CN107421981B - A kind of small temp difference measurer - Google Patents
A kind of small temp difference measurer Download PDFInfo
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- CN107421981B CN107421981B CN201710063812.4A CN201710063812A CN107421981B CN 107421981 B CN107421981 B CN 107421981B CN 201710063812 A CN201710063812 A CN 201710063812A CN 107421981 B CN107421981 B CN 107421981B
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- heat
- heat sensor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N25/00—Investigating or analyzing materials by the use of thermal means
- G01N25/20—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity
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- Investigating Or Analyzing Materials Using Thermal Means (AREA)
Abstract
Plate is used the invention patent relates to a kind of, the small temp difference measurer of sheet heat sensor, by twin heat sensor, constant temperature is heat sink, temperature-sensitive cavity, thermal insulation supporter, thermal insulation gland, flow into duct and outflow duct composition, one side end face of heat sensor and constant temperature are heat sink thermally contact it is good, another side end face is temperature-sensitive cavity, the connection of temperature-sensitive cavity flows into duct and outflow duct, it realizes to go out in tripping in, the thermal stability of overall structure and arrangement is good, it can be convenient combination, structure is simple, compactedness is good, high degree of automation, realize reference measurement, eliminate non-specific heat interference, high sensitivity, there is advantage applied to field assay and test, it can apply in various thermometric analysis, the fields such as calorimetric biosensor.
Description
Technical field
The present invention relates to a kind of small temp difference measurers, in particular by plate, the small differential temperature survey of sheet heat sensor
Device can be applied in fields such as various thermometric analysis, calorimetric biosensors.
Background technique
Thermometric analysis method is analyzed by testing the thermal change of biochemical reaction process, is suitable for most of
Biochemical reaction is not influenced by sample properties such as color, muddiness and electrochemistry, and the testing principle of calorimetric method it is simple, can
It leans on, is increasingly becoming the important directions that exploitation is quickly detected in the fields such as food safety, environment, medicine.It is quick by the biology such as desmoenzyme
The calorimetric biosensor of sensing unit can greatly improve the specificity of calorimetry, and speed is surveyed and on-line analysis field at the scene
With advantage, it is particularly suitable for detecting untreated actual sample.
The useful signal of thermometric analysis method is thermal change, and the different complicated thermal signals of real process coexist, and it is filled
Set have the characteristics that various structure types and.Current heat sensor (temperature sensor, heat flow transducer etc.) is mainly temperature-sensitive electricity
Resistance and thermoelectric pile, there is plate, sheet, column, pearl and the forms such as spherical, and individual heat sensor is not able to satisfy different calorimetrics point
The measurement request of analysis apparatus and complicated thermal signal requires the own characteristic for adapting to apparatus for thermal analysis, heat sensor, guarantees heat
Stability is good and heat transfer is well arranged, and high sensitivity, realizes reference measurement etc..Small temp difference measurer adapts to above-mentioned want
It asks, by the variation of heat sensor timely perception studies object temperature and heat, structure arrangement is able to satisfy different thermometric analysis and wants
Summation heat sensor design feature (contact need plane or immerse arrangement form etc.) can guarantee strong heat exchange, thermostabilization and sensitive
Degree is high, and compact-sized, adaptable.
Summary of the invention
Present invention aim to address in existing thermometric analysis and calorimetric biosensor thermal parameter measurement technology lack
It falls into, provides a kind of using plate, the small temp difference measurer of sheet heat sensor.
The technical solution adopted by the present invention to solve the technical problems is that small temp difference measurer is passed by heat sensor A, heat
Sensor B, constant temperature are heat sink, temperature-sensitive cavity, thermal insulation supporter, thermal insulation gland, flow into duct and outflow duct composition, the heat
Sensors A and the heat sensor B are twin heat sensors, are the contact heat sensors of plate and sheet form, preferably
A side end face of sheet thermoelectric pile, the heat sensor A and the heat sensor B are hot end face, and another side end face is cold end face,
Phase the same side end face of the heat sensor A and the heat sensor B and the constant temperature are heat sink to thermally contact good, the identical other side
End face is the temperature-sensitive cavity, and the temperature-sensitive cavity connects the inflows duct and the outflow duct, the inflow duct with
The relative position in the outflow duct guarantees that flowing is to go out in tripping in, and built-in thermostat module that the constant temperature is heat sink is, it can be achieved that controllable
Temperature constant state, the constant temperature is heat sink be rotary table form metal block, side be processed into plane and respectively with the heat sensor A
It is well thermally contacted with the heat sensor B, pit, the built-in heat sensor A, the heat is provided on the thermal insulation supporter
Sensor B and the constant temperature are heat sink, and the thermal insulation gland is placed on the thermal insulation supporter, guarantee the heat sensor A,
The heat sensor B and the constant temperature are heat sink with environment thermal insulation, and the signal of the heat sensor A and the heat sensor B are defeated
It is concatenated out according to difference output mode.
