CN107375998A - A kind of surgical sutures for being mixed with bioactive substance and preparation method thereof - Google Patents
A kind of surgical sutures for being mixed with bioactive substance and preparation method thereof Download PDFInfo
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- CN107375998A CN107375998A CN201710718996.3A CN201710718996A CN107375998A CN 107375998 A CN107375998 A CN 107375998A CN 201710718996 A CN201710718996 A CN 201710718996A CN 107375998 A CN107375998 A CN 107375998A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/408—Virucides, spermicides
Abstract
The invention discloses a kind of surgical sutures for being mixed with bioactive substance for belonging to surgical medicine technical field and preparation method thereof.It is made up of the raw material of following parts by weight：80 120 parts of silk silk gum, 20 30 parts of glucan, 38 parts of common canscora herb extract, 46 parts of Chinese lantern extract, 38 parts of Herba seu Radix Cirsii Japonici, 38 parts of stone dragon extract, 5 10 parts of Angelica pubescens extract, 25 parts of glycerine, 13 parts of bisabolol.Surgical sutures prepared by the present invention have good biological safety, have no toxic side effect, it is nonirritant, with the anti-bacterium of fast short stopping blood ﹑ disappear scorching ﹑ promoting blood circulation to remove blood stasis, solve taking poison and growing muscle due, promote wound healing and prevent the functions such as adhesion, there is good blood compatibility and histocompatbility, no inflammation reaction, without human body rejection, degradable it can be absorbed after wound healing, Biodegradation Times are long, are adapted to the suture of deep wounds.
Description
Technical field
The invention belongs to surgical medicine technical field, and in particular to a kind of surgical sutures for being mixed with bioactive substance
And preparation method thereof.
Background technology
At present, surgical sutures generally use absorbable suture.Absorbable suture class mainly includes catgut and synthesis
Single.Catgut is made up of the submucous layer of small intestine of sheep.Have commonly with two kinds of chromium system, plain catgut soak time it is shorter (4~
5 days), it is used for ligation and skin closure.Chromicized catgut soak time grows (14~21) day, for suturing deep tissue.Gutstring
Belong to foreign protein, in absorption process, tissue reaction is heavier.When therefore, using excessive, excessively thick gutstring, wound inflammatory is anti-
Should be obvious.Its advantage is to be absorbed, and does not deposit foreign matter.Gutstring in 2010 is mainly used in internal organ such as stomach, intestines, bladder, ureter, courage
The suture of the mucous layers such as road, typically with 1-0 to 3-0 chromicized catgut.In addition, thicker (0~2) number chromicized catgut is then usually used in
Suture deep tissue or the peritonaeum of inflammation.Gutstring is used in the wound of infection, can be reduced due to other nonabsorbable sutures
The caused sinus for being difficult to heal.Synthetic line, kind is more, such as Dexon, Maxon, Vicryl, PDS and PVA.They
The advantages of be that tissue reaction is lighter, soak time extend, have antibacterial action.Wherein using Dexon as main representative, outward appearance is in green white
The needlework one line that alternate, multiply close weave forms.Thickness is from 6-0 to 2#.Anti-tensile force intensity is high, is not easy to break.Softness is flat
Suitable, easy surgery knots, and operating handle is good.Caused hydroxyacetic acid has bacteriostasis after hydrolysis.Fully absorbed between 60~90 days.
3-0 lines are suitable for stomach and intestine suture, and 1# lines are suitable for peritoneal suture, stndon sheath etc..
Patent 201510802572.6 discloses a kind of surgical sewing thread and preparation method thereof.It is matched somebody with somebody by following weight
The primary raw material of ratio is prepared：Collagen 58-70, chitosan 30-50, Rose Mallow Root 6-10, laxleaf millettia root 5-8, nakedflower beautyberry branchlet and leaf 4-
9, prairie fire rope 6-10, Chinese lantern 8-12, watt careless 6-11, indian skullcap herb with root 4-7, invaluable 8-13, henry clematis root of leaf 9-14, live greatly 3-7, glycerine
In right amount, appropriate azone.The suture has good biological safety, has no toxic side effect, nonirritant, has fast short stopping
Blood ﹑ detumescences stop the anti-bacterium of pain ﹑ disappear scorching ﹑ promoting blood circulation to remove blood stasis, solve taking poison and growing muscle due, promote wound healing and prevent the functions such as adhesion, have good
Blood compatibility and histocompatbility, no inflammation reaction, no human body rejection, degradable can be absorbed after wound healing, and
Catabolite is safe to the human body nontoxic, can prevent to infect, and promotes wound healing, does not produce scar.But its degradation time compared with
It is short, be not suitable for the suture of depth wound wound.
