CN107519129A - A kind of ambroxol hydrochloride oral solution and preparation method thereof - Google Patents
A kind of ambroxol hydrochloride oral solution and preparation method thereof Download PDFInfo
- Publication number
- CN107519129A CN107519129A CN201710846759.5A CN201710846759A CN107519129A CN 107519129 A CN107519129 A CN 107519129A CN 201710846759 A CN201710846759 A CN 201710846759A CN 107519129 A CN107519129 A CN 107519129A
- Authority
- CN
- China
- Prior art keywords
- ambroxol hydrochloride
- preparation
- hydrochloride oral
- minutes
- oral solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Botany (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention is to provide a kind of ambroxol hydrochloride oral solution and preparation method thereof, contain in every 10000mL ambroxol hydrochloride oral solutions:Ambroxol hydrochloride 31g, the 20g of sodium hydrogensulfite 10, the 300g of sucrose 200, the 2500ml of honey 1500.The pH value of the ambroxol hydrochloride oral solution is 3.5 4.5.The present invention is by optimization formula, in the case where not adding preservative, pH adjusting agent, cosolvent and essence, realize it is stability-enhanced simultaneously, making mouthfeel, more preferably drug effect is stronger.The present invention chooses the honey rational proportion formula clinically to moisten the lung and relieve the cough, realizes super expected effect, avoids the addition of preservative, pH adjusting agent and cosolvent, this product is turned into the oral liquid more healthy to human body, improves core competitiveness.
Description
Technical field
The present invention relates to pharmaceutical technology field, is to be related to a kind of ambroxol hydrochloride oral solution and preparation method thereof.
Background technology
Ambroxol hydrochloride is metabolite of the bromhexine in human body, is that a kind of new glutinous phlegm dissolves medicine, German Bo Linge
Yin Gehan released in 1979.Listed successively in many countries such as France, Italy, Japan, Spain later.Present hydrochloric acid ammonia
Bromine rope turns into clinically acts on most strong expectorant, and clinic is extremely affirmed to its curative effect, and its toxic side effect also very little, hydrochloric acid
Ambroxol can shorten the treatment time of infection in respiratory system, reduce complication rate and case fatality rate, be applicable age broadness, can be wide
It is general to be used for various acute and chronic PUD Ds, ARDS, there is the work for reducing sputum viscosity, improving patient's expectoration function and PFT
With curative for effect, patient can generally be resistant to very well
Mucus hypersecretion is the important pathophysiological feature of chronic inflammatory airway disease, can aggravate respiratory tract air flow resistance
Plug, accelerates decline in pulmonary function, and the mucus of air flue retention also turns into the good culture medium of bacterial growth, the hair for causing air flue Inner to infect
Raw and exacerbation, and infection and follow-up inflammatory products further cause mucus hypersecretion, so as to form vicious circle, increase disease
Admission rate and case fatality rate.The viscoelasticity of airway mucus is mainly determined that ambroxol hydrochloride can decompose it by mucin therein
In saccharide portion, and increase the secretion of respiratory mucosa slurries body of gland, reduce mucus glandular secretion, so as to reduce sputum viscosity,
Promote mucus discharge, the synthesis to alveolar surfactant remarkably promotes effect with secretion, can increase bronchus cilium fortune
It is dynamic, play a part of notable expectoration, improve breath state.
Honey is described as in the Nature most perfect nutraceutical, can harmonizing the spleen and stomach;Relieving spasm to stop pain;Moisten the lung and relieve the cough;Ease constipation
Defaecation;Moisturizing myogenic;Removing toxic substances.The empty pain of main gastral cavity abdomen;Xeropulmonary cough;Dry constipation of intestines;Hot eyes;Aphtha;Unhealing ulcer;Rubella itch;
Scald;Brothers' (army's skin) are split.《Prescriptions worth thousand gold》In be used for control cough, pant, there is thing, spitting blood in larynx.Honey as flavouring,
Stabilizer, strengthen the effect of drug effect with collaboration.Honey rational proportion formula, realizes super expected effect, avoids anti-
The addition of rotten agent, pH adjusting agent and cosolvent, this product is turned into the ambroxol hydrochloride oral solution more healthy to human body, there is core
Heart competitiveness.
