CN107510455A - A kind of Corneal electrode and preparation method and application - Google Patents
A kind of Corneal electrode and preparation method and application Download PDFInfo
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- CN107510455A CN107510455A CN201710722773.4A CN201710722773A CN107510455A CN 107510455 A CN107510455 A CN 107510455A CN 201710722773 A CN201710722773 A CN 201710722773A CN 107510455 A CN107510455 A CN 107510455A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/398—Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
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Abstract
The present invention provides a kind of flexible and transparent, can be brought into close contact with cornea, be able to record the Corneal electrode of high-quality signal.The Corneal electrode mainly includes curved substrate made of flexible clear materials；Graphene conductive layer, side and the concave side of the curved substrate are compound, opposite side and Corneal Contact to be measured, for gathering the retina electric signal on cornea；And the plain conductor of connection graphene conductive layer, for connecting electrophysiological recording instrument, the signal collected is recorded in real time.The flexible contact mirror class Corneal electrode based on graphene of the present invention, while more preferable patient's usage experience is provided, ensures good translucency and electric conductivity.After tested, available for the measurement of the electric and multifocal retina electricity of full visual field retina, while more traditional electrode has more preferable susceptibility recorded higher signal amplitude to the electrode.
Description
Technical field
The present invention relates to a kind of Corneal electrode and preparation method and application.
Background technology
Retina power technology is a kind of a kind of method for assessment retinal function that clinical and scientific research is commonly used.The technical notes
Caused result is presented by electroretinogram (Electroretinogram, ERG).Different, the retina according to the emphasis of record
Electrograph include full Field Electroretinogram (full-fieldERG, ffERG) and multiple-focus electroretinogram (multi-focalERG,
mfERG)。
The collection of retina electric signal is gathered by retina electricity electrode：One recording electrode note being placed on cornea
The electrical activity for recording the retina electricity under specific light stimulus reflects on cornea.
Conventional retina electricity electrode can substantially be divided into three classes, and one kind is contact lens class electrode, and one kind is wire
Electrode, also one kind are tinsel electrodes.The electrode of contact lense class is often plastic-substrates, and sense of discomfort is had when wearing,
The reason for as well as translucency and changing ophthalmic refractive, it is unsuitable to do multifocal electroretinogram；Wire electrode and gold
Category foil electrode is usually placed at eyes conjunctiva, because corneal does not cause to cover, available for the record of multifocal retina electricity, but
Its resistance also tends to be more than contact lense class electrode, and because electrode is placed at eyes conjunctiva, the electroretinogram that recorded is believed
Number amplitude it is smaller, stability is also poor.
The content of the invention
It is an object of the invention to provide a kind of flexible and transparent, can be brought into close contact with cornea, be able to record that high quality regards
Feel the Corneal electrode of electricity physiological signal such as electroretinogram.
Its structure of Corneal electrode provided by the present invention is as shown in figure 1, mainly include curved surface made of flexible clear materials
Substrate；Graphene conductive layer, side and the concave side of the curved substrate are compound, opposite side and Corneal Contact to be measured, for gathering
Retina electric signal on cornea；And the plain conductor of connection graphene conductive layer, for connecting electrophysiological recording instrument, to adopting
The signal collected is recorded in real time.
The shapes and sizes of the curved substrate can be customized according to the shapes and sizes of the cornea of user, in principle can be by
Any flexible clear materials are made, and the base material that example is shown in the present invention is Parylene-C (c-type Parylene).
Corneal electrode provided by the present invention one or two is prepared by the following method：
Method one：
1) graphene is grown on copper foil；
2) PMMA (polymethyl methacrylate) is applied to the side of copper foil growth graphene, then etches away copper foil,
Obtain PMMA/ graphene double-deckers；
3) the PMMA sides of the PMMA/ graphenes double-decker are attached on the convex surface of curved surface quartz glass, obtained
Graphene/PMMA/ quartz glass composite constructions；
4) flexible transparent film is grown on the graphenic surface of the graphene/PMMA/ quartz glass composite constructions, obtained
To flexible transparent film/graphene/PMMA/ quartz glass composite constructions；
5) PMMA in the flexible transparent film/graphene/PMMA/ quartz glass composite constructions is removed, so that will
Quartz glass separates, and obtains flexible transparent film/graphene composite structure；
6) using conductive silver glue the curved surface concave side of flexible transparent film/graphene composite structure marginal position by wire
Connected with graphene, obtain Corneal electrode.
In above method step 1), it can be existed by chemical vapor deposition (Chemical Vapor Deposition, CVD)
Graphene is grown on copper foil.
