CN107412385A - It is a kind of to be used to treat Chinese medicine composition of nettle rash and preparation method thereof - Google Patents
It is a kind of to be used to treat Chinese medicine composition of nettle rash and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of Chinese medicines, and in particular to a kind of to be used to treat Chinese medicine composition of nettle rash and preparation method thereof.For treating the Chinese medicine composition of nettle rash, include the raw material components of following parts by weight：30~60 parts of Os Draconis, 20~40 parts of calcined oyster shell, 10~30 parts of divaricate saposhnikovia charcoal, 20~40 parts of charred RADIX SANGUISORBAE, 10~30 parts of madder and 20~40 parts of the capsule of weeping forsythia.The traditional Chinese medicine composition for treating nettle rash of the present invention is evident in efficacy, and cure rate is high；Flavour of a drug number is few, and cost is low；Preparation method receives modern machines to decoct the advantages of machine encapsulates on the basis of passing on traditional-handwork and boiling medicine, and can extend the shelf-life of decoction of medicinal ingredients；Pure Chinese medicinal preparation, toxic side effect is small, safe；Aviod certain food without patient, reduce patient suffering's degree, increase immunity.
Description
Technical field
The invention belongs to the field of Chinese medicines, and in particular to a kind of Chinese medicine composition and its making side for being used to treat nettle rash
Method.
Background technology
Nettle rash is due to that a kind of localized edema that skin, the expansion of mucous membrane thin vessels and permeability strengthen and occurred is anti-
Should, it is a kind of clinical more typical mucocutaneous anaphylactia.Most nettle rash are as caused by anaphylaxis mechanism.Food
In anaphylactogen (belonging to foreign protei matter more) stimulate human body, make human body produce specific antibody IgE (immunoglobulin E), it is this
On IgE antibody attachment mast cell in vivo or on basophil, when eating this food again, IgE antibody is just and food
Anaphylactogen in thing is combined, so that mast cell and basophil release histamine.Histamine and vasoactive,
Expansion and permeability increase are allowed to, thus a large amount of protein and intravenous extravasation then produce nettle rash into skin histology.This category
In I type allergic reactions.It is more to belong to the nettle rash of this mechanism, it is most common to have the animal proteins such as mutton, fish, shrimp.It is interior
Clothes or the medicine of injection, mycotic spore, pollen and chemical substance present in air are inhaled into, various infection or infectious lesionses
Product etc..In addition, nonallergic histamine releasing can also cause nettle rash.As some drugses (aspirin, morphine, sulfanilamide (SN),
Penicillin, atropine etc.), some other is biological, chemically and physical factor, can directly act on mast cell, make it
Release histamine causes nettle rash, it is not necessary to passes through anaphylaxis mechanism.In addition, warm, motion, excited etc. can make autonomous god
Cholinergy nerve endings release acetylcholine through system.Acetylcholine can directly cause blood vessel dilatation, can also promote tissue
Amine discharges, and triggers nettle rash.It can be seen that the occurrence and development of nettle rash are probably the result of Different types of etiopathogenises synergy.
Doctor trained in Western medicine there is no specific treatment method to chronic urticaria at present, more based on the symptomatic treatments such as antihistamine drug, though
Temporary relief of symptoms, but easily form medicine accordance with tolerance and drug therapy is resisted, it is discontinued and recurs, late result is bad.And should
Class medicine is mostly unsuitable long-term use of, and antihistamine has certain cardiac toxic, and causes the side effect of drowsiness reaction.In addition,
All there is drug resistance in any antiallergic, patient takes a kind of antiallergic for a long time, it may appear that drug effect decline, can not
Play the phenomenon of anti-allergic effects.Therefore, should not long-term use of same medicine when taking antiallergic.
Record without " nettle rash " this name of disease in Chinese medical book, but nettle rash belongs to equivalent to " urticaria " of traditional Chinese medicine
The dermopathic category of wind class.See earliest《The Shi Ci roads of Plain Questions four are from opinion》：" few the moon is had a surplus, sick numbness of the skin urticaria." " ailment said due to cold or exposure visitor in
Then flesh is empty in flesh, and vital qi diverging is fought by cold again, skin outgoing opening of sweat pores hair, and the excessive absurd row of gas is then to itch.So there is rubella
Itch, all due to this.There is red rash person again, play sciniph such as suddenly and peck, the tired pole person that itches, repetitious ridge is risen, and that scratches rises by hand.There is white rash again
Person, also so.Sent out during red rash heat, it is cold to stop.Sombrely send out in white rash day." Sui《General Treatise on the Cause and Symptoms of Diseases wind scabies urticaria is waited》：
" because sweat, solution skirt are undressed, wind enters space between skin and muscles and mutually fought with qi and blood children, and knot, which has gathered, is connected to urticaria, general mood, its gesture superficial in space between skin and muscles
It is micro-, therefore pneumonedema is not bitterly, but into urticaria itch ear.”《General Treatise on the Cause and Symptoms of Diseases wind scabies body urticaria is waited》Cloud again：" perverse trend visitor in skin,
Chill is met mutually to roll over again, then the scabies that blows urticaria." Song《General Records of Holy Universal Relief》：" opinion says wind scabies urticaria, and its shape has two, all had in edge flesh
Heat.If cool wet gas rolls over it, thermojunction does not dissipate, then into white gizzard.If because ailment said due to cold or exposure is rolled over, wind-heat is mutually fought, then into red gizzard.Red gizzard obtain it is hot then
Play, obtains cold, goes out, and the pent-up of lid hot gas is in interior therefore to dislike heat preferably cold.White gizzard obtain it is overcast and rainy what for, obtain fine warm and sunny, disappear, lid hot gas dissipate release in
Outside, therefore dislike cold preferably heat, though cold and hot card is different, it is urticaria then one, lid body wind scabies and itch, scabies indistinctly is.Control wind
Scabies urticaria, that scratches whips, and pain of itching is unhappy.Mahuang Tang side." clear《Yizong Jinjian, surgery heart method gist》Cloud：" this card popular name
Urticaria, crouched and enjoyed the cool by sweating wind-engaging, or dew, the people of exterior deficiencys during ailment said due to cold or exposure is more.
