CN107374667A - Body moulds Preparation Method - Google Patents
Body moulds Preparation Method Download PDFInfo
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- CN107374667A CN107374667A CN201710527494.2A CN201710527494A CN107374667A CN 107374667 A CN107374667 A CN 107374667A CN 201710527494 A CN201710527494 A CN 201710527494A CN 107374667 A CN107374667 A CN 107374667A
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- polyvinyl alcohol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/58—Testing, adjusting or calibrating the diagnostic device
- A61B8/587—Calibration phantoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/485—Diagnostic techniques involving measuring strain or elastic properties
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2329/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Derivatives of such polymer
- C08J2329/02—Homopolymers or copolymers of unsaturated alcohols
- C08J2329/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2333/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers
- C08J2333/24—Homopolymers or copolymers of amides or imides
- C08J2333/26—Homopolymers or copolymers of acrylamide or methacrylamide
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Abstract
The invention provides a kind of body to mould Preparation Method, and this method includes：Prepare at least one polyvinyl alcohol water solution containing scattering and/or at least one polyacrylamide hydrogel containing scattering；Polyvinyl alcohol water solution and/or polyacrylamide hydrogel are placed in formation body mould in mould.The polyvinyl alcohol hydrogel and/or polyacrylamide hydrogel formed due to polyvinyl alcohol water solution has intensity height, the characteristics of Flexible change scope is big, and property is stable during using and preserving, so the body mould and/or polyacrylamide hydrogel that are formed by polyvinyl alcohol hydrogel with curing agent by carrying out polymerisation body mould and made of, also have intensity high, there is the characteristics of property stability is strong during preservation and use.
Description
Technical field
The present embodiments relate to medical science technical field of polymer materials, more particularly to a kind of body molding Preparation Method.
Background technology
With the development and the improvement of people's living standards of society, unsound diet has made hepatopathy particularly chronic liver disease
An important factor for as health of people is threatened.
The pathological change of biological tissue is usually associated with the change of its mechanical characteristic such as hardness, and this change is at a variety of groups
There are confirmation and research in knitting.Such as in the inspection of the lesion tissues such as breast lesion, prostate cancer and arteria carotis vulnerable plaque,
It all make use of this tissue characteristics.Equally, hepatic fibrosis progression caused by chronic liver disease to the process of hepatic sclerosis also along with liver
The ascending change of dirty hardness；Liver cancer is usually expressed as the focus harder than surrounding normal hepatic tissue.The change of hardness is corresponding
The change of coefficient of elasticity, in recent years the organization mechanicses characteristic based on elasticity obtained academic and clinical extensive concern.It is academic
The imaging method that tissue elasticity characteristic can be reflected is referred to as elastogram by boundary, and elastography to hepatic tissue by carrying out bullet
Property parameter quantitative detection, contribute to diagnosing liver fibrosis, assessment to every hepatopathy and treatment are significant.
On the one hand ultrasonic elastograph imaging instrument needs to examine the working effect of instrument during research and development and use
Survey, on the other hand, due to reasons such as Aging equipments, it is necessary to be calibrated to instrument.And these are required for ultrasonic elastograph imaging body
Mould is carried out.The species of traditional Ultraphonic elastic imaging body model is a lot, mainly includes gelatin or agar.It is natural high score
Sub- compound.But the bonding of uniform agar body mould is weaker, intensity is also weaker, under the stress of very little just very
Easy fragmentation.The intensity of gelatin body mould is slightly better than agar body mould, but property is unstable during using and preserving, easily with ring
The change of border temperature and change.
The content of the invention
The embodiment of the present invention provides a kind of body molding Preparation Method, this method solve existing body mould and uses gelatin or agar
Prepare, caused by body mould low intensity, the unstable technical problem of property during using and preserving.
The embodiment of the present invention provides a kind of body molding Preparation Method, for ultrasonic elastograph imaging, including：
Prepare at least one polyvinyl alcohol water solution containing scattering and/or at least one polypropylene containing scattering
Acid amides hydrogel；
The polyvinyl alcohol water solution and/or polyacrylamide hydrogel are placed in formation body mould in mould.
