CN107397611A - A kind of interbody spinal implant - Google Patents
A kind of interbody spinal implant Download PDFInfo
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- CN107397611A CN107397611A CN201610332407.3A CN201610332407A CN107397611A CN 107397611 A CN107397611 A CN 107397611A CN 201610332407 A CN201610332407 A CN 201610332407A CN 107397611 A CN107397611 A CN 107397611A
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- Prior art keywords
- spinal implant
- interbody spinal
- polymer
- thermoplastic polymer
- porous
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/042—Iron or iron alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/045—Cobalt or cobalt alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30065—Properties of materials and coating materials thermoplastic, i.e. softening or fusing when heated, and hardening and becoming rigid again when cooled
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30772—Apertures or holes, e.g. of circular cross section
- A61F2002/30784—Plurality of holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00017—Iron- or Fe-based alloys, e.g. stainless steel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00029—Cobalt-based alloys, e.g. Co-Cr alloys or Vitallium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00035—Other metals or alloys
- A61F2310/00041—Magnesium or Mg-based alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00035—Other metals or alloys
- A61F2310/00095—Niobium or Nb-based alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00035—Other metals or alloys
- A61F2310/00131—Tantalum or Ta-based alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Prostheses (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Dispersion Chemistry (AREA)
Abstract
A kind of interbody spinal implant, its thermoplastic polymer structure body by first structure body, the second structure and between first structure body and the second structure are formed, and cavity runs through interbody spinal implant；First structure body, the second structure are made up of porous metal material, and thermoplastic polymer structure body is prepared by the composite of thermoplastic polymer and carbonyl apatite；This kind of composite is advantageous to be combined with bone tissue, whole interbody spinal implant is merged with bone tissue, is merged with bone tissue firmly.
Description
Technical field
The present invention relates to a kind of prosthese, particularly interbody spinal implant.
Background technology
The consequence of tumor of spine, Spondylitis disease and the morbidity of unstability vertebral fracture often causes serious vertebra
Body destroys, and then unstable spine and spinal cord, nerve root injury may occur, and causes patient to paralyse what is more.This patient just by
Year increase, is particularly due to aging population and accelerates to increase.And anterior spinal decompression centrum cuts entirely or subtotal ectomy is recognized
To be tumor of spine, Spondylitis disease and the main Clinical Surgery's treatment means of unstability vertebral fracture.But in hand
During art, surgeon must rebuild to the backbone for losing complete stability, be moved using autologous ilium or fibula
Plant the shortcomings of filling Reconstruction of vertebral bone defects has autologous Bone mineral change and can not provide enough instant stability after surgery.Titanium cage and
Artificial vertebral body spinal implant gradually starts clinically to be applied as a kind of effective vertebral body replacements.But make at present
Titanium cage or artificial vertebral body spinal implant are often simple mechanical support material, its own compared with autologous bone no osteoacusis,
Self-bone grafting and ostosis effect, on the premise of spinal stability is recovered, it is impossible to promote adjacent spinal section to merge；There is researcher
It is proposed to prepare centrum spinal implant using using porous material, as the A of CN 102612351 describe a kind of compound implant,
The disclosure of the invention is a kind of be easy to adjacent vertebrae fusion Interbody spinal compound implant, the implant includes by porous gold
Belong to first structure body and the second structure made of porous metal material made of material, first, second structure is constructed
Grown in into permission bone.Implant also includes being positioned between first, second structure and being attached to the first and second structures
Polymer structure so that the polymeric material of polymer structure is penetrated into the hole of the first and second soleplates, by structure
Part is combined together, and implant also includes the cavity for communicating through compound implant, and the cavity is configured for receiving bone life
Long material, in order to the fusion between two neighboring vertebra, used by the invention polymer due to be radiolucent material
Material, so as to which implant for example to observe after surgery by the imaging device of X ray by imaging device between manufactured centrum
Bone uptake or fusion via implant.But because polymeric material activity is relatively low, it is difficult to synosteosis, so that vertebra can not be realized
Spinal implant and the overall fusion of adjacent bone tissue between body.