The content of the invention
It is an object of the invention to provide a kind of surgical sutures for being mixed with bioactive substance and preparation method thereof.
A kind of surgical sutures for being mixed with bioactive substance, are made up of the raw material of following parts by weight：Silk silk gum
80-120 parts, glucan 20-30 parts, common canscora herb extract 3-8 parts, Chinese lantern extract 4-6 parts, Herba seu Radix Cirsii Japonici 3-8 parts, stone
Dragon extract 3-8 parts, Angelica pubescens extract 5-10 parts, glycerine 2-5 parts, bisabolol 1-3 parts.
The extracting method of the common canscora herb extract is：Common canscora herb is dried, clayed into power, adds the water of 3-5 times of weight to return
Stream extraction 3 times, merging filtrate, is evaporated and is made.
The extracting method of the Chinese lantern extract is：Chinese lantern is dried, clayed into power, adds the water of 3-5 times of weight to return
Stream extraction 3 times, merging filtrate, is evaporated and is made.
The extracting method of the Herba seu Radix Cirsii Japonici is：Setose thistle is dried, clayed into power, adds 70% ethanol of 3-5 times of weight
Aqueous solution refluxing extraction 3 times, merging filtrate, is evaporated and is made.
The extracting method of the stone dragon extract is：Stone dragon is dried, clayed into power, adds 1% wine of 3-5 times of weight
Stone aqueous acid is soaked 3-10 days, and 5-15min is centrifuged under the conditions of 300-500rpm, takes supernatant, is evaporated and is made.
The extracting method of the Angelica pubescens extract is：The blade of Angelica pubescens is taken, is dried, is clayed into power, is added
1% aqueous tartaric acid solution of 3-5 times of weight is soaked 3-10 days, and 5-15min is centrifuged under the conditions of 300-500rpm, takes supernatant,
It is evaporated and is made.
The preparation method of the above-mentioned surgical sutures for being mixed with bioactive substance, is carried out in accordance with the following steps：
(1) silk silk gum 80-120 parts are taken, glucan 20-30 parts, is well mixed, is dissolved in 0.3-0.8mol/L glacial acetic acid
In solution, filtering, insoluble matter is removed, obtains lysate；
(2) addition common canscora herb extract 3-8 parts in the lysate prepared to step (1), Chinese lantern extract 4-6 parts, greatly
Ji extract 3-8 parts, stone dragon extract 3-8 parts, Angelica pubescens extract 5-10 parts, glycerine 2-5 parts, bisabolol 1-3
Part, stir, be put into spinning cylinder and seal, first vacuumize and heat 2-4 hours of drying, melt and in fusing point above 36-38
DEG C in nitrogen protect it is lower carry out melt spinning, coagulation forming in water coagulating bath, drawing-off in air bath, drafting multiple 4-8, then at
Nervous thermal finalization 9-15 hours, obtain suture in 55-70 DEG C of vacuum drying chamber.
Beneficial effects of the present invention：The surgical sutures of prepared by the present invention be mixed with bioactive substance have good
Biological safety, have no toxic side effect, it is nonirritant, have the anti-bacterium of fast short stopping blood ﹑ disappear scorching ﹑ promoting blood circulation to remove blood stasis, solution taking poison and growing muscle due, promote wound
Mouth heals and prevents the functions such as adhesion, has good blood compatibility and histocompatbility, no inflammation reaction, no human body rejection
Property, degradable it can be absorbed after wound healing, Biodegradation Times are long, are adapted to the suture of deep wounds.
Embodiment
With reference to specific embodiment, the present invention will be further described.
Embodiment 1
A kind of surgical sutures for being mixed with bioactive substance, are made up of the raw material of following parts by weight：Silk silk gum
100 parts, 25 parts of glucan, 6 parts of common canscora herb extract, 5 parts of Chinese lantern extract, 6 parts of Herba seu Radix Cirsii Japonici, stone dragon extract 6
Part, 8 parts of Angelica pubescens extract, 3 parts of glycerine, 2 parts of bisabolol.