In above method step 3), the shapes and sizes of the curved surface quartz glass and the curved substrate of target Corneal electrode
Shapes and sizes it is consistent, be pre-designed according to the shapes and sizes of the cornea of user.
In above method step 4), can by chemical vapor deposition graphene/PMMA/ quartz glass composite constructions table
Flexible transparent film is grown on face.
The material of the flexible transparent film concretely Parylene-C.
In above method step 5), acetone solution can be used to remove flexible transparent film/graphene/PMMA/ quartz glass
PMMA in composite construction, flexible transparent film/graphene is set to be separated with quartz glass.
The above method after step 6), also including the use of epoxide-resin glue coat the glue bond position prevent wire and
Elargol directly contacts the operation of cornea.
Method two：
A) graphene is grown on the convex side of curved surface quartz glass, obtains graphene/quartz glass composite construction；
B) flexible transparent film is grown in the graphenic surface of the graphene/quartz glass composite construction, obtains flexibility
Transparent membrane/graphene/quartz glass composite construction；
C) quartz glass in the flexible transparent film/graphene/quartz glass composite construction is removed, is obtained flexible saturating
Bright film/graphene composite structure；
D) using conductive silver glue the curved surface concave side of flexible transparent film/graphene composite structure marginal position by wire
Connected with graphene, obtain Corneal electrode.
In above method step a), the shapes and sizes of the curved surface quartz glass and the curved substrate of target Corneal electrode
Shapes and sizes it is consistent, be pre-designed according to the shapes and sizes of the cornea of user.
In above method step a), graphene can be grown on curved surface quartz glass by chemical vapour deposition technique.
, can be by chemical vapour deposition technique on the surface of graphene/quartz glass composite construction in above method step b)
Grow flexible transparent film.
The material of the flexible transparent film concretely Parylene-C.
In step c), by etching the quartz removed in the flexible transparent film/graphene/quartz glass composite construction
Glass, obtain flexible transparent film/graphene composite structure.
The Corneal electrode of the present invention has the following advantages that：
The compatible existing measuring system of this kind of electrode；Simultaneously because more frivolous softness, can preferably attach cornea, band
Carry out more preferable Consumer's Experience；Electrode integrally has higher light transmittance, and conductive material covers whole cornea, so as to whole cornea all
Signal is contributed.The signal amplitude that the good electric conductivity of graphene to measure is higher than traditional electrode, there is higher sensitivity；
Relatively low cost can realize electrode consumptive material, avoid cross-infection caused by electrode reuse.
Brief description of the drawings
Fig. 1 is the structural representation of Corneal electrode provided by the present invention, wherein, 1 is flexible and transparent substrate, and 2 be graphite
Alkene conductive layer, 3 be plain conductor.
Fig. 2 be Corneal electrode provided by the present invention and commercial JET electrodes on machin cornea, according to
International Society for Clinical Electrophysiology of Vision (ISCEV) standard,
Measure the result of full visual field retina electricity.The measurement result of JET electrodes represents that (GRACE) electrode of the invention is used with dash-dotted gray line
Solid black lines represent.According to order from left to right from top to bottom, six subgraphs correspond to six detections in ISCEV respectively
Mesh：Dark-adapted 0.01ERG, Dark-adapted 3.0ERG, Dark-adapted OPs, Dark-adapted
10.0ERG, Light-adapted 3.0ERG, Light-adapted 30Hz flicker.The contrast of six results can accordingly
To find that the electrode of the invention used can recorded the signal of larger amplitude than the JET electrodes of commercialization.
Fig. 3 be Corneal electrode provided by the invention on machin cornea, according to International Society for
Clinical Electrophysiology of Vision (ISCEV) standard, measure the result of multifocal retina electricity.According to
From left to right order from top to bottom, eyeground stimulates the schematic diagram of grid when being followed successively by multifocal retina electrographic recording；It recorded
Data；The Two dimensional Distribution of maximum in the waveform presented with thermal map mode；According to result of the retina subregion after average.
Embodiment
Below by specific embodiment, the present invention will be described, but the invention is not limited in this.
Experimental method used in following embodiments is conventional method unless otherwise specified；Institute in following embodiments
Reagent, biomaterial etc., unless otherwise specified, commercially obtain.
