CN107513165A - A kind of high intensity adhesive double hydrogel and preparation method - Google Patents
A kind of high intensity adhesive double hydrogel and preparation method Download PDFInfo
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- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
- C08F220/56—Acrylamide; Methacrylamide
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F251/00—Macromolecular compounds obtained by polymerising monomers on to polysaccharides or derivatives thereof
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- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F289/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds not provided for in groups C08F251/00 - C08F287/00
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- C08J2333/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers
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- C08J2333/26—Homopolymers or copolymers of acrylamide or methacrylamide
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- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2351/00—Characterised by the use of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives of such polymers
- C08J2351/02—Characterised by the use of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives of such polymers grafted on to polysaccharides
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- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2405/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2401/00 or C08J2403/00
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2451/00—Characterised by the use of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives of such polymers
- C08J2451/02—Characterised by the use of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives of such polymers grafted on to polysaccharides
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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- C08J2489/00—Characterised by the use of proteins; Derivatives thereof
Abstract
The present invention designs a kind of high intensity and adhesive double hydrogel and preparation method thereof；Its preparation method is, basalis, which is formed, using radical polymerization forms tough hydrogel, treat that radical reaction is not up to complete, cohesive hydrogel is added on tough layer, continue with radical reaction, so that upper strata cohesive hydrogel is combined with the tough hydrogel that lower floor does not react completely so as to form high intensity adhesive double hydrogel, this method has been proved to have good associativity, and obvious layer structure can't occur in this double-deck hydrogel.This method is easy and effective, by toughness and the application field for being adhesively bonded to together, widen hydrogel.Mechanical property test display, this mechanical strength for gluing tough hydrogel reach 1.3 MPa, and most of applications can also be met by peeling off force intensity.
Description
Technical field
The present invention relates to one kind physical crosslinking and adhesive double hydrogel.
Background technology
Hydrogel is the high polymer material with cross-linked network synthesized using hydrophilic monomer as main monomer, can be absorbed
Substantial amounts of water.Hydrogel properties are soft, similar to vital tissues material, have good biocompatibility, therefore extensively should
, such as can be as tissue filling agent, medicinal slow release agent, the embedding of enzyme, protein electricity for fields such as biological medicine, organizational projects
Swimming, contact lenses, artificial blood plasma, artificial skin, tissue engineering bracket material etc..Existing most of researchs, are concentrated mainly on
The property Quality Research such as hydrogel toughness reinforcing and biocompatibility, the research on cohesive hydrogel are related to simultaneously few.And in China,
The research work of hydrogel is started late, and manufacturing enterprise is less, and the technical merit and application level of hydrogel material lag behind
American-European and Japan, because hydrogel also enough could not be solved effectively the problem of some require the application field of high-strength mechanical properties
Certainly, this also results in its application and is limited by very large.The feature of hydrogel is even more underexploitation, causes substantial amounts of technology
Rest in a small number of developed countries such as America and Europe.Therefore, invention is a kind of prepares the hydrogel with adhesive characteristics function with important meaning
Justice.
Although our existing hydrogels are with its unique application market, due to its soft material property so that water
Gel is restricted in the application for much requiring mechanical property field, with the development of hydrogel toughness reinforcing in recent years, water-setting
The mechanical strength of glue has obtained very big development, such as double-network hydrogel, microballoon toughness reinforcing hydrogel, slip ring hydrogel, topology
Hydrogel etc., these systems cause the mechanical strength of hydrogel or even can reach double nets of MPa grades, Gong Jianping et al. invention
Network hydrogel, the mechanical strength of the hydrogel made have reached 2MPa.（Suekama T C, Hu J, Kurokawa T, et
al. Double-network strategy improves fracture properties of chondroitin
sulfate networks[J]. ACS Macro Letters, 2013, 2(2): 137-140）.And nearest Oguz Okay
Et al. be prepared for a kind of hydrophobic cross-linker hydrogel with good self-healing performance, provided for the recycling of hydrogel material
Method（Can V, Kochovski Z, Reiter V, et al. Nanostructural evolution and self-
healing mechanism of micellar hydrogels[J]. Macromolecules, 2016, 49(6):
2281-2287.）.With the research of toughness reinforcing, J. Vlassak people are entered by multiple physical action to the mechanical property of hydrogel
Enhancing is gone（Jeon I, Cui J, Illeperuma W R K, et al. Extremely Stretchable and
Fast Self‐Healing Hydrogels[J]. Advanced Materials, 2016, 28(23): 4678-
4683.）.The method of these these increase energy dissipations causes the mechanical property of hydrogel to get a promotion, and has preferably application
Prospect..Although the lifting of mechanical strength makes hydrogel disclosure satisfy that some requirements applied, some functional hydrogels
Exploitation can not meet the market demand, particularly in the development process of cohesive hydrogel, it has been found that viscous to be often with tough
One relative property, cohesive hydrogel has good ductility, but the mechanical strength in application process becomes it
The shortcomings that fatal, although and toughness hydrogel does not have viscosity substantially with good mechanical strength, toughness hydrogel.To sum up
Described, the weak mechanical property of cohesive hydrogel and the single-function of toughness hydrogel are all mutual scarce as them are limited
Point, but simultaneously they the advantages of can supply it is mutual apply shortcoming, so preparing a kind of double-deck has bilayer-forming water-setting
Glue just becomes a significant research invention.
