CN107485604A - A kind of safe ten thousand rhzomorph soluble powders of improved tartaric acid and preparation method thereof - Google Patents
A kind of safe ten thousand rhzomorph soluble powders of improved tartaric acid and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A—HUMAN NECESSITIES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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Abstract
The invention provides a kind of safe ten thousand rhzomorph soluble powders of improved tartaric acid, it is related to technical field of veterinary.The safe ten thousand rhzomorph soluble powders of the tartaric acid of the present invention include the component of following mass fraction：5~25 parts of ten thousand rhzomorph of tartaric acid Thailand；5~40 parts of cyclodextrin；45~85 parts of water-solubility carrier；0.1~1 part of acidity regulator；0.1~1 part of flavouring；0.05~0.5 part of phagostimulant.Said components sieving is mixed to get the safe ten thousand rhzomorph soluble powders of tartaric acid.The solubility of the safe ten thousand rhzomorph soluble powders of the tartaric acid of the present invention at room temperature can be with more than 20000ppm (in terms of safe ten thousand rhzomorphs of effective ingredient tartaric acid), and the common safe ten thousand rhzomorph soluble powder normal solubilities of tartaric acid are about 10000ppm, significantly improve the solubility of safe ten thousand rhzomorphs of tartaric acid, and stability is good, palatability is good, and drug bioavailability is high.
Description
Technical field
The present invention relates to technical field of veterinary, the safe ten thousand rhzomorph soluble powders of more particularly to a kind of improved tartaric acid and
Its preparation method.
Background technology
Ten thousand rhzomorphs (abbreviation AIV) of tartaric acid Thailand be it is semi-synthetic through biofermentation on the basis of tylosin obtained from it is a kind of
The special antibiotic of macrolides poultry.AIV is a kind of efficient macrolide antibiotics, passes through the 3-OH to tylosin
Acetylation and 4 〞-OH isoamyls are acylated and obtain.Research shows that AIV has strong affinity to 70S ribosomes, and cell membrane permeability is good,
Therefore antibacterial and mycoplasma vigor are above tylosin, and it has the branch of drug resistance to other antibiotic (including tylosin)
Substance is effective, there is very high application value.AIV has resistance activity to many gram-positive bacterias and some negative bacteriums, including
Mycoplasma, vibrios, spirillum and big virus, have the effect of uniqueness to chicken Deficiency Mycoplasma, pig popularity pneumonia, pig dysentery characterized by blood in the stool etc.,
And suitable for the prevention of the disease such as pneumonia caused by atrophic rhinitis, cholera fowl, chicken chronic respiratory disease, small Mycoplasma bovis
And treatment.Ten thousand rhzomorphs of tartaric acid Thailand have safety coefficient more broader than tylosin, are to have obvious curative effects to poultry mycoplasmosis
Ideal medicament.
Soluble auxiliary material used in the safe ten thousand rhzomorph soluble powders preparation of the tartaric acid of prior art is DEXTROSE ANHYDROUS or lactose
Deng substantially without solubilization-aid effect, under normal temperature, solubility is about 10000ppm (based on safe ten thousand rhzomorphs of effective ingredient vinic acid).In addition, because
Ten thousand rhzomorphs of tartaric acid Thailand have stronger bitter taste, and animal food refusal phenomenon occurs often for Clinical practice, do not reach expected prevention or control
Therapeutic effect.
The content of the invention
In view of this, the invention provides safe ten thousand rhzomorph soluble powders of a kind of improved tartaric acid and preparation method thereof, increase
Add the solubility range of the safe ten thousand rhzomorph soluble powders of tartaric acid, improve the bioavilability of medicine.
In order to solve the above-mentioned technical problem, technical scheme is as follows：
The invention provides a kind of safe ten thousand rhzomorph soluble powders of improved tartaric acid, include the component of following mass fraction：
Ten thousand rhzomorphs of tartaric acid Thailand：5~25 parts；
Cyclodextrin：5~40 parts；
Water-solubility carrier：45~85 parts；
Acidity regulator：0.1~1 part；
Flavouring：0.1~1 part；
Phagostimulant：0.05~0.5 part.
Preferably, the cyclodextrin is one or more of mixtures in water soluble Beta-cyclodextrin and its derivative.
