CN107536851A - The preparation technology and Moschus piece of Moschus - Google Patents
The preparation technology and Moschus piece of Moschus Download PDFInfo
- Publication number
- CN107536851A CN107536851A CN201710951635.3A CN201710951635A CN107536851A CN 107536851 A CN107536851 A CN 107536851A CN 201710951635 A CN201710951635 A CN 201710951635A CN 107536851 A CN107536851 A CN 107536851A
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- Prior art keywords
- moschus
- fresh
- parts
- preparation technology
- composite preservative
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- 241000972155 Moschus Species 0.000 title claims abstract description 228
- 238000005516 engineering process Methods 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- 239000003755 preservative agent Substances 0.000 claims abstract description 77
- 230000002335 preservative effect Effects 0.000 claims abstract description 77
- 239000002131 composite material Substances 0.000 claims abstract description 57
- 238000007789 sealing Methods 0.000 claims abstract description 47
- 238000004108 freeze drying Methods 0.000 claims abstract description 26
- 239000007789 gas Substances 0.000 claims description 37
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 32
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 27
- 239000000341 volatile oil Substances 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 229910052757 nitrogen Inorganic materials 0.000 claims description 15
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 13
- 239000001569 carbon dioxide Substances 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 11
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 10
- 229920001661 Chitosan Polymers 0.000 claims description 10
- 235000001405 Artemisia annua Nutrition 0.000 claims description 9
- 240000000011 Artemisia annua Species 0.000 claims description 9
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims description 9
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 9
- 235000013824 polyphenols Nutrition 0.000 claims description 9
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 claims description 7
- 239000010634 clove oil Substances 0.000 claims description 7
- 239000003643 water by type Substances 0.000 claims description 7
- 241001416180 Moschidae Species 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 5
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 5
- 229930003268 Vitamin C Natural products 0.000 claims description 5
- 239000001110 calcium chloride Substances 0.000 claims description 5
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 5
- 239000011718 vitamin C Substances 0.000 claims description 5
- 235000019154 vitamin C Nutrition 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 3
- OKTJSMMVPCPJKN-YPZZEJLDSA-N carbon-10 atom Chemical group [10C] OKTJSMMVPCPJKN-YPZZEJLDSA-N 0.000 claims 1
- 229940126678 chinese medicines Drugs 0.000 abstract description 2
- 229960004424 carbon dioxide Drugs 0.000 description 13
- 230000000694 effects Effects 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 238000007654 immersion Methods 0.000 description 5
- 239000010410 layer Substances 0.000 description 5
- 239000003921 oil Substances 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 150000003722 vitamin derivatives Chemical class 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 238000004821 distillation Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000002304 perfume Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- 229910001873 dinitrogen Inorganic materials 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000003694 hair properties Effects 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- ALHUZKCOMYUFRB-UHFFFAOYSA-N muskone Natural products CC1CCCCCCCCCCCCC(=O)C1 ALHUZKCOMYUFRB-UHFFFAOYSA-N 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 235000013599 spices Nutrition 0.000 description 2
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 206010020852 Hypertonia Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000972191 Moschus berezovskii Species 0.000 description 1
- 241000972170 Moschus moschiferus Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 241000207929 Scutellaria Species 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000001099 ammonium carbonate Substances 0.000 description 1
- 235000012501 ammonium carbonate Nutrition 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229910002090 carbon oxide Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 230000006318 protein oxidation Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Abstract
The present invention relates to the field of Chinese medicines, and the preparation technology and Moschus piece of more particularly to a kind of Moschus.The present invention proposes a kind of preparation technology of Moschus, comprises the following steps:Fresh Moschus and composite preservative are mixed to get Moschus of the surface covered with preservative film, it is fresh-keeping in the sealing container with fresh-keeping gas by being positioned over again after Moschus freeze-drying of the surface covered with preservative film.It can keep the active component in Moschus not lose, while can, extend holding time of Moschus.
Description
Technical field
The present invention relates to the field of Chinese medicines, and the preparation technology and Moschus piece of more particularly to a kind of Moschus.
