CN107441219B - Pharmaceutical composition for improving immune function of acquired immune deficiency syndrome and application thereof - Google Patents
Pharmaceutical composition for improving immune function of acquired immune deficiency syndrome and application thereof Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for improving immune function of AIDS and application thereof. The pharmaceutical composition for improving the immune function of AIDS comprises monkshood, asarum, semen brassicae, fingered citron, salvia miltiorrhiza and pepper, wherein the mass ratio of the monkshood, the asarum, the semen brassicae, the fingered citron, the salvia miltiorrhiza and the pepper is (0.5-1.5) to (0.4-0.6) to (0.5-1.5): (0.5 to 1.5), (0.5 to 1.5) and (0.5 to 1.5). The application of the medicinal composition for improving the immune function of the AIDS is the application of the medicinal composition in preparing the traditional Chinese medicine acupoint application for improving the immune function of the AIDS. The invention has simple and convenient operation and easy carrying, and can be used by patients; the composition is safe, effective and low in cost, can be applied with HAART western medicine for treating AIDS, does not increase oral dosage through gastrointestinal tract, and does not influence the virus inhibition effect of the western medicine.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition for improving immune function of AIDS and application thereof.
Background
AIDS, acquired immunodeficiency syndrome (AIDS), is a chronic lethal infectious disease caused by the Human Immunodeficiency Virus (HIV). The currently widely used method for treating HIV/AIDS is HAART therapy, which mainly treats AIDS by the combined use of three antiviral drugs, and the therapy has good clinical effects, but has some problems, such as: the CD4 with toxic and side effects and poor immune reconstitution is in a lower level for a long time, the drug resistance problem of lifelong administration and high treatment cost and the like become a great problem in clinical research and AIDS prevention and treatment. The traditional Chinese medicine has good effects of treating AIDS for more than ten years, especially improving HIV/AIDS clinical symptoms, lightening HAART adverse reaction, improving immunologic function, improving life quality and the like, and has unique advantages. However, the traditional Chinese medicine treatment is mostly limited to oral medicines at present, and the traditional Chinese medicine non-medicine therapy for treating AIDS reports that moxibustion can obviously improve the clinical symptoms of AIDS diarrhea at home, but the clinical research of other traditional Chinese medicine external treatment therapies (such as acupoint application) is lacked.
Disclosure of Invention
The first purpose of the invention is to provide a pharmaceutical composition for improving immune function of AIDS; the second purpose is to provide the application of the pharmaceutical composition for improving the immune function of AIDS.
The first purpose of the invention is realized in such a way that the pharmaceutical composition for improving the immune function of AIDS comprises monkshood, asarum, semen brassicae, fingered citron, salvia miltiorrhiza and pepper, wherein the mass ratio of the monkshood, the asarum, the semen brassicae, the fingered citron, the salvia miltiorrhiza and the pepper is (0.5-1.5): 0.4-0.6): 0.5-1.5: (0.5-1.5): 0.5-1.5).
The second purpose of the invention is realized by the application of the medicinal composition for improving the immune function of the AIDS in preparing the Chinese medicinal acupoint application for improving the immune function of the AIDS.
The traditional Chinese medicine external treatment method has the advantages of simplicity, convenience and low cost, and the application of acupoint application for treating AIDS is explored from 2014, so that a better clinical curative effect is achieved. The acupoint application is based on the holistic concept of traditional Chinese medicine, the theory of meridians and collaterals and the physiological function of acupoints, and achieves the purposes of improving the immunity and disease resistance of the organism by the direct action of medicine absorption at specific parts and the indirect action of stimulating the channels and qi by the acupoints.
Yunnan is the area of high incidence of AIDS, and Kunming's traditional Chinese medicine hospital has become one of earliest and largest-scale hospitals in Yunnan three hospitals for developing traditional Chinese medicine for preventing and treating AIDS, and is also a national free antiviral treatment point. The inventor is ChenXin, a main task of AIDS department in traditional Chinese medicine hospital in Kunming, develops related work such as AIDS traditional Chinese medicine treatment, antiviral treatment, Chinese and western medicine cooperative treatment and research for more than 11 years from 2005, collects and treats 1200 more people of HIV/AIDS patients so far, hosts 3 scientific research subjects of national level, provincial level and municipal level, issues more than ten professional papers, and accumulates abundant clinical and scientific research experiences. In addition to the treatment of oral traditional Chinese medicine based on syndrome differentiation, the method also actively explores and applies traditional Chinese medicine special therapy (acupoint application and moxibustion) to treat HIV/AIDS in 2014, and obtains 3 topic projects.