For ambroxol hydrochloride as oral administration solution, technique is simple, and cost is low, convenient to take, particularly suitable for the elderly and children,
Medicine is scattered in medium with molecular forms, and decentralization is big, absorbs fast, the relatively rapid performance curative effect of energy, raising bioavilability.
But in existing ambroxol hydrochloride oral solution, preservative, cosolvent, pH adjusting agent, essence etc. are mostly added, in treatment
The material factor unfavorable to body is have also been introduced simultaneously, mouthfeel is also poor, and patient medication biddability is not naturally high.
The content of the invention
The defects of in order to overcome ambroxol hydrochloride oral solution prior art, the invention provides a kind of salt being completely newly formulated
Sour ambroxol oral liquid, preservative, pH adjusting agent are avoided, the addition of cosolvent and essence, this product is turned into human body more
The ambroxol hydrochloride oral solution of health, patient take compliance height.
The invention provides a kind of compound method of ambroxol hydrochloride oral solution, this method technique simple possible, saves,
Key factor is controllable, and the product stability of production is high.
Contain in per 10000mL ambroxol hydrochloride oral solutions:Ambroxol hydrochloride 31g, sodium hydrogensulfite 10-20g, sucrose
200-300g, honey 1500-2500ml, the pH value of oral administration solution are controlled in 3.5-4.5;The sodium hydrogensulfite is anti-oxidant
Agent, sucrose are flavouring, and honey strengthens the effect of drug effect with collaboration as flavouring, stabilizer.
Step is as follows:
(1) the sodium hydrogensulfite of recipe quantity is dissolved in 8-12 times of purified water of its weight (55~65 DEG C), it is standby.
(2) the ambroxol hydrochloride of recipe quantity is dissolved in 25-35 times of purified water of its weight (45~55 DEG C), it is standby.
(3) the purified water for volume 25%~50% of about making up a prescription is heated to boiling, adds the sucrose of recipe quantity, boil 15~20
Minute to being completely dissolved.It is cooled to 45~55 DEG C, adds the solution of sodium bisulfite dissolved in advance, stir 15~20 minutes, most
The ambroxol hydrochloride solution dissolved in advance and honey are added afterwards, and stir about filters for 15~20 minutes to whole dissolvings.(the mistake
Filter as one or both of 0.1-1 μm of miillpore filter, 0.1-1 μm of stud, clarification plate, 0.1-1 μm of clay rod combination of the above).
(4) purified water is added in the concentrated wiring liquid after (3) filtering, and is settled to recipe quantity, circulation stirring 30 minutes, sampling and measuring contains
Amount, pH (3.5-4.5), relative density (1.090-1.200), clarity, qualified rear decoction carry out refined filtration, medicine with hyperfiltration technique
Liquid embedding, sterilizing.
With reference to instantiation, the present invention is described in further detail:
Embodiment 1:Contain in per 10000mL ambroxol hydrochloride oral solutions:Ambroxol hydrochloride 31g, sodium hydrogensulfite
10g, sucrose 200g, honey 1500ml;
Step is as follows:
(1) the sodium hydrogensulfite of recipe quantity is dissolved in 8 times of purified waters of its weight (55 DEG C), it is standby.
(2) the ambroxol hydrochloride of recipe quantity is dissolved in 25 times of purified waters of its weight (45 DEG C), it is standby.
(3) the purified water for volume 25% of about making up a prescription is heated to boiling, adds the sucrose of recipe quantity, boil 15 minutes to complete
Dissolving.45 DEG C are cooled to, adds the solution of sodium bisulfite dissolved in advance, stirs 15 minutes, is eventually adding the salt dissolved in advance
Sour ambroxol solution and honey, stir about 15 minutes to whole dissolvings, 1 μm of stud, 0.1 μm of filtering with microporous membrane.
(4) purified water is added in the concentrated wiring liquid after (3) filtering, and is settled to recipe quantity, circulation stirring 30 minutes, sampling and measuring contains
Amount, pH (3.5-4.5), relative density (1.090-1.200), clarity, qualified rear decoction carry out refined filtration, medicine with hyperfiltration technique
Liquid embedding, sterilizing.