The embodiment of the present invention provides a kind of body molding Preparation Method, by preparing at least one polyvinyl alcohol containing scattering
The aqueous solution and/or at least one polyacrylamide hydrogel containing scattering；By the polyvinyl alcohol water solution and/or poly- third
Dilute acid amides hydrogel is placed in formation body mould in mould.The polyvinyl alcohol hydrogel that is formed due to polyvinyl alcohol water solution and/or poly-
Acrylamide hydrogel has the characteristics of intensity is high, and Flexible change scope is big, and property is stable during using and preserving,
So the body mould and/or polyacrylamide hydrogel that are formed by polyvinyl alcohol hydrogel by with curing agent carry out polymerisation and
Manufactured body mould, it may have intensity is high, has the characteristics of property stability is strong during preservation and use.
Brief description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
There is the required accompanying drawing used in technology description to be briefly described, it should be apparent that, drawings in the following description are this hairs
Some bright embodiments, for those of ordinary skill in the art, without having to pay creative labor, can be with
Other accompanying drawings are obtained according to these accompanying drawings.
Fig. 1 is the flow chart that the body that the embodiment of the present invention one provides moulds Preparation Method；
Fig. 2 is the first structure schematic diagram of the body mould formed in the body membrane preparation method that the embodiment of the present invention two provides；
Fig. 3 is the second structural representation of the body mould formed in the body membrane preparation method that the embodiment of the present invention two provides.
Symbol description：
The body moulds of 21- Integral molds 22- the second body moulds 23- the 3rd
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with the embodiment of the present invention
In accompanying drawing, the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is
Part of the embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art
The every other embodiment obtained under the premise of creative work is not made, belongs to the scope of protection of the invention.
It should be appreciated that term "and/or" used herein is only a kind of incidence relation for describing affiliated partner, represent
There may be three kinds of relations, for example, A and/or B, can be represented：Individualism A, while A and B be present, individualism B these three
Situation.In addition, character "/" herein, it is a kind of relation of "or" to typically represent forward-backward correlation object.
Depending on linguistic context, word as used in this " if " can be construed to " ... when " or " when ...
When " or " in response to determining " or " in response to detection ".Similarly, depending on linguistic context, phrase " if it is determined that " or " if detection
(condition or event of statement) " can be construed to " when it is determined that when " or " in response to determine " or " when the detection (condition of statement
Or event) when " or " in response to detecting (condition or event of statement) ".
Fig. 1 is the flow chart that the body that the embodiment of the present invention one provides moulds Preparation Method, as shown in figure 1, the present embodiment provides
Body molding Preparation Method include following steps.
Step 101, at least one polyvinyl alcohol water solution containing scattering and/or at least one are prepared containing scattering
Polyacrylamide hydrogel.
In the present embodiment, different types of polyvinyl alcohol water solution refers to that the concentration of polyvinyl alcohol in aqueous is different.
Different types of polyacrylamide hydrogel refers to that the intensity of polyacrylamide hydrogel and elasticity are different.
Specifically, in the present embodiment, prepare it is at least one containing scattering son polyvinyl alcohol water solution when, will can scatter
Son and polyvinyl alcohol are added to the water, and are prepared according to the concentration of polyvinyl alcohol in aqueous different types of sub containing scattering
Polyvinyl alcohol water solution.
In the present embodiment, containing scattering in polyvinyl alcohol water solution, scattering can be micron-sized graphite, fiber
Element, silica, or other scatterings are sub, are not limited in the present embodiment.Preparing the polyvinyl alcohol water containing scattering
During solution, scattering can be added directly into polyvinyl alcohol water solution.
Wherein, scatter son act as can by manufactured body mould be used for ultrasonic imaging in.
