CN107456923A - One kind rolling dry granulating machine lever constant-voltage equipment - Google Patents

One kind rolling dry granulating machine lever constant-voltage equipment Download PDF

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Publication number
CN107456923A
CN107456923A CN201610390748.6A CN201610390748A CN107456923A CN 107456923 A CN107456923 A CN 107456923A CN 201610390748 A CN201610390748 A CN 201610390748A CN 107456923 A CN107456923 A CN 107456923A
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CN
China
Prior art keywords
pinch roller
lever
constant
granulating machine
dry granulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201610390748.6A
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Chinese (zh)
Inventor
刘海
余国华
朱亚东
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Special Science And Technology Ltd In Xinyi Shenzhen
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Special Science And Technology Ltd In Xinyi Shenzhen
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Application filed by Special Science And Technology Ltd In Xinyi Shenzhen filed Critical Special Science And Technology Ltd In Xinyi Shenzhen
Priority to CN201610390748.6A priority Critical patent/CN107456923A/en
Publication of CN107456923A publication Critical patent/CN107456923A/en
Withdrawn legal-status Critical Current

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/22Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by pressing in moulds or between rollers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses one kind to roll dry granulating machine lever constant-voltage equipment, and its structure includes pinch roller 1, pinch roller 2, pressurized cylinder, lever, fulcrum.The lever constant-voltage equipment that the present invention designs, constant pressure and lever design is fully utilized, solve the hardware deficiency and technical deficiency of existing rolling dry granulating machine, specific implementation is, constant pressure is provided using pressurized cylinder, and act on lever, upper and lower displacement occurs for one pinch roller of lever drives, or left and right displacement, the voluntarily spacing between adjustment and another pinch roller, so as to ensure that pinch roller constant pressure, it completely avoid and be not molded or overmolding phenomenon, save material, save the time, pinch roller " locking " phenomenon will not occur, particle compactness is homogeneous, the particle diameter distribution of particle can reappear completely, the dissolution rate of finished product/release favorable reproducibility, difference is small in batch, differences between batches are small, final product quality is completely secured.