The reason for traditional Chinese medical science thinks, natural endowment is intolerant to being one of this disease extremely important, natural endowment intolerant to, once run into extraneous allergy
The stimulation of factor, then it can send out as this disease；Ailment said due to cold or exposure is to cause the most common exopathogen of this disease, " wind being primary pathogen ", ailment said due to cold or exposure again often with
Cold-evil or heat evil are mutually simultaneous, win and are sent out in skin space between skin and muscles as this disease；Because eating pungent, raw meat hair thing on diet, retention of damp-heat in the interior is caused, changes heat
Dynamic wind, " interior must not catharsis, must not reach thoroughly outside, strongly fragrant between skin space between skin and muscles " and fall ill；The emotional factors such as stress, anxiety,
Viscera function can be made to lack of proper care, yin and yang imbalance, battalion, which defends, to become estranged, and sends out as this disease；After ferritic weakness or serious disease, prolonged illness, deficient qi and blood,
The deficiency of vital energy then take advantage of a weak point by weakened defensive QI, ailment said due to cold or exposure, the deficiency of blood then empty hot air wind producing, and skin is not normal and to send out be this disease.
General traditional Chinese and western medicine suggests patient management diet 3-6 individual month during chronic urticaria treat, with vegetarian diet and non-
Based on stimulating food diet, drink tea less with beverage etc., establish the diet archives of oneself daily, voluntarily exclude possible allergenic foods or
Eating habit.
The content of the invention
In order to using the elite of Traditional Chinese medical theory, reach the purpose for the treatment of nettle rash, the invention provides one kind to be used for
The Chinese medicine composition of nettle rash is treated, includes the raw material components of following parts by weight：30~60 parts of Os Draconis, 20~40 parts forge
Oyster, 20~40 parts of the capsule of weeping forsythia, 10~30 parts of divaricate saposhnikovia charcoal, 20~40 parts of charred RADIX SANGUISORBAE and 10~30 parts of madder.
Monarch drug in a prescription Os Draconis are recorded in earliest in side《This warp》, its property sweet-puckery flavor, put down, enter the heart, liver, kidney, large intestine channel, there is important city
Calm the nerves tranquillizing the mind by relieving convulsion, arrest sweating controlling nocturnal emission with astringent drugs, stop blooding puckery intestines, the effect of myogenic sore.Keel mainly contain calcium carbonate (CaCO3) and phosphoric acid
Calcium [Ca3(PO4)2], still iron content, potassium, sodium, chlorine, sulfate radical etc..Modern pharmacology shows that it can promote blood clotting, and it is penetrating to reduce vascular wall
Property and suppress skeletal muscle excitation.
Calcined oyster shell tranquilizing mind, nourishing and suppressing Yang are minister.Calcined oyster shell is recorded in earliest《This warp》, its nature and flavor is salty, is slightly cold, and enters
Liver, kidney channel.There are transquilization with heavy material, checking exuberance of yang tonifying yin, the astringent or styptic treatment for spontaneous sweating effect of softening and resolving hard mass, convergence.Oyster calcium carbonate more than 90%, and it is phosphorous
Sour calcium, calcium sulfate.Human body Ca ion concentrations can be effectively improved by being shared with Os Draconis, promoted function of immune system stable, reduced
Quick reaction.
Divaricate saposhnikovia charcoal is windproof Preparation process product.It is windproof to come from《This warp》, nature and flavor acrid, sweet, warm, return bladder, liver, the spleen channel,
There is inducing diaphoresis to dispel wind, victory is wet, only the effect of convulsion.《Japan hanako materia medica》：" wind as 36 is controlled, all labor of man are bad, bowl spares benefit god,
Blepharitis marginalis, only tear and paralysis are slow, tonneau the five internal organs Guan pulse, general debility, thin damage night sweat, vexed body weight, energy tranquilizing the mind, even gaseous pulse.”
It is windproof to contain volatile oil, mannitol, bitter taste glucoside etc..Divaricate saposhnikovia charcoal only have expelling wind and eliminating dampness, can also clearing heat and cooling blood, wind-dispelling hemostasis, protect liver.
Charred RADIX SANGUISORBAE is the Preparation process product of garden burnet.Garden burnet is come from《This warp》, it is bitter in taste, cold, Return liver, large intestine channel, there is cool blood
Hemostasis, the effect of removing toxic substances sore.《Do not record》：" only purulence blood, all fistulas, malignant sore, disappear wine, except quenching one's thirst, mends wound absolutely, fills in, can make in postpartum
Metal-inflicted wound cream." modern pharmacology show charred RADIX SANGUISORBAE can stop blooding, anti-inflammatory, antibacterial, promote wound healing.
Madder is come from《This warp》, it is bitter in taste, tremble with fear, return liver warp, there is cool blood, stop blooding, dissolving stasis, the effect of stimulating the menstrual flow.《This warp》：
" control cold-dampness wandering arthritis, jaundice, bowl spares." modern pharmacology show madder have hemostasis, platelet aggregation-against, antibacterial, increasing leukocyte,
Suppress the effect of skin connective tissue permeability.
Assistant in divaricate saposhnikovia charcoal, charred RADIX SANGUISORBAE, the medicine phases side of being combined into of madder three, plays cooling blood and hemostasis altogether, and hemostasis is overflow and changes the work(of the old stasis of blood
Effect.