Embodiment 2:Contain in per 10000mL ambroxol hydrochloride oral solutions:Ambroxol hydrochloride 31g, sodium hydrogensulfite
20g, sucrose 300g, honey 2500ml;
Step is as follows:
(1) the sodium hydrogensulfite of recipe quantity is dissolved in about 12 times of purified waters of its weight (65 DEG C), it is standby.
(2) the ambroxol hydrochloride of recipe quantity is dissolved in about 35 times of purified waters of its weight (55 DEG C), it is standby.
(3) the purified water for volume 50% of about making up a prescription is heated to boiling, adds the sucrose of recipe quantity, boil 20 minutes to complete
Dissolving.55 DEG C are cooled to, adds the solution of sodium bisulfite dissolved in advance, stirs 20 minutes, is eventually adding the salt dissolved in advance
Sour ambroxol solution and honey, stir about 20 minutes to whole dissolvings, 1 μm of stud, 0.22 μm of filtering with microporous membrane.
(4) purified water is added in the concentrated wiring liquid after (3) filtering, and is settled to recipe quantity, circulation stirring 30 minutes, sampling and measuring contains
Amount, pH (3.5-4.5), relative density (1.090-1.200), clarity, qualified rear decoction carry out refined filtration, medicine with hyperfiltration technique
Liquid embedding, sterilizing.
Embodiment 3:Contain in per 10000mL ambroxol hydrochloride oral solutions:Ambroxol hydrochloride 31g, sodium hydrogensulfite
15g, sucrose 250g, honey 2000ml;
Step is as follows:
(1) the sodium hydrogensulfite of recipe quantity is dissolved in 10 times of purified waters of its weight (60 DEG C), it is standby.
(2) the ambroxol hydrochloride of recipe quantity is dissolved in 30 times of purified waters of its weight (50 DEG C), it is standby.
(3) the purified water for volume 40% of about making up a prescription is heated to boiling, adds the sucrose of recipe quantity, boil 18 minutes to complete
Dissolving.50 DEG C are cooled to, adds the solution of sodium bisulfite dissolved in advance, stirs 18 minutes, is eventually adding the salt dissolved in advance
Sour ambroxol solution and honey, stir about 1 μm of stud, clarify plate, 0.1 μm of filtering with microporous membrane in 17 minutes to whole dissolvings.
(4) purified water is added in the concentrated wiring liquid after (3) filtering, and is settled to recipe quantity, circulation stirring 30 minutes, sampling and measuring contains
Amount, pH (3.5-4.5), relative density (1.090-1.200), clarity, qualified rear decoction carry out refined filtration, medicine with hyperfiltration technique
Liquid embedding, sterilizing.
Embodiment 4:Contain in per 10000mL ambroxol hydrochloride oral solutions:Ambroxol hydrochloride 31g, sodium hydrogensulfite
20g, sucrose 200g, honey 1500ml;
Step is as follows:
(1) the sodium hydrogensulfite of recipe quantity is dissolved in 12 times of purified waters of its weight (65 DEG C), it is standby.
(2) the ambroxol hydrochloride of recipe quantity is dissolved in 35 times of purified waters of its weight (55 DEG C), it is standby.
(3) the purified water for volume 50% of about making up a prescription is heated to boiling, adds the sucrose of recipe quantity, boil 20 minutes to complete
Dissolving.55 DEG C are cooled to, adds the solution of sodium bisulfite dissolved in advance, stirs 20 minutes, is eventually adding the salt dissolved in advance
Sour ambroxol solution and honey, stir about 20 minutes to whole dissolvings, 1 μm of clay rod, 0.22 μm of filtering with microporous membrane.
(4) purified water is added in the concentrated wiring liquid after (3) filtering, and is settled to recipe quantity, circulation stirring 30 minutes, sampling and measuring contains
Amount, pH (3.5-4.5), relative density (1.090-1.200), clarity, qualified rear decoction carry out refined filtration, medicine with hyperfiltration technique
Liquid embedding, sterilizing.
Embodiment 5:Contain in per 10000mL ambroxol hydrochloride oral solutions:Ambroxol hydrochloride 31g, sodium hydrogensulfite 10,
Sucrose 250, honey 2000ml;
The compound method of above-mentioned ambroxol hydrochloride oral solution, the preparation method comprise the following steps:
(1) the sodium hydrogensulfite of recipe quantity is dissolved in 8 times of purified waters of its weight (55 DEG C), it is standby.
