite side position is magnetic conductivity material, the remaining four processes 11 of the hexagonal annular structure,
13rd, 18,20 its material are non-magnetic materials, and the non magnetic material refers to the material not responded strongly to externally-applied magnetic field
Matter, magnet exciting coil 16 is wound with a link 15 among two links of the magnetic conductivity material, this is wound with magnet exciting coil
16 link 15 is respectively equiped with the pole shoe of a magnetic conductivity material in the both sides neighbor positions of its magnet exciting coil 16, shares two
The pole shoe 9,22, two pole shoes 9,22 are directed to the link 8 of another magnetic conductivity material, another magnetic conductivity material
Fixed chain ring type electromagnetic clamp for being equiped with miniature ultrasonic transducer units 6, relying on electromagnetism adhesive strength is attached on its surface of link 8
The socket of tool 1 is positioned at the close position of its terminal 2 of the micro-fluidic chip, and, higher-order of oscillation electric signal transmission cable 7,
One end of the higher-order of oscillation electric signal transmission cable 7 links together with the miniature ultrasonic transducer units 6;The chain ring type electromagnetic clamp
Tool 1 provides a function of facilitating the device to disassemble;Its major function of the miniature ultrasonic transducer units 6 is in micro-fluidic chip
During actual sample introduction test, using between the sample introduction end 3 and the terminal 2 and the installation position of miniature ultrasonic transducer units 6
Distance difference and its ultrasonic intensity experienced on difference, its interfacial tension of sample introduction end 3 described in induced synthesis with
Difference between described its interfacial tension of terminal 2, the interfacial tension difference between the micro-fluidic chip both ends 2,3 can be micro- at this
Pressure gap is formed between the both ends 2,3 of fluidic chip, the pressure gap can drive sample solution to be flowed to the direction of terminal 2
It is dynamic;It is soft and have the substrate 4 of the dimethyl silicone polymer material of elasticity its function and include with it to the strong absorption of ultrasonic wave
Property, ultrasonic wave is absorbed strongly, and it is thereby limited between micro-fluidic chip terminal 2 to the sample introduction end 3
The rapid decrement of ultrasonic intensity is realized within short distance;And Micropump 24, the Micropump 24 are connected with the sample introduction end 3;The Micropump
24 function is the interface come with the mechanicalness pumping strength of the Micropump 24 between the both ends 2,3 of ultrasonic wave induction
Its caused driving force of tension difference is supported mutually, adjusts mutually, is mutually coupled, and one is pooled in a manner of Collaboration
Stock driving test liquid flows to the strength of the direction of terminal 2 flowing;The cover plate 5 and substrate 4 its thickness between 1.0 millimeters with
Between 5.0 millimeters;And many silica dioxide granules, many silica dioxide granules are filled in the micro-fluidic chip
In pipeline, its tube chamber of the pipeline is filled up by many silica dioxide granules, and its particle size range of the silica dioxide granule is situated between
Between 10 microns and 200 microns, the silica dioxide granule is silica crystalline particles, silica glass granule or dioxy
Its inorganic glass particles of shared percentage by weight more than 80% of SiClx composition.
Arrow in legend indicate the micro-fluidic chip its in actual motion, by both ends 2,3 pressure differentials drive, its
The flow direction of sample liquid stream.
The associate members such as the higher-order of oscillation electric signal generator are depicted without in Fig. 1 and Fig. 2.
Involved magnetic conductive material and involved nonmagnetic substance market are on sale.
Involved miniature ultrasonic transducer units 6 are commercially available;It can also be customized to ultrasonic transducer producer.
The Micropump 24 can customize to specialized factory.
Its connected mode with various micro-fluidic chip of various Micropump is known.
Involved higher-order of oscillation electric signal transmission cable 7 is commercially available;Can also be special to ultrasonic transducer producer or cable
Industry producer customizes.
Involved higher-order of oscillation electric signal generator market has the product close to needs commercially available;It can also be customized to relevant manufacturers
The word of Micropump one art-recognized meanings of itself are known for the professional in micro-fluidic chip field.
For example miniature piezoelectric pump of the Micropump, miniature peristaltic pump, miniature air driven pump, etc..
The Micropump both can be the Micropump of external form;The Micropump can also do into or say the embedded micro-fluidic chip
The Micropump of the built in version of internal its sample introduction end structure position or the sample introduction end Near-neighbor Structure position, its basic structure key element with it is outer
The Micropump for putting form is identical.Micropump in legend is the Micropump of external form.
