CN107441056B - Film coating premix for ginseng and radix clematidis tablets, preparation method of film coating premix and ginseng and radix clematidis tablet coating method - Google Patents
Film coating premix for ginseng and radix clematidis tablets, preparation method of film coating premix and ginseng and radix clematidis tablet coating method Download PDFInfo
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- 238000009501 film coating Methods 0.000 title claims abstract description 34
- 239000007888 film coating Substances 0.000 title claims abstract description 34
- 241000208340 Araliaceae Species 0.000 title claims abstract description 31
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 title claims abstract description 31
- 235000003140 Panax quinquefolius Nutrition 0.000 title claims abstract description 31
- 235000008434 ginseng Nutrition 0.000 title claims abstract description 31
- 241000903946 Clematidis Species 0.000 title claims description 15
- 238000000034 method Methods 0.000 title claims description 11
- 238000009492 tablet coating Methods 0.000 title claims description 6
- 239000002700 tablet coating Substances 0.000 title claims description 6
- 238000002360 preparation method Methods 0.000 title description 10
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims abstract description 7
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 7
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 7
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract description 7
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 6
- 108010010803 Gelatin Proteins 0.000 claims abstract description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 5
- 229920000159 gelatin Polymers 0.000 claims abstract description 5
- 239000008273 gelatin Substances 0.000 claims abstract description 5
- 235000019322 gelatine Nutrition 0.000 claims abstract description 5
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 5
- 235000019448 polyvinylpyrrolidone-vinyl acetate copolymer Nutrition 0.000 claims abstract description 5
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 3
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 3
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 3
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 3
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 3
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 3
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 3
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 3
- 240000000171 Crataegus monogyna Species 0.000 claims abstract description 3
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 3
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 3
- 239000004349 Polyvinylpyrrolidone-vinyl acetate copolymer Substances 0.000 claims abstract description 3
- 239000003086 colorant Substances 0.000 claims abstract description 3
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims abstract description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 3
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 3
- 239000004408 titanium dioxide Substances 0.000 claims abstract description 3
- 239000003826 tablet Substances 0.000 claims description 61
- 238000000576 coating method Methods 0.000 claims description 26
- 239000011248 coating agent Substances 0.000 claims description 23
- 239000002994 raw material Substances 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 7
- 238000005507 spraying Methods 0.000 claims description 7
- 239000007941 film coated tablet Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 239000008213 purified water Substances 0.000 claims description 3
- 238000005096 rolling process Methods 0.000 claims description 3
- 238000007873 sieving Methods 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000007664 blowing Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 229940057838 polyethylene glycol 4000 Drugs 0.000 claims description 2
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 abstract description 4
- 230000000873 masking effect Effects 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 21
- 239000008298 dragée Substances 0.000 description 7
- 239000007940 sugar coated tablet Substances 0.000 description 7
- 239000000463 material Substances 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- 206010012601 diabetes mellitus Diseases 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000006188 syrup Substances 0.000 description 3
- 235000020357 syrup Nutrition 0.000 description 3
- 230000007547 defect Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000011194 good manufacturing practice Methods 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 241000756943 Codonopsis Species 0.000 description 1
- 206010041662 Splinter Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000007602 hot air drying Methods 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
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- 238000012360 testing method Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2873—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2813—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
- A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a Shenxian tablet film coating premix which comprises the following components in parts by weight: hydroxypropyl methylcellulose: 5-10 parts; 2-10 parts of medicinal gelatin; polyvinylpyrrolidone vinyl acetate copolymer: 2-5 parts; polyethylene glycol: 1-5 parts; tween 80: 1-2 parts; talc powder: 1-5 parts; titanium dioxide: 1-4 parts; colorant: 1-10 parts. The ginseng and hawthorn mixed tablet has the advantages of moisture resistance, light resistance, taste masking, wear resistance and the like, is not easy to generate splinters, spots and mildew, prolongs the effective period of medicine preservation, expands the application range of patients, and can be taken by patients who are not prone to sugar and diabetics for a long time.
Description
Technical Field
The invention relates to a coating agent, in particular to a Shenxian tablet film coating premix, a preparation method thereof and a Shenxian tablet coating method.