The invention has simple and convenient operation and easy carrying, and can be used by patients; safety, and no allergy or adverse skin reaction under correct operation through 3 years of scientific research and clinical tests; the medicine is effective, and 2 research projects prove that the medicine has obvious curative effects of improving the immunologic function, improving clinical symptoms and the like for AIDS patients; the price is low, and the manufacturing cost is far lower than that of HAART drugs from the aspect of sanitation and economy; can be applied together with HAART western medicine for treating AIDS, without increasing oral dosage via gastrointestinal tract, and without affecting virus inhibition effect of western medicine.
Detailed Description
The present invention is further illustrated by the following examples, which are not intended to be limiting in any way, and any modifications or alterations based on the teachings of the present invention are intended to fall within the scope of the present invention.
The pharmaceutical composition for improving the immune function of AIDS comprises monkshood, asarum, brassica alba boiss, fingered citron, salvia miltiorrhiza and pepper, wherein the mass ratio of the monkshood, the asarum, the brassica alba boiss, the fingered citron, the salvia miltiorrhiza and the pepper is (0.5-1.5): (0.4-0.6): (0.5-1.5): (0.5-1.5): 0.5-1.5).
The pharmaceutical composition for improving the immune function of AIDS also comprises ginger juice.
The pharmaceutical composition for improving the immune function of the AIDS also comprises borneol.
The pharmaceutical composition for improving the immune function of AIDS comprises, by mass, 0.5-1.5 parts of monkshood, 0.4-0.6 parts of manchurian wildginger, white mustard seed, finger citron, red sage root, pepper, ginger juice and borneol, 0.5-1.5 parts of monkshood, 0.5-1.5 parts of manchurian wildginger and 0.04-0.06 parts of borneol.
The pharmaceutical composition for improving the immune function of AIDS comprises monkshood, asarum, semen brassicae, fingered citron, salvia miltiorrhiza, pepper, ginger juice and borneol in a mass ratio of 1:0.5:1:1:1:1: 0.05.
The application of the medicinal composition for improving the immune function of the AIDS is the application of the medicinal composition for improving the immune function of the AIDS in preparing the Chinese medicinal acupoint application for improving the immune function of the AIDS.
The traditional Chinese medicine acupoint application agent for improving the immune function of the acquired immune deficiency syndrome is prepared by crushing monkshood, asarum, brassica alba boiss, fingered citron, salvia miltiorrhiza and pepper in a formula ratio, sieving the monkshood, asarum, brassica alba boiss, fingered citron, salvia miltiorrhiza and pepper with a 80-mesh sieve to obtain a material a, adding water into starch with the weight percentage of 8-12% of the material a to prepare a paste to obtain a material b, and uniformly mixing the material a and the material b to obtain a target traditional Chinese medicine acupoint application agent for improving.
The traditional Chinese medicine acupoint application agent for improving the immune function of the acquired immune deficiency syndrome is prepared by crushing monkshood, asarum, brassica alba boiss, fingered citron, salvia miltiorrhiza and pepper in a formula ratio, sieving the monkshood, asarum, brassica alba boiss, salvia miltiorrhiza and pepper with a 80-mesh sieve to obtain a material a, adding water into 8-12 wt% of the material a to prepare a paste to obtain a material b, uniformly mixing the material a and the material b, adding ginger juice in the formula ratio, and uniformly mixing to obtain a target traditional Chinese medicine acupoint application agent for improving the immune function of the acquired immune deficiency syndrome.
The preparation method of the traditional Chinese medicine acupoint application agent for improving the immune function of the acquired immune deficiency syndrome comprises the steps of crushing monkshood, asarum, white mustard seed, fingered citron, salvia miltiorrhiza and pepper in a formula ratio, sieving the monkshood, asarum, white mustard seed, fingered citron, salvia miltiorrhiza and pepper with a 80-mesh sieve to obtain a material a, adding 8-12% of weight percent of the material a into water to prepare a paste to obtain a material b, dissolving borneol in the formula ratio with ethanol with the weight and the volume being 3-5 times of that of the borneol to obtain a material c, uniformly mixing the material a and the material b, adding ginger juice in the formula ratio, uniformly mixing, and finally adding the material c, and uniformly mixing to obtain.
