CN107441244A - A kind of nano traditional Chinese medicine colloid decoction for treating hypoferric anemia and preparation method thereof - Google Patents
A kind of nano traditional Chinese medicine colloid decoction for treating hypoferric anemia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of nano traditional Chinese medicine colloid decoction for treating hypoferric anemia and preparation method thereof, it is made up of following components and its parts by weight:Radix Codonopsis 13 15, magnetite 30 32, the Radix Astragali 30 32, donkey-hide gelatin 12 13, deer horn glue 10 12, tortoiseshell 10 12, the bighead atractylodes rhizome 10 12, dried orange peel 10 12, Radix Angelicae Sinensis 15 17, the root of herbaceous peony 15 17, cultivated land 15 17, the tuber of multiflower knotweed 15 17, the fruit of Chinese wolfberry 15 17, dried human placenta 15 17, setose thistle 20 23, rice vinegar 100 120, fish bone collagen albumen 80 90, edible gelatin 20 23, red jujube polysaccharide 10 12, barrenwort 15 17.It is mutually coordinated between the complete each taste in side, make qi and blood smooth, spleen benefiting and stimulating the appetite, the patient for being chronically at morbid state has the function that temperature compensation conditioning, has special efficacy for treatment hypoferric anemia.
Description
Technical field
The present invention relates to traditional Chinese herbal decoction technical field, more particularly to a kind of nano traditional Chinese medicine colloid soup for treating hypoferric anemia
Agent and preparation method thereof.
Background technology
It is stronger that majority extracts isolated active ingredient activity from Chinese medicine, have in corresponding disease is treated compared with
The effect of good, as oleanolic acid has good bioactivity to liver;SN38 (SN-38) has very
Strong active anticancer;Ginkgolides has the effect of notable to cardiovascular and cerebrovascular disease;Legalon is to acute, chronic hepatitis, hepatic sclerosis
There is the effect of preferable with toxic liver injury;Taxol has the effect of prominent etc. for breast cancer, non-small cell lung cancer.But
These effective component of chinese medicine often have that solubility is small, and the problems such as bioavilability is low, it is new that this limits its to a certain extent
The exploitation and its clinical practice of medicine.Therefore, suitable method is found out to improve the solubility of Chinese medicine hardly soluble active ingredient, is improved
Its bioavilability is one of significant challenge that current Chinese medicine preparation worker faces.In recent years, nano suspension is as a kind of
The novel Drug Delivery Systems of insoluble drug, constantly attract people's attention.Nano suspension (nanosuspensions) system uses
A small amount of surfactant is stablized a kind of sub-micrometer colloidal dispersion research that pure drug particle is formed and shown, the dissolving of medicine
Different degrees of change can occur with change of size for degree, and when particle diameter is reduced to Nano grade, the solubility behavior of medicine can occur
Significantly improve.And medicine is exactly to exist with nm regime in nano suspension, high degree of dispersion, beneficial to the dissolution and absorption of medicine,
The bioavilability of medicine can be significantly improved.Therefore, nanometer suspension technology be presently believed to be solve insoluble drug dissolving and
The best method of absorption problem.Whether it is insoluble in the medicine of water or is not only insoluble in water but also is insoluble in the medicine of oil, can
By crushing or controlling crystallization technology that corresponding nano suspension is prepared.With traditional matrix scaffold type nanometer
System is different, and nano suspension without carrier material, divide medicine by the toxic side effect and cyclodextrin that effectively prevent cosolvent
Requirement of sub- size etc..Due to characteristic possessed by nano suspension, it has all embodied uniqueness in various methods of administration
Advantage, hank this as prescription is simple, prepares hoof that is quick, advantageously reducing reactive compound, improve drug dissolution and biology
Excitant and toxic side effect and relatively low administered volume etc. caused by availability, supplementary element of forgoing.Wherein high pressure homogenization method
It is to utilize cavitation and cavitation effect caused by high pressure homogenizer, the drug particles of micronizing is further crushed as nano-scale
Particle, while reduce the polydispersity of diameter of aspirin particle.The method is applied widely and preparation process is simple, without using organic examination
Agent, suitable for being both insoluble in water or being insoluble in the medicine of oil, and the reappearance of technique is preferable, is easy to large-scale industry metaplasia
Production, so as to be considered as the optimal preparation method of nano suspension.For the nano suspension stablized, nanoparticle is avoided
Son condenses, and needs to add some surfactants in preparation process.Surfactant is made using SDS, PVPK30 combination,
Obtained nano suspension particle diameter is small, and the system energy long period keeps stable.
