CN107501254A - The preparation technology of feed addictive vitamin B1 - Google Patents
The preparation technology of feed addictive vitamin B1 Download PDFInfo
- Publication number
- CN107501254A CN107501254A CN201710697089.5A CN201710697089A CN107501254A CN 107501254 A CN107501254 A CN 107501254A CN 201710697089 A CN201710697089 A CN 201710697089A CN 107501254 A CN107501254 A CN 107501254A
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- activated carbon
- vitamin
- stirring
- crude product
- purified water
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D415/00—Heterocyclic compounds containing the thiamine skeleton
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention discloses a kind of preparation technology of feed addictive vitamin B1, includes following steps：（One）It is refined：（1）Once decolourize to feed intake；（2）Secondary decolourization feeds intake；（3）In 5000L enamel reaction stills, purified water is added by the batch once to decolourize, is warming up to 70~80 DEG C, added thiamine hydrochloride crude product, stirring, dissolving, be incubated to 70~80 DEG C, then add activated carbon, thiamine hydrochloride crude product：Purified water：Activated carbon=1:3:0.06, stirring and adsorbing 0.5h, filter cloth filtering, filtrate are transferred in concentration kettle, open steam and concentrate 56 hours, crystallisation by cooling filtering, and crystallization is standby；Vitamin B1, loss on drying≤5.0% of this vitamin B1 is made by using inventive formulation and method, ignition residue≤0.1%, pH is 2.7 3.4, solution color≤0.6ml, sulfate≤0.03%, beneficial to the fully effective absorption of animal, meets requirement.
Description
Technical field
The present invention relates to feed additive field technology, refers in particular to a kind of preparation work of feed addictive vitamin B1
Skill.
Background technology
With the continuous improvement of people's living standards, safety to livestock products and high-quality paying attention to increasingly.Recent study is sent out
The addition effect of existing vitamin is right considerably beyond the category of preventing and treating vitamin-deficiency, vitamin particularly B family vitamin
Played an important role in the synthesis of proteinaceous tissue and the speed of growth of increase body tissue.With the popularization of large-scale cultivation, pig life
Faced in growth process stress factor increase, promote people to think deeply the suitable additive capacity of vitamin in feed again, to up to
The pork product high-quality, safe to production.
The vitamin B1 generally existing loss on drying rate height for animal edible is presently used for, and ignition residue rate is also high,
It is unfavorable for animal absorption, it is impossible to meet requirement.
The content of the invention
In view of this, in view of the existing deficiencies of the prior art, its main purpose is to provide a kind of feed addictive to the present invention
The preparation technology of vitamin B1, it can effectively solve the problems, such as that existing vitamin B1 loss on drying rate and ignition residue are high.
To achieve the above object, the present invention is using following technical scheme：
A kind of preparation technology of feed addictive vitamin B1, includes following steps：
（One）It is refined：
（1）Once decolourize to feed intake：Thiamine hydrochloride crude product 1000kg；Purified water 3000L；Activated carbon 60kg；
（2）Secondary decolourization feeds intake：Once decolouring thiamine hydrochloride crystallization 1000kg；Purified water 3000L；Activated carbon 60kg；
（3）In 5000L enamel reaction stills, purified water is added by the batch once to decolourize, is warming up to 70~80 DEG C, adding salt
Allithiamine crude product, stirring, dissolving, is incubated to 70~80 DEG C, then adds activated carbon, thiamine hydrochloride crude product：Purified water：Activated carbon
=1:3:0.06, stirring and adsorbing 0.5h, filter cloth filtering, filtrate are transferred in concentration kettle, open steam concentration 5-6 hours, crystallisation by cooling
Filtering, crystallization are standby；
In 5000L enamel reaction stills, purified water is added by the batch of secondary decolourization, is warming up to 70~80 DEG C, is being added once
Decolouring thiamine hydrochloride crystallizes, and stirring, dissolving, is incubated to 70~80 DEG C, then adds activated carbon, thiamine hydrochloride crude product：Purified water：
Activated carbon=1:3:0.06, stirring and adsorbing 0.5h, sample examination is qualified, is filtered with filter paper, and filtrate is transferred in crystallization kettle；
（Two）Crystallization：Filtrate is transferred in crystallization kettle, under slow stirring, opens cooling water temperature, is opened when being cooled to 5~15 DEG C
Begin centrifugation, with ethanol wash, dry to obtain wet product；
（Three）Centrifugation and washing：After centrifugation by wet product put into double cone dryer in, by dry post S.O.P. 75 DEG C-
85 DEG C of dry 3-4 hours, it is -0.05~-0.09Mpa to dry vacuum, is recorded once per half an hour, after terminating, steam off
With vacuum；
（Four）Packaging：Dried vitamin B1 is weighed by packing specification requirement, it is close using double-layer polyethylene polybag
Envelope, load in fiber can, it is labelled.