The content of the invention：
It is an object of the invention to provide a kind of Interbody spinal implantation with adjacent bone tissue overall fusion and beneficial to clinical follow
Body.
The object of the invention is achieved through the following technical solutions：
A kind of interbody spinal implant, its first structure body made of porous metal material, is made up of porous metal material
The second structure and polymer structure is formed made of thermoplastic, polymeric materials, polymer structure positioning
Between first structure body and the second structure；Wherein, the first bonding layer bag between first structure body and polymer structure
The polymer composites in the hole for penetrating into first structure body are included, second between the second structure and polymer structure connects
Close the polymer composites in hole of the layer including penetrating into the second structure；And the sky through interbody spinal implant
Chamber, the first structure body, the modulus of elasticity of the second structure are 1.5-4GPa, and described thermoplastic, polymeric materials are thermoplastic
Property polymer composites, the thermoplastic polymer composite material is the composite of thermoplastic polymer and carbonyl apatite.
Furtherly, described interbody spinal implant, carbonyl phosphorus ash in described thermoplastic polymer composite material
Stone volume ratio is 7%-12%, like this, not only makes thermoplastic polymer composite material intensity high, and modulus of elasticity is closer to human body
Bone, and to the capacity very little through ray.
Furtherly, described interbody spinal implant, described thermoplastic polymer composite material are thermoplastic poly
The composite of compound and nanometer carbonyl apatite, nanometer carbonyl apatite and thermoplastic poly in thermoplastic polymer composite material
Compound combines more preferably, so as to performance more preferably.
Furtherly, described interbody spinal implant, described thermoplastic polymer composite material are porous material,
Hole is insertion, is advantageous to bone tissue and grows into.
Furtherly, described interbody spinal implant, the porous material that the thermoplastic polymer composite material is formed
The porosity of material is 35%-60%, and aperture is 100 μm -500 μm, is more beneficial for bone tissue and grows into.
Furtherly, described interbody spinal implant, the modulus of elasticity of the thermoplastic polymer composite material with
Within the modulus of elasticity difference 3GPa of the porous metal material of first and second structures, advantageously ensure that Interbody spinal is implanted into
Body integral, flexible modulus matches with first structure body, the second structure.
Furtherly, described interbody spinal implant, the thermoplastic polymer are polyether-ether-ketone（PEEK it is) or poly-
Methyl methacrylate (PMMA).
Furtherly, described interbody spinal implant, the porous metal material is by medical titanium and alloy, medical niobium
And prepared by alloy, Medical tantalum and alloy, medical stainless steel, Medical Cobalt-Based Alloys or medical magnesium and alloy.
Beneficial effects of the present invention：
（1）Interbody spinal implant provided by the invention, the polymer structure between first structure body and the second structure
Prepared by the composite for employing thermoplastic polymer and carbonyl apatite, this kind of material is because containing the carbonyl phosphorus for being advantageous to synosteosis
Lime stone and be advantageous to and synosteosis so that the vertebra that interbody spinal implant is prepared relative to general thermoplastic polymer structure body
Spinal implant can realize the overall fusion of interbody spinal implant and bone between body, be merged with adjacent bone tissue firmly.
（2）Carbonyl apatite volume ratio makes thermoplastic polymer compound using 7%-12% in thermoplastic polymer composite material
The strength of materials is high, and modulus of elasticity is closer to human body bone, and to the capacity very little through ray；Nanometer carbonyl apatite with
Thermoplastic polymer is combined, and helps further to improve the performances such as its intensity.
（3）Polymer structure prepared by thermoplastic polymer composite material is advantageous to bone tissue length using porous material
Enter, interbody spinal implant is more beneficial for and synosteosis.
Brief description of the drawings
Below in conjunction with accompanying drawing, the present invention is further elaborated with embodiment.
Fig. 1 is interbody spinal implant schematic diagram of the present invention, and Fig. 2 is Fig. 1 top view.
Embodiment
The embodiment of the present invention is explained below in conjunction with the accompanying drawings, embodiment is using technical solution of the present invention before
Carry, give detailed embodiment and specific operating process, but protection scope of the present invention is not limited only to following implementation
Mode.