The capsule of weeping forsythia is to make in side, and its is bitter in taste, is slightly cold, return lung, the heart, small intestinl channel, there is clearing heat and detoxicating, the work(of dispersing swelling and dissipating binds
Effect.《This warp》：" main fever and chills, mouse impotence, scrofula, Carbuncle swells dislikes sore, goiter and tumor, knot heat." Li Gao think the capsule of weeping forsythia have " dissipate all menses knot gas
It is poly-, detumescence." the effect of.The capsule of weeping forsythia is containing forsythol, sterol compound, saponin (no hemolytic) and Flavonoids, horse tongue resinol
Glucoside etc..Modern pharmacology shows that the capsule of weeping forsythia plays the role of antibacterial, mitigates inflammatory mediator reaction, reduces inflammatory factor and disengages.
All medicine phases are closed in side, and it is antipruritic to play tranquilizing mind altogether, the effect of cooling blood and hemostasis, make Xinshen Ning, blood vessels peace, and itch is stopped,
Skin must support.
Traditional Chinese medicine thinks that nettle rash is mainly caused a disease by exogenous wind, more damp and hot by interspaces of skin and muscles being loose, or stomach and intestine, feels exopathogen again, visitor in
Fleshy exterior, battalion is caused to defend imbalance and send out.Shamanism instructed the sutra further exploration, it is believed that nettle rash be " perverse trend visitor is disharmony between ying and wei in skin,
Outer fall is defended, causes Xue Buxunchang roads, overflows outside arteries and veins, ties in fleshy exterior, and sends out urticaria, induced pain causes to itch.It is the sick disease outside the excessive arteries and veins of blood
Machine, and the fundamental basis that treatment is seted forth one's views.《Plain Questions menstruation regulating opinion》There is " vim and vigour are got along well, and all kinds of diseases and ailments are change and given birth to ", " disease in blood,
The network of tune ", with reference to modern medicine " nettle rash be skin and mucosa thin vessels reactivity expansion and permeability increase and caused one
The theory of kind localized edema reaction ", it is considered herein that treatment nettle rash, it is key to improve vascular function, reduce inflammatory and ooze out.
Technical solution of the present invention is developed for this, prescription conception focuses on treated form blood.Original creation is based on antipruritic, blood-stanching and blood-cooling of calming the nerves, stagnation resolvation
Supplemented by theory, i.e. blood overflows first, and blood stasis is rear.In side reuse Os Draconis it is transquilization with heavy material it is antipruritic be monarch；Calcined oyster shell is minister, enriching yin
Checking exuberance of yang enhancing important city checking exuberance of yang, antipruritic effect of calming the nerves；Divaricate saposhnikovia charcoal, charred RADIX SANGUISORBAE, madder are assistant, play the product of blood-stanching and blood-cooling altogether, and hemostasis is overflow
And change the work(of the old stasis of blood；The capsule of weeping forsythia has the effect of clearing heat and detoxicating, dispersing swelling and dissipating binds to make.All medicines share, the few power of medicine is special, Xinshen Ning, blood vessels
Peace, itch are stopped, and skin must support.Modern pharmacological research shows that Os Draconis, calcined oyster shell are pure natural biological similar drug, containing rich
A variety of human body institutes such as rich calcium salt and magnesium, iron, copper, manganese, zinc, selenium must element.Calcium salt removes to human body calm, anticonvulsion etc. make
With outer, capillary permeability can also be reduced, blood clotting can be promoted, prevents leucocyte and serum from oozing out outside blood vessel, is suppressed
The release of inflammatory factor, so as to suppress inflammatory reaction.Divaricate saposhnikovia charcoal, charred RADIX SANGUISORBAE anastalsis substantially increase compared with health product, can shorten
Blood time and clotting time.Madder can substantially shorten the clotting time, and can embody the spy that the stasis of blood is not stayed in hemostasis to platelet aggregation-against
Point.The capsule of weeping forsythia has the function that antibacterial, can prevent from infecting caused by the skin of breakage.All medicines share, supplement human body is calcareous, enhancing
It is immune, improve vascular function, play calm antipruritic and auxiliary anti-inflammatory, anti-allergy action.
The Chinese medicine composition of the present invention has its unique advantage and curative effect, and Small side effects, safer, particularly with slow
Property nettle rash can be with long period maintaining treatment, and effect is satisfactory.It is efficient by Long-term Clinical Observation, Huang Shi nettle rash sides
Up to 92%.It is long-term use of safe, and medicine source is enriched, it is cheap, both trouble can be mitigated with the symptom of reduction of patient again
The financial burden of person.
As a kind of perferred technical scheme, the described Chinese medicine composition for being used to treat nettle rash includes following parts by weight
Raw material components：40~50 parts of Os Draconis, 25~35 parts of calcined oyster shell, 25~35 parts of the capsule of weeping forsythia, 15~25 parts of divaricate saposhnikovia charcoal,
25~35 parts of charred RADIX SANGUISORBAE and 15~25 parts of madder.
As a kind of technical scheme being more highly preferred to, the described Chinese medicine composition for being used to treat nettle rash includes following weight
Measure the raw material components of part：45 parts of Os Draconis, 30 parts of calcined oyster shell, 30 parts of the capsule of weeping forsythia, 20 parts of divaricate saposhnikovia charcoal, 30 parts of charred RADIX SANGUISORBAE
With 20 parts of madder.
The present invention also discloses a kind of preparation method for being used to treat the Chinese medicine composition of nettle rash accordingly, including as follows
Step：
Step 1, immersion：Each medicine material is proportionally placed in the stainless steel cask of cleaning, according to the respective suction of medicine materical crude slice
Water rate determines amount of water, and with pure cold water soak, soak time is 20~30min；
Step 2, twice of acquisition decoction is decocted by traditional-handwork；
Step 3, machine encapsulation：The decoction progress subpackage obtained by boiling machine and packing machine to step 2 is canned, obtains
Packaged decoction.
Further, the specific steps decocted by hand in step 2 include：
A：According to the decocting medicine pot of boil medicine agent number and prepared slices of Chinese crude drugs water absorption rate selection suitable volumes；
B：By the way of decocting twice, one boils medicine is cooked by slow fire 30min after thing boils again, two decoct boiling after be cooked by slow fire again
Boil 20min；
C：Stirred 2~3 times during drug decocting, the mixing time after control medicine boils is longer than the stirring before boiling
Time.
