CN107375490A - 一种橘叶鲜榨喷雾干燥颗粒饮片及其制备工艺 - Google Patents
一种橘叶鲜榨喷雾干燥颗粒饮片及其制备工艺 Download PDFInfo
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Abstract
本发明公布了一种橘叶鲜榨喷雾干燥颗粒饮片及其制备工艺。该工艺在橘叶药材采收后，净选、淋洗，并趁鲜压榨，滤取药汁。药渣再加水搅拌，过滤压榨。所得药汁合并后减压浓缩，喷雾干燥,装袋，真空封装。此法制备的橘叶颗粒饮片，最大限度的保留了药材中的有效成分。颗粒饮片流动性好，便于储运，方便调剂，质量可控，疗效可靠，对保障中医药临床疗效具有重要的意义。本法的推广实施，将有显著的社会意义和经济效益。
Description
技术领域
本发明属于中药材加工领域，尤其涉及中药橘叶饮片的加工工艺。
背景技术
中药橘叶为芸香科植物橘树Citrus reticulata Blanco的干燥叶片。本品具有疏肝，行气，化痰，消肿毒的功效。可治疗胁痛、肺痈、疝气等的治疗。
常用的橘叶饮片的加工方式为：采收后除去杂质，晒干，打包储藏和运输。此类中药饮片，体积庞大，容易污染和霉变，卫生学条件差，质量很难保证，不利于配方调剂和确保其临床疗效。
目前，市场上也有橘叶药材经过提取后制成的颗粒饮片销售。由于颗粒饮片制备过程中，提取不仅耗时耗能，而且因常用水做溶媒，药材中的非极性有效成分很难被提取出来。此外，由于提取用的橘叶药材也是干燥并经过长时间储藏的，因此，有效成分的损失也是很大的。为了确保橘叶药材的临床有效、质量稳定，一种新型的橘叶饮片及其制备工艺亟待开发。
发明内容
本发明公布了 “一种橘叶鲜榨喷雾干燥颗粒饮片及其制备工艺”。本工艺可以最大限度的保留橘叶药材中的极性和非极性有效成分，避免药材在现有的饮片加工和储运过程中引起的有效成分的丢失和药材品质的下降，减少药材受霉菌等的污染，对确保橘叶饮片的质量稳定和临床安全有效具有重要的意义。
为了实现上述目的，本发明的技术方案为：
在橘叶采收后，洗净，切成1~2cm的段，加入药材重量0.5~1倍量的水，搅拌15~30分钟，趁鲜压榨，收集初榨药汁，药渣加入1~5倍量的水，搅拌5~30min，压榨取汁，所剩药渣再加入1~5倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，100~200目筛过滤，得橘叶药汁。将所得的橘叶药汁，40~80℃减压浓缩，所得相对密度为1.02~1.10的浓缩液喷雾干燥，进风口温度为90~120℃，出风口温度为70~100℃，收集喷干产物并粉碎，过60目筛，真空包装即可。
在产品包装袋的标签上，印刷上品名、药用部位、种植地、生产商、生产日期、主要成分含量、性味归经、功能主治、用法用量、毒副作用及禁忌证等信息。袋内附上橘叶的薄层鉴别图谱和/或高效液相特征图谱，作为产品的“身份证”。此外，在产品的包装袋上，印有二维码，通过扫描可以链接获取产品的原植物照片、药材照片、饮片照片、性状及显微鉴别特征等信息。
本发明的有益之处在于：
新鲜橘叶药材净选洗涤后直接压榨、过滤、减压浓缩、喷雾干燥、分离挥发油、环糊精包合、混合制粒，所得到的颗粒饮片，可以最大限度地完整保留药材中的有效成分，特别是对保留挥发性有效成分，具有重要意义。 这种饮片体积较之于传统饮片体积大大地减小，质量更加稳定，颗粒流动性好，利于储运和临床调剂，具有十分显著的社会意义和经济意义。
具体实施方式
实施例1
将新鲜采集的橘叶药材，洗净，切成1cm的段，加入药材重量0.5倍量的水，搅拌15分钟，趁鲜压榨，收集初榨药汁，药渣加入1~5倍量的水，搅拌5~30min，压榨取汁，所剩药渣再加入3倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，100目筛过滤，得橘叶药汁。将所得的橘叶药汁，减压浓缩，温度设定为65℃。在浓缩液相对密度为1.05时，喷雾干燥，进风口温度为110℃，出风口温度为80℃，收集干燥物并粉碎，过60目筛，真空封装，贴签即可。
实施例2
将新鲜采集的橘叶药材，洗净，切成2cm的段，加入药材重量1倍量的水，搅拌30分钟，趁鲜压榨，收集初榨药汁，药渣加入1~5倍量的水，搅拌10min，压榨取汁，所剩药渣再加入4倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁， 200目筛过滤，得橘叶药汁。将所得的橘叶药汁，减压浓缩，温度设定为70℃。在浓缩液相对密度为1.03时，喷雾干燥，进风口温度为100℃，出风口温度为90℃，收集干燥物并粉碎，过60目筛，真空封装，贴签即可。
以上实施例，仅为说明本项发明的技术思想，不能凭此限定本发明的保护范围 凡是按照本发明提出的技术思想，在技术方案基础上所做的任何改动，均落入本发明保护的范围之内。
Claims (2)
1.一种橘叶鲜榨喷雾干燥颗粒饮片及其制备工艺，其特征在于：在橘叶采收后，洗净，切成1~2cm的段，加入药材重量0.5~1倍量的水，搅拌15~30分钟，趁鲜压榨，收集初榨药汁，药渣加入1~5倍量的水，搅拌5~30min，压榨取汁，所剩药渣再加入1~5倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，100~200目筛过滤，得橘叶药汁。
2.根据权利要求1所述的一种橘叶鲜榨喷雾干燥粉末饮片及其制备工艺，其特征在于：将权利要求1中所得的橘叶药汁，40~80℃减压浓缩，所得相对密度为1.02~1.10的浓缩液喷雾干燥，进风口温度为90~120℃，出风口温度为70~100℃，收集喷干产物并粉碎，真空包装即可。
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