CN107441219A - A kind of pharmaceutical composition for improving AIDS immunologic function and its application - Google Patents
A kind of pharmaceutical composition for improving AIDS immunologic function and its application Download PDFInfo
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- CN107441219A CN107441219A CN201710698539.2A CN201710698539A CN107441219A CN 107441219 A CN107441219 A CN 107441219A CN 201710698539 A CN201710698539 A CN 201710698539A CN 107441219 A CN107441219 A CN 107441219A
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- aids
- immunologic function
- pharmaceutical composition
- monkshood
- asarum
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- 208000030507 AIDS Diseases 0.000 title claims abstract description 88
- 230000036737 immune function Effects 0.000 title claims abstract description 67
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 32
- 239000003814 drug Substances 0.000 claims abstract description 55
- 238000010010 raising Methods 0.000 claims abstract description 39
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 36
- 241000227129 Aconitum Species 0.000 claims abstract description 27
- 241000758794 Asarum Species 0.000 claims abstract description 27
- 240000004307 Citrus medica Species 0.000 claims abstract description 27
- 235000001938 Citrus medica Nutrition 0.000 claims abstract description 27
- 235000002555 Citrus medica var sarcodactylis Nutrition 0.000 claims abstract description 27
- 240000007164 Salvia officinalis Species 0.000 claims abstract description 27
- 235000005412 red sage Nutrition 0.000 claims abstract description 27
- 210000000582 semen Anatomy 0.000 claims abstract description 27
- 244000089698 Zanthoxylum simulans Species 0.000 claims abstract description 24
- 239000000463 material Substances 0.000 claims description 76
- 241000234314 Zingiber Species 0.000 claims description 16
- 235000006886 Zingiber officinale Nutrition 0.000 claims description 16
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 16
- 235000008397 ginger Nutrition 0.000 claims description 16
- 229920002472 Starch Polymers 0.000 claims description 15
- 235000011837 pasties Nutrition 0.000 claims description 15
- 235000019698 starch Nutrition 0.000 claims description 15
- 239000008107 starch Substances 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 13
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims description 13
- 229940116229 borneol Drugs 0.000 claims description 13
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims description 13
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 13
- 238000009472 formulation Methods 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 6
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 claims description 3
- 240000008384 Capsicum annuum var. annuum Species 0.000 claims description 3
- 238000011282 treatment Methods 0.000 abstract description 18
- 229940079593 drug Drugs 0.000 abstract description 7
- 230000005764 inhibitory process Effects 0.000 abstract description 3
- 210000000936 intestine Anatomy 0.000 abstract description 2
- 210000002784 stomach Anatomy 0.000 abstract description 2
- 230000003612 virological effect Effects 0.000 abstract description 2
- 210000004970 cd4 cell Anatomy 0.000 description 11
- 241000725303 Human immunodeficiency virus Species 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 238000011160 research Methods 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 238000002560 therapeutic procedure Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 210000005259 peripheral blood Anatomy 0.000 description 3
- 239000011886 peripheral blood Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 206010067484 Adverse reaction Diseases 0.000 description 2
- 238000001467 acupuncture Methods 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- XPOQHMRABVBWPR-UHFFFAOYSA-N Efavirenz Natural products O1C(=O)NC2=CC=C(Cl)C=C2C1(C(F)(F)F)C#CC1CC1 XPOQHMRABVBWPR-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010021703 Indifference Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000001388 Opportunistic Infections Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 208000036981 active tuberculosis Diseases 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- XPOQHMRABVBWPR-ZDUSSCGKSA-N efavirenz Chemical compound C([C@]1(C2=CC(Cl)=CC=C2NC(=O)O1)C(F)(F)F)#CC1CC1 XPOQHMRABVBWPR-ZDUSSCGKSA-N 0.000 description 1
- 229960003804 efavirenz Drugs 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 238000013546 non-drug therapy Methods 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 229960004556 tenofovir Drugs 0.000 description 1
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 1
- 229960002555 zidovudine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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Abstract
The invention discloses a kind of pharmaceutical composition for improving AIDS immunologic function and its application.The pharmaceutical composition of described raising AIDS immunologic function includes monkshood, asarum, semen brassicae, Buddha's hand, the red sage root and Chinese prickly ash, and monkshood, asarum, semen brassicae, Buddha's hand, the mass ratio of the red sage root and Chinese prickly ash are（0.5~1.5）:（0.4~0.6）:（0.5~1.5）:（0.5~1.5）:（0.5~1.5）:（0.5~1.5）.Using application of the pharmaceutical composition for described raising AIDS immunologic function in preparing the Chinese medicine acupoint for improving AIDS immunologic function and sticking agent.The present invention is easy to operate, portable, and patient can voluntarily use；Safety, it is effectively, inexpensive, it can simultaneously be applied with treatment AIDS Western medicine HAART medicines, not increase oral dose without intestines and stomach, do not influence Western medicine to viral inhibition.