Specifically, in the present embodiment, prepare it is at least one containing scattering son polyacrylamide hydrogel when, will contain not
Polyacrylamide, scattering, crosslinking agent, catalyst and oxidant with molecular weight grade carry out polymerisation in water, are formed
Polyvinyl lactam hydrogel.Wherein, different molecular weight grade can be divided into high molecular weight grades, middle-molecular-weihydroxyethyl grade and low molecule amount
Grade.When preparing different types of polyvinyl lactam hydrogel, according to the quality of the polyacrylamide of different molecular weight grade
It is prepared by proportioning.The polyvinyl lactam quality proportioning of high molecular weight grades is more, the polyvinyl lactam hydrogel prepared
Elasticity is bigger, conversely, the polyvinyl lactam quality proportioning of low molecule amount grade is more, the polyvinyl lactam hydrogel prepared
Elasticity is smaller.Specific quality proportioning, which can illustrate, is：A kind of molecular weight of the unitary system of polyacrylamide is set first,
Such as set standard of the molecular weight as 25,000,000 polyacrylamide as polypropylene acid amides mean molecule quantity, then according to
Height, in, low Three Estate selects the polyacrylamide example in mass ratio of three kinds of hierarchical molecular amounts to mix so that mixed poly- third
Acrylamide mean molecule quantity and 25,000,000 Molecular Weight for Polyacrylamide of setting are roughly equal.PAHG to be improved
Elasticity and intensity then need increase high molecular weight grades polyacrylamide mass ratio, conversely, polyacrylamide to be reduced
The elasticity and intensity of hydrogel need to increase the mass ratio of the polyacrylamide of low molecule amount grade, set different molecular weight grade
The quality of polyacrylamide than principle be to account for half principle nearby, such as be intended to reach 25,000,000 mean molecule quantity, may be selected point
Son amount accounts for 50% for 20,000,000 polyacrylamide unitary system mass ratio, and the polyacrylamide mass ratio of molecular weight 36,000,000 accounts for
40.625%, the polyacrylamide mass ratio of molecular weight 4,000,000 accounts for 9.375%.
Wherein, crosslinking agent can be methylene diacrylamide, and catalyst can be tetramethylethylenediamine, referred to as：TEMED,
Oxidant can be ammonium persulfate.
In the present embodiment, prepare it is at least one containing scattering son polyacrylamide hydrogel when, can also pass through regulation
The concentration of polyacrylamide in aqueous is different types of containing the polyacrylamide hydrogel for scattering son to prepare, to prepare
The body mould of different elasticity, in ultrasonic elastograph imaging.
In the present embodiment, containing scattering in PAHG, scattering can be micron-sized graphite, fine
Dimension element, silica, it can also be other scattering, not limited in the present embodiment.Preparing the polyethylene containing scattering
During acid amides hydrogel, can will scattering son be added directly into the aqueous solution of polyvinyl lactam, and with crosslinking agent, catalyst and oxidation
Agent carries out polymerisation and is made in aqueous.
Step 102, polyvinyl alcohol water solution and/or polyacrylamide hydrogel are placed in formation body mould in mould.
In the present embodiment, polyvinyl alcohol water solution is placed in into formation body mould in mould to be：By polyvinyl alcohol water solution
It is placed in mould, and polyvinyl alcohol water solution is formed polyvinyl alcohol hydrogel, polyvinyl alcohol water using freezing-thawing repeatedly method
Gel is the body mould to be formed.
Or in the present embodiment, polyacrylamide hydrogel is placed in formation body mould in mould, is specially：By polypropylene
Acid amides hydrogel carries out polymerisation, shape with curing agent, initiator, catalyst and crosslinking agent in the corresponding mould for be placed with water
Adult mould.
Or in the present embodiment, polyvinyl alcohol water solution and polyacrylamide hydrogel are placed in formation body mould in mould.
Specifically, polyvinyl alcohol water solution and polyacrylamide hydrogel are placed in mould and form body mould heterogeneous, it is by poly- second
The body mould of enol aqueous solution formation and the body mould formed by polyacrylamide hydrogel are formed.
In the present embodiment, the elasticity of every kind of body mould of formation is different.Use it in ultrasonic elastograph imaging, every kind of body mould
The liver in different times can be simulated.As elastic maximum body mould can simulate healthy liver, the slightly smaller body mould representative hair of elasticity
The liver of raw fibrosis.
The body molding Preparation Method that the present embodiment provides, by preparing at least one polyvinyl alcohol water solution containing scattering
And/or at least one polyacrylamide hydrogel containing scattering；By polyvinyl alcohol water solution and/or polyacrylamide water-setting
Glue is placed in formation body mould in mould.The polyvinyl alcohol hydrogel and/or polyacrylamide water formed due to polyvinyl alcohol water solution
Gel has the characteristics of intensity is high, and Flexible change scope is big, and property is stable during using and preserving, so by poly- second
The body mould and/or polyacrylamide hydrogel that enol hydrogel is formed with curing agent by carrying out polymerisation and manufactured body
Mould, it may have intensity is high, has the characteristics of property stability is strong during preservation and use.