Claims (5)
1. the micro flow control chip device of the substrate containing PDMS based on dual drive CGCM, the structure of the device includes micro-fluidic core
Piece, the structure of the micro-fluidic chip include being bonded to each other the substrate and cover plate of installing together, its test liquid of the micro-fluidic chip
Flow into sample end and the terminal of the sample fluid flow be located remotely from each other, the distance between the sample introduction end and the terminal between 3 centimetres with
Between 10 centimetres, it is characterised in that its material of the substrate is dimethyl silicone polymer material, and its surface of the substrate is primary form
Surface, the surface of the primary form its be intended to refer to and do not pass through any surface chemical modification or any surface chemical modification
The material primary form surface, the structure of the device also includes chain ring type magnetic holding device, the chain ring type magnetic holding device its
Share six links in structure, in strip, shaft-like or bar-shaped, each adjacent link is hinged to form chain link the link, should
The hexagonal cyclic structure of its appearance profile of chain link, its locations of structures of each drift angle of the hexagonal annular structure is be hinged knot
Structure position, in the link of opposite side position, its material is magnetic conductivity material to two therein of the hexagonal annular structure, six side
Its material of the remaining four processes of shape cyclic structure is non-magnetic material, and the non magnetic material refers to not having to externally-applied magnetic field
There is the material responded strongly, be wound with magnet exciting coil in a link among two links of the magnetic conductivity material, the winding
The link for having magnet exciting coil is respectively equiped with the pole shoe of a magnetic conductivity material in the both sides neighbor positions of its magnet exciting coil, shares
Two pole shoes, two pole shoes are directed to the link of another magnetic conductivity material, the link of another magnetic conductivity material
The fixed chain ring type magnetic holding device socket for being equiped with miniature ultrasonic transducer units, relying on electromagnetism adhesive strength is attached on its surface
The close position of its terminal of the micro-fluidic chip is positioned at, and, higher-order of oscillation electric signal transmission cable, the higher-order of oscillation
One end of electric signal transmission cable links together with the miniature ultrasonic transducer units;The chain ring type magnetic holding device provides one
The function of facilitating the device to disassemble;Its major function of the miniature ultrasonic transducer units is in the actual sample introduction test of micro-fluidic chip
When, using the sample introduction end and the distance between the terminal and the miniature ultrasonic transducer units installation position difference and its
The difference on ultrasonic intensity experienced, its interfacial tension of sample introduction end described in induced synthesis and its interfacial tension of the terminal
Between difference, interfacial tension difference between the micro-fluidic chip both ends can between the both ends of the micro-fluidic chip shape
Into pressure gap, the pressure gap can drive sample solution to the end flow;The poly dimethyl silicon that is soft and having elasticity
Its function of the substrate of oxygen alkane material includes, with its property to the strong absorption of ultrasonic wave, absorbing ultrasonic wave strongly, and by
This realizes the fast express delivery of ultrasonic intensity within micro-fluidic chip terminal to the limited short distance between the sample introduction end
Subtract;And Micropump, the Micropump are connected with the sample introduction end, the Micropump is built-in Micropump or external Micropump;The function of the Micropump
It is interfacial tension difference its band come with the mechanicalness of Micropump pumping strength between the both ends of ultrasonic wave induction
The driving force come is supported mutually, adjusts mutually, is mutually coupled, and one driving sample liquid stream is pooled in a manner of Collaboration
The strength flowed to the terminal direction;Described its thickness of cover plate and substrate is between 1.0 millimeters and 5.0 millimeters;And
Many silica dioxide granules, many silica dioxide granules are filled in the pipeline of the micro-fluidic chip, the pipeline its
Tube chamber is filled up by many silica dioxide granules, and its particle size range of the silica dioxide granule is between 10 microns and 200 microns
Between, the silica dioxide granule is silica crystalline particles, silica glass granule or silica composition its shared weight
Measure inorganic glass particles of the percentage more than 80%.
2. the micro flow control chip device of the substrate according to claim 1 containing PDMS based on dual drive CGCM, it is special
Sign is that its material of the cover plate is dimethyl silicone polymer material.
3. the micro flow control chip device of the substrate according to claim 1 containing PDMS based on dual drive CGCM, it is special
Sign is that between 100 microns and 200 microns, its inside diameter ranges of the pipeline are situated between its particle size range of the silica dioxide granule
Between 500 microns and 1000 microns.
