CN107402070A - A kind of skin high spectrum image collecting unit and scaling method - Google Patents

A kind of skin high spectrum image collecting unit and scaling method Download PDF

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Publication number
CN107402070A
CN107402070A CN201710407363.0A CN201710407363A CN107402070A CN 107402070 A CN107402070 A CN 107402070A CN 201710407363 A CN201710407363 A CN 201710407363A CN 107402070 A CN107402070 A CN 107402070A
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collection
light source
spectrum image
skin
collecting unit
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CN201710407363.0A
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CN107402070B (en
Inventor
陈威
王学凯
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Ai De Ghosn Medical Technology (beijing) Co Ltd
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Ai De Ghosn Medical Technology (beijing) Co Ltd
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28Investigating the spectrum
    • G01J3/2823Imaging spectrometer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02Details
    • G01J3/0256Compact construction
    • G01J3/0259Monolithic
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02Details
    • G01J3/10Arrangements of light sources specially adapted for spectrometry or colorimetry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02Details
    • G01J3/10Arrangements of light sources specially adapted for spectrometry or colorimetry
    • G01J2003/102Plural sources
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28Investigating the spectrum
    • G01J2003/2866Markers; Calibrating of scan

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  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

The present invention relates to skin high spectrum image acquisition process field, more particularly to a kind of collecting unit and scaling method of skin high spectrum image.Including power supply, light source assembly, EO-1 hyperion camera, it is optically isolated cover;Described be optically isolated on cover is provided with a collection hole, and light source assembly and EO-1 hyperion camera are arranged on described be optically isolated in cover;Under the irradiation of the light source assembly, taken pictures through EO-1 hyperion camera by collection hole and obtain skin high spectrum image in dermal harvest region;The power subsystem connection light source assembly is powered for it;Also include reference material component;Realize the correction in planar dimensions and spectral Dimensions to the skin spectrum image of collection.The present invention improves the accuracy of system by noise-reducing design;The uniformity of the collection spectroscopic data in acquisition plane, every time between collection and distinct device is ensure that, solves consistency problem.And solve collection hole and determine area (30mmx25mm) interior uniform illumination, system is provided with morphological analysis ability.

