CN107412360A - Phlebitis herbal paste and preparation method and application - Google Patents
Phlebitis herbal paste and preparation method and application Download PDFInfo
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- CN107412360A CN107412360A CN201710792209.XA CN201710792209A CN107412360A CN 107412360 A CN107412360 A CN 107412360A CN 201710792209 A CN201710792209 A CN 201710792209A CN 107412360 A CN107412360 A CN 107412360A
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Abstract
The present invention relates to a kind of phlebitis herbal paste and preparation method and application, the raw material components of phlebitis herbal paste by weight, including：The raw parts by weight of the Radix Astragali 205~215, the parts by weight of Radix Angelicae Sinensis 100~110, the parts by weight of Ligusticum wallichii 80~90, the parts by weight of the red sage root 135~145, the parts by weight of the radix paeoniae rubrathe 100~110, the parts by weight of giant knotweed 135~145, the parts by weight of earthworm 60~65, the parts by weight of rhizoma atractylodis 104~106 and the parts by weight of pseudo-ginseng 40~44.The present invention is used as raw material by medicinal materials such as the selected raw Radix Astragali, Radix Angelicae Sinensis, Ligusticum wallichii and pseudo-ginseng and extracts active component, and the phlebitis herbal paste being refining to obtain has the effect of preventing and/or treating phlebitis, evident in efficacy, and safe without toxic side effect；Easy to use, cost is relatively low, has good commercial promise.
Description
Technical field
The present invention relates to field of medicine preparing technology, and in particular to a kind of phlebitis herbal paste and preparation method and application.
Background technology
Thrombophlebitis abbreviation phlebitis, refers to vein blood vessel inflammation, different according to diseased region, and phlebitis can be divided into
Superficial phlebitis and deep phlebitis.Superficial phlebitis patient, sick lower limb vein are red and swollen, pain, aggravate during walking, accessible pain sex cords shape is hard
Bar or beading sample tubercle；Deep phlebitis patient, morbidity is unexpected, and suffering limb is in pitting swelling, and skin is in kermesinus, has extensive
Vein exerts or varicose and telangiectasis；There is dystrophia and sexually revised in later stage, with stasis of blood product property dermatitis, pigmentation
Or exulceratio simplex, stock, shin Zhou Jing compared with strong thick more than the 1cm of limb, during walking swelling and pain aggravate, mitigate after reposing, phlebography is visible
Suffering limb Deep venou hemadostewnosis or blocking.Migrans thrombus superficial phlebitis, refer to that superficial vein inflammation happening part is indefinite, this plays that
Lie prostrate, be a kind of specific type in human body superficial phlebitis for recurrent exerbation.Chest and abdomen wall superficial thrombophlebitis, refers to the wall of the chest,
There is venous thronbosis in breast, two costal margins and upper abdomen, and have a kind of common disease of inflammatory pathological change simultaneously, also known as
Monder diseases.The medicine of existing treatment phlebitis, most initial stages are effective, but can not be really achieved the purpose for the treatment of phlebitis,
And treatment cycle is long, curative effect is slow, drug dose is big, and medical expense is high.Therefore, it is existing treatment phlebitis Chinese and western drugses not
The needs of many patients can be met, it is also necessary to study medicine that is new, can safely and effectively treating phlebitis.
The content of the invention
For in the prior art the defects of, present invention aims at provide a kind of phlebitis herbal paste and preparation method thereof with should
With, as raw material, to extract active component by medicinal materials such as the selected raw Radix Astragali, Radix Angelicae Sinensis, Ligusticum wallichii and pseudo-ginseng and be refining to obtain vein
Scorching herbal paste, there is the effect of preventing and/or treating phlebitis, safe without toxic side effect；Easy to use, cost is relatively low, has very
Good commercial promise.
To achieve the above object, technical scheme provided by the invention is：
In a first aspect, the invention provides a kind of phlebitis herbal paste, the raw material components of phlebitis herbal paste by weight, wrap
Include：The raw parts by weight of the Radix Astragali 205~215, the parts by weight of Radix Angelicae Sinensis 100~110, the parts by weight of Ligusticum wallichii 80~90, the weight of the red sage root 135~145
Part, the parts by weight of the radix paeoniae rubrathe 100~110, the parts by weight of giant knotweed 135~145, the parts by weight of earthworm 60~65, the parts by weight of rhizoma atractylodis 104~106
With the parts by weight of pseudo-ginseng 40~44.
In the further embodiment of the present invention, the raw material components of phlebitis herbal paste also include：The weight of golden cypress 102~108
Measure part, the parts by weight of honeysuckle 275~285 and the parts by weight of raw cape jasmine 82~86.
