CN107468976B

CN107468976B - Zuanshanfeng mixture

Info

Publication number: CN107468976B
Application number: CN201710768546.5A
Authority: CN
Inventors: 杨剑佩; 罗俊伟; 龚小军
Original assignee: Jiangxi Jinding Pharmaceutical Co ltd
Current assignee: Jiangxi Jinding Pharmaceutical Co ltd
Priority date: 2017-08-31
Filing date: 2017-08-31
Publication date: 2021-01-29
Anticipated expiration: 2037-08-31
Also published as: CN107468976A

Abstract

The invention relates to a traditional Chinese medicine mixture, in particular to a Zuanshanfeng mixture, which comprises the following raw materials in parts by weight: 800-2000g of Zuanshanfeng, 20-50g of four-piece tile, 50-110g of radix clematidis, 60-230g of philippine flemingia root, 80-200g of Fengcheng caulis spatholobi, 20-60g of alpinia japonica, 10-60g of rhizoma gastrodiae, 10-50g of codonopsis pilosula, 12-55g of astragalus mongholicus, 15-100g of jujube kernel and 5-40g of wolfberry fruit. The invention has the effects of dispelling wind and eliminating dampness, eliminating stasis and relieving pain, relaxing tendons and activating collaterals and the like, and is used for treating symptoms such as cold pain of waist and knees, numbness of limbs, difficult flexion and the like caused by wind-cold-dampness arthralgia.

Description

Zuanshanfeng mixture

Technical Field

The invention relates to a traditional Chinese medicine mixture, in particular to a Zuanshanfeng mixture.

Background

Rheumatoid Arthritis (RA) is called Rheumatoid disease for short, and is a multi-system inflammatory autoimmune disease mainly involving peripheral joints, and Chinese medicine considers that diseases are caused by qi and blood obstruction of meridians and collaterals, and joint and muscle obstruction are caused by wind, cold and dampness, so that the basic principles of treating arthralgia syndrome are adopted, such as dispelling wind, dispelling cold, removing dampness, dredging meridians and collaterals, and the like. China has a large population, and particularly, diseases such as rheumatoid and rheumatoid arthritis are quite common clinically with the gradual arrival of the aging society.

Fissistigma Oldhamii (Fissistigma Oldhamii) belonging to genus Fissistigma of family Annonaceae, has effects of dispelling pathogenic wind, removing dampness, relieving pain, relieving swelling, promoting blood circulation, removing blood stasis, and treating traumatic injury, arthritis and ischialgia. The traditional Zuanshanfeng syrup is a traditional Chinese medicine compound preparation consisting of 7 medicines of Zuanshanfeng, gambir, Sichuan, clematis root, philippine flemingia root, Fengcheng spatholobus stem and alpinia japonica, and has certain effects on expelling wind and removing dampness, eliminating stasis and relieving pain, relaxing tendons and activating collaterals and the like. However, the preparation mainly has the effects of relieving pain, eliminating dampness and repairing joints, and has little effect on improving the autoimmunity of human bodies, so the medicine effect is not good, and patients often need to take a large amount of the preparation for a long time to play a certain role. Therefore, there is a need to develop a formulation of Zuanshanfeng with better therapeutic effect.

Disclosure of Invention

In order to overcome the defects of the prior art, the invention provides a Zuanshanfeng mixture, which greatly improves the curative effect of the Zuanshanfeng preparation in the aspect of treating rheumatoid arthritis.

In order to achieve the purpose, the invention adopts the technical scheme that:

the Zuanshanfeng mixture comprises the following raw materials in parts by weight:

800-2000g of Zuanshanfeng, 20-50g of four-piece tile, 50-110g of radix clematidis, 60-230g of philippine flemingia root, 80-200g of Fengcheng caulis spatholobi, 20-60g of alpinia japonica, 10-60g of rhizoma gastrodiae, 10-50g of codonopsis pilosula, 12-55g of astragalus mongholicus, 15-100g of jujube kernel and 5-40g of wolfberry fruit.

Preferably, the Zuanshanfeng mixture also comprises the following two raw materials in parts by weight: 800g of cane sugar and 1-5g of benzoic acid;

more preferably, the amount of sucrose is 500g and the amount of benzoic acid is 3 g.