Further, the specific steps of machine encapsulation include in step 3：
E：First the decoction endured by hand is poured into the packaging machine after cleaning, then preheats packaging machine；
F：The dosage of every bag is regulated on packaging machine, it is filling by packaging machine progress subpackage, airtight package, encapsulated
Good decoction of medicinal ingredients bag；
G：The pack for having seepage is found in F-step, the decoction in the pack of seepage is re-poured into packaging machine and carried out
Subpackage is canned, repeats F-step；
H：It is labelled outside packaged pack.
Further, cleaning procedure is carried out after pack completes, including the processing dregs of a decoction, cleaning soak explosive barrel, cleaning is decocted
Saucepan and cleaning packaging machine, cleaning standard will accomplish decoction of medicinal ingredients noresidue.
Chinese medicine composition provided by the present invention for treating nettle rash and preparation method thereof, compared with prior art, has
Beneficial effect is：
1st, it is evident in efficacy to treat nettle rash, cure rate height.
2nd, flavour of a drug number is few, and cost is low.
3rd, preparation method receives modern machines to decoct the advantages of machine encapsulates on the basis of passing on traditional-handwork and boiling medicine, and extends
The shelf-life of decoction of medicinal ingredients.
4th, pure Chinese medicinal preparation, toxic side effect is small, safe.
5th, aviod certain food without patient, reduce patient suffering's degree, increase immunity.
Embodiment
The present invention is described in further detail below by specific embodiment.
Embodiment 1：
For treating the Chinese medicine composition of nettle rash, include the raw material components of following parts by weight：30 parts of Os Draconis, 20 parts
Calcined oyster shell, 20 parts of the capsule of weeping forsythia, 10 parts of divaricate saposhnikovia charcoal, 20 parts of charred RADIX SANGUISORBAE and 10 parts of madder.
Embodiment 1 is used for the preparation method for treating the Chinese medicine composition of nettle rash, comprises the following steps：
Step 1, immersion：Each medicine material is proportionally placed in the stainless steel cask of cleaning, according to the respective suction of medicine materical crude slice
Water rate determines amount of water, adds 250 parts of water, with pure cold water soak, soak time is 20~30min；
Step 2, twice of acquisition decoction is decocted by traditional-handwork；
Step 3, machine encapsulation：The decoction progress subpackage obtained by boiling machine and packing machine to step 2 is canned, obtains
Packaged decoction.
Further, the specific steps decocted by hand in step 2 include：
A：According to the decocting medicine pot of boil medicine agent number and prepared slices of Chinese crude drugs water absorption rate selection suitable volumes；
B：By the way of decocting twice, one boils medicine is cooked by slow fire 30min after thing boils again, two decoct boiling after be cooked by slow fire again
Boil 20min；
C：Stirred 3 times during drug decocting, control medicine boil after mixing time when being longer than the stirring before boiling
Between.
Further, the specific steps of machine encapsulation include in step 3：
E：First the decoction endured by hand is poured into the packaging machine after cleaning, then preheats packaging machine；
F：The dosage of every bag is regulated on packaging machine, it is filling by packaging machine progress subpackage, airtight package, encapsulated
Good decoction of medicinal ingredients bag；
G：The pack for having seepage is found in F-step, the decoction in the pack of seepage is re-poured into packaging machine and carried out
Subpackage is canned, repeats F-step；
H：It is labelled outside packaged pack.
Embodiment 2：
For treating the Chinese medicine composition of nettle rash, include the raw material components of following parts by weight：60 parts of Os Draconis, 40 parts
Calcined oyster shell, 40 parts of the capsule of weeping forsythia, 30 parts of divaricate saposhnikovia charcoal, 40 parts of charred RADIX SANGUISORBAE and 30 parts of madder.
Embodiment 2 is used for the preparation method for treating the Chinese medicine composition of nettle rash, comprises the following steps：
Step 1, immersion：Each medicine material is proportionally placed in the stainless steel cask of cleaning, according to the respective suction of medicine materical crude slice
Water rate determines amount of water, adds 560 parts of water, with pure cold water soak, soak time is 20~30min；
Step 2, twice of acquisition decoction is decocted by traditional-handwork；
Step 3, machine encapsulation：The decoction progress subpackage obtained by boiling machine and packing machine to step 2 is canned, obtains
Packaged decoction.
Further, the specific steps decocted by hand in step 2 include：
A：According to the decocting medicine pot of boil medicine agent number and prepared slices of Chinese crude drugs water absorption rate selection suitable volumes；
B：By the way of decocting twice, one boils medicine is cooked by slow fire 30min after thing boils again, two decoct boiling after be cooked by slow fire again
Boil 20min；
C：Stirred 3 times during drug decocting, control medicine boil after mixing time when being longer than the stirring before boiling
Between.
Further, the specific steps of machine encapsulation include in step 3：
E：First the decoction endured by hand is poured into the packaging machine after cleaning, then preheats packaging machine；
F：The dosage of every bag is regulated on packaging machine, it is filling by packaging machine progress subpackage, airtight package, encapsulated
Good decoction of medicinal ingredients bag；
G：The pack for having seepage is found in F-step, the decoction in the pack of seepage is re-poured into packaging machine and carried out
Subpackage is canned, repeats F-step；
H：It is labelled outside packaged pack.
Embodiment 3：
For treating the Chinese medicine composition of nettle rash, include the raw material components of following parts by weight：40 parts of Os Draconis, 25 parts
Calcined oyster shell, 25 parts of the capsule of weeping forsythia, 15 parts of divaricate saposhnikovia charcoal, 25 parts of charred RADIX SANGUISORBAE and 15 parts of madder.