The present invention further embodiment in, the raw material components of phlebitis herbal paste by weight, including：The raw Radix Astragali
210 parts by weight, the parts by weight of Radix Angelicae Sinensis 105, the parts by weight of Ligusticum wallichii 84, the parts by weight of the red sage root 140, the parts by weight of the radix paeoniae rubrathe 105, the weight of giant knotweed 140
Part, the parts by weight of earthworm 63, the parts by weight of rhizoma atractylodis 105, the parts by weight of pseudo-ginseng 42, the parts by weight of golden cypress 105, the parts by weight of honeysuckle 280 and life
The parts by weight of cape jasmine 84.It should be noted that method of the we using " treating a disease by looking into both its root cause and symptoms ", the product of bitter cold are not had in medication, it is otherwise evil
Do not dispel, just hindered, sering is cool to hold back occlusion.It is our main ingredient that the raw Radix Astragali, the red sage root are used in phlebitis herbal paste, and it is taken using the raw Radix Astragali
Piao is brave, the property walked without keeping, invigorating qi for consolidating superficies water with the power of walk help blood detumescence, " by the extravesated blood of the five internal organs, there is QI invigorating, Li Yin gas " it
Work(, Li Shui, stagnation resolvation, unbiased are cold, the disadvantage of partial heat, be " blood medicine in gas " to have obvious inducing diuresis for removing edema effect；The red sage root simply, blood-nourishing
Promoting blood circulation, work(with four things, for this disease can dissolving stasis blood and raw new blood, make qi and blood unobstructed, promoting circulation of blood of invigorating blood circulation, the water that makes to gather by the stasis of blood is wet to disappear
Dissipate, with raw stilbene then tonification and purgation in combination, qi and blood is taken into account.For assistant with " gas medicine in blood " Ligusticum wallichii, pungent-warm perfume (or spice) is dry, walks without keeping, can go it is scattered, again
Enter blood system, promoting blood circulation effect is extensive, the suitable various illnesss of stagnation of blood stasis.Chinese herbaceous peony blood-nourishing relieving spasm to stop pain and logical blood-arthralgia, with cassia twig
Share, adjust in Ying Wei and table；The product that Fang Zhongyong QI invigorating is activated yang help the medicine with activating blood and eliminatng dampness with strengthening vital QI to eliminate pathogenic factors.It is equipped with Radix Angelicae Sinensis,《This
Through》Cloud：Radix Angelicae Sinensis, sweet, temperature, benefiting blood and regulating blood circulation.Insects blood-activating drug is applied in blood-activating drug, mixes danggui buxue decoction, promoting blood circulation, benefit
Gas blood-nourishing is without hindering healthy tendency.Then only with product promoting blood circulation and removing blood stasis, then strength is insufficient, heals the in love insect medicine dissipating blood stasis with potent drugs of meat, ground
Dragon is longer than dredging collateral spasmolysis, dispersing blood stasis blood.Radix Angelicae Sinensis, the red sage root, pseudo-ginseng, the analgesic of Ligusticum wallichii promoting blood circulation；Golden cypress clearing heat and promoting diuresis is detoxified；Cape jasmine,
Honeysuckle clearing heat-fire detoxifies；Giant knotweed is clearing heat and detoxicating, blood stasis removing analgesic；Rhizoma atractylodis are drying damp and strengthening spleen, and compared with the bighead atractylodes rhizome, rhizoma atractylodis walk the property of table
It is stronger, and the turbid power of clearing dampization is better than the bighead atractylodes rhizome, therefore abandon the bighead atractylodes rhizome with rhizoma atractylodis.The prescription prescription is succinct, auxiliary based on Bu Qi Fu Zheng
With promoting blood circulation and removing obstruction in channels, clearing heat and detoxicating dissipating bind, number taste medicine use in conjunction, effect concentrate one's efforts it is grand, promoting blood circulation dredging collateral without hindering healthy tendency, meanwhile,
Focus on damp evil to suffer from, be aided with qi-regulating dampness elimination.
Second aspect, the invention provides the preparation method of phlebitis herbal paste, comprise the following steps：S1：Will be in addition to pseudo-ginseng
Other all raw material components be added to the water, soak preset time；S2：The mixture that immersion obtains is subjected to decoction extraction,
Collect filtrate；S3：Dissolved with water after pseudo-ginseng is crushed, be then well mixed with filtrate, obtain admixing medical solutions；S4：Medicine will be mixed
Liquid concentrates, and obtains phlebitis herbal paste.
In the further embodiment of the present invention, in S1, the quality of water is other all raw material components in addition to pseudo-ginseng
9~11 times of gross mass；The time of immersion is 11~13h.It should be noted that can be by other all originals in addition to pseudo-ginseng
Material component is added into specific bag for decocting medicinal herbs, is then put jacketed pan of boiling medicine into and is soaked.
The present invention further embodiment in, in S2, decoct extraction number be 3 times, every time decoct extraction when
Between be 1.4~1.6h, decoction and the dregs of a decoction are separated using 100 mesh sieves after decocting extraction every time；The water added every time
Quality is 9~11 times of the gross mass of other all raw material components in addition to pseudo-ginseng；Filtrate decocts extraction and obtained three times
The merging liquid of decoction.It should be noted that be preferably to decoct 3 progress of extraction point, including：One is decocted, and S1 has been soaked to obtain
Mixture decoct 1.4~1.6h in jacketed pan heating of boiling medicine, then with 100 mesh screens, collect the first filtrate and the respectively
One filter residue；The water of the gross mass of 9~11 times of other all raw material components in addition to pseudo-ginseng is added into first dregs of a decoction, carries out two
Decoct, decoct 1.4~1.6h of extraction, with 100 mesh screens, collect the second filtrate and the second filter residue respectively；Add into second dregs of a decoction
Enter the water of the gross mass of 9~11 times of other all raw material components in addition to pseudo-ginseng, carry out three and decoct, decoct 1.4~1.6h of extraction, use
100 mesh screens, the 3rd filtrate is collected, merge the first filtrate, the second filtrate and the 3rd filtrate, obtain merging filtrate.
In the further embodiment of the present invention, in S3, the temperature of water is 50~60 DEG C, and the quality of water is the matter of pseudo-ginseng
1~2 times of amount.
In the further embodiment of the present invention, in S4, concentration includes once concentration and secondary concentration：By admixing medical solutions
Once concentrated, obtain concentrated extract；Then concentrated extract is subjected to secondary concentration；Wherein, the temperature once concentrated is 60
~70 DEG C, the temperature of secondary concentration is 50~60 DEG C.