Background technology
Moschus is musk deer section animal woods musk deer Moschus berezovskii Flerov. horse musk deers
Drying secretion in M.sifanicusPrzewalski or former musk deer M.moschiferus L. hero body note capsules.A kind of and medicine
Material, also known as very little fragrant, member cun, when the door, smelly sub, fragrant navel.Its warm-natured acrid flavour, enters the heart, spleen, Liver Channel.Have one's ideas straightened out, invigorate blood circulation, dissipating bind, only
Bitterly.Moschus mainly contains moisture 23.56%, ash content 3.62% (wherein containing potassium, sodium, calcium, magnesium, iron, chlorine, sulfate radical, phosphate radical from
Son etc.), and oxygenatedchemicals (wherein containing ammonium carbonate 1.15%, the ammonia 1.89% in ammonium salt, urea 0.40%, amino acid nitrogen
1.07%, nitrogen pool 9.15%), cholesterine 2.19%, crude fibre 0.59%, aliphatic acid 6.15%, muskone 2.2%.Moschus
Principle active component is muskone.Active component in Moschus contains substantial amounts of volatile oil, using existing dry technology to musk deer
Perfume (or spice) carries out the loss that drying easily causes the active component in Moschus, then reduces the drug effect of Moschus.
The content of the invention
It is an object of the invention to provide a kind of preparation technology of Moschus, and it can keep the active component in Moschus not lose
Lose, while can, extend holding time of Moschus.
Another object of the present invention is to provide a kind of Moschus piece, each active component content of the Moschus piece is high and preserves
Time is grown.
The present invention is solved its technical problem and realized using following technical scheme：
The present invention proposes a kind of preparation technology of Moschus, comprises the following steps:Fresh Moschus is mixed with composite preservative
To Moschus of the surface covered with preservative film, will be positioned over again with guarantor after Moschus freeze-drying of the surface covered with preservative film
It is fresh-keeping in the sealing container of fresh gas.
In parts by weight, the composite preservative include 60-80 parts chitosan, 100-120 parts water, 30-50 parts Tea Polyphenols,
5-10 parts vitamin C, 1-3 parts edible salt, 3-5 parts clove oil, 3-5 parts artemisia annua essential oil and 1-3 part kamuning essential oils.
The present invention proposes a kind of Moschus piece, and it is prepared by the preparation technology of above-mentioned Moschus.
The beneficial effect of scutellaria tablet of the present invention is：The preparation technology of Moschus of the present invention is using composite preservative on Moschus surface
Forming one layer of preservative film prevents air from being contacted with Moschus, prevents Moschus from going bad, extends the holding time of Moschus.While preservative film is also
The volatilization of volatile active in Moschus can be reduced, lifts the content of active component in Moschus.Then utilize freeze-drying
Go the water for removing fresh Moschus surface and inside, further reduce the volatilization of volatile ingredient in Moschus, while promote multiple
The adhesive force of antistaling agent and Moschus is closed, further extends the holding time of Moschus.Then Moschus is positioned over fresh-keeping sky
In the sealing container of gas, exchanging for Moschus and the matter of air can be further reduced, further lifts active component in Moschus
Content.
Embodiment
, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer
Technical scheme be clearly and completely described.Unreceipted actual conditions person, builds according to normal condition or manufacturer in embodiment
The condition of view is carried out.Agents useful for same or the unreceipted production firm person of instrument, it is the conventional production that can be obtained by commercially available purchase
Product.
In the description of the invention, it is necessary to which explanation, term " first ", " second " etc. are only used for distinguishing description, without
It is understood that to indicate or implying relative importance.
The preparation technology and Moschus piece of the Moschus of the embodiment of the present invention are specifically described below.
A kind of preparation technology of Moschus provided in an embodiment of the present invention, comprises the following steps：
S1, prepare composite preservative；
In parts by weight, composite preservative includes 60-80 parts chitosan, 100-120 parts water, 30-50 parts Tea Polyphenols, 5-10
Part vitamin C, 1-3 parts edible salt, 3-5 parts clove oil, 3-5 parts artemisia annua essential oil and 1-3 part kamuning essential oils.That is composite fresh-keeping
The preparation of agent is to be mixed above-mentioned each raw material according to aforementioned proportion, without specific order by merging, it is only necessary to will be above-mentioned each
Raw material mixing with.It is above-mentioned mutually to be acted synergistically using aforementioned proportion, form one layer of preservative film on fresh Moschus surface
Contact of the Moschus with air can effectively be completely cut off, prevent Moschus from going bad, while the volatilization of active volatile oil in Moschus can be slowed down,
Then ensure that the content of the active component in Moschus will not be reduced, and the holding time of Moschus can be extended.
