CN107510458A - A kind of MR imaging method and equipment - Google Patents
A kind of MR imaging method and equipment Download PDFInfo
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- CN107510458A CN107510458A CN201710686293.7A CN201710686293A CN107510458A CN 107510458 A CN107510458 A CN 107510458A CN 201710686293 A CN201710686293 A CN 201710686293A CN 107510458 A CN107510458 A CN 107510458A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
Abstract
The embodiment of the invention discloses a kind of MR imaging method and equipment, this method includes：Target site to be scanned is moved to the scanning chamber of MR imaging apparatus, target site includes the first piecemeal, the second piecemeal along the long axis direction extension of scanning chamber；Apply level selection gradient in left-right direction simultaneously；Excite multiple lamellas of the first piecemeal, the second piecemeal simultaneously using multiple radio-frequency pulses, obtain magnetic resonance signal corresponding to multiple lamellas；Phase code along the longitudinal direction and the frequency coding along long axis direction are applied to magnetic resonance signal respectively, obtain coded data corresponding to magnetic resonance signal；Coded data is packed into two independent K spaces respectively；Two K spaces are carried out with reconstruction processing, obtains the first piecemeal, the MRI of the second piecemeal.The embodiment of the present invention realizes the piecemeal collection to target site, effectively shortens acquisition time, improves collecting efficiency.
Description
Technical field
The present embodiments relate to magnetic resonance imaging technical field, more particularly to a kind of method of magnetic resonance imaging and set
It is standby.
Background technology
MRI (Magnetic Resonance Imaging, magnetic resonance imaging) is to being placed in magnetic field by MRI machine
Human body apply RF pulses (Radio Frequency Pulse, radio-frequency pulse) so that atomic nucleus in human body produces spin shape
Into MR signals (Magnetic Resonance Signal, magnetic resonance signal), image reconstruction is carried out according to MR signals and obtains MRI
Image.MRI machine includes being used for tubular magnet, the tubular coil in the setting of tubular magnet inner coaxial, the gradient for forming magnetic field
Field coil, RF coils, control device and the flat board for carrying human body.Set for the z directions of the space coordinates in MRI machine
The axial direction of tubular magnet or tubular coil is set to, generally the length direction of human body is consistent with z directions and is imaged, it is horizontal
Plane is arranged to xz planes, and x directions are vertical with z directions, and y directions are vertical, vertical with x and z directions.
Currently, being carried out the technology of contrast imaging to periphery lower limb vascular using mr techniques is included：Contrast agent strengthens skill
Art and non-contrast strengthen technology, include 3D imaging technique again in non-contrast enhancing technology.
In 3D imaging technique, as shown in Figure 1a, more modes for use coronal scan are to obtain maximum FOV (Field
Of View, the visual field), coronal-plane overlooks seen face from top to bottom i.e. when human body lies low and detected.In order to be preced with
Shape face image, first carries out choosing layer in scanning process, and level selection encodes direction and carried out on front side of human body to rear side.Such as Fig. 1 b institutes
Show, people side section is also referred to as sagittal plane, and level selection encodes direction on the left of human body to right side.Sweeping for pulse train need to be applied
Retouch direction and be referred to as phase-encoding direction, usually carried out from the direction on human body left side to right side；Magnetic field letter after detection excitation
Number, the magnetic field signal data of reading are filled to the direction in K spaces and are referred to as read direction, usually from human body head to step
What direction was carried out, referring to shown in Fig. 1 a.
Because the characteristics of lower limb scan is that two legs are parallel and independent, thus using coronal-plane from front to back
When level selection encodes direction, the coronal image of two legs gathers simultaneously, and the coronal-plane that number of phase encoding is more than two legs is wide
Degree, acquisition time length, causes imaging efficiency low, reduces the comfort level of patient.
The content of the invention
The embodiment of the present invention provides a kind of method of MRI scan, magnetic resonance imaging equipment and medium, solves existing
Some magnetic resonance imaging acquisition times length, imaging efficiency is low, the problem of patient comfort's difference.
In a first aspect, the embodiments of the invention provide a kind of MRI scan method, this method includes：
Target site to be scanned is moved to the scanning chamber of MR imaging apparatus, the target site is included along scanning
The first piecemeal, the second piecemeal of the long axis direction extension of chamber；
Level selection gradient in left-right direction is applied simultaneously to first piecemeal, the second piecemeal, by the first piecemeal, the
Two piecemeals are divided into multiple lamellas in left-right direction；
Excite multiple lamellas of first piecemeal, the second piecemeal simultaneously using multiple radio-frequency pulses, obtain described first
Piecemeal, the second piecemeal multiple lamellas corresponding to magnetic resonance signal；
Phase code along the longitudinal direction and the frequency coding along long axis direction are applied to the magnetic resonance signal respectively, obtained
Take coded data corresponding to the magnetic resonance signal；
The coded data is packed into two K spaces；
Described two K spaces are carried out with reconstruction processing respectively, obtains the first piecemeal, the MRI of the second piecemeal.
