CN107536836A - The effect of beneficial liver and its application of 6 benayl aminopurines - Google Patents
The effect of beneficial liver and its application of 6 benayl aminopurines Download PDFInfo
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- CN107536836A CN107536836A CN201710886734.8A CN201710886734A CN107536836A CN 107536836 A CN107536836 A CN 107536836A CN 201710886734 A CN201710886734 A CN 201710886734A CN 107536836 A CN107536836 A CN 107536836A
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- hepatitis
- benzyl aminopurine
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses the purposes in purposes and treatment animal hepatitis of 6 benayl aminopurines in the medicine and beneficial liver health food for preparing treatment hepatitis.Medicine using 6 benayl aminopurines as active ingredient can effectively treat virus hepatitis and toxic hepatitis.
Description
Technical field
The present invention relates to a kind of purposes of compound in medicines and health protection, is prepared by 6-benzyl aminopurine specifically
Treat the application of hepatitis medicament, health food and animal benefit liver product.
Background technology
Among gastral disease, hepatopathy is to seriously endanger the disease of people's health.China there are about 100,000,000 B-type hepatitis at present
Malicious lifelong carrier and tens million of hepatitis patients, wherein 30,000,000 people can be transformed into chronic hepatitis, hepatic sclerosis, liver cancer, it is annual because
Hepatopathy and death people there are about hundreds of thousands of them.In recent years, with the continuous improvement of living standards of the people, by be addicted to drink with it is some other
Fatty liver caused by factor, also increases increasingly, accounts for 1/3 of population or so.While damage is caused to health, China is annual
Tens billion of yuans are reached for treating the costly of hepatopathy, very big influence is also result in national economy and social development.
Method due to still lacking specific treatment hepatitis at present, so the new drug of exploitation treatment hepatopathy is very urgent and important.Animal
Equally easily occur various hepatopathys, for example the virus hepatitis of duck is exactly to cause a kind of to fall ill of duckling by duck hepatitis virus
Acute exposure sexually transmitted disease anxious, propagation is fast, the death rate is high.
6-benzyl aminopurine is a kind of our newest compounds screened, there is no people to find medicinal after its vivo medicine-feeding
And health value.
The content of the invention
It is an object of the invention to provide the new application of 6-benzyl aminopurine, i.e., in the medicine for preparing treatment human hepatitis
New opplication in new opplication and animal hepatitis medicament.
It is a further object of the present invention to provide a kind of medicine for treating hepatitis.
Another object of the present invention is to provide a kind of health food for treating hepatitis.
Inventor according to《New drug preclinical study guideline》The hepatoprotective agent method pair of (1993, national Bureau of Drugs Supervision) etc.
6-benzyl aminopurine has carried out medical judgement research.
Inventor has found, is injected intraperitoneally and is administered orally with 6-benzyl aminopurine, there is obvious effect, serum life
Change functional parameter and hepatic pathology index all improves significantly.
When being treated with 6-benzyl aminopurine, it can be with pulvis, granula, tablet, capsule, pill and liquid preparation etc.
Form is administered orally；Can also in the form of parenteral solution, suppository, percutaneous preparation, inhalant etc. parenteral administration.6-benzyl aminopurine
Effective agent, be by with appropriate medicinal blend, such as excipient, adhesive, bleeding agent, lubricant mixing and prepare
Into.
Dosage changes with the state of an illness of patient, method of administration, the age of patient and body weight.In the situation of oral administration
Under, dosage is usually adult 20~100mg/kg/ days, preferably 10~50mg/kg/ days.
It is an advantage of the invention that：
6-benzyl aminopurine is the compound that can treat virus hepatitis and toxic hepatitis.
Hepatitis B is great virus hepatitis disease in China.Acting on for the anti-hepatitis B of 6-benzyl aminopurine is internal and international
On be all to find first.The anti-duck hepatitis B of 6-benzyl aminopurine is also all at home and in the world to find first.
6-benzyl aminopurine is the compound that can treat toxic hepatitis.The anti-toxic hepatitis of 6-benzyl aminopurine
Act on internal and international is also all to find first.
6-benzyl aminopurine is the compound that a kind of in the market has sale.
The english name of 6-benzyl aminopurine is：6-Benzylaminopurine
Chinese name：6-benzyl aminopurine.
Molecular formula：C12H11N5
Molecular weight：225.25
CAS registration numbers：1214-39-7
Other titles：BA；N6-Benzyladenine；N6-Benzyladenine。
Chemical constitution is：
6-benzyl aminopurine has promotion plant cell division, blade guarantor is green, prevent shedding and promotes Translocation of Assimilates etc. more
Kind effect, is agriculturally to apply wider plant growth regulating substance.During synthetically produced and use, Ren Men
The chance for taking in certain 6-benzyl aminopurine can be contacted during edible agricultural product, but there is presently no see the mankind by 6- benzyls
The report of adenine phosphate adverse reaction.
Embodiment
Examples provided below is used for that the present invention is furture elucidated, and is not meant to limit the scope of the invention.
1. material
6-benzyl aminopurine used in embodiment is bought by the market of chemical reagent.
Other medicines, reagent and experimental animal, easily it can buy from the market.
