CN107485366A - A kind of optics Micro flow contrast imaging method based on microvesicle enhancing - Google Patents

A kind of optics Micro flow contrast imaging method based on microvesicle enhancing Download PDF

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CN107485366A
CN107485366A CN201710800259.8A CN201710800259A CN107485366A CN 107485366 A CN107485366 A CN 107485366A CN 201710800259 A CN201710800259 A CN 201710800259A CN 107485366 A CN107485366 A CN 107485366A
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microvesicle
enhancing
optics
micro flow
high speed
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CN107485366B (en
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田洁
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Tianjin Hengyu Medical Technology Co ltd
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Tianjin Hengyu Medical Technology Co Ltd
Tianjin Hairen Medical Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0066—Optical coherence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00—Evaluating a particular growth phase or type of persons or animals
    • A61B2503/40—Animals

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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

The present invention proposes a kind of optics Micro flow contrast imaging method based on microvesicle enhancing.High speed interference of light computed tomography (SPECT) system platform has been built in present invention design, and design verification carries out the experimental program of Micro flow contrast imaging enhancing using microvesicle, then by the way that the experimental data of collection is analyzed, it was demonstrated that microvesicle has more significant effect in Imaging enhanced.Thus it is a kind of very effective Enhancement Method that the optics microangiography method proposed by the present invention based on microvesicle enhancing, which can be explained,.