Alternatively, the target site to be scanned includes double lower limb or double upper limbs, left upper extremity or left lower extremity it is corresponding described in
Corresponding second piecemeal of first piecemeal, right upper extremity or right lower extremity.
Alternatively, first piecemeal, the second piecemeal are 3D piecemeals, and each radio-frequency pulse excites described first point simultaneously
Multiple lamellas of multiple lamellas of block or second piecemeal.
Alternatively, methods described also includes：
By the MRI of the MRI of first piecemeal and second piecemeal according to organization of human body position
It is stitched together, generate the MRI of the target site.
Alternatively, multiple lamellas of first piecemeal, the second piecemeal are excited simultaneously using multiple radio-frequency pulses, obtain institute
Magnetic resonance signal corresponding to multiple lamellas of the first piecemeal, the second piecemeal is stated, including：
Multilayer magnetic resonance inspection is carried out respectively to first piecemeal, the second piecemeal using parallel multilayer exciting method simultaneously
Survey.
Alternatively, the multiple radio-frequency pulse includes the insensitive sequence of flow, and methods described also includes：
Detected using the first piecemeal, the second piecemeal described in the insensitive sequence pair of the flow, obtain the first kind
Magnetic resonance signal；
The first kind MRI according to corresponding to the first kind magnetic resonance signal obtains target site.
Alternatively, the multiple radio-frequency pulse also includes the sequence of flow-sensitive, and methods described includes：
Detected using the first piecemeal, the second piecemeal described in the sequence pair of the flow-sensitive, obtain Second Type magnetic
Resonance signal；
The Second Type MRI according to corresponding to the Second Type magnetic resonance signal obtains target site；
The first kind MRI and Second Type MRI are subjected to registration；
From the first kind MRI after registration subtract registration after Second Type MRI, acquisition subtract shadow figure
Picture；
Angiogram corresponding to subtraction image is shown in the form of MIP vascular trees.
Alternatively, the target site includes blood vessel, and methods described also includes：
Within the vessel retraction phase, apply Flow sensitive dephasing gradient magnetic, in the Flow sensitive dephasing gradient magnetic
The gradient magnetic of the after-applied remaining magnetic moment of elimination of field；
Gather the blood flow MRI in the vessel retraction phase；
Gather the blood flow MRI in the vasodilation phase；
Blood flow MRI in blood flow MRI and the diastole in the systole phase is weighted
Or it is nonweighted subtract shadow, obtain blood-stream image.
According to the second aspect of the application, a kind of magnetic resonance imaging equipment is proposed, including：
It is scanning bed, it is described to be scanned for target site to be scanned to be moved to the scanning chamber of MR imaging apparatus
Position includes the first piecemeal, the second piecemeal along the long axis direction extension of scanning chamber；
Radio-frequency coil, for providing radio-frequency pulse, the radio-frequency pulse can excite first piecemeal, the second piecemeal simultaneously
Multiple lamellas, obtain magnetic resonance signal corresponding to multiple lamellas of first piecemeal, the second piecemeal；
Gradient coil, for providing gradient fields, the gradient fields are used to produce level selection coding, phase code and frequency
The gradient fields of coding, to obtain coded data corresponding to the magnetic resonance signal；
One or more processors；
Storage device, for storing one or more programs,
The computing device program, for the coded data to be packed into two K spaces；
Reconstruction processing is carried out to the K spaces, obtains the first piecemeal, the MRI of the second piecemeal.
Alternatively, gradient fields corresponding to the level selection coding are ladder corresponding to the phase code in left-right direction
Field is spent for along the longitudinal direction, gradient fields corresponding to the frequency coding are along long axis direction.
The embodiment of the present invention utilizes RF pulse-to-pulse by the way that target site to be scanned is divided into the first piecemeal and the second piecemeal
Punching excites simultaneously to the first piecemeal and the second piecemeal, realizes the piecemeal collection to target site, shortens acquisition time, improve
Collecting efficiency.
Brief description of the drawings
Technical scheme in order to illustrate the embodiments of the present invention more clearly, make required in being described below to embodiment
Accompanying drawing does one and simply introduced, it should be apparent that, drawings in the following description are some embodiments of the present invention, for this
For the those of ordinary skill of field, on the premise of not paying creative work, it can also be obtained according to these accompanying drawings other
Accompanying drawing.