As shown in figure 1,1 is first structure body, 2 be the second structure, and 3 be polymer structure, and 4 be the ridge between centrum
The cavity of post implant, 5 be the first bonding layer, and 6 be the second bonding layer.
Embodiment 1
A kind of interbody spinal implant, its first structure body 1 made of POROUS TITANIUM, the second structure made of POROUS TITANIUM
2 and polymer structure 3 is formed made of thermoplastic, polymeric materials, polymer structure 3 is positioned at first structure body 1
Between the second structure 2；Wherein, the first bonding layer 5 between first structure body 1 and polymer structure 3 includes penetrating into
Polymer composites in the hole of first structure body, the second bonding layer 6 between the second structure 2 and polymer structure 3
Polymer composites in hole including penetrating into the second structure；And the cavity 4 through interbody spinal implant, institute
State first structure body 1, the modulus of elasticity of the second structure 2 is 1.5GPa.Thermoplastic, polymeric materials used are thermoplastic poly
Compound composite material, the thermoplastic polymer composite material are the composite woods of thermoplastic polymer polyether-ether-ketone and carbonyl apatite
Material, the modulus of elasticity of this kind of material is 3.5 GPa.First binder course and the second joint thickness are 1.6mm.The Interbody spinal
Being implanted into preparation is：
（1）It is prepared by first structure body and the second structure, polymer structure
First structure body and the second structure are prepared using foam impregnation method.
It is prepared by polymer structure：By micron stage polyetheretherketoneresin powder and carbonyl floats according to volume ratio 9:1（Carbonyl phosphorus
Lime stone volume ratio is 10%）Uniformly mixing, is then injection molded into polymer structure.
（2）First structure body and the second structure, polymer structure are combined into interbody spinal implant
Polymer structure is heated to 160 DEG C with infrared heating mode, first structure body and the second structure sensing heating
Be heated to 420 DEG C, polymer structure is put between first structure body and the second structure, being then put into together in mould plus
Pressurize more than 3 minutes, pressure 6MPa is pressed, that is, interbody spinal implant is made.
Carbonyl apatite is mixed with the present embodiment in thermoplastic polymer polyether-ether-ketone so that polymer structure can
Combined with adjacent bone tissue, so that whole interbody spinal implant can merge with bone tissue, merged with adjacent bone tissue
Firmly.
Embodiment 2：
The embodiment is similar to Example 1, and difference is that first structure body and the second structure use porous niobium, springform
It is 7% to measure as 3.2GPa, volume accounting of the carbonyl apatite in polymer structure.
Embodiment 3：
The embodiment is similar to Example 1, and difference is that first structure body and the second structure use porous cobalt-base alloys
CoNiCrMo, modulus of elasticity 4GPa, volume accounting of the carbonyl apatite in polymer structure are 12%, the first binder course
It is 1.8mm with the second joint thickness.
Embodiment 4：
The embodiment is similar to Example 1, and difference is that first structure body and the second structure use porous stainless steel
316L, modulus of elasticity 3.7GPa, thermoplastic polymer are polymethyl methacrylate (PMMA), and carbonyl apatite uses nanometer
Carbonyl apatite, particle diameter 200nm-300nm, volume accounting of the carbonyl apatite in polymer structure are 9%.Polymer
Heating-up temperature when structure combines with first structure body, the second structure is 130 DEG C.
Embodiment 5：
The embodiment is similar to Example 1, and difference is that first structure body and the second structure use porous tantalum, springform
It is polyether-ether-ketone and the porous material of the composite preparation of nanometer carbonyl apatite to measure as 2.8GPa, polymer structure, is gathered
The preparation method of compound structure is：By micron stage polyetheretherketoneresin and particle diameter 200nm-300nm nanometer carbonyl apatite according to
Volume ratio 92:8（Carbonyl apatite volume ratio is 8%）Uniformly mixing, by NaCl that mixed powder and particle diameter are 260 μm -450 μm and
Particle diameter is 700nm-900nm nanoscale polyethylene glycol oxide according to volume ratio 9:9:2 uniformly mixing, are then injection moulded, will be into
Structure leaching in deionized water after type, that is, polyether-ether-ketone is made and gathers with the porous of the composite of nanometer carbonyl apatite
Compound structure, its hole are insertions, and aperture is 260 μm -450 μm, and porosity 55%, modulus of elasticity is 1.6 GPa.
