CN107537099A - A kind of evaluation method of high intensity focused ultrasound energy effect - Google Patents
A kind of evaluation method of high intensity focused ultrasound energy effect Download PDFInfo
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- CN107537099A CN107537099A CN201610479646.1A CN201610479646A CN107537099A CN 107537099 A CN107537099 A CN 107537099A CN 201610479646 A CN201610479646 A CN 201610479646A CN 107537099 A CN107537099 A CN 107537099A
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Abstract
The present invention provides a kind of evaluation method of high intensity focused ultrasound energy effect, belongs to high intensity focused ultrasound technical field, its can solve the problems, such as it is existing can not quantitatively evaluating high intensity focused ultrasound focus energy effect.The evaluation method of the high intensity focused ultrasound energy effect of the present invention is to form digitized focal regions energy effect data, single measurement model focal regions energy effect data compared with the model focal regions energy effect normal data by the formation of statistics, judge whether high intensity focused ultrasound energy and focal regions energy effect are normal, realize the quantitatively evaluating to focal regions energy effect.This method test data is stable, can be with the energy effect of accurate quantification focal regions, beneficial to the focusing performance and positioning precision of operator's accurate judgement high intensity focused ultrasound.The evaluation method of the high intensity focused ultrasound energy effect of the present invention is applied to evaluate various high intensity focused ultrasound energies.
Description
Technical field
The invention belongs to high intensity focused ultrasound technical field, and in particular to a kind of high intensity focused ultrasound energy effect
Evaluation method.
Background technology
It is swollen using high intensity focused ultrasound (High Intensity Focused Ultrasound, abbreviation HIFU) treatment
Knurl is a kind of physical therapeutic technic developed rapidly in recent years.Specifically, in HIFU Treatment, ultrasonic transducer is by this ultrasound
For Voice segment at the destination organization of tumor focus, ultrasonic energy produces fuel factor, mechanical effect, cavitation effect in the focal point
And sonochemical effect, destination organization is produced irreversible coagulation necrosis, so as to reach the purpose of ablation entity tumor focus.
Therefore, the security of HIFU Treatment and validity and HIFU energy effect (such as focusing performance and positioning precision) close phase
Close.
But the test of HIFU energy effect has no unified testing standard or method for quantitatively evaluating.Wherein, sound field is surveyed
Method for testing, generally use Free field measurement system are tested in laboratory, although the test system test is strongly professional, its phase
To costliness；Radiation pressure method needs the experimenter by specialty to be tested, and this method is high to the environmental requirement of test, during measurement
Between it is long；The test material preparation of beef liver method of testing is more complicated, and the uniformity of its test result is poor；And above to focusing on
The operator (clinician) that the method for testing of ultrasonic energy is not suitable for non-experiment specialty uses in clinical practice.
At present, it is generally external in patient in practical clinical, using bionical body mould (or lucite, acrylic) mould
Intend patient, HIFU energy effect is tested by physical method.In High Intensity Focused Ultrasound body mould, body mould is due to by super
Acoustic energy, focal regions part can be heated and generation property becomes, and cause the appearance color change of body mould, operator can by observe color change interval come
Judge focus energy effect.
Inventor has found that at least there are the following problems in the prior art：In the energy of the high intensity focused ultrasound of equal-wattage
Under irradiation, the size of body mould color change interval and differing greatly for color changeable effect, test data is unstable, can not accurate evaluation quantization
The energy effect of focal regions.
The content of the invention
The present invention for it is existing can not accurate quantification evaluation high intensity focused ultrasound focus energy effect the problem of, carry
For a kind of evaluation method of high intensity focused ultrasound energy effect.
Technical scheme is used by solving present invention problem：
A kind of evaluation method of high intensity focused ultrasound energy effect, including obtain the step of model focal regions energy effect data
Suddenly, the step model focal regions energy effect normal data that model focal regions energy effect data and same experimental conditions obtain contrasted
Suddenly.
Preferably, the acquisition model focal regions energy effect normal data comprises the following steps：
Model is fixed in the container of holding liquid vertically, at least one target location is set on model；
Energy is exported to each target location using high intensity focused ultrasound；
Gather the grey scale change image of each target location of model；
Extract the focal regions energy effect data of grey scale change image；
Repeat the above steps to obtain multiple focal regions energy effect data, ask being averaged for multiple focal regions energy effect data
It is worth exemplarily focal regions energy effect normal data.