Fig. 1 a are the coronal scan schematic diagrames that background technology of the embodiment of the present invention provides；
Fig. 1 b are the sagittal scan schematic diagrames that background technology of the embodiment of the present invention provides；
Fig. 2 is a kind of flow chart for MRI scan method that the embodiment of the present invention one provides；
Fig. 3 a are a kind of level selection coding direction schematic diagrams for left lower extremity that the embodiment of the present invention one provides；
Fig. 3 b are a kind of level selection coding direction schematic diagrams for right lower extremity that the embodiment of the present invention one provides；
Fig. 3 c are a kind of phase-encoding direction schematic diagrames for lower limb that the embodiment of the present invention one provides；
Fig. 4 is a kind of MR imaging method that the embodiment of the present invention two provides；
Fig. 5 a are the first kind MRI that the embodiment of the application one is obtained using the insensitive SSFP sequence of flow；
Fig. 5 b are the Second Type MRI that the embodiment of the application one is obtained using the SSFP sequence of flow-sensitive；
Fig. 5 c are to be obtained using the Second Type MRI in the first kind MRI and Fig. 5 b in Fig. 5 a
Subtraction image；
Fig. 5 d are the double lower limb angiogram that MIP acquisition is carried out to Fig. 5 c；
Fig. 6 is a kind of structural representation for magnetic resonance imaging equipment that the embodiment of the present invention three provides.
Embodiment
To make the object, technical solutions and advantages of the present invention clearer, hereinafter with reference to attached in the embodiment of the present invention
Figure, technical scheme is clearly and completely described by embodiment, it is clear that described embodiment is the present invention one
Section Example, rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art are not doing
Go out under the premise of creative work the every other embodiment obtained, belong to the scope of protection of the invention.
The application proposes a kind of MR imaging method, including：Target site to be scanned is moved to magnetic resonance imaging
The scanning chamber of equipment, target site include the first piecemeal, the second piecemeal along the long axis direction extension of scanning chamber, and each piecemeal is
3D (three-dimensional) volumes or volume；Apply aspect in left-right direction simultaneously to the first piecemeal, the second piecemeal
Gradient is selected, the first piecemeal, the second piecemeal are divided into multiple lamellas in left-right direction；Excited simultaneously using multiple radio-frequency pulses
Multiple lamellas of first piecemeal, the second piecemeal, obtain magnetic resonance letter corresponding to multiple lamellas of the first piecemeal, the second piecemeal
Number；Phase code along the longitudinal direction and the frequency coding along long axis direction are applied to magnetic resonance signal respectively, obtain magnetic resonance
Coded data corresponding to signal；Coded data is packed into two K spaces；Two K spaces are carried out with reconstruction processing, obtains first
The MRI of piecemeal, the second piecemeal.Alternatively, merge the first piecemeal, the MRI of the second piecemeal, target can be obtained
The MRI at position.Alternatively, the first piecemeal, the second piecemeal at different moments or under different image-forming conditions are obtained respectively
MRI, can treat scanned position carry out blood vessel imaging or focus detection.It should be noted that the magnetic in the application
Resonance signal may include own sensing deamplification, spin echo signal, gtadient echo signal etc..
Embodiment one
Fig. 2 is a kind of flow chart for MR imaging method that the embodiment of the present invention one provides.The technical side of the present embodiment
Case goes for carrying out the situation of magnetic resonance imaging.This method specifically includes following operation：
S110, the scanning chamber or scanning area that target site to be scanned is moved to MR imaging apparatus, and by institute
At least two three-dimensional piecemeals can be divided into by stating target site, and each three-dimensional piecemeal includes multiple (2D) lamellas.In one embodiment
In, position to be scanned corresponding to three-dimensional piecemeal includes the along the long axis direction system direction of principal axis of chamber (scanning) extension of scanning chamber
One piecemeal, the second piecemeal.Certainly, the long axis direction in the application can also use the above-below direction of person under inspection's target site/from the beginning arrive
Pin direction replaces.
Three-dimensional piecemeal is the part in the target organ with volume.Target organ to be scanned can be had in human body
There is the organ of at least two independent structures, each corresponding three-dimensional piecemeal of independent structure；It can also be an organ
At least two parts, the division of specific each section can be divided at least two isometric parts according to the volume of organ,
Can also be equidistant to be divided at least two parts, the corresponding three-dimensional point of each section according to the axis in organ cross section
Block.It is exemplary, by the head of people according to head cross section axis it is equidistant be divided into three parts, i.e., target organ
Division is for three three-dimensional piecemeals.Target organ is divided at least two three-dimensional piecemeals, it is possible to achieve to the more of target organ
Piecemeal synchronous scanning, shorten sweep time.
Wherein, the target organ to be scanned can include：Double lower limb or double upper limbs.Double lower limb or double upper limbs have only
The vertical structure of left and right two, each structure can correspond to a three-dimensional piecemeal, then described to move target organ to be scanned
To scanning area, and the target organ is divided at least two three-dimensional piecemeals included：
The double lower limb or double upper limbs are moved to scanning area, the double lower limb or double upper limbs are divided into left-right direction
The corresponding three-dimensional piecemeal of two three-dimensional piecemeals, wherein left upper extremity or left lower extremity, right upper extremity or the corresponding three-dimensional point of right lower extremity
Block.Further, for double upper limbs, left upper extremity can correspond to the first piecemeal, and right upper extremity can correspond to the second piecemeal；For double
For lower limb, left lower extremity can correspond to the first piecemeal, and right lower extremity can correspond to the second piecemeal.
