CN107375915A - A kind of natural nutrition composition and its application in pharmacy - Google Patents
A kind of natural nutrition composition and its application in pharmacy Download PDFInfo
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- CN107375915A CN107375915A CN201710430294.5A CN201710430294A CN107375915A CN 107375915 A CN107375915 A CN 107375915A CN 201710430294 A CN201710430294 A CN 201710430294A CN 107375915 A CN107375915 A CN 107375915A
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- Prior art keywords
- thrombus
- nutrition composition
- natural nutrition
- enzyme
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21001—Chymotrypsin (3.4.21.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21004—Trypsin (3.4.21.4)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21062—Subtilisin (3.4.21.62)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/22—Cysteine endopeptidases (3.4.22)
- C12Y304/22004—Bromelain (3.4.22.4)
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a kind of natural nutrition composition and its application in pharmacy, natural nutrition composition, including the enzyme of therapeutically effective amount, lycopene, grape seed extract and pharmaceutically acceptable auxiliary material；Described enzyme be papain, bromelain, trypsase, chymotrypsin, pancreatin, Nattokinase, Lumbrokinase or Collagenase in one kind and more than.The present invention has obvious therapeutic action, the also effect with strengthen immunity, prevention diabetes and pre- anti-cancer to angiocardiopathies such as cerebral thrombus, coronary heart disease, lung thrombus, can be used for preparing treatment cardiovascular disease medicine.The present invention combines the material with anti-inflammatory and antioxidation by a certain percentage, with obvious the effect for the treatment of thrombus, has auxiliary therapeutic action to angiocardiopathy, diabetes, hypertension.Natural active matter, it is nontoxic, it is long-term use of, it is safely and effectively alimentation composition without dependence.
Description
Technical field
The present invention relates to a kind of natural nutrition composition containing enzyme and its application.
Technical background
Cerebral thrombus is most common one kind in ICVD, mainly in hypertension and atherosclerosis base
On plinth, cerebral artery vessel wall thickening, luminal stenosis, tube wall inner membrance is rough, and VPV slows down.When the narrow cerebrovascular is sent out
Life is completely plugged, just causes the pathological changes such as local brain tissue ischemic, softening, necrosis, so as to produce hemiplegia, aphasia, feel barrier
A series of symptom of neurological dysfunctions such as hinder.The number that cerebral thrombosis disease is died from the whole world every year is up to 15,000,000 people, China
Die from nearly 3,000,000 people of cerebral thrombosis disease every year.Cerebral thrombosis disease has the characteristics of illness rate is high, fatal rate is high and the death rate is high,
It is the first to occupy the various causes of the death.
Treatment of the medical field for cerebral thrombus at present, the general medicine using expansion blood vessel and thrombus enter row vein note
Penetrate, so that the platelet thrombus, mixed thrombus, microthrombus or infective thrombus thing in the cerebrovascular disappear.The anti-freezing that uses, thrombolysis
Medicine is mostly Defibrase, the red sage root, troxerutin, Ticlopidine, aspirin etc..The existing medicine used is due to passing through tip
Vein blood vessel enters blood circulation system, so the therapeutic action played for the embolism of cerebral artery vessel has been very faint
So that the therapeutic effect of cerebral thrombus is undesirable.
The content of the invention
It is an object of the invention to provide a kind of natural nutrition composition and its application in pharmacy, to overcome prior art
The defects of existing.