Preferably, the water-solubility carrier is one kind in lactose, glucose, sucrose, maltodextrin and water soluble starch
Or several mixture.
Preferably, the acidity regulator is the one or more in maleic acid, citric acid, tartaric acid and fumaric acid.
Preferably, the flavouring is the one or more in Stevioside, saccharin sodium, aspartame and honey element.
Preferably, the phagostimulant is the one or more in fragrant sucking pig, ethylmaltol and food calling peptide.
Present invention also offers the preparation method of the safe ten thousand rhzomorph soluble powders of above-mentioned tartaric acid, comprise the following steps：By institute
State safe ten thousand rhzomorphs of acidity regulator, the flavouring, the phagostimulant, the water-solubility carrier, the tartaric acid, ring paste
Essence mixing, obtain the safe ten thousand rhzomorph soluble powders of tartaric acid.
Preferably, the preparation method of the safe ten thousand rhzomorph soluble powders of the tartaric acid, comprises the following steps：First by the tart flavour
Conditioning agent, the flavouring and the phagostimulant proportionally mix with the part water-solubility carrier；The mixing that will be obtained again
Thing ten thousand rhzomorphs safe with the tartaric acid, the remaining water-solubility carrier and the cyclodextrin mix, and obtain safe ten thousand rhzomorphs of tartaric acid
Soluble powder.
It is furthermore preferred that the water-solubility carrier mixed with the acidity regulator, the flavouring and the phagostimulant
Quality be the water-solubility carrier gross mass 20%~50%.
Preferably, the acidity regulator, the flavouring, the phagostimulant and the water-solubility carrier cross 60~80 mesh
Sieve.
Compared with prior art, the present invention has advantages below：
The safe ten thousand rhzomorph soluble powders of tartaric acid of the prior art are prepared using DEXTROSE ANHYDROUS, molten under its normal temperature
Xie Du is about 10000ppm (based on safe ten thousand rhzomorphs of effective ingredient vinic acid).The safe ten thousand rhzomorph soluble powders of tartaric acid of the present invention be by
Ten thousand rhzomorphs of tartaric acid Thailand, cyclodextrin, water-solubility carrier and appropriate acidity regulator, flavouring, phagostimulant are formulated.The present invention
The safe ten thousand rhzomorph soluble powder normal temperature of tartaric acid under solubility (based on safe ten thousand rhzomorphs of effective ingredient vinic acid) up to 20000ppm
More than, hence it is evident that improve the solubility range of safe ten thousand rhzomorphs of tartaric acid.Therefore, can facilitate plant using water fountain concentrated compounding to
Medicine, waterline will not be blocked, fully meet waterline administration requirements.
By adding suitable acidity regulator in the present invention, the biocompatibility of medicine is added, plays certain delay
Release effect and cover peculiar smell and foul smell, prevent oxidation of drug from decomposing, increase the stability of medicine；By adding flavouring and food calling
Agent, the bitter taste of medicine in itself is further effectively covered, improve the palatability of medicine, advantageously ensure that medicine intake, so as to
Improve the bioavilability of medicine.
The preparation method of the safe ten thousand rhzomorph soluble powders of the tartaric acid of the present invention, from finished product one-shot forming is dosed into, drug effect is not
By ectocine.
Embodiment
The invention provides a kind of safe ten thousand rhzomorph soluble powders of improved tartaric acid, include the component of following mass fraction：
Ten thousand rhzomorphs of tartaric acid Thailand：5~25 parts；
Cyclodextrin：5~40 parts；
Water-solubility carrier：45~85 parts；
Acidity regulator：0.1~1 part；
Flavouring：0.1~1 part；
Phagostimulant：0.05~0.5 part.
In the safe ten thousand rhzomorph soluble powders of the tartaric acid of the present invention, the mass fraction of safe ten thousand rhzomorphs of addition tartaric acid is 5~25
Part, preferably 8~19 parts, more preferably 13~16 parts.As the active ingredient of the safe ten thousand rhzomorph soluble powders of tartaric acid, tartaric acid
Safe ten thousand rhzomorphs mainly play sterilization functions by hindering the synthesis of bacterium protein, are easily absorbed in vivo, and excretion is rapid,
The noresidue in tissue, there is special efficacy to gram-positive bacteria, mycoplasma.Especially have to actinobacillus pleuropneumoniae very high
Activity, be treat mycoplasma caused by livestock and poultry chronic respiratory tract disease choice drug.Safe ten thousand rhzomorphs of paratartaric acid of the present invention
Source is not particularly limited, using safe ten thousand rhzomorphs of tartaric acid well-known to those skilled in the art.In the specific embodiment of the invention
It is middle to use safe ten thousand rhzomorphs of commercially available tartaric acid, purchased from Inner Mongol Zhong Mu Bioceuticals Inc..