Description

A kind of optics Micro flow contrast imaging method based on microvesicle enhancing
Technical field
The present invention relates to optics Micro flow contrast imaging technical field, specially a kind of micro- blood of optics based on microvesicle enhancing Pipe contrast imaging method.
Background technology
OCT（Optical coherence tomography）, it is a new imaging technique caused by 90 years 20th century.The technology is in medical science There are high-resolution, non-intrusion type imaging features using upper.OCT can be divided into time domain OCT and frequency domain OCT, its frequency domain OCT scan Speed is far longer than time domain OCT, has been substituted time domain OCT.Using OCT carry out optics microangiography be proposed in recent years one Individual new technology, the technology combination oct tomoscans, the capilary under tissue can be imaged without injecting contrast agent, and With high resolution ratio.Micro flow contrast imaging technology, it is broadly divided into based on strength information blood vessel imaging and based on intensity phase The blood vessel imaging method that position information combines.It is simple to data acquisition request based on strength information method, but for details imaging and The relative imaging method combined based on intensity and phase information of overall imaging effect has certain gap.The present invention utilizes and is based on phase The algorithm combination microbubble contrast agent combined with strength information strengthens optics microangiography image.
Microvesicle is as a kind of enhancing contrast agent in the medical imaging field extensive use such as ultrasonic imaging and CT imagings.And And universal approval is also obtained to the effect that ultrasonoscopy strengthens using microvesicle.Microvesicle is by injecting intravasation, then The histoorgan for needing to detect is reached by blood circulation, the excitation by ultrasound to microvesicle, ultrasonic imaging can be strengthened Effect of visualization.
The method for carrying out microangiography lifting image enhaucament based on OCT combinations microvesicle, there is scholar to propose to utilize intensity side Difference method combination microvesicle, which carries out angiogram, can improve imaging effect, but based on simple hot spot intensity variance for details and Noise-sensitive sex expression is poor, and the method combination microvesicle that the present invention proposes to combine using phase and amplitude carries out contrast imaging, this Method is preferable to axis information and noise-sensitive sex expression, but requires higher to imaging system and algorithm, and the present invention enters to system Row design is simultaneously effectively combined to system and algorithm and experiment.
Using high speed frequency sweep or spectral domain optics Micro flow contrast imaging, from based on amplitude and phase information and utilizing Microvesicle carries out image enhaucament, can reach more obvious effect, and the present invention proposes simultaneously design verification the method.
The content of the invention
The present invention relates to it is a kind of based on microvesicle enhancing optics Micro flow contrast imaging method, including：The micro- blood of high speed Pipe angiography system is built, experimental method design, microvesicle enhancing capilary imaging, data analysis.
A kind of optics Micro flow contrast imaging method based on microvesicle enhancing, including：
（1）High speed frequency sweep interference of light computed tomography (SPECT) system platform or high speed spectrum interference of light computed tomography (SPECT) system are built；
（2）Optics capilary enhanced scheme experimental design based on microvesicle；
（3）Optics capilary Enhanced Imaging algorithm based on microvesicle；
（4）Data analysis and contrast.
Further, high speed frequency sweep interference of light computed tomography (SPECT) system platform includes：
（1）High speed swept light source：Quick scan characteristic meets imaging acquisition speed, and long coherence characteristic meets scanning depth scope.
（2）Large area scanning is popped one's head in：The adaptable probe with high speed swept light source and resolution requirement.
（3）Balanced detector
（4）Motion-control module
（5）PC and image control system：Galvanometer, light source and collection cooperate.
Further, high speed spectral domain interference of light computed tomography (SPECT) system platform includes：
（1）Wideband light source：Interference centre wavelength and bandwidth meet the interference light source of device requirement.
（2）Spectrometer：For interference light spectrum analysis
（3）High-speed CCD
（4）Motion-control module
（5）PC and image control system：Galvanometer, light source and collection cooperate
Further, the optics capilary Enhanced Imaging algorithm based on microvesicle is：Utilize signal strength information and phase information phase With reference to microangiography algorithm, to without microvesicle scanning group data and thering is microvesicle scanning group data to be imaged respectively.
Further, contrasted for different groups of imaging results, image difference before and after analysis microvesicle enhancing, draw enhancing Conclusion.
The invention provides a kind of optics Micro flow contrast imaging method based on microvesicle enhancing.Possess following beneficial to effect Fruit：
The present invention propose using phase and amplitude combine method combination microvesicle progress contrast imaging, the method to axis information with Noise-sensitive sex expression is preferable, but requires higher to imaging system and algorithm, the present invention system is designed and to system and Algorithm and experiment are effectively combined.
Using high speed frequency sweep or spectral domain optics Micro flow contrast imaging, from based on amplitude and phase information and utilizing Microvesicle carries out image enhaucament, can reach more obvious effect, and the present invention proposes simultaneously design verification the method.