The extracting method of the common canscora herb extract is：Common canscora herb is dried, clayed into power, adds the water backflow of 4 times of weight
Extraction 3 times, merging filtrate, is evaporated and is made.The extracting method of the Chinese lantern extract is：Chinese lantern is dried, clayed into power,
Add the water refluxing extraction 3 times of 4 times of weight, merging filtrate, be evaporated and be made.The extracting method of the Herba seu Radix Cirsii Japonici is：By setose thistle
Dry, clay into power, add the 70% ethanol water refluxing extraction 3 times of 4 times of weight, merging filtrate, be evaporated and be made.The stone dragon
Must the extracting method of extract be：Stone dragon is dried, clayed into power, adds 1% aqueous tartaric acid solution of 4 times of weight to soak 6 days,
10min is centrifuged under the conditions of 400rpm, takes supernatant, is evaporated and is made.The extracting method of the Angelica pubescens extract is：Take
The blade of Angelica pubescens, is dried, and is clayed into power, and adds 1% aqueous tartaric acid solution of 4 times of weight to soak 7 days, in 400rpm conditions
Lower centrifugation 8min, takes supernatant, is evaporated and is made.
The preparation method of the above-mentioned surgical sutures for being mixed with bioactive substance, is carried out in accordance with the following steps：
(1) 100 parts of silk silk gum is taken, 25 parts of glucan, is well mixed, is dissolved in 0.5mol/L glacial acetic acid solutions, mistake
Filter, insoluble matter is removed, obtains lysate；
(2) 6 parts of common canscora herb extract is added in the lysate prepared to step (1), 5 parts of Chinese lantern extract, setose thistle carries
6 parts of thing is taken, 6 parts of stone dragon extract, 8 parts of Angelica pubescens extract, 3 parts of glycerine, 2 parts of bisabolol, stirs, is put into
Sealed in spinning cylinder, first vacuumize and heat and dry 3 hours, melt and more than fusing point 37 DEG C in nitrogen protection under melted
Spinning, coagulation forming in water coagulating bath, drawing-off in air bath, drafting multiple 6, nervous heat is fixed in 60 DEG C of vacuum drying chambers
Type 12 hours, obtains suture.
Embodiment 2
A kind of surgical sutures for being mixed with bioactive substance, are made up of the raw material of following parts by weight：Silk silk gum
80 parts, 20 parts of glucan, 3 parts of common canscora herb extract, 4 parts of Chinese lantern extract, 3 parts of Herba seu Radix Cirsii Japonici, stone dragon extract 3
Part, 5 parts of Angelica pubescens extract, 2 parts of glycerine, 1 part of bisabolol.
The extracting method of the common canscora herb extract is：Common canscora herb is dried, clayed into power, adds the water backflow of 3 times of weight
Extraction 3 times, merging filtrate, is evaporated and is made.The extracting method of the Chinese lantern extract is：Chinese lantern is dried, clayed into power,
Add the water refluxing extraction 3 times of 3 times of weight, merging filtrate, be evaporated and be made.The extracting method of the Herba seu Radix Cirsii Japonici is：By setose thistle
Dry, clay into power, add the 70% ethanol water refluxing extraction 3 times of 3 times of weight, merging filtrate, be evaporated and be made.The stone dragon
Must the extracting method of extract be：Stone dragon is dried, clayed into power, adds 1% aqueous tartaric acid solution of 3 times of weight to soak 3 days,
5min is centrifuged under the conditions of 300rpm, takes supernatant, is evaporated and is made.The extracting method of the Angelica pubescens extract is：Take
The blade of Angelica pubescens, is dried, and is clayed into power, and adds 1% aqueous tartaric acid solution of 3 times of weight to soak 3 days, in 300rpm conditions
Lower centrifugation 5min, takes supernatant, is evaporated and is made.