Guo Jingjing exists《The research of Chinese medicine hardly soluble active ingredient delivery system based on nanometer suspension technology》It is middle by nanometer
Suspension technology is applied to grinding for Chinese medicine hardly soluble active ingredient delivery system and made internal disorder or usurp, intend choosing the slightly solubility of medicine Semen Herpetospermi effectively into
It is divided into model drug, using advanced nanometer suspension technology, nano suspension is prepared by the choosing of technique hoof, formulation optimization etc., and it is right
It carries out external physicochemical property and internal Pharmacokinetic Evaluation, is made internal disorder or usurp for other grinding for Chinese medicine hardly soluble active ingredient delivery system
Foundation is provided, to improve the dissolution in vitro of Chinese medicine hardly soluble active ingredient and vivo biodistribution availability.
Chinese medicine is processed using nanometer technology, drug particles is reached the level of superfines, specific surface area and adhesion show
Increase is write, solubility of the medicine in intestines and stomach substantially increases, and extends with intestinal wall time of contact, so as to increase the biology profit of medicine
Expenditure.He Jun etc. compares research using rat to the silymarin solid lipid nanoparticles oral absorption of different-grain diameter,
It was found that the bioavilability of 150 nm solid lipid nano granules apparently higher than particle diameter be two kinds of preparations of 500 nm and 1 000 nm, grain
Footpath size has a significant impact to the oral absorption of silymarin.Chinese medicine is processed using nanometer technology, can break the cell membrane of plant
It is broken, it is easy to oozing out for active ingredient.Ganoderma lucidum embrace son have it is tough and tensile it is double-deck embrace wall, general crushing technology difficulty is by its broken wall, it is impossible to carries
Lipid active material therein is taken, thus its effect is had a greatly reduced quality.Traditional Chinese medicine formulation is with respect to aging, single.It is existing in recent years
Occur in succession for Chinese medicine such as dripping pill, injection, cutaneous permeable agent etc., but compared with chemical drugs etc., modern Chinese herbal medicine formulation quantity is still
It is relatively fewer, kind is more single.Nano traditional Chinese medicine particle diameter is small, Selective adsorption is strong, there is stronger penetration power.Utilize nanometer technology
It is undoubtedly abundant form of Chinese drug with nano material, promotes the effective way of modernization of Chinese medicine development.
The content of the invention
A kind of the defects of the object of the invention is exactly to make up prior art, there is provided nano traditional Chinese medicine for treating hypoferric anemia
Colloid decoction.
The present invention is achieved by the following technical solutions:
A kind of nano traditional Chinese medicine colloid decoction for treating hypoferric anemia, it is made up of following components and its parts by weight:
Radix Codonopsis 13-15, magnetite 30-32, Radix Astragali 30-32, donkey-hide gelatin 12-13, deer horn glue 10-12, tortoiseshell 10-12, bighead atractylodes rhizome 10-12,
It is dried orange peel 10-12, Radix Angelicae Sinensis 15-17, root of herbaceous peony 15-17, cultivated land 15-17, tuber of multiflower knotweed 15-17, fruit of Chinese wolfberry 15-17, dried human placenta 15-17, big
Ji 20-23, rice vinegar 100-120, fish bone collagen albumen 80-90, edible gelatin 20-23, red jujube polysaccharide 10-12, barrenwort 15-
17。
A kind of described nano traditional Chinese medicine colloid decoction for treating hypoferric anemia, is made of the following steps:
1), respectively Radix Codonopsis, the Radix Astragali, tortoiseshell, the bighead atractylodes rhizome, Radix Angelicae Sinensis, the root of herbaceous peony, cultivated land, the tuber of multiflower knotweed, dried human placenta, setose thistle, barrenwort are cleaned it is dry
After net, preliminary cutting makes uniform in size, natural-wind dry, then adds pulverizer and is crushed, crosses 60-80 mesh sieves;
2), will add rice vinegar after magnetite, dried orange peel, fruit of Chinese wolfberry rinse and soaked, then measure distilled water with 10-12 times and mix addition
Mixer uniform stirring, filter-cloth filtering slagging-off, filtrate is added to 13-15% bamboo charcoal, stands 2-2.5 hours;
3), by SDS and PVPK30 with 2:3-4 ratio mixing, 1000-1500 times of addition are measured distilled water and fully dissolved, and take quality
Fraction is that the 1-1.2% solution mixes with step 1 gained medicinal powder, and adds step 2 gained filtrate, in 7000-8000r/min height
Fast Probe Ultrasonic Searching 6-8 times, the even 8-10 circles of high pressure breast under the conditions of pressure is 1000-1200bar;
4), step 3 gains and fish bone collagen albumen, edible gelatin, donkey-hide gelatin, deer horn glue are sufficiently mixed, heat while stirring
To 85-90 DEG C, 50-60 DEG C is cooled to after homogeneous, is distributed into bag, it is stored refrigerated.