Natural nutrition composition of the present invention, including the enzyme of therapeutically effective amount, lycopene, grape seed extract and
Pharmaceutically acceptable auxiliary material, said composition can remove the metabolite in blood, strengthen blood oxygen carrying capacity；
Described enzyme is papain, bromelain, trypsase, chymotrypsin, pancreatin, Nattokinase, earthworm swash
One kind in enzyme or Collagenase etc. is in the above；
Described auxiliary material such as diluent, excipient (such as water) etc., filler such as starch, sucrose, lactose, microcrystalline cellulose
Deng, adhesive such as cellulose derivative, gelatin and polyvinylpyrrolidone etc., wetting agent such as glycerine etc., surfactant such as ten
Six alkanols etc., disintegrant such as calcium carbonate, PVPP, sodium carboxymethyl starch etc., lubricant such as talcum powder, stearoyl-fumarate
Sodium, calcium stearate and magnesium etc., such as spices, sweetener, liquid or solid filler or diluent common carrier material, preparation are usual
Contain the active ingredient that percentage by weight is 35~60%；
Preferably, described natural nutrition composition, the component of following percentage by weight is included：
Preferably：
Described papain can use the product of German AB enzyme preparations company；
Described bromelain can use the product of German AB enzyme preparations company；
Described trypsase can use the product of German Ying Lian enzyme preparations company；
Described chymotrypsin is a kind of proteolytic enzyme of pancreatic secretion, using the production of German Ying Lian enzyme preparations company
Product；
Described pancreatin is the mixture of trypsase, amylopsin, pancreatic lipase, is produced using German AB enzyme preparations company
Product；
Other enzymes such as the Nattokinase, Lumbrokinase use the product of German Ying Lian enzyme preparations company
Grape seed extract can use document：Wang Lu, Zheng Maoqiang, Wang Meng, Wang Siwei《The separation of grape pip procyanidin is pure
Change research》, it is prepared by the method for (grain and food industry, Vol.16,2009, No.1) report；
The preparation method of the present invention is conventional, after each component is mixed, using method well known in the art, tabletting,
Enteric coating or capsule charge；
Experiment proof, natural nutrition composition of the present invention, to cardiovascular diseases such as cerebral thrombus, coronary heart disease, lung thrombus
Disease has obvious therapeutic action, the also effect with strengthen immunity, prevention diabetes and pre- anti-cancer, can be used for preparation and controls
Treat cardiovascular disease medicine.
The natural nutrition composition of the present invention, can be by orally putting on the patient for needing to take, generally, dosage
For 20mg~60mg/ days/kg body weight, can specifically be determined according to age of patient etc. by doctor；
The invention has the advantages that the material with anti-inflammatory and antioxidation is combined by a certain percentage, it is allowed to have
There is the effect of obvious treatment thrombus, have auxiliary therapeutic action to angiocardiopathy, diabetes, hypertension.Natural active matter,
It is nontoxic, it is long-term use of, it is safely and effectively alimentation composition without dependence.
Embodiment
Embodiment 1
Preparation method：After each component is mixed, using method well known in the art, tabletting, it is coated and obtains tablet, every
Weight is 0.70mg；
It is coated the enteric coated products that powder supplies using happy Kandy is blocked；
Clinical observation：
(1) clinical data
180 cerebral thrombus patients are carried out with clinical tests, these patients have different degrees of limbs are numb, motion not
Spirit, glossolalia, speak ambiguous or aphasia, hemiplegia, and course of disease 1-3.Man 120, female 60.Treatment group 104, it is right
According to group 76.
(2) treatment method
Control group routinely gives troxerutin；The oral present composition for the treatment of group, 2 times a day, 2 tablets once；Cycle 28
My god
(3) curative effect determinate standard：
It is effective：Limb motion is flexible, and language performance is clear or comprehension of aphasia: semantic processing more visible can be expressed, without spinning sensation.
Effectively：Limbs picotement declines, and motion is more flexible, and language performance is more visible or comprehension of aphasia: semantic processing can be with sounding, spinning sensation
Mitigate.
It is invalid：Limb motion is dumb, glossolalia is unclear or aphasia, dizziness are without improvement.
(4) clinical test results are as follows：
| It is clinical | It is effective | Effectively | It is invalid | Total effective rate (%) |
| Treatment group | 70 | 28 | 6 | 92.45 |
| Control group | 38 | 14 | 24 | 68.42 |
| P values | <0.01 | <0.01 |
In subsequent long-term efficacy investigation, treatment group patient is not recurred substantially.
Embodiment 2
Preparation method：With embodiment 1；
Zoopery
(1) Animal Model
1.1 animal：Wistar rats 60, body weight about 260g, male and female are unlimited, by Capital University of Medical Sciences's Experimental Animal Center
There is provided；
1.2 method for establishing model
With 10% chloraldurate 3ml/kg intraperitoneal anesthesias, stringer otch is hit exactly in neck, isolates right carotid master
The dry 3cm that is about separates out internal carotid in hyoid bone horizontal separation ligation each branch of external carotid artery and cervical enlargement punishment.Noninvasive artery clamp
Folder closes internal carotid opening and arteria carotis communis proximal part respectively.Ligation external carotid artery distal end is placed in conduit in external carotid artery trunk
Drive in the wrong direction and be inserted in arteria carotis communis.Thrombus is made in taking whole blood 2ml to add 125U fibrin ferments in conduit.Thrombus is cut into after 40min
The thrombus of 0.2mm*0.5mm sizes, 1ml mixed liquors are made with physiological saline.Thrombus mixed liquor is slowly injected into arteria carotis communis, pulled out
Except conduit and ligature external carotid artery near-end.Open internal carotid and arteria carotis communis.