The invention is further illustrated by the following specific examples:
example 1
Weighing 100g of monkshood, 80g of asarum, 100g of white mustard seed, 100g of fingered citron, 100g of salvia miltiorrhiza and 100g of pepper, respectively crushing, sieving with a 80-mesh sieve, and uniformly mixing to obtain a material a; and additionally weighing 80g of starch, adding water to mix into paste to obtain a material b, and uniformly mixing the material a and the material b to obtain the traditional Chinese medicine acupoint application agent for improving the immune function of the acquired immune deficiency syndrome of the target object.
Example 2
Weighing 200g of monkshood, 100g of asarum, 200g of white mustard seed, 200g of fingered citron, 200g of salvia miltiorrhiza and 200g of pepper, respectively crushing, sieving with a 80-mesh sieve, and uniformly mixing to obtain a material a; and weighing 100g of starch, adding water, blending into paste to obtain a material b, and uniformly mixing the material a and the material b to obtain the traditional Chinese medicine acupoint application agent for improving the immune function of the acquired immune deficiency syndrome of the target object.
Example 3
Weighing 300g of monkshood, 120g of asarum, 300g of white mustard seed, 300g of fingered citron, 300g of salvia miltiorrhiza and 300g of pepper, respectively crushing, sieving with a 80-mesh sieve, and uniformly mixing to obtain a material a; and additionally, 120g of starch is weighed and added with water to be prepared into paste to obtain a material b, and the material a and the material b are uniformly mixed to obtain the traditional Chinese medicine acupoint application agent for improving the immune function of the acquired immune deficiency syndrome of the target object.
Example 4
Weighing 100g of monkshood, 80g of asarum, 100g of white mustard seed, 100g of fingered citron, 100g of salvia miltiorrhiza and 100g of pepper, respectively crushing, sieving with a 80-mesh sieve, and uniformly mixing to obtain a material a; and additionally weighing 80g of starch, adding water to prepare a paste to obtain a material b, uniformly mixing the material a and the material b, adding 100g of ginger juice, and uniformly mixing to obtain the traditional Chinese medicine acupoint application agent for improving the immune function of the acquired immune deficiency syndrome of the target object.
Example 5
Weighing 200g of monkshood, 100g of asarum, 200g of white mustard seed, 200g of fingered citron, 200g of salvia miltiorrhiza and 200g of pepper, respectively crushing, sieving with a 80-mesh sieve, and uniformly mixing to obtain a material a; and weighing 100g of starch, adding water to blend into paste to obtain a material b, uniformly mixing the material a and the material b, adding 100-200-300 g of ginger juice, and uniformly mixing to obtain the target Chinese medicinal acupoint application agent for improving the immune function of the AIDS.
Example 6
Weighing 300g of monkshood, 120g of asarum, 300g of white mustard seed, 300g of fingered citron, 300g of salvia miltiorrhiza and 300g of pepper, respectively crushing, sieving with a 80-mesh sieve, and uniformly mixing to obtain a material a; and additionally weighing 120g of starch, adding water to blend into paste to obtain a material b, uniformly mixing the material a and the material b, adding 100-200-300 g of ginger juice, and uniformly mixing to obtain the traditional Chinese medicine acupoint application agent for improving the immune function of the acquired immune deficiency syndrome of the target object.
Example 7
Weighing 100g of monkshood, 120g of asarum, 200g of white mustard seed, 300g of fingered citron, 300g of salvia miltiorrhiza and 100g of pepper, respectively crushing, sieving with a 80-mesh sieve, and uniformly mixing to obtain a material a; and weighing 100g of starch, adding water to prepare a paste to obtain a material b, weighing 10g of borneol, adding 40ml of ethanol solution with the volume percentage concentration of 90% to dissolve the mixture to obtain a material c, then uniformly mixing the material a and the material b, adding 300g of ginger juice, and finally adding the material c to uniformly mix to obtain the traditional Chinese medicine acupoint application agent for improving the immune function of the acquired immune deficiency syndrome of the target object.
Example 8
Weighing 300g of monkshood, 100g of asarum, 300g of white mustard seed, 100g of fingered citron, 200g of salvia miltiorrhiza and 200g of pepper, respectively crushing, sieving with a 80-mesh sieve, and uniformly mixing to obtain a material a; and additionally weighing 120g of starch, adding water to prepare a paste to obtain a material b, weighing 12g of borneol, adding 50ml of 80% ethanol solution with volume percentage concentration to dissolve the mixture to obtain a material c, then uniformly mixing the material a and the material b, adding 200g of ginger juice, and finally adding the material c to uniformly mix to obtain the traditional Chinese medicine acupoint application agent for improving the immune function of the acquired immune deficiency syndrome of the target object.