4. the micro flow control chip device of the substrate according to claim 1 containing PDMS based on dual drive CGCM, it is special
Sign is, the structure of the device also includes higher-order of oscillation electric signal generator, and its is another for the higher-order of oscillation electric signal transmission cable
One end is connected with the higher-order of oscillation electric signal generator.
5. the micro flow control chip device of the substrate according to claim 1 containing PDMS based on dual drive CGCM, it is special
Sign is that for its specified ultrasonic wave transmission power of the miniature ultrasonic transducer units between 2 milliwatts and 9000 milliwatts, this is miniature super
The frequency of its ultrasonic wave operationally launched of acoustic wave transducer is between 100KHz and 12MHz.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610566971.1A CN107570236A (en) | 2016-07-05 | 2016-07-05 | The micro flow control chip device of the substrate containing PDMS based on dual drive CGCM |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610566971.1A CN107570236A (en) | 2016-07-05 | 2016-07-05 | The micro flow control chip device of the substrate containing PDMS based on dual drive CGCM |
Publications (1)
Publication Number | Publication Date |
---|---|
CN107570236A true CN107570236A (en) | 2018-01-12 |
Family
ID=61048954
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610566971.1A Pending CN107570236A (en) | 2016-07-05 | 2016-07-05 | The micro flow control chip device of the substrate containing PDMS based on dual drive CGCM |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN107570236A (en) |
-
2016
- 2016-07-05 CN CN201610566971.1A patent/CN107570236A/en active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN107570236A (en) | The micro flow control chip device of the substrate containing PDMS based on dual drive CGCM | |
CN107457012A (en) | For the micro flow control chip device of the double mode coupling driving of hydrophobic base sheet matter | |
CN107754954A (en) | Make the hypotype swine flu detection Multichannel device of substrate with cheap hydrophobic material | |
CN107597203A (en) | The micro flow control chip device of the substrate containing PDMS based on dual drive CGCM | |
CN107754887A (en) | Using the micro flow control chip device of PDMS material substrates | |
CN107570240A (en) | Multichannel and the cholera diagnosis micro flow control chip device of dual drive coupling running | |
CN107552113A (en) | A kind of substrate material is PDMS cholera diagnosis micro flow control chip device | |
CN107754958A (en) | Driving mechanism it is various and can Collaboration controller used in syphilis diagnosis micro flow control chip device | |
CN107754917A (en) | A kind of micro flow control chip device for taking new fluid type of drive | |
CN107570237A (en) | Driving mechanism it is various and can Collaboration controller used in syphilis diagnosis micro flow control chip device | |
CN107486257A (en) | The driving cholera diagnosis device easily-disassembled and recyclable with component | |
CN107486258A (en) | Couple the micro flow control chip device for including hydrophobic substrate of dual drive pattern | |
CN107570235A (en) | The hypotype swine flu multi-channel testing device of dual drive coupling containing hydrophobic substrate | |
CN107754922A (en) | Multichannel and the cholera diagnosis micro flow control chip device of dual drive coupling running | |
CN107570238A (en) | For the controller used in syphilis diagnosis Multichannel device of the dual drive coupling running of hydrophobic substrate | |
CN107764999A (en) | The cholera diagnosis micro flow control chip device of double-unit system driving coupling running | |
CN107754920A (en) | The hypotype swine flu multi-channel testing device of dual drive coupling containing hydrophobic substrate | |
CN107754923A (en) | For the controller used in syphilis diagnosis Multichannel device of the dual drive coupling running of hydrophobic substrate | |
CN107362840A (en) | Using the micro flow control chip device of PDMS material substrates | |
CN107570239A (en) | The cholera diagnosis micro flow control chip device of double-unit system driving coupling running | |
CN107576792A (en) | Make the hypotype swine flu detection Multichannel device of substrate with cheap hydrophobic material | |
CN107552104A (en) | The micro flow control chip device containing hydrophobic substrate of two kinds of type of drive coupling runnings | |
CN107570241A (en) | Four-way and the AIDS diagnosis micro fluidic device of dual drive coupling running | |
CN107754955A (en) | Four-way and the AIDS diagnosis micro fluidic device of dual drive coupling running | |
CN107754919A (en) | Controller used in syphilis diagnosis micro flow control chip device based on dual drive coupling operation principles |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180112 |
|
WD01 | Invention patent application deemed withdrawn after publication |