Embodiment 3 is used for the preparation method for treating the Chinese medicine composition of nettle rash, comprises the following steps：
Step 1, immersion：Each medicine material is proportionally placed in the stainless steel cask of cleaning, according to the respective suction of medicine materical crude slice
Water rate determines amount of water, adds 305 parts of water, with pure cold water soak, soak time is 20~30min；
Step 2, twice of acquisition decoction is decocted by traditional-handwork；
Step 3, machine encapsulation：The decoction progress subpackage obtained by boiling machine and packing machine to step 2 is canned, obtains
Packaged decoction.
Further, the specific steps decocted by hand in step 2 include：
A：According to the decocting medicine pot of boil medicine agent number and prepared slices of Chinese crude drugs water absorption rate selection suitable volumes；
B：By the way of decocting twice, one boils medicine is cooked by slow fire 30min after thing boils again, two decoct boiling after be cooked by slow fire again
Boil 20min；
C：Stirred 3 times during drug decocting, control medicine boil after mixing time when being longer than the stirring before boiling
Between.
Further, the specific steps of machine encapsulation include in step 3：
E：First the decoction endured by hand is poured into the packaging machine after cleaning, then preheats packaging machine；
F：The dosage of every bag is regulated on packaging machine, it is filling by packaging machine progress subpackage, airtight package, encapsulated
Good decoction of medicinal ingredients bag；
G：The pack for having seepage is found in F-step, the decoction in the pack of seepage is re-poured into packaging machine and carried out
Subpackage is canned, repeats F-step；
H：It is labelled outside packaged pack.
Embodiment 4：
For treating the Chinese medicine composition of nettle rash, include the raw material components of following parts by weight：50 parts of Os Draconis, 35 parts
Calcined oyster shell, 35 parts of the capsule of weeping forsythia, 25 parts of divaricate saposhnikovia charcoal, 35 parts of charred RADIX SANGUISORBAE and 25 parts of madder.
Embodiment 4 is used for the preparation method for treating the Chinese medicine composition of nettle rash, comprises the following steps：
Step 1, immersion：Each medicine material is proportionally placed in the stainless steel cask of cleaning, according to the respective suction of medicine materical crude slice
Water rate determines amount of water, adds 480 parts of water, with pure cold water soak, soak time is 20~30min；
Step 2, twice of acquisition decoction is decocted by traditional-handwork；
Step 3, machine encapsulation：The decoction progress subpackage obtained by boiling machine and packing machine to step 2 is canned, obtains
Packaged decoction.
Further, the specific steps decocted by hand in step 2 include：
A：According to the decocting medicine pot of boil medicine agent number and prepared slices of Chinese crude drugs water absorption rate selection suitable volumes；
B：By the way of decocting twice, one boils medicine is cooked by slow fire 30min after thing boils again, two decoct boiling after be cooked by slow fire again
Boil 20min；
C：Stirred 3 times during drug decocting, control medicine boil after mixing time when being longer than the stirring before boiling
Between.
Further, the specific steps of machine encapsulation include in step 3：
E：First the decoction endured by hand is poured into the packaging machine after cleaning, then preheats packaging machine；
F：The dosage of every bag is regulated on packaging machine, it is filling by packaging machine progress subpackage, airtight package, encapsulated
Good decoction of medicinal ingredients bag；
G：The pack for having seepage is found in F-step, the decoction in the pack of seepage is re-poured into packaging machine and carried out
Subpackage is canned, repeats F-step；
H：It is labelled outside packaged pack.
Embodiment 5：
For treating the Chinese medicine composition of nettle rash, include the raw material components of following parts by weight：45 parts of Os Draconis, 30 parts
Calcined oyster shell, 30 parts of the capsule of weeping forsythia, 20 parts of divaricate saposhnikovia charcoal, 30 parts of charred RADIX SANGUISORBAE and 20 parts of madder.
Embodiment 5 is used for the preparation method for treating the Chinese medicine composition of nettle rash, comprises the following steps：
Step 1, immersion：Each medicine material is proportionally placed in the stainless steel cask of cleaning, according to the respective suction of medicine materical crude slice
Water rate determines amount of water, adds 405 parts of water, with pure cold water soak, soak time is 20~30min；
Step 2, twice of acquisition decoction is decocted by traditional-handwork；
Step 3, machine encapsulation：The decoction progress subpackage obtained by boiling machine and packing machine to step 2 is canned, obtains
Packaged decoction.
Further, the specific steps decocted by hand in step 2 include：
A：According to the decocting medicine pot of boil medicine agent number and prepared slices of Chinese crude drugs water absorption rate selection suitable volumes；
B：By the way of decocting twice, one boils medicine is cooked by slow fire 30min after thing boils again, two decoct boiling after be cooked by slow fire again
Boil 20min；
C：Stirred 3 times during drug decocting, control medicine boil after mixing time when being longer than the stirring before boiling
Between.
Further, the specific steps of machine encapsulation include in step 3：
E：First the decoction endured by hand is poured into the packaging machine after cleaning, then preheats packaging machine；
F：The dosage of every bag is regulated on packaging machine, it is filling by packaging machine progress subpackage, airtight package, encapsulated
Good decoction of medicinal ingredients bag；
G：The pack for having seepage is found in F-step, the decoction in the pack of seepage is re-poured into packaging machine and carried out
Subpackage is canned, repeats F-step；
H：It is labelled outside packaged pack.
Embodiment 6：Animal acute toxicity test or long term toxicity test are carried out to important composition of the present invention
1st, for treating the Chinese medicine composition animal acute toxicity test of nettle rash：
Medicine：The Chinese medicine composition for being used to treat nettle rash that the embodiment of the present invention 5 obtains.
Acute toxicity：20 grams of mouse 30 are selected, by 7.5 g kg body weight dose gastric infusions once, Continuous Observation 3 days
Mouse does not occur death.Subacute toxicity test has also been done in this experiment.As a result show：For treating the Chinese medicine composition of nettle rash
After being administered by above-mentioned dosage, every Index for examination and histopathologic slide are showed no any obvious exception.