1.3 test method
Moulding success Wistar rats 40 are chosen, are randomly divided into 5 groups, every group 8.I.e. Cerebrovascular embolism model group, positive group
(urokinase group 12500u/kg) and the basic, normal, high dosage group of alimentation composition (5000u/kg, 12500u/kg, 25000u/kg) agent
Amount group.Cycle：2 weeks
1.4 result
Behavior scoring is carried out with reference to Bederson etc. method, its behavior scoring result shows：With alimentation composition it is low,
Middle and high dosage group and the positive group of behavior symptom to rat have different degrees of improvement, have compared with model group (urokinase)
Significant difference.And the effect of nutrition group high dose group is slightly better than positive controls.
Influence of the sample to rat behavior defect level
| Group | Dosage (u/kg) | N | Behavior scoring value |
| Model group | 8 | 6.67±1.21 | |
| Alimentation composition is low | 5000 | 8 | 4.00±1.16** |
| In alimentation composition | 12500 | 8 | 2.9±1.12** |
| Alimentation composition is high | 25000 | 8 | 1.78±1.27** |
| Positive group (urokinase) | 12500 | 8 | 2.15±1.56** |
Note：*, p<0.01；Compared with model group is at same time point.
Claims (6)
1. natural nutrition composition, it is characterised in that enzyme, lycopene, grape seed extract and doctor including therapeutically effective amount
Pharmaceutically acceptable auxiliary material；
Described enzyme be papain, bromelain, trypsase, chymotrypsin, pancreatin, Nattokinase, Lumbrokinase or
One kind in Collagenase is in the above.
2. natural nutrition composition, it is characterised in that include the component of following percentage by weight：
3. natural nutrition composition, it is characterised in that include the component of following percentage by weight：
4. the natural nutrition composition according to claim 1,2 or 3 is preparing the application in treating cardiovascular disease medicine.
5. application according to claim 4, it is characterised in that described angiocardiopathy is cerebral thrombus, coronary heart disease or lung
Thrombus.
6. application according to claim 5, it is characterised in that by orally putting on the patient for needing to take, dosage is
20mg~60mg/ days/kg body weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710430294.5A CN107375915A (en) | 2017-06-09 | 2017-06-09 | A kind of natural nutrition composition and its application in pharmacy |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710430294.5A CN107375915A (en) | 2017-06-09 | 2017-06-09 | A kind of natural nutrition composition and its application in pharmacy |
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| Publication Number | Publication Date |
|---|---|
| CN107375915A true CN107375915A (en) | 2017-11-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710430294.5A Pending CN107375915A (en) | 2017-06-09 | 2017-06-09 | A kind of natural nutrition composition and its application in pharmacy |
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| Country | Link |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102726732A (en) * | 2012-06-04 | 2012-10-17 | 于长富 | Nutritional supplement of foods for controlling cardiovascular disease, and its application |
| CN105232523A (en) * | 2015-10-08 | 2016-01-13 | 成都普瑞法科技开发有限公司 | Natural drug combination for preventing and treating cardiovascular diseases and application thereof |
| CN105770870A (en) * | 2014-12-24 | 2016-07-20 | 上海宣泰生物科技有限公司 | Enzyme-contained natural composition and application thereof in pharmacy |
-
2017
- 2017-06-09 CN CN201710430294.5A patent/CN107375915A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102726732A (en) * | 2012-06-04 | 2012-10-17 | 于长富 | Nutritional supplement of foods for controlling cardiovascular disease, and its application |
| CN105770870A (en) * | 2014-12-24 | 2016-07-20 | 上海宣泰生物科技有限公司 | Enzyme-contained natural composition and application thereof in pharmacy |
| CN105232523A (en) * | 2015-10-08 | 2016-01-13 | 成都普瑞法科技开发有限公司 | Natural drug combination for preventing and treating cardiovascular diseases and application thereof |
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| PB01 | Publication | ||
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| WD01 | Invention patent application deemed withdrawn after publication | ||
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Application publication date: 20171124 |