In the further embodiment of the present invention, in S4, once it is concentrated in outer circulation vacuum concentration boiling machine and carries out,
Secondary concentration is carried out in constant temperature electric-heating container.Boiled medicine it should be noted that pouring admixing medical solutions into outer circulation and being concentrated in vacuo
In machine, decoction concentration is carried out under 60 DEG C~70 DEG C constant temperatures, during the state to be concentrated to clear cream (concentrated extract), general while hot
Concentrated extract filters out, and moves on in constant temperature electric-heating container and continues to concentrate, is stirred continuously, when ointment is concentrated into " extension flag " or " drips
Cream, as phlebitis herbal paste are received during beading ".
The third aspect, it is of the invention also to protect phlebitis herbal paste answering in the medicine for preparing prevention and/or treatment phlebitis
With.
It should be noted that the application method for the phlebitis herbal paste that the present invention is prepared is preferably：Take with warm water,
25g (1 bag), 2 times a day；Edible time can be adjusted according to the state of an illness.
Phlebitis herbal paste prepared by the above method can be further prepared into pharmaceutically acceptable formulation as needed.This
Outside, protection scope of the present invention is fallen within as medicine made of active component using above-mentioned phlebitis herbal paste.By by above-mentioned vein
Scorching herbal paste, prepared after directly preparing or adding pharmaceutically acceptable auxiliary material, can be made into any pharmaceutically acceptable formulation.
Technical scheme provided by the invention, there is following beneficial effect：(1) phlebitis herbal paste provided by the invention, choosing
It is the Chinese medicinal material containing active skull cap components, prescription proportioning science, does not add any Western medicine hormonal components, it is safe and non-toxic
Side effect；(2) phlebitis herbal paste provided by the invention has the function such as excellent prevention and/or treatment phlebitis, safe and non-toxic
Side effect；Easy to use, cost is relatively low, has good commercial promise；(3) preparation method provided by the invention is used, can
While each bulk drug active component is retained to greatest extent, the active ingredient in each raw medicinal material can be fully discharged
Come, so that the herbal paste being finally prepared not only has good drug effect, and be easy to absorb, and then be rapidly achieved treatment vein
Scorching purpose.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obtain substantially, or recognized by the practice of the present invention.
Embodiment
Below in conjunction with the embodiment of the present invention, technical scheme is clearly and completely described.Implement below
Example is only used for clearly illustrating technical scheme, therefore be intended only as example, and can not limit this hair with this
Bright protection domain.
Experimental method in following embodiments, it is conventional method unless otherwise specified.Examination used in following embodiments
Material is tested, is to be commercially available from regular shops unless otherwise specified.Quantitative test in following examples, is respectively provided with three
Secondary to repeat to test, data are to repeat the average value or mean+SD of experiment three times.
The life Radix Astragali used, Radix Angelicae Sinensis, Ligusticum wallichii, the red sage root, the radix paeoniae rubrathe, giant knotweed, earthworm, rhizoma atractylodis, pseudo-ginseng, Huang in following embodiments
Cypress, honeysuckle and raw cape jasmine meet the pertinent regulations under each medicinal material item of text of Chinese Pharmacopoeia (version in 2015).Before feeding intake,
By identification, ingredients material object is consistent with title, and quality meets standard.
The present invention provides a kind of phlebitis herbal paste, the raw material components of phlebitis herbal paste by weight, including：The raw Radix Astragali
205~215 parts by weight, the parts by weight of Radix Angelicae Sinensis 100~110, the parts by weight of Ligusticum wallichii 80~90, the parts by weight of the red sage root 135~145, the radix paeoniae rubrathe 100
~110 parts by weight, the parts by weight of giant knotweed 135~145, the parts by weight of earthworm 60~65, the parts by weight of rhizoma atractylodis 104~106 and pseudo-ginseng 40~
44 parts by weight.
Preferably, raw material components also include：The parts by weight of golden cypress 102~108, the parts by weight of honeysuckle 275~285 and raw cape jasmine
82~86 parts by weight.
In addition, present invention also offers the preparation method of above-mentioned phlebitis herbal paste, comprise the following steps：
S1：Other all raw material components in addition to pseudo-ginseng are added to the water, soak 11~13h；Wherein, the quality of water is
9~11 times of the gross mass of other all raw material components in addition to pseudo-ginseng；
S2：The mixture that immersion obtains is subjected to decoction extraction, the number for decocting extraction is 3 times, is specifically included：One decocts,
The mixture that S1 has soaked to obtain is decocted into 1.4~1.6h in jacketed pan heating of boiling medicine, then with 100 mesh screens, received respectively
Collect the first filtrate and the first filter residue；Total matter of 9~11 times of other all raw material components in addition to pseudo-ginseng is added into first dregs of a decoction
The water of amount, carry out two and decoct, decoct 1.4~1.6h of extraction, with 100 mesh screens, collect the second filtrate and the second filter residue respectively；It is past
The water of the gross mass of 9~11 times of other all raw material components in addition to pseudo-ginseng is added in second dregs of a decoction, three is carried out and decocts, decoct extraction
1.4~1.6h, with 100 mesh screens, the 3rd filtrate is collected, merges the first filtrate, the second filtrate and the 3rd filtrate, is merged
Filtrate；
S3：Dissolved with 50~60 DEG C of water after pseudo-ginseng is crushed, be then well mixed with merging filtrate, obtain mixing medicine
Liquid；Wherein, the quality of water is 1~2 times of the quality of pseudo-ginseng；
S4：Admixing medical solutions are concentrated：Admixing medical solutions are once concentrated in outer circulating vacuum concentrates boiling machine, once
The temperature of concentration is 60~70 DEG C, obtains concentrated extract；Then concentrated extract is carried out in constant temperature electric-heating container secondary dense
Contracting, the temperature of secondary concentration is 50~60 DEG C, receives cream when concentrated extract is concentrated into " beading of dripping ", obtains phlebitis herbal paste.