The embodiment of the present invention two additionally provides a kind of body molding Preparation Method, the body film preparation side that the embodiment of the present invention two provides
The step of method moulds Preparation Method with the body that the embodiment of the present invention one provides is identical, and step 101- steps 102 have been carried out entering one
Step refinement, then the body molding Preparation Method that the present embodiment provides comprises the following steps and feature.
Step 201, at least one polyvinyl alcohol water solution containing scattering and/or at least one are prepared containing scattering
Polyacrylamide hydrogel.
Further, in the present embodiment, at least one polyvinyl alcohol water solution containing scattering is prepared, is specifically included：
Scattering and polyvinyl alcohol are added to the water, and the concentration preparation according to polyvinyl alcohol in aqueous is not of the same race
The polyvinyl alcohol water solution containing scattering of class.
Further, in the present embodiment, at least one polyacrylamide hydrogel containing scattering, specific bag are prepared
Include：
Polyacrylamide containing different molecular weight grade, scattering, crosslinking agent, catalyst and oxidant are entered in water
Row polymerisation, and the quality proportioning of the polyacrylamide according to different molecular weight grade, prepare different types of polypropylene acyl
Aqueous amine gel.
Specifically, in the present embodiment, by the polyacrylamide containing different molecular weight grade according to different quality proportionings
Polymerisation, the elasticity of the polyacrylamide hydrogel of formation are carried out in water with scattering, crosslinking agent, catalyst and oxidant
Difference, that is, form different types of polyacrylamide hydrogel.When higher in the polyacrylamide containing different molecular weight grade
The quality proportioning of the polyacrylamide of molecular weight grade is higher, then the elasticity of the polyacrylamide hydrogel formed is bigger.Conversely,
When the quality proportioning of the polyacrylamide of lower molecular weight grade in the polyacrylamide containing different molecular weight grade is higher, then
The polyacrylamide hydrogel of formation it is elastic smaller.
Step 202, polyvinyl alcohol water solution and/or polyacrylamide hydrogel are placed in formation body mould in mould.
Further, polyvinyl alcohol water solution is placed in formation body mould in mould, specifically included：
Polyvinyl alcohol water solution is placed in mould, and it is poly- using freezing-thawing repeatedly method to form polyvinyl alcohol water solution
Polyvinyl alcohol hydrogel, polyvinyl alcohol hydrogel are the body mould to be formed.
Specifically, in the present embodiment, polyvinyl alcohol water solution is prepared into polyvinyl alcohol water using freezing-thawing repeatedly method
Gel.The temperature wherein freezed can be minus 20 degrees, and the temperature of thawing can be 20 degree above freezing.Wherein, can be melted according to freezing
The periodicity of change prepares different types of polyvinyl alcohol hydrogel, freezes the polyvinyl alcohol that the periodicity of thawing is bigger, prepares
Hydrogel elastic is bigger.Also different types of polyvinyl alcohol water can be prepared according to the concentration of polyvinyl alcohol in polyvinyl alcohol water solution
Gel.The concentration of polyvinyl alcohol is bigger, and the elasticity for the polyvinyl alcohol hydrogel prepared is bigger.It is understood that it can integrate
Consider that the periodicity of freezing thawing and the concentration of polyvinyl alcohol prepare different types of polyvinyl alcohol hydrogel.
In the present embodiment, polyvinyl alcohol hydrogel has good greasy property, sufficient damping capaicty, good biofacies
Capacitive, elasticity are big, and intensity is high, the features such as being firmly connected with host bone.
Further, polyacrylamide hydrogel is placed in formation body mould in mould, specifically included：
Polyacrylamide hydrogel is being placed with the corresponding mould of water with curing agent, initiator, catalyst and crosslinking agent
Middle carry out polymerisation, form body mould.
Wherein, curing agent can be a kind of material or mixture promoted or control curing reaction.In the present embodiment, solidification
Agent can be aliphatic amine class or aromatic amines.Such as can be aminoethyl piperazine, m-xylene diamine or the mixture of the two.
Preferably, in the present embodiment, curing agent includes：Aminoethyl piperazine and m-xylene diamine.
Initiator can be ammonium persulfate, and catalyst can be TEMED, and crosslinking agent can be methylene diacrylamide.