Preferably, the acquisition model focal regions energy effect data comprise the following steps：
High intensity focused ultrasound is set to export energy to each target location；
Gather the grey scale change image of each target location of model；
Extract the focal regions energy effect data of grey scale change image.
Preferably, the focal regions energy effect data include the contour area data of grey scale change image, grey scale change
The major axis data of the profile of image, and the volume data of focal regions.
Preferably, the volume data of the focal regions is prepared by the following：
Sketch the contours the profile of grey scale change image；
Extract the major axis data of profile；
Profile is rotated by major axis to obtain the volume data of profile.
Preferably, the experiment condition includes high intensity focused ultrasound output energy work rate, exposure time.
Preferably, the high intensity focused ultrasound output energy work rate is 100-400W；The exposure time is 1-2S.
Preferably, at least n target location is set on the model, wherein, n >=1；The high intensity focused ultrasound to
Each target location exports different energy work rates, and different energy work rates be high intensity focused ultrasound from specified minimum value to
Energy work rate between maximum.
Preferably, the model is made up of lucite or bionical body mould.
Preferably, the model thickness is 1-4mm.
Wherein, lucite is polymethyl methacrylate (PMMA), by monomer methacrylic acid formicester (MMA) polymerization
Into, it is a kind of thermoplastic, density 1.19--1.20, there is high transparency, the weatherability and resistance to ag(e)ing with protrusion.
Its glass transition temperature Tg is typically at 104 DEG C.Test sample plate meets GBT 7134-2008 casting type industry methacrylate sheets
Technical indicator.
The evaluation method of the high intensity focused ultrasound energy effect of the present invention, is to form digitized focal regions energy effect number
According to single measurement model focal regions energy effect data and the model focal regions energy effect normal data ratio by counting formation
Compared with judging whether high intensity focused ultrasound energy and focal regions energy effect are normal, realize the quantitatively evaluating to focal regions energy effect.
This method test data is stable, can be high-strength focused super beneficial to operator's accurate judgement with the energy effect of accurate quantification focal regions
The focusing performance and positioning precision of sound.It is various that the evaluation method of the high intensity focused ultrasound energy effect of the present invention is applied to evaluation
High intensity focused ultrasound energy.
Brief description of the drawings
Fig. 1, Fig. 2 are the evaluation method test chart of the high intensity focused ultrasound energy effect of embodiments of the invention 2；
Wherein, reference is：1st, profile；2nd, major axis；3rd, short axle.
Embodiment
To make those skilled in the art more fully understand technical scheme, below in conjunction with the accompanying drawings and specific embodiment party
Formula is described in further detail to the present invention.
Embodiment 1：
The present embodiment provides a kind of evaluation method of high intensity focused ultrasound energy effect, including obtains model focal regions energy
The step of effect data, the model focal regions energy effect standard that model focal regions energy effect data and same experimental conditions are obtained
The step of data comparison.
The evaluation method of the high intensity focused ultrasound energy effect of the present embodiment, it is to form digitized focal regions energy effect
Data, single measurement model focal regions energy effect data and the model focal regions energy effect normal data of the formation by statistics
Compare, judge whether high intensity focused ultrasound energy and focal regions energy effect are normal, realize that the quantization to focal regions energy effect is commented
Valency.This method test data is stable, can be high-strength focused beneficial to operator's accurate judgement with the energy effect of accurate quantification focal regions
The focusing performance and positioning precision of ultrasound.The evaluation method of the high intensity focused ultrasound energy effect of the present embodiment is applied to evaluation
Various high intensity focused ultrasound energies.
Embodiment 2：
The present embodiment provides a kind of evaluation method of high intensity focused ultrasound energy effect, comprises the following steps：
S1, test sample plate focal regions energy effect normal data：
S101, model is fixed in the tank being filled with water, five target locations are set on model；Wherein, model is by having
Machine glass is formed, thickness 2-4mm.