The present invention realizes the compound of double-deck hydrogel, and describes a kind of brand-new preparation method..Wherein hypothallus
Using a kind of tough hydrogel, and functional layer uses a kind of cohesive hydrogel, and two layers due to different structure two kinds of differences of imparting
Unique function.Double-deck hydrogel prepared by this method, obvious boundary line is had no at the connecing layer of two kinds of hydrogels, and to gel
Overall mechanical properties have no influence, i.e., two gels, which are in, is completely independent state, but is again one special overall.It is this
Method causes hydrogel not only to have the mechanical property of MPa ranks, and the viscosity also made has reached the requirement in real use.It is viscous
Tough hydrogel can have a good cementitiousness to different base materials, wherein base material include plastics, rubber, glass, metal with
And human body skin all has very strong cohesive force.
Tough layer can use any main monomer that can turn into hydrogel, such as acrylamide, hyaluronic acid, polyethylene
The materials such as alcohol, sodium alginate, using the physical crosslinking effect of hydrophobic aggregation or other physical actions, any chemical crosslinking is not added
Agent, make it have the good transparency and biocompatibility.And top viscous layer, we uses natural polysaccharide and acrylamide
Hydrogen bond action plastic, not only remain its transparent property, more cause tack coat there is good bonding for many base materials
Property.
The polymerization of the present invention uses radical polymerization, in special mould, is initially formed hypothallus, makes it have good
Good toughness, is triggered, and when basalis is at the eve of plastic, adds the viscous layer being already prepared on the base layer, together
It is added in special mould, makes together to react plastic in mould two layers, question response is complete, and gel is taken out, to viscous layer
Carry out PH processing so that viscous layer has good viscosity, and so, a kind of double-deck hydrogel is just made.
The content of the invention
The purpose of the present invention is to prepare a kind of hydrogel for having viscosity and toughness concurrently, there is provided one kind can be compound for preparing
The method of double-deck hydrogel, the double-deck hydrogel properties of preparation are stable, are a kind of with more preferable mechanical strength and right
Unique hydrogel of the cohesive force of different substrates.The application of mechanical property either repeatedly, or followed continuously multiple
In ring drawing process, double-deck hydrogel all has stable mechanical property, possesses good fatigue resistance.Moreover, on viscous
Property performance can also carry out Reusability, even if after multiple uses, viscous layer viscosity can't be with access times
Increase and decline excessively, there is good being applied multiple times property.More allow people excited, viscous layer also has good pharmaceutical carrier
Effect, what is used due to viscous layer of the present invention is natural polysaccharide mostly, and medicine used in us is pharmaceutical grade, to the phase of human body
Capacitive is very good, and by taking gum arabic as an example, gum arabic not only has good emulsification, meanwhile, it is also a kind of
Natural polysaccharide with bactericide, this causes nontoxic and sterilization effect to be achieved, due to the swelling behavior of hydrogel, I
Can also make wherein to be swelled some in network by the use of viscous layer as a kind of carrier layer of medicine and have medicative medicines
Thing so that double-deck hydrogel not only has good mechanical property, can also meet medical load request.
The invention provides a kind of method for preparing double-deck hydrogel, wherein its hypothallus of double-deck hydrogel is single by first
Body, surfactant, hydrophobic segment, sodium chloride, deionized water composition, viscous layer is by second comonomer, gum arabic, deionization
Water, light trigger composition.
