CN107496982A - Promote the derivative doctor's material and its preparation method of impaired bone repair and capillary proliferation - Google Patents
Promote the derivative doctor's material and its preparation method of impaired bone repair and capillary proliferation Download PDFInfo
- Publication number
- CN107496982A CN107496982A CN201610413669.2A CN201610413669A CN107496982A CN 107496982 A CN107496982 A CN 107496982A CN 201610413669 A CN201610413669 A CN 201610413669A CN 107496982 A CN107496982 A CN 107496982A
- Authority
- CN
- China
- Prior art keywords
- bone
- glue
- derivative
- calcium phosphorus
- promotion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses
Abstract
Promoting alveolar bone, impaired sclerotin, at Cranial defect and derivative doctor's material of capillary proliferation and its preparation method the invention discloses a kind of, it includes the mixture of artificial calcium phosphorus kind bone meal and glue, wherein：Artificial calcium phosphorus kind bone meal has irregular shape loose structure, and loose structure part is connected；Glue is made by degradable macromolecule, and glue includes cellular structure；The volume ratio that artificial calcium phosphorus kind bone meal mixes with glue is 1：1 to 3：1.The present invention provides alveolar bone, impaired sclerotin, at Cranial defect with microvascular tissue hyperplasia, promote teeth groove Bone Defect Repari, the alveolar bone of preferable bone density and thickness be subsequently generated with profit, contributes to implantable artificial root of the tooth；Accelerate impaired bone tissue growth, to recover the integrality of bone and feature.
Description
Technical field
On promote alveolar bone, impaired sclerotin, at Cranial defect and capillary proliferation derivative doctor's material and its preparation method, use
Carry out repairing bone defect, to recover the integrality and feature of impaired bone, establish adequate thickness, the alveolar bone of density in favor of people
Work dental implant surgical.
Background technology
Traditional Man plants the operation of tooth, is sclerotin in the oral cavity（Alveolar bone）The artificial tooth root of upper implantation titanium,
Need to fill bone meal if excessive at alveolar bone thickness deficiency or Cranial defect, then by the bone growth process of 3 to 6 months, treat
After the completion of bone growth, replant into artificial tooth root, then wait alveolar bone to be combined closely with artificial tooth root, artificial tooth in square set（Metal
Or ceramic corona）It is fixed.
The artificial bone meal used now is not derived from true man's bone, is derived from the freeze-drying bone meal of people's bone and sufficiently expensive, disease
Trouble often is difficult to bear, so now more bone meal products synthesized by using chemistry, but it is maximum the shortcomings that be that the generation of sclerotin is imitated
Fruit, the bone meal inserted are difficult the bone that is absorbed by the body and is converted into completely.Early stage bone meal rule of origin is taken from ox bone or coral more
Coral, there is artificial bone meal and foregoing mentioned people's bone bone meal now, no matter but be derived from the bone meal of animal or human body, former place need to be undertaken
It is main to have the risk for infecting disease or unknown hiding bacterium and virus, so the major part used at present is artificial synthesized bone meal.
Bone meal, which induces teeth groove bone uptake, to wait as long for, and treat that its bone density reaches certain standard ability replantation tooth, process much time
Power, and have often because bone meal stability is not enough lost in, it is unable to reach regeneration effect.Therefore merely using bone meal as alveolar bone
Regeneration using effect has its weak point.
It is impaired with defect, being come more using the Dutchman of bone pureed at filling bone defects for large range of sclerotin, according to
Region difference is filled up, high score subclass bone mud or calcium phosphorus kind bone mud product can be selected, but high score subclass product human body can not absorb,
Can be always in body；And calcium phosphorus kind bone mud is then to have that asking for bone can not be fully absorbed and be converted into by human body as bone meal
Topic, therefore merely using calcium phosphorus kind bone mud as the Dutchman for filling up Cranial defect, it promotes bone regeneration effect to have its deficiency
Place.
The content of the invention
In order to solve the above-mentioned technical problem, the invention provides one kind promote alveolar bone, impaired sclerotin, at Cranial defect with it is micro-
Derivative doctor's material and its preparation method of blood vessel hyperplasia.
It is provided by the invention promote alveolar bone, impaired sclerotin, at Cranial defect and capillary proliferation derivative doctor's material, it includes
The mixture of artificial calcium phosphorus kind bone meal and glue, it is characterised in that：
Artificial calcium phosphorus kind bone meal has irregular shape loose structure, and loose structure part is connected；Glue is degradable high score
Made by son, and glue includes cellular structure；The volume ratio that artificial calcium phosphorus kind bone meal mixes with glue is 1：1 to 3：1.