Example 9
Weighing 200g of monkshood, 200g of asarum, 200g of white mustard seed, 100g of fingered citron, 200g of salvia miltiorrhiza and 100g of pepper, respectively crushing, sieving with a 80-mesh sieve, and uniformly mixing to obtain a material a; and additionally weighing 80g of starch, adding water to prepare a paste to obtain a material b, weighing 8g of borneol, adding 30ml of 70% ethanol solution with volume percentage concentration to dissolve the borneol to obtain a material c, then uniformly mixing the material a and the material b, adding 100g of ginger juice, and finally adding the material c to uniformly mix to obtain the traditional Chinese medicine acupoint application agent for improving the immune function of the acquired immune deficiency syndrome of the target object.
Example 10
The following tests were conducted using the traditional Chinese medicine acupoint application for enhancing AIDS immunity prepared in example 2:
the test method is as follows:
adopts a random comparison test formulaMethod, positive for HIV confirmation, with a CD4 count of less than 350/mm370 patients aged 18-65 were randomly divided into a test group (HAART combined with the traditional Chinese medicine acupoint application for improving AIDS immunity prepared in example 2) and a control group (HAART alone). Eliminating patients with active tuberculosis, tumor, nervous system injury, and immune function affected by recent taking immunoregulation medicine; suffering from opportunistic infections, severe psychiatric and neurological disorders and pregnant and lactating women.
The treatment method comprises the following steps:
the test group had HAART + the traditional Chinese medicine acupoint application agent for improving the immune function of aids prepared in example 2, the HAART protocol was the same as that of the control group, and the traditional Chinese medicine acupoint application agent for improving the immune function of aids prepared in example 2 was applied to 5 acupoints, 10 h/time and 1 time/week, such as the lumbar region, the diaphragmatic acupoints and the triple-jiao acupoints. The control group is only HAART, and adopts a national free first-line scheme, and the medicine composition comprises lamivudine, zidovudine, tenofovir, nevirapine and efavirenz.
Peripheral venous blood was collected at 0, 6 and 12 months after treatment of 2 patients, and the absolute count of CD4 cells was measured within 7 hours using a flow cytometer manufactured by BD corporation, usa.
The curative effect is as follows:
36 cases (13 cases for HAART treatment, 23 cases for HAART ≥ 2 years) in the test group, and 34 cases of HAART alone (9 cases for HAART treatment, 25 cases for HAART ≥ 2 years) in the control group. Statistical data after eliminating 12 cases of exfoliation and experimental data insufficiency, the demographic characteristics of the first two groups of 70 cases before treatment were compared, and the difference was not statistically significant (P> 0.05) as detailed in table 1.
TABLE 1 two groups of patients demographic characteristics comparison (n, +/-s)
Before the group is entered, the difference between the CD4 cell count of the test group and the control group has no statistical significance: (t=3.709,P> 0.05). The CD4 cell count of the two groups is increased compared with that of the two groups at months 6 and 12, wherein the CD4 cell level of the test group at months 6 and 12 is obviously higher than that of the test group at months 6The difference is statistically significant at the same time level in the control group: (F=10.061，P< 0.05). See table 2 for details.
TABLE 2 two treatment groups comparison of CD4 cell levels (+ -s) (counts/. mu.L) at 0, 6, 12 months of treatment
Note: a:P＞0.05
the results of comparison of the CD4 cell counts in the two groups for HAART treatment and HAART period of 2 years or more are shown in Table 3.
TABLE 3 initial HAART treatment, ≧ 2 years two sets of CD4 cell level comparison (± s) (individual/. mu.L)
Note: treating for the first time a:t=1.35,P= 0.194; a is more than or equal to 2 years:t=1.323,P=0.192
the average of CD4 cell count water of 6 th and 12 th months after the treatment of HAART combined with the traditional Chinese medicine acupoint application agent for improving the immune function of AIDS prepared in the embodiment 2 is larger than that of the HAART group. The cell counts of the peripheral blood CD4 of the traditional Chinese medicine acupoint application treatment group for improving the immune function of AIDS and the simple HAART group prepared in the combined embodiment 2 are improved after treatment, but the cell counts of the CD4 of the traditional Chinese medicine acupoint application treatment group for improving the immune function of AIDS, which is prepared in the combined embodiment 2, are obviously higher than the synchronous level of the simple HAART group at 6 th and 12 th months, which shows that the curative effect of the traditional Chinese medicine acupoint application agent for improving the immune function of AIDS and the HAART combined with the traditional Chinese medicine acupoint application agent for improving the immune function of AIDS, which is prepared in the embodiment 2, is better than that of the simple HAART in the aspect of improving the cell level of the peripheral blood CD 4. The change of HIV viral load monitored in the same period is not different from that of a simple HAART group, which shows that the traditional Chinese medicine acupoint application agent for improving the immune function of AIDS, prepared in the example 2, does not influence the inhibiting effect of HAART medicines on HIV.