The preparation method of the above-mentioned surgical sutures for being mixed with bioactive substance, is carried out in accordance with the following steps：
(1) 80 parts of silk silk gum is taken, 20 parts of glucan, is well mixed, is dissolved in 0.3mol/L glacial acetic acid solutions, mistake
Filter, insoluble matter is removed, obtains lysate；
(2) 3 parts of common canscora herb extract is added in the lysate prepared to step (1), 4 parts of Chinese lantern extract, setose thistle carries
3 parts of thing is taken, 3 parts of stone dragon extract, 5 parts of Angelica pubescens extract, 2 parts of glycerine, 1 part of bisabolol, stirs, is put into
Sealed in spinning cylinder, first vacuumize and heat and dry 2 hours, melt and more than fusing point 36 DEG C in nitrogen protection under melted
Spinning, coagulation forming in water coagulating bath, drawing-off in air bath, drafting multiple 4, nervous heat is fixed in 55 DEG C of vacuum drying chambers
Type 9 hours, obtains suture.
Embodiment 3
A kind of surgical sutures for being mixed with bioactive substance, are made up of the raw material of following parts by weight：Silk silk gum
120 parts, 30 parts of glucan, 8 parts of common canscora herb extract, 6 parts of Chinese lantern extract, 8 parts of Herba seu Radix Cirsii Japonici, stone dragon extract 8
Part, 10 parts of Angelica pubescens extract, 5 parts of glycerine, 3 parts of bisabolol.
The extracting method of the common canscora herb extract is：Common canscora herb is dried, clayed into power, adds the water backflow of 5 times of weight
Extraction 3 times, merging filtrate, is evaporated and is made.The extracting method of the Chinese lantern extract is：Chinese lantern is dried, clayed into power,
Add the water refluxing extraction 3 times of 5 times of weight, merging filtrate, be evaporated and be made.The extracting method of the Herba seu Radix Cirsii Japonici is：By setose thistle
Dry, clay into power, add the 70% ethanol water refluxing extraction 3 times of 5 times of weight, merging filtrate, be evaporated and be made.The stone dragon
Must the extracting method of extract be：Stone dragon is dried, clayed into power, adds the 1% aqueous tartaric acid solution immersion 10 of 5 times of weight
My god, 15min is centrifuged under the conditions of 500rpm, takes supernatant, is evaporated and is made.The extracting method of the Angelica pubescens extract
For：The blade of Angelica pubescens is taken, is dried, is clayed into power, adds 1% aqueous tartaric acid solution of 5 times of weight to soak 10 days,
15min is centrifuged under the conditions of 500rpm, takes supernatant, is evaporated and is made.
The preparation method of the above-mentioned surgical sutures for being mixed with bioactive substance, is carried out in accordance with the following steps：
(1) 120 parts of silk silk gum is taken, 30 parts of glucan, is well mixed, is dissolved in 0.8mol/L glacial acetic acid solutions, mistake
Filter, insoluble matter is removed, obtains lysate；
(2) 8 parts of common canscora herb extract is added in the lysate prepared to step (1), 6 parts of Chinese lantern extract, setose thistle carries
8 parts of thing is taken, 8 parts of stone dragon extract, 10 parts of Angelica pubescens extract, 5 parts of glycerine, 3 parts of bisabolol, stirs, puts
Enter and sealed in spinning cylinder, first vacuumize and heat and dry 4 hours, melt and more than fusing point 38 DEG C in nitrogen protection under melted
Melt spinning, coagulation forming in water coagulating bath, drawing-off in air bath, drafting multiple 8, the nervous heat in 70 DEG C of vacuum drying chambers
Sizing 15 hours, obtains suture.
Embodiment 4
A kind of surgical sutures for being mixed with bioactive substance, are made up of the raw material of following parts by weight：Silk silk gum
100 parts, 25 parts of glucan, 6 parts of common canscora herb extract, 5 parts of Chinese lantern extract, 6 parts of Herba seu Radix Cirsii Japonici, stone dragon extract 6
Part, 8 parts of Angelica pubescens extract, 3 parts of glycerine, 2 parts of bisabolol, green 3 parts of saw moss extract.
