CN107569764A - One kind is based on the micro- electromagnetism anal intestine postoperative administration devices of PDMS - Google Patents
One kind is based on the micro- electromagnetism anal intestine postoperative administration devices of PDMS Download PDFInfo
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- CN107569764A CN107569764A CN201710734299.7A CN201710734299A CN107569764A CN 107569764 A CN107569764 A CN 107569764A CN 201710734299 A CN201710734299 A CN 201710734299A CN 107569764 A CN107569764 A CN 107569764A
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Abstract
The invention discloses one kind to be based on the micro- electromagnetism anal intestine postoperative administration devices of PDMS, including overcoat (1), administration channel (2), piezoelectric actuator (3), buffer pool (4), enter medicine passage (5), electromagnetic driver (6), medicament pond (9) and normally closed micro-valve (10), wherein normally closed micro-valve (10) is made up of valve block (7) and valve plug (8).Connection administration channel (2) on the right side of the overcoat (1)；The right side of the administration channel (2) is piezoelectric actuator (3), and medicine passage (2) and buffer pool (4) are connected respectively by normally closed micro-valve (10) at its both ends；Connected in the lower section of administration channel (2) by normally closed micro-valve (10) into medicine passage (5), enter one electromagnetic driver (6) of connection below medicine passage (5), electrical equipment drive device (6) lower section is connected to medicament pond (9) by normally closed micro-valve (10).The present invention uses flat micro-valve structure, overcome existing machinery decline pump multilayer labyrinth, also the reverse leakage of decoction can effectively be contained, the medication requirements of Millisecond are can reach, advantage, which is lain also in, is easy to Symptomatic medicine, and administration process is soft, also medicament backflow and the impact to affected part can be prevented, it is easy to carry, it is more succinct efficient, reduce cost.
Description
Technical field
The present invention relates to field of medical technology, is specifically that one kind is based on the micro- electromagnetism anal intestine postoperative administration devices of PDMS.
Background technology
Anorectal disease is frequently-occurring disease, such as anal fistula, hemorrhoid, colon cancer etc..Especially cut in anal fistula Post operation, low level anal fistula
Do not suture directly afterwards, but carry out medication, make based on its healing by second intention.Anorectal disease annoyings the strong of the mankind always for a long time
Health, how to solve and treat these diseases turns into the important topic that current scientific circles are faced, and is to study in the world at present
Focus and difficult point.Because operative site is easily by factors such as fecal pollution, defecation stimulations, to postoperative patient quality of life and wound
Hinder face healing belt and carry out certain harmful effect, the complication such as edge of wound oedema, pain, wound face secretion is more occur.
Administration process, huge peak cell quantity, wound face meat in by wound face secretion situation of change, wound face sepage printingout
The change of bud growth integration, wound face healing time etc., it is necessary to adjust dosage and medication duration in real time.
At present, conventional anorectum department therapeutic administration equipment is generally excessive (relative to nanoliter level) there is dosage, administration
Response time is slow (relative to Millisecond), and complex operation, the problems such as equipment costliness, can not be administered whenever and wherever possible.
In addition, in view of the development of microflow control technique at present, the process being administered using micro-valve are：Needed when using every time by medicine
Thing reagent and buffer solution are previously implanted into medicine passage and administration channel, then by external driving source enter to advance medicine and to
Medicine, lack integration, so being also inconvenient to use.How to reduce the reverse leakage of micro-valve in addition is also a problem, i.e., due to
The underpower of Micropump, medicament easily flow back.Therefore, postoperative complications how are reduced, mitigate patient suffering, promote post-surgical trauma
Long, promotion early recovery of looking unfamiliar is always the target that anal intestine circle medical care scientific worker makes great efforts.
The content of the invention
It is postoperative based on the micro- electromagnetism anal intestines of PDMS it is an object of the invention to provide one kind based on above-mentioned the deficiencies in the prior art
Doser, to solve the problems, such as to propose in background technology.
To achieve the above object, the present invention provides following technical scheme：One kind is based on the micro- electromagnetism anal intestine postoperative administrations of PDMS
Device, including overcoat 1, administration channel 2, piezoelectric actuator 3, buffer pool 4, enter medicine passage 5, electromagnetic driver 6, the and of medicament pond 9
Normally closed micro-valve 10.Wherein normally closed micro-valve 10 is made up of valve block 7 and valve plug 8, and using the PDMS plane micro-valves of zero clearance contact
Structure, can effective draining direction of flow, reduce the reverse leakage of liquid.
