CN107441562A - A kind of medical thermo-sensitive material, heating muff and preparation method thereof - Google Patents
A kind of medical thermo-sensitive material, heating muff and preparation method thereof Download PDFInfo
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- CN107441562A CN107441562A CN201710684317.5A CN201710684317A CN107441562A CN 107441562 A CN107441562 A CN 107441562A CN 201710684317 A CN201710684317 A CN 201710684317A CN 107441562 A CN107441562 A CN 107441562A
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- 239000000463 material Substances 0.000 title claims abstract description 70
- 238000010438 heat treatment Methods 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 229920000049 Carbon (fiber) Polymers 0.000 claims abstract description 29
- 239000004917 carbon fiber Substances 0.000 claims abstract description 29
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims abstract description 29
- 229920001684 low density polyethylene Polymers 0.000 claims abstract description 21
- 239000004702 low-density polyethylene Substances 0.000 claims abstract description 21
- POOSGDOYLQNASK-UHFFFAOYSA-N tetracosane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCC POOSGDOYLQNASK-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 8
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 8
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims abstract description 6
- 229910021502 aluminium hydroxide Inorganic materials 0.000 claims abstract description 6
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 5
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 5
- 239000004014 plasticizer Substances 0.000 claims abstract description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 20
- 239000002002 slurry Substances 0.000 claims description 14
- 239000000126 substance Substances 0.000 claims description 10
- BGYHLZZASRKEJE-UHFFFAOYSA-N [3-[3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoyloxy]-2,2-bis[3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoyloxymethyl]propyl] 3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoate Chemical group CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(CCC(=O)OCC(COC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)(COC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)COC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)=C1 BGYHLZZASRKEJE-UHFFFAOYSA-N 0.000 claims description 6
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical group [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 5
- 238000000137 annealing Methods 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 230000004927 fusion Effects 0.000 claims description 5
- 238000002844 melting Methods 0.000 claims description 5
- 230000008018 melting Effects 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- -1 silicon Alkane Chemical class 0.000 claims description 4
- MQIUGAXCHLFZKX-UHFFFAOYSA-N Di-n-octyl phthalate Natural products CCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCC MQIUGAXCHLFZKX-UHFFFAOYSA-N 0.000 claims description 3
- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical group CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 claims description 3
- 238000010521 absorption reaction Methods 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 239000007822 coupling agent Substances 0.000 claims 1
- 229910052710 silicon Inorganic materials 0.000 claims 1
- 239000010703 silicon Substances 0.000 claims 1
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 abstract description 7
- 229910000077 silane Inorganic materials 0.000 abstract description 7
- 239000012567 medical material Substances 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000001802 infusion Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 206010027476 Metastases Diseases 0.000 description 2
- 230000003187 abdominal effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000012212 insulator Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
- 230000010412 perfusion Effects 0.000 description 2
- 239000004065 semiconductor Substances 0.000 description 2
- 239000002210 silicon-based material Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 206010048612 Hydrothorax Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000002612 cardiopulmonary effect Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005485 electric heating Methods 0.000 description 1
- 230000003028 elevating effect Effects 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000000505 pernicious effect Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000000015 thermotherapy Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/024—Carbon; Graphite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/3653—General characteristics of the apparatus related to heating or cooling by Joule effect, i.e. electric resistance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
The invention discloses a kind of medical thermo-sensitive material, heating muff and preparation method thereof, including following components is based on its important part：Medical grade low density polyethylene (LDPE) 18%~22%, lignocerane 54%~66%, medical grade carbon fiber 5%~10%, auxiliary material 10%~15%；Wherein, for auxiliary material according to mass percent meter, antioxidant, which accounts for the 10%~15% of the auxiliary material, crosslinking agent silane coupler and accounts for the 10%~15% of the auxiliary material, plasticizer and account for the 14%~20% of the auxiliary material, aluminium hydroxide, accounts for the 45%~51% of the auxiliary material；Moistening flatting agent accounts for the 8%~12% of the auxiliary material.Medical thermo-sensitive material provided by the present invention, there is good electric conductivity at 43 degrees Celsius, resistance increased dramatically during more than 43 degrees Celsius.
Description
Technical field
The invention belongs to field of medical materials, more particularly to a kind of medical thermo-sensitive material, heating muff and preparation method thereof.
Background technology
Can all there is the recurrence that substantial amounts of patient dies from chest, intraperitoneal malignant tumour every year, research has shown that, it is thin according to tumour
Born of the same parents organize to irrigate using heat with the different heat resistances of normal structure, can effectively kill remaining focus in splanchnocoel and dissociate thin
Born of the same parents and the focus of DISTANT METASTASES IN, the effect of operative treatment is improved, effectively treat pernicious chest, seroperitoneum and effectively control
The focus of DISTANT METASTASES IN processed.