(2) the ambroxol hydrochloride of recipe quantity is dissolved in 25 times of purified waters of its weight (45 DEG C), it is standby.
(3) the purified water for volume 25% of about making up a prescription is heated to boiling, adds the sucrose of recipe quantity, boil 15 minutes to complete
Dissolving.45 DEG C are cooled to, adds the solution of sodium bisulfite dissolved in advance, stirs 15 minutes, is eventually adding the salt dissolved in advance
Sour ambroxol solution and honey, stir about clarify plate, the filtering of 1um studs in 15 minutes to whole dissolvings.
(4) purified water is added in the concentrated wiring liquid after (3) filtering, and is settled to recipe quantity, circulation stirring 30 minutes, sampling and measuring contains
Amount, pH (3.5-4.5), relative density (1.090-1.200), clarity, qualified rear decoction carry out refined filtration, medicine with hyperfiltration technique
Liquid embedding, sterilizing.
For above example, pilot scale sample preparation has been carried out respectively, and ambroxol hydrochloride oral solution is carried out respectively
Quality testing.Testing result such as following table:
Detection project | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
Content (mg/10ml) | 30.4 | 30.2 | 30.1 | 30.3 | 30.5 |
Character | Colorless clear liquid | Colorless clear liquid | Colorless clear liquid | Colorless clear liquid | Colorless clear liquid |
pH | 4.1 | 3.8 | 4.0 | 3.7 | 3.9 |
Relative density | 1.098 | 1.156 | 1.103 | 1.162 | 1.137 |
Impurity A (%) | 0.016 | 0.023 | 0.018 | 0.022 | 0.021 |
Other impurities (%) | 0.015 | 0.015 | 0.015 | 0.016 | 0.014 |
Total impurities (%) | 0.031 | 0.038 | 0.033 | 0.038 | 0.035 |
Any one has carried out clinical experimental study in selection above example, as a result as follows:
Cough, expectoration are its common clinical symptoms in respiratory disease, to the not smooth respiratory disease of expectoration
, cough therapeutic effect.
Method:Glue and be not easy using the cough caused by the various acute and chronic respiratory systems of ambroxol hydrochloride oral solution treatment, phlegm
120 patients of expectoration patient, are randomly divided into ambroxol hydrochloride group and bisolvon group.To improve patient's cough, expectoration easy degree
And amount of expectoration is index.
As a result:
1. to the effective percentage of expectoration easy degree and amount of expectoration
To the effective percentage of expectoration easy degree and amount of expectoration in ambroxol group 60:Effective 38, effective 21, invalid 1,
Total effective rate is 98.3%;To the effective percentage of expectoration easy degree and amount of expectoration in bisolvon group 60, wherein effective 22, effectively
25, invalid 13, total effective rate 78.3%, ambroxol group total effective rate is apparently higher than bisolvon group (P<0.05)
2. control rate and obvious effective rate are faced to cough:
Ambroxol hydrochloride oral solution is respectively 31.0% and 40.2% to face the control rate and obvious effective rate of cough, hence it is evident that is higher than
Bisolvon (being respectively 10.8% and 18.7%) (P<0.05).
Ambroxol hydrochloride oral solution of the present invention is a kind of highly effective eliminating the phlegm, cough suppressing medicine.
Results of stability:
(1) influence factor is tested
1. illumination factor
2. temperature 60 C
(2) low temperature freezing and thawing test:
Low-temperature circulating is tested:Circulation three times, is placed 2 days under the conditions of circulating in 4 DEG C every time, is then transferred to 40 DEG C of condition decentralizations
Put 2 days, detected.
Freeze-thaw cycle experiment:Circulation three times, is placed 2 days at -10 DEG C~-20 DEG C every time, is then transferred to 40 DEG C of condition decentralizations
Put 2 days, detected.
(3) accelerated test
(4) long term test
Stability test conclusion:Tested by series of stable, as a result prove that the ambroxol hydrochloride oral of the present invention is molten
Liquid has good stability.