S120, using radio-frequency pulse excite described at least two three-dimensional piecemeals simultaneously, obtain corresponding to the three-dimensional piecemeal
Magnetic resonance signal.
By radio-frequency pulse while each three-dimensional piecemeal is excited, the atomic nucleus in each three-dimensional piecemeal is due to the work of radio-frequency pulse
With spin is produced, so as to obtain magnetic resonance signal corresponding to each piecemeal.It is achieved in, the piecemeal of target organ is synchronously adopted
Collection, improve the picking rate of magnetic resonance signal.Wherein, the parameter phase of the radio-frequency pulse of described at least two three-dimensional piecemeals is excited
Together.The parameter includes the amplitude intensity and frequency of pulse.It is possible thereby to ensure that each three-dimensional piecemeal is in identical RF pulse-to-pulse
Rush in environment.
In this embodiment, target site includes the first piecemeal, the second piecemeal along the long axis direction extension of scanning chamber, right
First piecemeal, the second piecemeal apply level selection gradient in left-right direction simultaneously, can be by the first piecemeal, the second piecemeal edge
Left and right directions is divided into multiple lamellas；Excite multiple lamellas of the first piecemeal, the second piecemeal simultaneously using multiple radio-frequency pulses, can
Obtain magnetic resonance signal corresponding to multiple lamellas of the first piecemeal, the second piecemeal.It is possible to further utilize parallel multilayer simultaneously
Exciting method or compression sensing method carry out multilayer magnetic resonance detection to the first piecemeal, the second piecemeal respectively, wherein, compression sense
Perception method refers to document Candes E J, Romberg J, Tao T.Robust uncertainty principles:
Exact signal reconstruction from highly incomplete frequency information[J]
.IEEE Transactions on information theory,2006,52(2):489-509；Parallel multilayer simultaneously excites
Method refers to document Posse S, Ackley E, Mutihac R, et al.Enhancement of temporal
resolution and BOLD sensitivity in real-time fMRI using multi-slab echo-
volumar imaging[J].Neuroimage,2012,61(1):115-130。
S130, apply phase code along the longitudinal direction to the magnetic resonance signal respectively and compiled along the frequency of long axis direction
Code, obtains coded data corresponding to the magnetic resonance signal.
Wherein, the gradient fields Parameter Variation of the different directions applied to each three-dimensional piecemeal is identical.It is described
Parameter includes the amplitude intensity and frequency of pulse.Changing rule for example can be that amplitude intensity is gradually reduced or raised.Thus may be used
To ensure that each three-dimensional piecemeal is in identical gradient fields, avoid causing the situation of error due to the difference of gradient fields.
In magnetic resonance imaging, when human body prostrate or lie on the back when scanning bed upper, fore-and-aft direction (i.e. y directions) can be utilized
Gradient fields to magnetic resonance signal carry out phase code (phase encoding, PE), utilize the ladder in left and right directions (i.e. x directions)
Degree field carries out choosing layer (or layer choosing) coding (slice phase encoding, SPE), utilizes the ladder in above-below direction (i.e. z directions)
Spend field and carry out frequency coding/frequency reading coding (readout encoding, RE).
In three-dimensional MRI, it is necessary first to select layer, frequency coding and phase code are carried out in aspect, magnetic is total to
The signal that shakes is assigned on different location of pixels, so as to form MRI.Such as can utilize left and right directions (counterpart
The left and right directions of body) gradient fields carry out level selection coding, it is vertical that phase-encoding direction and level selection encode direction, i.e. phase
Position coding direction be fore-and-aft direction/along human body front point to side.Certainly, level selection coding direction is also fore-and-aft direction,
Correspondingly, phase-encoding direction is then left and right directions.
Preferably, the gradient fields according to different directions carry out phase code and frequency to the magnetic resonance signal respectively
Coding, obtain the magnetic resonance signal corresponding to coded data include：
Magnetic resonance signal carries out phase code using the gradient fields relative to limbs fore-and-aft direction to the magnetic resonance signal,
Using along limbs the direction of blood flow enter line frequency read coding, obtain coded data corresponding to the magnetic resonance signal.
Exemplarily, Fig. 3 a are the coding direction schematic diagram of left lower extremity coronal-plane；Fig. 3 b are the coding of right lower extremity coronal-plane
Direction schematic diagram；Fig. 3 c are the coding direction schematic diagram of lower limb sagittal plane.When target organ is lower limb, single lower limb such as lower-left
The width of limb or right lower extremity is the half of the width of two lower limb.
In this embodiment, existing method and the present processes are respectively adopted to be scanned person under inspection's lower limb.Adopting
In the cataloged procedure that magnetic resonance signal is carried out with existing method, readout direction is along the direction (from top to bottom) of lower extremity blood flow；Phase
Position coding direction is the left and right directions of relative person under inspection；Level selection direction is the fore-and-aft direction of relative person under inspection.Using existing
When technology is scanned, the 3D volumes of whole lower limb scanning include 72 layers of two dimension slicing, along the coding digit in level selection direction
For 72, the phase code digit along readout direction is 256, and the coding digit along phase-encoding direction is 192.