Preferably, the Zuanshanfeng mixture comprises the following raw materials in parts by weight:

1400g of Zuanshanfeng, 35g of four tiles, 80g of radix clematidis, 160g of philippine flemingia root, 150g of Fengcheng caulis spatholobi, 45g of alpinia japonica, 30g of rhizoma gastrodiae, 20g of codonopsis pilosula, 24g of astragalus mongholicus, 20g of jujube kernel and 10g of wolfberry fruit.

Preferably, the Zuanshanfeng mixture also comprises the following raw materials in parts by weight:

23-43g of ricefield eel vine and 20-40g of orientvine vine.

The preparation method of the Zuanshanfeng mixture comprises the following steps:

(1) chopping the selected tile and the alpinia japonica into coarse powder, percolating the coarse powder by using 50-80% of ethanol solution in percentage by mass until the coarse powder is colorless, and collecting percolate for later use;

(2) cleaning raw materials including radix Fissistigmatis Oldhamii, radix Clematidis, radix Flemingiae Philippinensis, caulis Spatholobi, caulis Monopteri albi and caulis Sinomenii, decocting respectively for 2-4 times (each for 2-5 hr), filtering each raw material to obtain filtrate, mixing, concentrating until the relative density at 70 deg.C is less than 1.14, and cooling;

(3) cleaning rhizoma Gastrodiae, radix Codonopsis, radix astragali, semen Ziziphi Spinosae and fructus Lycii, decocting respectively for 2-4 times (each for 1.5-3 hr), filtering to obtain filtrate, mixing, concentrating until the relative density at 70 deg.C is less than 1.14, and cooling;

(4) and (3) mixing the liquids obtained in the steps (1) to (3), uniformly stirring, standing for 48 hours, filtering and filling to obtain the product.

Preferably, the mass fraction of the ethanol solution in the step (1) is 75%.

Preferably, the relative density of the concentrated decoction obtained by decocting in step (3) at 70 ℃ is 1.06-1.10.

Compared with the prior art, the invention has the beneficial effects that:

(1) dispelling wind and removing dampness, removing arthralgia and removing toxin, and eliminating pain:

the Chinese yam is matched with two good rheumatism dispelling products of ricefield eel vine and caulis sinomenii, so that the arthralgia-syndrome caused by invasion of wind, cold, dampness and evil is eliminated, the pain root of rheumatism bone is cut off, and the symptoms of pain, red swelling, morning stiffness and the like of the affected part are thoroughly eliminated.

(2) Repairing joints and dredging stasis:

the limited components of the rare Chinese herbal medicines in the formula, such as the alpinia japonica, the clematis root, the wakame, the philippine flemingia root, the spatholobus stem in Fengcheng and the like, can quickly repair the damaged joints, enhance the blood circulation of the affected parts, dredge the stasis and restore the normal physiological function.

(3) Enhancing immunity and avoiding relapse:

the combination of a plurality of traditional Chinese medicines such as gastrodia elata, codonopsis pilosula, astragalus mongholicus, jujube kernels, wolfberry fruits and the like greatly improves the immunity of a human body when expelling wind-damp, and further accelerates the curative effect of expelling wind-damp.

Detailed Description

The following further describes the embodiments of the present invention. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.

Example 1:

800g of Zuanshanfeng, 20g of four tiles, 110g of radix clematidis, 230g of philippine flemingia root, 200g of Fengcheng caulis spatholobi, 60g of alpinia japonica, 60g of rhizoma gastrodiae, 50g of codonopsis pilosula, 55g of astragalus mongholicus, 100g of jujube kernel and 40g of wolfberry fruit.