In the safe ten thousand rhzomorph soluble powders of the tartaric acid of the present invention, cyclodextrin with the addition of.In the present invention, the matter of cyclodextrin addition
It is 5~40 parts to measure fraction, preferably 10~30 parts, more preferably 16~27 parts.In the present invention, cyclodextrin is added, is on the one hand had
Effect adds the solubility of the safe ten thousand rhzomorph soluble powders of tartaric acid, improves the bioavilability of medicine, is more convenient plant and uses
Water fountain concentrated compounding is administered；On the other hand also add the biocompatibility of medicine, play certain slow releasing function and cover peculiar smell and
Foul smell, prevent oxidation of drug from decomposing, increase the stability of medicine.The present invention is not particularly limited to the source of cyclodextrin, is used
Cyclodextrin well-known to those skilled in the art.Commercially available cyclodextrin is used in the specific embodiment of the invention, purchased from Liquan County
The limited industrial corporation of work.
In the present invention, cyclodextrin is one or more of mixtures in water soluble Beta-cyclodextrin and its derivative.Wherein, water
Soluble cyclodextrin is the one or more in alpha-cyclodextrin, beta-schardinger dextrin and gamma-cyclodextrin.Water soluble cyclodextrin derivant is hydroxyl
One or more in propyl-beta-cyclodextrin, methyl-B-cyclodextrin and carboxymethyl-beta-cyclodextrin.Water soluble Beta-cyclodextrin and its spread out
Biology there is stronger solubilising power, have extraordinary solubilizing effect for insoluble spices, lipophilic substance, wherein especially with
Beta-schardinger dextrin is optimal.Beta-schardinger dextrin can effectively safe ten thousand rhzomorphs of paratartaric acid included, drug molecule is entered β-ring paste
In the cavity of the hydrophobic lipophilic of essence, and hydrophilic radical increases its solubility in water away from cavity.
In the safe ten thousand rhzomorph soluble powders of the tartaric acid of the present invention, water-solubility carrier with the addition of.In the present invention, water-solubility carrier
The mass fraction of addition is 45~85 parts, preferably 52~76 parts, more preferably 59~64 parts.In the present invention, add water-soluble
Carrier, ensureing beyond product solubility property, mainly the stability and mobility for raising preparation, moreover it is possible to improve the suction of medicine
Yield and uptake.
In the present invention, water-solubility carrier is lactose, glucose, sucrose, maltodextrin, one kind in water soluble starch or several
The mixture of kind.The dissolubility of above-mentioned several water-solubility carriers is superior to safe ten thousand rhzomorphs of tartaric acid, is added thereto one or more,
The solubility of soluble powder is had no adverse effect.When the water-solubility carrier used is two or more mixture,
The present invention is not particularly limited to the mixed proportion of each water-solubility carrier, using the mixing of arbitrary proportion.Have in the present invention
In body embodiment, glucose is preferably DEXTROSE ANHYDROUS.
The present invention is not particularly limited to the source of water-solubility carrier, using water solubility well-known to those skilled in the art
Carrier.Commercially available water-solubility carrier is used in the specific embodiment of the invention.Wherein, DEXTROSE ANHYDROUS is purchased from the western king's medicine of Xi Wang groups
Industry company, maltodextrin are purchased from Shandong Xin great bio tech ltd.
In the safe ten thousand rhzomorph soluble powders of tartaric acid of the present invention, go back the acidity regulator of compatibility suitable proportion, flavouring and
Phagostimulant, effectively to cover the safe ten thousand rhzomorph medicines of tartaric acid stronger bitter taste in itself, improve the palatability of medicine, there is product
Animal palatability is obviously improved, advantageously ensures that medicine intake, so as to effectively improve the bioavilability of medicine.