The extracting method of the common canscora herb extract is：Common canscora herb is dried, clayed into power, adds the water backflow of 4 times of weight
Extraction 3 times, merging filtrate, is evaporated and is made.The extracting method of the Chinese lantern extract is：Chinese lantern is dried, clayed into power,
Add the water refluxing extraction 3 times of 4 times of weight, merging filtrate, be evaporated and be made.The extracting method of the Herba seu Radix Cirsii Japonici is：By setose thistle
Dry, clay into power, add the 70% ethanol water refluxing extraction 3 times of 4 times of weight, merging filtrate, be evaporated and be made.The stone dragon
Must the extracting method of extract be：Stone dragon is dried, clayed into power, adds 1% aqueous tartaric acid solution of 4 times of weight to soak 6 days,
10min is centrifuged under the conditions of 400rpm, takes supernatant, is evaporated and is made.The extracting method of the Angelica pubescens extract is：Take
The blade of Angelica pubescens, is dried, and is clayed into power, and adds 1% aqueous tartaric acid solution of 4 times of weight to soak 7 days, in 400rpm conditions
Lower centrifugation 8min, takes supernatant, is evaporated and is made.It is described it is green saw moss extract extracting method be：Green saw moss is taken, dries, wears into
Powder, add 1% aqueous tartaric acid solution of 4 times of weight to soak 7 days, 8min is centrifuged under the conditions of 400rpm, takes supernatant, is evaporated system
Into.
The preparation method of the above-mentioned surgical sutures for being mixed with bioactive substance, is carried out in accordance with the following steps：
(1) 100 parts of silk silk gum is taken, 25 parts of glucan, is well mixed, is dissolved in 0.5mol/L glacial acetic acid solutions, mistake
Filter, insoluble matter is removed, obtains lysate；
(2) 6 parts of common canscora herb extract is added in the lysate prepared to step (1), 5 parts of Chinese lantern extract, setose thistle carries
Take 6 parts of thing, 6 parts of stone dragon extract, green 3 parts of saw moss extract, 8 parts of Angelica pubescens extract, 3 parts of glycerine, bisabolol 2
Part, stir, be put into spinning cylinder and seal, first vacuumize and heat and dry 3 hours, melt and more than fusing point 37 DEG C in nitrogen
Melt spinning, coagulation forming in water coagulating bath, drawing-off in air bath, drafting multiple 6, then at 60 DEG C of vacuum are carried out under gas shielded
Nervous thermal finalization 12 hours, obtain suture in drying box.
Embodiment 5
A kind of surgical sutures for being mixed with bioactive substance, are made up of the raw material of following parts by weight：Silk silk gum
100 parts, 25 parts of glucan, 6 parts of common canscora herb extract, 5 parts of Chinese lantern extract, 6 parts of Herba seu Radix Cirsii Japonici, stone dragon extract 6
Part, 8 parts of Angelica pubescens extract, 3 parts of glycerine, 2 parts of bisabolol, 1 part of tert-butyl glycinate.
The extracting method of the common canscora herb extract is：Common canscora herb is dried, clayed into power, adds the water backflow of 4 times of weight
Extraction 3 times, merging filtrate, is evaporated and is made.The extracting method of the Chinese lantern extract is：Chinese lantern is dried, clayed into power,
Add the water refluxing extraction 3 times of 4 times of weight, merging filtrate, be evaporated and be made.The extracting method of the Herba seu Radix Cirsii Japonici is：By setose thistle
Dry, clay into power, add the 70% ethanol water refluxing extraction 3 times of 4 times of weight, merging filtrate, be evaporated and be made.The stone dragon
Must the extracting method of extract be：Stone dragon is dried, clayed into power, adds 1% aqueous tartaric acid solution of 4 times of weight to soak 6 days,
10min is centrifuged under the conditions of 400rpm, takes supernatant, is evaporated and is made.The extracting method of the Angelica pubescens extract is：Take
The blade of Angelica pubescens, is dried, and is clayed into power, and adds 1% aqueous tartaric acid solution of 4 times of weight to soak 7 days, in 400rpm conditions
Lower centrifugation 8min, takes supernatant, is evaporated and is made.
The preparation method of the above-mentioned surgical sutures for being mixed with bioactive substance, is carried out in accordance with the following steps：
(1) 100 parts of silk silk gum is taken, 25 parts of glucan, is well mixed, is dissolved in 0.5mol/L glacial acetic acid solutions, mistake
Filter, insoluble matter is removed, obtains lysate；
(2) 6 parts of common canscora herb extract is added in the lysate prepared to step (1), 5 parts of Chinese lantern extract, setose thistle carries
Take 6 parts of thing, 6 parts of stone dragon extract, 8 parts of Angelica pubescens extract, 3 parts of glycerine, 2 parts of bisabolol, tert-butyl glycinate 1
Part, stir, be put into spinning cylinder and seal, first vacuumize and heat and dry 3 hours, melt and more than fusing point 37 DEG C in nitrogen
Melt spinning, coagulation forming in water coagulating bath, drawing-off in air bath, drafting multiple 6, then at 60 DEG C of vacuum are carried out under gas shielded
Nervous thermal finalization 12 hours, obtain suture in drying box.