Description
Technical field
The invention belongs to pharmaceutical technology field, and in particular to it is a kind of improve AIDS immunologic function pharmaceutical composition and its
Using.
Background technology
AIDS, i.e. acquired immunodeficiency syndrome（Acquired immunodeficiency syndrome,
AIDS）, it is by human immunodeficiency virus（HIV）The infectious disease of caused chronic lethal.Current extensive use treatment HIV/
AIDS method is HAART therapies, is mainly used in combination by three kinds of antiviral drugs to treat AIDS, this therapy is in clinic
Achieve better effects, but there is also some problems, such as：Toxicity, the bad CD4 of immunologic reconstitution be chronically at reduced levels,
Resistance problems and great number medical expense for taking all the life etc., turn into a great problem of clinical research and AIDS preventing and controlling.Traditional Chinese medicine
The effort that AIDS passes through more than ten years is treated, achieves some curative effects, especially improves HIV/AIDS clinical symptoms, is mitigated
HAART adverse reactions, immunologic function is improved, improving life quality etc. has good effect, has unique advantage.So
It is obvious with the existing domestic report moxa-moxibustion energy of traditional Chinese medical science non-drug therapy treatment AIDS and Chinese traditional treatment is limited to oral drugs more at present
Improve AIDS diarrhoea clinical symptoms, but other external treatment with Chinese medicine therapies（Such as Point application）Clinical research still lack.
The content of the invention
The first object of the present invention is to provide a kind of pharmaceutical composition for improving AIDS immunologic function；Second purpose exists
In the application for the pharmaceutical composition for providing described raising AIDS immunologic function.
The first object of the present invention is achieved in that the pharmaceutical composition of described raising AIDS immunologic function includes
Monkshood, asarum, semen brassicae, Buddha's hand, the red sage root and Chinese prickly ash, monkshood, asarum, semen brassicae, Buddha's hand, the mass ratio of the red sage root and Chinese prickly ash are
（0.5~1.5）:（0.4~0.6）:（0.5~1.5）:（0.5~1.5）:（0.5~1.5）:（0.5~1.5）.
The second object of the present invention is achieved in that the pharmaceutical composition of described raising AIDS immunologic function is being made
The standby Chinese medicine acupoint for improving AIDS immunologic function sticks the application in agent.
There is traditional Chinese medicine external therapy simplicity to test honest and clean advantage, our Exploration and application acupoint application treatments since 2014
AIDS, it have received preferable clinical efficacy.Point-application is with the physiological function of traditional Chinese medical science organic conception, theory of channels and collaterals and acupuncture points on the human body
For theoretical foundation, improved by the privileged site drug absorption directly indirectly-acting of effect and acupoint stimulation stimulating Qi of meridian to reach
Body's immunity, the purpose for improving body resistance against diseases.