Background
The Shenxian tablet is a Chinese patent medicine for warming kidney, replenishing vital essence, benefiting qi and nourishing blood, and is especially suitable for treating symptoms of soreness and weakness of waist and knees and the like caused by deficiency of both kidney yin and yang and deficiency of heart qi. The ginseng and radix clematidis tablets sold on the market are generally sugar-coated tablets, but the sugar-coated tablets can increase the extra weight of the tablet core to 50-100%, and can cause great harm to human bodies after long-term use, particularly to sugar-prohibited patients and diabetic patients. And the dust generated in the production process of syrup coating is flying, the environment is easily polluted, a large space in a clean area is needed in each preparation process of sugar melting, glue melting, pigment adding, tablet airing, material storage and the like, the production process is complex, operators are mostly relied on experience in the operation process, and the operation process does not conform to the Good Manufacturing Practice (GMP). In addition, because of the uncontrollable factors in the process of coating with syrup, especially in the production and storage processes of Chinese patent medicines with strong moisture absorption, the defects of splintering, flower spots, mildew spots, over-time disintegration, difficult storage, content reduction, long production time, long tablet airing time and the like are easy to occur.
The film coating premix supplied on the market is adopted to carry out film coating on the Shenxian tablets, and the disadvantages of poor adhesive force, strong hygroscopicity, easy occurrence of cracks on the surface and the like exist. The water-based film coating premixing auxiliary material has poor moisture resistance and crack resistance, and cannot solve the problem of unstable quality caused by moisture absorption and bring great quality hidden trouble to products. The non-aqueous film coating premixing auxiliary materials need to use organic solvents, so that an explosion-proof facility has to be considered in a coating workshop, the coating workshop is also not environment-friendly, and the use cost of the solvents is obviously increased.
Therefore, those skilled in the art are working on developing an environment-friendly, simple, stable film-coating premix for ginseng tablet suitable for diabetics, a preparation method thereof and a ginseng tablet coating method.
Disclosure of Invention
In view of the above-mentioned defects of the prior art, the technical problem to be solved by the present invention is to provide an environment-friendly, simple, stable film-coating premix for ginseng tablet suitable for diabetes patients, a preparation method thereof, and a coating method for ginseng tablet.
In order to achieve the purpose, the invention provides a shenxian tablet film coating premix which comprises the following components in parts by weight:
preferably, the film coating premix for the Shenxian tablets comprises the following components in parts by weight:
the hydroxypropyl methylcellulose is preferably hydroxypropyl methylcellulose E5;
the polyethylene glycol is preferably one or two of polyethylene glycol 4000 or polyethylene glycol 6000.
The preparation method of the film coating premix for the Shenxian tablets comprises the following steps:
(1) weighing the following raw material components in parts by weight: 5-10 parts of hydroxypropyl methyl cellulose, 2-10 parts of medicinal gelatin, 2-5 parts of polyvinylpyrrolidone-vinyl acetate copolymer, 1-5 parts of polyethylene glycol, 1-2 parts of tween 80, 1-5 parts of talcum powder, 1-4 parts of titanium dioxide and 1-10 parts of colorant;
(2) adding the raw material components in the step (1) into a grinder to be ground and sieved;
(3) and uniformly mixing the crushed raw material components to prepare the film coating premix of the Shenxian tablets.
The ginseng tablet coating method using the film coating premix coating of the ginseng tablet specifically comprises the following steps:
(1) dissolving the film coating premix in purified water to prepare a solution with the weight percentage of the film coating premix being 15-20%;
(2) stirring the solution obtained in the step (1) and sieving the solution by a 100-mesh sieve;
(3) preheating a ginseng and radix clematidis tablet core to 45-50 ℃;
(4) setting the air inlet temperature of the coating machine to be 65-90 ℃ and the air outlet temperature to be 48-53 ℃;
(5) putting the sieved solution obtained in the step (2) and the radix ginseng and radix clematidis tablet core heated in the step (3) into a coating machine, and setting the spraying speed of the coating machine to be 120-20 Oml/min;
(6) after spraying is finished, continuously blowing the liquid for 5-10 minutes by using rolling hot air, and taking out;
(7) and (4) drying the tablets obtained in the step (6) at the temperature of 30-35 ℃ for 4-6 hours to obtain the ginseng and hawthorn tablet film-coated tablets.
The invention has the following beneficial effects:
① has short production period, automatic operation, no pollution to environment, and ensured worker health;
② has the advantages of reduced material consumption, increased weight, good appearance, clear mark, and no counterfeit;
③ the film coating premix is composed of high molecular compound, is nontoxic and tasteless, and can satisfy the requirement of long-term administration;
④ has advantages of moisture-proof, light-proof, taste-masking, and wear-resistant, and has advantages of low liability to generation of splinter, mottle, and mildew, and prolonged shelf life of the medicine;
⑤ is easy to disintegrate, and has improved dissolution and bioavailability;
⑥ the film coated tablet has small volume, smooth tablet shape, and easy and convenient swallowing for children and women;
⑦ it is suitable for diabetic patients and diabetic patients, and has wide application range.