Preferably, artificial calcium phosphorus kind bone meal burns after being mixed by tetracalcium phosphate, Dicalcium Phosphate, perforating agent with curing agent through high temperature
Knot is made；Manually 100 μm to 500 μm of its aperture size of the loose structure of calcium phosphorus kind bone meal.
Preferably, the preparation method of the glue is：Sodium alginate, gelatin, hyaluronic acid, spherical chitosan or gucosamine
Grain size 2mm to 5mm particle is made with crosslinking agent for two or more combinations in high-hydroscopicity glue, is in solvent cast separately
Porous surface kenel and interconnected loose structure.
Preferably, perforating agent is the esters of soluble carbohydrate, salt or sinterable volatilization, and curing agent uses phosphoric acid water
Solution.
Preferably, derivative doctor's material further comprises having reconstruction proteosome and is attached to glue surface and internal porosity
Structure, rebuild proteosome and include the first collagen type, the second collagen type, sericin, fibroin albumen, Bones morphology hair
Raw albumen or phosphatldylcholine.
Preferably, further in the autologous extraction blood of derivative doctor's material surface attachment or autologous extraction blood platelet.
The present invention also provide it is a kind of promote alveolar bone, impaired sclerotin, at Cranial defect and capillary proliferation derivative doctor's material, its
Mixture including artificial calcium phosphorus kind bone mud and glue,
Glue is made by degradable macromolecule, and glue includes cellular structure；Artificial calcium phosphorus kind bone mud and glue mixing ratio
Example is 1：1 to 3：1.
Preferably, artificial calcium phosphorus kind bone mud is mixed to prepare by tetracalcium phosphate, Dicalcium Phosphate and curing agent, and curing agent uses
Phosphate aqueous solution.
Preferably, glue includes sodium alginate, gelatin, hyaluronic acid, spherical chitosan or gucosamine high-hydroscopicity water
Glue, and grain size 2mm to 5mm particle is made up of two or more glue and crosslinking agent, it is in separately Surface porous with solvent cast
State and interconnected loose structure.
Preferably, derivative doctor's material further comprises having reconstruction proteosome and is attached to glue surface and internal porosity
Structure, rebuild proteosome and include the first collagen type, the second collagen type, sericin, fibroin albumen, Bones morphology hair
Raw albumen or phosphatldylcholine.
Preferably, further in the autologous extraction blood of derivative doctor's material surface attachment or autologous extraction blood platelet.
The present invention, which provides, a kind of to be promoted alveolar bone, impaired sclerotin, is made with derivative doctor's material of capillary proliferation at Cranial defect
Method, including：
Manufacturing artificial calcium phosphorus kind bone meal step, through high temperature sintering after being mixed by tetracalcium phosphate, Dicalcium Phosphate, perforating agent with curing agent
It is made；
Glue step is made, is made up of sodium alginate and gelatin with crosslinking agent, and into porous surface and is connected with solvent cast,
The glue that grain size is 2mm to 5mm is made；
Grinding and sifting step, grind artificial calcium phosphorus kind bone meal and take particle diameter between 0.5mm to 5mm particle by screening；
Blend step, artificial calcium phosphorus kind bone meal and glue are with ratio 1：1 to 3：1 mixing.
Preferably, the reconstruction proteosome attachment steps for having after glue step is made are further comprised, wherein rebuilding albumen
Body is attached to glue surface and internal porosity structure, rebuilds proteosome and includes the first collagen type, the second Collagen Type VI egg
In vain, sericin, fibroin albumen, bone morphogenetic protein or phosphatldylcholine.
Preferably, further comprise there are the attachment steps after blend step, it is autologous in derivative doctor's material surface attachment
Extract blood or autologous extraction blood platelet.
The present invention also provide it is a kind of promote alveolar bone, impaired sclerotin, at Cranial defect and capillary proliferation derivative doctor's material system
Make method, including：
Manufacturing artificial calcium phosphorus kind bone mud step, is made by tetracalcium phosphate and Dicalcium Phosphate；
Glue step is made, is made up of sodium alginate and gelatin with crosslinking agent, and into porous surface and is connected with solvent cast,
Grain size 2mm to 5mm glue is made；
Blend step, take artificial calcium phosphorus kind bone mud first to be mixed with curing agent, add glue, artificial calcium phosphorus kind bone meal and glue with
Ratio 1：1 to 3：Mixed between 1.