In the present embodiment, every kind of polyacrylamide hydrogel containing scattering and curing agent, initiator, catalyst and friendship
Connection agent carries out polymerisation in the corresponding mould for be placed with water and can carried out at normal temperatures, and mixed solution is stirred.
Further, polyvinyl alcohol water solution and/or polyacrylamide hydrogel are placed in into formation body mould in mould also to wrap
Include：
At least another body mould is prepared in the periphery of at least one body mould, to form body mould heterogeneous.
Further, in the present embodiment, at least another body mould is prepared in the periphery of at least one body mould, it is non-equal to be formed
Even body mould, is specifically included：
According to the position relationship of various body moulds in body mould heterogeneous, the body mould that will be close to inner side is put into corresponding mould
In, and the body mould in the close outside comprising the body mould close to inner side is prepared in a mold, to form heterogeneous body mould.
Specifically, in the present embodiment, a variety of body moulds are may include in body mould heterogeneous, the position relationship of a variety of body moulds is
It is diversified.Fig. 2 is the first structure schematic diagram of the body mould formed in the body membrane preparation method that the embodiment of the present invention two provides,
Second structural representation of the body mould formed in the body membrane preparation method that Fig. 3 provides for the embodiment of the present invention two, Fig. 2 and Fig. 3 institutes
The schematic diagram shown represents an example of the heterogeneous body mould of formation respectively, and the structure for the heterogeneous body mould that the present embodiment provides is simultaneously
It is not limited to the situation shown in Fig. 2 and Fig. 3.Body mould heterogeneous shown in Fig. 2 includes three kinds of body moulds.In outermost 3rd body
Mould 23 has coated the body mould 22 of Integral mold 21 and second close to inner side.Also three kinds of body moulds are included in Fig. 3.Outermost 3rd body
Mould 23 has coated the second body mould 22 close to inner side, and the second body mould 22 has coated the Integral mold 21 positioned at most inner side again.
In the present embodiment, the body mould close to inner side is prepared first, then according to the position of the various body moulds of body mould heterogeneous
Relation is put, it is determined that close to position of the body mould in the body mould close to outside of inner side, the body mould that will be close to inner side is put into be formed and leaned on
Predeterminated position in the mould of the body mould in nearly outside, is then poured into mould by the solution for preparing for the body mould for being formed close to outside
In, polymerisation is carried out, is formed close to the body mould in outside, while the body mould close to inner side has been fixed on the body mould close to outside
Predeterminated position.The species for the body mould that the body mould heterogeneous no matter prepared includes is how many, and the principle of preparation is first to prepare to lean on
The body mould of nearly inner side, then the body mould close to outside is prepared, untill whole body mould preparation heterogeneous is completed.
In the present embodiment, prepare body mould heterogeneous and be used in ultrasonic elastograph imaging, the liver that lesion occurs can be simulated, such as
In the elastic highest of the body mould of outermost, with the liver of simulation health.The body mould of the close inner side coated by the body mould of outermost
Elasticity diminishes, and to simulate, there occurs lesion inside the liver of health.
Further, in the present embodiment, the degassing conditions for forming body mould are degasification two hours at a temperature of 110 degree.
Specifically, in the present embodiment, before freezing thawing is repeated in the polyvinyl alcohol water solution containing scattering, carry out
Degassing processing, degasification is carried out to the polyvinyl alcohol water solution containing scattering using vavuum pump, the temperature of degasification is 110 degree, so
Freezing is repeated to the polyvinyl alcohol water solution containing scattering afterwards to melt, can effectively reduce the polyvinyl alcohol hydrogel of formation
Bubble in glue, and then make the Ultraphonic elastic imaging body model to be formed more uniform.
Or in the present embodiment, by every kind of polyacrylamide hydrogel and curing agent, initiator containing scattering, urge
While agent and crosslinking agent carry out polymerisation in the corresponding body mould mould for be placed with water, using vavuum pump to mixed solution
Degasification is carried out, the temperature of degasification is 110 degree, can effectively reduce the bubble in the Ultraphonic elastic imaging body model of formation, make to be formed
Ultraphonic elastic imaging body model it is more uniform.
It is understood that prepare close to outside body mould when degassing conditions also be 110 degree at a temperature of degasification two
Hour, with effective bubble reduced in the heterogeneous body mould formed, make the heterogeneous body mould to be formed more uniform.