Detailed Description
The present invention is further illustrated by the following examples, which are set forth to illustrate, but are not to be construed as the limit of the present invention.
The components and weights of examples 1-10 are shown in Table 1, wherein examples 1-5 are gelatin for bone preparation, and examples 6-10 are gelatin for skin preparation; the polyvinylpyrrolidone vinyl acetate copolymers of examples 1-10 were polyvinylpyrrolidone vinyl acetate copolymers (6: 4).
Table 1: examples 1-10 formulary tables
Unit: kg of
The raw material components in the embodiments 1-10 are respectively added into a pulverizer to be pulverized and sieved by a 120-mesh sieve, and the raw material components are uniformly mixed to prepare the film coating premix of the Shenxian tablets.
The film coating premix obtained in the examples 1-10 is used for coating the ginseng tablet, a proper amount of the film coating premix in each example is prepared into a solution with the weight percentage of 15-20% of the film coating premix, and 200 ginseng tablet cores are coated respectively, wherein the parameters in the coating process in each example are set as shown in the table 2.
Table 2: coating process parameter setting table
The coating is carried out by using the film coating premix of the Shenxian tablets obtained in the examples 1 to 10, and the specific steps are as follows:
(1) the film coating premixes of examples 1-10 were dissolved in purified water to prepare film coating premixes with the weight percentage of the film coating premixes as the parameters (weight percentage of the film coating premixes) in table 2;
(2) stirring the solution obtained in the step (1) and sieving the solution by a 100-mesh sieve;
(3) preheating tablet cores of the radix clematidis tablets in examples 1-10 to 45-50 ℃ according to the parameters (tablet core preheating temperature) in the table 2;
(4) setting the air inlet temperature of the coating machine in the embodiment 1-10 to be 65-90 ℃ according to the parameter (air inlet temperature of the coating machine) in the table 2, and setting the air outlet temperature to be 48-53 ℃ according to the parameter (air outlet temperature of the coating machine) in the table 2;
(5) putting the sieved solution obtained in the step (2) and the radix codonopsis and radix clematidis tablet core heated in the step (3) into a coating machine, and setting the spraying speed of the coating machine to be 120-20 Oml/min according to the parameter (spraying speed of the coating machine) in the table 2;
(6) after spraying, respectively continuing to blow the ginseng xian tablets coated in the examples 1-10 for 5-10 minutes by using rolling hot air according to the parameters (hot air drying time) in the table 2, and taking out;
(7) and (3) respectively placing the tablets obtained in the step (6) in a drying room with the parameters (drying room temperature) set in the table 2, and drying for 4-6 hours according to the parameters (drying room drying time) in the table 2 to respectively obtain the ginseng tablet film-coated tablets of the examples 1-10.
The preparation method is characterized in that comparative examples 1-10 are additionally arranged, 200 ginseng xianxian tablet core tablets are arranged in each comparative example, the ginseng xianxian tablet core tablets adopted in the examples and the comparative examples are produced in the same batch, the weight error is not more than 0.3 per thousand, and the ginseng xianxian tablets are coated by adopting traditional syrup in the comparative examples.
After all the ginseng radix and immortal tablets are coated, 100 tablets of film-coated tablets of practical examples 1-10 and sugar-coated tablets of comparative example of ginseng radix and immortal tablets are weighed, and the weight change of the coated ginseng radix and immortal tablets is shown in table 3 relative to tablet cores of the plain tablets.
Table 3: tables for weight changes after coating for examples 1 to 10 and comparative examples 1 to 10
| Examples | Weight increase ratio (%) | Comparative example | Weight increase ratio (%) |
| Example 1 | 3.33 | Comparative example 1 | 82.56 |
| Example 2 | 4.58 | Comparative example 2 | 79.33 |
| Example 3 | 3.07 | Comparative example 3 | 90.67 |
| Example 4 | 4.92 | Comparative example 4 | 64.51 |
| Example 5 | 3.53 | Comparative example 5 | 72.38 |
| Example 6 | 3.67 | Comparative example 6 | 54.93 |
| Example 7 | 3.01 | Comparative example 7 | 91.52 |
| Example 8 | 4.02 | Comparative example 8 | 89.98 |
| Example 9 | 3.56 | Comparative example 9 | 86.53 |
| Example 10 | 3.17 | Comparative example 10 | 74.67 |
| Example mean values | 3.69 | Average of comparative examples | 78.71 |
From the tests, the ginseng and radix clematidis tablet is coated, the weight of the tablet core is only increased by 3% -5%, the average weight is increased by 75.02% compared with the weight of the traditional sugar-coated tablet, the coating materials are saved, and the film-coated tablet is smaller than the sugar-coated tablet in volume and is more convenient to carry.
