CN107374766B - Mechanical device for generating animal hypertrophic scars - Google Patents
Mechanical device for generating animal hypertrophic scars Download PDFInfo
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- CN107374766B CN107374766B CN201710708748.0A CN201710708748A CN107374766B CN 107374766 B CN107374766 B CN 107374766B CN 201710708748 A CN201710708748 A CN 201710708748A CN 107374766 B CN107374766 B CN 107374766B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D1/00—Surgical instruments for veterinary use
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
- G01L5/00—Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Force Measurement Appropriate To Specific Purposes (AREA)
- Investigating Strength Of Materials By Application Of Mechanical Stress (AREA)
Abstract
The invention discloses a mechanical device for generating animal hypertrophic scars, which comprises a skin test mechanical bracket for measuring the tension of skin and a scar manufacturing bracket for establishing the hypertrophic scars according to the test tension; the scar manufacturing bracket comprises two skin brackets, two force application connecting blocks and a rotating screw rod; the two skin brackets are symmetrically arranged, and each skin bracket is provided with a fixing hole for combining with skin; a force application connecting block is connected with a corresponding skin bracket through a fixed hoop combination; threaded holes are formed in the middle of the two force application connecting blocks, and the directions of the two threads are opposite; the rotating screw is sequentially connected with the two force application connecting blocks in a threaded manner; the two sides of the rotating screw rod are respectively provided with a sliding rod, and the force application connecting block can slide along the sliding rods. The mechanical device is used for continuously applying certain mechanical stress to wounds in rodent experimental animal healing and simulating the natural tension of human skin.
Description
Technical Field
The invention belongs to the technical field of biomedical experiments, and relates to a mechanical device for generating animal hypertrophic scars.
Background
The hypertrophic scar often occurs after burn and wound, the incidence rate of China is high, and an effective control method is not available because the occurrence mechanism is still unknown. Thus, the establishment of animal models for researching the pathogenesis of hypertrophic scars is urgently needed. However, rodents widely used to model animals do not produce significant hypertrophic scars after trauma, and so in vivo studies of the mechanism of hypertrophic scarring have progressed slowly. It is reported in the literature that the tension of tissues such as skin is an important factor affecting hypertrophic scar formation, whereas rodent laboratory animals are pinus animals whose skin tension is much less than that of humans.
Disclosure of Invention
In order to solve the defects existing in the prior art, the invention provides a mechanical device for generating animal hypertrophic scars; the mechanical device is used for continuously applying certain mechanical stress to wounds in rodent experimental animal healing, simulating the natural tension of human skin, stimulating the generation of scar tissues, and establishing a hypertrophic scar animal model to study the occurrence, development and influence factors thereof.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
a mechanical device for creating a hypertrophic scar in an animal comprising a mechanical scaffold for testing the skin with a measure of skin tension and a scar-making scaffold for creating a hypertrophic scar based on the test tension;
the scar manufacturing bracket comprises two skin brackets, two force application connecting blocks and a rotating screw rod; the two skin brackets are symmetrically arranged, and each skin bracket is provided with a fixing hole for being connected with skin suture; a force application connecting block is connected with a corresponding skin bracket through a fixed hoop combination; threaded holes are formed in the middle of the two force application connecting blocks, and the directions of the two threads are opposite; the rotating screw is sequentially connected with the two force application connecting blocks in a threaded manner; the two sides of the rotating screw rod are respectively provided with a sliding rod, and the force application connecting block can slide along the sliding rods.
The skin test mechanical support comprises two force measuring connecting blocks and a force measuring screw rod; the two skin brackets are symmetrically arranged; a force measuring connecting block is connected with a corresponding skin bracket through a fixing hoop combination; the middle parts of the two force-measuring connecting blocks are provided with through holes, the through holes of the first force-measuring connecting block are threaded holes, and the through holes of the second force-measuring connecting block are smooth holes; the force measuring screw rod sequentially passes through the through holes of the two force measuring connecting blocks, a threaded structure matched with the threaded hole of the first force measuring is arranged on one side of the force measuring screw rod, provided with the groove, of the blind buckle, and the part, except the threaded structure, of the force measuring screw rod is of a smooth structure; the two sides of the force measuring screw rod are respectively provided with a sliding rod, and the force measuring connecting block can slide along the sliding rods.
The force measuring connecting block is arranged in a clamping groove of the fixing hoop combination, and the force measuring connecting block and the skin bracket are fixed into a whole through screws on two sides of the fixing hoop combination.