S102, using high intensity focused ultrasound respectively to each target location export energy, focal regions energy effect can be in sample
Plate produces multiple different physical change regions shown in Fig. 1.Wherein, the power for exporting energy is 100-400W；Exposure time
For 1S.Specifically, ultrasonic transducer can be used to export the different high intensity focused ultrasound of energy work rate to five target locations,
It is the specified minimum value of high intensity focused ultrasound that it, which exports the minimum value of energy work rate, and it is high-strength that it, which exports the maximum of energy work rate,
Degree focuses on ultrasonic rated maximum, remaining different numerical value between specified minimum value and rated maximum.For example, to five
Target location exports energy work rate：100W、200W、250W、300W、400W.
S103, gather model each target location grey scale change image；
Specifically, camera or the first-class equipment shooting image of shooting can be used, and should be used during shooting image
Arbitrary source, the interference of external environment light is avoided, ensure the accuracy of the data of IMAQ.Photograph or picture pick-up device be not low
In 2,000,000 pixels.
S104, the focal regions energy effect data for extracting grey scale change image；
, wherein it is desired to the area data of image outline is extracted, and the major axis data (short axle data) of the profile of image, Yi Jijiao
The volume data in domain.
Specifically, image processing software sketches the contours extraction to digital image outline, using image processing algorithm such as threshold value point
Cut or region increases, level set etc. can be realized, after extracting profile, can be obtained using the method for computing mechanism numerical integration
Major axis short axle data to contour area and with profile, and the volume that is calculated of rotation is carried out with its major axis.Volume calculates public
Formula is mainly according to the mode of integration summation：
Wherein, limes superiors H is long electrical path length, and PI is pi constant 3.1415926, and R is that focal regions profile corresponds to longitudinal position
Put H0 (0<=H0<=H) place lateral length value W half, the radius of a circle R at as current H0.
S105, the step of above-mentioned S101-S104 is repeated, obtain multiple focal regions energy effect data, seek multiple focal regions
The average value of energy effect data exemplarily focal regions energy effect normal data.
S2, test high intensity focused ultrasound to be detected radiate above-mentioned model focal regions energy effect data：
S201, energy, focal regions energy dose-effect exported to each target location using high intensity focused ultrasound to be detected
Multiple different physical change regions shown in Fig. 2 should can be produced in model.Wherein, the power for exporting energy is 100-400W；
Exposure time is 1S.It is understood that high intensity focused ultrasound to be detected in S201 steps is to each target location
Exporting should be identical with exporting energy in S102 steps on energy theory, in order to follow-up contrast.For example, to five target locations
Exporting energy work rate can be respectively：100W、200W、250W、300W、400W.
S202, gather model each target location grey scale change image；The step is similar with the operation in S103,
Do not repeated at this.
S203, the focal regions energy effect data for extracting grey scale change image.Specifically, image processing software can be used to hook
The profile for strangling grey scale change image obtains its area and length (short) number of axle evidence；Profile is obtained into the body of profile by major axis rotation processing
Volume data.Wherein, the W obtained in Fig. 2 using software processing represents short axle data, and H represents major axis data, and V represents volume data.
S3, by model focal regions energy effect data that S2 is obtained and the model focal regions energy that is obtained in same experimental conditions S1
Effect normal data contrasts, if the model focal regions energy effect data that S2 is obtained are more than the normal data that S1 is obtained, ultrasound
Transducer or driving equipment output energy are excessive, if the model focal regions energy effect data that S2 is obtained are less than the standard that S1 is obtained
Data, then ultrasonic transducer or driving equipment output energy are insufficient, if model focal regions energy effect data and S1 that S2 is obtained
Obtained normal data is identical or close to (in error allowed band), then ultrasonic transducer or driving equipment are exporting energy just
Often.
It is understood that when being tested for the first time, it is necessary to carry out S1 model focal regions energy effect normal data
Test, after S1 normal data is obtained, when being detected again under the same terms, it is only necessary to carry out S2 high intensity focused ultrasound radiation
Above-mentioned model focal regions energy effect data test, that is to say, that without surveying S1 normal data every time.
Obviously, also many modifications may be made to for the embodiment of the various embodiments described above；Such as：The test time of normal data
Number can be adjusted as needed, and the statistical of normal data can be with flexible and changeable.
It is understood that the principle that embodiment of above is intended to be merely illustrative of the present and the exemplary implementation that uses
Mode, but the invention is not limited in this.For those skilled in the art, the essence of the present invention is not being departed from
In the case of refreshing and essence, various changes and modifications can be made therein, and these variations and modifications are also considered as protection scope of the present invention.