The cure mechanism of heat perfusion as shown in Figure 1 is the tumor thermotherapy original that cancer cell can be effectively killed according to high temperature
Reason, using the external heating device of perfusion unit in use for thermochemical therapeutics by the hot body cavity for heating, patient being imported with cardiopulmonary bypass pump for the treatment of, and
43 DEG C or so of effective temperature is kept in regular hour, to give full play to hot killing mechanism, is shifted to being planted in extensively on serous coat
Cancer cell kills, and removes the focus for triggering malignant hydrothorax, reaches the purpose of effectively treatment cancerous effusion, in art and postoperative utilization
The treatment liquid of heating carries out hot cleaning, can prevent diffusivity diffusion transfer.
, it is necessary to place thicker conduit in patient abdomen in constant temperature abdominal thermal infusion therapeutic process, patient is introduced a drug into
Abdominal cavity, the operating temperature of conduit is 43 or so degrees Celsius, therefore substantial amounts of researcher is intended to want that finding one kind will lead
Pipe maintains 43 or so degrees Celsius of method.
The content of the invention
It is an object of the invention to provide a kind of medical thermo-sensitive material, thermo-sensitive material has well when less than 43-47 degrees Celsius
Electric conductivity, resistance increased dramatically during more than 43-47 degrees Celsius.
Rather it is necessary to provide the heating muff made of above-mentioned medical thermo-sensitive material.
Further, it is necessary to which the preparation method of above-mentioned heating muff is provided.
A kind of medical thermo-sensitive material, including following components is based on its important part：
Medical grade low density polyethylene (LDPE) 18%~22%, lignocerane 54%~66%, medical grade carbon fiber 5%~
10%, auxiliary material 10%~15%；
Wherein, for auxiliary material according to mass percent meter, antioxidant accounts for the 10%~15% of the auxiliary material, crosslinking
Agent silane coupler accounts for the 10%~15% of the auxiliary material, plasticizer and accounts for the 14%~20% of the auxiliary material, hydrogen-oxygen
Change aluminium and account for the 45%~51% of the auxiliary material；Moistening flatting agent accounts for the 8%~12% of the auxiliary material.
Wherein, the antioxidant is antioxidant 1010.
Wherein, the plasticizer is dioctyl phthalate.
A kind of heating muff made of medical thermo-sensitive material as described above, the heating muff are soft flaky materials, institute
State in flaky material and be provided with electrode.
A kind of preparation method for preparing medical material as described above, comprises the following steps：
The pretreatment of step (1) medical grade carbon fiber：Medical grade carbon fiber is cleaned with acetone soak, it is fine to remove medical grade carbon
Dimension table face can adsorbable organic substance, after filtering be evaporated under reduced pressure remove acetone, then at 100~150 DEG C heating 50~
150 minutes volatile substances for removing the absorption of medical grade carbon fiber surface；
Step (2) melting：According to raw material proportioning, at a temperature of 85~120 DEG C, low density polyethylene (LDPE) particle fusion is taken advantage of
Heat is added in lignocerane, the pretreated medical grade carbon fiber of step (1) and auxiliary material, and strong stirring mixes, and obtains pulpous state
Thing；
Step (3) is molded：The slurry that step (2) mixes is poured into mould, and copper core is placed in the both sides of slurry
Line, electroded soft flaky material is made；
Step (4) is heat-treated：The soft flaky material made is placed in electrically heated drying cabinet, started to warm up from room temperature, until
To specified 40~60 DEG C of annealing temperature, kept for 100~150 minutes, then by being cooled to room temperature with case.
Relatively above-mentioned background technology, medical thermo-sensitive material provided by the present invention, its switch temperature are Celsius in 43-47.5
In degree.Heating muff is enclosed on outside the input pipe of thermal infusion therapeutic equipment, with the auxiliary materials such as line by heating muff and conduit it
Between relative position fix, will electrode access circuit in begin to warm up so that conduit can be stably held in 43 degrees centigrades,
Such equipment is more beneficial for ensureing the effective temperature of medicine, is more suitable for constant temperature abdominal thermal infusion therapeutic process.
Brief description of the drawings
1st, Fig. 1 is thermo-chemotherapy mechanism schematic diagram；
2nd, Fig. 2 is the resistance-temperature curve of the sample of embodiment 1；
3rd, Fig. 3 is the resistance-temperature curve of the sample of embodiment 2；
4th, Fig. 4 is the resistance-temperature curve of the sample of embodiment 3.
Embodiment
In order that those skilled in the art more fully understand the present invention program, with reference to embodiment to this hair
It is bright to be described in further detail.
Material source：
Medical grade low density polyethylene (LDPE) (LDPE)：Li Ande Basels 3020D medical grades LDP
Crosslinking agent silane coupler：From road silicon material technology (Shanghai) Co., Ltd., model DW-56
Medical grade carbon fiber：Shandong Le Jin Medical Devices Co., Ltd.s, brand：Nine thats, model：JE-YJ.