In the cataloged procedure of magnetic resonance signal is carried out using the application method, person under inspection's lower limb are divided into two three-dimensionals in left and right
Piecemeal, i.e. the first piecemeal and the second piecemeal, for each three-dimensional piecemeal：Readout direction is (from the beginning to be arrived along the direction of lower extremity blood flow
Pin) or long axis direction；Phase-encoding direction is the fore-and-aft direction of relative person under inspection；Level selection direction is the left side of relative person under inspection
Right direction.When being scanned using the application, each three-dimensional piecemeal includes 72 layers of two dimension slicing, along the coding in level selection direction
Digit is 72, is 256 along the phase code digit of readout direction, is swept because the left-right parts of lower limb carry out three-dimensional piecemeal respectively
Retouch, target area can remove nontarget area, and the coding digit along phase-encoding direction is 80.
The gradient fields of selection left and right directions carry out level selection coding to single lower limb and compared using fore-and-aft direction respectively
Gradient fields carry out level selection coding together to two lower limb, and group/cording quantity reduces half, improves coding rate.It is simultaneously right
The single lower limb for carrying out level selection coding respectively carry out phase code, obtain coded data corresponding to single lower limb.
S140, the coded data is packed into two K spaces, the K spaces and the first piecemeal, the second piecemeal one a pair
Should.K spaces in the application are three-dimensional K spaces, and each coding site in the three-dimensional K spaces can be corresponded in subsequent reconstruction image
Multiple pixels.
Coded data corresponding to the magnetic resonance signal of each three-dimensional piecemeal is filled into each K space respectively.K spaces
Also referred to as Fourier space, is the packing space of the coded data with space orientation coding information, and each width MR images have it
Corresponding K space data dot matrix.Fourier transform is carried out to data in K spaces, obtains different frequency corresponding to coded data, phase
Position and the MR data signals of amplitude, MR data signals are assigned in corresponding pixel and obtain MR images.
S150, reconstruction processing is carried out to the K spaces, obtain multiple slice images or two 3-D views, Mei Gesan
Dimension image can include multiple two-dimensional slice images.
First piecemeal and the second piecemeal correspond to a K space respectively, every K spaces rebuild processing obtain it is each
Image corresponding to three-dimensional piecemeal.
Further, it may also include S160, the multiple slice image be reconstructed processing, obtain target organ/portion
MRI corresponding to position.Exemplarily, can by the first obtained piecemeal, the second piecemeal MRI according to object machine
The position relationship arrangement of three-dimensional piecemeal can obtain MRI corresponding to target organ in official.
In another preferred embodiment of the present invention, processing is being reconstructed to the multiple slice image, is obtaining target
After MRI corresponding to organ, in addition to：By MRI corresponding to each three-dimensional piecemeal according to organization of human body position
Put stitched together shown.Facilitate the complete image of user's acquisition target organ with this, it is convenient based on the whole of target organ
Body is analyzed.
The present embodiment utilizes radio-frequency pulse pair by the way that target site to be scanned is divided into the first piecemeal, the second piecemeal
The three-dimensional piecemeal that marks off while excite, realize the piecemeal collection to target site, shorten acquisition time, improve collection
Efficiency.
Embodiment two
Fig. 4 is a kind of MR imaging method that the embodiment of the present invention two provides.The embodiment of the present invention is in above-described embodiment
On the basis of, further define the target site and be divided into two three-dimensional piecemeals, and the radio-frequency pulse includes flow
The insensitive sequence of insensitive sequence and/or the sequence of flow-sensitive, wherein flow and/or the sequence of flow-sensitive may include
Quick free echo sequence (fast spin echo, FSE), turbo inversion recovery magnitude sequence (fast inversion
Recovery, FIR), gradin-echo (gradient recalled echo, GRE), common stable state have by oneself precession
(steady state free precession, SSFP) sequence, Echo-plane imaging (echo planar imaging, EPI)
Sequence etc.
The insensitive sequence of the flow of the present embodiment and the sequence of flow-sensitive illustrate that this method includes by taking SSFP as an example：
S210, the scanning chamber that target organ to be scanned is moved to MR imaging apparatus, and by the target organ
Be divided into two three-dimensional piecemeals, two three-dimensional piecemeals include along scanning chamber long axis direction extension the first piecemeal, second point
Block.
Exemplarily, corresponding first piecemeal of left lower extremity, right lower extremity include the second piecemeal, and each three-dimensional piecemeal includes multiple
Layer.
S220, level selection gradient in left-right direction is applied simultaneously to the first piecemeal, the second piecemeal, by the first piecemeal,
Second piecemeal is divided into multiple lamellas in left-right direction.