2nd, for treating the Chinese medicine composition long-term toxicity test for animals of nettle rash：
Test objective：Observation rat continuous gavage is given caused by the Chinese medicine composition 3 months for treating nettle rash
Toxic reaction, to determine the security of clinical application.
Trial drug：The Chinese medicine composition for being used to treat nettle rash that the embodiment of the present invention 5 obtains.
Experimental animal：Wister kind rats, male and female half and half：Male average weight is 95.3 ± 10.4g, female average weight
For 106.1 ± 11.22g.
Test method：Experimental animal is randomly divided into three groups：Control group；The high agent of Chinese medicine composition for treating nettle rash
Measure 9.0g/kg；Low dosage 3.0g/kg groups, every group 20, male and female half and half, according to dosage gastric infusion daily；Control group, which is given etc., to be held
Amount drinking water, continuous 12 weeks.
Animal general state is observed during administration, is weighed weekly once, penta bar of ratio is injected intraperitoneally in the next day each group animal that is discontinued
Appropriate sodium 30mg/kg anesthesia, blood indices are determined in abdominal aortic blood；Separate serum and carry out Liver and kidney function inspection, take out
And rat main organs of weighing, organ coefficient, while pathology etc. under naked eyes and mirror is carried out to it and is checked according to the weight, remaining half
Number animal, which is discontinued, continues raising two weeks, observation convalescence change.
Result of the test：(1) general state：For treating two agent of Chinese medicine composition 9.0g/kg, 3.0g/kg of nettle rash
The activity during administration of amount group rat is normal.Food-intake, drinking-water, defecation Non Apparent Abnormality, no death.(2) body weight：For treating
During two dosage group rat administrations of Chinese medicine composition of nettle rash and convalescence body weight increase changes with control group without obvious poor
It is different.(3) hematological examination：After two dosage groups of Chinese medicine composition for treating nettle rash are administered 12 weeks, indices are surveyed
In normal range (NR), without significant difference compared with control group.(4) Serum bichemisbry inspection：For treating the Chinese medicine of nettle rash
Two dosage groups of composition are after successive administration 12 weeks, and every biochemical index is in normal range (NR), the nothing compared with control group
Notable difference.(5) 1. histological observation visually observes：For treating two dosage groups of Chinese medicine composition and control group of nettle rash
Rat is autopsied after each administration time limit terminates, and visually observes and histotomy is observed, have no that obvious pathology change
Become.
Conclusion (of pressure testing)：After high and low two dosage of Chinese medicine composition for treating nettle rash was to rat oral gavage 12 weeks, not
See animal appearance, body weight increase；The toxicity change of hematology, Serum bichemisbry and main organs, illustrate to be used to treat nettle rash
Chinese medicine composition in dosage used and administration time without overt toxicity act on.
Embodiment 7：The therapeutic effect NULL and efficacy analysis of Chinese medicine composition of the present invention
1st, research method
1.1 Disease Diagnosis Standard
With reference to skin cypridology branch of Chinese Medical Association《Nettle rash practice guidelines》The diagnosis of (2007 editions) chronic urticaria.
1.2 case inclusive criterias
1. meet chronic urticaria case of clarifying a diagnosis (symptom daily or almost daily breaking-out, continue 6 weeks or 6 weeks with
Upper person), the first day sees wheal or dermographism is positive；2. receive the case of traditional Chinese medicine composition for treating of the present invention；3. there is communication
Mode, can be with the case of follow-up.
1.3 case exclusion standards
During treatment, using antihistamine, glucocorticoid, immunomodulator or related drugs or receive other forms and enter
The case of row treatment.
1.4 treatment method
With Traditional Chinese medicine composition formula provided by the invention, provided according to conditions from the embodiment of the present invention 1~5
Chinese medicine composition.Decocting liquid 200mL, morning and evening sub-service, children are cut down according to the circumstance.It is not required to especially aviod certain food during treatment, rule of life, carries out necessary
Constitution take exercise.Other medicines and (or) treatment method are disabled, elution is followed by treated for one week.Each patient is controlled during treatment
Before treatment, treatment 14d, 28d, 60d symptom integral recorded.Follow up time and mode：The course for the treatment of is carried out after terminating June
Follow-up.Interview is carried out to patient and (or) its family members by way of further consultation and (or) communication contact, and available data is carried out
Correct and perfect.
1.5 parameters for observation on effect
Using 4 grades of point systems：1. itch：0 point is nothing, 1 point for it is slight, do not influence to sleep, 2 points be moderate, influence sleep,
It can still endure, 3 points are serious, influence sleep, it is impossible to are endured, normal life is interfered.2. wheal number：0 point is nothing；1 point
For 1~10,2 points are 10~20, and 3 points are more than 20.3. wheal diameter is counted respectively by 0, ＜ 1,1~2.5 and ＞ 2.5cm
0,1,2 and 3 point.4. continuing duration of seizure every time presses 0h, ＜ 4h, 4~12h, ＞ 12h count 0,1,2,3 point respectively.5. wheal one week
Interior average daily frequency, 0 point is without wheal；1 point is that wheal occurs 1 time daily；2 points are that wheal occurs 2~3 times daily；3
It is divided into wheal and occurs ＞ daily 3 times.
1.6 the standard of curative effect evaluation
4 grades of efficacy evaluations are carried out according to therapeutic index rate of descent：1. fully recovering, therapeutic index reduces by more than 90%；2. it is effective,
Therapeutic index reduces by 61%~89%；3. effectively, therapeutic index reduces by 20%~60%；4. invalid, therapeutic index reduces deficiency
20% or continue to aggravate.Recovery from illness and effective case are included in effective case, and calculate effective percentage.Recurrence rate is with efficient reduction
Meter.[symptom integral × 100% before therapeutic index=(symptom integral after symptom integral-treatment before treatment)/treatment]
1.7 data processings and statistical analysis
Statistical analysis is carried out using SPSS13.0 statistical packages, pairing is respectively adopted according to test objective and data type
T is examined, χ2Examine etc..Inspection level α=0.05 or α=0.01.It the results are shown in Table 1, table 2.