The preparation of embodiment 1, Corneal electrode
The first scheme
Use the graphene grown on copper foil
The life on smooth copper foil using the method for chemical vapor deposition (ChemicalVapor Deposition, CVD)
Long graphene；
PMMA is spun to the side of copper foil growth graphene, then falls copper foil using etchant；
The PMMA sides of obtained PMMA graphene double-deckers are attached to the curved surface quartz glass being pre-designed before
Convex side on；
Grown using chemical vapor deposition on the surface of graphene obtained in the previous step/PMMA/ quartz glass
Parylene-C films, obtain the layer structure of Parylene-C/ graphenes/PMMA/ quartz glass；
The PMMA among previous step complex is removed using acetone, separates quartz glass, so as to obtain
The composite construction of Parylene-C/ graphenes, obtains curved surface electrode；
Second scheme
Use the graphene grown on quartz glass
Graphene is grown on designed curved surface quartz glass using CVD, obtains the structure of graphene/quartz glass；
Using CVD in said structure superficial growth Parylene-C, Parylene-C/ graphenes/quartz glass is obtained
Structure；
Fall quartz glass using etchant, obtain the expected structure of Parylene-C/ graphenes, obtain curved surface electricity
Pole；
The marginal position of the interior survey of the curved surface electrode obtained using conductive silver glue in the first scheme or second scheme will
Wire connects with graphene；Coated in elargol bond locations using epoxide-resin glue, prevent wire and elargol from directly contacting cornea,
Obtain Corneal electrode.
The application of Corneal electrode prepared by embodiment 2, embodiment 1 in full visual field retina electrical measurement
The experiment purpose is in the electrode provided in the embodiment of the present invention 1 is contrasted and commercial JET electrodes in full retina
Difference on electric signal measurement, used measuring system are Roland RETImap systems, and the experimental animal used is food crab
Monkey.
Experimental animal prepares：
First by experimental animal mydriasis and anaesthetize, while carry out the dark adaptation of 20 minutes.
The placement of electrode：
It is the electrode and JET electrodes prepared in the embodiment of the present invention 1 that this experiment, which uses electrode,.Electrode in the present invention is put
Prevent that eyes are dry and astringent in measurement process on experimental animal cornea, filling a small amount of artificial tears between electrode and cornea.Placing
Platinum needle electrode is pierced under skin by the outer canthus side of electrode eyes, as reference electrode.
Commercial JET electrodes are placed on the cornea of an other eyes, and a small amount of artificial tears is filled between electrode and cornea
Prevent that eyes are dry and astringent in measurement process.Under platinum needle electrode is pierced into skin in the outer canthus side for placing electrode eyes, as JET
The reference electrode of electrode.
Another platinum needle electrode is pierced under experimental animal back skin, the ground shared as both the above Corneal electrode
Electrode.So far there are two recording electrodes and corresponding reference electrode and a shared ground electrode, totally five electrode connections
To experimental animal.
The record of signal：
Five electrodes above are connected on the amplifier of measuring system, carried out according to flow on the instrument of measuring system
Signal record under different stimulated.Then, the position of two cornea Top electrodes is exchanged, other wheel signal record is carried out, with row
The error brought except the difference of right and left eyes.
The processing and analysis of signal：
The signal extraction characteristic information that will be recorded, and contrast the signal that two kinds of electrodes recorded on same eyes
Difference.
Fig. 2 be Corneal electrode provided by the present invention and commercial JET electrodes on machin cornea, according to
International Society for Clinical Electrophysiology of Vision (ISCEV) standard,
Measure the result of full visual field retina electricity.The measurement result of JET electrodes represents that (GRACE) electrode of the invention is used with dash-dotted gray line
Solid black lines represent.Surveyed object is same eyes, and Dark- is followed successively by according to order from left to right from top to bottom
Adapted 0.01ERG, Dark-adapted 3.0ERG, Dark-adapted OPs, Dark-adapted 10.0ERG,
Light-adapted 3.0ERG, Light-adapted 30Hz flicker.By contrasting it can be found that electrode phase of the present invention
For commercial JET electrodes while signal shape is not changed, there is higher signal amplitude, it is possible to provide more signal details.
The application of example 3, electrode in multifocal retina electrical measurement
The experiment purpose can be used in the survey of multifocal retina electricity in the electrode prepared in the embodiment of the present invention 1 is verified
Amount, used measuring system is Roland RETImap systems, the use of experimental animal is machin.
Experimental animal prepares：
First by experimental animal mydriasis and anaesthetize, while carry out the dark adaptation of 20 minutes.
The placement of electrode：
It is the electrode prepared in the embodiment of the present invention 1 that this experiment, which uses electrode,.It is dynamic that electrode in the present invention is placed in experiment
On object angle film, a small amount of artificial tears is filled between electrode and cornea prevents that eyes are dry and astringent in measurement process.Placing electrode eyes
Outer canthus side by platinum needle electrode be pierced into skin under, as reference electrode.