In the safe ten thousand rhzomorph soluble powders of the tartaric acid of the present invention, the mass fraction for adding acidity regulator is 0.1~1 part,
Preferably 0.2~0.8 part, more preferably 0.4~0.6 part.Acidity regulator is added, in addition to flavor adjustment, moreover it is possible to effectively increase
Add the solubility of safe ten thousand rhzomorphs of tartaric acid, play the effect of good hydrotropy.
In the present invention, acidity regulator is the one or more in maleic acid, citric acid, tartaric acid and fumaric acid.When adopting
When acidity regulator is two or more mixture, the present invention is to the mixed proportion of each acidity regulator without spy
It is different to limit, using the mixing of arbitrary proportion.It is preferably L+ tartaric acid that the present invention, which uses acidity regulator,.On the one hand be because
Exist for safe ten thousand rhzomorphs in the form of tartrate, on the other hand, solubility property of the L+ tartaric acid in water is better than other several
Kind.
The present invention is not particularly limited to the source of acidity regulator, is adjusted using tart flavour well-known to those skilled in the art
Save agent.Commercially available acidity regulator is used in the specific embodiment of the invention.Wherein, L+ tartaric acid is purchased from the auspicious brilliant biotechnology in Hangzhou
Co., Ltd.
In the safe ten thousand rhzomorph soluble powders of the tartaric acid of the present invention, the mass fraction number for adding flavouring is 0.1~1 part, excellent
Elect 0.2~0.8 part, more preferably 0.4~0.6 part as.
In the present invention, flavouring is preferably sweet taste flavouring, is particularly preferred as Stevioside, saccharin sodium, aspartame, sweetness
One or more in element.When the flavouring used is two or more mixture, the present invention is to each flavouring
Mixed proportion is not particularly limited, using the mixing of arbitrary proportion.
The present invention is not particularly limited to the source of flavouring, using flavouring class well-known to those skilled in the art
Type.Commercially available flavouring is used in the specific embodiment of the invention.Wherein, honey element is purchased from Tianjin Beifang Food Co., Ltd..
In the safe ten thousand rhzomorph soluble powders of the tartaric acid of the present invention, the mass fraction for adding phagostimulant is 0.05~0.5 part, excellent
Elect 0.1~0.4 part, more preferably 0.2~0.3 part as.Phagostimulant plays attractant effect in the present invention, to the solubility of product without
Influence.
In the present invention, phagostimulant is preferably the one or more in fragrant sucking pig, ethylmaltol and food calling peptide.When use
When phagostimulant is two or more mixture, the present invention is not particularly limited to the mixed proportion of each phagostimulant, is used
The mixing of arbitrary proportion.
The present invention is not particularly limited to the source of phagostimulant, using phagostimulant class well-known to those skilled in the art
Type.Commercially available phagostimulant is used in the specific embodiment of the invention.Wherein, ethylmaltol is purchased from the extra large essence and flavoring agent of Xinglong County day profit
Co., Ltd.
Present invention also offers the preparation method of the safe ten thousand rhzomorph soluble powders of above-mentioned tartaric acid, comprise the following steps：By institute
State safe ten thousand rhzomorphs of acidity regulator, the flavouring, the phagostimulant, the water-solubility carrier, the tartaric acid, ring paste
Essence mixing, obtain the safe ten thousand rhzomorph soluble powders of tartaric acid.
The present invention is not particularly limited to the mode of mixing, is using hybrid mode well-known to those skilled in the art
Can.
As a preferred embodiment, in the present invention, first by the acidity regulator, the flavouring and described lure
Food agent proportionally mixes with the part water-solubility carrier；Again by safe ten thousand rhzomorphs of obtained mixture and the tartaric acid, surplus
The remaining water-solubility carrier and the cyclodextrin are proportionally well mixed, and obtain the safe ten thousand rhzomorph soluble powders of tartaric acid.
In the present invention, the water-solubility carrier that is mixed with the acidity regulator, the flavouring and the phagostimulant
Quality is the 20%~50% of the water-solubility carrier gross mass, preferably 25%~40%, more preferably 30%~35%.
In the present invention, acidity regulator, flavouring and phagostimulant and the part water-solubility carrier preferably first cross 60~80
Mesh sieve, after being more preferably 65~75 mesh sieves, then mixed.Or mixed using while sieving.
In the present invention, there is no special limit to the mode of acidity regulator, flavouring, phagostimulant and water-solubility carrier mixing
It is fixed.In order that mixing is more uniform, the present invention is mixed using the method diluted step by step.