The force measuring screw rod is connected with the chest expander through the hidden buckle side of the groove.
The skin support is of an axisymmetric wing-shaped structure, and a plurality of fixing holes are symmetrically formed in the skin support.
The bottom of the skin bracket is smooth.
The force application connecting block is arranged in a clamping groove of the fixed hoop combination, and the fixed hoop combination enables the force application connecting block and the skin bracket to be fixed into a whole through screws on two sides.
The middle part of the rotating screw is provided with an annular bulge, and the annular bulge is arranged between the two force application connecting blocks.
Compared with the prior art, the invention has the following advantages:
the invention is composed of a skin test mechanical bracket and a scar manufacturing bracket, wherein the skin test mechanical bracket is used for measuring the skin bearing tension, then the scar manufacturing bracket is used for building a proliferative scar according to the test tension, a certain mechanical stress is continuously applied to a wound in the healing of a rodent experimental animal, the natural tension of human skin is simulated, the generation of scar tissues is stimulated, and an animal model of the proliferative scar is built to study the occurrence, the development and the influence factors of the scar. The device simple structure through exerting rotatory external force, converts the tension into the thrust to skin on two skin support 1 to two skin support 1 reasonable simulation skin's that set up tension circumstances, the practical condition, experimental simulation authenticity is high.
Drawings
FIG. 1 is a schematic illustration of a skin test mechanical stent;
FIG. 2 is a schematic diagram of in vivo scar manufacturing of an animal stent;
FIG. 3 is a perspective view of the device;
Detailed Description
As shown in fig. 1, a mechanical device for creating a hypertrophic scar in an animal comprises a mechanical scaffold for testing the skin with a measure of skin tension and a scar making scaffold for creating a hypertrophic scar based on the test tension.
As shown in fig. 2, the skin test mechanical support comprises two skin supports 1, two force measuring connecting blocks 3 and a force measuring screw 4; the two skin brackets 1 are symmetrically arranged; a force measuring connecting block 3 is connected with a corresponding skin bracket 1 through a fixing hoop combination 2; the middle parts of the two force-measuring connecting blocks 3 are respectively provided with a through hole, the through holes of the first force-measuring connecting block are threaded holes, and the through holes of the second force-measuring connecting block are smooth holes; the force measuring screw 4 sequentially passes through the through holes of the two force measuring connecting blocks 3, a threaded structure matched with the threaded hole of the first force measuring is arranged on one side of the force measuring screw 4 provided with the groove, which is provided with the hidden button, and the part of the force measuring screw 4 except the threaded structure is of a smooth structure; two sides of the force measuring screw 4 are respectively provided with a slide bar 6, and the force measuring connecting block 3 can slide along the slide bars 6. The force measuring connecting block 3 is arranged in a clamping groove of the fixed hoop combination 2, and the fixed hoop combination 2 enables the force measuring connecting block 3 and the skin bracket 1 to be fixed into a whole through screws on two sides. The force measuring screw 4 is connected with the chest expander through the hidden buckle side of the groove.
As shown in fig. 3, the scar making stand comprises two skin stands 1, two force application connecting blocks 8 and a rotary screw 7; the two skin brackets 1 are symmetrically arranged, and each skin bracket 1 is provided with a fixing hole for combining with skin; a force-applying connecting block 8 is connected with a corresponding skin bracket 1 through a fixed hoop combination 2; threaded holes are formed in the middle of the two force application connecting blocks 8, and the directions of the two threads are opposite; the rotating screw rod 7 is sequentially connected with the two force application connecting blocks 8 in a threaded manner; two sides of the rotating screw rod 7 are respectively provided with a sliding rod 6, and the force application connecting block 8 can slide along the sliding rod 6.
The skin bracket 1 is of an axisymmetric wing-shaped structure, and a plurality of fixing holes are symmetrically arranged on the skin bracket 1. The skin support 1 has a smooth bottom. The force application connecting block 8 is arranged in a clamping groove of the fixed hoop combination 2, and the fixed hoop combination 2 enables the force application connecting block 8 and the skin bracket 1 to be fixed into a whole through screws on two sides. The middle part of the rotating screw rod 7 is provided with an annular bulge which is arranged between the two force application connecting blocks 8.
The device is made of light materials, and the weight is less than 10g.
With reference to fig. 2, the skin test mechanical stent works as follows:
1) The skin bracket 1 is combined with the skin by sewing 7 round holes on the skin bracket 1, and the tensile force applied by the skin bracket 1 is uniformly conducted to the skin.