The film-coated ginseng tablets of examples 1 to 10 and the sugar-coated tablets of comparative examples 1 to 10 were placed in the same natural environment, and the breakage, swelling and mildew were observed and recorded every day until day 90, and the breakage rate, moisture absorption rate and mildew rate were shown in table 4.
Table 4: tables for changes in tablets of examples 1 to 10 and comparative examples 1 to 10
By comparing the examples with the comparative examples, after the radix clematidis tablet is coated by the film coating premix and the coating method for the radix clematidis tablet, the breakage rate of the radix clematidis tablet is obviously reduced, the moisture absorption rate is greatly reduced, and the mildew rate is controlled below 1 percent. Compared with sugar-coated tablets, the film-coated Shenxian tablets have better quality and lower storage requirement. In a word, the application of the invention ensures that the storage and transportation of the Shenxian tablets are more efficient and simpler.
The foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.
Claims (4)
1. A Shenxian tablet film coating premix is characterized in that: the composition comprises the following components in parts by weight:
wherein the hydroxypropyl methylcellulose is hydroxypropyl methylcellulose E5;
the polyethylene glycol is one or two of polyethylene glycol 4000 or polyethylene glycol 6000.
2. The film-coated premix for Shenxian tablet as claimed in claim 1, which is characterized in that: the composition comprises the following components in parts by weight:
3. the process for preparing the film-coated premix of Shenxian tablet as claimed in claim 1, wherein: the method comprises the following steps:
(1) weighing the following raw material components in parts by weight: 5-10 parts of hydroxypropyl methyl cellulose, 2-10 parts of medicinal gelatin, 2-5 parts of polyvinylpyrrolidone-vinyl acetate copolymer, 1-5 parts of polyethylene glycol, 1-2 parts of tween 80, 1-5 parts of talcum powder, 1-4 parts of titanium dioxide and 1-10 parts of colorant;
(2) adding the raw material components in the step (1) into a grinder to be ground and sieved;
(3) and uniformly mixing the crushed raw material components to prepare the film coating premix of the Shenxian tablets.
4. A ginseng tablet coating method is characterized in that: the film-coated premix coating of the shenxian tablet as claimed in claim 1, comprising the following steps:
(1) dissolving the film coating premix in purified water to prepare a solution with the weight percentage of the film coating premix being 15-20%;
(2) stirring the solution obtained in the step (1) and sieving the solution by a 100-mesh sieve;
(3) preheating a ginseng and radix clematidis tablet core to 45-50 ℃;
(4) setting the air inlet temperature of the coating machine to be 65-90 ℃ and the air outlet temperature to be 48-53 ℃;
(5) putting the sieved solution obtained in the step (2) and the radix ginseng and radix clematidis tablet core heated in the step (3) into a coating machine, and setting the spraying speed of the coating machine to be 120-200 ml/min;
(6) after spraying is finished, continuously blowing the liquid for 5-10 minutes by using rolling hot air, and taking out;
(7) and (4) drying the tablets obtained in the step (6) at the temperature of 30-35 ℃ for 4-6 hours to obtain the ginseng and hawthorn tablet film-coated tablets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710573252.7A CN107441056B (en) | 2017-07-14 | 2017-07-14 | Film coating premix for ginseng and radix clematidis tablets, preparation method of film coating premix and ginseng and radix clematidis tablet coating method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710573252.7A CN107441056B (en) | 2017-07-14 | 2017-07-14 | Film coating premix for ginseng and radix clematidis tablets, preparation method of film coating premix and ginseng and radix clematidis tablet coating method |
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| Publication Number | Publication Date |
|---|---|
| CN107441056A CN107441056A (en) | 2017-12-08 |
| CN107441056B true CN107441056B (en) | 2020-03-17 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101120953A (en) * | 2006-08-10 | 2008-02-13 | 上海新菲尔生物制药工程技术有限公司 | Complete water type thin film coating pre-mixture for traditional Chinese medicine tablets |
| CN101467978A (en) * | 2007-12-29 | 2009-07-01 | 谭光明 | Complete-water stomach dissolved type moisture-proofing film coating premix |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101120953A (en) * | 2006-08-10 | 2008-02-13 | 上海新菲尔生物制药工程技术有限公司 | Complete water type thin film coating pre-mixture for traditional Chinese medicine tablets |
| CN101467978A (en) * | 2007-12-29 | 2009-07-01 | 谭光明 | Complete-water stomach dissolved type moisture-proofing film coating premix |
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