Yunnan is AIDS hotspot, and Kunming Traditional Chinese Medicine Hospital turns into the Grade A hospital of Yunnan and carries out traditional Chinese medicine prevention
An earliest, largest hospital of AIDS work, while the still free antiviral therapy point of country.Inventor Chen Xin is elder brother
The Ming Shi hospitals of traditional Chinese hospital AIDS head of the department, controlled from development AIDS with Traditional Chinese Medicine treatment in 2005, antiviral therapy, traditional Chinese and western medicine collaboration
The related work such as treatment and research more than 11 years, has accepted the people of HIV/AIDS patient more than 1200 for medical treatment, has presided over national, provincial level, city so far
Level scientific research task 3, has delivered the piece of professional paper more than ten, have accumulated abundant clinic and scientific research experience.Except differentiation of tcm
Outside oral traditional Chinese medicine, also try to explore and started to use TCM Features therapy in 2014（Point-application, moxa-moxibustion）Treatment
HIV/AIDS, obtain 3 Task applications.
The present invention is easy to operate, portable, and patient can voluntarily use；Safety, was correctly being grasped through the scientific research clinical test of 3 years
Occur under work without allergy, skin adverse reaction situation；Effectively, the research through 2 scientific research projects has shown that have to AIDS patient
Significantly improve immunologic function, improve the curative effects such as clinical symptoms；Inexpensive, from health economics angle, its cost is far beyond HAART
Medicine is low；It can simultaneously be applied with treatment AIDS Western medicine HAART medicines, not increase oral dose without intestines and stomach, do not influence
Western medicine is to viral inhibition.
Embodiment
With reference to embodiment, the present invention is further illustrated, but the present invention is not any limitation as in any way,
Based on present invention teach that any conversion or replacement made, belong to protection scope of the present invention.
It is of the present invention improve AIDS immunologic function pharmaceutical composition include monkshood, asarum, semen brassicae, Buddha's hand,
The red sage root and Chinese prickly ash, monkshood, asarum, semen brassicae, Buddha's hand, the mass ratio of the red sage root and Chinese prickly ash are（0.5~1.5）:（0.4~0.6）:（0.5
~1.5）:（0.5~1.5）:（0.5~1.5）:（0.5~1.5）.
The pharmaceutical composition of described raising AIDS immunologic function also includes ginger juice.
The pharmaceutical composition of described raising AIDS immunologic function also includes borneol.
Monkshood, asarum, semen brassicae, Buddha's hand, the red sage root, flower in the pharmaceutical composition of described raising AIDS immunologic function
The mass ratio of green pepper, ginger juice and borneol is（0.5~1.5）:（0.4~0.6）:（0.5~1.5）:（0.5~1.5）:（0.5~1.5）:
（0.5~1.5）:（0.5~1.5）:（0.04~0.06）.
Monkshood, asarum, semen brassicae, Buddha's hand, the red sage root, flower in the pharmaceutical composition of described raising AIDS immunologic function
The mass ratio of green pepper, ginger juice and borneol is 1:0.5:1:1:1:1:1:0.05.
The application of the pharmaceutical composition of the present invention for improving AIDS immunologic function is exempted from for described raising AIDS
Application of the pharmaceutical composition of epidemic disease function in preparing the Chinese medicine acupoint for improving AIDS immunologic function and sticking agent.
The preparation method that the Chinese medicine acupoint of described raising AIDS immunologic function sticks agent be by the monkshood of formulation ratio,
Asarum, semen brassicae, Buddha's hand, the red sage root and Chinese prickly ash crushed 80 mesh sieves and obtain material a, while take material a percentage by weights 8 ~ 12%
Starch adds water to be modulated into pasty state to obtain material b, obtains object and improve AIDS work(is immunized by material a and material b is well mixed
The Chinese medicine acupoint of energy sticks agent.