The right side of the overcoat 1 connection administration channel 2；The right side of the administration channel 2 is piezoelectric actuator 3, at its both ends
Medicine passage 2 and buffer pool 4 are connected by normally closed micro-valve 10 respectively；The lower section of administration channel 2 by normally closed micro-valve 10 connect into
Medicine passage 5, enters one electromagnetic driver 6 of the lower section of medicine passage 5 connection, and the lower section of electrical equipment drive device 6 is connected to by normally closed micro-valve 10
Medicament pond 9.
The electromagnetic driver 6 is four layers of encapsulating structure of PDMS electromagnetic drive Micropumps, and the superiors are a hollow structure
PDMS encapsulated layers 11, the lower section of the PDMS encapsulated layers 11 is provided with PDMS pumping diaphragms 13, and the lower section of the PDMS pumping diaphragms 13 connects
The PDMS pump housings 14, the lower section of the PDMS pump housings 14 are provided with PDMS substrate 17.
The surface of PDMS pumping diaphragms 13 is provided with a permalloy piece 12；It it is one in the bottom of PDMS pumping diaphragms 13
Silicon wafer layer 1303, the top of silicon wafer layer 1303 are provided with PE films 1302, and the top of PE films 1302 is provided with PDMS film 1301, PDMS
The top of film 1301 is provided with copper ion layer 1305, and the top of copper ion layer 1305 is provided with S1818 optical cements layer 1304, S1818 optical cement layers
Middle part opens up groove and is used for placing permalloy piece 12.
The middle part of the PDMS pump housings 14 is provided with a pump chamber 15, and the right side of pump chamber 15 is provided with a valve plug passage 16.
The further scheme of the present invention, the left side outlet of the overcoat 1 set the buffer dividing plate 101 of also one C-shaped.
The further scheme of the present invention, the permalloy piece 12 is the electricity in PDMS film 1301 by electroplating technology
Plating region deposits the driving piece for the one layer of about 20um to be formed.
The further scheme of the present invention, the electromagnetic driver 6 is four layers of PDMS encapsulating structures, close with peroxide glue
Envelope, its access way mouth connecting conduit.
Compared with prior art, the beneficial effects of the invention are as follows：Using flat micro-valve structure, pass through tetra- layers of demouldings of PDMS
Design and photoetching process combine, and have greatly played the gapless characteristic of tight fit of valve block 7 and valve plug 8, and micro-valve group
Reverse cutoff performance, overcome existing machinery and decline the labyrinth of pump multilayer, also can effectively contain the reverse leakage of decoction, can
Reach the medication requirements of Millisecond, meanwhile, dosage and time are accurately controlled, experiment shows can be within 60ms time
Reach the administration of 10-50nL trace drug reagents；Advantage, which is lain also in, is easy to Symptomatic medicine, and administration process is soft, C-shaped buffering knot
Structure, medicament backflow and the impact to affected part can be also prevented, is easy to carry, it is more succinct efficient, reduce cost.
Brief description of the drawings
Fig. 1 is a kind of general structure schematic diagram based on the micro- electromagnetism anal intestine postoperative administration devices of PDMS.
Fig. 2 is the operating diagram of present apparatus delivery system：Inactive state.
Fig. 3 is the operating diagram of present apparatus delivery system：Enter medicine state.
Fig. 4 is the operating diagram of present apparatus delivery system：Administration regime.
Fig. 5 is the structural representation of PDMS Micropump electromagnetic drives.
Fig. 6 be Fig. 5 in A-A sectional views, the fundamental diagram of electromagnetic driver.
Fig. 7 is the schematic layout pattern of perm alloy sheet and PDMS pumping diaphragms in Fig. 5.
Fig. 8 is the structural representation of PDMS pumping diaphragms.(wherein a, b, c are the order of implementing process flow)
Fig. 9 is the structural representation of micro-valve.
Figure 10 is the buffer structure schematic diagram at agent outlet in overcoat.