Further, high intensity layer is drawn by surfactant, hydrophobic monomer, sodium chloride, the first monomer, deionized water, light
Agent composition is sent out, its composition is 2-4 parts；1-4 parts；0.5-1 parts；15-20 parts；70-80,0.5-1 part form.
Further, all analyses of medicine used in building-up process are pure.
Further, Arabic gum used is pharmaceutical grade in building-up process.
The preparation method of described double-deck hydrogel：
（a）Measure 70-80 part deionized waters to be put into in churned mechanically 150ml beakers A, separately weigh 0.5-1 part sodium chloride
It is put into container A, weighs 2-4 part surfactants and be put into container A, after solid dissolving, then 1-4 part hydrophobic monomers are added
Enter into the mixed liquor of container A, after the solution in container is transparent, then take the monomer of 15-20 parts first to add in mixed liquor, when the
After the dissolving of one monomer, 1 part of initiator is added.Take 5ml mixed liquors to be put into special mould C and carry out light-initiated, initiation light intensity
For 50%, trigger time 20min.
（b）Measure 70 parts of deionized waters to be put into in churned mechanically container B, add 5 parts of emulsifying agents or the breast of compounding
Agent, after solid dissolving, 5 parts of hydrophobic monomers are added, after stirring 2h, then 19 parts of second comonomer is added into container B, stirring
After 20min, 1 part of light trigger is added.The mixed liquid B that will be made, it is added in the mould C of plastic, again in light-initiated bar
It polymerize under part, wherein, light-initiated intensity is 50%, and the initiation time is 20min, and reaction is completed to can obtain composite double layer hydrogel.
（c）After water-setting to be composite composes, hydrogel is taken out into mould, PH modifications are carried out to viscous layer, adjust viscous layer
PH to 4.0-6.0 or so, you can make it have good viscosity, so, the hydrogel with double-deck property has just been produced
Cheng Liao.
Above-mentioned first monomer be acrylamide, hyaluronic acid, polyvinyl alcohol, acrylic acid and its salt, methacrylic acid and its
Combination more than one or both of salt, polyethyleneglycol diacrylate；
Above-mentioned second comonomer is gum arabic, agar, agarose, gelatin, collagen, fibrin, alginate, transparent
One or both of matter hydrochlorate, chondroitin sulfate, carragheen, gellan gum, guar gum, sesbania gum, chitosan, oxidized starch
Combination above；
Above-mentioned surfactant includes：Lauryl sodium sulfate, hexadecyltrimethylammonium chloride, DBSA
The one or two kinds of combinations therein of sodium, tween, sapn, gum arabic；
Above-mentioned initiator is 2- hydroxy-2-methyl -1- phenyl ketones（PI 1173）, 2- hydroxyls -4- (2- hydroxy ethoxies) -2- first
One kind in base propiophenone；
Above-mentioned initiation method is light-initiated, and light-initiated intensity is 50%, and the initiation time is 20min；
For the pH value of the gel between 4.0-6.0, microbiological indicator meets medical preparation requirement；
The plural gel has good stability, and has heat resistance and cold resistance, places it in and measures 40 in qualified constant incubator
± 1 DEG C, observed after keeping 24h；Place it in and measure in qualified cold storage refrigerator-5-10 DEG C, observed after keeping 24h；The above two
Observation and no significant difference before and after experiment in the case of kind.
The hydrogel is named as the double-deck viscous tough gel of high intensity by the present inventor.
The composite double layer of the present invention glues tough hydrogel, has good market applicability, such as some hydrogel woundplasts
In, it can both meet mechanical strength in the application, having can meet adhesive bandage in application process to the viscosity of human body skin
It is required that and as the carrier layer rich in medicine.This double-deck hydrogel be not only the performance of two kinds of gels plus and, when double
When layer hydrogel is by stress, matrix ductile layers are effectively protected the deformation of sample, and viscosity is used as a kind of power that hinders so that think
Destroying gel needs higher energy, and the composite double layer hydrogel also made is adapted to bigger destruction in application process
Power.
The composite aquogel of the present invention, there can be good biocompatibility with organism, the above is simply with acryloyl
Exemplified by a kind of main monomer of amine, it is suitable for hyaluronic acid, polyvinyl alcohol etc., these and organism have good biology
The material of compatibility, it will so that double-deck hydrogel is more meaningful in the application of medicine and other fields.