The preparation method that the Chinese medicine acupoint of described raising AIDS immunologic function sticks agent be by the monkshood of formulation ratio,
Asarum, semen brassicae, Buddha's hand, the red sage root and Chinese prickly ash crushed 80 mesh sieves and obtain material a, while take the method for material a percentage by weights 8 ~ 12%
People's starch adds water to be modulated into pasty state to obtain material b, material a and material b are well mixed, the ginger juice for adding formulation ratio mixes
Close the uniform Chinese medicine acupoint for obtaining object raising AIDS immunologic function and stick agent.
The preparation method that the Chinese medicine acupoint of described raising AIDS immunologic function sticks agent be by the monkshood of formulation ratio,
Asarum, semen brassicae, Buddha's hand, the red sage root and Chinese prickly ash crushed 80 mesh sieves and obtain material a, while take the method for material a percentage by weights 8 ~ 12%
People's starch adds water to be modulated into pasty state to obtain material b, takes the borneol of formulation ratio with after the ethanol dissolving of 3 ~ 5 times of borneol bulking value
Material c is obtained, material a and material b are well mixed, the ginger juice for adding formulation ratio is well mixed, and is eventually adding material c
The well mixed Chinese medicine acupoint for obtaining object raising AIDS immunologic function sticks agent.
So that case is embodied, the present invention will be further described below：
Embodiment 1
Monkshood 100g, asarum 80g, semen brassicae 100g, Buddha's hand 100g, red sage root 100g and Chinese prickly ash 100g are weighed, crushed 80 respectively
Mesh sieve is uniformly mixed so as to obtain material a；80g starch is weighed in addition adding water and be modulated into pasty state and obtain material b, material a and material b is mixed
The Chinese medicine acupoint for obtaining object raising AIDS immunologic function sticks agent.
Embodiment 2
Monkshood 200g, asarum 100g, semen brassicae 200g, Buddha's hand 200g, red sage root 200g and Chinese prickly ash 200g are weighed, crushed 80 respectively
Mesh sieve is uniformly mixed so as to obtain material a；100g starch is weighed in addition adding water and be modulated into pasty state and obtain material b, material a and material b are mixed
The even Chinese medicine acupoint for obtaining object raising AIDS immunologic function sticks agent.
Embodiment 3
Monkshood 300g, asarum 120g, semen brassicae 300g, Buddha's hand 300g, red sage root 300g and Chinese prickly ash 300g are weighed, crushed 80 respectively
Mesh sieve is uniformly mixed so as to obtain material a；120g starch is weighed in addition adding water and be modulated into pasty state and obtain material b, material a and material b are mixed
The even Chinese medicine acupoint for obtaining object raising AIDS immunologic function sticks agent.
Embodiment 4
Monkshood 100g, asarum 80g, semen brassicae 100g, Buddha's hand 100g, red sage root 100g and Chinese prickly ash 100g are weighed, crushed 80 respectively
Mesh sieve is uniformly mixed so as to obtain material a；80g starch is weighed in addition adding water and be modulated into pasty state and obtain material b, material a and material b are mixed
It is even, add 100g ginger juices be uniformly mixed so as to obtain object improve AIDS immunologic function Chinese medicine acupoint stick agent.
Embodiment 5
Monkshood 200g, asarum 100g, semen brassicae 200g, Buddha's hand 200g, red sage root 200g and Chinese prickly ash 200g are weighed, crushed 80 respectively
Mesh sieve is uniformly mixed so as to obtain material a；100g starch is weighed in addition adding water and be modulated into pasty state and obtain material b, material a and material b are mixed
It is even, add 100 ~ 200 ~ 300g ginger juices be uniformly mixed so as to obtain object improve AIDS immunologic function Chinese medicine acupoint stick agent.