Description

A kind of skin high spectrum image collecting unit and scaling method
Technical field
The present invention relates to skin high spectrum image acquisition process field, more particularly to a kind of collection of skin high spectrum image Unit and scaling method.
Background technology
" skin spectrum prediction " model proposes its virtual skin spectrum of combination by several material composition different content Mathematical method.Hereby model, the visual effect of skin can be rendered, herein, we term it positive relationship.And " skin Skin EO-1 hyperion quantitative analysis " is then the reverse process of " skin spectrum prediction ", i.e., calculates skin by the measure spectrum of application on human skin Biological component content.Obviously, reverse process is the iteration optimization problem of positive relationship, it is necessary to solve to be applicable the essence in scene Quasi- modeling and flood tide computing technique.For quantitative analysis class medicine equipment, key index is the accuracy and speed calculated, and can Reach the requirement of clinical practice.
Hyper-spectral image technique differentiated in a manner of noninvasive, non-contacting skin biological component message context have it is only Special advantage.
Skin high-spectrum seems to be based on being gathered under visible ray (400-700nm), spacing light path system design condition. What is got by EO-1 hyperion equipment is a data cube, the image information of only not certain area, and in spectral Dimensions On deployed, as a result can not only obtain the spectroscopic data each put on image, the image of any one spectral coverage can also be obtained Information.Because spectral resolution has reached nm levels (several nm), it can fully, meticulously reflect the spy of its biological component Sign, the characteristic of " the not different spectrums of jljl, jljl is necessarily with spectrum " on the full spectral coverage of visible ray, is presented, possesses material and " refers to The effectiveness of line ", and the nuance of similar target can be distinguished, can be as the Research foundation of quantitative analysis.Compared to light more Spectrum, it possesses the simulation accuracy of full spectral coverage, eliminates " foreign matter is with spectrum " and " same object different images " phenomenon;Compared to single-point spectrum, It possesses morphological analysis ability, avoids single-point specificity and requires harsh strong point to acquisition operations, for spectrum number Possibility is provided according to more efficiently analyzing and processing is carried out.However, because the different performance of target optical spectrum and combination can be with Different features is converted into, it is necessary to establish the mathematical modeling comprising complete biological component, various dimensions, all-wave can be realized Section emulation, fine fitting.
Generally light source is mostly tungsten lamp class light source used by visible light wave range (400-700).But tungsten light source exists The spectrum spoke of 400-500nm range of wavelengths is relatively low by force, and signal to noise ratio causes the error based on EO-1 hyperion skin quantitative analysis than relatively low It is bigger, it is difficult to the basis signal as quantitative analysis.
Hyper-spectral image technique is not on the actual application also in skin analysis field.Traditional skin analysis is mainly adopted Analyzed with tissue morphology pathology method, skin is invasive collection, and general collection surface only has several millimeters, can not meet whole The needs of observation in terms of volume morphing.If using spectrometer collection mode, collection surface equally only has several millimeters.High-spectrum As technology can meet the needs that large area analyzes, but the basis signal for quantitative analysis is, it is necessary to solve unified metering and uniformly Sex chromosome mosaicism.
The content of the invention
The problem of in background technology, it is an object of the invention to:
(1) a kind of skin hyper-spectral data gathering unit is provided, by multiple light courcess configuration and LED light source Single wavelength spoke it is strong it is adjustable, The strong balancing technique of full spectral coverage spoke, makes collecting unit reach the purpose of noise reduction, so as to improve skin EO-1 hyperion quantitative analysis system Accuracy.
(2) a kind of skin hyper-spectral data gathering unit is provided, by light path design, solution homogeneity question be (30mmx25mm's Collection surface), skin EO-1 hyperion quantitative analysis system is provided with morphological analysis ability.
(3) a kind of two-stage standard correction method is provided, the consistency problem for solving system, has unified metering.
To achieve these goals, technical scheme is as follows:
A kind of skin high spectrum image collecting unit, including power supply, light source assembly, EO-1 hyperion camera, it is optically isolated cover;
Described be optically isolated on cover is provided with a collection hole, and light source assembly and EO-1 hyperion camera are arranged on described be optically isolated In cover;
Under the irradiation of the light source assembly, taken pictures through EO-1 hyperion camera by collection hole and obtain skin in dermal harvest region Skin high spectrum image;
The power subsystem connection light source assembly is powered for it;
It is characterized in that:
Also include reference material component;The reference material component includes suit blank and gradient reflecting plate, and the suit is white Plate realizes the correction in planar dimensions to the skin spectrum image of collection, and the gradient reflecting plate realizes the skin light to collection Correction of the spectrogram picture in spectral Dimensions.
Further, the light source assembly is configured using multiple light courcess, including tungsten light source and LED light source;The LED Light source is LED lamp bead of one group of wave-length coverage between 395-500nm.
Further, the LED light source sets one at interval of 5nm wavelength, is made up of 12 LED lamp beads, 4 groups altogether Symmetric arrays are set.
Further, for the power supply that the power subsystem is connected with the LED lamp bead of each wavelength using customization power supply, this is fixed Voltage, the electric current of power supply processed are individually adjusted.
Further, the suit blank includes two parts, and a part is square frame, is attached to collection square hole at random Inside, frame is also collected simultaneously when gathering object every time;Another part is square blank, is covered on collection hole, collection The panel data of target location, realize the correction of analysis plane;
The reflectivity gradient plate is 8 pieces of on-gauge plates of different reflectivity, is fitted in respectively on the outside of collection hole, collection measures Each point measured value in collection surface, realize the correction of spectral Dimensions.
Further, the 8 block gradient reflecting plate nominal reflectivity difference 100%, 80%, 60%, 40%, 20%, 10%th, 5%, 2%.
Further, the useful region after the collecting unit actual acquisition area removal dash area includes three parts:
1) effectively blank correcting area, a part for random standard white plate, are outside 100mm x 100mm, inner edge 95mm x95mm;
2) effective viewing area, it is 50mm x 50mm;
3) effective analyzed area, it is 30mm x 25mm.
A kind of scaling method for skin high spectrum image collecting unit, it is characterised in that methods described includes as follows Step:
(1) first order corrects:According to the relativeness between square blank and frame blank, to analyzing to each in region Point, the collection of each time carry out, to mark, normalization amendment, forming one-level corrected parameter table;