The preparation method comprises the following steps:

(1) chopping 20g of cleaned four-piece tile and 60g of alpinia japonica into coarse powder, percolating the coarse powder by using an ethanol solution with the mass fraction of 50% until the coarse powder is colorless, and collecting percolate for later use;

(2) cleaning raw materials including 800g of radix Fissistigmatis Oldhamii, 110g of radix Clematidis, 230g of radix Flemingiae Philippinensis and 200g of caulis Spatholobi, decocting separately for 2 times, each time for 2 hours, filtering each raw material to obtain filtrate, mixing the filtrates, concentrating until the relative density at 70 ℃ is 1.06, and cooling for later use;

(3) cleaning 60g of gastrodia elata, 50g of codonopsis pilosula, 55g of astragalus membranaceus, 100g of jujube kernel and 40g of wolfberry fruit serving as raw materials, respectively decocting for 2 times, 1.5 hours each time, filtering each raw material to obtain filtrate, mixing the filtrate, concentrating until the relative density at 70 ℃ is 1.06, and cooling for later use;

(4) mixing the liquids obtained in the steps (1) to (3), uniformly stirring, standing for 48 hours, filtering, adding water to 1000ml, stirring and filling;

(5) specification: each bottle contains 250 ml of the mixture, and each box contains 4 bottles;

(6) the usage and dosage are as follows: is administered orally. 20-30 ml for one time, 2-3 times a day, and shaking up when in use.

Example 2:

2000g of zuanshanfeng, 50g of four-piece tile, 50g of radix clematidis, 60g of philippine flemingia root, 80g of Fengcheng caulis spatholobi, 20g of alpinia japonica, 10g of rhizoma gastrodiae, 10g of codonopsis pilosula, 12g of astragalus mongholicus, 15g of jujube kernel and 5g of wolfberry fruit.

The preparation method comprises the following steps:

(1) chopping 50g of cleaned four-piece tile and 20g of alpinia japonica into coarse powder, percolating the coarse powder by using an ethanol solution with the mass fraction of 60% until the coarse powder is colorless, and collecting percolate for later use;

(2) cleaning 2000g of raw materials including radix Fissistigmatis Oldhamii, 50g of radix Clematidis, 60g of Moghania philippinensis and 80g of caulis Spatholobi, decocting separately for 3 times, each for 3 hours, filtering each raw material to obtain filtrate, mixing the filtrates, concentrating until the relative density at 70 ℃ is 1.07, and cooling for later use;

(3) cleaning 10g of gastrodia elata, 10g of codonopsis pilosula, 12g of astragalus membranaceus, 15g of jujube kernel and 5g of wolfberry fruit serving as raw materials, respectively decocting for 3 times and 2 hours each time, filtering each raw material to obtain filtrate, mixing the filtrate, concentrating until the relative density at 70 ℃ is 1.07, and cooling for later use;

Example 3:

The preparation method comprises the following steps:

(1) chopping 35g of cleaned four-piece tile and 45g of alpinia japonica into coarse powder, percolating the coarse powder by using an ethanol solution with the mass fraction of 70% until the coarse powder is colorless, and collecting percolate for later use;

(2) cleaning 1400g of raw materials including radix Fissistigmatis Oldhamii, 80g of radix Clematidis, 160g of Moghania philippinensis and 150g of caulis Spatholobi, decocting separately for 4 times each for 4 hours, filtering each raw material to obtain filtrate, mixing the filtrates, concentrating until the relative density is 1.08 at 70 deg.C, and cooling for use;

(3) cleaning raw materials including 30g of gastrodia elata, 20g of codonopsis pilosula, 24g of astragalus membranaceus, 20g of jujube kernel and 10g of wolfberry fruit, decocting separately for 4 times and 3 hours each time, filtering each raw material to obtain filtrate, mixing the filtrate, concentrating until the relative density at 70 ℃ is 1.08, and cooling for later use;

Example 4:

1400g of Zuanshanfeng, 35g of four tiles, 80g of radix clematidis, 160g of philippine flemingia root, 150g of Fengcheng caulis spatholobi, 45g of alpinia japonica, 30g of rhizoma gastrodiae, 20g of codonopsis pilosula, 24g of astragalus mongholicus, 20g of jujube kernel, 10g of wolfberry fruit, 500g of sucrose and 3g of benzoic acid.