Embodiment 6
Monkshood 300g, asarum 120g, semen brassicae 300g, Buddha's hand 300g, red sage root 300g and Chinese prickly ash 300g are weighed, crushed 80 respectively
Mesh sieve is uniformly mixed so as to obtain material a；120g starch is weighed in addition adding water and be modulated into pasty state and obtain material b, material a and material b are mixed
It is even, add 100 ~ 200 ~ 300g ginger juices be uniformly mixed so as to obtain object improve AIDS immunologic function Chinese medicine acupoint stick agent.
Embodiment 7
Monkshood 100g, asarum 120g, semen brassicae 200g, Buddha's hand 300g, red sage root 300g and Chinese prickly ash 100g are weighed, crushed 80 respectively
Mesh sieve is uniformly mixed so as to obtain material a；100g starch is weighed in addition add water and be modulated into pasty state and obtain material b, while weigh borneol 10g and add
Material c is obtained after entering the dissolving of the ethanol solution of 40ml concentration expressed in percentage by volumes 90%, then material a and material b is mixed, added
300g ginger juices, be eventually adding material c be uniformly mixed so as to obtain object improve AIDS immunologic function Chinese medicine acupoint stick agent.
Embodiment 8
Monkshood 300g, asarum 100g, semen brassicae 300g, Buddha's hand 100g, red sage root 200g and Chinese prickly ash 200g are weighed, crushed 80 respectively
Mesh sieve is uniformly mixed so as to obtain material a；120g starch is weighed in addition add water and be modulated into pasty state and obtain material b, while weigh borneol 12g and add
Material c is obtained after entering the dissolving of the ethanol solution of 50ml concentration expressed in percentage by volumes 80%, then material a and material b is mixed, added
200g ginger juices, be eventually adding material c be uniformly mixed so as to obtain object improve AIDS immunologic function Chinese medicine acupoint stick agent.
Embodiment 9
Monkshood 200g, asarum 200g, semen brassicae 200g, Buddha's hand 100g, red sage root 200g and Chinese prickly ash 100g are weighed, crushed 80 respectively
Mesh sieve is uniformly mixed so as to obtain material a；80g starch is weighed in addition add water and be modulated into pasty state and obtain material b, while weigh borneol 8g additions
Material c is obtained after the dissolving of the ethanol solution of 30ml concentration expressed in percentage by volumes 70%, then material a and material b is mixed, adds 100g
Ginger juice, be eventually adding material c be uniformly mixed so as to obtain object improve AIDS immunologic function Chinese medicine acupoint stick agent.
Embodiment 10
The Chinese medicine acupoint for the raising AIDS immunologic function being prepared below with embodiment 2 is sticked agent and tested：
Test method is as follows：
Randomized controlled trial method is taken, HIV is confirmed into the positive, CD4, which is counted, is less than 350/mm3, the age between 18 ~ 65 years old it
Between 70 patients be randomly divided into test group（The Chinese medicine acupoint for applying the raising AIDS immunologic function that example 2 is prepared sticks agent
Joint HAART）And control group（Simple HAART）.Exclude with active tuberculosis, tumour, nervous system damage and take in the recent period
With immunoregulation medicament etc. to the body's immunity person of having a great influence；With opportunistic infections, serious spirit and sacred disease
And Pregnant and lactant women.
Treatment method：
The Chinese medicine acupoint for the raising AIDS immunologic function that test group HAART+ embodiments 2 are prepared sticks agent, HAART schemes
Same control group, the Chinese medicine acupoint for the raising AIDS immunologic function that embodiment 2 is prepared stick agent and are used for big vertebra, diaphragm shu, three
5 acupuncture points such as burnt acupoint, 10h/ times, 1 times/week.The simple HAART of control group, using the free line scheme of country, medicine composition has drawing
Meter Fu Ding+Zidovudine/tenofovir+NVP/efavirenz.
Peripheric venous blood when gathering after 2 groups of patients treat the 0th, 6,12 month, uses U.S. company BD production in 7 hours
Flow cytometer measure cd4 cell absolute counting.