Moistening flatting agent：From road silicon material technology (Shanghai) Co., Ltd., model DW-345
Resistance-temperature curve method of testing
Specifically method is --- it is 5 DEG C/min that sample is placed on into heating rate, and temperature elevating range is 20~65 DEG C of electric heating
In the desk-top air dry oven of constant temperature, and with digital thermometer and digimer respectively to sample when reality temperature and resistance enter
Row test, and resistance is converted into specific insulation, obtain resistivity-temperature curve.
Embodiment 1
Prepare medical material：
Stock：Formula as described in table 1 presses its weight (unit/kg) by material preparation；
Step (1)：The pretreatment of medical grade carbon fiber：Medical grade carbon fiber is cleaned with acetone soak, removes medical grade carbon
Fiber surface can adsorbable organic substance, after filtering be evaporated under reduced pressure remove acetone, then heat 50 minutes and remove at 150 DEG C
The volatile substances for going medical grade carbon fiber surface to adsorb；
Step (2) melting：At a temperature of 120 DEG C, by low density polyethylene (LDPE) particle fusion, lignocerane, step are added while hot
Suddenly (1) pretreated medical grade carbon fiber and auxiliary material (antioxidant 1010, crosslinking agent silane coupler (DW-56), adjacent benzene
Diformazan dioctyl phthalate, aluminium hydroxide, moistening flatting agent DW-345) in, strong stirring mixes, and obtains slurry；
Step (3) is molded：The slurry that step (2) mixes is poured into mould, and copper core is placed in the both sides of slurry
Line, electroded soft flaky material is made；
Step (4) is heat-treated：The soft flaky material made is placed in electrically heated drying cabinet, started to warm up from room temperature, until
To specified 40~60 DEG C of annealing temperature, kept for 100~150 minutes, then by being cooled to room temperature with case.
Embodiment 2
Prepare medical material：
Stock：Formula as described in table 1 presses its weight (unit/kg) by material preparation；
Step (1)：The pretreatment of medical grade carbon fiber：Medical grade carbon fiber is cleaned with acetone soak, removes medical grade carbon
Fiber surface can adsorbable organic substance, after filtering be evaporated under reduced pressure remove acetone, then heat 150 minutes and remove at 100 DEG C
The volatile substances for going medical grade carbon fiber surface to adsorb；
Step (2) melting：At a temperature of 85 DEG C, by low density polyethylene (LDPE) particle fusion, lignocerane, step are added while hot
(1) pretreated medical grade carbon fiber and auxiliary material (antioxidant 1010, crosslinking agent silane coupler (DW-56), adjacent benzene two
Formic acid dioctyl ester, aluminium hydroxide, moistening flatting agent DW-345) in, strong stirring mixes, and obtains slurry；
Step (3) is molded：The slurry that step (2) mixes is poured into mould, and copper core is placed in the both sides of slurry
Line, electroded soft flaky material is made；
Step (4) is heat-treated：The soft flaky material made is placed in electrically heated drying cabinet, started to warm up from room temperature, until
To specified 40~60 DEG C of annealing temperature, kept for 100~150 minutes, then by being cooled to room temperature with case.
Embodiment 3
Prepare medical material：
Stock：Formula as described in table 1 presses its weight (unit/kg) by material preparation；
Step (1)：The pretreatment of medical grade carbon fiber：Medical grade carbon fiber is cleaned with acetone soak, removes medical grade carbon
Fiber surface can adsorbable organic substance, after filtering be evaporated under reduced pressure remove acetone, then heat 100 minutes and remove at 100 DEG C
The volatile substances for going medical grade carbon fiber surface to adsorb；
Step (2) melting：At a temperature of 100 DEG C, by low density polyethylene (LDPE) particle fusion, lignocerane, step are added while hot
Suddenly (1) pretreated medical grade carbon fiber and auxiliary material (antioxidant 1010, crosslinking agent silane coupler (DW-56), adjacent benzene
Diformazan dioctyl phthalate, aluminium hydroxide, moistening flatting agent DW-345) in, strong stirring mixes, and obtains slurry；
Step (3) is molded：The slurry that step (2) mixes is poured into mould, and copper core is placed in the both sides of slurry
Line, electroded soft flaky material is made；
Step (4) is heat-treated：The soft flaky material made is placed in electrically heated drying cabinet, started to warm up from room temperature, until
To specified 40~60 DEG C of annealing temperature, kept for 100~150 minutes, then by being cooled to room temperature with case.