Example 11
Tests carried out by using the traditional Chinese medicine acupoint application agents for improving the immune function of AIDS prepared in example 2 prepared in example 1, example 3, example 4, example 5, example 6, example 7, example 8 and example 9 respectively show that the traditional Chinese medicine acupoint application agent for improving the immune function of AIDS of the invention is combined with HAART, and the curative effect of the HAART on improving the level of CD4 cells in peripheral blood is better than that of the HAART alone.
Claims (8)
1. A pharmaceutical composition for improving immune function of AIDS patients is characterized by being prepared from monkshood, asarum, semen brassicae, fingered citron, salvia miltiorrhiza and pepper, wherein the monkshood, the asarum, the semen brassicae, the fingered citron, the salvia miltiorrhiza and the pepper are mixed according to the mass ratio of (0.5-1.5) to (0.4-0.6) to (0.5-1.5).
2. A pharmaceutical composition for improving immune function of AIDS patients is characterized by being prepared from monkshood, asarum, semen brassicae, fingered citron, salvia miltiorrhiza, pepper and ginger juice, wherein the monkshood, the asarum, the semen brassicae, the fingered citron, the salvia miltiorrhiza and the pepper are mixed according to the mass ratio of (0.5-1.5), (0.4-0.6), (0.5-1.5) and (0.5-1.5).
3. A pharmaceutical composition for improving immune function of AIDS patients is characterized by being prepared from monkshood, asarum, semen brassicae, fingered citron, salvia miltiorrhiza, pepper, ginger juice and borneol, wherein the monkshood, the asarum, the semen brassicae, the fingered citron, the salvia miltiorrhiza and the pepper are mixed according to the mass ratio of (0.5-1.5) to (0.4-0.6) to (0.5-1.5).
4. The pharmaceutical composition according to claim 3, wherein the pharmaceutical composition is prepared from aconite, asarum, brassica alba boiss, fingered citron, salvia miltiorrhiza, pepper, ginger juice and borneol according to the mass ratio of (0.5-1.5), (0.4-0.6), (0.5-1.5) and (0.04-0.06).
5. The pharmaceutical composition according to claim 4, wherein the pharmaceutical composition is prepared from monkshood, asarum, brassica alba boiss, fingered citron, salvia miltiorrhiza, pepper, ginger juice and borneol in a mass ratio of 1:0.5:1:1:1:1:1: 0.05.
6. The use of the pharmaceutical composition of any one of claims 1-5 in the preparation of a Chinese medicinal acupoint patch for enhancing immune function of AIDS patients.
7. A preparation method of the traditional Chinese medicine acupoint application agent prepared from the pharmaceutical composition according to claim 1 is characterized in that monkshood, asarum, semen brassicae, fingered citron, salvia miltiorrhiza and pepper in the formula ratio are crushed and sieved by a 80-mesh sieve to obtain a material a, starch with the weight percentage of 8-12% of the material a is added with water to be prepared into paste to obtain a material b, and the material a and the material b are uniformly mixed to obtain the target traditional Chinese medicine acupoint application agent for improving the immune function of AIDS patients.
8. A preparation method of the traditional Chinese medicine acupoint application agent prepared from the pharmaceutical composition according to claim 4 is characterized in that monkshood, asarum, semen brassicae, fingered citron, salvia miltiorrhiza and pepper in formula proportion are crushed and sieved by a 80-mesh sieve to obtain a material a, starch with the weight percentage of 8-12% of the material a is added with water to be prepared into paste to obtain a material b, borneol in formula proportion is dissolved by ethanol with the weight volume of 3-5 times of that of the borneol to obtain a material c, the material a and the material b are uniformly mixed, ginger juice in formula proportion is added to be uniformly mixed, and finally the material c is added to be uniformly mixed to obtain the traditional Chinese medicine acupoint application agent for improving the immune function of AIDS patients.
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