Curative effect：
Test group 36（HAART just controls 13, HAART >=2 year 23）, 34 simple HAART of control group（HAART just controls 9
Example, HAART >=2 year 25）.After statistics eliminates 12 incomplete with experimental data that come off, two group 70 before comparison therapy
Example demographic characteristics, no significant difference (P＞ 0.05), refer to table 1.
1 two groups of patient demographic characteristics of table compare (n, ± s)
Before enrollment, test group counts no significant difference with control group cd4 cell（t=3.709,P＞ 0.05）.Two groups
6,12 months cd4 cells count after treatment raised compared with 0 month, and wherein 6,12 months cd4 cell levels are bright after test group treatment
Aobvious horizontal higher than the control group same period, difference is statistically significant（F=10.061,P＜ 0.05）.Refer to table 2.
2 two groups of treatments 0 of table, 6,12 months cd4 cells are horizontal relatively (± s)（Individual/μ L）
Note：a：P＞ 0.05
Will HAART just control, two groups of cd4 cells of HAART >=2 year count be compared respectively, the results are shown in Table 3.
The HAART of table 3 is just controlled, >=two groups of cd4 cells of 2 years are horizontal relatively (± s)（Individual/μ L）
Note：Just control a:t=1.35,P=0.194 ；>=2 years a：t=1.323, P=0.192
The Chinese medicine acupoint for the raising AIDS immunologic function that HAART Joint Implementations example 2 is prepared is sticked the 6th, 12 after agent treatment
The cd4 cell count level of individual month is big compared with simple HAART groups ascensional range.The raising AIDS that Joint Implementation example 2 is prepared
The Chinese medicine acupoint of sick immunologic function sticks agent treatment group and simple HAART groups peripheral blood cd4 cell is counted and carried after the treatment
Rise, but the Chinese medicine acupoint of raisings AIDS immunologic function that is prepared of Joint Implementation example 2 sticks the cd4 cell counting of agent group and existed
6th, 12 months when it is horizontal obviously higher than the simple HAART groups same period, illustrate that the raising AIDS that embodiment 2 is prepared is immunized
The Chinese medicine acupoint of function sticks agent joint HAART and is better than simple HAART on the effect of lifting peripheral blood cd4 cell level.I
Same period monitoring inhibition of HIV carrying capacity change indifference with simple HAART groups compared with, illustrate that the raising that embodiment 2 is prepared ends
The Chinese medicine acupoint for growing disease immunologic function sticks agent and has no effect on inhibitory action of the HAART medicines to HIV.
Embodiment 11
Made respectively with embodiment 1, embodiment 3, embodiment 4, embodiment 5, embodiment 6, embodiment 7, embodiment 8 and embodiment 9
The Chinese medicine acupoint for the raising AIDS immunologic function that standby obtained embodiment 2 is prepared sticks agent and tested, result of the test
Show that the Chinese medicine acupoint of raising AIDS immunologic function of the present invention sticks agent joint HAART in lifting peripheral blood CD4
It is better than simple HAART on the effect of cellular level.
Claims (9)
1. a kind of pharmaceutical composition for improving AIDS immunologic function, it is characterised in that described raising AIDS immunologic function
Pharmaceutical composition includes monkshood, asarum, semen brassicae, Buddha's hand, the red sage root and Chinese prickly ash, monkshood, asarum, semen brassicae, Buddha's hand, the red sage root and flower
The mass ratio of green pepper is（0.5~1.5）:（0.4~0.6）:（0.5~1.5）:（0.5~1.5）:（0.5~1.5）:（0.5~1.5）.
2. the pharmaceutical composition according to claim 1 for improving AIDS immunologic function, it is characterised in that described raising
The pharmaceutical composition of AIDS immunologic function also includes ginger juice.
3. the pharmaceutical composition according to claim 1 or 2 for improving AIDS immunologic function, it is characterised in that described carries
The pharmaceutical composition of high AIDS immunologic function also includes borneol.