2) The force measuring connecting block 3 and the skin bracket 1 are fixed into a whole by rotating screws on two sides of the pressurizing fixing hoop combination 2. The inner part of the force measuring connecting block 3 at one side is fixed with the force measuring screw 4 by a thread structure, can not move on the force measuring screw 4 (the force measuring screw and the screw are used as a whole to jointly bear force to generate displacement), and the other side (the force measuring screw is provided with a groove and hidden buckle side) is not provided with a thread structure in the force measuring connecting block 3, so that the force measuring connecting block 3 can be in a sliding state.
3) The sliding rod 6 is unthreaded, symmetrically penetrates through pore channels on two sides of the force measuring connecting block on two sides of the force measuring screw 4, provides a track for the movement of the force measuring connecting block 3, and prevents the force measuring connecting block 3 from rotating by taking the force measuring screw 4 as an axis to influence the transmission of tensile force.
4) The chest expander is pulled, and because the chest expander is not provided with a thread structure in the chest expander opposite side force measuring connecting block 3, the force measuring screw rod 5 can slide towards the stress direction when the force measuring screw rod is stressed, and the chest expander side force measuring connecting block 3 is provided with a thread structure, so that the skin, the skin support, the force measuring connecting block and the tension threads are displaced in an integrated state when the tension is stressed. Therefore, the tensile force applied when the force-measuring connection block 3 is displaced is the tensile force applied when the skin is pulled.
With reference to fig. 3, the working principle of the animal in vivo scar manufacturing stent is as follows:
1) The skin bracket 1 is combined with the skin by sewing 7 round holes on the skin bracket 1, and the tensile force applied by the skin bracket 1 is uniformly conducted to the skin.
2) The force-applying connecting block 8 and the skin bracket 1 are fixed into a whole by rotating screws on two sides of the pressurizing and fixing hoop combination 2. Both sides application of force connecting block 8 are fixed through the helicitic texture with rotating screw rod 7, but the internal screw thread direction of two application of force connecting blocks 8 is opposite (one side left-handed, one side right-handed), and both can not freely slide on the screw rod.
3) The sliding rod 6 is unthreaded, and symmetrically penetrates through pore canals at two sides of the force application connecting block 8 at two sides of the rotating screw rod 7, so that a track is provided for the movement of the force application connecting block 8, and the force application connecting block 8 is prevented from rotating by taking the force measurement screw rod as an axis, and the transmission of tensile force is influenced.
4) Because the internal thread directions of the force-applying connecting blocks 8 are opposite, and the thread directions on the rotating screw rod 7 are consistent, when the rotating screw rod 7 is driven to rotate clockwise or anticlockwise, the force-applying connecting blocks 8 at the two ends of the screw rod are in a far or near state.
5) Since the skin, the skin support and the force-applying connection block 8 are in a fixed dead state, the skin between the skin support is retracted by the displacement of the force-applying connection block 8, and a tension is generated, and a scar is generated under the influence of the tension.
The using method of the skin test mechanical stent comprises the following steps:
1) Securing the skin support 1 to the skin;
2) The chest expander is connected with the force measuring screw rod, and the force measuring screw rod 4 is pulled to drive the force measuring connecting block 3 to displace, so that tension is generated.
3) The extension distance is measured and the tension value is read.
The using method of the scar manufacturing bracket comprises the following steps:
1) The skin scaffold is secured to the skin.
2) Rotating the rotating screw 7, wherein the two force-applying connecting blocks 8 are displaced to the two sides due to different thread directions of the force-applying connecting blocks 8 at the two sides, and the force-applying amount is set according to the reading measured by the skin test mechanical bracket; stretching the skin.
The foregoing is only a preferred embodiment of the present invention, and is not intended to limit the scope of the invention, but all equivalent changes and modifications within the scope of the present invention should be considered as technical scope of the present invention.