2. preparation method example
6-benzyl aminopurine 100g, hydroxyethyl cellulose 10g are taken, tabletting is made tablet, is placed in the vessel of air drying
It is standby.
3. test method
Experimental animal is adult healthy male CD-1 mouse or human hepatitis B virus transgenic mice.There is provided during experiment enough
Running water and normal diet.Mouse is grouped at random by body weight.It is to give for three days on end in being observed in the effect of toxic hepatitis
Medicine, once a day.Take within 4th day blood and leave and take animal's liver, determine liver function enzyme alanine transaminase (ALT) and second in serum
Hepatovirus surface antigen (HBsAg), observe hepatic pathology intensity of variation.Experimental data is represented with mean ± standard deviation.Using
The methods of EXCEL statistical softwares are examined to experimental result using variance analysis, t analyzes and processes, p<0.05 thinks that group difference has
There is conspicuousness.
Suppress duck hepatitis B virus experiment.Using an age in days Beijing duck, every group 6, intravenous injection duck hepatitis-B is sick
Poison, start after 7 days to duck positive control drug or 6-benzyl aminopurine treatment.It is administered orally 1 day 2 times, 10 days.Before administration
(T0), be administered after 5 days (T5), administration after 10 days (T10) and be discontinued after 3 days, weigh, observe animation, record death toll,
Judge that drug oral has nontoxicity.Taking blood system, measure non-toxic medicine is to duck serum duck hepatitis B virus DNA from serum
(DHBV-DNA) influence.
4. result of the test：
(1) effect (being shown in Table 1) of the anti-thioacetamide toxic hepatitis of 6-benzyl aminopurine.
The effect (Biochemical Indices In Serum) of the anti-thioacetamide toxic hepatitis of the 6-benzyl aminopurine of table 1
Compared with thioacetamide model group, * p ﹤ 0.05 (n=5)
(2) effect (being shown in Table 2) of the anti-paracetamol toxic hepatitis of 6-benzyl aminopurine.
The effect (Biochemical Indices In Serum) of the anti-paracetamol toxic hepatitis of the 6-benzyl aminopurine of table 2
Compared with paracetamol model group, * p ﹤ 0.05, * * p ﹤ 0.01 (n=5)
(3) effect (being shown in Table 3) of the anti-virus B hepatitis of 6-benzyl aminopurine
The effect (Biochemical Indices In Serum) of the anti-virus B hepatitis of the 6-benzyl aminopurine of table 3
Compared with hepatitis group, * p ﹤ 0.05, * * p ﹤ 0.01 (n=9)
(4) anti-duck hepatitis-B result
Description of test；6-benzyl aminopurine is opened 1 age in days duckling Intravenous Infection duck hepatitis B virus (DHBV) on the 7th day afterwards
Begin treatment, orally, 10 days 2 times a day, play the role of suppress duck serum DHBV-DNA, inhibitory action continue to drug withdrawal after 3 days.
Claims (5)
- A kind of 1. medicine for treating hepatitis, it is characterised in that：Contain 6-benzyl aminopurine.
- A kind of 2. beneficial liver health food, it is characterised in that：Contain 6-benzyl aminopurine.
- Application of the 3.6- benayl aminopurines in the medicine for preparing treatment virus hepatitis.
- Application of the 4.6- benayl aminopurines in the medicine for preparing treatment toxic hepatitis.
- Application of the 5.6- benayl aminopurines in the medicine for preparing treatment animal hepatitis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710886734.8A CN107536836A (en) | 2017-09-22 | 2017-09-22 | The effect of beneficial liver and its application of 6 benayl aminopurines |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710886734.8A CN107536836A (en) | 2017-09-22 | 2017-09-22 | The effect of beneficial liver and its application of 6 benayl aminopurines |
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| Publication Number | Publication Date |
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| CN107536836A true CN107536836A (en) | 2018-01-05 |
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| CN201710886734.8A Withdrawn CN107536836A (en) | 2017-09-22 | 2017-09-22 | The effect of beneficial liver and its application of 6 benayl aminopurines |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850072A (en) * | 2006-03-14 | 2006-10-25 | 北京大学 | Pharmaceutical use of alpha-(2,4-dichlorobenzyle)-1H-imidazole-1-ethanol for treating hepatitis |
| CN102670614A (en) * | 2012-01-04 | 2012-09-19 | 河南科技大学 | Application of compound 6-benzylaminopurine (BA) in preparation of composition for inhibiting oxidative damage of hepatic tissues |
| CN107158004A (en) * | 2017-05-11 | 2017-09-15 | 河南科技大学 | A kind of application of 6 benayl aminopurine |
-
2017
- 2017-09-22 CN CN201710886734.8A patent/CN107536836A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850072A (en) * | 2006-03-14 | 2006-10-25 | 北京大学 | Pharmaceutical use of alpha-(2,4-dichlorobenzyle)-1H-imidazole-1-ethanol for treating hepatitis |
| CN102670614A (en) * | 2012-01-04 | 2012-09-19 | 河南科技大学 | Application of compound 6-benzylaminopurine (BA) in preparation of composition for inhibiting oxidative damage of hepatic tissues |
| CN107158004A (en) * | 2017-05-11 | 2017-09-15 | 河南科技大学 | A kind of application of 6 benayl aminopurine |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180105 |