Phlebitis herbal paste provided by the invention and preparation method thereof is described further with reference to embodiment.
Embodiment one
The present embodiment provides a kind of phlebitis herbal paste, raw material components by weight, including：The raw parts by weight of the Radix Astragali 210, when
Return 105 parts by weight, the parts by weight of Ligusticum wallichii 84, the parts by weight of the red sage root 140, the parts by weight of the radix paeoniae rubrathe 105, the parts by weight of giant knotweed 140, the weight of earthworm 63
Part, the parts by weight of rhizoma atractylodis 105 and the parts by weight of pseudo-ginseng 42.
By above-mentioned raw material, using the preparation method of phlebitis herbal paste provided by the invention, phlebitis herbal paste is prepared：
S1：Other all raw material components in addition to pseudo-ginseng are added to the water, soak 12h；Wherein, the quality of water is to remove three
10 times of the gross mass of other all raw material components outside seven；
S2：The mixture that immersion obtains is subjected to decoction extraction, the number for decocting extraction is 3 times, is specifically included：One decocts,
The mixture that S1 has soaked to obtain is decocted into 1.5h in jacketed pan heating of boiling medicine, then with 100 mesh screens, collects first respectively
Filtrate and the first filter residue；The water of the gross mass of 10 times of other all raw material components in addition to pseudo-ginseng is added into first dregs of a decoction, is entered
Row two is decocted, and is decocted extraction 1.5h, with 100 mesh screens, is collected the second filtrate and the second filter residue respectively；Added into second dregs of a decoction
The water of the gross mass of 10 times of other all raw material components in addition to pseudo-ginseng, carry out three and decoct, extraction 1.5h is decocted, with 100 mesh sieve mistakes
Filter, the 3rd filtrate is collected, merge the first filtrate, the second filtrate and the 3rd filtrate, obtain merging filtrate；
S3：Dissolved after pseudo-ginseng is crushed with 55 DEG C of water, be then well mixed with merging filtrate, obtain admixing medical solutions；Its
In, the quality of water is 1.5 times of the quality of pseudo-ginseng；
S4：Admixing medical solutions are concentrated：Admixing medical solutions are once concentrated in outer circulating vacuum concentrates boiling machine, once
The temperature of concentration is 65 DEG C, obtains concentrated extract；Then concentrated extract is subjected to secondary concentration in constant temperature electric-heating container, two
The temperature of secondary concentration is 55 DEG C, receives cream when concentrated extract is concentrated into " beading of dripping ", obtains phlebitis herbal paste.
Embodiment two
The present embodiment provides a kind of phlebitis herbal paste, raw material components by weight, including：The raw parts by weight of the Radix Astragali 205, when
Return 110 parts by weight, the parts by weight of Ligusticum wallichii 80, the parts by weight of the red sage root 145, the parts by weight of the radix paeoniae rubrathe 100, the parts by weight of giant knotweed 145, the weight of earthworm 60
Part, the parts by weight of rhizoma atractylodis 106 and the parts by weight of pseudo-ginseng 40.
By above-mentioned raw material, using the preparation method of phlebitis herbal paste provided by the invention, phlebitis herbal paste is prepared：
S1：Other all raw material components in addition to pseudo-ginseng are added to the water, soak 11h；Wherein, the quality of water is to remove three
9 times of the gross mass of other all raw material components outside seven；
S2：The mixture that immersion obtains is subjected to decoction extraction, the number for decocting extraction is 3 times, is specifically included：One decocts,
The mixture that S1 has soaked to obtain is decocted into 1.4h in jacketed pan heating of boiling medicine, then with 100 mesh screens, collects first respectively
Filtrate and the first filter residue；The water of the gross mass of 9 times of other all raw material components in addition to pseudo-ginseng is added into first dregs of a decoction, is carried out
Two decoct, and decoct extraction 1.4h, with 100 mesh screens, collect the second filtrate and the second filter residue respectively；9 are added into second dregs of a decoction
The water of the gross mass of other all raw material components times in addition to pseudo-ginseng, carry out three and decoct, decoct extraction 1.4h, with 100 mesh screens,
The 3rd filtrate is collected, merges the first filtrate, the second filtrate and the 3rd filtrate, obtains merging filtrate；
S3：Dissolved after pseudo-ginseng is crushed with 50 DEG C of water, be then well mixed with merging filtrate, obtain admixing medical solutions；Its
In, the quality of water is 1 times of the quality of pseudo-ginseng；
S4：Admixing medical solutions are concentrated：Admixing medical solutions are once concentrated in outer circulating vacuum concentrates boiling machine, once
The temperature of concentration is 60 DEG C, obtains concentrated extract；Then concentrated extract is subjected to secondary concentration in constant temperature electric-heating container, two
The temperature of secondary concentration is 50 DEG C, receives cream when concentrated extract is concentrated into " beading of dripping ", obtains phlebitis herbal paste.
Embodiment three
The present embodiment provides a kind of phlebitis herbal paste, raw material components by weight, including：The raw parts by weight of the Radix Astragali 215, when
Return 100 parts by weight, the parts by weight of Ligusticum wallichii 90, the parts by weight of the red sage root 135, the parts by weight of the radix paeoniae rubrathe 110, the parts by weight of giant knotweed 135, the weight of earthworm 65
Part, the parts by weight of rhizoma atractylodis 104 and the parts by weight of pseudo-ginseng 44.