Claims (5)
1. A mechanical device for producing a hypertrophic scar in an animal, comprising: comprising the use of a skin test mechanical scaffold for measuring skin tension and a scar-making scaffold for creating a hypertrophic scar based on the test tension;
the scar manufacturing bracket comprises two skin brackets (1), two force application connecting blocks (8) and a rotary screw (7); the two skin brackets (1) are symmetrically arranged, and each skin bracket (1) is provided with a fixing hole for being connected with skin suture; a force application connecting block (8) is connected with a corresponding skin bracket (1) through a fixed hoop combination (2); threaded holes are formed in the middle of the two force application connecting blocks (8), and the directions of the two threads are opposite; the rotating screw rod (7) is sequentially connected with the two force application connecting blocks (8) in a threaded manner; two sides of the rotating screw rod (7) are respectively provided with a sliding rod (6), and the force application connecting block (8) can slide along the sliding rods (6);
the skin test mechanical support comprises two force measuring connecting blocks (3) and a force measuring screw rod (4); the two skin brackets (1) are symmetrically arranged; a force measuring connecting block (3) is connected with a corresponding skin bracket (1) through a fixing hoop combination (2); the middle parts of the two force-measuring connecting blocks (3) are respectively provided with a through hole, the through holes of the first force-measuring connecting block are threaded holes, and the through holes of the second force-measuring connecting block are smooth holes; the force measuring screw rod (4) sequentially penetrates through the through holes of the two force measuring connecting blocks (3), a threaded structure matched with the threaded hole of the first force measuring is arranged on one side of the side, provided with the groove, of the force measuring screw rod (4), and the part, except the threaded structure, of the force measuring screw rod (4) is of a smooth structure; two sides of the force measuring screw rod (4) are respectively provided with a slide rod (6), and the force measuring connecting block (3) can slide along the slide rods (6);
the force measuring connecting block (3) is arranged in a clamping groove of the fixed hoop combination (2), and the fixed hoop combination (2) enables the force measuring connecting block (3) and the skin bracket (1) to be fixed into a whole through screws on two sides;
the force application connecting block (8) is arranged in a clamping groove of the fixed hoop combination (2), and the fixed hoop combination (2) enables the force application connecting block (8) and the skin bracket (1) to be fixed into a whole through screws on two sides.
2. A mechanical device for producing an animal hypertrophic scar according to claim 1, wherein: the force measuring screw rod (4) is connected with the chest expander through the hidden buckle side of the groove.
3. A mechanical device for producing an animal hypertrophic scar according to claim 1, wherein: the skin support (1) is of an axisymmetric wing-shaped structure, and a plurality of fixing holes are symmetrically formed in the skin support (1).
4. A mechanical device for producing an animal hypertrophic scar according to claim 1, wherein: the bottom of the skin bracket (1) is smooth.
5. A mechanical device for producing an animal hypertrophic scar according to claim 1, wherein: the middle part of the rotating screw rod (7) is provided with an annular bulge, and the annular bulge is arranged between the two force application connecting blocks (8).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710708748.0A CN107374766B (en) | 2017-08-17 | 2017-08-17 | Mechanical device for generating animal hypertrophic scars |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710708748.0A CN107374766B (en) | 2017-08-17 | 2017-08-17 | Mechanical device for generating animal hypertrophic scars |
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| Publication Number | Publication Date |
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| CN107374766A CN107374766A (en) | 2017-11-24 |
| CN107374766B true CN107374766B (en) | 2023-09-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710708748.0A Active CN107374766B (en) | 2017-08-17 | 2017-08-17 | Mechanical device for generating animal hypertrophic scars |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112043405B (en) * | 2020-08-25 | 2021-11-16 | 浙江大学 | Animal skin expansion device based on three-dimensional printing |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006129758A (en) * | 2004-11-05 | 2006-05-25 | Pola Chem Ind Inc | Animal model for hypertrophic scar |
| CN204318817U (en) * | 2014-12-05 | 2015-05-13 | 中国人民解放军第四军医大学 | The outer Distraction Apparatus of skin that a kind of convenience is fixing |
| CN204520724U (en) * | 2014-06-12 | 2015-08-05 | 蒋杰睿 | Measure the device of skin tension |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060037091A1 (en) * | 2004-05-24 | 2006-02-16 | Gurtner Geoffrey C | Method for producing hypertrophic scarring animal model for identification of agents for prevention and treatment of human hypertrophic scarring |
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2017
- 2017-08-17 CN CN201710708748.0A patent/CN107374766B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006129758A (en) * | 2004-11-05 | 2006-05-25 | Pola Chem Ind Inc | Animal model for hypertrophic scar |
| CN204520724U (en) * | 2014-06-12 | 2015-08-05 | 蒋杰睿 | Measure the device of skin tension |
| CN204318817U (en) * | 2014-12-05 | 2015-05-13 | 中国人民解放军第四军医大学 | The outer Distraction Apparatus of skin that a kind of convenience is fixing |
Non-Patent Citations (1)
| Title |
|---|
| 《机械张力诱发小鼠增生性瘢痕的实验研究》;温从吉等;《组织工程与重建外科杂志》;20140630;145-148页，图1 * |
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| CN107374766A (en) | 2017-11-24 |
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