The body molding Preparation Method that the present embodiment provides, polyvinyl alcohol water solution and/or polyacrylamide hydrogel are placed in
Body mould is formed in mould to be included：Polyvinyl alcohol water solution is placed in mould, and makes polyvinyl alcohol using freezing-thawing repeatedly method
The aqueous solution formed polyvinyl alcohol hydrogel, polyvinyl alcohol hydrogel is the body mould to be formed, or, by polyacrylamide hydrogel with
Curing agent, initiator, catalyst and crosslinking agent carry out polymerisation in the corresponding mould for be placed with water, form body mould.Or
At least another body mould is prepared in the periphery of at least one body mould, to form body mould heterogeneous.Not androgynous mould can formed
On the basis of, body mould heterogeneous is formed, for that in ultrasonic elastograph imaging, can realize to the liver in different lesions period
Simulation, be more suitable in clinical practice.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, either which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme.
Claims (9)
1. a kind of body moulds Preparation Method, for ultrasonic elastograph imaging, it is characterised in that including：
Prepare at least one polyvinyl alcohol water solution containing scattering and/or at least one polyacrylamide containing scattering
Hydrogel；
The polyvinyl alcohol water solution and/or polyacrylamide hydrogel are placed in formation body mould in mould.
2. according to the method for claim 1, it is characterised in that described that the polyvinyl alcohol water solution is placed in shape in mould
Adult mould, is specifically included：
The polyvinyl alcohol water solution is placed in mould, and makes the polyvinyl alcohol water solution shape using freezing-thawing repeatedly method
Into polyvinyl alcohol hydrogel, the polyvinyl alcohol hydrogel is the body mould to be formed.
3. according to the method for claim 1, it is characterised in that described that the polyacrylamide hydrogel is placed in mould
Body mould is formed, is specifically included：
The polyacrylamide hydrogel is being placed with the corresponding mould of water with curing agent, initiator, catalyst and crosslinking agent
Middle carry out polymerisation, form body mould.
4. according to the method in claim 2 or 3, it is characterised in that described by the polyvinyl alcohol water solution and/or poly- third
Dilute acid amides hydrogel, which is placed in formation body mould in mould, also to be included：
At least another body mould is prepared in the periphery of at least one body mould, to form body mould heterogeneous.
5. according to the method for claim 4, it is characterised in that the periphery preparation at least one body mould is at least another
Kind body mould, to form body mould heterogeneous, is specifically included：
According to the position relationship of various body moulds in the body mould heterogeneous, the body mould that will be close to inner side is put into corresponding mould
In, and the body mould in the close outside of the body mould comprising the close inner side is prepared in the mold, to form body heterogeneous
Mould.
6. according to the method for claim 5, it is characterised in that the temperature that the degassing conditions for forming body mould are 110 degree
Lower degasification two hours.
7. according to the method for claim 6, it is characterised in that it is water-soluble to prepare at least one polyvinyl alcohol containing scattering
Liquid, specifically include：
Scattering and polyvinyl alcohol are added to the water, and prepared not according to the concentration of the polyvinyl alcohol in aqueous
Congener polyvinyl alcohol water solution.
8. according to the method for claim 7, it is characterised in that described to prepare at least one polypropylene acyl containing scattering
Aqueous amine gel, is specifically included：
Polyacrylamide containing different molecular weight grade, scattering, crosslinking agent, catalyst and oxidant are gathered in water
Reaction, and the quality proportioning of the polyacrylamide according to different molecular weight grade are closed, prepares different types of polyacrylamide water
Gel.
9. according to the method for claim 8, it is characterised in that the curing agent includes：Aminoethyl piperazine and isophthalic diformazan
Amine.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710527494.2A CN107374667A (en) | 2017-06-30 | 2017-06-30 | Body moulds Preparation Method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710527494.2A CN107374667A (en) | 2017-06-30 | 2017-06-30 | Body moulds Preparation Method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109085328A (en) * | 2018-09-20 | 2018-12-25 | 刘军 | A kind of division of endocrinology's urine tester |
| CN110292398A (en) * | 2019-07-08 | 2019-10-01 | 清华大学 | Ultrasonic body mould, inclusion enclave mould, lamina mould, with and preparation method thereof |
| CN113749687A (en) * | 2020-06-03 | 2021-12-07 | 株式会社日立制作所 | Test apparatus, test method, and test phantom |
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