The composite aquogel of the present invention, because ductile layers take the hydrophobic aggregation of physics to act on, there is well restorative,
And double-deck viscous layer has multiple adhesion property, in the case of viscous layer is not contaminated, can be repeatedly used for bonding various
Matrix.So this double-layer structure has well restorative, recycled so the double-deck hydrogel that we are invented has
Property.
Specific implementation method
The preparation of the composite double layer hydrogel of embodiment 1
The preparation of container A：
Measure 75.5g deionized waters and be put into and be put into container A with churned mechanically container A, separately weighing 0.5g sodium chloride,
After sodium to be chlorinated is completely dissolved, continues weighing 2g lauryl sodium sulfate and be put into container A, treat that surfactant is completely dissolved
Afterwards, 2g hexyl methacrylates are added in the mixed liquor of container A, after the solution in container is transparent, then take 20g acryloyls
Amine is added in mixed liquor, after acrylamide dissolves, adds 1g light trigger 2- hydroxyls -4- (2- hydroxy ethoxies) -2- methylbenzenes
Acetone.
It is formulated in container B
Measure 70g deionized waters to be put into in churned mechanically container B, 15g gum arabics are dissolved in B, treat solid
After dissolving, 8g gelatin is added, after stirring 2h, addition takes 6g acrylamides to be put into container B, after medicine all dissolving, adds
1g light trigger 2- hydroxyls -4- (2- hydroxy ethoxies) -2- methyl phenyl ketones.
The preparation of hydrogel：
With the liquid 5ml in liquid-transfering gun extracting container A, it is put into special mould, after adding light trigger, is put into light-initiated machine
In, regulation light intensity is 50%, and after light application time is 10min, solution 5ml in container B is added on molded glue rapidly, after
Continuous illumination 20min, light intensity is still 50%, to the end of illumination, takes out sample, and PH to 4.0-6.0 is adjusted to viscous layer, so, high-strength
Prepared by the viscous tough double-deck hydrogel of degree completes.
The preparation of the composite double layer hydrogel of embodiment 2
The preparation of container A：
Measure 75.5g deionized waters and be put into and be put into container A with churned mechanically container A, separately weighing 0.5g sodium chloride,
After sodium to be chlorinated is completely dissolved, continues weighing 1g lauryl sodium sulfate and be put into container A, treat that lauryl sodium sulfate is complete
After dissolving, 1g lauryl methacrylates are added in the mixed liquor of container A, after the solution in container is transparent, then take 22g
Hyaluronic acid acid is added in mixed liquor, after acrylamide dissolves, adds light trigger 2- hydroxy-2-methyl -1- phenyl ketones
（PI 1173）.
The preparation of container B
Measure 70g deionized waters to be put into in churned mechanically container B, take 20g gum arabics to be put into container B, treat medicine
It is to be dissolved to add 5g gelatin completely after product all dissolve, add 1g light trigger 2- hydroxy-2-methyl -1- phenyl ketones（PI
1173）.
The preparation of hydrogel：
With the liquid 5ml in liquid-transfering gun extracting container A, it is put into special mould, after adding light trigger, is put into light-initiated machine
In, regulation light intensity is 50%, and after light application time is 10min, solution 5ml in container B is added on molded glue rapidly, after
Continuous illumination 20min, light intensity is still 50%, to the end of illumination, takes out sample, and PH to 4.0-6.0 is adjusted to viscous layer, so, high-strength
Prepared by the viscous tough double-deck hydrogel of degree completes.The preparation of the composite double layer hydrogel of embodiment 3
Container A formula
Measure 70g deionized waters be put into in churned mechanically container A, continue weigh 7g neopelexes be put into
In container A, after neopelex is completely dissolved, 2g lauryl methacrylates are added to the mixed liquor of container A
In, after the solution in container is transparent, then take 19g acrylamides to add in mixed liquor, after acrylamide dissolves, add 1g light
Initiator 2- hydroxy-2-methyl -1- phenyl ketones（PI 1173）.
The preparation of container B
Measure 70g deionized waters to be put into in churned mechanically container B, take 8g gum arabics to be put into container B, treat medicine
All after dissolving, 21g acrylamides are added, after mixing completely, add light trigger 2- hydroxy-2-methyl -1- phenyl ketones（PI
1173）.
