CN107396923A - A kind of preparation method of artemisinin slow-release body - Google Patents
A kind of preparation method of artemisinin slow-release body Download PDFInfo
- Publication number
- CN107396923A CN107396923A CN201710504282.2A CN201710504282A CN107396923A CN 107396923 A CN107396923 A CN 107396923A CN 201710504282 A CN201710504282 A CN 201710504282A CN 107396923 A CN107396923 A CN 107396923A
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- CN
- China
- Prior art keywords
- qinghaosu
- artemisinin
- slow
- release body
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to a kind of preparation method of artemisinin slow-release body, it is characterised in that：Comprise the following steps：1）Qinghaosu is dissolved with ethyl oleate, and adds cosolvent and emulsifying agent, the qinghaosu of emulsification is added in the solution of sodium alginate；2）Above-mentioned solution is instilled in the glacial acetic acid solution containing chitosan and calcium chloride, forms microballoon；3）After being cooled to room temperature, crosslinking agent is added, it is 500r/min 1000r/min control mixing speed, and crosslinking agent is glutaraldehyde or glyceraldehyde, and dosage is 1% the 4% of reaction system quality；4）Filter, with petroleum ether and distilled water flushing 58 times；5）Artemisinin slow-release body is obtained after drying 36h 72h, the present invention can effectively extend suppression time of the qinghaosu to blue-green algae in water body, reduce cost, can be applied to the natural waters such as pond, reservoir, lake, suppress the outburst of algae.
Description
Technical field
The present invention relates to a kind of preparation method of artemisinin slow-release body.
Background technology
Qinghaosu is a kind of colourless acicular crystal for extracting to obtain from compound inflorescence plant Artemisia annua i.e. Chinese medicine artemisia leaf,
Drug containing sweet wormwood, qinghaosu are not the maximally effective antimalarial specific drugs after pyrimethamine, chloroquine, primary quinoline in its stem, especially
For encephalic malaria and anti-chlorine quinoline malaria, there is the characteristics of quick-acting and less toxic, needed to use when treating disease containing qinghaosu
Capsule, but but without related research in terms of algal control of the existing qinghaosu application aspect for qinghaosu, using compared with into
Ripe microcapsules technology, applied to true water body algal control, its application field is widened, new technology way is provided for true water body algal control
Footpath.
The content of the invention
The invention aims to overcome the deficiencies in the prior art, and provide a kind of preparation side of artemisinin slow-release body
Method.
The object of the present invention is achieved like this：A kind of preparation method of artemisinin slow-release body, comprises the following steps：
1）Qinghaosu is dissolved with ethyl oleate, and adds cosolvent, adds emulsifying agent, the qinghaosu of emulsification is added into alginic acid
In the solution of sodium；Cosolvent is ethanol or methanol, and emulsifying agent is OP-10 or TWEEN-20, ethyl oleate and qinghaosu quality
Than for 12:1, the mass ratio of cosolvent and qinghaosu is 7:1, the mass ratio of emulsifying agent and qinghaosu is 2-6:1, qinghaosu and sea
The mass content of mosanom is respectively 0.2%-1% and 0.5%-4%；
2）Above-mentioned solution is instilled in the glacial acetic acid solution containing chitosan and calcium chloride, forms microballoon；In system, glacial acetic acid
Volume fraction is 2%-5%, and the mass content of chitosan and calcium chloride is respectively 0.25%-1.5% and 1%-4%；
3）After being cooled to room temperature, crosslinking agent is added, it is 500r/min-1000r/min to control mixing speed, and crosslinking agent is glutaraldehyde
Or glyceraldehyde, dosage are the 1%-4% of reaction system quality；
4）Filter, with petroleum ether and distilled water flushing 5-8 times；
5）Artemisinin slow-release body is obtained after drying 36h-72h.
Preferably, in step 5), dry temperature is not higher than 50 DEG C.
Beneficial effects of the present invention：The present invention can effectively extend suppression time of the qinghaosu to blue-green algae in water body, reduce
Cost, the natural waters such as pond, reservoir, lake can be applied to, suppress the outburst of algae.
Embodiment
Embodiment
A kind of preparation method of artemisinin slow-release body, comprises the following steps：
1）Qinghaosu is dissolved with ethyl oleate, and adds cosolvent, adds emulsifying agent, the qinghaosu of emulsification is added into alginic acid
In the solution of sodium；Cosolvent is ethanol or methanol, and emulsifying agent is OP-10 or TWEEN-20, ethyl oleate and qinghaosu quality
Than for 12:1, the mass ratio of cosolvent and qinghaosu is 7:1, the mass ratio of emulsifying agent and qinghaosu is 2-6:1, qinghaosu and sea
The mass content of mosanom is respectively 0.2%-1% and 0.5%-4%；
2）Above-mentioned solution is instilled in the glacial acetic acid solution containing chitosan and calcium chloride, forms microballoon；In system, glacial acetic acid
Volume fraction is 2%-5%, and the mass content of chitosan and calcium chloride is respectively 0.25%-1.5% and 1%-4%；
3）After being cooled to room temperature, crosslinking agent is added, it is 500r/min-1000r/min to control mixing speed, and crosslinking agent is glutaraldehyde
Or glyceraldehyde, dosage are the 1%-4% of reaction system quality；
4）Filter, with petroleum ether and distilled water flushing 5-8 times；
5）Artemisinin slow-release body is obtained after drying 36h-72h.