(2) second-order correction:Corrected by a set of gradient reflecting plate, the reference material under every block gradient reflectivity is carried out Actual measurement, the opening relationships between measured value and standard value, form the reflection of the device-dependent full spectral coverage of actual covering visible light Relation between rate detected value and variable, i.e. Second level amendment parameter list;Normalizing is carried out to every equipment, the result measured every time Change and correct, in unification to the measurement criteria of metrological service.
Further, in the step (1), when normalization is corrected, effective density 170px150p, repair for 25500 altogether On schedule;In step (2), effective density is at intervals of 10nm, 31 adjusting points altogether.
Further, the gradient reflecting plate nominal reflectivity difference 100%, 80%, 60%, 40%, 20%, 10%th, 5%, 2%.
The present invention is relative to the beneficial effect of prior art:
(1) by noise-reducing design, the accuracy of system is improved.Using the LED lamp bead of one group of different wave length to 395- 500nm wave-length coverages carry out light filling, and a LED lamp bead is taken per 5nm intervals, and one group is made up of 12 LED lamp beads, altogether using 4 groups, from And the spoke of 390-500 range of wavelengths in visible spectrum is drawn high by force;
Meanwhile customize voltage, current adjustment power supply for the LED lamp bead of each wavelength, can to each wavelength LED lamp bead voltage and Electric current is individually adjusted, and the spoke of whole visible spectrum is strong overall balanced, that is, is suitable for data processing, in turn ensure that higher noise Than.
(2) by two-stage standard correction, it ensure that the collection light in acquisition plane, between each collection and distinct device The uniformity of modal data, unified calibration, solves consistency problem.
(3) by light path design, solve collection hole and determine area (30mmx25mm) interior uniform illumination, have system There is morphological analysis ability.
Brief description of the drawings
Fig. 1 is the structural representation of the collecting unit of the present invention;
Fig. 2 is the multiple light courcess configuration schematic diagram of the present invention;
Fig. 3 is the noise reduction comparison diagram of collecting unit of the present invention;
Fig. 4 is the two level demarcation correction map of scaling method of the present invention.
In figure, 1- light source assemblies, 2- EO-1 hyperion cameras, 3- is optically isolated cover, 4- collections hole, 5- tungsten light sources, 6-LED lamps Light source.
In Fig. 3, transverse axis represents wavelength (unit nm), and the longitudinal axis is that relative spoke is strong (no unit);B line segments represent tungsten lamp transmitting light Spectrum, A line segments represent tungsten lamp and the combined light source emission spectrum of LED.
In Fig. 4, transverse axis is actual measurement reflectivity, and the longitudinal axis is standard emission rate;It is anti-that line segment 1 represents not calibrated measurement-demarcation Rate relation curve is penetrated, line segment 2 represents measurement-demarcation reflectivity corresponding relation curve after calibration.
Embodiment
With reference to the accompanying drawings and detailed description, specific embodiments of the present invention are made with detailed elaboration.These tools Body embodiment is only not used for limiting the scope of the present invention or implementation principle for narration, and protection scope of the present invention is still with power Profit requires to be defined, including obvious changes or variations made on this basis etc..
As shown in Figure 1, 2, a kind of skin high spectrum image collecting unit, including power supply, light source assembly 1, EO-1 hyperion camera 2nd, it is optically isolated cover 3;Being optically isolated cover has cavity structure, is provided with a collection hole 4, shape is not construed as limiting.Light source group Part and EO-1 hyperion camera are arranged on described be optically isolated in cover.Power subsystem connects light source assembly and powered for it.
During practical operation, dermal harvest region is by collection hole, under the irradiation of the light source assembly 1, through EO-1 hyperion phase Machine, which is taken pictures, obtains skin high spectrum image.
Present invention additionally comprises have reference material component.The reference material component includes suit blank and gradient reflecting plate, the set Correction of the blank realization to the skin spectrum image of collection in planar dimensions is filled, the gradient reflecting plate realizes the skin to collection Correction of the skin spectrum picture in spectral Dimensions.Wherein, suit blank includes two parts, and a part is square frame, at random It is attached to inside collection square hole, frame is also collected simultaneously when gathering object every time;Another part is square blank, is covered in Gather on hole, gather the panel data of target location, realize the correction of analysis plane.Reflectivity gradient plate is different reflectivity 8 pieces of on-gauge plates, fit in respectively on the outside of collection hole, collection measures each point measured value in collection surface, realizes the school of spectral Dimensions Just.
In the present invention, the nominal reflectivity of 8 block gradient reflecting plates difference 100%, 80%, 60%, 40%, 20%, 10%, 5%th, 2%.Relative to other setting numerical value, the group, which is set, make it that measurement is more accurate.
The light source assembly of the present invention is configured using multiple light courcess, including tungsten light source and LED light source;Wherein LED light source For LED lamp bead of one group of wave-length coverage between 395-500nm.LED light source sets one at interval of 5nm wavelength, by 12 LED lamp bead is formed, and 4 groups of symmetric arrays are set altogether.The power supply that power subsystem is connected with the LED lamp bead of each wavelength is using fixed Power supply processed, voltage, the electric current of the customization power supply are individually adjusted.From figure 3, it can be seen that from 400 nanometers to 550 nanometers, light source Intensity have the signal to noise ratio for being obviously improved, significantly increasing.
Useful region in the present invention after collecting unit actual acquisition area removal dash area includes three parts:
1) effectively blank correcting area, a part for random standard white plate, are outside 100mm x 100mm, inner edge 95mm x95mm;
2) effective viewing area, it is 50mm x 50mm;
3) effective analyzed area, it is 30mm x 25mm.
A kind of scaling method for skin high spectrum image collecting unit of the invention, it is characterised in that methods described bag Include following steps:
(1) first order corrects:According to the relativeness between square blank and frame blank, to analyzing to each in region Point, the collection of each time carry out, to mark, normalization amendment, forming one-level corrected parameter table;
(2) second-order correction:Corrected by a set of gradient reflecting plate, the reference material under every block gradient reflectivity is carried out Actual measurement, the opening relationships between measured value and standard value, form the reflection of the device-dependent full spectral coverage of actual covering visible light Relation between rate detected value and variable, i.e. Second level amendment parameter list;Normalizing is carried out to every equipment, the result measured every time Change and correct, in unification to the measurement criteria of metrological service.Wherein, in the step (1), when normalization is corrected, effective density is 170px150p, altogether 25500 adjusting points;In step (2), effective density is at intervals of 10nm, 31 adjusting points altogether.Gradient The nominal reflectivity difference 100%, 80%, 60%, 40%, 20%, 10%, 5%, 2% of reflecting plate.
Figure 4, it is seen that the reflectivity of measurement can obtain accurately demarcation reflectivity after calibration.