As a kind of preferred scheme, the thiamine hydrochloride crude product is the model Q/ of Xinjiang He Xing Chemical Co., Ltd.s production
XJHX 01-2014 industry crude product aneurin hydrochlorides.
As a kind of preferred scheme, described once to decolourize to feed intake the activated carbon used as needle-use activated carbon, secondary decolourization is thrown
The activated carbon for expecting to use is medicinal carbon.
As a kind of preferred scheme, the step（Two）The speed of middle stirring is 36-40rpm.
The present invention has clear advantage and beneficial effect compared with prior art, specifically, by above-mentioned technical proposal
Understand：
It is residual by using inventive formulation and the obtained vitamin B1 of method, loss on drying≤5.0% of this vitamin B1, calcination
Slag≤0.1%, pH 2.7-3.4, solution color≤0.6ml, sulfate≤0.03%, beneficial to the fully effective absorption of animal, meet
Requirement.
More clearly to illustrate the architectural feature and effect of the present invention, come below in conjunction with the accompanying drawings with specific embodiment to this hair
It is bright to be described in detail.
Brief description of the drawings
Fig. 1 is the Making programme schematic diagram of the preferred embodiments of the invention.
Embodiment
It refer to shown in Fig. 1, that show the Making programme of the preferred embodiments of the invention, include following steps：
（One）It is refined：
（1）Once decolourize to feed intake：Thiamine hydrochloride crude product 1000kg；Purified water 3000L；Activated carbon 60kg；In the present embodiment
In, the thiamine hydrochloride crude product is the model Q/XJHX 01-2014 industry crude products of Xinjiang He Xing Chemical Co., Ltd.s production
Aneurin hydrochloride；Once decolourize to feed intake the activated carbon used as needle-use activated carbon.
（2）Secondary decolourization feeds intake：Once decolouring thiamine hydrochloride crystallization 1000kg；Purified water 3000L；Activated carbon 60kg；
In the present embodiment, secondary decolourization feeds intake the activated carbon used as medicinal carbon.
（3）In 5000L enamel reaction stills, purified water is added by the batch once to decolourize, 70~80 DEG C is warming up to, is adding
Enter thiamine hydrochloride crude product, stirring, dissolving, be incubated to 70~80 DEG C, then add activated carbon, thiamine hydrochloride crude product：Purified water：It is living
Property charcoal=1:3:0.06, stirring and adsorbing 0.5h, filter cloth filtering, filtrate are transferred in concentration kettle, open steam concentration 5-6 hours, cooling
Crystallization filtering, crystallization are standby.
In 5000L enamel reaction stills, purified water is added by the batch of secondary decolourization, 70~80 DEG C is warming up to, is adding
Once decolouring thiamine hydrochloride crystallizes, and stirring, dissolving, is incubated to 70~80 DEG C, then adds activated carbon, thiamine hydrochloride crude product：It is pure
Change water：Activated carbon=1:3:0.06, stirring and adsorbing 0.5h, sample examination is qualified, is filtered with filter paper, and filtrate is transferred in crystallization kettle.
（Two）Crystallization：Filtrate is transferred in crystallization kettle, under slow stirring, opens cooling water temperature, is cooled to 5~15 DEG C
When start to centrifuge, with ethanol wash, dry to obtain wet product；The speed of stirring is 36-40rpm.
（Three）Centrifugation and washing：Wet product is put into double cone dryer after centrifugation, existed by post S.O.P. is dried
75 DEG C -85 DEG C dry 3-4 hours, it is -0.05~-0.09Mpa to dry vacuum, and per half an hour, record once, after terminating, is closed
Steam and vacuum；
（Four）Packaging：Dried vitamin B1 is weighed by packing specification requirement, it is close using double-layer polyethylene polybag
Envelope, load in fiber can, it is labelled.
The vitamin B1 that above-mentioned technique is prepared is used to have faint special smell, taste for white crystals or crystalline powder
Hardship, soluble in water, ethanol, insoluble in ether, dry product immediately absorbs about 4% moisture in air weight.
After tested, loss on drying≤5.0% of this product, ignition residue≤0.1%, pH 2.7-3.4, solution color≤
0.6ml, sulfate≤0.03%.
The above described is only a preferred embodiment of the present invention, be not intended to limit the scope of the present invention,
Therefore any subtle modifications, equivalent variations and modifications that every technical spirit according to the present invention is made to above example, still
Belong in the range of technical solution of the present invention.