In figure：Overcoat 1；Buffer dividing plate 101；Administration channel 2；Piezoelectric actuator 3；Buffer pool 4；Enter medicine passage 5；Electromagnetism drives
Dynamic device 6；Valve block 7；Valve plug 8；Medicament pond 9；Normally closed micro-valve 10；PDMS encapsulated layers 11；Permalloy piece 12；PDMS pumping diaphragms 13；
PDMS film 1301；PE films 1302；Silicon wafer layer 1303；S1818 optical cements layer 1304；Copper ion layer 1305；The PDMS pump housings 14；Pump
Chamber 15；Valve plug passage 16；PDMS substrate 17.
Embodiment
Fig. 1-Figure 10 is referred to, in order that the above-mentioned technology contents and construction features of the present invention can be more easily by this areas
Those skilled in the art are understood that the present invention is described further with reference to technical essential and accompanying drawing.
Embodiment one：
A kind of micro- electromagnetism anal intestine postoperative administration devices of PDMS that are based on provided by the invention include, overcoat 1, administration channel 2, pressure
Electric drive 3, buffer pool 4, enter medicine passage 5, electromagnetic driver 6, medicament pond 9 and normally closed micro-valve 10.Wherein normally closed micro-valve 10 by
Valve block 7 and valve plug 8 form, and using the PDMS plane micro-valve structures of zero clearance contact, can effective draining direction of flow, reduction liquid
The reverse leakage of body.
The right side of the overcoat 1 connection administration channel 2；The right side of the administration channel 2 is piezoelectric actuator 3, at its both ends
Medicine passage 2 and buffer pool 4 are connected by normally closed micro-valve 10 respectively；The lower section of administration channel 2 by normally closed micro-valve 10 connect into
Medicine passage 5, enters one electromagnetic driver 6 of the lower section of medicine passage 5 connection, and the lower section of electrical equipment drive device 6 is connected to by normally closed micro-valve 10
Medicament pond 9.
The electromagnetic driver 6 is four layers of encapsulating structure of PDMS electromagnetic drive Micropumps, and the superiors are a hollow structure
PDMS encapsulated layers 11, the lower section of the PDMS encapsulated layers 11 is provided with PDMS pumping diaphragms 13, and the lower section of the PDMS pumping diaphragms 13 connects
The PDMS pump housings 14, the lower section of the PDMS pump housings 14 are provided with PDMS substrate 17.
The surface of PDMS pumping diaphragms 13 is provided with a permalloy piece 12；It it is one in the bottom of PDMS pumping diaphragms 13
Silicon wafer layer 1303, the top of silicon wafer layer 1303 are provided with PE films 1302, and the top of PE films 1302 is provided with PDMS film 1301, PDMS
The top of film 1301 is provided with copper ion layer 1305, and the top of copper ion layer 1305 is provided with S1818 optical cements layer 1304, S1818 optical cement layers
Middle part opens up groove and is used for placing permalloy piece 12.
The middle part of the PDMS pump housings 14 is provided with a pump chamber 15, and the right side of pump chamber 15 is provided with a valve plug passage 16.
The left side outlet of the overcoat 1 sets the buffer dividing plate 101 of also one C-shaped, for preventing and buffer fluid medicament
Impulsive force.
Embodiment two：
As shown in figure 5, can form malleation and negative pressure in the pump chamber 15 respectively, both easily cancel out each other after resonance, make
The net flow of Micropump substantially reduces, and is unfavorable for the outflow of medicament, therefore, in order to ensure there is enough propulsive forces, need to optimize reinforcement
Permalloy PDMS pumping diaphragms produce as far as possible big deformation dynamics under given magnetic field intensity.
The length of side on the basis of pumping diaphragm length of side A, permalloy structure and location parameter B, C, D are subjected to standardization processing,
The Young's modulus of permalloy piece and PDMS pumping diaphragms is set as：230GPa and 0.95MPa.Using CoMSOLMultiphysics's
The optimization data drawn after finite element analysis are：The length of side and height of pump chamber 15 are chosen for 5mm and 1800um, permalloy structure
It is respectively 0.15mm, 2.04mm and 0.6mm with location parameter B, C, D；The thickness of permalloy piece is 20um.
Embodiment three：
As shown in figure 8, the effect of the PE films 1302 be for PDMS pumping diaphragms 13 provide substrate support, be convenient for changing or from
Peeled off on silicon wafer layer.