Comparative example 1
A kind of surgical sutures for being mixed with bioactive substance, are made up of the raw material of following parts by weight：Silk silk gum
100 parts, 25 parts of glucan, 6 parts of common canscora herb extract, 5 parts of Chinese lantern extract, 6 parts of Herba seu Radix Cirsii Japonici, stone dragon extract 6
Part, 8 parts of Angelica pubescens extract, 3 parts of glycerine, 2 parts of bisabolol.
The extracting method of the common canscora herb extract is：Common canscora herb is dried, clayed into power, adds the water backflow of 4 times of weight
Extraction 3 times, merging filtrate, is evaporated and is made.The extracting method of the Chinese lantern extract is：Chinese lantern is dried, clayed into power,
Add the water refluxing extraction 3 times of 4 times of weight, merging filtrate, be evaporated and be made.The extracting method of the Herba seu Radix Cirsii Japonici is：By setose thistle
Dry, clay into power, add the 70% ethanol water refluxing extraction 3 times of 4 times of weight, merging filtrate, be evaporated and be made.The stone dragon
Must the extracting method of extract be：Stone dragon is dried, clayed into power, adds 1% aqueous tartaric acid solution of 4 times of weight to soak 6 days,
10min is centrifuged under the conditions of 400rpm, takes supernatant, is evaporated and is made.The extracting method of the Angelica pubescens extract is：Take
The root of Angelica pubescens, is dried, and is clayed into power, and adds 1% aqueous tartaric acid solution of 4 times of weight to soak 7 days, under the conditions of 400rpm
8min is centrifuged, supernatant is taken, is evaporated and is made.
The preparation method of the above-mentioned surgical sutures for being mixed with bioactive substance, is carried out in accordance with the following steps：
(1) 100 parts of silk silk gum is taken, 25 parts of glucan, is well mixed, is dissolved in 0.5mol/L glacial acetic acid solutions, mistake
Filter, insoluble matter is removed, obtains lysate；
(2) 6 parts of common canscora herb extract is added in the lysate prepared to step (1), 5 parts of Chinese lantern extract, setose thistle carries
6 parts of thing is taken, 6 parts of stone dragon extract, 8 parts of Angelica pubescens extract, 3 parts of glycerine, 2 parts of bisabolol, stirs, is put into
Sealed in spinning cylinder, first vacuumize and heat and dry 3 hours, melt and more than fusing point 37 DEG C in nitrogen protection under melted
Spinning, coagulation forming in water coagulating bath, drawing-off in air bath, drafting multiple 6, nervous heat is fixed in 60 DEG C of vacuum drying chambers
Type 12 hours, obtains suture.
Comparative example 2
A kind of surgical sutures for being mixed with bioactive substance, are made up of the raw material of following parts by weight：Silk silk gum
100 parts, 25 parts of glucan, 6 parts of common canscora herb extract, 5 parts of Chinese lantern extract, 6 parts of Herba seu Radix Cirsii Japonici, stone dragon extract 6
Part, 8 parts of Angelica pubescens extract, 3 parts of glycerine.
The extracting method of the common canscora herb extract is：Common canscora herb is dried, clayed into power, adds the water backflow of 4 times of weight
Extraction 3 times, merging filtrate, is evaporated and is made.The extracting method of the Chinese lantern extract is：Chinese lantern is dried, clayed into power,
Add the water refluxing extraction 3 times of 4 times of weight, merging filtrate, be evaporated and be made.The extracting method of the Herba seu Radix Cirsii Japonici is：By setose thistle
Dry, clay into power, add the 70% ethanol water refluxing extraction 3 times of 4 times of weight, merging filtrate, be evaporated and be made.The stone dragon
Must the extracting method of extract be：Stone dragon is dried, clayed into power, adds 1% aqueous tartaric acid solution of 4 times of weight to soak 6 days,
10min is centrifuged under the conditions of 400rpm, takes supernatant, is evaporated and is made.The extracting method of the Angelica pubescens extract is：Take
The blade of Angelica pubescens, is dried, and is clayed into power, and adds 1% aqueous tartaric acid solution of 4 times of weight to soak 7 days, in 400rpm conditions
Lower centrifugation 8min, takes supernatant, is evaporated and is made.