Claims (10)
1. a kind of evaluation method of high intensity focused ultrasound energy effect, it is characterised in that including obtaining model focal regions energy dose-effect
The step of answering data, the model focal regions energy effect criterion numeral that model focal regions energy effect data and same experimental conditions are obtained
The step of according to contrast.
2. the evaluation method of high intensity focused ultrasound energy effect according to claim 1, it is characterised in that the acquisition
Model focal regions energy effect normal data comprises the following steps：
Model is fixed in the container of holding liquid vertically, at least one target location is set on model；
Energy is exported to each target location using high intensity focused ultrasound；
Gather the grey scale change image of each target location of model；
Extract the focal regions energy effect data of grey scale change image；
Repeat the above steps to obtain multiple focal regions energy effect data, ask the average value of multiple focal regions energy effect data to make
For model focal regions energy effect normal data.
3. the evaluation method of high intensity focused ultrasound energy effect according to claim 2, it is characterised in that the acquisition
Model focal regions energy effect data comprise the following steps：
High intensity focused ultrasound is set to export energy to each target location；
Gather the grey scale change image of each target location of model；
Extract the focal regions energy effect data of grey scale change image.
4. the evaluation method of the high intensity focused ultrasound energy effect according to Claims 2 or 3, it is characterised in that described
Focal regions energy effect data include the contour area data of grey scale change image, the major axis data of the profile of grey scale change image,
And the volume data of focal regions.
5. the evaluation method of high intensity focused ultrasound energy effect according to claim 4, it is characterised in that the focal regions
Volume data be prepared by the following：
Sketch the contours the profile of grey scale change image；
Extract the major axis data of profile；
Profile is rotated by major axis to obtain the volume data of profile.
6. the evaluation method of high intensity focused ultrasound energy effect according to claim 1, it is characterised in that the experiment
Condition includes high intensity focused ultrasound output energy work rate, exposure time.
7. the evaluation method of high intensity focused ultrasound energy effect according to claim 6, it is characterised in that described high-strength
It is 100-400W that degree, which focuses on ultrasound output energy work rate,；The exposure time is 1-2S.
8. the evaluation method of high intensity focused ultrasound energy effect according to claim 2, it is characterised in that the model
Upper setting at least n target location, wherein, n >=1；The high intensity focused ultrasound exports different energy to each target location
Measure power, and different energy work rates be high intensity focused ultrasound from specified minimum value to the energy work rate maximum.
9. the evaluation method of high intensity focused ultrasound energy effect according to claim 1, it is characterised in that the model
It is made up of lucite or bionical body mould.
10. the evaluation method of high intensity focused ultrasound energy effect according to claim 1, it is characterised in that the sample
Plate thickness is 1-4mm.
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| CN105251142A (en) * | 2015-11-13 | 2016-01-20 | 浙江大学 | Preventive maintenance method of high intensity focused ultrasound (HIFU) equipment |
| CN105435380A (en) * | 2015-11-13 | 2016-03-30 | 浙江大学 | Risk assessment method for HIFU treatment equipment based on inverse heat conduction |
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2016
- 2016-06-27 CN CN201610479646.1A patent/CN107537099B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20040152984A1 (en) * | 2000-09-29 | 2004-08-05 | New Health Sciences | Decision support systems and methods for assessing vascular health |
| US20040087856A1 (en) * | 2002-11-01 | 2004-05-06 | Satchi Panda | Method and apparatus for B-mode image banding suppression |
| CN1803224A (en) * | 2005-01-10 | 2006-07-19 | 重庆海扶(Hifu)技术有限公司 | High intensity focused ultrasound therapy apparatus and method |
| CN104837527A (en) * | 2012-04-12 | 2015-08-12 | 皇家飞利浦有限公司 | High-intensity focused ultrasound for heating a target zone larger than the electronic focusing zone |
| CN105251142A (en) * | 2015-11-13 | 2016-01-20 | 浙江大学 | Preventive maintenance method of high intensity focused ultrasound (HIFU) equipment |
| CN105435380A (en) * | 2015-11-13 | 2016-03-30 | 浙江大学 | Risk assessment method for HIFU treatment equipment based on inverse heat conduction |
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