Table 1
| Embodiment 1 | Embodiment 2 | Embodiment 3 | |
| Medical grade low density polyethylene (LDPE) | 18 | 22 | 20 |
| Lignocerane | 66 | 54 | 60 |
| Medical grade carbon fiber | 5 | 9 | 10 |
| Antioxidant 1010 | 1.1 | 2.25 | 1.1 |
| Crosslinking agent silane coupler (DW-56) | 1.43 | 2.25 | 1 |
| Dioctyl phthalate | 1.54 | 2.25 | 2 |
| Aluminium hydroxide | 5.61 | 6.75 | 5.1 |
| Moistening flatting agent (DW-345 | 1.32 | 1.5 | 0.8 |
The gained sample of embodiment 1 is carried out to the test of resistance-temperature curve, obtained resistance-temperature curve is as shown in Fig. 2 pass through test
The resistance-temperature curve of embodiment, when the temperature of material is increased to 43.3 degrees Celsius, the resistivity of material quickly raises within the several years,
Illustrate that now material has walked semiconductor and become insulator, material is non-conductive, and now heat production starts to stop, pushing away over time
Move, radiating is big, and material temperature slowly reduces, and after temperature is less than 43 degrees Celsius, the resistivity of material diminishes again, now insulator
Semiconductor is begun to change into, heat production continues, and after so repeating, material temperature reaches balance, final stable in 43 degrees centigrades.
Embodiment 2 and the gained sample of embodiment 3 are carried out to the test of resistance-temperature curve, the resistance-temperature curve respectively obtained such as Fig. 3
Shown in Fig. 4, embodiment 2 and embodiment 3 and there was no significant difference, the resistance of resulting materials respectively at 45.3 degrees Celsius and
Near 47.3, resistivity increased dramatically so that the heating-up temperature for heating pipe sleeve is finally stable in 43 degrees centigrades.
To sum up, embodiment 1,2 and the switch temperature of 3 resulting materials are in 43-47.5 degree, obtained by material of the present invention
Heating muff be suitable for heat thermal infusion therapeutic equipment input pipe.
The foregoing description of the disclosed embodiments, professional and technical personnel in the field are enable to realize or using the present invention.
A variety of modifications to these embodiments will be apparent for those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, it is of the invention
The embodiments shown herein is not intended to be limited to, and is to fit to and principles disclosed herein and features of novelty phase one
The most wide scope caused.
Claims (5)
1. a kind of medical thermo-sensitive material, it is characterised in that including following components based on its important part：
Medical grade low density polyethylene (LDPE) 18%~22%, lignocerane 54%~66%, medical grade carbon fiber 5%~10% are auxiliary
Help material 10%~15%；
Wherein, for auxiliary material according to mass percent meter, antioxidant accounts for the 10%~15% of the auxiliary material, crosslinking agent silicon
Alkane coupling agent accounts for the 10%~15% of the auxiliary material, plasticizer and accounts for the 14%~20% of the auxiliary material, aluminium hydroxide
Account for the 45%~51% of the auxiliary material；Moistening flatting agent accounts for the 8%~12% of the auxiliary material.
2. medical thermo-sensitive material as claimed in claim 1, it is characterised in that：
The antioxidant is antioxidant 1010.
3. medical thermo-sensitive material as claimed in claim 2, it is characterised in that：
The plasticizer is dioctyl phthalate.
4. any one of claim 1-3 heating muff made of the medical thermo-sensitive material of one kind, it is characterised in that described to add
Thermal sleeve is soft flaky material, and electrode is provided with the flaky material.
5. the preparation method of heating muff described in a kind of claim 4, it is characterised in that comprise the following steps：
The pretreatment of step (1) medical grade carbon fiber：Medical grade carbon fiber is cleaned with acetone soak, removes medical grade carbon fiber surface
Face can adsorbable organic substance, after filtering be evaporated under reduced pressure remove acetone, then heated 50~150 minutes at 100~150 DEG C
Remove the volatile substances of medical grade carbon fiber surface absorption；
Step (2) melting：According to raw material proportioning, at a temperature of 85~120 DEG C, low density polyethylene (LDPE) particle fusion adds while hot
Enter in lignocerane, the pretreated medical grade carbon fiber of step (1) and auxiliary material, strong stirring mixes, and obtains slurry；
Step (3) is molded：The slurry that step (2) mixes is poured into mould, and copper core, system are placed in the both sides of slurry
Into electroded soft flaky material；
Step (4) is heat-treated：The soft flaky material made is placed in electrically heated drying cabinet, started to warm up from room temperature, is referred to until arriving
Determine 40~60 DEG C of annealing temperature, kept for 100~150 minutes, then by being cooled to room temperature with case.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710684317.5A CN107441562B (en) | 2017-08-11 | 2017-08-11 | Medical thermosensitive material, heating sleeve and preparation method thereof |
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| CN111803209A (en) * | 2020-07-24 | 2020-10-23 | 珠海富伊特科技有限公司 | Disposable laser metal thermotherapy target head |
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