The preparation method of the above-mentioned surgical sutures for being mixed with bioactive substance, is carried out in accordance with the following steps：
(1) 100 parts of silk silk gum is taken, 25 parts of glucan, is well mixed, is dissolved in 0.5mol/L glacial acetic acid solutions, mistake
Filter, insoluble matter is removed, obtains lysate；
(2) 6 parts of common canscora herb extract is added in the lysate prepared to step (1), 5 parts of Chinese lantern extract, setose thistle carries
6 parts of thing is taken, 6 parts of stone dragon extract, 8 parts of Angelica pubescens extract, 3 parts of glycerine, is stirred, is put into close in spinning cylinder
Envelope, first vacuumize and heat and dry 3 hours, melt and more than fusing point 37 DEG C in nitrogen protection under carry out melt spinning, water-setting
Gu coagulation forming in bath, drawing-off in air bath, drafting multiple 6, nervous thermal finalization 12 hours in 60 DEG C of vacuum drying chambers,
Obtain suture.
Experimental example：
700 surgery patients are chosen, 7 groups is randomly divided into, every group 100, organizes Gender, age, disease and cut
There was no significant difference for the general information such as mouth species, has comparativity.The treatment method of every group of patient is identical, i.e., identical sterilization side
Method, anesthesia method, operation method, incision site etc., each layer of layering suturing them and skin are traditionally interrupted with silk thread.Than
More every group of patient's postoperative complications (being counted in postoperative 10 days), (hundred days more for infection conditions (counting for postoperative 10 days) and healing state
Conjunction rate), as a result as shown in table 1：
Table 1
As can be seen from Table 1, the postoperative complications probability of occurrence of comparative example 2 is apparently higher than other groups, with the phase of embodiment 1
Than other conditions are identical, and only comparative example 2 adds bisabolol less, it was demonstrated that bisabolol prevents postoperative appearance
The effect of complication.Hundred days healing rates of embodiment 4 are apparently higher than other groups, compared with Example 1, the complete phase of other conditions
Together, only embodiment more than 4 adds green saw moss extract, it was demonstrated that green saw moss extract has the effect of promoting wound healing.
The healing rate of comparative example 1 is significantly lower than other groups, and compared with Example 1, other conditions are identical, only in comparative example 1
The extracting method of Angelica pubescens extract is different from embodiment 1, and the raw material that embodiment 1 uses for blade, adopt by comparative example 1
Raw material is root, it is seen then that using the different parts of same raw material, generates different effects, is extracted using blade
Angelica pubescens extract have promote wound healing the effect of, and use root extraction Angelica pubescens extract do not have then
This effect.The infection rate after abortion operation of embodiment 5 is 0, hence it is evident that less than other groups, compared with Example 1, the complete phase of other conditions
Together, only embodiment more than 5 adds tert-butyl glycinate, it was demonstrated that tert-butyl glycinate has anti-infectious effect.Comparative example 2
Infection rate after abortion operation apparently higher than other groups, compared with Example 1, other conditions are identical, and only comparative example 2 adds less
Bisabolol, it was demonstrated that bisabolol has anti-infectious effect.
Claims (7)
1. a kind of surgical sutures for being mixed with bioactive substance, it is characterised in that be made up of the raw material of following parts by weight：
Silk silk gum 80-120 parts, glucan 20-30 parts, common canscora herb extract 3-8 parts, Chinese lantern extract 4-6 parts, Herba seu Radix Cirsii Japonici
3-8 parts, stone dragon extract 3-8 parts, Angelica pubescens extract 5-10 parts, glycerine 2-5 parts, bisabolol 1-3 parts.
2. the surgical sutures of bioactive substance are mixed with according to claim 1, it is characterised in that the common canscora herb carries
The extracting method for taking thing is：Common canscora herb is dried, clayed into power, adds the water refluxing extraction 3 times of 3-5 times of weight, merging filtrate, steams
It is drying into.
3. the surgical sutures of bioactive substance are mixed with according to claim 1, it is characterised in that the Chinese lantern carries
The extracting method for taking thing is：Chinese lantern is dried, clayed into power, adds the water refluxing extraction 3 times of 3-5 times of weight, merging filtrate, steams
It is drying into.