By above-mentioned raw material, using the preparation method of phlebitis herbal paste provided by the invention, phlebitis herbal paste is prepared：
S1：Other all raw material components in addition to pseudo-ginseng are added to the water, soak 13h；Wherein, the quality of water is to remove three
11 times of the gross mass of other all raw material components outside seven；
S2：The mixture that immersion obtains is subjected to decoction extraction, the number for decocting extraction is 3 times, is specifically included：One decocts,
The mixture that S1 has soaked to obtain is decocted into 1.6h in jacketed pan heating of boiling medicine, then with 100 mesh screens, collects first respectively
Filtrate and the first filter residue；The water of the gross mass of 11 times of other all raw material components in addition to pseudo-ginseng is added into first dregs of a decoction, is entered
Row two is decocted, and is decocted extraction 1.6h, with 100 mesh screens, is collected the second filtrate and the second filter residue respectively；Added into second dregs of a decoction
The water of the gross mass of 11 times of other all raw material components in addition to pseudo-ginseng, carry out three and decoct, extraction 1.6h is decocted, with 100 mesh sieve mistakes
Filter, the 3rd filtrate is collected, merge the first filtrate, the second filtrate and the 3rd filtrate, obtain merging filtrate；
S3：Dissolved after pseudo-ginseng is crushed with 60 DEG C of water, be then well mixed with merging filtrate, obtain admixing medical solutions；Its
In, the quality of water is 2 times of the quality of pseudo-ginseng；
S4：Admixing medical solutions are concentrated：Admixing medical solutions are once concentrated in outer circulating vacuum concentrates boiling machine, once
The temperature of concentration is 70 DEG C, obtains concentrated extract；Then concentrated extract is subjected to secondary concentration in constant temperature electric-heating container, two
The temperature of secondary concentration is 60 DEG C, receives cream when concentrated extract is concentrated into " beading of dripping ", obtains phlebitis herbal paste.
Example IV
The present embodiment provides a kind of phlebitis herbal paste, raw material components by weight, including：The raw parts by weight of the Radix Astragali 210, when
Return 105 parts by weight, the parts by weight of Ligusticum wallichii 84, the parts by weight of the red sage root 140, the parts by weight of the radix paeoniae rubrathe 105, the parts by weight of giant knotweed 140, the weight of earthworm 63
Part, the parts by weight of rhizoma atractylodis 105, the parts by weight of pseudo-ginseng 42, the parts by weight of golden cypress 105, the parts by weight of honeysuckle 280 and the parts by weight of raw cape jasmine 84.
By above-mentioned raw material, using the preparation method of phlebitis herbal paste provided by the invention, phlebitis herbal paste is prepared：
S1：Other all raw material components in addition to pseudo-ginseng are added to the water, soak 12h；Wherein, the quality of water is to remove three
10 times of the gross mass of other all raw material components outside seven；
S2：The mixture that immersion obtains is subjected to decoction extraction, the number for decocting extraction is 3 times, is specifically included：One decocts,
The mixture that S1 has soaked to obtain is decocted into 1.5h in jacketed pan heating of boiling medicine, then with 100 mesh screens, collects first respectively
Filtrate and the first filter residue；The water of the gross mass of 10 times of other all raw material components in addition to pseudo-ginseng is added into first dregs of a decoction, is entered
Row two is decocted, and is decocted extraction 1.5h, with 100 mesh screens, is collected the second filtrate and the second filter residue respectively；Added into second dregs of a decoction
The water of the gross mass of 10 times of other all raw material components in addition to pseudo-ginseng, carry out three and decoct, extraction 1.5h is decocted, with 100 mesh sieve mistakes
Filter, the 3rd filtrate is collected, merge the first filtrate, the second filtrate and the 3rd filtrate, obtain merging filtrate；
S3：Dissolved after pseudo-ginseng is crushed with 55 DEG C of water, be then well mixed with merging filtrate, obtain admixing medical solutions；Its
In, the quality of water is 1.5 times of the quality of pseudo-ginseng；
S4：Admixing medical solutions are concentrated：Admixing medical solutions are once concentrated in outer circulating vacuum concentrates boiling machine, once
The temperature of concentration is 65 DEG C, obtains concentrated extract；Then concentrated extract is subjected to secondary concentration in constant temperature electric-heating container, two
The temperature of secondary concentration is 55 DEG C, receives cream when concentrated extract is concentrated into " beading of dripping ", obtains phlebitis herbal paste.
Embodiment five
The present embodiment provides a kind of phlebitis herbal paste, raw material components by weight, including：The raw parts by weight of the Radix Astragali 205, when
Return 110 parts by weight, the parts by weight of Ligusticum wallichii 80, the parts by weight of the red sage root 145, the parts by weight of the radix paeoniae rubrathe 100, the parts by weight of giant knotweed 145, the weight of earthworm 60
Part, the parts by weight of rhizoma atractylodis 106, the parts by weight of pseudo-ginseng 40, the parts by weight of golden cypress 108, the parts by weight of honeysuckle 275 and the parts by weight of raw cape jasmine 86.