The preparation method comprises the following steps:

(2) cleaning 1400g of raw materials including radix Fissistigmatis Oldhamii, 80g of radix Clematidis, 160g of Moghania philippinensis and 150g of caulis Spatholobi, decocting separately for 4 times and 5 hours each time, filtering each raw material to obtain filtrate, mixing the filtrates, concentrating until the relative density at 70 ℃ is 1.08, and cooling for later use;

(3) cleaning raw materials including 30g of gastrodia elata, 20g of codonopsis pilosula, 24g of astragalus membranaceus, 20g of jujube kernel and 10g of wolfberry fruit, decocting separately for 4 times and 3 hours each time, filtering each raw material to obtain filtrate, mixing the filtrate, concentrating until the relative density at 70 ℃ is 1.09, and cooling for later use;

(4) mixing the liquids obtained in the steps (1) to (3), stirring uniformly, standing for 48 hours, and filtering;

(5) and (3) preparing monosaccharide from 500g of sucrose, adding the monosaccharide into the liquid obtained after filtration in the step (4), stirring, adding 3g of benzoic acid, adding water to 1000ml, stirring, filtering and filling to obtain the product.

Example 5:

800g of Zuanshanfeng, 20g of four tiles, 110g of radix clematidis, 230g of philippine flemingia root, 200g of Fengcheng caulis spatholobi, 60g of alpinia japonica, 60g of rhizoma gastrodiae, 50g of codonopsis pilosula, 55g of astragalus mongholicus, 100g of jujube kernel, 40g of wolfberry fruit, 43g of ricefield eel vine and 40g of caulis sinomenii.

The preparation method comprises the following steps:

(1) chopping 20g of cleaned four-piece tile and 60g of alpinia japonica into coarse powder, percolating the coarse powder by using an ethanol solution with the mass fraction of 80% until the coarse powder is colorless, and collecting percolate for later use;

Example 6:

2000g of zuanshanfeng, 50g of four-piece tile, 50g of radix clematidis, 60g of philippine flemingia root, 80g of fengcheng caulis spatholobi, 20g of alpinia japonica, 10g of rhizoma gastrodiae, 10g of codonopsis pilosula, 12g of astragalus mongholicus, 15g of jujube kernel, 5g of wolfberry fruit, 23g of ricefield eel vine and 20g of caulis sinomenii.

The preparation method comprises the following steps:

(1) chopping 50g of cleaned four-piece tile and 20g of alpinia japonica into coarse powder, percolating the coarse powder by using an ethanol solution with the mass fraction of 80% until the coarse powder is colorless, and collecting percolate for later use;

(3) cleaning 10g of gastrodia elata, 10g of codonopsis pilosula, 12g of astragalus membranaceus, 15g of jujube kernel and 5g of wolfberry fruit, decocting separately for 3 times and 2 hours each time, filtering each raw material to obtain filtrate, mixing the filtrate, concentrating until the relative density at 70 ℃ is 1.10, and cooling for later use;

Example 7:

1400g of Zuanshanfeng, 35g of four tiles, 80g of radix clematidis, 160g of philippine flemingia root, 150g of Fengcheng caulis spatholobi, 45g of alpinia japonica, 30g of rhizoma gastrodiae, 20g of codonopsis pilosula, 24g of astragalus mongholicus, 20g of jujube kernel, 10g of wolfberry fruit, 33g of ricefield eel vine and 30g of caulis sinomenii.

The preparation method comprises the following steps:

Example 8:

1400g of Zuanshanfeng, 35g of four tiles, 80g of radix clematidis, 160g of philippine flemingia root, 150g of Fengcheng caulis spatholobi, 45g of alpinia japonica, 30g of rhizoma gastrodiae, 20g of codonopsis pilosula, 24g of astragalus mongholicus, 20g of jujube kernel, 10g of wolfberry fruit, 33g of ricefield eel vine, 30g of caulis sinomenii, 500g of sucrose and 3g of benzoic acid.

The preparation method comprises the following steps:

Comparative example:

the Zuanshanfeng syrup comprises the following raw materials in parts by weight:

1000g of Zuanshanfeng, 63g of Berchemia gambir, 25g of Sichuwa, 125g of Moghania philippinensis, 125g of Fengcheng caulis Spatholobi, 30g of alpinia japonica and 63g of radix Clematidis.