Tea Polyphenols can effectively suppress the oxidation of Moschus internal oxidition material, vitamin C can further anti-oxidation, food
The part germ on Moschus surface can be killed with salt, meanwhile, the holding time of bacteria growing inhibiting, further extension Moschus, and
Caryophyllus oil, artemisia annua essential oil and kamuning essential oil, which are attached to Moschus surface, also can suppress different types of germ and bacterium life
It is long, prevent that Moschus is corrupt, meanwhile, the volatilization of the active volatile oil in Moschus can be suppressed, lift active component in Moschus
Content.The effect of chitosan contributes to caryophyllus oil, artemisia annua essential oil and kamuning essential oil to be attached to Moschus surfaced lift each essential oil,
Chitosan contributes to Tea Polyphenols, vitamin C to form preservative film on Moschus surface simultaneously, prevents air from being contacted with Moschus, then prolongs
The holding time of long Moschus.
Further, composite preservative also includes 1-2 part calcium chloride.Calcium chloride further helps in be formed on Moschus surface
Preservative film, further prevent air from being contacted with Moschus with effects such as chitosans so that with air exchanging for matter will not occur for Moschus,
Delay the volatilization of active volatile oil in Moschus simultaneously.
S2, fresh Moschus mix with composite preservative；
Fresh Moschus and composite preservative are mixed to get Moschus of the surface covered with preservative film.Specifically by fresh Moschus
It is positioned in composite preservative and is soaked.Each active ingredient of composite preservative is adhered to and fresh Moschus surface.
Further, when composite preservative mixes with fresh Moschus, to the mixture of composite preservative and fresh Moschus in be passed through
Ozone.Ozone part ozone is passed through to be soluble in water then to fresh Moschus surface progress sterilization processing, meanwhile, it is capable to part
Ozone may be also attached to the volatilization that Moschus surface further suppresses active component in Moschus.Further, the concentration of ozone is
3-10ppm。
Further, the mixing to composite preservative and fresh Moschus is ultrasonically treated.Supersound process can strengthen compound
The adhesion of antistaling agent and fresh Moschus, it is easy to composite preservative to be attached to composite preservative surface, while ultrasound can be beneficial to again
Close the well mixed of each composition in antistaling agent, then ensure the composite preservative of fresh Moschus surface attachment composition it is consistent,
Then it ensure that composite preservative to the fresh-keeping of Moschus and the effect of holding Moschus composition.
Further, the time that fresh Moschus mixes with composite preservative is 15-30 minutes.I.e. fresh Moschus is in composite preservative
Interior immersion 15-30 minutes so that composite preservative can be contacted fully with fresh Moschus, then ensure composite preservative with being attached to
The amount on fresh Moschus surface, protection effect of the lifting composite preservative to Moschus.
S3, freeze-drying；
Moschus of the surface covered with preservative film is freeze-dried.Freeze-drying is by fresh Moschus surface and fresh Moschus
Internal moisture removal, without removing the active volatile material in fresh Moschus.Specifically, Moschus freeze-drying is in -30--
3-5 minutes are freezed at a temperature of 20 DEG C, 15-30 minutes are then dried in 0-5 DEG C of environment respectively, in 25-35 DEG C of environment
Dry 30-45 minutes.The fresh Moschus surface of -30--20 DEG C of temperature moisture (including composite preservative attachment with fresh Moschus table
The moisture in face) and fresh Moschus in moisture can be frozen into sleet rapidly, then in 0-5 DEG C of environment dry 15-30
It is vaporous water that minute, which can directly distil the solid water on fresh Moschus surface, so that fresh Moschus is dry and hard, while composite preservative exists
The protective layer that dry and hard Moschus surface forms one layer of solid-state is preservative film, prevents air from being contacted with Moschus surface, while can press down
The volatilization of volatile active material in Moschus processed.And dry 30-45 minutes cause the knot inside Moschus in 25-35 DEG C of environment
Brilliant water can directly be changed into vaporous water, further reduce the moisture in Moschus, extend the holding time of Moschus and can have
Effect slows down the volatilization of volatile ingredient in Moschus.