By above-mentioned raw material, using the preparation method of phlebitis herbal paste provided by the invention, phlebitis herbal paste is prepared：
S1：Other all raw material components in addition to pseudo-ginseng are added to the water, soak 11h；Wherein, the quality of water is to remove three
9 times of the gross mass of other all raw material components outside seven；
S2：The mixture that immersion obtains is subjected to decoction extraction, the number for decocting extraction is 3 times, is specifically included：One decocts,
The mixture that S1 has soaked to obtain is decocted into 1.4h in jacketed pan heating of boiling medicine, then with 100 mesh screens, collects first respectively
Filtrate and the first filter residue；The water of the gross mass of 9 times of other all raw material components in addition to pseudo-ginseng is added into first dregs of a decoction, is carried out
Two decoct, and decoct extraction 1.4h, with 100 mesh screens, collect the second filtrate and the second filter residue respectively；9 are added into second dregs of a decoction
The water of the gross mass of other all raw material components times in addition to pseudo-ginseng, carry out three and decoct, decoct extraction 1.4h, with 100 mesh screens,
The 3rd filtrate is collected, merges the first filtrate, the second filtrate and the 3rd filtrate, obtains merging filtrate；
S3：Dissolved after pseudo-ginseng is crushed with 50 DEG C of water, be then well mixed with merging filtrate, obtain admixing medical solutions；Its
In, the quality of water is 1 times of the quality of pseudo-ginseng；
S4：Admixing medical solutions are concentrated：Admixing medical solutions are once concentrated in outer circulating vacuum concentrates boiling machine, once
The temperature of concentration is 60 DEG C, obtains concentrated extract；Then concentrated extract is subjected to secondary concentration in constant temperature electric-heating container, two
The temperature of secondary concentration is 50 DEG C, receives cream when concentrated extract is concentrated into " beading of dripping ", obtains phlebitis herbal paste.
Embodiment six
The present embodiment provides a kind of phlebitis herbal paste, raw material components by weight, including：The raw parts by weight of the Radix Astragali 215, when
Return 100 parts by weight, the parts by weight of Ligusticum wallichii 90, the parts by weight of the red sage root 135, the parts by weight of the radix paeoniae rubrathe 110, the parts by weight of giant knotweed 135, the weight of earthworm 65
Part, the parts by weight of rhizoma atractylodis 104, the parts by weight of pseudo-ginseng 44, the parts by weight of golden cypress 102, the parts by weight of honeysuckle 285 and the parts by weight of raw cape jasmine 82.
By above-mentioned raw material, using the preparation method of phlebitis herbal paste provided by the invention, phlebitis herbal paste is prepared：
S1：Other all raw material components in addition to pseudo-ginseng are added to the water, soak 13h；Wherein, the quality of water is to remove three
11 times of the gross mass of other all raw material components outside seven；
S2：The mixture that immersion obtains is subjected to decoction extraction, the number for decocting extraction is 3 times, is specifically included：One decocts,
The mixture that S1 has soaked to obtain is decocted into 1.6h in jacketed pan heating of boiling medicine, then with 100 mesh screens, collects first respectively
Filtrate and the first filter residue；The water of the gross mass of 11 times of other all raw material components in addition to pseudo-ginseng is added into first dregs of a decoction, is entered
Row two is decocted, and is decocted extraction 1.6h, with 100 mesh screens, is collected the second filtrate and the second filter residue respectively；Added into second dregs of a decoction
The water of the gross mass of 11 times of other all raw material components in addition to pseudo-ginseng, carry out three and decoct, extraction 1.6h is decocted, with 100 mesh sieve mistakes
Filter, the 3rd filtrate is collected, merge the first filtrate, the second filtrate and the 3rd filtrate, obtain merging filtrate；
S3：Dissolved after pseudo-ginseng is crushed with 60 DEG C of water, be then well mixed with merging filtrate, obtain admixing medical solutions；Its
In, the quality of water is 2 times of the quality of pseudo-ginseng；
S4：Admixing medical solutions are concentrated：Admixing medical solutions are once concentrated in outer circulating vacuum concentrates boiling machine, once
The temperature of concentration is 70 DEG C, obtains concentrated extract；Then concentrated extract is subjected to secondary concentration in constant temperature electric-heating container, two
The temperature of secondary concentration is 60 DEG C, receives cream when concentrated extract is concentrated into " beading of dripping ", obtains phlebitis herbal paste.
The phlebitis herbal paste that the embodiment of the present invention one to embodiment six is prepared, commented by function assessment experiment come system
Its effect of valency.
1st, toxicity test
(1) test medicine and medication
Blank control：Physiological saline, it is commercially available.
Test specimen：The phlebitis herbal paste that the embodiment of the present invention one and example IV are prepared.
Experimental animal：Rabbit, body weight 2kg or so, male and female half and half, is purchased from Experimental Animal Center.
Administration time and dosage：Using gavage mode, administration phase is 12 weeks, and convalescence is 1 week, and dosage is 0.5g/
Kg/ times, once a day.
(2) experimental method and observation index
Experimental animal is grouped at random, is divided into one group of embodiment, example IV group and blank control group, except blank control group is given
Give outside physiological saline, remaining group drug dose is 0.5g/kg/ times, every group of animal 10.Successive administration 12 weeks；Control group exists
Gavage physiological saline under the same terms.
Overview：Observe general behavior activity, fecal character, appetite and changes of weight etc., gait, mental act, the heart
Nausea and vomiting etc. are secreted and whether there is in rate, pupil size, nose and oral cavity.To 1 week after last dose from before administration 7 days, daily
Observe and record 1 time；Wherein heart rate and pupil measure 1 time for every 2 days, and body weight claims weekly 1 time.
Electrocardiographic examination：Rabbit is derived from right erect position, traces II lead, traces 2 times within 7 days before administration, traces within every 3 weeks after administration
1 time.
Blood blood examination is looked into：Extracting vein blood, red, leucocyte and hemoglobin quantitation are counted with Couter blood counts；With one
As microscopic counting blood platelet and leukocyte differential count.2 weeks before administration, per weekly check 1 time；Every 3 weekly check 1 time after administration.