Brief description of the drawings
Fig. 1 is high speed microangiography system building structural representation of the present invention.
Fig. 2 is high speed microangiography system building structural representation of the present invention.
Fig. 3 is that the data of scanning collection of the present invention make imaging schematic diagram.
Fig. 4 obtains blood flow information schematic diagram for present invention projection.
The microangiography datagram that Fig. 5 is gathered when being present invention injection microvesicle.
Fig. 6 is the data that the present invention injects that scanning collection obtains after 2 minutes after microvesicle.
Fig. 7 is the Data Data of present invention acquisition scans after 8 minutes.
Fig. 8 is the data of 15 minutes acquisition scans of the invention.
Fig. 9 is that small white mouse ear of the present invention does not carry out microvesicle injection contrast imaging.
Figure 10 is the data of scanning in 2 minutes after present invention injection microbubble solution.
Figure 11 is the image data of present invention injection scanning in 8 minutes.
Embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete Site preparation describes, it is clear that described embodiment is only part of the embodiment of the present invention, rather than whole embodiments.It is based on Embodiment in the present invention, those of ordinary skill in the art are obtained every other under the premise of creative work is not made Embodiment, belong to the scope of protection of the invention.
As shown in figure 1, embodiment of the present invention includes three parts, high speed optical microangiography system building, experiment
The high speed microangiography system building of embodiment one
Referring to Fig. 1, the present embodiment includes：Feux rouges 1, high speed swept light source or wideband light source 2, fiber coupler 3, reference arm, XY scanning galvanometers 5, probe 6, interferometer 7, data acquisition module 8, oct angiograms algorithm 9, image system 10, data transfer 11, sample arm 12, control card 13.
High speed swept light source or wideband light source 2：High speed microangiography system design is large scale and high accuracy scanning system：Institute Light source is sweep velocity 200KHZ, long coherence light source.It can ensure in the case of certain depth, can still realize The imaging penetration depth of effect, tissue penetration depths are up to nearly 2mm.Small range scanning is designed as, is built with wideband light source based on light The high-velocity scanning system of spectral domain, sweep speed are determined by CCD speed, use CCD speed as 145KHZ.
XY scanning galvanometers：Galvanometer control is controlled using output control card mode, and vibration mirror scanning scope is reachable 10mmx10mm is imaged on a large scale.Galvanometer vibration mode and light source output signal and inter-frame synchronization signal keep synchronous.
Probe：The a wide range of imaging of design, preceding summary ensure that lateral resolution can not reduce, and distortion can not increase.Therefore exist During objective lens design of popping one's head in, increase anti-distortion piece, and ensure that numerical aperture will not reduce lateral resolution.
Data acquisition module：Data acquisition uses Alazartech9373 high-speed data acquisition cards, and acquisition control is by PC master Machine is sent.Data transfer is transferred to internal memory by PCI-E and carries out data prediction and conversion.
Image system：The tomographic data gathered in real time is shown, and image interactive adjustment is provided.By in image system The control of galvanometer galvanometer is added, also needs to add CCD controls for spectral domain interference of light system, areas imaging can be adjusted in real time and adopted Collect speed.By adding piezoelectric ceramics control module in image system, beam path alignment piezoelectric ceramics adjuster can be adjusted, Piezoelectric ceramics regulation can be calibrated directly by software to beam path alignment, user-friendly.
Embodiment controls：High speed swept light source or wideband light source 2, reference arm 4, sample arm 12, optical fiber coupling Clutch 3 forms an optical interferometer, feux rouges 1, collimation positioning action is played as collimation laser.Control card is controlled XY galvanometers, and And vibration mirror scanning speed and frame rate are set, light source scanning sets synchronous.The signal that data acquisition card module exports to interferometer Collection discrepancy internal memory, and storage dish is write by internal memory.By calling optics microangiography algorithm to be carried out to storage dish data Imaging operation, man-machine interaction is carried out with reference to image system.
The experimental method of embodiment two designs
Referring to Fig. 3, the present embodiment includes：Experimental design 14, test acceptor selection 16, new zealand rabbit 15, small white mouse 17, ear 18, control group 19, microvesicle injection 20, data processing 21, sweep time sets 22,23 is scanned after injection immediately, when being separated by different Between 24, data processing 21.
Sweep time is set：Refer to when selecting the acceptor of animal to test, dividing different time to dynamic after injection microvesicle Thing tissue site carries out experimental data scanning collection.
Microvesicle is injected：The animal recipient of selection is injected using the microbubble reagent of preparation.The present embodiment, using lipid Microvesicle prepares solution as injection reagent.Scanning collection data are disturbed to avoid injecting wound, for acceptor new zealand rabbit to a left side Ear is injected, and scanning auris dextra carries out data acquisition.Equally, for small white mouse, injected using leg, scan auris dextra gathered data.