It is an advantage of the invention that:
1st, a kind of nano traditional Chinese medicine colloid decoction for treating hypoferric anemia of the invention, high pressure homogenization method is to utilize high pressure homogenizer
Caused by cavitation and cavitation effect, the drug particles of micronizing are further crushed to the particle for nano-scale, while reduce medicine
The polydispersity of thing particle diameter;Pure drug particle is stablized using a small amount of SDS and PVPK30 mixed surfactants, makes nano suspension
Middle medicine exists with nm regime, high degree of dispersion;The characteristics of nano traditional Chinese medicine is due to its particle diameter and form, easily by the withered no of liver
Cell capture and phagocytosis, make medicine in aggregation in liver, then progressively degrade, be discharged into blood, strengthen drug effect.
2nd, a kind of nano traditional Chinese medicine colloid decoction for treating hypoferric anemia of the invention, Chinese medicine is processed using nanometer technology,
Drug particles are made to reach the level of superfines, specific surface area and adhesion significantly increase, solubility of the medicine in intestines and stomach
Obvious increase, extends with intestinal wall time of contact, so as to increase the bioavilability of medicine.
3rd, a kind of nano traditional Chinese medicine colloid decoction for treating hypoferric anemia of the invention, homogeneous, efficacy stability, mouthfeel
Exquisiteness, the gentle gloss of colloid, contained Radix Astragali nature and flavor are sweet, and tepor enters lung, the spleen channel, has tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema
And other effects, it is equipped with Radix Codonopsis, Radix Angelicae Sinensis enhancing inrigorating qi and promoting blood circulation effect;Tortoiseshell nature and flavor are sweet, salty, cold, enter the heart, liver and kidney channel, nourishing and suppressing Yang,
The strong bone of kidney-nourishing, blood-nourishing bushing, reducing the asthenic fever, it is equipped with magnetite enhancing sedation;Dried orange peel is bitter in taste, pungent, warm, enters spleen, Liver Channel, qi-regulating
Invigorating the spleen, it is eliminating dampness and eliminating phlegm, Radix Codonopsis enhancing invigorating the spleen, tonifying Qi effect are equipped with, cultivated land is equipped with and enriches blood enriching yin;Barrenwort nature and flavor are pungent, warm, enter
Liver and kidney channel, filling liver kidney, strengthening the bones and muscles, supporing yang strengthening the essence, wind-damp dispelling, it is equipped with setose thistle and mitigates scorching property.Mutually assisted between the complete each taste in side
Adjust, make qi and blood smooth, spleen benefiting and stimulating the appetite, the patient for being chronically at morbid state has the function that temperature compensation conditioning, for treating iron deficiency
Property anaemia has special efficacy, drinks for a long time better.
Embodiment
A kind of nano traditional Chinese medicine colloid decoction for treating hypoferric anemia, it is made up of following components and its parts by weight:
Radix Codonopsis 13, magnetite 30, the Radix Astragali 30, donkey-hide gelatin 12, deer horn glue 10, tortoiseshell 10, the bighead atractylodes rhizome 10, dried orange peel 10, Radix Angelicae Sinensis 15, the root of herbaceous peony 15,
Cultivated land 15, the tuber of multiflower knotweed 15, the fruit of Chinese wolfberry 15, dried human placenta 15, setose thistle 20, rice vinegar 100, fish bone collagen albumen 80, edible gelatin 20, jujube
Polysaccharide 10, barrenwort 15.