Preferably, the reconstruction proteosome attachment steps for having after glue step is made are further comprised, wherein rebuilding albumen
Body is attached to glue surface and internal porosity structure, rebuilds proteosome and includes the first collagen type, the second Collagen Type VI egg
In vain, sericin, fibroin albumen, bone morphogenetic protein or phosphatldylcholine.
Preferably, further comprise there are the attachment steps after blend step, it is autologous in derivative doctor's material surface attachment
Extract blood or autologous extraction blood platelet.
The present invention provides alveolar bone, impaired sclerotin, at Cranial defect with microvascular tissue hyperplasia, promote teeth groove Bone Defect Repari, with
Profit is subsequently generated the alveolar bone of preferable bone density and thickness, contributes to implantable artificial root of the tooth；Accelerate impaired bone tissue growth, with
Recover the integrality and feature of bone.
Brief description of the drawings
Fig. 1 is that doctor's material of the invention containing artificial calcium phosphorus kind bone meal is implanted in schematic diagram at teeth groove Cranial defect.
Fig. 2 is that doctor's material of the invention containing artificial calcium phosphorus kind bone mud is implanted in schematic diagram at teeth groove Cranial defect.
Fig. 3 is doctor's material of the invention containing artificial calcium phosphorus kind bone mud with respect to schematic diagram before alveolar bone, capilary effect.
Fig. 4 is relative Fig. 3 glues localized degradation and discharges reconstruction proteosome schematic diagram.
Fig. 5 is relative Fig. 4 glues degraded trend scope, and osteoclast and osteoblast are divided a word with a hyphen at the end of a line schematic diagram.
Fig. 6 is to carry out bone information and osteoblast to bone meal with respect to Fig. 5 osteoclasts to secrete bone matrix, mineralising schematic diagram.
Fig. 7 is derivative doctor material preparation method flow chart of the present invention containing artificial calcium phosphorus kind bone meal.
Fig. 8 is derivative doctor material preparation method flow chart of the present invention containing artificial calcium phosphorus kind bone mud.
【Primary clustering symbol description】
1 doctor's material；11 artificial calcium phosphorus kind bone meal；
12 glues；121 cellular structures；
13 rebuild proteosome；
2 alveolar bones；21 osteoclasts；
22 osteoblasts；23 capilaries；
3 gingival soft tissues.
Embodiment
The invention will be further described with specific embodiment below in conjunction with the accompanying drawings, so that those skilled in the art can be with
It is better understood from the present invention and can be practiced, but illustrated embodiment is not as a limitation of the invention.
Refer to shown in schema Fig. 1, the present invention is disclosed in figure and promotes alveolar bone, impaired sclerotin, at Cranial defect and capilary
Derivative doctor's material 1 of hyperplasia is positioned at the defect of alveolar bone 2, includes the mixture of artificial calcium phosphorus kind bone meal 11 and glue 12, its
In；The artificial surface of calcium phosphorus kind bone meal 11 has irregular shape loose structure, and loose structure part is connected；Glue 12 is by that can drop
Solve made by macromolecule, and glue 12 includes cellular structure 121；The volume ratio that artificial calcium phosphorus kind bone meal 11 mixes with glue 12
Example is 1:1 to 3:1.
The foregoing embodiment of doctor's material 1 can also use artificial Phosphorus bone mud 10 to coordinate glue using artificial calcium phosphorus kind bone meal
Coordinate doctor material 1 of the glue 12 as another kenel, such as shown in Fig. 2, it includes artificial calcium phosphorus kind bone mud 10 and glue 12
Mixture, wherein：Glue 12 is as made by degradable macromolecule, and glue 12 includes cellular structure 121；Artificial calcium phosphorus kind bone
The volume ratio that mud 10 mixes with glue 12 is 1:1 to 3:1.
Foregoing artificial calcium phosphorus kind bone meal 11 through high temperature sintering by being made tetracalcium phosphate（TTCP）, Dicalcium Phosphate（DCPA）, system
Hole agent is mixed to prepare with curing agent；Its aperture size of the loose structure of artificial calcium phosphorus kind bone meal 11 is 100 μm to 500 μm again.Before
State tetracalcium phosphate（TTCP）By calcium carbonate (CaCO3)With calcium pyrophosphate (Ca2P2O7) be made through 1400 DEG C of high temperature sinterings.