The preparation of hydrogel：
With the liquid 5ml in liquid-transfering gun extracting container A, it is put into special mould, after adding light trigger, is put into light-initiated machine
In, regulation light intensity is 50%, and after light application time is 10min, solution 5ml in container B is added on molded glue rapidly, after
Continuous illumination 20min, light intensity is still 50%, to the end of illumination, takes out sample, and PH to 4.0-6.0 is adjusted to viscous layer, so, high-strength
Prepared by the viscous tough double-deck hydrogel of degree completes.The preparation of the composite double layer hydrogel of embodiment 4
Container A formula
Measure 70g deionized waters be put into in churned mechanically container A, continue weigh 10g gum arabics be put into container A
In, after solid is completely dissolved, 2g hexyl methacrylates are added in the mixed liquor of container A, treat that the solution in container is saturating
After bright, then take 17g methacrylic acids to add in mixed liquor, after methacrylic acid dissolves, add 1g light trigger 2- hydroxyls -4-
(2- hydroxy ethoxies) -2- methyl phenyl ketones.
Container B formula
Measure 70g deionized waters to be put into in churned mechanically container B, take 10g gum arabics to be put into container B, treat medicine
After dissolving, 19g acrylamides are all added into solution for product, stir 2h, after solution clarification, add 1g light trigger 2- hydroxyls
Base -4- (2- hydroxy ethoxies) -2- methyl phenyl ketones.
The preparation of hydrogel：
With the liquid 5ml in liquid-transfering gun extracting container A, it is put into special mould, after adding light trigger, is put into light-initiated machine
In, regulation light intensity is 50%, and after light application time is 10min, solution 5ml in container B is added on molded glue rapidly, after
Continuous illumination 20min, light intensity is still 50%, to the end of illumination, takes out sample, and PH to 4.0-6.0 is adjusted to viscous layer, so, high-strength
Prepared by the viscous tough double-deck hydrogel of degree completes.
The method of double-deck hydrogel is prepared the invention provides a kind of, and has synthesized with good mechanical properties and has glued
Performance is tied, this is not only that research for composite aquogel has impetus, can more prepare some and meet different requirements
Functional aquagel.The composite double layer hydrogel that the present invention synthesizes, mechanical strength have reached 1.3MPa, peel off force intensity and reach
Requirement is arrived, and this composite double layer hydrogel has been proved to have good restorability and multiple caking property
Can, wherein, adhesive property with most of matrix it is verified that have good adhesive property.
Claims (9)
1. a kind of high intensity adhesive double hydrogel, it is characterised in that high intensity layer is by surfactant, hydrophobic monomer, chlorine
Change sodium, the first monomer, deionized water, light trigger composition, its composition is 2-4 parts；1-4 parts；0.5-1 parts；15-20 parts；70-
80th, 0.5-1 parts；
Viscous layer is by 10-15 parts gum arabic, 10-15 parts second comonomer, 70 parts of deionized waters, and 1 part of light trigger group
Into.
2. as described in right 1, the preparation method of high intensity layer and adhesive double hydrogel is as follows：
（a）Measure 70-80 part deionized waters to be put into in churned mechanically 150ml beakers A, separately weigh 0.5-1 part sodium chloride
It is put into container A, weighs 2-4 part surfactants and be put into container A, after solid dissolving, then 1-4 part hydrophobic monomers are added
Enter into the mixed liquor of container A, after the solution in container is transparent, then take the monomer of 15-20 parts first to add in mixed liquor,
Take 5ml mixed liquors be put into special mould C carry out it is light-initiated, trigger light intensity be 50%, trigger time 20min；
（b）Measure 70 parts of deionized waters to be put into in churned mechanically container B, add 5 parts of emulsifying agents or the emulsifying agent of compounding,
After solid dissolving, 5 parts of hydrophobic monomers are added, after stirring 2h, then 19 parts of second comonomer is added into container B, stirs 20min
Afterwards, 1 part of light trigger is added；
The mixed liquid B that will be made, it is added in the mould C of plastic, polymerize again under the conditions of light-initiated, wherein, it is light-initiated
Intensity is 50%, and the initiation time is 20min, and reaction is completed to can obtain composite double layer hydrogel；
（c）After water-setting to be composite composes, hydrogel is taken out into mould, PH modifications are carried out to viscous layer, adjust the PH of viscous layer
To 4.0-6.0 or so, you can good viscosity is made it have, so, there is the hydrogel of double-deck property to be just produced and completes；
The first monomer as described in right 1-2 is acrylamide, hyaluronic acid, polyvinyl alcohol, acrylic acid and its salt, methyl-prop
Combination more than one or both of olefin(e) acid and its salt, polyethyleneglycol diacrylate.