Claims (4)
- A kind of 1. preparation technology of feed addictive vitamin B1, it is characterised in that：Include following steps：（One）It is refined：（1）Once decolourize to feed intake：Thiamine hydrochloride crude product 1000kg；Purified water 3000L；Activated carbon 60kg；（2）Secondary decolourization feeds intake：Once decolouring thiamine hydrochloride crystallization 1000kg；Purified water 3000L；Activated carbon 60kg；（3）In 5000L enamel reaction stills, purified water is added by the batch once to decolourize, is warming up to 70~80 DEG C, adding salt Allithiamine crude product, stirring, dissolving, is incubated to 70~80 DEG C, then adds activated carbon, thiamine hydrochloride crude product：Purified water：Activated carbon =1:3:0.06, stirring and adsorbing 0.5h, filter cloth filtering, filtrate are transferred in concentration kettle, open steam concentration 5-6 hours, crystallisation by cooling Filtering, crystallization are standby；In 5000L enamel reaction stills, purified water is added by the batch of secondary decolourization, is warming up to 70~80 DEG C, is being added once Decolouring thiamine hydrochloride crystallizes, and stirring, dissolving, is incubated to 70~80 DEG C, then adds activated carbon, thiamine hydrochloride crude product：Purified water： Activated carbon=1:3:0.06, stirring and adsorbing 0.5h, sample examination is qualified, is filtered with filter paper, and filtrate is transferred in crystallization kettle；（Two）Crystallization：Filtrate is transferred in crystallization kettle, under slow stirring, opens cooling water temperature, is opened when being cooled to 5~15 DEG C Begin centrifugation, with ethanol wash, dry to obtain wet product；（Three）Centrifugation and washing：After centrifugation by wet product put into double cone dryer in, by dry post S.O.P. 75 DEG C- 85 DEG C of dry 3-4 hours, it is -0.05~-0.09Mpa to dry vacuum, is recorded once per half an hour, after terminating, steam off With vacuum；（Four）Packaging：Dried vitamin B1 is weighed by packing specification requirement, it is close using double-layer polyethylene polybag Envelope, load in fiber can, it is labelled.
- 2. the preparation technology of feed addictive vitamin B1 according to claim 1, it is characterised in that：The thiamine hydrochloride Crude product is the model Q/XJHX 01-2014 industry crude product aneurin hydrochlorides of Xinjiang He Xing Chemical Co., Ltd.s production.
- 3. the preparation technology of feed addictive vitamin B1 according to claim 1, it is characterised in that：It is described once to decolourize The activated carbon used feed intake as needle-use activated carbon, secondary decolourization feeds intake the activated carbon used as medicinal carbon.
- 4. the preparation technology of feed addictive vitamin B1 according to claim 1, it is characterised in that：The step（Two） The speed of middle stirring is 36-40rpm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710697089.5A CN107501254A (en) | 2017-08-15 | 2017-08-15 | The preparation technology of feed addictive vitamin B1 |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710697089.5A CN107501254A (en) | 2017-08-15 | 2017-08-15 | The preparation technology of feed addictive vitamin B1 |
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| CN107501254A true CN107501254A (en) | 2017-12-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710697089.5A Pending CN107501254A (en) | 2017-08-15 | 2017-08-15 | The preparation technology of feed addictive vitamin B1 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111087393A (en) * | 2019-12-30 | 2020-05-01 | 江苏兄弟维生素有限公司 | Thiamine hydrochloride, drying method and application thereof, and vitamin B1 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE55626B1 (en) * | 1982-06-24 | 1990-12-05 | Stoppani Luigi Spa | Adduct of mutually stabilizing menadione and thiamine |
| CN1459449A (en) * | 2002-05-22 | 2003-12-03 | 东北制药总厂 | New method of preparing ritamin B1 hydrochloride using thiohydrothiamine |
| CN104031038A (en) * | 2014-07-04 | 2014-09-10 | 东北制药集团股份有限公司 | Method for preparing vitamin B1 hydrochloride with thiol thiamine |
| CN104817551A (en) * | 2015-05-07 | 2015-08-05 | 常州大学 | New method of preparing vitamin B1 hydrochloride |
-
2017
- 2017-08-15 CN CN201710697089.5A patent/CN107501254A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE55626B1 (en) * | 1982-06-24 | 1990-12-05 | Stoppani Luigi Spa | Adduct of mutually stabilizing menadione and thiamine |
| CN1459449A (en) * | 2002-05-22 | 2003-12-03 | 东北制药总厂 | New method of preparing ritamin B1 hydrochloride using thiohydrothiamine |
| CN104031038A (en) * | 2014-07-04 | 2014-09-10 | 东北制药集团股份有限公司 | Method for preparing vitamin B1 hydrochloride with thiol thiamine |
| CN104817551A (en) * | 2015-05-07 | 2015-08-05 | 常州大学 | New method of preparing vitamin B1 hydrochloride |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111087393A (en) * | 2019-12-30 | 2020-05-01 | 江苏兄弟维生素有限公司 | Thiamine hydrochloride, drying method and application thereof, and vitamin B1 |
| CN111087393B (en) * | 2019-12-30 | 2021-11-23 | 江苏兄弟维生素有限公司 | Thiamine hydrochloride, drying method and application thereof, and vitamin B1 |
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| PB01 | Publication | ||
| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
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Application publication date: 20171222 |