Before the treatment of table 1, treat 14d, 28d and 60d symptom score integration change situation
| Group | n | Before treatment | Treat 14d | Treat 28d | Treat 60d |
| Itch degree | 100 | 2.36±0.57 | 2.01±0.9 | 0.83±0.89 | 0.38±0.11 |
| Wheal number | 100 | 2.26±1.03 | 2.07±0.65 | 1.02±0.79 | 0.23±0.73 |
| Wheal diameter | 100 | 2.37±0.93 | 1.85±0.73 | 0.97±1.02 | 0.31±0.98 |
| Duration | 100 | 2.18±0.81 | 1.68±0.72 | 1.13±0.68 | 0.18±0.91 |
| Attack times | 100 | 1.99±0.79 | 1.35±0.56 | 0.95±0.71 | 0.2±0.52 |
| Integration is total | 100 | 12.43±2.42 | 9.98±0.78 | 5.14±0.62 | 1.36±0.50 |
Before the treatment of table 2, treat 14d, 28d and 60d curative effect statistics [n (%)]
| The course for the treatment of | n | Recovery from illness | It is effective | Effectively | It is invalid | It is efficient |
| Treat 14d | 100 | 0 | 9 | 35 | 56 | 9% |
| Treat 28d | 100 | 11 | 39 | 32 | 18 | 49% |
| Treat 60d | 100 | 78 | 14 | 5 | 3 | 92% |
| Follow-up after June | 100 | 76 | 13 | 8 | 4 | 89% |
2nd, general curative effect analysis and assessment
Status of patient before treatment：Total number of cases 100, wherein man 47, female 53, age distribution 5~75 years old, average age
For 39.4 years old.Medical history is most short 51 days, most long 3 months 7 years, average medical history 27.56 months.Wherein 96 patients once received to control
Treat, the clear and definite antihistamine drug treatment history of 91 patients, 31 patients clearly received glucocorticoid treatment, and 85 patients are clear and definite
Received medicine of more than two kinds or method treatment.
Symptom integral changes after treatment：After treating 2 weeks, integration, which declines, changes unobvious (P ＞ 0.05), 2 weeks after treatment, 4
All symptom total mark drop-out value difference is statistically significant (P ＜ 0.01).Symptom total mark drop-out value after 4 weeks, 60 days after treatment
Difference is statistically significant (P ＜ 0.01).Follow-up changes no statistical significance (P ＞ 0.05) with being integrated after treating 2 months after half a year.
Situation after treatment：Efficient change of day part is consistent substantially through statistics with integration decline situation.The course for the treatment of and curative effect
As shown in table 2, after treating 2 months, fully recover 78, total effective rate 92%.3 are dropped by the wayside, wherein 2 are included in effective case, 1
Ineffective Cases are included in, has 1 and is removed, be included in Ineffective Cases.Follow-up after half a year, descender 3, meter are integrated in effective case
Enter recurrent cases, recurrence rate 3%.
Adverse reaction：Toxic side effect is had no in therapeutic process, only 5 constipation occur, and 3 have abdominal distension sense, advise it
After being appropriately adjusted to diet and habits and customs, symptom is voluntarily alleviated, and does not influence to continue to control malignant boil.
The traditional Chinese medicine composition for treating chronic urticaria of the present invention is can be seen that from result above, curative effect does not show in 2 weeks,
Without healing case, curative effect substantially rises after effective percentage only 9%, 4 weeks, and effective percentage reaches 49%, and after treating 2 months, curative effect reaches
To 92%.It can be seen that the treatment action of Chinese medicine is slower, but curative effect is progressively adding up, compared with relevant similar data, after treating 4 weeks,
Effective percentage is less than Loratadine, but effective percentage is better than Loratadine after 2 months, it is seen that treatment by Chinese herbs chronic urticaria will have enough
Its best efficiency of duration competence exertion.And for recurrence rate, there is presently no corresponding comparable data is seen, need further from now on
Research.There are 2 integrations to drop below criterion of cure in 78 recovery from illness cases in this research, it is seen that Chinese traditional treatment chronic urticaria is answered
Hair rate is relatively low.
3rd, herein below is several model cases in the clinical practice of traditional Chinese medicine composition for treating nettle rash of the present invention, is now plucked
Record is as follows：
Case 1
Mr. Wang, male, 29 years old, on June 3rd, 2015 was medical.There is wheal 2 years in whole body, and multi-party treatment curative effect is undesirable.To examine
When trunk, four limbs have generalized erythema, the overlying scales of skin that peel off, itch, tongue is red, yellow tongue fur, veins string.Diagnosis：Nettle rash.Dialectical is that interior heat is vehement
The sign of Sheng, control preferably it is clearing heat and detoxicating, cool blood moves back spot.It is used to treating the Chinese medicine composition of nettle rash using the present invention, one portion per day, often
Secondary 250ml, after meal half an hour warmly take.With 90 days for a course for the treatment of, fash all disappears after a course for the treatment of.Follow-up is so far without multiple
Hair.
Case 2：
Zhao, man, 26 years old.April 20 in 2014 is medical.There is wheal more than 1 month in whole body.Patient's readme ate sea before 1 month
Burst wheal in the whole body after fresh, acute pruritus, night is more so.Once it is effective with treatments such as antihistamine, vitamin C, calcium agent, but be discontinued
Easily recurrence.Symptom is often in body heat perspiration postemphasis.Existing whole body is dispersed in wheal, and meromixis is in blocks, and color is scarlet, and scratch is obvious, sleeps
Sleep poor, dry, red tongue body, yellow and greasy fur, wiry and rolling pulse.Diagnosis：Nettle rash.It is dialectical to attack table for ailment said due to cold or exposure, inside have damp and hot.Control suitable important city
Calm the nerves antipruritic, blood-stanching and blood-cooling.It is used for the Chinese medicine composition for treating nettle rash, one portion per day, each 250ml, meal using the present invention
Half an hour after warmly takes.With 90 days for a course for the treatment of, take the rash hair time after 1/3 course for the treatment of and delay, symptom mitigation, but four limbs,
Sent out when at scalp still, body heat is irritated, itches very, thirsty, does during stool.Advise deactivation Western medicine.After taking 1/3 course for the treatment of again, attack times
Reduce, mood is taken a turn for the better, and stool is mixed well.1/3 course for the treatment of after treatment is taken again.Follow-up is not recurred for 3 months.