4. the surgical sutures of bioactive substance are mixed with according to claim 1, it is characterised in that the setose thistle extraction
The extracting method of thing is：Setose thistle is dried, clayed into power, adds the 70% ethanol water refluxing extraction 3 times of 3-5 times of weight, is closed
And filtrate, it is evaporated and is made.
5. the surgical sutures of bioactive substance are mixed with according to claim 1, it is characterised in that the stone dragon carries
The extracting method for taking thing is：Stone dragon is dried, clayed into power, adds the 1% aqueous tartaric acid solution immersion 3-10 of 3-5 times of weight
My god, 5-15min is centrifuged under the conditions of 300-500rpm, takes supernatant, is evaporated and is made.
6. the surgical sutures of bioactive substance are mixed with according to claim 1, it is characterised in that the heavy peristome is worked as
The extracting method for returning extract is：The blade of Angelica pubescens is taken, is dried, is clayed into power, adds 1% tartaric acid of 3-5 times of weight
Aqueous solution soaking 3-10 days, centrifuges 5-15min under the conditions of 300-500rpm, takes supernatant, is evaporated and is made.
7. the preparation method of the surgical sutures of bioactive substance is mixed with described in claim 1, it is characterised in that according to such as
Lower step is carried out：
(1) silk silk gum 80-120 parts are taken, glucan 20-30 parts, is well mixed, is dissolved in 0.3-0.8mol/L glacial acetic acid solutions
In, filtering, insoluble matter is removed, obtains lysate；
(2) common canscora herb extract 3-8 parts, Chinese lantern extract 4-6 parts are added in the lysate prepared to step (1), setose thistle carries
Thing 3-8 parts are taken, stone dragon extract 3-8 parts, Angelica pubescens extract 5-10 parts, glycerine 2-5 parts, bisabolol 1-3 parts, are stirred
Mix uniformly, be put into spinning cylinder and seal, first vacuumize and heat 2-4 hours of drying, melt and in 36-38 DEG C of the fusing point above in nitrogen
Melt spinning, coagulation forming in water coagulating bath, drawing-off in air bath, drafting multiple 4-8, then at 55-70 are carried out under gas shielded
Nervous thermal finalization 9-15 hours in DEG C vacuum drying chamber, obtain suture.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0140596A2 (en) * | 1983-10-04 | 1985-05-08 | JOHNSON & JOHNSON | Protein/polysaccharide complexes |
| CN101700409A (en) * | 2009-11-20 | 2010-05-05 | 佘振定 | Material prepared from purely natural material and used for wounds |
| CN103143066A (en) * | 2013-02-01 | 2013-06-12 | 北京市理化分析测试中心 | Novel composite for medicine carrying of medical equipment |
| US20150031629A1 (en) * | 2013-02-12 | 2015-01-29 | Silktears, Inc. | Ophthalmic formulation derived from silk protein |
| CN104940989A (en) * | 2015-06-24 | 2015-09-30 | 苏州乔纳森新材料科技有限公司 | Absorbable suture line and method for preparing the same |
| CN105288718A (en) * | 2015-11-19 | 2016-02-03 | 耿文真 | Surgical operation suture and preparation method thereof |
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2017
- 2017-08-21 CN CN201710718996.3A patent/CN107375998A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0140596A2 (en) * | 1983-10-04 | 1985-05-08 | JOHNSON & JOHNSON | Protein/polysaccharide complexes |
| CN101700409A (en) * | 2009-11-20 | 2010-05-05 | 佘振定 | Material prepared from purely natural material and used for wounds |
| CN103143066A (en) * | 2013-02-01 | 2013-06-12 | 北京市理化分析测试中心 | Novel composite for medicine carrying of medical equipment |
| US20150031629A1 (en) * | 2013-02-12 | 2015-01-29 | Silktears, Inc. | Ophthalmic formulation derived from silk protein |
| CN104940989A (en) * | 2015-06-24 | 2015-09-30 | 苏州乔纳森新材料科技有限公司 | Absorbable suture line and method for preparing the same |
| CN105288718A (en) * | 2015-11-19 | 2016-02-03 | 耿文真 | Surgical operation suture and preparation method thereof |
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Application publication date: 20171124 |