And foregoing artificial calcium phosphorus kind bone mud 10 is by tetracalcium phosphate（TTCP）, Dicalcium Phosphate（DCPA）System is mixed with curing agent
, and curing agent adopts phosphate aqueous solution.
Foregoing perforating agent is the esters of soluble carbohydrate, salt or sinterable volatilization, and curing agent adopts phosphate aqueous solution.
Foregoing glue 12 includes sodium alginate（sodium alginate）, gelatin（gelatin）, hyaluronic acid
(hyaluronan), spherical chitosan（chitosan）Or gucosamine（glucosamine）High-hydroscopicity glue, and by 2 kinds with
Grain size 2mm to 5mm is made in upper glue 12 and crosslinking agent, separately with solvent cast in porous surface kenel and interconnected more
Pore structure.
Doctor's material 1, which further comprises having, to be rebuild proteosome 13 and is attached to glue surface and internal porosity structure, rebuilds egg
Lean type 13 includes sericin（sericin）, fibroin albumen（Fibroin）, bone morphogenetic protein (bone
Morphogenetic protein) or phosphatldylcholine (Phosphatidylcholine).It is or further attached in doctor's material 1 surface
Autologous extraction blood or autologous extraction blood platelet, foregoing attachment blood or blood platelet can be attached to doctor's material 1 using immersion way.
Then referred to shown in schema Fig. 1 on occupation mode of the present invention, gingival soft tissue 3 shown in figure to cut in advance,
And there is pothole phenomenon the atrophy of emulated gum soft tissue 3 and the middle position of alveolar bone 2（The thickness of alveolar bone 2 is excessively thin herein）, incite somebody to action this
Invention doctor's material 1 is implanted into pothole position, rear then suture implantation and cure gingival soft tissue 3 above the position of material 1.And Fig. 2 institutes of the present invention
Show, be then that will cure the top position of capilary 23 that material 1 is positioned over the excessively thin and close larger caliber size of the thickness of alveolar bone 2.
Referring to Fig. 3 and 4 again, Fig. 3 is the enlarged diagram that will be cured material 1 and be implanted at teeth groove damaged bone or Cranial defect, and
Illustrated herein exemplified by coordinating glue 12 using artificial calcium phosphorus kind bone mud 10.And Fig. 4 simulates the glue of the closer lower section of alveolar bone 2
12 are gradually degraded, and have and the state of proteosome 13 of rebuilding is discharged from glue 12, and Fig. 5, which is then shown below script Fig. 4, glue 12
Degraded finishes to form the larger state of hole 120.
And Fig. 5 shows that the degraded of glue 12 except showing the close lower section of alveolar bone 2 forms hole 120 and has gradual upward model
Enclose outside degraded trend, the osteoclast emulated by the middle position of alveolar bone 2（osteoclast）21, and right positions
Osteoblast (osteoblast) 22 moves towards doctor's material 1 position, direction, osteoclast（osteoclast）21 and osteoblast
(osteoblast) arrow indicates in 22 moving direction such as schema.
Fig. 6 then emulates capilary 23 gradual upward, expansion new life of the display script positioned at alveolar bone 2（Angiogenesis
Angiogenesis；Derived by original blood vessel（Bud natural disposition (Sprouting)）, and enter and be degraded by script glue 12
Hole 120 derive, and osteoclast 21 is to artificial calcium phosphorus kind bone mud 10（Artificial calcium phosphorus kind bone meal 11 can equally reach by breaking
Osteocyte exercises bone information）Exercise bone information（bone resorption）Function（As schema osteoclast 21 is attached to hole
Shown in surrounding, can also bone information be carried out to the surface of alveolar bone 2 certainly；Secreting acidic material dissolved mineral, extracellular proteinase disappear
Change bone matrix, form Bone resoiption pit）, osteoblast 22 (osteoblast) then travelled to close to former alveolar bone 2 and foregoing
By 21 absorption sites of osteoclast secretion bone matrixs, bone matrix mineralising and form new bone.
By foregoing a series of effect, artificial calcium phosphorus kind bone mud 10 is mixed using glue 12, people can be increased considerably
The combination stability of work calcium phosphorus kind bone mud 10, until glue 12 to form hole 120 and be more conducive to capilary with being gradually degraded
23 have space to derive, and the hole of artificial calcium phosphorus kind bone mud 10 can then lure osteoclast into（osteoclast）21 divide a word with a hyphen at the end of a line it is attached
Enforcement bone resorption, and with osteoclast（osteoclast）21 in active effect herein, and then promotes to attract into making bone
Cell (osteoblast) 22 travels to around secretion bone matrix, mineralising and forms new bone in pothole position then, effectively facilitates tooth
Groove bone 2, which is rebuild, to be increased, and reaches the purpose of the present invention and effect accordingly.In addition, promote the hyperplasia of alveolar bone 2 by proteosome 13 is rebuild
Derive with capilary 23, be thusly-formed dual teeth groove bone regeneration benefit.
It must illustrate, since the effectiveness of Cranial defect hyperplasia can be provided by the foregoing artificial calcium phosphorus kind bone mud 10 of explanation,
And artificial calcium phosphorus kind bone meal 11 equally has identical composition tetracalcium phosphate using with artificial calcium phosphorus kind bone mud 10（TTCP）, Dicalcium Phosphate
（DCPA）, can also have the function that same as before and effect.
Refer to shown in Fig. 7, promote teeth groove bone regeneration to derive doctor's material preparation method with capilary, including：Promotion alveolar bone,
Material preparation method is cured with the derivative of capillary proliferation at impaired sclerotin, Cranial defect, including：Manufacturing artificial calcium phosphorus kind bone meal step,
By tetracalcium phosphate（TTCP）, Dicalcium Phosphate（DCPA）, perforating agent and curing agent be mixed to prepare, and be made through high temperature sintering；Make
Glue step, by sodium alginate（sodium alginate）And gelatin（gelatin）It is made with crosslinking agent, and with solvent cast
Into porous surface and it is connected, grain size 2mm is made to 5mm glues；Grinding and sifting step, grind artificial calcium phosphorus kind bone meal
And particle diameter is taken between 0.5mm to 5mm by screening；Blend step, artificial calcium phosphorus kind bone meal and glue are with ratio 1：1 to 3：Between 1
Mixing.
Further comprise the reconstruction proteosome attachment steps for having after glue step is made, be attached to wherein rebuilding proteosome
Glue surface and internal porosity structure, rebuild proteosome and include sericin（sericin）, fibroin albumen（Fibroin）、
Bone morphogenetic protein (bone morphogenetic protein) or phosphatldylcholine (Phosphatidylcholine).
Further comprise having the attachment steps after blend step, extract blood or autologous take out in doctor's material surface attachment is autologous
Take blood platelet.10cc to 60cc venous blood blood can be extracted from patient's elbow portion by autologous extraction blood or the autologous blood platelet that extracts
Liquid.And after being handled further across centrifuge, separation obtains the PRF of g., jelly-like（Rich in hematoblastic fibrin）；By certainly
Body intra platelet free calcium growth hormone, can make soft tissue Fast Growth, reach wound healing, and using platelet-derived growth hormone as
Teeth groove bone inductive effect, vascular endothelial growth hormone promote endothelial cells secrete BMP-2（Strong bone gemmule proliferant agent）, accelerate
Teeth groove osseous maturation.And using autoblood or autologous platelet be autologous patient product, without immunizing antigen, antibody problem,
There is sizable help to anti-infective and immunological regulation for Post operation.In addition, using self-blood or itself blood platelet its PH
It is worth meta-alkali and is not suitable for bacterial growth, also containing high dose white blood cell, there is the function of eliminating thin mattress, promotes alveolar bone and gum soft
Function of tissue regeneration.
In addition, on using artificial calcium phosphorus kind bone meal, both artificial calcium phosphorus kind bone mud doctor's material preparation method then respectively such as
Shown in following：
One of which promote alveolar bone, impaired sclerotin, at Cranial defect and capillary proliferation derivative doctor's material preparation method, including：
Manufacturing artificial calcium phosphorus kind bone meal step, by tetracalcium phosphate（TTCP）, Dicalcium Phosphate（DCPA）, perforating agent mixed with curing agent, and
It is made through high temperature sintering；Glue step is made, by sodium alginate（sodium alginate）And gelatin（gelatin）With crosslinking
Agent is made, and into porous surface and is connected with solvent cast, and grain size 2mm is made to 5mm glues；Grinding walks with sieving
Suddenly, grind artificial calcium phosphorus kind bone meal and take particle diameter between 0.5mm to 5mm by screening；Blend step, artificial calcium phosphorus kind bone meal with
Glue is with ratio 1:1 to 3:Mixed between 1.
Another kind promote alveolar bone, impaired sclerotin, at Cranial defect and capillary proliferation derivative doctor's material preparation method, bag
Include：Manufacturing artificial calcium phosphorus kind bone mud step, by tetracalcium phosphate（TTCP）, Dicalcium Phosphate（DCPA）It is made；Glue step is made, by
Sodium alginate（sodium alginate）And gelatin（gelatin）Be made with crosslinking agent, and with solvent cast into porous surface simultaneously
It is connected, grain size 2mm is made to 5mm glues；Blend step, take artificial calcium phosphorus kind bone mud first to be mixed with curing agent, then add
Enter glue, artificial calcium phosphorus kind bone meal and glue are with ratio 1:1 to 3:Mixed between 1.
It should be noted that further comprise the reconstruction proteosome attachment steps for having after glue step is made, wherein heavy
Build proteosome and be attached to glue surface and internal porosity structure, rebuild proteosome and include the first collagen type (type I
Collagen), the second collagen type (type II Collagen), sericin（sericin）, fibroin albumen
（Fibroin）, bone morphogenetic protein (bone morphogenetic protein) or phosphatldylcholine
(Phosphatidylcholine).Even further comprise having the attachment steps after blend step, in doctor's material surface attachment certainly
Body extracts blood or autologous extraction blood platelet.
Embodiment described above is only to absolutely prove preferred embodiment that is of the invention and being lifted, protection model of the invention
Enclose not limited to this.The equivalent substitute or conversion that those skilled in the art are made on the basis of the present invention, in the present invention
Protection domain within.Protection scope of the present invention is defined by claims.
Claims (17)
1. at a kind of promotion alveolar bone, impaired sclerotin, Cranial defect and the derivative of capillary proliferation cures material, it includes artificial calcium phosphorus kind
The mixture of bone meal and glue, it is characterised in that：
Artificial calcium phosphorus kind bone meal has irregular shape loose structure, and loose structure part is connected；Glue is degradable high score
Made by son, and glue includes cellular structure；The volume ratio that artificial calcium phosphorus kind bone meal mixes with glue is 1：1 to 3：1.
2. at promotion alveolar bone as claimed in claim 1, impaired sclerotin, Cranial defect and the derivative of capillary proliferation cures material, its
Be characterised by, artificial calcium phosphorus kind bone meal mixed by tetracalcium phosphate, Dicalcium Phosphate, perforating agent with curing agent after through high temperature sintering system
；Manually 100 μm to 500 μm of its aperture size of the loose structure of calcium phosphorus kind bone meal.
3. at promotion alveolar bone as claimed in claim 2, impaired sclerotin, Cranial defect and the derivative of capillary proliferation cures material, its
It is characterised by, the preparation method of the glue is：Sodium alginate, gelatin, hyaluronic acid, spherical chitosan or gucosamine high water absorption
Property glue in two or more combinations and crosslinking agent grain size 2mm to 5mm particle is made, it is separately more in surface with solvent cast
Pass state and interconnected loose structure.
4. at promotion alveolar bone as claimed in claim 3, impaired sclerotin, Cranial defect and the derivative of capillary proliferation cures material, its
It is characterised by, perforating agent is the esters of soluble carbohydrate, salt or sinterable volatilization, and curing agent uses phosphate aqueous solution.
5. as at the promotion alveolar bone any one of Claims 1-4, impaired sclerotin, Cranial defect and capillary proliferation
It is derivative to cure material, it is characterised in that derivative doctor's material further comprises having reconstruction proteosome and is attached to glue surface and inside
Cellular structure, rebuild proteosome and include the first collagen type, the second collagen type, sericin, fibroin albumen, bone
Morphogenetic proteins or phosphatldylcholine.
6. at promotion alveolar bone as claimed in claim 5, impaired sclerotin, Cranial defect and the derivative of capillary proliferation cures material, its
It is characterised by, further in the autologous extraction blood of doctor's material surface attachment or autologous extraction blood platelet.
7. at a kind of promotion alveolar bone, impaired sclerotin, Cranial defect and the derivative of capillary proliferation cures material, it includes artificial calcium phosphorus kind
The mixture of bone mud and glue, it is characterised in that
Glue is made by degradable macromolecule, and glue includes cellular structure；Artificial calcium phosphorus kind bone mud and glue mixing ratio
Example is 1：1 to 3：1.