S230, excite the first piecemeal, the second piecemeal simultaneously using radio-frequency pulse, the first piecemeal of acquisition, the second piecemeal are corresponding
Proton imaging signal or magnetic resonance imaging signal, the radio-frequency pulse include insensitive SSFP (the steady state of flow
Free precession, SSFP) steady state free precession gradin-echo and/or flow-sensitive SSFP sequence.
S240, for each three-dimensional piecemeal in two three-dimensional piecemeals, utilize the insensitive SSFP sequence of the flow
Three-dimensional piecemeal is detected, obtains first kind magnetic resonance signal, target is obtained according to the first kind magnetic resonance signal
First kind MRI corresponding to organ.
S250, using the SSFP sequence of the flow-sensitive three-dimensional piecemeal is detected, obtain Second Type magnetic resonance
Signal, the Second Type MRI according to corresponding to the Second Type magnetic resonance signal obtains target organ.
Make following operation to magnetic resonance signal corresponding to two three-dimensional piecemeals respectively：First kind magnetic resonance signal is carried out
Level selection encodes and phase code, obtains coded data corresponding to magnetic resonance signal；Second Type magnetic resonance signal is carried out
Level selection encodes and phase code, obtains coded data corresponding to magnetic resonance signal.The coded data is packed into two K
Space, one of K spaces correspond to the insensitive SSFP sequence of flow, and rebuilding the K spaces can obtain corresponding to target organ
One type MRI；Another K space corresponds to the SSFP sequence of flow-sensitive, and target organ can be obtained by rebuilding the K spaces
Corresponding Second Type MRI.
S260, the first kind MRI and Second Type MRI be subjected to registration.
The method of image registration can use existing method for registering, such as can be correlation method, Atlas Method or surface method
Deng.Method for registering images is respectively adopted first kind MRI is subjected to registration, Second Type MRI is carried out
Registration.
S270, the Second Type MRI after registration is subtracted from the first kind MRI after registration, obtained
Subtraction image.
The pixel value of each pixel of first kind MRI after registration subtracts the Second Type magnetic after registration
The pixel value of each pixel of resonance image, obtains subtraction image.
S280, double lower limb angiogram corresponding to subtraction image is shown in the form of MIP vascular trees.
The present embodiment is by using the SSFP sequence of the insensitive SSFP sequence of flow and flow-sensitive respectively to three-dimensional point
Block is scanned, and is obtained first kind MRI and Second Type MRI respectively, is utilized the image phase after registration
Subtract to obtain sketch figure picture, realize the accurate acquisition of angiogram.
In another embodiment, target site includes blood vessel, MR imaging method, including：
Within the vessel retraction phase, apply Flow sensitive dephasing gradient magnetic, in the Flow sensitive dephasing gradient magnetic
The gradient magnetic of the after-applied remaining magnetic moment of elimination of field；
The blood flow MRI in the vessel retraction phase is gathered, acquisition method refers to above-described embodiment；
The blood flow MRI in the vasodilation phase is gathered, acquisition method refers to above-described embodiment；
Blood flow MRI in blood flow MRI and the diastole in systole phase is weighted or
It is nonweighted to subtract shadow, obtain blood-stream image.
If Fig. 5 a are the first kind magnetic resonance figure that the embodiment of the application one is obtained using the insensitive SSFP sequence of flow
Picture, wherein, the pixel value of the blood in blood vessel is similar with the muscle of surrounding or bone etc., is shown as high gray scale or dark letter
Number.Second Type MRI such as Fig. 5 b for the embodiment of the application one using the SSFP sequence acquisition of flow-sensitive, wherein,
The pixel value of blood in blood vessel is shown as low gray scale or bright signal, and the pixel value of the muscle of surrounding or bone is shown as
High gray scale or dark signal.If Fig. 5 c are to be total to using the Second Type magnetic in the first kind MRI and Fig. 5 b in Fig. 5 a
The subtraction image that the image that shakes obtains, the image of blood vessel is only shown in the subtraction image.If Fig. 5 d are to carry out maximal density to Fig. 5 c
The double lower limb angiogram obtained is projected, figure medium vessels is high-visible, and sharp contrast is formed with surrounding tissue.