The thermal insulation supporter and the thermal insulation gland are made of high chemically inert heat insulator, preferably poly-
Tetrafluoroethene (hydrophilic modification).
Further, the heat sensor A and heat sensor B is one group of measurement respectively as measurement and reference composition
Channel and reference channel, Measurement channel and the reference channel of being such as multiplied simultaneously are, it can be achieved that measurement while multiple groups channel.
The invention has the advantages that small temp difference measurer structure arrangement adapts to the knot of heat sensor and apparatus for thermal analysis
Structure feature, it is more convenient using highly sensitive heat sensor, improve the signal strength of small differential temperature survey, high sensitivity；Realize ginseng
Than measurement, what is obtained is difference component, eliminates non-specific heat interference, improves measurement accuracy；It can be convenient combination, be able to achieve multichannel
It is measured while channel；The thermal stability of overall structure and arrangement is good, can reduce environmental disturbances, reduces error；Structure letter
Single, cheap, compactedness is good, high degree of automation, and adaptability is good, and being applied to field assay and test has advantage.
Detailed description of the invention
Present invention will be further explained below with reference to the attached drawings and examples.
Fig. 1 is small temp difference measurer structural schematic diagram.
Fig. 2 is the structural schematic diagram of small temp difference measurer binding reactor.
Wherein: 1, heat sensor A, 2, heat sensor B, 3, constant temperature is heat sink, 4, temperature-sensitive cavity, 5, thermal insulation supporter, 6,
Thermal insulation gland, 7, inflow duct, 8, outflow duct.
Specific embodiment
Present invention combination nationality by below in conjunction with embodiment illustrate the content of the present invention, the model being not intended to limit the present invention
It encloses.
As shown in Figure 1, small temp difference measurer by heat sensor A1, heat sensor B2, constant temperature is heat sink 3, temperature-sensitive cavity 4,
Thermal insulation supporter 5, thermal insulation gland 6 flow into duct 7 and outflow duct 8 and form, and heat sensor A1 and heat sensor B2 are twin
Heat sensor selects the consistent sheet thermoelectric pile of performance structure, is provided with pit in thermal insulation support 5, for built-in heat sensing
The hot end face of device A1, heat sensor B2 and constant temperature heat sink 3, heat sensor A1 and heat sensor B2 and heat sink 3 side of constant temperature are close
Contact, and smear heat-conducting silicone grease and reduce thermal contact resistance, the cold end face of heat sensor A1 and heat sensor B2 are respectively overlay in pit
The temperature-sensitive cavity 4 outputed, and being directly bonded in thermal insulation support 5, heat sensor A1, heat sensor B2 be and temperature-sensitive when measurement
Reaction solution in cavity 4 directly contacts, and temperature-sensitive cavity 4 is the circular cylindrical cavity with a thickness of 2-5mm, and lateral opening hole connects inflow hole
Road 7 and outflow duct 8, thermal insulation support 5 lower disposeds to have the protrusion of semicolumn hemicone, are used as and flow into along raised axle center aperture
Duct 7, outflow duct 8 support 5 horizontal bores to obtain in thermal insulation, and relative position, which is higher than, flows into duct 7, guarantee that flowing is tripping in
It is upper go out, constant temperature is heat sink 3 be rotary table form metal block, upward, embedded semiconductor refrigerating/heating module is, it can be achieved that can for bottom surface
The temperature constant state of control, constant temperature is heat sink, and 3 sides are processed into plane and are in close contact respectively with heat sensor A1 and heat sensor B2, heat
Thermal insulation gland 6 is placed on 5 top of insulation support body, guarantees that heat sensor A1, heat sensor B2 and constant temperature heat sink 3 are exhausted with ambient heat
The signal output of edge, heat sensor A1 and heat sensor B2 are concatenated according to difference output mode.Thermal insulation supporter 5 and thermal insulation
Gland 6 is made of polytetrafluoroethylene (PTFE) (hydrophilic modification).