Safe ten thousand bacterium of mixture and tartaric acid that acidity regulator, flavouring, phagostimulant and part aqueous carrier are obtained
Plain, remaining water-solubility carrier and cyclodextrin are proportionally well mixed.The present invention is not particularly limited to the mode of mixing, is used
Hybrid mode well-known to those skilled in the art.The safe ten thousand rhzomorph soluble powders of tartaric acid are obtained after mixing.
The solubility for the safe ten thousand rhzomorph soluble powders of tartaric acid that the present invention is prepared (in terms of safe ten thousand rhzomorphs of effective ingredient)
Normal temperature is issued to more than 20000ppm, and the safe ten thousand rhzomorph soluble powder normal solubilities of common tartaric acid are about 10000ppm, bright
The aobvious solubility range for improving safe ten thousand rhzomorphs of tartaric acid.Due to the increase of the safe ten thousand rhzomorph Drug levels of tartaric acid, in order to alleviate
The stronger bitter taste of medicine in itself, tartaric acid of the invention Thailand ten thousand rhzomorph soluble powders in also added appropriate acidity regulator,
Flavouring and phagostimulant, to improve the palatability of medicine, ensure medicine intake, so as to effectively improve the biological utilisation of medicine
Degree.
For the object, technical solutions and advantages of the present invention are more clearly understood, the present invention is entered with reference to embodiment
Row detailed description, but they can not be interpreted as limiting the scope of the present invention.
Embodiment 1
By safe ten thousand rhzomorphs of tartaric acid：Beta-schardinger dextrin：Lactose：DEXTROSE ANHYDROUS：Tartaric acid：Stevioside：Food calling peptide=16：6：
30：27：0.5：0.4：0.1 mass ratio prepares material, and its specific preparation process is：
(1) tartaric acid, Stevioside, food calling peptide, and a quarter of lactose and DEXTROSE ANHYDROUS gross mass are taken in proportion, one
Rise and pass through 60 mesh sieves, be added in mixer, be pre-mixed；
(2) take remaining material to be added in the mixed material of (1) step in proportion, start total mixed untill mixing；
(3) mixing terminates, and resulting material is carried out to pack to obtain finished product.
Ten thousand rhzomorph assays of tartaric acid Thailand：Reference《Veterinary drug national standard》(chemicals, middle powder stick) first product
Kind【Assay】Assay method under is carried out；【Dissolubility】Reference《Chinese veterinary pharmacopoeia》(2015 editions one) annex " preparation
In general rule " " soluble powder "【Dissolubility】Assay method under is carried out, and following examples are similarly.
After testing, the safe ten thousand rhzomorph soluble powders of tartaric acid being prepared, ten thousand rhzomorph contents of its tartaric acid Thailand are 20%, are surveyed
It is qualified in the case of 20000ppm to determine dissolubility.
When the safe ten thousand rhzomorph soluble powders of tartaric acid prepared by this method carry out live pig feeding, food refusal phenomenon does not occur.
Embodiment 2
By safe ten thousand rhzomorphs of tartaric acid：Hydroxypropyl-β-cyclodextrin：Maltodextrin：DEXTROSE ANHYDROUS：L+ tartaric acid：Honey element：
Ethylmaltol=25：25：23.7：25：0.8：0.16：0.34 mass ratio prepares material, and its specific preparation process is：
(1) maleic acid, honey element, ethylmaltol are taken in proportion, and the four of maltodextrin and DEXTROSE ANHYDROUS gross mass
/ mono-, together by 80 mesh sieves, sieve three times and be pre-mixed；
(2) remaining material and the mixed material of (1) step is taken to add the mixer sky hopper dried, cleaned together in proportion
In, start total mixed untill mixing；
(3) mixing terminates, and resulting material is carried out to pack to obtain finished product.
After testing, the safe ten thousand rhzomorph soluble powders of tartaric acid being prepared, ten thousand rhzomorph contents of its tartaric acid Thailand are 25%, molten
Solution property is qualified in the case of 20000ppm.
When the safe ten thousand rhzomorph soluble powders of tartaric acid prepared by this method carry out live pig feeding, food refusal phenomenon does not occur.