Data processing：It is micro- using adding amplitude information algorithm to carry out based on phase for the data gathered according to testing program Angiographic imaging.
Embodiment controls：Design the microangiography experimental program based on microvesicle enhancing, choice experiment animal Individual, two animals of this experimental selection new zealand rabbit and small white mouse select ear to be done de- as scanned position as experimental subjects Hair processing.Control group, control group are set：Processing acquisition is carried out for not doing the data of microvesicle injection experimental subjects scanning Microangiography image.For injecting animal individual, data acquisition is carried out respectively according to the period after injection, is divided into scanning Gather immediately afterwards, several period scannings after scanning.Finally, imaging is done for the data of scanning collection.
The microvesicle of embodiment three strengthens Micro flow contrast imaging.
Based on oct tomoscans carry out Micro flow contrast imaging method, be generally basede on signal amplitude information carry out radiography into As calculating.Also, image data used in calculating is all based on carrying out in the case of no microvesicle radiography.The present embodiment displaying is a kind of Method based on phase plus amplitude information carries out contrast imaging to the data scanned after injection microvesicle.
Referring to Fig. 4, the present embodiment includes following components：Interference signal 22, frame arrangement 23, motion compensation 24, phase Position and amplitude information analysis 25, blood flow information extraction 26.
Interference signal 22：The signal acquisition that is exported by acquisition module to detector is simultaneously saved in the original letter of storage dish Number.
Frame arranges 23：Configured for hardware surface sweeping speed and contrast imaging algorithm parameter, be arranged on same position scanning The frequency n of frame, and using the n frame pictures as the reference images data for calculating current location tomography blood flow data.
Motion compensation 24：In surface sweeping gathered data, probe and tissue can produce relative motion, and this relative motion can give Calculate Micro flow contrast imaging and bring influence of noise, and have a strong impact on effect of visualization.Thus motion compensation process is introduced, is transported By estimating frame matching kinematic error to carrying out images match in continuous interframe baseline or field window, then dynamic compensation is Error is eliminated by inverse transformation.
Phase and amplitude analysis 25：The initial data of collection is parsed into amplitude and phase letter by Fourier transformation The complex signal of breath.The frame number continuously scanned using same position, build complex matrix.It can be obtained with phase and amplitude by solving The characteristic value and characteristic vector of the matrix of information.
Blood flow information extraction 26：According to the characteristic vector and characteristic value information of solution, with reference to PCA, to blood flow Information is extracted.Then intensity projection is carried out to all tomography cross section informations using enface algorithms and obtains blood flow information.
Example IV data analysis
The present embodiment contrasts to the data obtained after experiment.By data comparison, it can be found that injection microvesicle traversing of probe The data of collection have more obvious difference.It refer to Fig. 5, Fig. 6, Fig. 7, Fig. 8：Fig. 5 is when not carrying out injection microvesicle, to adopt New Zealand's auris dextra microangiography data of collection.Fig. 6 is to inject the data that scanning collection obtains after 2 minutes after microvesicle, Fig. 78 The data of acquisition scans after minute, Fig. 8 are the data of 15 minutes acquisition scans.As can be seen here, micro- blood after microvesicle injection is carried out Pipe radiography image shows more horn of plenty in terms of capilary details, increases with the time, and microbubble concentration reduces in blood, fine vascular Quantity display is reduced.Fig. 9 is that small white mouse ear does not carry out microvesicle injection contrast imaging, and Figure 10 is to be swept within 2 minutes after injecting microbubble solution The data retouched, Figure 11 are the image data of injection scanning in 8 minutes.Small white mouse ear vascular detail after microvesicle is injected also has increase, Increasing microbubble concentration in blood over time is reduced, and vascular detail quantity is accordingly reduced.As can be seen here, microvesicle is injected for optics Micro flow contrast imaging enhancing has significant effect.
It should be noted that herein, such as first and second or the like relational terms are used merely to a reality Body or operation make a distinction with another entity or operation, and not necessarily require or imply and deposited between these entities or operation In any this actual relation or order.Moreover, term " comprising ", "comprising" or its any other variant are intended to Nonexcludability includes, so that process, method, article or equipment including a series of elements not only will including those Element, but also the other element including being not expressly set out, or it is this process, method, article or equipment also to include Intrinsic key element.In the absence of more restrictions.By sentence " including one ... the key element limited, it is not excluded that Other identical element in the process including the key element, method, article or equipment also be present ".
Although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with A variety of changes, modification can be carried out to these embodiments, replace without departing from the principles and spirit of the present invention by understanding And modification, the scope of the present invention is defined by the appended.