It is arranged on supporter using two small temp difference measurers of twinned structure and twin heat sensor and forms one group of survey
It pings and reference channel, as shown in Fig. 2, by the end socket of the protrusion insertion microresponse device outlet on thermal insulation supporter 5,
Guarantee that runner is closed, wherein a reactor is reference reaction device, another reactor is test reactor, and sample is logical in test
It is reacted in the test reactor in road, and is not reacted in reference reaction device, so that the two, there is the temperature difference, the temperature difference becomes
The size of change is detected by being placed on the small temp difference measurer of reactor outlet, the twin heat sensing of small temp difference measurer
The signal output of device is concatenated according to difference output mode, the temperature signal of test reactor and reference reaction device is obtained, through handling
It can reflect the extent of reaction and concentration of sample afterwards.
Claims (4)
1. a kind of small temp difference measurer, by heat sensor A(1), heat sensor B(2), constant temperature is heat sink (3), temperature-sensitive cavity (4),
Thermal insulation supporter (5), thermal insulation gland (6) flow into duct (7) and outflow duct (8) composition, which is characterized in that the heat
Sensors A (1) and the heat sensor B(2) it is twin heat sensor, it is the contact heat sensor of plate or sheet form,
The heat sensor A(1) and the heat sensor B(2) phase the same side end face thermally contacted well with the constant temperature heat sink (3),
Identical another side end face is the temperature-sensitive cavity (4), and the temperature-sensitive cavity (4) connects the inflow duct (7) and the outflow
Duct (8), the relative position guarantee flowing for flowing into duct (7) and outflow duct (8) is to go out in tripping in, the constant temperature
Heat sink (3) are the metal block of rotary table form, and side is processed into plane and is sensed respectively with the heat sensor A(1) and the heat
Device B(2) good thermo-contact, be provided with pit, the built-in heat sensor A(1 on the thermal insulation supporter (5)), the heat passes
Sensor B(2) and the constant temperature it is heat sink (3), place the thermal insulation gland (6) on the thermal insulation supporter (5), the heat passes
Sensor A(1) and the heat sensor B(2) signal output concatenated according to difference output mode.
2. a kind of small temp difference measurer according to claim 1, it is characterised in that the heat sensor A(1) and it is described
Heat sensor B(1) it is sheet thermoelectric pile.
3. a kind of small temp difference measurer according to claim 1, it is characterised in that constant temperature built in the constant temperature heat sink (3)
Module is, it can be achieved that controllable temperature constant state.
4. a kind of small temp difference measurer according to claim 1, it is characterised in that the thermal insulation supporter (5) and institute
Thermal insulation gland (6) is stated to be made of high chemically inert heat insulator.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710063812.4A CN107421981B (en) | 2017-02-04 | 2017-02-04 | A kind of small temp difference measurer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710063812.4A CN107421981B (en) | 2017-02-04 | 2017-02-04 | A kind of small temp difference measurer |
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| Publication Number | Publication Date |
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| CN107421981A CN107421981A (en) | 2017-12-01 |
| CN107421981B true CN107421981B (en) | 2019-11-05 |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110794894A (en) * | 2019-10-31 | 2020-02-14 | 中国原子能科学研究院 | Solid-state constant temperature device for controlling temperature of outer surface of calorimeter |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101042359A (en) * | 2006-03-21 | 2007-09-26 | 仕富梅集团公司 | Thermal conductivity sensor |
| CN102620590A (en) * | 2012-03-30 | 2012-08-01 | 中国科学院工程热物理研究所 | Micro-channel heat sink and performance testing device thereof |
| CN103196952A (en) * | 2013-04-07 | 2013-07-10 | 青岛大学 | Calorimetric method for detecting pesticides by using acetylcholin esterase |
| CN103235006A (en) * | 2013-04-07 | 2013-08-07 | 青岛大学 | Calorimetric detection apparatus for acetone in breathing gas |
-
2017
- 2017-02-04 CN CN201710063812.4A patent/CN107421981B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101042359A (en) * | 2006-03-21 | 2007-09-26 | 仕富梅集团公司 | Thermal conductivity sensor |
| CN102620590A (en) * | 2012-03-30 | 2012-08-01 | 中国科学院工程热物理研究所 | Micro-channel heat sink and performance testing device thereof |
| CN103196952A (en) * | 2013-04-07 | 2013-07-10 | 青岛大学 | Calorimetric method for detecting pesticides by using acetylcholin esterase |
| CN103235006A (en) * | 2013-04-07 | 2013-08-07 | 青岛大学 | Calorimetric detection apparatus for acetone in breathing gas |
Non-Patent Citations (2)
| Title |
|---|
| 用于有机磷农药残留快速检测的酶法量热式流动注射分析检测仪;郑艺华;《仪器仪表学报》;20050731;第26卷(第7期);第733-737页 * |
| 量热式酶生物传感器及其环境监测应用;郑艺华;《安全与环境学报》;20101031;第10卷(第5期);全文 * |
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