Claims (6)
1. a kind of ambroxol hydrochloride oral solution and preparation method thereof, it is characterized in that:Per 10000mL ambroxol hydrochloride oral solutions
In contain:Ambroxol hydrochloride 31g, sodium hydrogensulfite 10-20g, sucrose 200-300g, honey 1500-2500ml, oral administration solution
PH value is controlled in 3.5-4.5;The sodium hydrogensulfite is antioxidant, and sucrose is flavouring, honey as flavouring, stably
Agent, strengthen the effect of drug effect with collaboration.
A kind of 2. ambroxol hydrochloride oral solution according to claim 1 and preparation method thereof, it is characterised in that:
2.1 are dissolved in the sodium hydrogensulfite of recipe quantity in 8-12 times of purified water of its weight, standby;
2.2 are dissolved in the ambroxol hydrochloride of recipe quantity in 25-35 times of purified water of its weight, standby;
The purified water for volume 25%~50% of about making up a prescription is heated to boiling by 2.3, adds the sucrose of recipe quantity, is boiled 15~20 minutes
To being completely dissolved.45~55 DEG C are cooled to, adds 2.1 solution dissolved in advance, is stirred 15~20 minutes, is eventually adding molten in advance
2.2 solution and honey of solution, stir about filter for 15~20 minutes to whole dissolvings;
2.4 purified waters are added in the concentrated wiring liquid after 2.3 filterings, are settled to recipe quantity, circulation stirring 30 minutes, sampling and measuring contains
Amount, pH, relative density, clarity, qualified rear decoction carry out refined filtration, embedding, sterilizing with hyperfiltration technique.
3. a kind of ambroxol hydrochloride oral solution according to claim 2.1 and preparation method thereof, it is characterized in that:Purified water
Temperature is 55~65 DEG C.
4. a kind of ambroxol hydrochloride oral solution according to claim 2.2 and preparation method thereof, it is characterized in that:Purified water
Temperature is 45~55 DEG C.
5. a kind of ambroxol hydrochloride oral solution according to claim 2.3 and preparation method thereof, it is characterized in that:The mistake
Filter as one or both of 0.1-1 μm of miillpore filter, 0.1-1 μm of stud, clarification plate, 0.1-1 μm of clay rod and combination of the above.
6. a kind of ambroxol hydrochloride oral solution according to claim 2.4 and preparation method thereof, it is characterized in that:PH value control
System is in 3.5-4.5;Relative density is 1.090-1.200.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710846759.5A CN107519129A (en) | 2017-09-19 | 2017-09-19 | A kind of ambroxol hydrochloride oral solution and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710846759.5A CN107519129A (en) | 2017-09-19 | 2017-09-19 | A kind of ambroxol hydrochloride oral solution and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN107519129A true CN107519129A (en) | 2017-12-29 |
Family
ID=60736069
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710846759.5A Pending CN107519129A (en) | 2017-09-19 | 2017-09-19 | A kind of ambroxol hydrochloride oral solution and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN107519129A (en) |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1628647A (en) * | 2004-10-11 | 2005-06-22 | 成都拜特尔药业有限公司 | Ambroxol hydrochloride granule |
CN1836654A (en) * | 2005-03-25 | 2006-09-27 | 天津药物研究院 | Pharmaceutical composition for stabilizing ambroxol hydrochloride granula |
CN101352417A (en) * | 2008-08-29 | 2009-01-28 | 扬州市三药制药有限公司 | Ambroxol hydrochloride oral solution and preparation method thereof |
CN101961307A (en) * | 2010-09-14 | 2011-02-02 | 武汉人福药业有限责任公司 | Oral liquid for treating respiratory disease and preparation method thereof |
CN102309442A (en) * | 2010-07-07 | 2012-01-11 | 澳美制药厂 | Ambroxol hydrochloride oral aqueous composition and preparation method thereof |
CN104027326A (en) * | 2013-03-04 | 2014-09-10 | 天津康鸿医药科技发展有限公司 | Ambroxol hydrochloride atomization inhalant, and preparation method and application thereof |
CN105055385A (en) * | 2015-08-19 | 2015-11-18 | 上海华源安徽锦辉制药有限公司 | Composition injection containing ambroxol hydrochloride compound and preparation method thereof |
-
2017