3. the hydrophobic monomer as described in right 1-2 includes：The own fat of methacrylic acid, lauryl fat, metering system
Sour 16 fat.
4. the second comonomer as described in right 1-2 is gum arabic, agar, agarose, gelatin, collagen, fiber egg
In vain, alginate, hyaluronate, chondroitin sulfate, carragheen, gellan gum, guar gum, sesbania gum, chitosan, oxidation are formed sediment
Combination more than one or both of powder.
5. the surfactant as described in right 1-2 includes lauryl sodium sulfate, hexadecyltrimethylammonium chloride, dodecane
The one or two kinds of combinations therein of base benzene sulfonic acid sodium salt, tween, sapn, gum arabic.
6. the initiator as described in right 1-2 is 2- hydroxy-2-methyl -1- phenyl ketones（PI 1173）, 2- hydroxyl -4- (2-
Hydroxy ethoxy) -2- methyl phenyl ketones（2959）In one kind.
7. the initiation method as described in right 1-2 is light-initiated, wherein light-initiated intensity is 50%, the initiation time is 20min.
8. as described in claim 1-2, gum arabic is pharmaceutical grade, it is characterized in that in deionized water molten at room temperature
Xie Du is 50%.
9. as described in right 1-7, obtained physical crosslinking has the transparency with adhesive double hydrogel.
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| CN (1) | CN107513165A (en) |
Cited By (15)
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| CN108219083A (en) * | 2018-02-08 | 2018-06-29 | 北方民族大学 | A kind of grape pip albumen based aquagel and its preparation method and application |
| CN109021166A (en) * | 2018-07-03 | 2018-12-18 | 北京理工大学 | A kind of method that simple and fast prepares high adhesive attraction power hydrogel duplicature |
| CN109513045A (en) * | 2018-11-20 | 2019-03-26 | 温州生物材料与工程研究所 | Albumen based aquagel and preparation method thereof with the double-deck different internal aperture structures |
| CN109675092A (en) * | 2018-12-17 | 2019-04-26 | 西北工业大学 | Multifunctional water gel adhesive and preparation method thereof suitable for dynamic organization's surface high-strength adhesive |
| CN109929073A (en) * | 2019-03-28 | 2019-06-25 | 西北工业大学 | The preparation method of double-network hydrogel based on the crosslinking of coordination cross-linked and hydrophobic association |
| CN109961872A (en) * | 2019-03-14 | 2019-07-02 | 广州穗海新峰医疗设备制造有限公司 | A kind of physiotherapy electrode plate and preparation method thereof |
| CN110229286A (en) * | 2019-05-10 | 2019-09-13 | 台州学院 | A kind of method preparing dissymmetrical structure hydrogel using one step of differences in viscosity and products thereof and application |
| CN110522951A (en) * | 2019-09-11 | 2019-12-03 | 湖南工业大学 | It is a kind of with antifatigue and impact property gel rubber material |
| CN112007211A (en) * | 2020-09-03 | 2020-12-01 | 湖南工业大学 | Biomass-based hydrogel antibacterial wound dressing |
| CN112430290A (en) * | 2019-08-26 | 2021-03-02 | 天津大学 | Kappa-carrageenan-based high-strength double-physical crosslinked hydrogel and preparation method thereof |
| CN112831062A (en) * | 2020-12-31 | 2021-05-25 | 广东工业大学 | Transparent conductive hydrogel with single-side self-adhesion property and preparation method and application thereof |
| CN113292674A (en) * | 2021-05-28 | 2021-08-24 | 吉林大学 | Preparation method and application of novel adhesion and high-conductivity hydrogel |
| CN113577370A (en) * | 2021-07-28 | 2021-11-02 | 华南理工大学 | Janus hydrogel adhesive and preparation method and application thereof |
| CN113663117A (en) * | 2021-08-17 | 2021-11-19 | 南方科技大学 | Anti-swelling biological adhesive and preparation method and application thereof |
| CN114163658A (en) * | 2021-10-08 | 2022-03-11 | 西北大学 | High-adhesion toughness hydrogel based on rapid controllable orthogonal photochemical reaction and preparation method thereof |