Claims (5)

  1. A kind of 1. optics Micro flow contrast imaging method based on microvesicle enhancing, it is characterised in that：Including：
    （1）High speed frequency sweep interference of light computed tomography (SPECT) system platform or high speed spectrum interference of light computed tomography (SPECT) system are built；
    （2）Optics capilary enhanced scheme experimental design based on microvesicle；
    （3）Optics capilary Enhanced Imaging algorithm based on microvesicle；
    （4）Data analysis and contrast.
  2. 2. according to a kind of optics Micro flow contrast imaging method based on microvesicle enhancing described in claim 1, it is characterised in that： High speed frequency sweep interference of light computed tomography (SPECT) system platform includes：
    （1）High speed swept light source：Quick scan characteristic meets imaging acquisition speed, and long coherence characteristic meets scanning depth scope；
    （2）Large area scanning is popped one's head in：The adaptable probe with high speed swept light source and resolution requirement；
    （3）Balanced detector
    （4）Motion-control module
    （5）PC and image control system：Galvanometer, light source and collection cooperate.
  3. 3. according to a kind of optics Micro flow contrast imaging method based on microvesicle enhancing described in claim 1, it is characterised in that： High speed spectral domain interference of light computed tomography (SPECT) system platform includes：
    （1）Wideband light source：Interference centre wavelength and bandwidth meet the interference light source of device requirement；
    （2）Spectrometer：For interference light spectrum analysis
    （3）High-speed CCD
    （4）Motion-control module
    （5）PC and image control system：Galvanometer, light source and collection cooperate.
  4. 4. according to a kind of optics Micro flow contrast imaging method based on microvesicle enhancing described in claim 1, it is characterised in that： Optics capilary Enhanced Imaging algorithm based on microvesicle is：The capilary being combined using signal strength information and phase information is made Shadow algorithm, to without microvesicle scanning group data and thering is microvesicle scanning group data to be imaged respectively.
  5. 5. according to a kind of optics Micro flow contrast imaging method based on microvesicle enhancing described in claim 1, it is characterised in that： Contrasted for different groups of imaging results, image difference before and after analysis microvesicle enhancing, draw enhancing conclusion.
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109171670A (en) * 2018-06-25 2019-01-11 天津海仁医疗技术有限公司 A kind of 3D blood vessel imaging algorithm based on reverse Principal Component Analysis
CN111493832A (en) * 2020-04-24 2020-08-07 天津恒宇医疗科技有限公司 Enface-OCT-based endoscopic imaging method

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US20050171433A1 (en) * 2004-01-08 2005-08-04 Boppart Stephen A. Multi-functional plasmon-resonant contrast agents for optical coherence tomography
CN105342568A (en) * 2015-11-26 2016-02-24 上海交通大学 Optical coherence tomography method and system combining phase and amplitude
CN106028921A (en) * 2014-03-04 2016-10-12 南加利福尼亚大学 Optical coherence tomography system for health characterization of an eye
CN106166058A (en) * 2016-08-04 2016-11-30 温州医科大学 One is applied to optical coherence tomography blood vessel imaging method and OCT system

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Publication number Priority date Publication date Assignee Title
US20050171433A1 (en) * 2004-01-08 2005-08-04 Boppart Stephen A. Multi-functional plasmon-resonant contrast agents for optical coherence tomography
CN106028921A (en) * 2014-03-04 2016-10-12 南加利福尼亚大学 Optical coherence tomography system for health characterization of an eye
CN105342568A (en) * 2015-11-26 2016-02-24 上海交通大学 Optical coherence tomography method and system combining phase and amplitude
CN106166058A (en) * 2016-08-04 2016-11-30 温州医科大学 One is applied to optical coherence tomography blood vessel imaging method and OCT system

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109171670A (en) * 2018-06-25 2019-01-11 天津海仁医疗技术有限公司 A kind of 3D blood vessel imaging algorithm based on reverse Principal Component Analysis
CN109171670B (en) * 2018-06-25 2021-02-05 天津海仁医疗技术有限公司 3D blood vessel imaging algorithm based on reverse principal component analysis method
CN111493832A (en) * 2020-04-24 2020-08-07 天津恒宇医疗科技有限公司 Enface-OCT-based endoscopic imaging method

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