The copper ion layer 1305 is to use electron beam transpiration method, and a layer thickness deposited on PDMS film 1301 is about
50um copper metal ion, its role is to ensure there are enough bonding forces between permalloy piece 12 and PDMS pumping diaphragms 13, prevent
The permalloy piece only electroplated comes off in electroplating process.
The S1818 optical cements layer is thickness 20um photoresist, forms the permalloy electroplating region as shown in Fig. 8 (b)
Domain.
The permalloy piece 12 is that to be formed one layer is deposited in the plating area of PDMS film 1301 by electroplating technology
About 20um driving piece.
Example IV：
As shown in figure 5, in the micro- electromagnetic drive designs of PDMS, four layers of PDMS pieces of the electromagnetic driver 6, it encapsulates main
Using plasma oxidation treatment method, completed in ion reaction etching machine.Four layers are completed according to order from the bottom up
The sealing of PDMS pieces, and be placed on hot plate and heated 12 minutes with 80 DEG C of temperature, seal PDMS, finally, electromagnetic driver 6 enters
Go out passway connecting conduit, with peroxide glue sealing.
Embodiment five：
The externally-applied magnetic field of the electromagnetic driver 6, electromagnetic controller (the E363IA models of remote control can be used
Agilellt), programmed using computer Labview and control the opening and closing time of power supply, produced and believe into medicine pulsed
Number or administration pulsed signal, so as to realize the remote control to entering medicine process and administration process.
One kind is based on the micro- electromagnetism anal intestine postoperative administration device operation principles of PDMS：
As shown in Fig. 6 fundamental diagrams, under inactive state, during the micro- electromagnetic drives of PDMS, no externally-applied magnetic field acts on
On permalloy piece 12, therefore pumping diaphragm does not deform, in smooth holding state.
At any driving condition, permalloy piece 12 issues magnetisation in additional magnetic fields, and with the magnetic field of vertical direction
Interaction produces magnetic torque, drives PDMS pumping diaphragms 13 to deform, and so as to change the volume of pump chamber 15 and pressure, and then drives
Fluid.Equally, the alternating magnetic field to be moved in circles by application, acts on electromagnetic driver 6, produces pumping diaphragm of reciprocating vibration, then
Coordinate the traffic organising effect of micro-valve 10, realize the unidirectional continuous flowing of fluid medicament.By entering medicine passage and administration channel
Arrival end applies control wave, is accurately manipulated to entering medicine and administration process, when realizing to administration amount of reagent and administration
Between accurate control.
Described above is only the preferred embodiment of the present invention, is not intended to limit the scope of the invention, and should be referred to
Go out, for those skilled in the art, under the premise without departing from the principles of the invention, can also make some
Improvements and modifications, these improvements and modifications should also regard protection scope of the present invention.
Claims (4)
1. one kind is based on the micro- electromagnetism anal intestine postoperative administration devices of PDMS, including overcoat (1), administration channel (2), piezoelectric actuator
(3), buffer pool (4), enter medicine passage (5), electromagnetic driver (6), medicament pond (9) and normally closed micro-valve (10)；It is characterized in that：Institute
Normally closed micro-valve (10) is stated to be made up of valve block (7) and valve plug (8), and using the PDMS plane micro-valve structures of zero clearance contact；Institute
State connection administration channel (2) on the right side of overcoat (1)；The right side of the administration channel (2) is piezoelectric actuator (3), is led at its both ends
Cross normally closed micro-valve (10) and connect medicine passage (2) and buffer pool (4) respectively；Pass through normally closed micro-valve in the lower section of administration channel (2)
(10) connect into medicine passage (5), enter one electromagnetic driver (6) of connection below medicine passage (5), lead to below electrical equipment drive device (6)
Cross normally closed micro-valve (10) and be connected to medicament pond (9)；
The electromagnetic driver (6) is four layers of encapsulating structure of PDMS electromagnetic drive Micropumps, and the superiors are a hollow structure
PDMS encapsulated layers (11), PDMS encapsulated layers (11) lower section are provided with PDMS pumping diaphragms (13), the lower section of the PDMS pumping diaphragms (13)
The PDMS pump housings (14) are connected, PDMS substrate (17) is provided with below the PDMS pump housings (14)；
PDMS pumping diaphragms (13) surface is provided with a permalloy piece (12)；It is one in the bottom of PDMS pumping diaphragms (13)
Individual silicon wafer layer (1303), the top of silicon wafer layer (1303) are provided with PE films (1302), and it is thin to be provided with PDMS above PE films (1302)
Film (1301), PDMS film (1301) top are provided with copper ion layer (1305), S1818 optical cements are provided with above copper ion layer (1305)
Layer (1304), S1818 optical cements layer middle part open up groove and are used for placing permalloy piece (12)；
A pump chamber (15) is provided with the middle part of the PDMS pump housings (14), the right side of pump chamber (15) is provided with a valve plug passage (16).