Embodiment 3
By safe ten thousand rhzomorphs of tartaric acid：Beta-schardinger dextrin：Water soluble starch：Sucrose：Citric acid：Saccharin sodium：Ethylmaltol=
6：35：17.5：40：0.2：0.8：0.5 mass ratio prepares material, and its specific preparation process is：
(1) recipe quantity is pressed, adds safe ten thousand rhzomorphs of tartaric acid, beta-schardinger dextrin, citric acid, saccharin sodium, ethylmaltol, and
Water soluble starch and sucrose, which add, to be dried, in the mixer sky hopper of cleaning, is started total mixed untill mixing；
(2) mixing terminates, and resulting material is carried out to pack to obtain finished product.
After testing, the safe ten thousand rhzomorph soluble powders of tartaric acid being prepared, ten thousand rhzomorph contents of its tartaric acid Thailand are 6%, molten
Solution property is qualified in the case of 20000ppm.
When the safe ten thousand rhzomorph soluble powders of tartaric acid prepared by this method carry out live pig feeding, food refusal phenomenon does not occur.
Embodiment 4
By safe ten thousand rhzomorphs of tartaric acid：Beta-schardinger dextrin：Lactose：Fumaric acid：Aspartame：Sucking pig perfume=20：7.8：70：1：1：
0.2 mass ratio prepares material, and its specific preparation process is：
(1) take fumaric acid, aspartame, sucking pig fragrant in proportion, and a quarter of lactose gross mass, pass through 80 mesh together
Sieve, is added in mixer and is pre-mixed；
(2) take remaining material to be added in the mixed material of (1) step in proportion, start total mixed untill mixing；
(3) mixing terminates, and resulting material is carried out to pack to obtain finished product.
After testing, the safe ten thousand rhzomorph soluble powders of tartaric acid being prepared, ten thousand rhzomorph contents of its tartaric acid Thailand are 20%, molten
Solution property is qualified in the case of 20000ppm.
When the safe ten thousand rhzomorph soluble powders of tartaric acid prepared by this method carry out live pig feeding, food refusal phenomenon does not occur.
Comparative example 1
By safe ten thousand rhzomorphs of tartaric acid：DEXTROSE ANHYDROUS=20：80 mass ratio prepares material, crosses 80 mesh sieves, adds to mixing
It is sufficiently mixed in machine, obtains the safe ten thousand rhzomorph soluble powders of tartaric acid.
After testing, the safe ten thousand rhzomorph soluble powders of tartaric acid being prepared, ten thousand rhzomorph contents of its tartaric acid Thailand are 20%, molten
Xie Du is qualified in the case of 10000ppm, and is unqualified in the case of 20000ppm.
When the safe ten thousand rhzomorph soluble powders of tartaric acid prepared by this method carry out live pig feeding, there is food refusal phenomenon.
Comparative example 2
By safe ten thousand rhzomorphs of tartaric acid：Lactose=20：80 mass ratio prepares material, crosses 80 mesh sieves, adds in mixer
Row is sufficiently mixed, and obtains the safe ten thousand rhzomorph soluble powders of tartaric acid.
After testing, the safe ten thousand rhzomorph soluble powders of tartaric acid being prepared, ten thousand rhzomorph contents of its tartaric acid Thailand are 20%, molten
Xie Du is qualified in the case of 10000ppm, and is unqualified in the case of 20000ppm.
When the safe ten thousand rhzomorph soluble powders of tartaric acid prepared by this method carry out live pig feeding, there is food refusal phenomenon.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
- A kind of 1. safe ten thousand rhzomorph soluble powders of improved tartaric acid, it is characterised in that：Include the component of following mass fraction：Ten thousand rhzomorphs of tartaric acid Thailand：5~25 parts；Cyclodextrin：5~40 parts；Water-solubility carrier：45~85 parts；Acidity regulator：0.1~1 part；Flavouring：0.1~1 part；Phagostimulant：0.05~0.5 part.
- 2. the safe ten thousand rhzomorph soluble powders of tartaric acid according to claim 1, it is characterised in that：The cyclodextrin is water solubility One or more of mixtures in cyclodextrin and its derivative.
- 3. the safe ten thousand rhzomorph soluble powders of tartaric acid according to claim 1, it is characterised in that：The water-solubility carrier is breast One or more of mixtures in sugar, glucose, sucrose, maltodextrin, water soluble starch.