Embodiment three
Fig. 6 is a kind of structural representation for magnetic resonance imaging equipment that the embodiment of the present invention three provides, and the equipment includes sweeping
Bed is retouched, for target site to be scanned to be moved to the scanning chamber of scanning area or MR imaging apparatus, the target portion
Position is divided into two or more three-dimensional piecemeals, and long axis direction of each three-dimensional piecemeal along scanning chamber extends and including multiple lamellas；
Radio-frequency coil, for providing radio-frequency pulse, the radio-frequency pulse can excite described at least two three-dimensional piecemeals simultaneously, described in acquisition
Magnetic resonance signal corresponding to three-dimensional piecemeal；Gradient coil, for providing gradient fields, the gradient fields are used to believe the magnetic resonance
Number level selection coding, phase code and frequency coding are carried out, obtain coded data corresponding to the magnetic resonance signal.Wherein sweep
Bed, gradient coil and radio-frequency coil is retouched to be not drawn into figure.As shown in fig. 6, the equipment also include processor 30, memory 31,
Input unit 32 and output device 33；The quantity of processor 30 can be one or more in equipment, with a processor in Fig. 6
Exemplified by 30, the computing device program, for the coded data to be packed into two K spaces, the K spaces and described three
Piecemeal is tieed up to correspond；Reconstruction processing is carried out to the K spaces, obtains two MRIs (three-dimensional)；To two magnetic resonance
Processing is reconstructed in image, obtains MRI corresponding to target organ.The gradient fields are additionally operable to believe the magnetic resonance
Number frequency coding is carried out, gradient fields are along relative to limbs left and right directions, the phase code corresponding to level selection coding
Corresponding gradient fields are along limbs fore-and-aft direction, and gradient fields corresponding to the frequency coding are along the blood flow direction in limbs.In equipment
Processor 30, memory 31, input unit 32 can be connected with output device 33 by bus or other modes, in Fig. 6 with
Exemplified by being connected by bus.
Memory 31 is used as a kind of computer-readable recording medium, and journey is can perform available for storage software program, computer
Sequence and module, programmed instruction/module as corresponding to the MR imaging method in the embodiment of the present invention.Processor 30 passes through fortune
Row is stored in software program, instruction and module in memory 31, so as to perform the various function application of equipment and data
Processing, that is, the method for realizing above-mentioned MRI scan.
Memory 31 can mainly include storing program area and storage data field, wherein, storing program area can store operation system
Application program needed for system, at least one function；Storage data field can store uses created data etc. according to terminal.This
Outside, memory 31 can include high-speed random access memory, can also include nonvolatile memory, for example, at least a magnetic
Disk storage device, flush memory device or other non-volatile solid state memory parts.In some instances, memory 31 can be further
Including network connection to equipment can be passed through relative to the remotely located memory of processor 30, these remote memories.It is above-mentioned
The example of network includes but is not limited to internet, intranet, LAN, mobile radio communication and combinations thereof.
Input unit 32 can be used for the numeral or character information for receiving input, and produce set with the user of equipment and
The relevant key signals input of function control.Output device 33 may include the display devices such as display screen.
Example IV
The embodiment of the present invention four also provides a kind of storage medium for including computer executable instructions, and the computer can be held
Row instruction is used to perform a kind of MR imaging method when being performed by computer processor, and this method includes：
Target site to be scanned is moved to the scanning chamber of MR imaging apparatus, the target site is included along scanning
The first piecemeal, the second piecemeal of the long axis direction extension of chamber；
Level selection gradient in left-right direction is applied simultaneously to first piecemeal, the second piecemeal, by the first piecemeal, the
Two piecemeals are divided into multiple lamellas in left-right direction；
Excite multiple lamellas of first piecemeal, the second piecemeal simultaneously using multiple radio-frequency pulses, obtain described first
Piecemeal, the second piecemeal multiple lamellas corresponding to magnetic resonance signal；
Phase code along the longitudinal direction and the frequency coding along long axis direction are applied to the magnetic resonance signal respectively, obtained
Take coded data corresponding to the magnetic resonance signal；
The coded data is packed into two K spaces；
Described two K spaces are carried out with reconstruction processing respectively, obtains the first piecemeal, the MRI of the second piecemeal.
Certainly, a kind of storage medium for including computer executable instructions that the embodiment of the present invention is provided, its computer
The operation of method that executable instruction is not limited to the described above, can also carry out magnetic resonance that any embodiment of the present invention provided into
Associative operation in image space method.
By the description above with respect to embodiment, it is apparent to those skilled in the art that, the present invention
It can be realized by software and required common hardware, naturally it is also possible to realized by hardware, but the former is more in many cases
Good embodiment.Based on such understanding, what technical scheme substantially contributed to prior art in other words
Part can be embodied in the form of software product, and the computer software product can be stored in computer-readable recording medium
In, floppy disk, read-only storage (Read-Only Memory, ROM), random access memory (Random such as computer
Access Memory, RAM), flash memory (FLASH), hard disk or CD etc., including some instructions are causing a magnetic resonance to sweep
Retouch the method described in each embodiment of the equipment execution present invention.
It is worth noting that, in the embodiment of the performs device of above-mentioned limiting operation, included unit and module
Simply divided according to function logic, but be not limited to above-mentioned division, as long as corresponding function can be realized；
In addition, the specific name of each functional unit is also only to facilitate mutually distinguish, the protection domain being not intended to limit the invention.
Pay attention to, above are only presently preferred embodiments of the present invention and institute's application technology principle.It will be appreciated by those skilled in the art that
The invention is not restricted to specific embodiment described here, can carry out for a person skilled in the art various obvious changes,
Readjust and substitute without departing from protection scope of the present invention.Therefore, although being carried out by above example to the present invention
It is described in further detail, but the present invention is not limited only to above example, without departing from the inventive concept, also
Other more equivalent embodiments can be included, and the scope of the present invention is determined by scope of the appended claims.