A kind of described nano traditional Chinese medicine colloid decoction for treating hypoferric anemia, is made of the following steps:
1), respectively Radix Codonopsis, the Radix Astragali, tortoiseshell, the bighead atractylodes rhizome, Radix Angelicae Sinensis, the root of herbaceous peony, cultivated land, the tuber of multiflower knotweed, dried human placenta, setose thistle, barrenwort are cleaned it is dry
After net, preliminary cutting makes uniform in size, natural-wind dry, then adds pulverizer and is crushed, crosses 60 mesh sieves;
2), will after magnetite, dried orange peel, fruit of Chinese wolfberry rinse, add rice vinegar soaked, then with 10 times amount distilled water mix addition stir
Machine uniform stirring, filter-cloth filtering slagging-off, by the bamboo charcoal of filtrate addition 13%, stand 2 hours;
3), by SDS and PVPK30 with 2:3 ratio mixing, add 1000 times of amount distilled water and fully dissolve, it is 1% to take mass fraction
The solution mixes with step 1 gained medicinal powder, and adds step 2 gained filtrate, in 7000r/min high speeds Probe Ultrasonic Searching 6 times, is pressing
Even 8 circle of high pressure breast under the conditions of power is 1000bar;
4), step 3 gains and fish bone collagen albumen, edible gelatin, donkey-hide gelatin, deer horn glue are sufficiently mixed, heat while stirring
To 85 DEG C, 50 DEG C are cooled to after homogeneous, is distributed into bag, it is stored refrigerated.
Claims (2)
1. a kind of nano traditional Chinese medicine colloid decoction for treating hypoferric anemia, it is characterised in that it is by following components and its parts by weight
It is made:
Radix Codonopsis 13-15, magnetite 30-32, Radix Astragali 30-32, donkey-hide gelatin 12-13, deer horn glue 10-12, tortoiseshell 10-12, bighead atractylodes rhizome 10-12,
It is dried orange peel 10-12, Radix Angelicae Sinensis 15-17, root of herbaceous peony 15-17, cultivated land 15-17, tuber of multiflower knotweed 15-17, fruit of Chinese wolfberry 15-17, dried human placenta 15-17, big
Ji 20-23, rice vinegar 100-120, fish bone collagen albumen 80-90, edible gelatin 20-23, red jujube polysaccharide 10-12, barrenwort 15-
17。
A kind of 2. nano traditional Chinese medicine colloid decoction for treating hypoferric anemia according to claim 1, it is characterised in that be by
Made of the following steps:
1), respectively Radix Codonopsis, the Radix Astragali, tortoiseshell, the bighead atractylodes rhizome, Radix Angelicae Sinensis, the root of herbaceous peony, cultivated land, the tuber of multiflower knotweed, dried human placenta, setose thistle, barrenwort are cleaned it is dry
After net, preliminary cutting makes uniform in size, natural-wind dry, then adds pulverizer and is crushed, crosses 60-80 mesh sieves;
2), will add rice vinegar after magnetite, dried orange peel, fruit of Chinese wolfberry rinse and soaked, then measure distilled water with 10-12 times and mix addition
Mixer uniform stirring, filter-cloth filtering slagging-off, filtrate is added to 13-15% bamboo charcoal, stands 2-2.5 hours;
3), by SDS and PVPK30 with 2:3-4 ratio mixing, 1000-1500 times of addition are measured distilled water and fully dissolved, and take quality
Fraction is that the 1-1.2% solution mixes with step 1 gained medicinal powder, and adds step 2 gained filtrate, in 7000-8000r/min height
Fast Probe Ultrasonic Searching 6-8 times, the even 8-10 circles of high pressure breast under the conditions of pressure is 1000-1200bar;
4), step 3 gains and fish bone collagen albumen, edible gelatin, donkey-hide gelatin, deer horn glue are sufficiently mixed, heat while stirring
To 85-90 DEG C, 50-60 DEG C is cooled to after homogeneous, is distributed into bag, it is stored refrigerated.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108283652A (en) * | 2018-02-27 | 2018-07-17 | 贵安新区瑞诚生物工程有限公司 | A kind of preparation method and its production system of small molecule Chinese medicine and beverage |
CN109010371A (en) * | 2018-08-17 | 2018-12-18 | 药圣堂(湖南)制药有限公司 | A kind of donkey-hide gelatin oral preparation and preparation method thereof |
-
2017
- 2017-08-22 CN CN201710725571.5A patent/CN107441244A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108283652A (en) * | 2018-02-27 | 2018-07-17 | 贵安新区瑞诚生物工程有限公司 | A kind of preparation method and its production system of small molecule Chinese medicine and beverage |
CN109010371A (en) * | 2018-08-17 | 2018-12-18 | 药圣堂(湖南)制药有限公司 | A kind of donkey-hide gelatin oral preparation and preparation method thereof |
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