Description

One kind rolling dry granulating machine lever constant-voltage equipment
Technical field
The present invention relates to one kind to roll dry granulating machine lever constant-voltage equipment, more particularly, to rolls dry granulating machine pinch roller constant-pressure structure, belongs to field of pharmaceutical equipment.
Background technology
At present; in pharmaceutical field; often pharmaceutical preparation product, chemical products, material science product, food etc. are pelletized using dry granulation mode; so as to reach the purpose that a step prepares dry particle; it is especially prominent in the application of pharmaceutical field; dry granulation is to be well mixed the powder of medicine and auxiliary material, after being compressed into big sheet, tabular or runner shape, is ground into the method for needing size particles.Relative to the wet granulation of routine, dry granulation has many advantages:1. it is low to consume energy, it is not necessary to which particle is thermally dried;2. it is with short production cycle, without secondary granulation, can directly filling capsule, or for tabletting;3. production efficiency is high, continuous production meets the throughput requirements of various scales;4. have using the stability for improving medicine, the production of the labile drug degradable especially suitable for thermo-responsive material, chance water.
Dry granulation is different according to pressing principle, can be divided into double compression granulation and rolling process granulation, double compression granulation, also known as dry-pressing granulation, dry extrude grain, it is to be compacted solid powder in heavy-duty tabletting press first, turns into a diameter of 20-25mm piece embryo, is then broken into the particle of required granularity again.The technique has the drawback that:Unit interval output is small, low production efficiency, deficiency in economic performance, process controllability are poor, support that system is excessive, air and noise pollution are more, energy consumption is big, so seldom using pharmaceutical field at present.And rolling process granulation is then still being widely applied; rolling process is to utilize the gap between two scroll wheels of rotating speed identical; powder is pressed into the block of definite shape, its shape is decided by pinch roller surface condition with size, and a certain size particle is then broken into by granulator.Compared with double compression is pelletized, its is with the obvious advantage:Production capacity is big, process operability is strong, energy consumption is low, and pollution is few, has obtained quite being widely applied in pharmaceutical field.
At present, rolling dry granulating machine both domestic and external, however it remains design defect, i.e. realize extrusion forming by setting the spacing between two pinch rollers, can so produce problems:1. operability is poor, especially for the pharmaceutical development stage, without any parameter foundation, it is easy to causes compacting not to be molded, or overmolding phenomenon occurs;2. material is wasted, it is necessary to grope pressure parameter by adjusting repeatedly;3. lose time, it is easy to because charging rate is uncoordinated, and cause pinch roller " locking " phenomenon.Further critical disadvantage is can not to ensure the inherent quality of particle, such as:1. in hardness heterogeneity in particle compactness heterogeneity, that is, particle;2. the particle diameter distribution of particle can not reappear;3. dissolution rate/release of solid pharmaceutical preparation finished product is unqualified, batch interior difference is big, differences between batches are big, poor reproducibility, final product quality can not be ensured.
In order to solve as above problem, different degrees of modification has all been done to respective dry granulating machine by equipment manufacturing enterprise, but be difficult be fully solved in particle quality problems.
The content of the invention
The technical problems to be solved by the invention are to overcome the puck design defect of existing rolling dry granulating machine, there is provided a kind of lever constant-voltage equipment reasonable in design, simple in construction, with a high credibility.
In order to solve the above technical problems, the present invention proposes technical scheme is:The rolling dry granulating machine lever constant-voltage equipment, its structure include pinch roller 1, pinch roller 2, pressurized cylinder, lever, fulcrum.1 progress coaxial rotating of pinch roller, does not occur upper and lower displacement, or left and right displacement.While pinch roller 2 carries out coaxial rotating, constant pressure is provided by pressurized cylinder, and acts on lever, upper and lower displacement, or left and right displacement occur for lever drives pinch roller 2.
Compared with prior art, the present invention has advantages below:Pressurized cylinder provides constant pressure, and acts on lever, and upper and lower displacement, or left and right displacement occur for the one of pinch roller of lever drives, voluntarily the spacing between adjustment and another pinch roller, so as to ensure that pinch roller constant pressure.Specific advantage has:1. strong operability, especially for the pharmaceutical development stage, the pressure value reached is wanted in input, ensures constant pressure, it is entirely avoided is not molded or overmolding phenomenon;2. saving material, saving the time, do not influenceed completely by charging rate, pinch roller " locking " phenomenon will not occur;3. preferably ensure that particle inherent quality, particle compactness is homogeneous;4. the particle diameter distribution of particle can reappear completely;5. the dissolution rate of solid pharmaceutical preparation finished product/release favorable reproducibility, batch interior difference is small, differences between batches are small, final product quality is completely secured.
Brief description of the drawings
Fig. 1, for the upper and lower pressure roller structure schematic diagram of the present invention.
Marginal data.
Upper pressure wheel, 2- lower pressure wheels, 3- pressurized cylinders, 4- levers, 5- fulcrums.
Fig. 2, for the left and right pressure roller structure structural representation of the present invention.
Marginal data.
The left pinch rollers of 1-, the right pinch rollers of 2-, 3- pressurized cylinders, 4- levers, 5- fulcrums.
Embodiment
The embodiment of the present invention is described in detail below in conjunction with accompanying drawing.It should be appreciated that embodiment described herein is merely to illustrate and explain the present invention, it is not intended to limit the invention.
Embodiment one.
With reference to accompanying drawing 1, according to a kind of rolling dry granulating machine lever constant-voltage equipment of the present invention, it is made up of 1- upper pressure wheels, 2- lower pressure wheels, 3- pressurized cylinders, 4- levers, 5- fulcrums.
2- lower pressure wheels only carry out coaxial rotating, and upper and lower displacement does not occur.
While 1- upper pressure wheels carry out coaxial rotating, it may occur that upper and lower displacement.
3- pressurized cylinders provide constant pressure, and act on 4- levers, and upper and lower displacement occurs for 4- lever drives 1- upper pressure wheels, voluntarily the spacing between adjustment and lower pressure wheel, so as to ensure that pinch roller constant pressure.
Formula:Aspirin 1kg, starch 120g, microcrystalline cellulose 120g.
Unit type:Mini-DC dry granulating machines.
After feeding intake, pressure 30kN is set, because material compressibility is bad, upper lower pressure wheel spacing can be with charging speed adjustment, and the constant pressure kept between two pinch rollers is 30kN ± 3N.
Embodiment two.
With reference to accompanying drawing 2, according to a kind of rolling dry granulating machine lever constant-voltage equipment of the present invention, it is made up of the left pinch rollers of 1-, the right pinch rollers of 2-, 3- pressurized cylinders, 4- levers, 5- fulcrums.
The left pinch rollers of 2- only carry out coaxial rotating, and left and right displacement does not occur.
While the right pinch rollers of 1- carry out coaxial rotating, it may occur that left and right displacement.
3- pressurized cylinders provide constant pressure, and act on 4- levers, and left and right displacement occurs for the right pinch rollers of 4- lever drives 1-, voluntarily the spacing between adjustment and left pinch roller, so as to ensure that pinch roller constant pressure.
Formula:Aspirin 1kg, starch 120g, microcrystalline cellulose 120g.
Unit type:DC-5 dry granulating machines.
After feeding intake, pressure 30kN is set, because material compressibility is bad, upper lower pressure wheel spacing can be with charging speed adjustment, and the constant pressure kept between two pinch rollers is 30kN ± 3N.
Although the present invention is disclosed as above with preferred embodiment; but it is not for limiting the present invention in fact; any those skilled in the art are without departing from the spirit and scope of the present invention; possible variation and modification can be made, therefore protection scope of the present invention should be defined by the scope that the claims in the present invention are defined.

Claims (1)

1. one kind rolling dry granulating machine lever constant-voltage equipment; its structure includes pinch roller 1, pinch roller 2, pressurized cylinder, lever, fulcrum; characterized in that, 1 progress coaxial rotating of pinch roller, does not occur upper and lower displacement; or left and right displacement; and while the progress coaxial rotating of pinch roller 2, constant pressure is provided by pressurized cylinder, and act on lever; upper and lower displacement, or left and right displacement occur for lever drives pinch roller 2.
CN201610390748.6A 2016-06-06 2016-06-06 One kind rolling dry granulating machine lever constant-voltage equipment Withdrawn CN107456923A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610390748.6A CN107456923A (en) 2016-06-06 2016-06-06 One kind rolling dry granulating machine lever constant-voltage equipment

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610390748.6A CN107456923A (en) 2016-06-06 2016-06-06 One kind rolling dry granulating machine lever constant-voltage equipment

Publications (1)

Publication Number Publication Date
CN107456923A true CN107456923A (en) 2017-12-12

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Application Number Title Priority Date Filing Date
CN201610390748.6A Withdrawn CN107456923A (en) 2016-06-06 2016-06-06 One kind rolling dry granulating machine lever constant-voltage equipment

Country Status (1)

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CN (1) CN107456923A (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105536649A (en) * 2016-01-23 2016-05-04 安徽环态生物能源科技开发有限公司 External press roll type granulation machine
CN206577727U (en) * 2016-06-06 2017-10-24 深圳市信宜特科技有限公司 One kind rolling dry granulating machine lever constant-voltage equipment

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105536649A (en) * 2016-01-23 2016-05-04 安徽环态生物能源科技开发有限公司 External press roll type granulation machine
CN206577727U (en) * 2016-06-06 2017-10-24 深圳市信宜特科技有限公司 One kind rolling dry granulating machine lever constant-voltage equipment

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Application publication date: 20171212

WW01 Invention patent application withdrawn after publication