Claims (10)
1. a kind of MR imaging method, including：
Target site to be scanned is moved to the scanning chamber of MR imaging apparatus, the target site is included along scanning chamber
The first piecemeal, the second piecemeal of long axis direction extension；
Level selection gradient in left-right direction is applied simultaneously to first piecemeal, the second piecemeal, by the first piecemeal, second point
Block is divided into multiple lamellas in left-right direction；
Excite multiple lamellas of first piecemeal, the second piecemeal simultaneously using multiple radio-frequency pulses, obtain first piecemeal,
Magnetic resonance signal corresponding to multiple lamellas of second piecemeal；
Phase code along the longitudinal direction and the frequency coding along long axis direction are applied to the magnetic resonance signal respectively, obtain institute
State coded data corresponding to magnetic resonance signal；
The coded data is packed into two K spaces；
Described two K spaces are carried out with reconstruction processing respectively, obtains the first piecemeal, the MRI of the second piecemeal.
2. MR imaging method according to claim 1, it is characterised in that the target site to be scanned includes double
Lower limb or double upper limbs, left upper extremity or left lower extremity correspond to first piecemeal, right upper extremity or corresponding second piecemeal of right lower extremity.
3. MR imaging method according to claim 1, it is characterised in that first piecemeal, the second piecemeal are 3D
Piecemeal, and each radio-frequency pulse excites multiple lamellas of first piecemeal or multiple lamellas of second piecemeal simultaneously.
4. MR imaging method according to claim 1, it is characterised in that methods described also includes：
By the MRI of the MRI of first piecemeal and second piecemeal according to the split of organization of human body position
Together, the MRI of the target site is generated.
5. MR imaging method according to claim 1, it is characterised in that excite institute simultaneously using multiple radio-frequency pulses
Multiple lamellas of the first piecemeal, the second piecemeal are stated, obtain magnetic resonance corresponding to multiple lamellas of first piecemeal, the second piecemeal
Signal, including：
Multilayer magnetic resonance detection is carried out respectively to first piecemeal, the second piecemeal using parallel multilayer exciting method simultaneously.
6. according to the MR imaging method described in any one of claim 1 to 5, it is characterised in that the multiple radio-frequency pulse
Including the insensitive sequence of flow, methods described also includes：
Detected using the first piecemeal, the second piecemeal described in the insensitive sequence pair of the flow, obtain first kind magnetic and be total to
Shake signal；
The first kind MRI according to corresponding to the first kind magnetic resonance signal obtains target site.
7. MR imaging method according to claim 6, it is characterised in that the multiple radio-frequency pulse also includes flow
Sensitive sequence, methods described include：
Detected using the first piecemeal, the second piecemeal described in the sequence pair of the flow-sensitive, obtain Second Type magnetic resonance
Signal；
The Second Type MRI according to corresponding to the Second Type magnetic resonance signal obtains target site；
The first kind MRI and Second Type MRI are subjected to registration；
From the first kind MRI after registration subtract registration after Second Type MRI, obtain subtraction image；
Angiogram corresponding to subtraction image is shown in the form of MIP vascular trees.
8. MR imaging method according to claim 1, it is characterised in that the target site includes blood vessel, described
Method also includes：
Within the vessel retraction phase, apply Flow sensitive dephasing gradient magnetic, the Flow sensitive dephasing gradient magnetic it
The after-applied gradient magnetic for eliminating remaining magnetic moment；
Gather the blood flow MRI in the vessel retraction phase；
Gather the blood flow MRI in the vasodilation phase；
Blood flow MRI in blood flow MRI and the diastole in the systole phase is weighted or
It is nonweighted to subtract shadow, obtain blood-stream image.
9. a kind of magnetic resonance imaging equipment, including：
It is scanning bed, for target site to be scanned to be moved to the scanning chamber of MR imaging apparatus, the position to be scanned
Include the first piecemeal, the second piecemeal of the long axis direction extension along scanning chamber；
Radio-frequency coil, for providing radio-frequency pulse, the radio-frequency pulse can excite simultaneously first piecemeal, the second piecemeal it is more
Individual lamella, obtain magnetic resonance signal corresponding to multiple lamellas of first piecemeal, the second piecemeal；
Gradient coil, for providing gradient fields, the gradient fields are used to produce level selection coding, phase code and frequency coding
Gradient fields, to obtain coded data corresponding to the magnetic resonance signal；
One or more processors；
Storage device, for storing one or more programs,
The computing device program, for the coded data to be packed into two K spaces；
Reconstruction processing is carried out to the K spaces, obtains the first piecemeal, the MRI of the second piecemeal.
10. magnetic resonance imaging equipment according to claim 9, it is characterised in that ladder corresponding to the level selection coding
Field is spent in left-right direction, gradient fields corresponding to the phase code are gradient corresponding to the frequency coding along the longitudinal direction
Field is along long axis direction.
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