Further, the pressure that the first of freeze-drying is dried is 0.7-1Mpa, and second of the pressure dried is 3-6Mpa,
At this pressure, the solid water on Moschus surface and internal solid state crystallization water quickly and directly can be changed into gaseous state from solid-state,
And the volatile ingredient in Moschus will not be taken out of.
S4, Moschus is positioned over it is fresh-keeping in the sealing container with fresh-keeping gas；
First, in parts by weight, fresh-keeping gas aoxidizes including 70-80 parts nitrogen, 10-15 parts carbon dioxide, 5-10 parts one
Carbon and 10-12 part vaporous waters.The preparation of i.e. fresh-keeping gas is by 70-80 parts nitrogen, 10-15 parts carbon dioxide, 5-10 parts one
Carbonoxide and 10-12 part vaporous waters are mixed.Above-mentioned each gas carries out mixing using aforementioned proportion effectively to be prevented
Diaphragm is formed on Moschus surface with air-isolation, Moschus Deterioration can be effectively prevented and prevent the active component in Moschus
Scatter and disappear.
Wherein, carbon dioxide can effectively suppress the growth and breeding of the microorganisms such as bacterium in Moschus, mould, can play and slow down
The rotten effect of protein oxidation in Moschus.Water can play the protection indeformable effect of Moschus.Carbon monoxide has reproducibility
The anti-oxidation of energy, the effect that protein is not oxidized in protection Moschus is played, also there is certain color-protecting function.And nitrogen gas with
Each component effect gas, which cooperates, causes the holding time of Moschus significantly to extend.Preferably, carbon dioxide selects food-grade
Carbon dioxide.The enough diaphragms that formed on the surface of Moschus of nitrogen can effectively prevent Moschus Deterioration with air-isolation.And due to
Nitrogen is widely used in food service industry, and its security can more be received by consumers in general.Preferably, nitrogen selects food-grade nitrogen
Gas.
Specifically, it is that will freeze first freeze-drying Moschus to be positioned over fresh-keeping in the sealing container with fresh-keeping gas
Dried Moschus is positioned in sealing container, is then filled with nitrogen, carbon dioxide, carbon monoxide and vaporous water together one by one
In one sealing container, and pressure in sealed container is monitored to control the charge of each component gas during being filled with.Need
It is bright, by nitrogen, carbon dioxide, carbon monoxide and vaporous water be filled with one by one same nitrogen, carbon dioxide, carbon monoxide with
And in vaporous water be to be filled with one by one, each gas component, which has no, specific is filled with order.According to Dalton's law, fresh-keeping gas
Gross pressure is equal to each component partial pressure sum, therefore when each component gas is filled with sealing container by pressure in monitoring of containers to control
Gas charge processed causes each component gas to reach required proportioning.
Further, each component gas be filled with sealing container make sealing container reach close after setup pressure value it is close
Inlet valve of container is sealed, intake valve is opened after the pipeline for connecting sealing container is vacuumized again and is passed through the gas of next packet point.
Gas is passed through in sealing container after reaching setup pressure value and closes intake valve, now connected and also retained in the pipeline of sealing container
There is upper one to be filled with component gases, each composition proportion of fresh-keeping gas finally given for guarantee is accurate enough, and pipeline is vacuumized, taken out
Walk to open intake valve again after gas therein and be passed through next gas into sealing container.
It should be noted that when each component gas is filled with sealing container, it should be noted that the gas atmosphere being filled with should
Higher than the air pressure in sealing container, to prevent back flow of gas.Meanwhile gas should delay boost process when being filled with sealing container
Slow-motion row, with avoid because boost it is too fast caused by sealing container temperature change and the component that causes to finally give match it is inaccurate.
Further, after the fresh Moschus after freeze-drying is positioned in sealing container, the pressure in sealing container is outer
1.13-1.32 times of boundary's pressure.Pressure in sealing container is more than ambient pressure so that the gas in sealing container can be to close
Seal container and form extruding, while exclusion ability of the fresh-keeping gas to air can be strengthened, further prevent air and Moschus
Contact.And it can either ensure that air can not contact with Moschus using above-mentioned pressure and it also avoid hypertonia and cause to close
Seal the requirement of container.
The present invention also provides a kind of Moschus piece, and the Moschus piece is prepared by the preparation technology of above-mentioned Moschus.
The present invention forms one layer of preservative film by composite preservative on Moschus surface prevents air from being contacted with Moschus, prevents musk deer
Perfume is rotten, extends the holding time of Moschus.Preservative film can also reduce the volatilization of volatile active in Moschus, lifting simultaneously
The content of active component in Moschus.Then go the water for removing fresh Moschus surface and inside using freeze-drying, further subtract
Lack the volatilization of volatile ingredient in Moschus, while promoted the adhesive force of composite preservative and Moschus, further extend Moschus
Holding time.Then Moschus is positioned in the sealing container with fresh-keeping air, can further reduce Moschus and air
Matter exchange, further lifted Moschus in active component content.
Embodiment 1
A kind of preparation technology for Moschus that the present embodiment provides, comprises the following steps：
S1, prepare composite preservative；
By 60g chitosans, 100g water, 30g Tea Polyphenols, 5g vitamin Cs, 1g edible salts, 3g clove oils, 3g artemisia annua essential oils
Carry out being mixed to get composite preservative with 1g kamuning essential oil.
S2, fresh Moschus mix with composite preservative；
Fresh Moschus is positioned in composite preservative and carries out immersion 15 minutes.Composite preservative and fresh Moschus are mixed into
Row is ultrasonically treated.
S3, freeze-drying；
Moschus of the surface covered with preservative film is freeze-dried.Freeze-drying is that 3 points are freezed at a temperature of -30 DEG C
Clock, then respectively 0 DEG C, pressure be 0.7Mpa environment in dry 15 minutes, 25 DEG C, pressure be 3Mpa environment in dry 30
Minute.
S4, Moschus is positioned over it is fresh-keeping in the sealing container with fresh-keeping gas；
It is after being freeze-dried first that freeze-drying Moschus, which is positioned over fresh-keeping in the sealing container with fresh-keeping gas,
Moschus be positioned in sealing container, by 70g nitrogen, 10g carbon dioxide, 5g carbon monoxide and 10g vaporous waters one by one then
It is filled with same sealing container, finally, the pressure in sealing container is 1.13 times of ambient pressure.
The present invention also provides a kind of Moschus piece, and the Moschus piece is prepared by the preparation technology of above-mentioned Moschus.
Embodiment 2
A kind of preparation technology for Moschus that the present embodiment provides, comprises the following steps：
S1, prepare composite preservative；
By 80g chitosans, 120g water, 50g Tea Polyphenols, 10g vitamin Cs, 3g edible salts, 5g clove oils, 5g sweet wormwoods essence
Oil, 1g calcium chloride and 3g kamuning essential oil carry out being mixed to get composite preservative.
S2, fresh Moschus mix with composite preservative；
Fresh Moschus is positioned in composite preservative and carries out immersion 30 minutes.Composite preservative and fresh Moschus are mixed into
Row is ultrasonically treated.
S3, freeze-drying；
Moschus of the surface covered with preservative film is freeze-dried.Freeze-drying is that 5 points are freezed at a temperature of -20 DEG C
Clock, then respectively 5 DEG C, pressure be 1Mpa environment in dry 30 minutes, 35 DEG C, pressure be 6Mpa environment in dry 45 points
Clock.
S4, Moschus is positioned over it is fresh-keeping in the sealing container with fresh-keeping gas；
It is after being freeze-dried first that freeze-drying Moschus, which is positioned over fresh-keeping in the sealing container with fresh-keeping gas,
Moschus be positioned in sealing container, by 80g nitrogen, 15g carbon dioxide, 10g carbon monoxide and 12g vaporous waters one by one then
It is filled with same sealing container, finally, the pressure in sealing container is 1.32 times of ambient pressure.
The present invention also provides a kind of Moschus piece, and the Moschus piece is prepared by the preparation technology of above-mentioned Moschus.
Embodiment 3
A kind of preparation technology for Moschus that the present embodiment provides, comprises the following steps：
S1, prepare composite preservative；
By 70g chitosans, 110g water, 40g Tea Polyphenols, 7g vitamin Cs, 2g edible salts, 4g clove oils, 4g artemisia annua essential oils
Carry out being mixed to get composite preservative with 2g kamuning essential oil.
S2, fresh Moschus mix with composite preservative；
Fresh Moschus is positioned in composite preservative and carries out immersion 20 minutes.Composite preservative and fresh Moschus are mixed into
Row is ultrasonically treated.
S3, freeze-drying；
Moschus of the surface covered with preservative film is freeze-dried.Freeze-drying is that 3-5 is freezed at a temperature of -25 DEG C
Minute, then respectively 3 DEG C, pressure be 0.8Mpa environment in dry 20 minutes, 30 DEG C, pressure be 4Mpa environment in dry
40 minutes.
S4, Moschus is positioned over it is fresh-keeping in the sealing container with fresh-keeping gas；
It is after being freeze-dried first that freeze-drying Moschus, which is positioned over fresh-keeping in the sealing container with fresh-keeping gas,
Moschus be positioned in sealing container, by 75g nitrogen, 13g carbon dioxide, 8g carbon monoxide and 11g vaporous waters one by one then
It is filled with same sealing container, finally, the pressure in sealing container is 1.2 times of ambient pressure.
The present invention also provides a kind of Moschus piece, and the Moschus piece is prepared by the preparation technology of above-mentioned Moschus.
Embodiment 4
A kind of preparation technology for Moschus that the present embodiment provides, comprises the following steps：
S1, prepare composite preservative；
By 65g chitosans, 115g water, 45g Tea Polyphenols, 9g vitamin Cs, 2g edible salts, 3g clove oils, 5g sweet wormwoods essence
Oil, 1g calcium chloride and 1g kamuning essential oil carry out being mixed to get composite preservative.
S2, fresh Moschus mix with composite preservative；
Fresh Moschus is positioned in composite preservative and carries out immersion 20 minutes.Composite preservative and fresh Moschus are mixed into
Row is ultrasonically treated.
S3, freeze-drying；
Moschus of the surface covered with preservative film is freeze-dried.Freeze-drying is that 5 points are freezed at a temperature of -27 DEG C
Clock, then respectively 4 DEG C, pressure be 0.9Mpa environment in dry 27 minutes, 32 DEG C, pressure be 5Mpa environment in dry 42
Minute.
S4, Moschus is positioned over it is fresh-keeping in the sealing container with fresh-keeping gas；
It is after being freeze-dried first that freeze-drying Moschus, which is positioned over fresh-keeping in the sealing container with fresh-keeping gas,
Moschus be positioned in sealing container, by 73g nitrogen, 12g carbon dioxide, 6g carbon monoxide and 10g vaporous waters one by one then
It is filled with same sealing container, finally, the pressure in sealing container is 1.3 times of ambient pressure.
The present invention also provides a kind of Moschus piece, and the Moschus piece is prepared by the preparation technology of above-mentioned Moschus.
Experimental example
Routinely steam distillation is extracted in Moschus after Moschus obtained by embodiment 1-4 is placed 1 year under field conditions (factors)
Volatile active, and yield is charged into table 1.
Comparative example 1
Take with comparative example quality physicochemical property identical fresh musky, therein waved according to the extraction of the conventional steam way of distillation
Hair property active component, and yield is charged into table 1.
Comparative example 2
Take with experimental example same breed and place naturally dry in the shade after the Moschus of 1 year, extracted according to the conventional steam way of distillation
Volatile active therein, and yield is charged into table 1.
Comparative example 3
Take with experimental example same breed and place naturally dry in the shade after the Moschus of 3 years, extracted according to the conventional steam way of distillation
Volatile active therein, and yield is charged into table 1.
The yield of the volatile ingredient of the experimental example of table 1 and the Moschus of comparative example
It can be seen from the result of table 1, the Moschus that 1-4 of the embodiment of the present invention is provided extracts the content of obtained volatile ingredient
Higher than the Moschus that placed 3 years and 1 year, less than fresh Moschus, illustrate to contain in embodiment 1-4 Moschus and largely wave
Hair property active component, illustrates that the Moschus can be deposited for a long time, illustrates that the preparation technology can ensure the Moschus preserved for a long time
Interior volatile ingredient is not easy to volatilize out of Moschus, then ensures the drug effect of Moschus.