2. one kind according to claim 1 is based on the micro- electromagnetism anal intestine postoperative administration devices of PDMS, it is characterised in that：It is described outer
The left side outlet of set (1) sets the buffer dividing plate (101) of also one C-shaped.
3. one kind according to claim 1 is based on the micro- electromagnetism anal intestine postoperative administration devices of PDMS, it is characterised in that：The slope
Alloy sheet (12) is not to deposit to be formed one layer of 20um driving in the plating area of PDMS film (1301) by electroplating technology
Piece.
4. one kind according to claim 1 is based on the micro- electromagnetism anal intestine postoperative administration devices of PDMS, it is characterised in that：The electricity
Magnetic driven device (6) is four layers of PDMS encapsulating structures, with peroxide glue sealing, its access way mouth connecting conduit.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710734299.7A CN107569764B (en) | 2017-08-24 | 2017-08-24 | Based on little electromagnetism anus intestines postoperative device of dosing of PDMS |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710734299.7A CN107569764B (en) | 2017-08-24 | 2017-08-24 | Based on little electromagnetism anus intestines postoperative device of dosing of PDMS |
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| Publication Number | Publication Date |
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| CN107569764A true CN107569764A (en) | 2018-01-12 |
| CN107569764B CN107569764B (en) | 2020-04-21 |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005031165A1 (en) * | 2003-10-01 | 2005-04-07 | Agency For Science, Technology And Research | Micro-pump |
| US20090137874A1 (en) * | 2007-11-26 | 2009-05-28 | The Hong Kong Polytechnic University | Polymer Microvalve with actuators and devices |
| CN102817818A (en) * | 2012-08-30 | 2012-12-12 | 清华大学 | Electrolysis micropump for double-fluid synchronous transmission |
| CN103282706A (en) * | 2011-01-21 | 2013-09-04 | 比奥卡尔齐什股份有限公司 | Micro-pump or normally-ff micro-valve |
| CN105715865A (en) * | 2016-03-24 | 2016-06-29 | 中国科学院理化技术研究所 | Electromagnetic micro-valve device |
| CN206206740U (en) * | 2016-10-11 | 2017-05-31 | 昆明理工大学 | A kind of Electromagnetic Drive fluid miniature valve |
-
2017
- 2017-08-24 CN CN201710734299.7A patent/CN107569764B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005031165A1 (en) * | 2003-10-01 | 2005-04-07 | Agency For Science, Technology And Research | Micro-pump |
| US20090137874A1 (en) * | 2007-11-26 | 2009-05-28 | The Hong Kong Polytechnic University | Polymer Microvalve with actuators and devices |
| CN103282706A (en) * | 2011-01-21 | 2013-09-04 | 比奥卡尔齐什股份有限公司 | Micro-pump or normally-ff micro-valve |
| CN102817818A (en) * | 2012-08-30 | 2012-12-12 | 清华大学 | Electrolysis micropump for double-fluid synchronous transmission |
| CN105715865A (en) * | 2016-03-24 | 2016-06-29 | 中国科学院理化技术研究所 | Electromagnetic micro-valve device |
| CN206206740U (en) * | 2016-10-11 | 2017-05-31 | 昆明理工大学 | A kind of Electromagnetic Drive fluid miniature valve |
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| CN107569764B (en) | 2020-04-21 |
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Effective date of registration: 20220920 Address after: 050000 No. 215 Heping West Road, Hebei, Shijiazhuang Patentee after: THE SECOND HOSPITAL OF HEBEI MEDICAL University Address before: Department of Anorectal Surgery, Second Hospital of Hebei Medical University, No. 215, Heping West Road, Xinhua District, Shijiazhuang City, Hebei Province, 053000 Patentee before: Ren Pengtao |
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