The preparation method comprises the following steps:

pulverizing the four tiles and the alpinia japonica into coarse powder, infiltrating deer with 50% of white spirit containing ethanol until the deer is colorless, and collecting deer infiltration liquid for later use. Decocting the rest five materials with water twice, each for 3 hr, mixing decoctions, concentrating to relative density of 1.06-1.10(70 deg.C), cooling, adding into the above percolate, stirring, standing for 48 hr, filtering, adding 500g sucrose with monosaccharide thickness, stirring, adding 2g benzoic acid, diluting to 1000ml, stirring, and filtering.

In order to show the treatment effect of the invention, the formula of the embodiment is adopted, the comparative example is taken as a control group, 100 cases of rheumatoid and rheumatoid arthritis patients are respectively clinically observed, and the specific results are as follows:

1. clinical data:

495 patients with rheumatoid and rheumatic arthritis were averagely divided into 9 groups, 8 of which were treated with Zuanshanfeng mixture, and the other was treated with Zuanshanfeng syrup. The basic condition of each treatment group was identical, namely 55 cases, 30 men and 25 women, the age period was 20-60 years, and the course of disease was 1 week-1 year.

2. The treatment method comprises the following steps:

(1) zuanshanfeng mixture treatment group: the Zuanshanfeng mixture of examples 1-8 is orally administered 20-30 ml each time 2-3 times a day for 1 treatment course, and 3 weeks for 1 treatment course.

(2) Zuanshanfeng syrup treatment control group: the Zuanshanfeng syrup is orally taken, 30ml is taken once, 2-3 times a day, 1 treatment course, and 3 weeks are 1 treatment course.

3. Diagnostic criteria:

the traditional Chinese medicine diagnosis is based on the guiding principle of clinical research of new traditional Chinese medicines; the western medicine diagnosis is determined according to the diagnosis standard of rheumatic arthritis and rheumatoid arthritis revised by the national conference of Chinese and western medicine combined with the academic conference of rheumatic diseases.

4. The curative effect standard is as follows:

and (3) curing: the symptoms are completely disappeared, the functional activities are recovered to be normal, and the main western medicine physical and chemical inspection indexes are normal;

the effect is shown: all symptoms are eliminated or main symptoms are eliminated, the joint function is basically recovered, the normal work or labor can be realized, and the physicochemical inspection indexes are normal;

the method has the following advantages: the main symptoms basically disappear, the joint function is basically recovered, the life can be self-managed, and the main physical and chemical examination indexes are improved;

and (4) invalidation: and no change before treatment.

5. The treatment effect is as follows:

the treatment effect of the nine groups is shown in the attached table:

	group of	Number of examples	Recovery method	Show effect	Is effective	Invalidation	Total effective rate
								Example 1	Zuanshanfeng mixture treatment group	55	8	15	27	5	90.91％
Example 2	Zuanshanfeng mixture treatment group	55	15	19	18	3	94.55％
								Example 3	Zuanshanfeng mixture treatment group	55	18	25	11	1	98.18％
Example 4	Zuanshanfeng mixture treatment group	55	20	20	14	1	98.18％
								Example 5	Zuanshanfeng mixture treatment group	55	7	15	27	6	89.09％
Example 6	Zuanshanfeng mixture treatment group	55	14	19	17	5	90.91％
								Example 7	Zuanshanfeng mixture treatment group	55	20	18	16	1	98.18％
Example 8	Zuanshanfeng mixture treatment group	55	21	21	13	0	100.00％
								Comparative example	Radix Fissistigmatis Oldhamii syrup treatment control group	55	7	18	20	10	81.82％

The embodiments of the present invention have been described in detail, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, and the scope of protection is still within the scope of the invention.

Claims

1. The Zuanshanfeng mixture is characterized by comprising the following components in parts by weight:

800-2000g of zuanshanfeng, 20-50g of four-piece tile, 50-110g of radix clematidis, 60-230g of philippine flemingia root, 80-200g of Fengcheng caulis spatholobi, 20-60g of alpinia japonica, 10-60g of rhizoma gastrodiae, 10-50g of codonopsis pilosula, 12-55g of astragalus mongholicus, 15-100g of jujube kernel, 5-40g of wolfberry fruit, 23-43g of finless eel stem, 20-40g of orientvine stem, 500g of sucrose and 3g of benzoic acid.

2. The Zuanshanfeng mixture as claimed in claim 1, which is prepared from the following components in parts by weight: