CN107456522A - A kind of Chinese medicine for treating rhinitis tablet and preparation method thereof - Google Patents
A kind of Chinese medicine for treating rhinitis tablet and preparation method thereof Download PDFInfo
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- CN107456522A CN107456522A CN201710687612.6A CN201710687612A CN107456522A CN 107456522 A CN107456522 A CN 107456522A CN 201710687612 A CN201710687612 A CN 201710687612A CN 107456522 A CN107456522 A CN 107456522A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2063—Proteins, e.g. gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The present invention relates to field of medicaments, more particularly to a kind of Chinese medicine for treating rhinitis tablet and its manufacture craft, the Chinese medicinal tablet is made up of the raw material of following parts by weight：220 235 parts of stir-baked FRUCCTUS XANTHII, 160 168 parts of the flower bud of lily magnolia, 31 34 parts of asarum, 31 34 parts of the root of Dahurain angelica, 31 34 parts of radix scutellariae, 43 45 parts of bulbus fritillariae cirrhosae, 43 45 parts of Fermented Soybean, 34 parts of menthol, 14 16 parts of light magnesium oxide, 125 140 parts of sucrose, 23 parts of magnesium stearate, 95 105 parts of talcum powder, 0.7 0.8 parts of gelatin, light green 0.017 0.022 parts, 0.21 0.23 parts of insect wax.The technique includes preparation, granulation, drying, whole grain, total mixed, tabletting and the enrobing processes of crude drug processing, pulverizing medicinal materials, extraction concentration, simple syrup preparation, menthol and volatile oil.The tablet can effectively treat rhinitis, and menthol is well mixed with volatile oil, and tabletting effect is good, reduce pollution section, it is ensured that product quality, reduce labor intensity, improve production efficiency.
Description
Technical field
The present invention relates to field of medicaments, more particularly to a kind of Chinese medicine for treating rhinitis tablet and preparation method thereof.
Background technology
Rhinitis is schneiderian membrance or sub-mucosal tissues because viral infection, courses of infection, stimulant stimulation etc., cause schneiderian membrance
Or sub-mucosal tissues are damaged, caused acute or chronic inflammation.Rhinitis causes to produce excessive mucus, generally causes runny nose, nose
Symptom after the symptoms such as plug, especially patients with rhinitis appearance flu is very uncomfortable, and the medicine of existing treatment rhinitis is mostly spray, so
And spray excitant is larger, patients with rhinitis is very inconvenient using spray in public, and the medicine of existing treatment rhinitis is controlled
Therapeutic effect is bad, high recurrence rate, the complex manufacturing technology of medicine, and manufacturing process environmental pollution is more serious, and quality cannot be guaranteed,
And labor intensity is big, cost is higher, and yield is low.
The content of the invention
In view of the deficienciess of the prior art, the invention provides a kind of Chinese medicine for treating rhinitis tablet and its make work
Skill, the Chinese medicine preparation can effectively treat rhinitis, and menthol is blended in after room temperature is down in dry end with volatile oil and added, avoids
Mixed caused by always mixing uneven, and tabletting effect has clear improvement.Reduce pollution section, it is ensured that product quality,
Labor intensity is reduced, improves production efficiency.
The technical proposal of the invention is realized in this way：A kind of Chinese medicine for treating rhinitis tablet, by following parts by weight
Raw material forms：Stir-baked FRUCCTUS XANTHII 220-235 parts, flower bud of lily magnolia 160-168 parts, asarum 31-34 parts, root of Dahurain angelica 31-34 parts, radix scutellariae 31-34 parts,
Bulbus fritillariae cirrhosae 43-45 parts, Fermented Soybean 43-45 parts, menthol 3-4 parts, light magnesium oxide 14-16 parts, sucrose 125-140 parts are stearic
Sour magnesium 2-3 parts, talcum powder 95-105 parts, gelatin 0.7-0.8 parts, light green 0.017-0.022 parts, insect wax 0.21-0.23 parts.
Preferably, it is made up of the raw material of following parts by weight：223.2 parts of stir-baked FRUCCTUS XANTHII, 165.6 parts of the flower bud of lily magnolia, asarum 33.1
Part, 33.1 parts of the root of Dahurain angelica, 33.1 parts of radix scutellariae, 44.6 parts of bulbus fritillariae cirrhosae, 44.6 parts of Fermented Soybean, 3.53 parts of menthol, light magnesium oxide
14.4 parts, 130 parts of sucrose, 2 parts of magnesium stearate, 100 parts of talcum powder, 0.8 part of gelatin, light green 0.02 part, 0.22 part of insect wax.
The preparation method of a kind of Chinese medicine for treating rhinitis tablet, comprises the following steps：
Step 1：Feedstock treating
The flower bud of lily magnolia, asarum, the root of Dahurain angelica, radix scutellariae, bulbus fritillariae cirrhosae, Fermented Soybean are cleaned, by the flower bud of lily magnolia after cleaning, Fermented Soybean, bulbus fritillariae cirrhosae,
Weigh, enter net material storehouse；After the drinking water of asarum, the root of Dahurain angelica, radix scutellariae flowing is cleaned, segment in reciprocating medicine cutter is put into；Will
The radix scutellariae of cutting is placed in digester, is steamed 30 minutes；
By the asarum after cutting, the root of Dahurain angelica, the radix scutellariae loading a heatable brick bed car after moistening is steamed, it is 3~5cm to spread thickness, puts heated-air circulation oven
Middle drying, asarum are dried 4~6 hours in 40 ± 5 DEG C, and the root of Dahurain angelica is dried 3~5 hours in 55 ± 5 DEG C, and radix scutellariae dries 4 in 55 ± 5 DEG C
~6 hours, dried asarum, the root of Dahurain angelica, radix scutellariae moisture were no more than 12%, and outlet packs respectively after letting cool to room temperature；Claim
Weight, enter net material storehouse.
Sterilizing：The root of Dahurain angelica, bulbus fritillariae cirrhosae, the net medicinal material of Fermented Soybean are uniformly laid down into sterilization basket, are then put into sterilization basket wet
In thermal sterilization pot, between 0.1-0.3Mpa, 115 DEG C of temperature sterilizes 45 minutes control steam pressure；
Step 2：Pulverizing medicinal materials
Dry：The root of Dahurain angelica, bulbus fritillariae cirrhosae, Fermented Soybean after radix scutellariae and sterilizing are put in heated-air circulation oven and dried, it is 80 DEG C to set temperature,
Dry 8~12 hours；It is 80 DEG C that stir-baked FRUCCTUS XANTHII, which sets temperature, is dried 3~5 hours；Control moisture≤5%；
Stir-baked FRUCCTUS XANTHII is placed in pulverizer, crosses 20 mesh sieves, coarse powder is ground into, after crushing terminates, coarse powder is deposited in into clean appearance
In device, weigh, achene of Siberian cocklebur coarse powder yield >=98%, stick middle product label, be transferred to intermediate station；
The dried root of Dahurain angelica, bulbus fritillariae cirrhosae, Fermented Soybean, radix scutellariae are weighed by the parts by weight in claim 1；
Bulbus fritillariae cirrhosae after weighing, radix scutellariae, the root of Dahurain angelica, Fermented Soybean are placed in pulverizer and carry out co-grinding, 80 mesh sieves is crossed, is ground into
Former powder, after crushing terminates, former powder is fitted into clean container, weighed, examined, former powder yield >=97%；
Above-mentioned former powder is added in two-dimensional mixing machine, mixed 20 minutes, it is to be mixed uniformly after, be fitted into double-deck cleaning bag, tighten
Sack, weigh；
Step 3：Extraction
Weigh in the stir-baked FRUCCTUS XANTHII coarse powder input extractor of step 2, added equivalent to grey by the parts by weight in claim 1
70% ethanol of 6 times of weight of ears or side handles of a utensil coarse powder, soak 1 hour, be heated to reflux 5 hours, filter, reclaim ethanol, decoction is standby；To filter
Slag adds the drinking water equivalent to 6 times of weight of achene of Siberian cocklebur coarse powder, decocts 2.5 hours, merges decoction twice and, into storage tank, obtains Siberian cocklebur
Sub- extract solution, mark are standby；
In the flower bud of lily magnolia input extractor weighed by the parts by weight in claim 1, the drink equivalent to 10 times of weight of the flower bud of lily magnolia is added
With water, soak 2 hours, steam distillation 4~6 hours, collect magnolia flower volatile oil, put in clean container, weigh, stick middle product
Label, stored at 2~10 DEG C, it is standby；
Dried asarum in step 1 is weighed by the parts by weight in claim 1 to put into extractor, is added equivalent to thin
The drinking water of pungent 10 times of weight, soak 2 hours, steam distillation 4~6 hours, collect Herba Asari volatile oil, put in clean container,
Weigh, stick middle product label, stored at 2~10 DEG C, it is standby；
Step 4：Concentration
By the extract solution in step 3 by pipeline input dual-effect concentrator in concentrated, steam pressure be 0.01~
0.09MPa, it be 0.05~0.07MPa to control I effect vacuum, 70~80 DEG C of temperature, control II imitate vacuum for 0.06~
0.08MPa, 60~70 DEG C of temperature, is condensed into medicinal extract, is sent to by pipeline and receives cream tank, and adjustment medicinal extract is relatively close at 70 DEG C
Spend for 1.20~1.25, receive cream, medicinal extract is fitted into clean stainless steel cask, weighed, be capped, let cool to room temperature, stick middle product
Label, enter refrigeration house storage, standby, medicinal extract yield >=10%；
Step 5：It is prepared by simple syrup
Sucrose is weighed by the parts by weight in claim 1, sucrose is added in boiled water and dissolved, continues to heat and is stirred continuously
The simple syrup that 60-65% is made in nodeless mesh is all dissolved to sucrose, it is standby；
Step 6：The preparation of menthol and volatile oil
Dissolved by the menthol that the parts by weight in claim 1 weigh with 95% ethanol, 95% ethanol by weight proportion：Menthol
=2.5:3.53, menthol solution is made, then the Herba Asari volatile oil with being extracted in step 3 and magnolia flower volatile oil are well mixed, it is standby
With；
Step 7：Granulation, dry
The former powder that step 2 obtains, the light magnesium oxide addition trough type mixing machine weighed by the parts by weight in claim 1 are taken,
After dry-mixing 3~5 minutes, the obtained medicinal extract of step 4 is added and simple syrup that step 5 obtains, stir 2-4min, be well mixed
After discharge, obtain softwood, softwood inserted into oscillating granulator, softwood crosses 12 mesh sieves, particle is made；
Particle is sucked into fluidised bed granulator, goods fluid boiling, 20~30min is dried under the conditions of 45~60 DEG C, controls thing
Expect moisture be 3.0~5.0%, dry terminate after material is down to less than 30 DEG C, by the menthol prepared in step 6 with
Volatile oil mixed liquor adds the small in-car of transfusion and sprayed into particle, hydrojet 30~40Hz of frequency, after hydrojet terminates, discharging, will make
Good particle loads in clean container；
Step 8：Whole grain, always mix
The particle that step 7 obtains is subjected to whole grain by swing pelletizing machine with 12 mesh sieves, particle after whole grain and will by right
Ask the parts by weight magnesium stearate in 1 to add two-dimensional mixing machine, mix 20 minutes, load after well mixed in double-deck cleaning bag,
Sack is tightened, weighs, sticks middle product label, is examined.Always mixed material balance limit is 97~100%；
Step 8：Tabletting
Medicine tabletting after step 7 is always mixed with tablet press machine, tabletting is carried out by 0.3g/ pieces, sheeting process material balance limit is
97-100%；
Step 9：Coating
Plain piece after the compacting of step 8 is coated, packed after the assay was approved.
The present invention has advantages below：, should the invention discloses a kind of Chinese medicine for treating rhinitis tablet and preparation method thereof
Chinese medicine preparation can effectively treat nose using stir-baked FRUCCTUS XANTHII, the flower bud of lily magnolia, asarum, the root of Dahurain angelica, radix scutellariae, bulbus fritillariae cirrhosae, Fermented Soybean as crude drug
Inflammation, manufacture craft processing is rigorous, and menthol is blended in after room temperature is down in dry end with volatile oil and added, and avoids and is mixed always
Inequality is mixed caused by addition, and tabletting effect has clear improvement.Reduce pollution section, it is ensured that product quality, reduce work
Intensity, improve production efficiency.
Brief description of the drawings
Fig. 1 is the process chart of the present invention.
Embodiment
The embodiment of the present invention is further described below in conjunction with the accompanying drawings.
Embodiment 1：A kind of Chinese medicine for treating rhinitis tablet, it is made up of the raw material of following weight：Stir-baked FRUCCTUS XANTHII 220 Kg, it is pungent
Smooth 160 Kg, the Kg of asarum 31, the Kg of the root of Dahurain angelica 31, the Kg of radix scutellariae 31, the Kg of bulbus fritillariae cirrhosae 43, the Kg of Fermented Soybean 43, the Kg of menthol 3, gently
The Kg of matter magnesia 14, sucrose（Granulation is used）30 Kg, sucrose（Coating is used）95 Kg, the Kg of magnesium stearate 2, talcum powder 95 Kg are bright
Glue 0.7 Kg, light green 0.017 Kg, the Kg of insect wax 0.21.
The preparation method of a kind of Chinese medicine for treating rhinitis tablet, as shown in figure 1, comprising the following steps：
Step 1：Feedstock treating
Raw material is weighed by following weight：The Kg of stir-baked FRUCCTUS XANTHII 220, the Kg of the flower bud of lily magnolia 160, the Kg of asarum 31, the Kg of the root of Dahurain angelica 31, radix scutellariae 31
Kg, the Kg of bulbus fritillariae cirrhosae 43, the Kg of Fermented Soybean 43, the Kg of menthol 3, the Kg of light magnesium oxide 14, sucrose（Granulation is used）30 Kg, sucrose
（Coating is used）95 Kg, the Kg of magnesium stearate 2, the Kg of talcum powder 95, gelatin 0.7 Kg, light green 0.017 Kg, the Kg of insect wax 0.21；
| Title | Internal control quality standard | Middle controlling party Method |
| Fry Siberian cocklebur Son | This product is in spindle or oval, surface yellowish-brown, there is puneture.It is micro- aromatic. | Range estimation |
| The flower bud of lily magnolia | With flower bud of lily magnolia crude drug | Range estimation |
| The root of Dahurain angelica | This product is the irregular fragment of the root of Dahurain angelica.Exocuticle taupe brown or yellowish-brown.Section white, has mealiness, and cambium ring brown, closely square or subcircular, skin zone dissipate There are most brown oil drops.Gas fragrance, acrid flavour, slight bitter. | Range estimation |
| Asarum | This product is in irregular section.Rhizome is in irregular cycle, exocuticle taupe brown, sometimes visible annular section.Root is thin, surface lark, the vertical wrinkle of smooth or tool Line.Section yellow-white or white.The pungent perfume (or spice) of gas, acrid flavour is peppery, numb tongue. | Range estimation |
| Radix scutellariae | This product is similar round or irregular shape piece or section, exocuticle yellowish-brown or sepia, section yellowish-brown or yellow green, has radial texture. | Range estimation |
| Bulbus fritillariae cirrhosae | With bulbus fritillariae cirrhosae crude drug | Range estimation |
| Fermented Soybean | With Fermented Soybean crude drug | Range estimation |
The flower bud of lily magnolia, asarum, the root of Dahurain angelica, radix scutellariae, bulbus fritillariae cirrhosae, Fermented Soybean are cleaned, by the flower bud of lily magnolia after cleaning, Fermented Soybean, bulbus fritillariae cirrhosae,
Weigh, enter net material storehouse；After the drinking water of asarum, the root of Dahurain angelica, radix scutellariae flowing is cleaned, segment in reciprocating medicine cutter is put into；Will
The radix scutellariae of cutting is placed in digester, is steamed 30 minutes；
By the asarum after cutting, the root of Dahurain angelica, steam the radix scutellariae loading a heatable brick bed car after moistening（A heatable brick bed car is the corollary equipment of heated-air circulation oven）, stand
It is 3~5cm to put thickness, puts heated-air circulation oven（Wuxi City joint De Yi pharmaceutical equipments Co., Ltd, CT-C-II, a heatable brick bed car is it
Corollary equipment）Middle drying, asarum are dried 6 hours in 35 DEG C, and the root of Dahurain angelica is dried 5 hours in 50 DEG C, and radix scutellariae is dried 6 hours in 50 DEG C,
Dried asarum, the root of Dahurain angelica, radix scutellariae moisture are no more than 12%, and outlet packs respectively after letting cool to room temperature；Weigh, enter net
Expect storehouse.
Sterilizing：The root of Dahurain angelica, bulbus fritillariae cirrhosae, the net medicinal material of Fermented Soybean are uniformly laid down into sterilization basket, are then put into sterilization basket wet
Thermal sterilization pot (Zhucheng Yongtai Machinery Co., Ltd., R2013-326）In, control steam pressure is between 0.1-0.3Mpa, temperature
115 DEG C of degree sterilizes 45 minutes；
Step 2：Pulverizing medicinal materials
Dry：The root of Dahurain angelica, bulbus fritillariae cirrhosae, Fermented Soybean after radix scutellariae and sterilizing are put into heated-air circulation oven（Wuxi City joint moral skill pharmacy is set
Standby Co., Ltd, CT-C-II, a heatable brick bed car is its corollary equipment）Middle drying, it is 80 DEG C to set temperature, is dried 12 hours；Stir-baked FRUCCTUS XANTHII
It is 80 DEG C to set temperature, is dried 5 hours；Control moisture≤5%；
Stir-baked FRUCCTUS XANTHII is placed in pulverizer, crosses 20 mesh sieves, coarse powder is ground into, after crushing terminates, coarse powder is deposited in into clean appearance
In device, weigh, achene of Siberian cocklebur coarse powder yield >=98%, stick middle product label, be transferred to intermediate station；
Bulbus fritillariae cirrhosae, radix scutellariae, the root of Dahurain angelica, Fermented Soybean weighed by the parts by weight in step 1 be placed in pulverizer carry out co-grinding,
80 mesh sieves are crossed, former powder is ground into, after crushing terminates, former powder is fitted into clean container, weigh, examine, former powder yield >=97%；
Above-mentioned former powder is added into two-dimensional mixing machine（Jiangyin City, which runs quickly, reaches medicine mechanical equipment factory, EYH-1000）It is interior, mix 20 minutes,
It is to be mixed uniformly after, be fitted into double-deck cleaning bag, tighten sack, weigh；
Step 3：Extraction
Weighed by the parts by weight in step 1 in the stir-baked FRUCCTUS XANTHII coarse powder input extractor of step 2（Wenzhou City's chemical machinery
Factory, TQX-3-3m3）, 70% ethanol equivalent to 6 times of weight of achene of Siberian cocklebur coarse powder is added, soaks 1 hour, is heated to reflux 5 hours, mistake
Filter, reclaims ethanol, and decoction is standby；The drinking water equivalent to 6 times of weight of achene of Siberian cocklebur coarse powder is added to filter residue, is decocted 2.5 hours, is closed
And decoction into storage tank, obtains Fructus Xanthii extractive liquid twice, mark is standby；
Weighed by the parts by weight in step 1 in flower bud of lily magnolia input extractor, add the drinking water equivalent to 10 times of weight of the flower bud of lily magnolia,
Immersion 2 hours, steam distillation 4~6 hours, magnolia flower volatile oil is collected, is put in clean container, weighed, stick middle product label,
Hand over refrigeration house storage（2~10 DEG C）, it is standby；
Weigh in dried asarum input extractor, added equivalent to 10 times of weight of asarum by the parts by weight in step 1
Drinking water, soak 2 hours, steam distillation 6 hours, collect Herba Asari volatile oil, put in clean container, weigh, stick middle product
Label, hand over freezer（2~10 DEG C）Storage, it is standby；
Step 4：Concentration
Extract solution in step 3 is inputted into dual-effect concentrator (the strong chemical and medicine industry equipment limited public affairs of share of Anhui god by pipeline
Department, model：SJN02-2000 concentrated in), steam pressure 0.09MPa, it is 0.07MPa to control I effect vacuum, temperature
80 DEG C, it is 0.08MPa to control II effect vacuum, temperature 70 C, is condensed into medicinal extract, is sent to by pipeline and receives cream tank, adjustment leaching
Relative density of the cream at 70 DEG C is 1.20~1.25, receives cream, medicinal extract is fitted into clean stainless steel cask, weighed, and is capped, lets cool
To room temperature, middle product label is sticked, enters refrigeration house storage, standby, medicinal extract yield >=10%；
Step 5：It is prepared by simple syrup
Weigh sucrose by the parts by weight in step 1, will sucrose add boiled water in dissolve, continue to heat and be stirred continuously to
Sucrose all dissolves the simple syrup that nodeless mesh is made 60%, standby；
Step 6：The preparation of menthol and volatile oil mixed liquor
Menthol is weighed by the parts by weight in step 1 to be dissolved with 95% ethanol, by weight proportion 95% ethanol：Menthol=2.5:
3.53, menthol solution is made, then the Herba Asari volatile oil with being extracted in step 3 and magnolia flower volatile oil are well mixed, it is standby；
Step 7：Granulation, dry
Former powder that step 2 obtains is taken, light magnesium oxide is weighed by the parts by weight in step 1 and adds trough type mixing machine (Jiangsu
Fan Qun drying equipments factory, CH200）, dry-mixing is after 5 minutes, adds the medicinal extract that step 4 obtains and the simple syrup that step 5 obtains,
4min is stirred, is discharged after well mixed, is obtained softwood, softwood is inserted into oscillating granulator（The positive Chinese medicine machine factory in Changsha,
YK-160）, softwood crosses 12 mesh sieves, particle is made；
Particle is sucked into fluidised bed granulator（Section of Chongqing City rising sun pharmaceutical machine equipment system, LGL-200.Dolly of infusing is that its is supporting
Equipment）, goods fluid boiling, 20min is dried under the conditions of 60 DEG C, control material moisture is 5.0%, and dry makes after terminating
Material is down to less than 30 DEG C, and the menthol prepared in step 6 and volatile oil mixed liquor are added into the small in-car of transfusion and penetrating
Intragranular, hydrojet 30~40Hz of frequency, after hydrojet terminates, discharging, the particle made is loaded in clean container；
Step 8：Whole grain, always mix
The particle that step 7 obtains is subjected to whole grain by swing pelletizing machine with 12 mesh sieves, particle after whole grain and by step 1
In parts by weight weigh magnesium stearate and add two-dimensional mixing machine, mix 20 minutes, load after well mixed in double-deck cleaning bag,
Sack is tightened, weighs, sticks middle product label, is examined；Always mixed material balance limit is 97%；
Step 8：Tabletting
Medicine tabletting after step 7 is always mixed with tablet press machine, tabletting, weight differential ± 4.5%, 0.2865- are carried out by 0.3g/ pieces
0.3135g, sheeting process material balance limit are 97%；
Step 9：Coating
Plain piece after the compacting of step 8 is coated, packed after the assay was approved.
Embodiment 2：A kind of Chinese medicine for treating rhinitis tablet, it is made up of the raw material of following weight：Stir-baked FRUCCTUS XANTHII 235 Kg, it is pungent
Smooth 168 Kg, the Kg of asarum 34, the Kg of the root of Dahurain angelica 34, the Kg of radix scutellariae 34, the Kg of bulbus fritillariae cirrhosae 45, the Kg of Fermented Soybean 45, the Kg of menthol 4, gently
The Kg of matter magnesia 16, the Kg of sucrose 35（Granulation is used）, the Kg of sucrose 105（Coating is used）, the Kg of magnesium stearate 3, the Kg of talcum powder 105,
Gelatin 0.8 Kg, light green 0.022 Kg, the Kg of insect wax 0.23.
The preparation method of a kind of Chinese medicine for treating rhinitis tablet, comprises the following steps：
Step 1：Feedstock treating
| Title | Internal control quality standard | Middle controlling party Method |
| Stir-baked FRUCCTUS XANTHII | This product is in spindle or oval, surface yellowish-brown, there is puneture.It is micro- aromatic. | Range estimation |
| The flower bud of lily magnolia | With flower bud of lily magnolia crude drug | Range estimation |
| The root of Dahurain angelica | This product is the irregular fragment of the root of Dahurain angelica.Exocuticle taupe brown or yellowish-brown.Section white, have mealiness, cambium ring brown, nearly square or subcircular, skin zone Dissipating has most brown oil drops.Gas fragrance, acrid flavour, slight bitter. | Range estimation |
| Asarum | This product is in irregular section.Rhizome is in irregular cycle, exocuticle taupe brown, sometimes visible annular section.Root is thin, surface lark, and smooth or tool is vertical Wrinkle.Section yellow-white or white.The pungent perfume (or spice) of gas, acrid flavour is peppery, numb tongue. | Range estimation |
| Radix scutellariae | This product is similar round or irregular shape piece or section, exocuticle yellowish-brown or sepia, section yellowish-brown or yellow green, has radial texture. | Range estimation |
| Bulbus fritillariae cirrhosae | With bulbus fritillariae cirrhosae crude drug | Range estimation |
| Fermented Soybean | With Fermented Soybean crude drug | Range estimation |
Raw material is weighed by following weight：The Kg of stir-baked FRUCCTUS XANTHII 235, the Kg of the flower bud of lily magnolia 168, the Kg of asarum 34, the Kg of the root of Dahurain angelica 34, radix scutellariae 34
Kg, the Kg of bulbus fritillariae cirrhosae 45, the Kg of Fermented Soybean 45, the Kg of menthol 4, the Kg of light magnesium oxide 16, the Kg of sucrose 35（Granulation is used）, sucrose
105 Kg（Coating is used）, the Kg of magnesium stearate 3, the Kg of talcum powder 105, gelatin 0.8 Kg, light green 0.022 Kg, insect wax 0.23
Kg。
The flower bud of lily magnolia, asarum, the root of Dahurain angelica, radix scutellariae, bulbus fritillariae cirrhosae, Fermented Soybean are cleaned, by the flower bud of lily magnolia after cleaning, Fermented Soybean, river
Fritillaria, weigh, enter net material storehouse；After the drinking water of asarum, the root of Dahurain angelica, radix scutellariae flowing is cleaned, it is put into reciprocating medicine cutter and cuts
Section；The radix scutellariae of cutting is placed in digester, steamed 30 minutes；
By the asarum after cutting, the root of Dahurain angelica, steam the radix scutellariae loading a heatable brick bed car after moistening（A heatable brick bed car is the corollary equipment of heated-air circulation oven）, stand
It is 3~5cm to put thickness, puts heated-air circulation oven（Wuxi City joint De Yi pharmaceutical equipments Co., Ltd, CT-C-II, a heatable brick bed car is it
Corollary equipment）Middle drying, asarum are dried 4 hours in 45 DEG C, and the root of Dahurain angelica is dried 3 hours in 60 DEG C, and radix scutellariae is dried 4 hours in 60 DEG C,
Dried asarum, the root of Dahurain angelica, radix scutellariae moisture are no more than 12%, and outlet packs respectively after letting cool to room temperature；Weigh, enter net
Expect storehouse；
Sterilizing：The root of Dahurain angelica, bulbus fritillariae cirrhosae, the net medicinal material of Fermented Soybean are uniformly laid down into sterilization basket, sterilization basket is then put into damp and hot kill
Bacterium pot (Zhucheng Yongtai Machinery Co., Ltd., R2013-326）In, control steam pressure is between 0.1-0.3Mpa, temperature 115
DEG C sterilizing 45 minutes；
Step 2：Pulverizing medicinal materials
Dry：The root of Dahurain angelica, bulbus fritillariae cirrhosae, Fermented Soybean after radix scutellariae and sterilizing are put into heated-air circulation oven（Wuxi City joint moral skill pharmacy is set
Standby Co., Ltd, CT-C-II, a heatable brick bed car is its corollary equipment）Middle drying, it is 80 DEG C to set temperature, is dried 8 hours；Stir-baked FRUCCTUS XANTHII
It is 80 DEG C to set temperature, is dried 3 hours；Control moisture≤5%；
Stir-baked FRUCCTUS XANTHII is placed in pulverizer, crosses 20 mesh sieves, coarse powder is ground into, after crushing terminates, coarse powder is deposited in into clean appearance
In device, weigh, achene of Siberian cocklebur coarse powder yield >=98%, stick middle product label, be transferred to intermediate station；
Bulbus fritillariae cirrhosae, radix scutellariae, the root of Dahurain angelica, Fermented Soybean weighed by the parts by weight in step 1 be placed in pulverizer carry out co-grinding,
80 mesh sieves are crossed, former powder is ground into, after crushing terminates, former powder is fitted into clean container, weigh, examine, former powder yield >=97%；
Above-mentioned former powder is added into two-dimensional mixing machine（Jiangyin City, which runs quickly, reaches medicine mechanical equipment factory, EYH-1000）It is interior, mix 20 minutes,
It is to be mixed uniformly after, be fitted into double-deck cleaning bag, tighten sack, weigh.
Step 3：Extraction
Weighed by the parts by weight in step 1 in the stir-baked FRUCCTUS XANTHII coarse powder input extractor of step 2（Wenzhou City's chemical machinery
Factory, TQX-3-3m3）, 70% ethanol equivalent to 6 times of weight of achene of Siberian cocklebur coarse powder is added, soaks 1 hour, is heated to reflux 5 hours, mistake
Filter, reclaims ethanol, and decoction is standby；The drinking water equivalent to 6 times of weight of achene of Siberian cocklebur coarse powder is added to filter residue, is decocted 2.5 hours, is closed
And decoction into storage tank, obtains Fructus Xanthii extractive liquid twice, mark is standby；
Weighed by the parts by weight in step 1 in flower bud of lily magnolia input extractor, add the drinking water equivalent to 10 times of weight of the flower bud of lily magnolia,
Immersion 2 hours, steam distillation 4 hours, magnolia flower volatile oil is collected, is put in clean container, weighed, stick middle product label, handed over
Refrigeration house storage（2~10 DEG C）, it is standby；
Weigh in dried asarum input extractor, added equivalent to 10 times of weight of asarum by the parts by weight in step 1
Drinking water, soak 2 hours, steam distillation 4 hours, collect Herba Asari volatile oil, put in clean container, weigh, stick middle product
Label, hand over freezer（2~10 DEG C）Storage, it is standby；
Step 4：Concentration
Extract solution in step 3 is inputted into dual-effect concentrator (the strong chemical and medicine industry equipment limited public affairs of share of Anhui god by pipeline
Department, model：SJN02-2000 concentrated in), steam pressure 0.01MPa, it is 0.05MPa to control I effect vacuum, temperature
70 DEG C, it is 0.06MPa to control II effect vacuum, temperature 60 C, is condensed into medicinal extract, is sent to by pipeline and receives cream tank, adjustment leaching
Relative density of the cream at 70 DEG C is 1.20~1.25, receives cream, medicinal extract is fitted into clean stainless steel cask, weighed, and is capped, lets cool
To room temperature, middle product label is sticked, enters refrigeration house storage, standby, medicinal extract yield >=10%；
Step 5：It is prepared by simple syrup
Weigh sucrose by the parts by weight in step 1, will sucrose add boiled water in dissolve, continue to heat and be stirred continuously to
Sucrose all dissolves the simple syrup that nodeless mesh is made 60%, standby；
Step 6：The preparation of menthol and volatile oil mixed liquor
Menthol is weighed by the parts by weight in step 1 to be dissolved with 95% ethanol, by weight proportion 95% ethanol：Menthol=2.5:
3.53, menthol solution is made, then the Herba Asari volatile oil with being extracted in step 3 and magnolia flower volatile oil are well mixed, it is standby；
Step 7：Granulation, dry
Former powder that step 2 obtains is taken, light magnesium oxide is weighed by the parts by weight in step 1 and adds trough type mixing machine (Jiangsu
Fan Qun drying equipments factory, CH200）, dry-mixing is after 3~5 minutes, adds the medicinal extract that step 4 obtains and the monose that step 5 obtains
Slurry, 2-4min is stirred, is discharged after well mixed, is obtained softwood, softwood is inserted into oscillating granulator（The positive Chinese medicine machine in Changsha
Factory, YK-160）, softwood crosses 12 mesh sieves, particle is made；
Particle is sucked into fluidised bed granulator（Section of Chongqing City rising sun pharmaceutical machine equipment system, LGL-200.Dolly of infusing is that its is supporting
Equipment）, goods fluid boiling, 30min is dried under the conditions of 45 DEG C, control material moisture is 3.0%, and dry makes after terminating
Material is down to less than 30 DEG C, and the menthol prepared in step 6 and volatile oil mixed liquor are added into the small in-car of transfusion and penetrating
Intragranular, hydrojet 30~40Hz of frequency, after hydrojet terminates, discharging, the particle made is loaded in clean container；
Step 8：Whole grain, always mix
The particle that step 7 obtains is subjected to whole grain by swing pelletizing machine with 12 mesh sieves, particle after whole grain and by step 1
In parts by weight weigh magnesium stearate and add two-dimensional mixing machine, mix 20 minutes, load after well mixed in double-deck cleaning bag,
Sack is tightened, weighs, sticks middle product label, is examined.Always mixed material balance limit is 99%；
Step 8：Tabletting
Medicine tabletting after step 7 is always mixed with tablet press machine, tabletting, weight differential ± 4.5%, 0.2865- are carried out by 0.3g/ pieces
0.3135g, sheeting process material balance limit are 98.5%；
Step 9：Coating
Plain piece after the compacting of step 8 is coated, packed after the assay was approved.
Embodiment 3：A kind of Chinese medicine for treating rhinitis tablet, it is made up of the raw material of following weight：The Kg of stir-baked FRUCCTUS XANTHII 223.2,
The Kg of the flower bud of lily magnolia 165.6, the Kg of asarum 33.1, the Kg of the root of Dahurain angelica 33.1, the Kg of radix scutellariae 33.1, the Kg of bulbus fritillariae cirrhosae 44.6, Fermented Soybean 44.6
Kg, the Kg of menthol 3.53, the Kg of light magnesium oxide 14.4, the Kg of sucrose 30（Granulation is used）, the Kg of sucrose 100（Coating is used）, it is stearic
The sour Kg of magnesium 2, the Kg of talcum powder 100, gelatin 0.8 Kg, light green 0.02 Kg, the Kg of insect wax 0.22.
The preparation method of a kind of Chinese medicine for treating rhinitis tablet, comprises the following steps：
Step 1：Feedstock treating
| Title | Internal control quality standard | Intermediate control methods |
| Stir-baked FRUCCTUS XANTHII | This product is in spindle or oval, surface yellowish-brown, there is puneture.It is micro- aromatic. | Range estimation |
| The flower bud of lily magnolia | With flower bud of lily magnolia crude drug | Range estimation |
| The root of Dahurain angelica | This product is the irregular fragment of the root of Dahurain angelica.Exocuticle taupe brown or yellowish-brown.Section white, have mealiness, cambium ring brown, nearly square or subcircular, skin zone Dissipating has most brown oil drops.Gas fragrance, acrid flavour, slight bitter. | Range estimation |
| Asarum | This product is in irregular section.Rhizome is in irregular cycle, exocuticle taupe brown, sometimes visible annular section.Root is thin, surface lark, and smooth or tool is vertical Wrinkle.Section yellow-white or white.The pungent perfume (or spice) of gas, acrid flavour is peppery, numb tongue. | Range estimation |
| Radix scutellariae | This product is similar round or irregular shape piece or section, exocuticle yellowish-brown or sepia, section yellowish-brown or yellow green, has radial texture. | Range estimation |
| Bulbus fritillariae cirrhosae | With bulbus fritillariae cirrhosae crude drug | Range estimation |
| Fermented Soybean | With Fermented Soybean crude drug | Range estimation |
Raw material is weighed by following weight：The Kg of stir-baked FRUCCTUS XANTHII 223.2, the Kg of the flower bud of lily magnolia 165.6, the Kg of asarum 33.1, the root of Dahurain angelica 33.1
Kg, the Kg of radix scutellariae 33.1, the Kg of bulbus fritillariae cirrhosae 44.6, the Kg of Fermented Soybean 44.6, the Kg of menthol 3.53, the Kg of light magnesium oxide 14.4, sugarcane
30 Kg of sugar（Granulation is used）, the Kg of sucrose 100（Coating is used）, the Kg of magnesium stearate 2, the Kg of talcum powder 100, gelatin 0.8 Kg is light green
0.02 Kg, the Kg of insect wax 0.22.
The flower bud of lily magnolia, asarum, the root of Dahurain angelica, radix scutellariae, bulbus fritillariae cirrhosae, Fermented Soybean are cleaned, by the flower bud of lily magnolia after cleaning, Fermented Soybean, river
Fritillaria, weigh, enter net material storehouse；After the drinking water of asarum, the root of Dahurain angelica, radix scutellariae flowing is cleaned, it is put into reciprocating medicine cutter and cuts
Section；The radix scutellariae of cutting is placed in digester, steamed 30 minutes；
By the asarum after cutting, the root of Dahurain angelica, steam the radix scutellariae loading a heatable brick bed car after moistening（A heatable brick bed car is the corollary equipment of heated-air circulation oven）, stand
It is 3~5cm to put thickness, puts heated-air circulation oven（Wuxi City joint De Yi pharmaceutical equipments Co., Ltd, CT-C-II, a heatable brick bed car is it
Corollary equipment）Middle drying, asarum are dried 5 hours in 40 DEG C, and the root of Dahurain angelica is dried 4 hours in 55 DEG C, and radix scutellariae is dried 5 hours in 55 DEG C,
Dried asarum, the root of Dahurain angelica, radix scutellariae moisture are no more than 12%, and outlet packs respectively after letting cool to room temperature；Weigh, enter net
Expect storehouse；
Sterilizing：The root of Dahurain angelica, bulbus fritillariae cirrhosae, the net medicinal material of Fermented Soybean are uniformly laid down into sterilization basket, sterilization basket is then put into damp and hot kill
Bacterium pot (Zhucheng Yongtai Machinery Co., Ltd., R2013-326）In, control steam pressure is between 0.1-0.3Mpa, temperature 115
DEG C sterilizing 45 minutes；
Step 2：Pulverizing medicinal materials
Dry：The root of Dahurain angelica, bulbus fritillariae cirrhosae, Fermented Soybean after radix scutellariae and sterilizing are put into heated-air circulation oven（Wuxi City joint moral skill pharmacy is set
Standby Co., Ltd, CT-C-II, a heatable brick bed car is its corollary equipment）Middle drying, it is 80 DEG C to set temperature, is dried 10 hours；Stir-baked FRUCCTUS XANTHII
It is 80 DEG C to set temperature, is dried 4 hours；Control moisture≤5%；
Stir-baked FRUCCTUS XANTHII is placed in pulverizer, crosses 20 mesh sieves, coarse powder is ground into, after crushing terminates, coarse powder is deposited in into clean appearance
In device, weigh, achene of Siberian cocklebur coarse powder yield >=98%, stick middle product label, be transferred to intermediate station；
Bulbus fritillariae cirrhosae, radix scutellariae, the root of Dahurain angelica, Fermented Soybean weighed by the parts by weight in step 1 be placed in pulverizer carry out co-grinding,
80 mesh sieves are crossed, former powder is ground into, after crushing terminates, former powder is fitted into clean container, weigh, examine, former powder yield >=97%；
Above-mentioned former powder is added into two-dimensional mixing machine（Jiangyin City, which runs quickly, reaches medicine mechanical equipment factory, EYH-1000）It is interior, mix 20 minutes,
It is to be mixed uniformly after, be fitted into double-deck cleaning bag, tighten sack, weigh.
Step 3：Extraction
Weighed by the parts by weight in step 1 in the stir-baked FRUCCTUS XANTHII coarse powder input extractor of step 2（Wenzhou City's chemical machinery
Factory, TQX-3-3m3）, 70% ethanol equivalent to 6 times of weight of achene of Siberian cocklebur coarse powder is added, soaks 1 hour, is heated to reflux 5 hours, mistake
Filter, reclaims ethanol, and decoction is standby；The drinking water equivalent to 6 times of weight of achene of Siberian cocklebur coarse powder is added to filter residue, is decocted 2.5 hours, is closed
And decoction into storage tank, obtains Fructus Xanthii extractive liquid twice, mark is standby；
Weighed by the parts by weight in step 1 in flower bud of lily magnolia input extractor, add the drinking water equivalent to 10 times of weight of the flower bud of lily magnolia,
Immersion 2 hours, steam distillation 4~6 hours, magnolia flower volatile oil is collected, is put in clean container, weighed, stick middle product label,
Hand over refrigeration house storage（2~10 DEG C）, it is standby；
Weigh in dried asarum input extractor, added equivalent to 10 times of weight of asarum by the parts by weight in step 1
Drinking water, soak 2 hours, steam distillation 5 hours, collect Herba Asari volatile oil, put in clean container, weigh, stick middle product
Label, hand over freezer（2~10 DEG C）Storage, it is standby；
Step 4：Concentration
Extract solution in step 3 is inputted into dual-effect concentrator (the strong chemical and medicine industry equipment limited public affairs of share of Anhui god by pipeline
Department, model：SJN02-2000 concentrated in), steam pressure 0.05MPa, it is 0.06MPa to control I effect vacuum, temperature
75 DEG C, it is 0.07MPa to control II effect vacuum, 65 DEG C of temperature, is condensed into medicinal extract, is sent to by pipeline and receives cream tank, adjustment leaching
Relative density of the cream at 70 DEG C is 1.20~1.25, receives cream, medicinal extract is fitted into clean stainless steel cask, weighed, and is capped, lets cool
To room temperature, middle product label is sticked, enters refrigeration house storage, standby, medicinal extract yield >=10%；
Step 5：It is prepared by simple syrup
Weigh sucrose by the parts by weight in step 1, will sucrose add boiled water in dissolve, continue to heat and be stirred continuously to
Sucrose all dissolves the simple syrup that nodeless mesh is made 63%, standby；
Step 6：The preparation of menthol and volatile oil mixed liquor
Menthol is weighed by the parts by weight in step 1 to be dissolved with 95% ethanol, by weight proportion 95% ethanol：Menthol=2.5:
3.53, menthol solution is made, then the Herba Asari volatile oil with being extracted in step 3 and magnolia flower volatile oil are well mixed, it is standby；
Step 7：Granulation, dry
Former powder that step 2 obtains is taken, light magnesium oxide is weighed by the parts by weight in step 1 and adds trough type mixing machine (Jiangsu
Fan Qun drying equipments factory, CH200）, dry-mixing is after 3~5 minutes, adds the medicinal extract that step 4 obtains and the monose that step 5 obtains
Slurry, 2-4min is stirred, is discharged after well mixed, is obtained softwood, softwood is inserted into oscillating granulator（The positive Chinese medicine machine in Changsha
Factory, YK-160）, softwood crosses 12 mesh sieves, particle is made；
Particle is sucked into fluidised bed granulator（Section of Chongqing City rising sun pharmaceutical machine equipment system, LGL-200.Dolly of infusing is that its is supporting
Equipment）, goods fluid boiling, 30min is dried under the conditions of 55 DEG C, control material moisture is 4.0%, and dry makes after terminating
Material is down to less than 30 DEG C, and the menthol prepared in step 6 and volatile oil mixed liquor are added into the small in-car of transfusion and penetrating
Intragranular, hydrojet 30~40Hz of frequency, after hydrojet terminates, discharging, the particle made is loaded in clean container；
Step 8：Whole grain, always mix
The particle that step 7 obtains is subjected to whole grain by swing pelletizing machine with 12 mesh sieves, particle after whole grain and by step 1
In parts by weight weigh magnesium stearate and add two-dimensional mixing machine, mix 20 minutes, load after well mixed in double-deck cleaning bag,
Sack is tightened, weighs, sticks middle product label, is examined.Always mixed material balance limit is 100%；
Step 8：Tabletting
Medicine tabletting after step 7 is always mixed with tablet press machine, tabletting, weight differential ± 4.5%, 0.2865- are carried out by 0.3g/ pieces
0.3135g, sheeting process material balance limit are 100%；
Step 9：Coating
Plain piece after the compacting of step 8 is coated, packed after the assay was approved.
In three above embodiment, embodiment 3 is most preferred embodiment.
Claims (3)
1. a kind of Chinese medicine for treating rhinitis tablet, it is characterised in that：It is made up of the raw material of following parts by weight：Stir-baked FRUCCTUS XANTHII 220-
235 parts, flower bud of lily magnolia 160-168 parts, asarum 31-34 parts, root of Dahurain angelica 31-34 parts, radix scutellariae 31-34 parts, bulbus fritillariae cirrhosae 43-45 parts, Fermented Soybean
43-45 parts, menthol 3-4 parts, light magnesium oxide 14-16 parts, sucrose 125-140 parts, magnesium stearate 2-3 parts, talcum powder 95-
105 parts, gelatin 0.7-0.8 parts, light green 0.017-0.022 parts, insect wax 0.21-0.23 parts.
2. a kind of Chinese medicine for treating rhinitis tablet according to claim 1, it is characterised in that：By the original of following parts by weight
Material composition：223.2 parts of stir-baked FRUCCTUS XANTHII, 165.6 parts of the flower bud of lily magnolia, 33.1 parts of asarum, 33.1 parts of the root of Dahurain angelica, 33.1 parts of radix scutellariae, bulbus fritillariae cirrhosae
44.6 parts, 44.6 parts of Fermented Soybean, 3.53 parts of menthol, 14.4 parts of light magnesium oxide, 130 parts of sucrose, 2 parts of magnesium stearate, talcum
100 parts of powder, 0.8 part of gelatin, light green 0.02 part, 0.22 part of insect wax.
A kind of 3. manufacture craft of a kind of Chinese medicine for treating rhinitis tablet according to claim 1, it is characterised in that：Including
Following steps：
Step 1：Feedstock treating
The flower bud of lily magnolia, asarum, the root of Dahurain angelica, radix scutellariae, bulbus fritillariae cirrhosae, Fermented Soybean are cleaned, by the flower bud of lily magnolia after cleaning, Fermented Soybean, bulbus fritillariae cirrhosae,
Weigh, enter net material storehouse；After the drinking water of asarum, the root of Dahurain angelica, radix scutellariae flowing is cleaned, segment in reciprocating medicine cutter is put into；Will
The radix scutellariae of cutting is placed in digester, is steamed 30 minutes；
By the asarum after cutting, the root of Dahurain angelica, the radix scutellariae loading a heatable brick bed car after moistening is steamed, it is 3~5cm to spread thickness, puts heated-air circulation oven
Middle drying, asarum are dried 4~6 hours in 40 ± 5 DEG C, and the root of Dahurain angelica is dried 3~5 hours in 55 ± 5 DEG C, and radix scutellariae dries 4 in 55 ± 5 DEG C
~6 hours, dried asarum, the root of Dahurain angelica, radix scutellariae moisture were no more than 12%, and outlet packs respectively after letting cool to room temperature, claimed
Weight, enter net material storehouse；
Sterilizing：The root of Dahurain angelica, bulbus fritillariae cirrhosae, the net medicinal material of Fermented Soybean are uniformly laid down into sterilization basket, sterilization basket is then put into damp and hot kill
In bacterium pot, between 0.1-0.3Mpa, 115 DEG C of temperature sterilizes 45 minutes control steam pressure；
Step 2：Pulverizing medicinal materials
Dry：By the root of Dahurain angelica, bulbus fritillariae cirrhosae, Fermented Soybean after radix scutellariae and sterilizing, put in heated-air circulation oven and dry, it is 80 to set temperature
DEG C, dry 8~12 hours；It is 80 DEG C that stir-baked FRUCCTUS XANTHII, which sets temperature, is dried 3~5 hours；Control moisture≤5%；
Stir-baked FRUCCTUS XANTHII is placed in pulverizer, crosses 20 mesh sieves, coarse powder is ground into, after crushing terminates, coarse powder is deposited in into clean appearance
In device, weigh, stir-baked FRUCCTUS XANTHII coarse powder yield >=98%, stick middle product label, be transferred to intermediate station；
Bulbus fritillariae cirrhosae, radix scutellariae, the root of Dahurain angelica, Fermented Soybean are weighed by the parts by weight in claim 1 be placed in pulverizer carry out mixed powder
It is broken, 80 mesh sieves are crossed, former powder is ground into, after crushing terminates, former powder is fitted into clean container, weigh, examine, former powder yield >=
97%；
Above-mentioned former powder is added in two-dimensional mixing machine, mixed 20 minutes, it is to be mixed uniformly after, be fitted into double-deck cleaning bag, tighten
Sack, weigh；
Step 3：Extraction
Weigh in the stir-baked FRUCCTUS XANTHII coarse powder input extractor of step 2, added equivalent to stir-fry by the parts by weight in claim 1
70% ethanol of 6 times of weight of achene of Siberian cocklebur coarse powder, soak 1 hour, be heated to reflux 5 hours, filter, reclaim ethanol, decoction is standby；To
Filter residue adds the drinking water equivalent to 6 times of weight of achene of Siberian cocklebur coarse powder, decocts 2.5 hours, merges decoction twice and, into storage tank, obtains grey
Ears or side handles of a utensil extract solution, mark are standby；
In the flower bud of lily magnolia input extractor weighed by the parts by weight in claim 1, the drink equivalent to 10 times of weight of the flower bud of lily magnolia is added
With water, soak 2 hours, steam distillation 4~6 hours, collect magnolia flower volatile oil, put in clean container, weigh, stick middle product
Label, kept at 2~10 DEG C, it is standby；
Weigh in dried asarum input extractor, added equivalent to 10 times of weights of asarum by the parts by weight in claim 1
The drinking water of amount, soak 2 hours, steam distillation 4~6 hours, collect Herba Asari volatile oil, put in clean container, weigh, stick
Middle product label, is stored at 2~10 DEG C, standby；
Step 4：Concentration
By the extract solution in step 3 by pipeline input dual-effect concentrator in concentrated, steam pressure be 0.01~
0.09MPa, it be 0.05~0.07MPa to control I effect vacuum, 70~80 DEG C of temperature, control II imitate vacuum for 0.06~
0.08MPa, 60~70 DEG C of temperature, is condensed into medicinal extract, is sent to by pipeline and receives cream tank, and adjustment medicinal extract is relatively close at 70 DEG C
Spend for 1.20~1.25, receive cream, medicinal extract is fitted into clean stainless steel cask, weighed, be capped, let cool to room temperature, stick middle product
Label, enter refrigeration house storage, standby, medicinal extract yield >=10%；
Step 5：It is prepared by simple syrup
Sucrose is weighed by the parts by weight in claim 1, sucrose is added in boiled water and dissolved, continues to heat and is stirred continuously
The simple syrup that 60-65% is made in nodeless mesh is all dissolved to sucrose, it is standby；
Step 6：The preparation of menthol and volatile oil mixed liquor
Dissolved by the menthol that the parts by weight in claim 1 weigh with 95% ethanol, 95% ethanol by weight proportion：Menthol
=2.5:3.53, menthol solution is made, then the Herba Asari volatile oil with being extracted in step 3 and magnolia flower volatile oil are well mixed, it is standby
With；
Step 7：Granulation, dry
Former powder that step 2 obtains is taken, light magnesium oxide is weighed by the parts by weight in claim 1 and adds trough type mixing machine, is done
After mixing 3~5 minutes, the obtained medicinal extract of step 4 is added and simple syrup that step 5 obtains, 2-4min is stirred, after being well mixed
Discharging, obtains softwood, softwood is inserted into oscillating granulator, softwood crosses 12 mesh sieves, particle is made；
Particle is sucked into fluidised bed granulator, goods fluid boiling, 20~30min is dried under the conditions of 45~60 DEG C, controls thing
Expect moisture be 3.0~5.0%, dry terminate after material is down to less than 30 DEG C, by the menthol prepared in step 6 with
Volatile oil mixed liquor adds the small in-car of transfusion and sprayed into particle, hydrojet 30~40Hz of frequency, after hydrojet terminates, discharging, will make
Good particle loads in clean container；
Step 8：Whole grain, always mix
The particle that step 7 obtains is subjected to whole grain by swing pelletizing machine with 12 mesh sieves, particle after whole grain and will by right
Ask the parts by weight in 1 to weigh magnesium stearate and add two-dimensional mixing machine, mix 20 minutes, load double-deck cleaning bag after well mixed
It is interior, sack is tightened, weighs, sticks middle product label, is examined；Always mixed material balance limit is 97~100%；
Step 8：Tabletting
Medicine tabletting after step 7 is always mixed with tablet press machine, tabletting is carried out by 0.3g/ pieces, sheeting process material balance limit is
97-100%；
Step 9：Coating
Plain piece after the compacting of step 8 is coated, packed after the assay was approved.
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| CN112717107A (en) * | 2020-12-30 | 2021-04-30 | 茂名市人民医院 | Chinese herbal medicine cold compress gel |
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