8. at promotion alveolar bone as claimed in claim 7, impaired sclerotin, Cranial defect and the derivative of capillary proliferation cures material, its
It is characterised by, artificial calcium phosphorus kind bone mud is mixed to prepare by tetracalcium phosphate, Dicalcium Phosphate and curing agent, and curing agent uses phosphoric acid water
Solution.
9. at promotion alveolar bone as claimed in claim 8, impaired sclerotin, Cranial defect and the derivative of capillary proliferation cures material, its
It is characterised by, glue includes sodium alginate, gelatin, hyaluronic acid, spherical chitosan or gucosamine high-hydroscopicity glue, and by
Grain size 2mm to 5mm particle is made with crosslinking agent for two or more glue, is in separately porous surface kenel and phase with solvent cast
Intercommunicated loose structure.
10. at the promotion alveolar bone, impaired sclerotin, Cranial defect as any one of claim 7 to 9 and capillary proliferation
It is derivative to cure material, it is characterised in that derivative doctor's material further comprises having reconstruction proteosome and is attached to glue surface and inside
Cellular structure, rebuild proteosome and include the first collagen type, the second collagen type, sericin, fibroin albumen, bone
Morphogenetic proteins or phosphatldylcholine.
11. at promotion alveolar bone as claimed in claim 10, impaired sclerotin, Cranial defect and the derivative of capillary proliferation cures material,
Characterized in that, further in the autologous extraction blood of derivative doctor's material surface attachment or autologous extraction blood platelet.
12. at a kind of promotion alveolar bone, impaired sclerotin, Cranial defect and the derivative of capillary proliferation cures material preparation method, its feature
It is, including：
Manufacturing artificial calcium phosphorus kind bone meal step, through high temperature sintering after being mixed by tetracalcium phosphate, Dicalcium Phosphate, perforating agent with curing agent
It is made；
Glue step is made, is made up of sodium alginate and gelatin with crosslinking agent, and into porous surface and is connected with solvent cast,
The glue that grain size is 2mm to 5mm is made；
Grinding and sifting step, grind artificial calcium phosphorus kind bone meal and take particle diameter between 0.5mm to 5mm particle by screening；
Blend step, artificial calcium phosphorus kind bone meal and glue are with ratio 1：1 to 3：1 mixing.
13. at promotion alveolar bone as claimed in claim 12, impaired sclerotin, Cranial defect and the derivative of capillary proliferation cures material system
Make method, it is characterised in that further comprise the reconstruction proteosome attachment steps for having after glue step is made, wherein rebuilding egg
Lean type is attached to glue surface and internal porosity structure, rebuilds proteosome and includes the first collagen type, the second Collagen Type VI
Albumen, sericin, fibroin albumen, bone morphogenetic protein or phosphatldylcholine.
14. at promotion alveolar bone as claimed in claim 13, impaired sclerotin, Cranial defect and the derivative of capillary proliferation cures material system
Make method, it is characterised in that further comprise having the attachment steps after blend step, in derivative doctor's material surface attachment certainly
Body extracts blood or autologous extraction blood platelet.
15. at a kind of promotion alveolar bone, impaired sclerotin, Cranial defect and the derivative of capillary proliferation cures material preparation method, its feature
It is, including：
Manufacturing artificial calcium phosphorus kind bone mud step, is made by tetracalcium phosphate and Dicalcium Phosphate；
Glue step is made, is made up of sodium alginate and gelatin with crosslinking agent, and into porous surface and is connected with solvent cast,
Grain size 2mm to 5mm glue is made；
Blend step, take artificial calcium phosphorus kind bone mud first to be mixed with curing agent, add glue, artificial calcium phosphorus kind bone meal and glue with
Ratio 1：1 to 3：Mixed between 1.
16. at promotion alveolar bone as claimed in claim 15, impaired sclerotin, Cranial defect and the derivative of capillary proliferation cures material system
Make method, it is characterised in that further comprise the reconstruction proteosome attachment steps for having after glue step is made, wherein rebuilding egg
Lean type is attached to glue surface and internal porosity structure, rebuilds proteosome and includes the first collagen type, the second Collagen Type VI
Albumen, sericin, fibroin albumen, bone morphogenetic protein or phosphatldylcholine.