Preferably, in step 5), dry temperature is not higher than 50 DEG C.
The present invention weighs 0.3g qinghaosus and is dissolved in 2mL ethyl oleates, add cosolvent absolute ethyl alcohol 1.5mL when implementing,
1.5mL emulsifier op-10s are added, 50mL solution is made into distilled water, the mixing of 0.9g sodium alginates is added, is drawn with syringe
Above-mentioned mixed liquor, which instills, contain 0.25g chitosans, the glacial acetic acid content of 4g calcium chloride in 3%vt 100mL glacial acetic acid solutions,
Microballoon is formed, is cooled to after room temperature and adds 1.5mL glutaraldehydes, is filtered, with petroleum ether and distilled water flushing 5-8 times；Dry 36h-
Artemisinin slow-release body is obtained after 72h.Acute toxicity testing is carried out to the microcystic aeruginosa of sterile culture using artemisinin slow-release body,
Three parallel groups are set, and 24h is observed once, and Continuous Observation one week, when the artemisinin slow-release body weighed is 2g, it is micro- to verdigris
The 96h inhibiting rates of capsule algae reach 85%, and the present invention can effectively extend suppression time of the qinghaosu to blue-green algae in water body, reduce into
This, can be applied to the natural waters such as pond, reservoir, lake, suppress the outburst of algae.
Claims (2)
- A kind of 1. preparation method of artemisinin slow-release body, it is characterised in that：Comprise the following steps：1）Qinghaosu is dissolved with ethyl oleate, and adds cosolvent, adds emulsifying agent, the qinghaosu of emulsification is added into alginic acid In the solution of sodium；Cosolvent is ethanol or methanol, and emulsifying agent is OP-10 or TWEEN-20, ethyl oleate and qinghaosu quality Than for 12:1, the mass ratio of cosolvent and qinghaosu is 7:1, the mass ratio of emulsifying agent and qinghaosu is 2-6:1, qinghaosu and sea The mass content of mosanom is respectively 0.2%-1% and 0.5%-4%；2）Above-mentioned solution is instilled in the glacial acetic acid solution containing chitosan and calcium chloride, forms microballoon；In system, glacial acetic acid Volume fraction is 2%-5%, and the mass content of chitosan and calcium chloride is respectively 0.25%-1.5% and 1%-4%；3）After being cooled to room temperature, crosslinking agent is added, it is 500r/min-1000r/min to control mixing speed, and crosslinking agent is glutaraldehyde Or glyceraldehyde, dosage are the 1%-4% of reaction system quality；4）Filter, with petroleum ether and distilled water flushing 5-8 times；5）Artemisinin slow-release body is obtained after drying 36h-72h.
- 2. the preparation method of artemisinin slow-release body as described in the appended claim 1, it is characterised in that：In the step 5), dry Temperature is not higher than 50 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710504282.2A CN107396923A (en) | 2017-06-28 | 2017-06-28 | A kind of preparation method of artemisinin slow-release body |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710504282.2A CN107396923A (en) | 2017-06-28 | 2017-06-28 | A kind of preparation method of artemisinin slow-release body |
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| CN107396923A true CN107396923A (en) | 2017-11-28 |
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| CN201710504282.2A Pending CN107396923A (en) | 2017-06-28 | 2017-06-28 | A kind of preparation method of artemisinin slow-release body |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109769809A (en) * | 2019-02-13 | 2019-05-21 | 河海大学 | A kind of load medicine chitosan/sodium alginate sustained-release microparticle algae-inhibiting agent and preparation method |
| CN112021318A (en) * | 2020-08-21 | 2020-12-04 | 华南农业大学 | Annular pesticide slow-release agent and preparation method and application thereof |
| CN112315943A (en) * | 2020-11-19 | 2021-02-05 | 广东海洋大学 | Asiaticoside-chitosan-sodium alginate microspheres, preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102578110A (en) * | 2011-12-23 | 2012-07-18 | 河海大学 | Preparation method of artemisinin slow-release body |
-
2017
- 2017-06-28 CN CN201710504282.2A patent/CN107396923A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102578110A (en) * | 2011-12-23 | 2012-07-18 | 河海大学 | Preparation method of artemisinin slow-release body |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109769809A (en) * | 2019-02-13 | 2019-05-21 | 河海大学 | A kind of load medicine chitosan/sodium alginate sustained-release microparticle algae-inhibiting agent and preparation method |
| CN112021318A (en) * | 2020-08-21 | 2020-12-04 | 华南农业大学 | Annular pesticide slow-release agent and preparation method and application thereof |
| CN112315943A (en) * | 2020-11-19 | 2021-02-05 | 广东海洋大学 | Asiaticoside-chitosan-sodium alginate microspheres, preparation method and application thereof |
| CN112315943B (en) * | 2020-11-19 | 2022-02-25 | 广东海洋大学 | Asiaticoside-chitosan-sodium alginate microspheres, preparation method and application thereof |
| WO2022105301A1 (en) * | 2020-11-19 | 2022-05-27 | 广东海洋大学 | Asiaticoside-chitosan-sodium-alginate microsphere, and preparation method therefor and use thereof |
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Application publication date: 20171128 |