Case 3：
Mr. Wang, female, 41 years old, first visit on December 5 in 2016, patient told unknown cause skin scabies 1 year, skin after scratching over 3 years
There is streak red wheal in skin, and oral a variety of antihistamine drugs can not be eradicated, when and temporary relief of symptoms.Symptoms include patient skin
Strip or the light red slight water relief of symptoms of different shape wheal color after touch or after drawing.Symptoms include patient skin touch after or draw after bar
Shape or different shape wheal color are light red, and Mild edema itch is abnormal, and menstruation is delayed, and the few color of amount is dark, and arteries and veins is thin, diagnosis：Nettle rash.Distinguish
Demonstrate,prove as deficiency of Yin wind-dryness.Control suitable transquilization with heavy material, nourishing Yin and falling fire.It is used for the Chinese medicine composition for treating nettle rash using the present invention, daily
It is one, each 250ml, after meal half an hour warmly take.With 90 days for a course for the treatment of, all diseases are disappeared after a course for the treatment of.Follow-up is so far
Without recurrence.
Case 4：
Week certain, female, 30 years old, on March 1st, 2017 was medical, before 1 year winter play ball after sweating catch a cold, cold, fever cough and asthma frequency
Make, the puffiness of the eyes, face four limbs are itched, and are taken Chinese and Western medicine to daybreak and are alleviated, and it is to see wheal sample skin that it is all over that cold water is contacted after avenging this winter
Rash protrusion rash color is red, and itching, with seeing that chilly body is cold, difficult urination, pale tongue with thin fur is white, and floating pulse is counted accurately, diagnosis：Nettle rash.It is dialectical
For chill visitor's lung.Control antipruritic, harmonizing yingfen and weifen of preferably calming the nerves.It is used to treating the Chinese medicine composition of nettle rash using the present invention, daily one
Agent, each 250ml, after meal half an hour warmly take.With 90 days for a course for the treatment of, all diseases are disappeared after a course for the treatment of.Follow-up so far without
Recurrence.
The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention, for the skill of this area
For art personnel, the present invention can have various modifications and variations.Within the spirit and principles of the invention, that is made any repaiies
Change, equivalent substitution, improvement etc., should be included in the scope of the protection.
Claims (7)
1. a kind of Chinese medicine composition for being used to treat nettle rash, it is characterised in that include the raw material components of following parts by weight：30~
60 parts of Os Draconis, 20~40 parts of calcined oyster shell, 20~40 parts of the capsule of weeping forsythia, 10~30 parts of divaricate saposhnikovia charcoal, 20~40 parts of garden burnet
Charcoal and 10~30 parts of madder.
2. the Chinese medicine composition according to claim 1 for being used to treat nettle rash, it is characterised in that including following parts by weight
Raw material components：40~50 parts of Os Draconis, 25~35 parts of calcined oyster shell, 25~35 parts of the capsule of weeping forsythia, 15~25 parts of divaricate saposhnikovia charcoal,
25~35 parts of charred RADIX SANGUISORBAE and 15~25 parts of madder.
3. the Chinese medicine composition according to claim 1 for being used to treat nettle rash, it is characterised in that including following parts by weight
Raw material components：45 parts of Os Draconis, 30 parts of calcined oyster shell, 30 parts of the capsule of weeping forsythia, 20 parts of divaricate saposhnikovia charcoal, 30 parts of charred RADIX SANGUISORBAE and 20
The madder of part.
4. the preparation method for being used to treat the Chinese medicine composition of nettle rash described in any one of claims 1 to 3, its feature exist
In comprising the following steps：
Step 1, immersion：Each medicine material is proportionally placed in the stainless steel cask of cleaning, according to the respective water absorption rate of medicine materical crude slice
Amount of water is determined, with pure cold water soak, soak time is 20~30min；
Step 2, twice of acquisition decoction is decocted by traditional-handwork；
Step 3, machine encapsulation：The decoction progress subpackage obtained by boiling machine and packing machine to step 2 is canned, is encapsulated
Good decoction.
5. the preparation method according to claim 4 for being used to treat the Chinese medicine composition of nettle rash, it is characterised in that step
The specific steps decocted by hand in two include：
A：According to the decocting medicine pot of boil medicine agent number and prepared slices of Chinese crude drugs water absorption rate selection suitable volumes；
B：By the way of decocting twice, one boils medicine is cooked by slow fire 30min after thing boils again, two decoct boiling after be cooked by slow fire again
20min；
C：Stirred 2~3 times during drug decocting, control medicine boil after mixing time when being longer than the stirring before boiling
Between.
6. the preparation method according to claim 4 for being used to treat the Chinese medicine composition of nettle rash, it is characterised in that step
The specific steps of machine encapsulation include in three：
E：First the decoction endured by hand is poured into the packaging machine after cleaning, then preheats packaging machine；
F：The dosage of every bag is regulated on packaging machine, it is filling by packaging machine progress subpackage, airtight package, obtain packaged
Decoction of medicinal ingredients bag；
G：The pack for having seepage is found in F-step, the decoction in the pack of seepage is re-poured into packaging machine and carries out subpackage
It is canned, repeat F-step；
H：It is labelled outside packaged pack.
7. the preparation method according to claim 4 for being used to treat the Chinese medicine composition of nettle rash, it is characterised in that pack
Cleaning procedure, including the processing dregs of a decoction, cleaning leaching explosive barrel, cleaning decoction pot and cleaning packaging machine are carried out after completing.
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