Claims (10)

1. a kind of skin high spectrum image collecting unit, including power supply, light source assembly, EO-1 hyperion camera, it is optically isolated cover;
Described be optically isolated on cover is provided with a collection hole, and light source assembly and EO-1 hyperion camera, which are arranged on, described is optically isolated cover It is interior;
Dermal harvest region is by collection hole, and under the irradiation of the light source assembly, being taken pictures through EO-1 hyperion camera, it is high to obtain skin Spectrum picture;
The power subsystem connection light source assembly is powered for it;
It is characterized in that:
Also include reference material component;The reference material component includes suit blank and gradient reflecting plate, and the suit blank is real The now correction to the skin spectrum image of collection in planar dimensions, the gradient reflecting plate realize the skin spectrum figure to collection As the correction in spectral Dimensions.
A kind of 2. skin high spectrum image collecting unit according to claim 1, it is characterised in that:
The light source assembly is configured using multiple light courcess, including tungsten light source and LED light source;The LED light source is one group of ripple LED lamp bead of the long scope between 395-500nm.
3. according to a kind of skin high spectrum image collecting unit described in claim 1, it is characterised in that:The LED light source is every It is spaced 5nm wavelength and sets one, be made up of 12 LED lamp beads, 4 groups of symmetric arrays is set altogether.
A kind of 4. skin high spectrum image collecting unit according to claim 2, it is characterised in that:
The power supply that the power subsystem is connected with the LED lamp bead of each wavelength, which uses, customizes power supply, the voltage of the customization power supply, Electric current is individually adjusted.
A kind of 5. skin high spectrum image collecting unit according to claim 1, it is characterised in that:
The suit blank includes two parts, and a part is square frame, is attached at random inside collection square hole, every time collection Frame is also collected simultaneously during object;Another part is square blank, is covered on collection hole, gathers the plane of target location Data, realize the correction of analysis plane;
The reflectivity gradient plate is 8 pieces of on-gauge plates of different reflectivity, is fitted in respectively on the outside of collection hole, collection measures collection Each point measured value in face, realize the correction of spectral Dimensions.
A kind of 6. skin high spectrum image collecting unit according to claim 5, it is characterised in that:8 block gradient is anti- Penetrate the nominal reflectivity difference 100%, 80%, 60%, 40%, 20%, 10%, 5%, 2% of plate.
A kind of 7. skin high spectrum image collecting unit according to claim 1, it is characterised in that:
Useful region after the collecting unit actual acquisition area removal dash area includes three parts:
1) effectively blank correcting area, a part for random standard white plate, are outside 100mmx100mm, inner edge 95mmx95mm;
2) effective viewing area, it is 50mmx50mm;
3) effective analyzed area, it is 30mmx25mm.
8. the scaling method of a kind of skin high spectrum image collecting unit for described in claim 1, it is characterised in that described Method comprises the following steps:
(1) first order corrects:According to the relativeness between square blank and frame blank, to analysis to each point in region, The collection of each time carries out, to mark, normalization amendment, forming one-level corrected parameter table;
(2) second-order correction:Corrected, the reference material under every block gradient reflectivity is carried out real by a set of gradient reflecting plate Survey, the opening relationships between measured value and standard value, form the reflectivity of the device-dependent full spectral coverage of actual covering visible light Relation between detected value and variable, i.e. Second level amendment parameter list;Every equipment, the result measured every time are normalized Correct, in unification to the measurement criteria of metrological service.
A kind of 9. scaling method of skin high spectrum image collecting unit for described in claim 8, it is characterised in that:It is described In step (1), during normalization amendment, effective density 170px150p, 25500 adjusting points altogether;In step (2), amendment is close Degree is at intervals of 10nm, 31 adjusting points altogether.
A kind of 10. scaling method of skin high spectrum image collecting unit for described in claim 8, it is characterised in that:
The nominal reflectivity difference 100%, 80%, 60%, 40%, 20%, 10%, 5%, 2% of the gradient reflecting plate.
CN201710407363.0A 2017-06-02 2017-06-02 A kind of skin high spectrum image acquisition unit and scaling method Active CN107402070B (en)