- 2017-09-19 CN CN201710846759.5A patent/CN107519129A/en active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1628647A (en) * | 2004-10-11 | 2005-06-22 | 成都拜特尔药业有限公司 | Ambroxol hydrochloride granule |
CN1836654A (en) * | 2005-03-25 | 2006-09-27 | 天津药物研究院 | Pharmaceutical composition for stabilizing ambroxol hydrochloride granula |
CN101352417A (en) * | 2008-08-29 | 2009-01-28 | 扬州市三药制药有限公司 | Ambroxol hydrochloride oral solution and preparation method thereof |
CN102309442A (en) * | 2010-07-07 | 2012-01-11 | 澳美制药厂 | Ambroxol hydrochloride oral aqueous composition and preparation method thereof |
CN101961307A (en) * | 2010-09-14 | 2011-02-02 | 武汉人福药业有限责任公司 | Oral liquid for treating respiratory disease and preparation method thereof |
CN104027326A (en) * | 2013-03-04 | 2014-09-10 | 天津康鸿医药科技发展有限公司 | Ambroxol hydrochloride atomization inhalant, and preparation method and application thereof |
CN105055385A (en) * | 2015-08-19 | 2015-11-18 | 上海华源安徽锦辉制药有限公司 | Composition injection containing ambroxol hydrochloride compound and preparation method thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101244193A (en) | Traditional Chinese medicine for treating respiratory disease and method for preparing the same | |
CN105125566B (en) | The application of mannoglucan aldehydic acid oligosaccharides and derivative in treatment and/or prevention nephrosis medicine or health products is prepared | |
CN114558049B (en) | Traditional Chinese medicine prescription for treating chronic obstructive pulmonary disease in stationary phase series and application thereof | |
CN107519129A (en) | A kind of ambroxol hydrochloride oral solution and preparation method thereof | |
CN108498568A (en) | Chinese patent drug, medical food and the preparation method of autoimmune and immune related diseases are treated with Goat Placenta or embryo | |
CN109045196B (en) | A composition for clearing lung-heat and eliminating phlegm and its preparation method | |
CN106389596A (en) | Medicine for treating pulmonary fibrosis | |
CN105770695A (en) | Application of membrane-source-opening beverage in preparation of acute lung injury resisting medicine | |
CN105902912A (en) | Medicine composition for treating infantile pneumonia | |
CN114209781B (en) | Traditional Chinese medicine composition for treating asthma | |
CN105147623A (en) | Oral lactulose lyophilized powder and preparation method thereof | |
CN108785559A (en) | A kind of drug and preparation method thereof for treating respiratory tract infection | |
CN104740428B (en) | A kind of compound tonifying blood containing red skin of peanut pharmaceutical preparation and its application and detection method | |
CN104147353B (en) | It is a kind of to treat morning, the Chinese medicinal enema of mid-term chronic renal failure | |
CN116999492A (en) | Medicinal liquor for treating gouty arthritis | |
CN105194635A (en) | Traditional Chinese medicine composition for navel therapy for treating child diarrhoea and preparation method of traditional Chinese medicine composition | |
CN1634340A (en) | Medicinal composition for preventing and treating children respiratory system diseases and preparation method thereof | |
CN106138594A (en) | A kind of Chinese medicine composition preventing and treating Hormone factor | |
CN111759895A (en) | A pharmaceutical composition for treating rhinitis, sinusitis and pharyngolaryngitis caused by wind-heat | |
CN110025722A (en) | The Chinese medicine composition and preparation method thereof for treating respiratory tract infection | |
CN104922567B (en) | It mends gold plaque and is preparing the application in treating diabetes medicament | |
CN105194545B (en) | A kind of Chinese medicine composition for treating asthma | |
CN118078867A (en) | Inonotus obliquus extraction composition for eliminating nodules and improving immunity and preparation method thereof | |
CN104042704B (en) | A kind of Traditional Chinese medicine permeation pump sheet for the treatment of diabetes | |
CN111803584A (en) | Traditional Chinese medicine compound preparation for treating acute exacerbation of idiopathic pulmonary interstitial fibrosis and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171229 |
|
RJ01 | Rejection of invention patent application after publication |