Another platinum needle electrode is pierced under experimental animal back skin, the ground electrode as Corneal electrode above.Extremely
This has a recording electrode and corresponding reference electrode and a ground electrode, and totally three electrodes are connected to experimental animal.
The record of signal：
Three electrodes above are connected on the amplifier of measuring system, carried out according to flow on the instrument of measuring system
Signal record under different stimulated.
The processing and analysis of signal：
According to routine inspection, experimental data is shown with Fig. 3.
Fig. 3 be Corneal electrode provided by the invention on machin cornea, according to according to International Society
For Clinical Electrophysiology of Vision (ISCEV) standard, measure the result of multifocal retina electricity.
According to order from left to right from top to bottom, eyeground stimulates the schematic diagram of grid when being followed successively by multifocal retina electrographic recording；Record
The data arrived；The Two dimensional Distribution of maximum in the waveform presented with thermal map mode；According to result of the retina subregion after average.It is real
Verify that the electrode in the bright present invention can be used for recording multifocal electroretinal signal, while have good signal quality.
Claims (5)
1. a kind of Corneal electrode, include curved substrate made of flexible clear materials；Graphene conductive layer, side and the curved surface
The concave side of substrate is compound, opposite side and Corneal Contact to be measured；And the plain conductor of connection graphene conductive layer.
2. Corneal electrode according to claim 1, it is characterised in that：The shapes and sizes of the curved substrate are according to use
The shapes and sizes of the cornea of person are customized.
3. a kind of method for preparing the Corneal electrode described in claim 1 or 2, including following methods one or two:
Method one：
1) graphene is grown on copper foil；
2) PMMA is spun to the side of copper foil growth graphene, then etches away copper foil, obtains the double-deck knot of PMMA/ graphenes
Structure；
3) the PMMA sides of the PMMA/ graphenes double-decker are attached on the convex surface of curved surface quartz glass, obtains graphite
Alkene/PMMA/ quartz glass composite constructions；
4) flexible transparent film is grown on the graphenic surface of the graphene/PMMA/ quartz glass composite constructions, obtained soft
Property transparent membrane/graphene/PMMA/ quartz glass composite constructions；
5) PMMA in the flexible transparent film/graphene/PMMA/ quartz glass composite constructions is removed, so as to by quartz
Glass separates, and obtains flexible transparent film/graphene composite structure；
6) using conductive silver glue the curved surface concave side of flexible transparent film/graphene composite structure marginal position by wire and stone
Black alkene connection, obtains Corneal electrode；
Method two：
A) graphene is grown on the convex side of curved surface quartz glass, obtains graphene/quartz glass composite construction；
B) flexible transparent film is grown in the graphenic surface of the graphene/quartz glass composite construction, obtains flexible and transparent
Film/graphene/quartz glass composite construction；
C) quartz glass in the flexible transparent film/graphene/quartz glass composite construction is removed, it is thin to obtain flexible and transparent
Film/graphene composite structure；
D) using conductive silver glue the curved surface concave side of flexible transparent film/graphene composite structure marginal position by wire and stone
Black alkene connection, obtains Corneal electrode.
4. according to the method for claim 3, it is characterised in that：
In step 1), graphene is grown on copper foil by chemical vapor deposition；
In step 3), the shapes and sizes of the curved surface quartz glass and the shapes and sizes of the curved substrate of target Corneal electrode
Unanimously, it is pre-designed according to the shapes and sizes of the cornea of user；
In step 4), flexibility is grown thoroughly on the surface of graphene/PMMA/ quartz glass composite constructions by chemical vapor deposition
Bright film；
In step 5), removed using acetone solution in flexible transparent film/graphene/PMMA/ quartz glass composite constructions
PMMA, flexible transparent film/graphene is set to be separated with quartz glass.
After step 6), also coating the glue bond position including the use of epoxide-resin glue prevents wire and elargol from directly contacting
The operation of cornea.
5. according to the method for claim 3, it is characterised in that：
In step a), the shapes and sizes of the curved surface quartz glass and the shapes and sizes of the curved substrate of target Corneal electrode
Unanimously, it is pre-designed according to the shapes and sizes of the cornea of user；
Graphene is grown on curved surface quartz glass by chemical vapour deposition technique；
In step b), flexibility is grown by graphenic surface of the chemical vapour deposition technique in graphene/quartz glass composite construction
Transparent membrane；
In step c), by etching the quartzy glass removed in the flexible transparent film/graphene/quartz glass composite construction
Glass, obtain flexible transparent film/graphene composite structure.
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| CN109171709A (en) * | 2018-07-23 | 2019-01-11 | 京东方科技集团股份有限公司 | A kind of dry electrode and preparation method thereof |
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