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Cited By (6)

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Publication number Priority date Publication date Assignee Title
CN108451501A (en) * 2018-02-01 2018-08-28 福建师范大学 A kind of nevus flammeus color and area appraisal procedure based on pixel analysis
CN112417934A (en) * 2019-08-23 2021-02-26 华为技术有限公司 Image detection method and related equipment
CN116012379A (en) * 2023-03-27 2023-04-25 皑高森德医疗器械(北京)有限责任公司 White spot grading method based on melanin volume content distribution form
CN116012484A (en) * 2023-03-27 2023-04-25 皑高森德医疗器械(北京)有限责任公司 Skin white spot basin-shaped presentation method based on volume content of melanin
CN116019425A (en) * 2023-03-27 2023-04-28 皑高森德医疗器械(北京)有限责任公司 Digital skin model based on hyperspectral image and application thereof
CN117405605A (en) * 2023-12-15 2024-01-16 浙江大学 Correction system and method for eliminating non-uniform light field distribution in hyperspectral image acquisition

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CN102435309A (en) * 2011-09-20 2012-05-02 北京农业信息技术研究中心 Field reflectance calibration method and system of agricultural imaging hyperspectral spectrometer

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CN1249444A (en) * 1998-09-28 2000-04-05 三菱电机株式会社 Method for testing spectral sensitivity characteristics of camera device, and camera data constituting method
CN102435309A (en) * 2011-09-20 2012-05-02 北京农业信息技术研究中心 Field reflectance calibration method and system of agricultural imaging hyperspectral spectrometer

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108451501A (en) * 2018-02-01 2018-08-28 福建师范大学 A kind of nevus flammeus color and area appraisal procedure based on pixel analysis
CN112417934A (en) * 2019-08-23 2021-02-26 华为技术有限公司 Image detection method and related equipment
WO2021036267A1 (en) * 2019-08-23 2021-03-04 华为技术有限公司 Image detection method and related device
CN112417934B (en) * 2019-08-23 2024-05-14 华为技术有限公司 Image detection method and related equipment
CN116012379A (en) * 2023-03-27 2023-04-25 皑高森德医疗器械(北京)有限责任公司 White spot grading method based on melanin volume content distribution form
CN116012484A (en) * 2023-03-27 2023-04-25 皑高森德医疗器械(北京)有限责任公司 Skin white spot basin-shaped presentation method based on volume content of melanin
CN116019425A (en) * 2023-03-27 2023-04-28 皑高森德医疗器械(北京)有限责任公司 Digital skin model based on hyperspectral image and application thereof
CN116019425B (en) * 2023-03-27 2023-05-23 皑高森德医疗器械(北京)有限责任公司 Digital skin model based on hyperspectral image and application thereof
CN116012379B (en) * 2023-03-27 2023-09-08 皑高森德医疗器械(北京)有限责任公司 White spot grading method based on melanin volume content distribution form
CN117405605A (en) * 2023-12-15 2024-01-16 浙江大学 Correction system and method for eliminating non-uniform light field distribution in hyperspectral image acquisition
CN117405605B (en) * 2023-12-15 2024-03-05 浙江大学 Correction system and method for eliminating non-uniform light field distribution in hyperspectral image acquisition

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