- 4. the safe ten thousand rhzomorph soluble powders of tartaric acid according to claim 1, it is characterised in that：The acidity regulator is horse The one or more come in sour, citric acid, tartaric acid and fumaric acid.
- 5. the safe ten thousand rhzomorph soluble powders of tartaric acid according to claim 1, it is characterised in that：The flavouring is stevia rebaudianum One or more in glucoside, saccharin sodium, aspartame and honey element.
- 6. the safe ten thousand rhzomorph soluble powders of tartaric acid according to claim 1, it is characterised in that：The phagostimulant is sucking pig One or more in fragrant, ethylmaltol and food calling peptide.
- 7. the preparation method of ten thousand rhzomorph soluble powders of tartaric acid Thailand as described in claim 1~6, it is characterised in that including following Step：By the acidity regulator, the flavouring, the phagostimulant, the water-solubility carrier, safe ten thousand rhzomorphs of the tartaric acid, The cyclodextrin mixing, obtain the safe ten thousand rhzomorph soluble powders of tartaric acid.
- 8. preparation method according to claim 7, it is characterised in that first by the acidity regulator, the flavouring and The phagostimulant proportionally mixes with the part water-solubility carrier；Again by obtained mixture and safe ten thousand bacterium of the tartaric acid Element, the remaining water-solubility carrier and cyclodextrin mixing, obtain the safe ten thousand rhzomorph soluble powders of tartaric acid.
- 9. preparation method according to claim 8, it is characterised in that with the acidity regulator, the flavouring and institute The quality for stating the water-solubility carrier of phagostimulant mixing is the 20%~50% of the water-solubility carrier gross mass.
- 10. according to the preparation method described in claim 7~9 any one, it is characterised in that the acidity regulator, described Flavouring, the phagostimulant and the water-solubility carrier cross 60~80 mesh sieves.
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| CN114642641A (en) * | 2022-05-24 | 2022-06-21 | 山东国邦药业有限公司 | Tylosin tartrate water-soluble granules and preparation method thereof |
| CN114652733A (en) * | 2022-05-25 | 2022-06-24 | 山东国邦药业有限公司 | Tylosin tartrate premix and preparation method thereof |
| CN114699376A (en) * | 2022-03-24 | 2022-07-05 | 浙江大飞龙动物保健品股份有限公司 | Tylosin tartrate effervescent granules for livestock and preparation method thereof |
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| CN109381443A (en) * | 2018-09-27 | 2019-02-26 | 佛山市正典生物技术有限公司 | Ten thousand rhzomorph microcapsules of a kind of tartaric acid Thailand and preparation method thereof |
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| CN114028338A (en) * | 2021-12-28 | 2022-02-11 | 江西英特科胜动保科技有限公司 | Preparation method and application of water-soluble tylosin tartrate premix |
| CN114028338B (en) * | 2021-12-28 | 2023-11-03 | 江西英特科胜动保科技有限公司 | Preparation method and application of water-soluble telavancin tartrate premix |
| CN114469869A (en) * | 2022-01-14 | 2022-05-13 | 广州市和生堂动物药业有限公司 | Tylosin tartrate premix and preparation method thereof |
| CN114469869B (en) * | 2022-01-14 | 2022-10-25 | 广州市和生堂动物药业有限公司 | Tylosin tartrate premix and preparation method thereof |
| CN114699376A (en) * | 2022-03-24 | 2022-07-05 | 浙江大飞龙动物保健品股份有限公司 | Tylosin tartrate effervescent granules for livestock and preparation method thereof |
| CN114642641A (en) * | 2022-05-24 | 2022-06-21 | 山东国邦药业有限公司 | Tylosin tartrate water-soluble granules and preparation method thereof |
| CN114642641B (en) * | 2022-05-24 | 2022-07-26 | 山东国邦药业有限公司 | Tylosin tartrate water-soluble granules and preparation method thereof |
| CN114652733A (en) * | 2022-05-25 | 2022-06-24 | 山东国邦药业有限公司 | Tylosin tartrate premix and preparation method thereof |
| CN115896217A (en) * | 2022-12-16 | 2023-04-04 | 内蒙古中牧生物药业有限公司 | Feed supplementing process for improving fermentation level of tulathromycin |
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Application publication date: 20171219 |