In summary, 1-4 of embodiment of the present invention preparation technology forms one layer of guarantor on Moschus surface using composite preservative
Fresh film prevents air from being contacted with Moschus, prevents Moschus from going bad, and extends the holding time of Moschus.Preservative film can also reduce musk deer simultaneously
The volatilization of volatile active in perfume (or spice), lift the content of active component in Moschus.Then go to remove using freeze-drying fresh
Moschus surface and inside water, further reduce the volatilization of volatile ingredient in Moschus, at the same promote composite preservative with
The adhesive force of Moschus, further extend the holding time of Moschus.Moschus then is positioned over into the sealing with fresh-keeping air to hold
In device, exchanging for Moschus and the matter of air can be further reduced, further lifts the content of active component in Moschus.
Embodiments described above is part of the embodiment of the present invention, rather than whole embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiment in the present invention, what those of ordinary skill in the art were obtained under the premise of creative work is not made
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
1. a kind of preparation technology of Moschus, it is characterised in that comprise the following steps:Fresh Moschus is mixed to get with composite preservative
Moschus of the surface covered with preservative film, it will be positioned over again with fresh-keeping after Moschus freeze-drying of the surface covered with preservative film
It is fresh-keeping in the sealing container of gas；
In parts by weight, the composite preservative includes 60-80 parts chitosan, 100-120 parts water, 30-50 parts Tea Polyphenols, 5-10
Part vitamin C, 1-3 parts edible salt, 3-5 parts clove oil, 3-5 parts artemisia annua essential oil and 1-3 part kamuning essential oils.
2. the preparation technology of Moschus according to claim 1, it is characterised in that the Moschus freeze-drying is in -30--
3-5 minutes are freezed at a temperature of 20 DEG C, 15-30 minutes are then dried in 0-5 DEG C of environment respectively, in 25-35 DEG C of environment
Dry 30-45 minutes.
3. the preparation technology of Moschus according to claim 1, it is characterised in that the composite preservative and the fresh Moschus
During mixing, to the mixture of the composite preservative and the fresh Moschus in be passed through ozone.
4. the preparation technology of Moschus according to claim 3, it is characterised in that the concentration of the ozone is 3-10ppm.
5. the preparation technology of Moschus according to claim 1, it is characterised in that the fresh Moschus and the composite preservative
The time of mixing is 15-30 minutes.
6. the preparation technology of Moschus according to claim 1, it is characterised in that to the composite preservative and the fresh musk deer
Fragrant mixing is ultrasonically treated.
7. the preparation technology of Moschus according to claim 1, it is characterised in that the composite preservative also includes 1-2 parts
Calcium chloride.
8. the preparation technology of Moschus according to claim 1, it is characterised in that in parts by weight, the fresh-keeping gas bag
Include 70-80 parts nitrogen, 10-15 parts carbon dioxide, 5-10 parts carbon monoxide and 10-12 part vaporous waters.
9. the preparation technology of Moschus according to claim 1, it is characterised in that put the fresh Moschus after freeze-drying
After being placed in the sealing container, the pressure in the sealing container is 1.13-1.32 times of ambient pressure.
A kind of 10. Moschus piece, it is characterised in that the system that the Moschus piece passes through the Moschus described in claim 1-9 any one
Standby technique is prepared.
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Cited By (1)
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| CN107536851B (en) | 2020-12-08 |
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Effective date of registration: 20230805 Address after: 452570 Yuanhang Road Power Plant Family Courtyard, Yuzhou City, Xuchang City, Henan Province Patentee after: Shi Shengxun Address before: 462000 industrial cluster of Luohe City, Henan Province Patentee before: HENAN SANHE PHARMACEUTICAL Co.,Ltd. |
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Effective date of registration: 20231109 Address after: 462600 Within Sanhe Pharmaceutical Institute, Industrial Cluster Zone, Linying County, Luohe City, Henan Province Patentee after: Henan Luming Musk Industry Breeding Co.,Ltd. Address before: 452570 Yuanhang Road Power Plant Family Courtyard, Yuzhou City, Xuchang City, Henan Province Patentee before: Shi Shengxun |