Blood biochemistry checking：Venous blood sampling, anticoagulant heparin, separated plasma；Glutamic-pyruvic transaminase is determined with automatic biochemical analyzer
(GPT) and creatinine (CRTN), urea nitrogen (BUN) and sulfobromophthalein sodium (BSP) retention rate is determined with laboratory conventional method；Sampling is surveyed
Fix time same hematological examination.
Uroscopy：The red matter of urine pH, albumen, glucose, ketoboidies, UBG, courage of rabbit is checked with urine test paper and is dived
Blood etc., microscopy cast, RBC and WBC etc., time same hematological examination of taking a sample to check.
System postmortem：Every group of each work of animal in 24 hours kills 3 after last dose, and 1 week again after other rabbit last doses
Row system postmortem is entered in work.
Histological examination：Divide 2 batches, every batch every group each 5 are checked (time homologous ray postmortem).The scope of examination includes
Brain, the heart, lung, liver, kidney, adrenal gland, spleen, stomach, jejunum, pancreas and testis (hero).
Convalescence checks：Convalescence, its detection content was identical with administration phase in addition to by reagent is not given.
(3) result of the test
Overview：Each group animal does not occur obvious dry (mycteroxerosis and oral secretion after being administered 2~3 weeks
Less), Nausea and vomiting and anorexia (feed is reduced)；Activity and behavior and fecal character are had no significant effect；Body weight：Respectively
Body weight changes without obvious before and after group animal drugs；Pupil：Each group animal does not have obvious expansion pupil phenomenon；Heart rate：The each group animal heart
Rate changes equal no significant difference；Electrocardiogram：Electrocardiogram after the administration of each group animal, in addition to having stopping up property increased heart rate in early days, without it
He substantially changes；Blood biochemical：GPT, BSP retention rate, blood urea nitrogen (BUN) (BUN) and creatinine after the administration of each group animal is without bright
It is aobvious to change, show to have no significant effect hepatic and renal function；Hematology：RBC and WBC sums, Hb, blood platelet after the administration of each group animal
Had no significant change with leukocyte differential count；Urine：Urine pH, albumen after the administration of each group animal, glucose, ketoboidies, the red matter of courage
With occult blood and microscopy finding, compared with preceding and blank control group is administered, without obvious change；System postmortem：Upon administration
12 weeks and the living blank control group killed also has no with each embodiment group animal, system postmortem no significant difference, each group after being discontinued 1 week
Abnormal change；Histological examination：After the administration of each group animal after 12 weeks and drug withdrawal 1 week, do not found and medicine in 11 kinds of internal organs such as brain
The relevant pathological change of thing toxicity, and blank control group no significant difference.Conclusion：As a result show that all animals are administered 12 weeks and stopped
After medicine 1 week, urine, hematology and blood biochemical analysis inspection, system postmortem and histological examination have no significant change.Show this hair
The phlebitis herbal paste security that bright embodiment one and example IV are prepared is credible.
2nd, to lower limb dvt and lower limb deep phlebitis the effect of
Collect lower limb depth phlebothrombosis and lower limb depth phlebitis 300, age 30-72 year, average age 45 years old.Disease
Journey is most short 1 month, most long 6 years.Specifically, patient is divided into 6 groups, every group 50；Wherein, most of patients is different degrees of goes out
Now limb skin-color is red, skin temperature rise, swelling, pain, card category train of thought damp invasion of lower energizer.By first group to the 6th group difference trial edition
Inventive embodiments one eat 25g (being taken after mixing it with water with warm water) to the phlebitis herbal paste 6 weeks of embodiment six every time, and daily sooner or later each edible 1
It is secondary；Observation curative effect after 6 weeks.
Curative effect is judged as：Cure：Pain, swelling, ecchymosis, cyanosis of skin etc. disappear, and functional rehabilitation is normal.Effectively：
Pain, swelling disappear, and ecchymosis, the cyanosis of skin mitigate, and function is obviously improved, but affected part still has discomfort.It is invalid：Symptom, work(
Energy sign is without improvement.
Efficacy result：As a result it is as shown in table 1.From the results, it was seen that phlebitis herbal paste provided by the invention have it is excellent
Preventing and treating phlebitis the effect of, and safe without toxic side effect；There is whole body heating sense in some patientss therapeutic process, after medication or suffer from
There is crisp sensation in portion, finds no the toxicity of medicine, also has no allergic reaction.
The effect of 1 phlebitis herbal paste of table statistical form
| Group | Healing/name | Effectively/name | Invalid/name | Total effective rate/% |
| Embodiment one | 21 | 25 | 4 | 88% |
| Embodiment two | 18 | 26 | 6 | 88% |
| Embodiment three | 20 | 24 | 6 | 92% |
| Example IV | 45 | 5 | 0 | 100% |
| Embodiment five | 43 | 7 | 0 | 100% |
| Embodiment six | 42 | 8 | 0 | 100% |
It should be noted that except the situation that above-described embodiment one is enumerated to embodiment six, from other raw material components
It is also feasible with when preparation method parameter.
Technical scheme provided by the invention, there is following beneficial effect：(1) phlebitis herbal paste provided by the invention, choosing
It is the Chinese medicinal material containing active skull cap components, prescription proportioning science, does not add any Western medicine hormonal components, it is safe and non-toxic
Side effect；(2) phlebitis herbal paste provided by the invention has the function such as excellent prevention and/or treatment phlebitis, safe and non-toxic
Side effect；Easy to use, cost is relatively low, has good commercial promise；(3) preparation method provided by the invention is used, can
While each bulk drug active component is retained to greatest extent, the active ingredient in each raw medicinal material can be fully discharged
Come, so that the herbal paste being finally prepared not only has good drug effect, and be easy to absorb, and then be rapidly achieved treatment vein
Scorching purpose.