In a word, implant provided by the present invention can cause polymer structure therein also can be with adjacent bone tissue
With reference to so that whole interbody spinal implant can merge with bone tissue, being merged with adjacent bone tissue firmly.
Claims (10)
1. a kind of interbody spinal implant, its first structure body made of porous metal material, by porous metal material system
Into the second structure and made of thermoplastic, polymeric materials polymer structure is formed, the polymer structure is determined
Position is between first structure body and the second structure；Wherein, the first bonding layer between first structure body and polymer structure
Polymer composites in hole including penetrating into first structure body, second between the second structure and polymer structure
Bonding layer includes penetrating into the polymer composites in the hole of the second structure；And the sky through interbody spinal implant
Chamber, the first structure body, the modulus of elasticity of the second structure are 1.5-4GPa, it is characterised in that described thermoplasticity polymerization
Thing material is thermoplastic polymer composite material, and the thermoplastic polymer composite material is thermoplastic polymer and carbonyl apatite
Composite.
2. interbody spinal implant as claimed in claim 1, it is characterised in that：Described thermoplastic polymer composite material
Middle carbonyl apatite volume ratio is 7%-12%.
3. interbody spinal implant as claimed in claim 1 or 2, it is characterised in that：Described thermoplastic polymer is compound
Material is the composite of thermoplastic polymer and nanometer carbonyl apatite.
4. interbody spinal implant as claimed in claim 1 or 2, it is characterised in that：Described thermoplastic polymer is compound
Material is porous material, and hole is insertion.
5. interbody spinal implant as claimed in claim 3, it is characterised in that：Described thermoplastic polymer composite material
For porous material, hole is insertion.
6. interbody spinal implant as claimed in claim 4, it is characterised in that：The thermoplastic polymer composite material structure
Into the porosity of porous material be 35%-60%, aperture is 100 μm -500 μm.
7. interbody spinal implant as claimed in claim 5, it is characterised in that：The thermoplastic polymer composite material structure
Into the porosity of porous material be 35%-60%, aperture is 100 μm -500 μm.
8. the interbody spinal implant as described in claim 1 to 7 any claim, it is characterised in that：The thermoplasticity
The modulus of elasticity of polymer composites differed with the modulus of elasticity of the porous metal material of the first and second structures 3GPa with
It is interior.
9. the interbody spinal implant as described in claim 1 to 8 any claim, it is characterised in that：The thermoplasticity
Polymer is polyether-ether-ketone（) or polymethyl methacrylate (PMMA) PEEK.
10. the interbody spinal implant as described in claim 1 to 9 any claim, it is characterised in that：The porous gold
Belong to material by medical titanium and alloy, medical niobium and alloy, Medical tantalum and alloy, medical stainless steel, Medical Cobalt-Based Alloys or medical
It is prepared by magnesium and alloy.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610332407.3A CN107397611A (en) | 2016-05-19 | 2016-05-19 | A kind of interbody spinal implant |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610332407.3A CN107397611A (en) | 2016-05-19 | 2016-05-19 | A kind of interbody spinal implant |
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| CN107397611A true CN107397611A (en) | 2017-11-28 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610332407.3A Withdrawn CN107397611A (en) | 2016-05-19 | 2016-05-19 | A kind of interbody spinal implant |
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| Country | Link |
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| CN (1) | CN107397611A (en) |
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| JP2019180796A (en) * | 2018-04-09 | 2019-10-24 | 日本特殊陶業株式会社 | Vertebral body spacer |
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| JP2019180796A (en) * | 2018-04-09 | 2019-10-24 | 日本特殊陶業株式会社 | Vertebral body spacer |
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