4. the pharmaceutical composition according to claim 3 for improving AIDS immunologic function, it is characterised in that described raising
Monkshood in the pharmaceutical composition of AIDS immunologic function, asarum, semen brassicae, Buddha's hand, the red sage root, Chinese prickly ash, the matter of ginger juice and borneol
Measuring ratio is（0.5~1.5）:（0.4~0.6）:（0.5~1.5）:（0.5~1.5）:（0.5~1.5）:（0.5~1.5）:（0.5~1.5）:
（0.04~0.06）.
5. the pharmaceutical composition according to claim 4 for improving AIDS immunologic function, it is characterised in that described raising
Monkshood in the pharmaceutical composition of AIDS immunologic function, asarum, semen brassicae, Buddha's hand, the red sage root, Chinese prickly ash, the matter of ginger juice and borneol
Amount is than being 1:0.5:1:1:1:1:1:0.05.
6. a kind of application of the pharmaceutical composition of any described raising AIDS immunologic function of claim 1 ~ 5, its feature exist
Sticked in the pharmaceutical composition of described raising AIDS immunologic function in the Chinese medicine acupoint for preparing raising AIDS immunologic function
Application in agent.
7. the application of the pharmaceutical composition according to claim 6 for improving AIDS immunologic function, it is characterised in that described
Raising AIDS immunologic function Chinese medicine acupoint stick agent preparation method be by the monkshood of formulation ratio, asarum, semen brassicae,
Buddha's hand, the red sage root and Chinese prickly ash crushed 80 mesh sieves and obtain material a, while take the starch of material a percentage by weights 8 ~ 12% to add water to modulate
Material b is obtained into pasty state, by the well mixed Chinese medicine acupoints for obtaining object and improving AIDS immunologic function of material a and material b
Stick agent.
8. the application of the pharmaceutical composition according to claim 6 for improving AIDS immunologic function, it is characterised in that described
Raising AIDS immunologic function Chinese medicine acupoint stick agent preparation method be by the monkshood of formulation ratio, asarum, semen brassicae,
Buddha's hand, the red sage root and Chinese prickly ash crushed 80 mesh sieves and obtain material a, while take the legal person's starch of material a percentage by weights 8 ~ 12% to add water to adjust
Pasty state is made and obtains material b, material a and material b are well mixed, the ginger juice for adding formulation ratio well mixed obtains mesh
The Chinese medicine acupoint that mark thing improves AIDS immunologic function sticks agent.
9. the application of the pharmaceutical composition according to claim 6 for improving AIDS immunologic function, it is characterised in that described
Raising AIDS immunologic function Chinese medicine acupoint stick agent preparation method be by the monkshood of formulation ratio, asarum, semen brassicae,
Buddha's hand, the red sage root and Chinese prickly ash crushed 80 mesh sieves and obtain material a, while take the legal person's starch of material a percentage by weights 8 ~ 12% to add water to adjust
Pasty state is made and obtains material b, takes the borneol of formulation ratio with material c is obtained after the ethanol dissolving of 3 ~ 5 times of borneol bulking value, will
Material a and material b are well mixed, and the ginger juice for adding formulation ratio is well mixed, and are eventually adding that material c is well mixed to be obtained
The Chinese medicine acupoint that object improves AIDS immunologic function sticks agent.
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Effective date of registration: 20240811 Address after: Room 422, Garden Building, No. 31 Yan'an North Road, Xiangcheng District, Zhangzhou City, Fujian Province 363020 Patentee after: Jiannuo Kanglai Medical Equipment Trading Co.,Ltd. in Zhangzhou City Fujian Province Country or region after: China Address before: No.25, Dongfeng East Road, Panlong District, Kunming City, Yunnan Province, 650051 Patentee before: KUNMING HOSPITAL OF TRADITIONAL CHINESE MEDICINE Country or region before: China |