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Cited By (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108219083A (en) * | 2018-02-08 | 2018-06-29 | 北方民族大学 | A kind of grape pip albumen based aquagel and its preparation method and application |
| CN108219083B (en) * | 2018-02-08 | 2021-02-02 | 北方民族大学 | Grape seed protein-based hydrogel and preparation method and application thereof |
| CN109021166A (en) * | 2018-07-03 | 2018-12-18 | 北京理工大学 | A kind of method that simple and fast prepares high adhesive attraction power hydrogel duplicature |
| CN109513045B (en) * | 2018-11-20 | 2021-01-15 | 温州生物材料与工程研究所 | Protein-based hydrogel with double layers of different internal pore diameter structures and preparation method thereof |
| CN109513045A (en) * | 2018-11-20 | 2019-03-26 | 温州生物材料与工程研究所 | Albumen based aquagel and preparation method thereof with the double-deck different internal aperture structures |
| CN109675092A (en) * | 2018-12-17 | 2019-04-26 | 西北工业大学 | Multifunctional water gel adhesive and preparation method thereof suitable for dynamic organization's surface high-strength adhesive |
| CN109675092B (en) * | 2018-12-17 | 2021-09-10 | 西北工业大学 | Multifunctional hydrogel adhesive suitable for high-strength bonding of dynamic tissue surface and preparation method thereof |
| CN109961872A (en) * | 2019-03-14 | 2019-07-02 | 广州穗海新峰医疗设备制造有限公司 | A kind of physiotherapy electrode plate and preparation method thereof |
| CN109929073A (en) * | 2019-03-28 | 2019-06-25 | 西北工业大学 | The preparation method of double-network hydrogel based on the crosslinking of coordination cross-linked and hydrophobic association |
| CN110229286A (en) * | 2019-05-10 | 2019-09-13 | 台州学院 | A kind of method preparing dissymmetrical structure hydrogel using one step of differences in viscosity and products thereof and application |
| CN110229286B (en) * | 2019-05-10 | 2021-07-13 | 台州学院 | Method for preparing hydrogel with asymmetric structure in one step by using viscosity difference, product and application thereof |
| CN112430290A (en) * | 2019-08-26 | 2021-03-02 | 天津大学 | Kappa-carrageenan-based high-strength double-physical crosslinked hydrogel and preparation method thereof |
| CN112430290B (en) * | 2019-08-26 | 2023-03-07 | 天津大学 | Kappa-carrageenan-based high-strength double-physical crosslinked hydrogel and preparation method thereof |
| CN110522951A (en) * | 2019-09-11 | 2019-12-03 | 湖南工业大学 | It is a kind of with antifatigue and impact property gel rubber material |
| CN110522951B (en) * | 2019-09-11 | 2021-08-27 | 湖南工业大学 | Gel material with anti-fatigue and anti-impact characteristics |
| CN112007211A (en) * | 2020-09-03 | 2020-12-01 | 湖南工业大学 | Biomass-based hydrogel antibacterial wound dressing |
| CN112007211B (en) * | 2020-09-03 | 2022-04-08 | 湖南工业大学 | Biomass-based hydrogel antibacterial wound dressing |
| CN112831062A (en) * | 2020-12-31 | 2021-05-25 | 广东工业大学 | Transparent conductive hydrogel with single-side self-adhesion property and preparation method and application thereof |
| CN113292674A (en) * | 2021-05-28 | 2021-08-24 | 吉林大学 | Preparation method and application of novel adhesion and high-conductivity hydrogel |
| CN113577370A (en) * | 2021-07-28 | 2021-11-02 | 华南理工大学 | Janus hydrogel adhesive and preparation method and application thereof |
| CN113663117A (en) * | 2021-08-17 | 2021-11-19 | 南方科技大学 | Anti-swelling biological adhesive and preparation method and application thereof |
| CN113663117B (en) * | 2021-08-17 | 2022-06-21 | 南方科技大学 | Anti-swelling biological adhesive and preparation method and application thereof |
| CN114163658A (en) * | 2021-10-08 | 2022-03-11 | 西北大学 | High-adhesion toughness hydrogel based on rapid controllable orthogonal photochemical reaction and preparation method thereof |
| CN114163658B (en) * | 2021-10-08 | 2024-01-19 | 西北大学 | High-adhesion toughness hydrogel based on rapid controllable orthogonal photochemical reaction and preparation method thereof |
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