It should be noted that unless otherwise indicated, technical term or scientific terminology used in this application should be this hair
The ordinary meaning that bright one of ordinary skill in the art are understood.Unless specifically stated otherwise, otherwise illustrate in these embodiments
Part and relative step, numerical expression and the numerical value of step are not limit the scope of the invention.It is illustrated and described herein
In all examples, unless otherwise prescribed, any occurrence should be construed as merely exemplary, not as limitation, because
This, other examples of exemplary embodiment can have different values.
In the description of the invention, it is to be understood that term " first ", " second " are only used for describing purpose, and can not
It is interpreted as indicating or implies relative importance or imply the quantity of the technical characteristic indicated by indicating.Thus, define " the
One ", one or more this feature can be expressed or be implicitly included to the feature of " second ".In the description of the invention,
" multiple " are meant that two or more, unless otherwise specifically defined.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, either which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme, it all should cover among protection scope of the present invention.
Claims (10)
- A kind of 1. phlebitis herbal paste, it is characterised in that the raw material components of the phlebitis herbal paste by weight, including：The raw parts by weight of the Radix Astragali 205~215, the parts by weight of Radix Angelicae Sinensis 100~110, the parts by weight of Ligusticum wallichii 80~90, the weight of the red sage root 135~145 Part, the parts by weight of the radix paeoniae rubrathe 100~110, the parts by weight of giant knotweed 135~145, the parts by weight of earthworm 60~65, the parts by weight of rhizoma atractylodis 104~106 With the parts by weight of pseudo-ginseng 40~44.
- 2. phlebitis herbal paste according to claim 1, it is characterised in that the raw material components of the phlebitis herbal paste also wrap Include：The parts by weight of golden cypress 102~108, the parts by weight of honeysuckle 275~285 and the parts by weight of raw cape jasmine 82~86.
- 3. phlebitis herbal paste according to claim 2, it is characterised in that the raw material components of the phlebitis herbal paste are by weight Part meter, including：The raw parts by weight of the Radix Astragali 210, the parts by weight of Radix Angelicae Sinensis 105, the parts by weight of Ligusticum wallichii 84, the parts by weight of the red sage root 140, the parts by weight of the radix paeoniae rubrathe 105, tiger The parts by weight of cane 140, the parts by weight of earthworm 63, the parts by weight of rhizoma atractylodis 105, the parts by weight of pseudo-ginseng 42, the parts by weight of golden cypress 105, the weight of honeysuckle 280 Measure part and the raw parts by weight of cape jasmine 84.
- 4. the preparation method of the phlebitis herbal paste described in claim any one of 1-3, it is characterised in that comprise the following steps：S1：Other all raw material components in addition to pseudo-ginseng are added to the water, soak preset time；S2：The mixture that the immersion obtains is subjected to decoction extraction, collects filtrate；S3：Dissolved after pseudo-ginseng is crushed with water, be then well mixed with the filtrate, obtain admixing medical solutions；S4：The admixing medical solutions are concentrated, obtain the phlebitis herbal paste.
- 5. the preparation method of phlebitis herbal paste according to claim 4, it is characterised in that：In the S1, the quality of the water is 9~11 times of the gross mass of other all raw material components in addition to pseudo-ginseng；The leaching The time of bubble is 11~13h.
- 6. the preparation method of phlebitis herbal paste according to claim 5, it is characterised in that：In the S2, the number for decocting extraction is 3 times, and the time for decocting extraction every time is 1.4~1.6h, decocts carry every time Decoction and the dregs of a decoction are separated using 100 mesh sieves after taking；The quality of the water added every time is other institutes in addition to pseudo-ginseng There are 9~11 times of the gross mass of raw material components；The filtrate extracts the merging liquid of obtained decoction to decoct three times.
- 7. the preparation method of phlebitis herbal paste according to claim 4, it is characterised in that：In the S3, the temperature of the water is 50~60 DEG C, and the quality of the water is 1~2 times of the quality of the pseudo-ginseng.
- 8. the preparation method of phlebitis herbal paste according to claim 4, it is characterised in thatIn the S4, the concentration includes once concentration and secondary concentration：The admixing medical solutions are once concentrated, obtained dense Contracting medicinal extract；Then the concentrated extract is subjected to secondary concentration；Wherein, the temperature once concentrated is 60~70 DEG C, described The temperature of secondary concentration is 50~60 DEG C.
- 9. the preparation method of phlebitis herbal paste according to claim 4, it is characterised in that：In the S4, described be once concentrated in outer circulation vacuum concentration boiling machine is carried out, and the secondary concentration adds in constant temperature electricity Carried out in heat container.
- 10. phlebitis herbal paste the answering in the medicine for preparing prevention and/or treatment phlebitis described in claim any one of 1-3 With.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1193528A (en) * | 1997-12-19 | 1998-09-23 | 刘世国 | Capsules for paralysis and preparation thereof |
-
2017
- 2017-09-05 CN CN201710792209.XA patent/CN107412360A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1193528A (en) * | 1997-12-19 | 1998-09-23 | 刘世国 | Capsules for paralysis and preparation thereof |
Non-Patent Citations (2)
| Title |
|---|
| 朱英华: "中西医结合治疗下肢深静脉血栓的临床分析", 《中国民族民间医药》 * |
| 陈子更等: "活血通脉片临床药理研究概述", 《社区医学杂志》 * |
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