17. at promotion alveolar bone as claimed in claim 16, impaired sclerotin, Cranial defect and the derivative of capillary proliferation cures material system
Make method, it is characterised in that further comprise having the attachment steps after blend step, in derivative doctor's material surface attachment certainly
Body extracts blood or autologous extraction blood platelet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610413669.2A CN107496982A (en) | 2016-06-14 | 2016-06-14 | Promote the derivative doctor's material and its preparation method of impaired bone repair and capillary proliferation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610413669.2A CN107496982A (en) | 2016-06-14 | 2016-06-14 | Promote the derivative doctor's material and its preparation method of impaired bone repair and capillary proliferation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107496982A true CN107496982A (en) | 2017-12-22 |
Family
ID=60678401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610413669.2A Pending CN107496982A (en) | 2016-06-14 | 2016-06-14 | Promote the derivative doctor's material and its preparation method of impaired bone repair and capillary proliferation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107496982A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112386345A (en) * | 2020-11-13 | 2021-02-23 | 苏州诺普再生医学有限公司 | Alveolar bone increment support system |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1403167A (en) * | 2002-09-26 | 2003-03-19 | 东南大学 | Hard tissue repairing material and its prepn |
| CN1403165A (en) * | 2002-09-26 | 2003-03-19 | 东南大学 | Active composition for repairing hard tissue and its prepn |
| CN1403166A (en) * | 2002-09-26 | 2003-03-19 | 东南大学 | Absorbable active tissue matter for repairing hard tissue and its prepn |
-
2016
- 2016-06-14 CN CN201610413669.2A patent/CN107496982A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1403167A (en) * | 2002-09-26 | 2003-03-19 | 东南大学 | Hard tissue repairing material and its prepn |
| CN1403165A (en) * | 2002-09-26 | 2003-03-19 | 东南大学 | Active composition for repairing hard tissue and its prepn |
| CN1403166A (en) * | 2002-09-26 | 2003-03-19 | 东南大学 | Absorbable active tissue matter for repairing hard tissue and its prepn |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112386345A (en) * | 2020-11-13 | 2021-02-23 | 苏州诺普再生医学有限公司 | Alveolar bone increment support system |
| CN112386345B (en) * | 2020-11-13 | 2021-07-13 | 苏州诺普再生医学有限公司 | Alveolar bone increment support system |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5368102B2 (en) | Maxillofacial bone enhancement using rhPDGF-BB and biocompatible matrix | |
| US10751185B2 (en) | Treatment of skeletal voids with implantable substrate hydrated with bone marrow concentrate | |
| US8546529B2 (en) | Injectable bone regeneration gel containing bone formation enhancing peptide | |
| US8563040B2 (en) | Compositions and methods for forming and strengthening bone | |
| AU782394B2 (en) | Compositions and methods for forming and strengthening bone | |
| Costantino et al. | Bone healing and bone substitutes | |
| KR101121146B1 (en) | Method for fixing an implant, fixing member for the implant and implant composite | |
| US20100172863A1 (en) | Enhanced medical implant | |
| MX2007004459A (en) | Platelet-derived growth factor compositions and methods of use thereof. | |
| US20080063681A1 (en) | Therapeutic bone replacement material | |
| KR20140038348A (en) | Compositions and methods for spine fusion procedures | |
| CN107771087A (en) | The semi-synthetic dusty material obtained by modified natural marine organism material composition, its preparation method and its application | |
| JP2001509419A (en) | Moldable bioactive composition | |
| Zhou et al. | Effect of Choukroun platelet-rich fibrin combined with autologous Micro-Morselized bone on the repair of mandibular defects in rabbits | |
| van Oirschot et al. | Fast degradable calcium phosphate cement for maxillofacial bone regeneration | |
| Bayat et al. | A comparison of bone reconstruction following application of bone matrix gelatin and autogenous bone grafts to alveolar defects: an animal study | |
| CN107496982A (en) | Promote the derivative doctor's material and its preparation method of impaired bone repair and capillary proliferation | |
| Zeng et al. | The progress of decellularized scaffold in stomatology | |
| RU2367475C1 (en) | Membrane to be used in targeted angiogenesis | |
| Vieira et al. | Effect of ozone therapy on the modulation of inflammation and on new bone formation in critical defects of rat calvaria filled with autogenous graft | |
| Sheikh et al. | Bone grafting | |
| Fuentes et al. | Mandibular dental implant placement using demineralized bone matrix (DBM) | |
| Grassi et al. | A new surgical protocol for horizontal ridge augmentation: simplified apposition technique. human histologic and radiographic analysis after 2.5 years of follow-up, a case report | |
| CN1158109C (en) | Biologically cmposite artificial bone and its preparing process | |
| JP2006122518A (en) | Composition for forming bone or periodontium |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171222 |